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Journal articles on the topic 'Mancini's model'

Author: Grafiati

Published: 7 June 2025

Last updated: 2 August 2025

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1

SALIU, Hasan, Ardita REÇI, and Gazmend ABRASHI. "REVISITING HALLIN AND MANCINI'S MEDIA MODEL: ALBANIA AND KOSOVO." Balkan Social Science Review 21, no. 21 (2023): 235–55. http://dx.doi.org/10.46763/bssr2321235s.

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Suzana, SEMENIUC, and SOPONARU Camelia. "Explanatory Psychological Models of Obsessive Functioning: Systematic Review of Mancini's Cognitive Model and Theoretical Review of Young's Maladaptive Cognitive Schemas Model." BRAIN. Broad Research in Artificial Intelligence and Neuroscience 13, special issue 1 (2024): 309–38. https://doi.org/10.18662/brain/13.1Sup1/321.

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<em>Obsessive-compulsive disorder is one of the most common, debilitating, and expensive illnesses for the medical systems focusing on mental health. Given the heterogeneity specific to obsessive-compulsive symptomatology, experts have proposed several explanatory models over time to point out the mechanisms leading to such pathology. This research study â€“ organised into two parts â€“ analyses existing empirical data regarding two explanatory cognitive models of obsessive functioning, namely Manciniâ€™s cognitive model and Youngâ€

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Vaagan, Robert. "Žiniasklaida, rinka, valstybė ir politika Norvegijoje." Informacijos mokslai 47 (January 1, 2008): 22–36. http://dx.doi.org/10.15388/im.2008.0.3345.

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Straipsnyje remiamasi Hallin ir Mancini (2004) suformuluotu demokratiniu-korporaciniu modeliu, analizuojant žiniasklaidos rinkas kai kuriose Šiaurės ir Vidurio Europos šalyse, taip pat ir Norvegijoje. Norvegijos žiniasklaidos rinkos pokyčių analizė pateikiama penkiose srityse: žiniasklaidos vartojimo, finansavimo, technologijų, nuosavybės ir teisės. Iš dalies galima patvirtinti vieną svarbiausių Hallin ir Mancinio modelio bruožų, t.y. gana intervencinis Norvegijos valdžios vaidmuo žiniasklaidos sektoriuje. Iš kitos pusės, šiuos procesus veikia intensyvus rinkos sąlygų įsigalėjimas. Apskritai,

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Semeniuc, Suzana, and Camelia Soponaru. "Explanatory Psychological Models of Obsessive Functioning: Systematic Review of Mancini’s Cognitive Model and Theoretical Review of Young’s Maladaptive Cognitive Schemas Model." BRAIN. Broad Research in Artificial Intelligence and Neuroscience 13, no. 1Sup1 (2022): 309–38. http://dx.doi.org/10.18662/brain/13.1sup1/321.

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Obsessive-compulsive disorder is one of the most common, debilitating, and expensive illnesses for the medical systems focusing on mental health. Given the heterogeneity specific to obsessive-compulsive symptomatology, experts have proposed several explanatory models over time to point out the mechanisms leading to such pathology. This research study – organised into two parts – analyses existing empirical data regarding two explanatory cognitive models of obsessive functioning, namely Mancini’s cognitive model and Young’s schemas and dysfunctional modes model. The first part comprises three s

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5

Simaku, Xheni. "A Comparative Research Between Italian and Turkish Journalists: Professionalism, Autonomy, Clientelism, and Ethic." SAGE Open 11, no. 2 (2021): 215824402110101. http://dx.doi.org/10.1177/21582440211010173.

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The global society which we live in nowadays makes us rethink about media system, global dynamics, and the operation of the influences that these dynamics have on national media systems. Starting from the book by Hallin and Mancini’s (2004) Comparing Media Systems: Three Models of Media and Politics, and under the Polarized Pluralist Model they proposed, the aim of this work is to compare Turkish and Italian journalists’ professionalization. This research has been conducted under the concept of professionalization that these authors suggested in their work and, more specifically, under the Pol

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Jastramskis, Deimantas. "Lietuvos žiniasklaidos sistemos modelio bruožai." Informacijos mokslai 55 (January 1, 2011): 52–70. http://dx.doi.org/10.15388/im.2011.0.3160.

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Straipsnyje nagrinėjamas Lietuvos žiniasklaidos sistemos funkcionavimas. Remiantis D. Hallino irP. Mancini sudarytais žiniasklaidos sistemų modeliais: poliarizuotuoju pliuralistiniu, demokratiniu korporaciniu ir liberaliuoju, aiškinamasi, kokius šių modelių bruožus yra įgijusi Lietuvos žiniasklaidos sistema. Žiniasklaidos sistemos modelių bruožai nustatomi analizuojant keturias dimensijas: laikraščių industrijos plėtros procesą, politinį paralelizmą žiniasklaidoje, žurnalistinio profesionalizmo esamybę ir valstybės intervencijos į žiniasklaidos sistemą pobūdį.Straipsnyje teigiama, kad formuoja

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K.C., Bhuwan. "Polarized pluralistic model: Characteristics of Nepalese press." Bodhi: An Interdisciplinary Journal 7 (December 31, 2019): 161–86. http://dx.doi.org/10.3126/bodhi.v7i0.27911.

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This paper presents a comparative study of Media System in the context of Nepal on the basis of Hallin and Mancini’s study. The paper shows that the characteristic of Nepalese press match with the polarized pluralistic model, which is prevailed in Southern European states. This study also helps to understand the effect of political parallelism in professionalism of Nepalese press.

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8

Kogen, Lauren. "Savage deregulation in Thailand: expanding Hallin and Mancini’s European model." Media, Culture & Society 32, no. 2 (2010): 335–45. http://dx.doi.org/10.1177/0163443709356148.

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9

Peruško, Zrinjka. "Rediscovering the Mediterranean Characteristics of the Croatian Media System." East European Politics and Societies: and Cultures 27, no. 4 (2013): 709–26. http://dx.doi.org/10.1177/0888325413494770.

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The article presents the analysis of the Croatian post-socialist media system within the comparative framework of Hallin and Mancini’s approach. The media system and the political system are analyzed with the cluster of variables, interpreting the development of the media market, political parallelism, journalistic professionalism, and the role of the state in relation to the existing theoretical framework. The paper demonstrates a perfect fit with the Mediterranean polarized pluralist model of media system, and argues that the Croatian case disproves the proposition that Hallin and Mancini’s

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10

Nechushtai, Efrat. "From Liberal to Polarized Liberal? Contemporary U.S. News in Hallin and Mancini’s Typology of News Systems." International Journal of Press/Politics 23, no. 2 (2018): 183–201. http://dx.doi.org/10.1177/1940161218771902.

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The 2016 presidential election demonstrated the extent to which U.S. news has changed since its “high modernist” moment. Evidence of these shifts—fragmented and poorly monetized news markets, politicization of news content and funding, uneven professionalization, and even increasing openness to state involvement—have been documented in the literature for some years, but often framed as exceptions. This paper revisits Hallin and Mancini’s typology of news systems to suggest that as variants of Polarized Pluralist elements are entrenched in the American news system, it is drifting away from the

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11

Humprecht, Edda, Laia Castro Herrero, Sina Blassnig, Michael Brüggemann, and Sven Engesser. "Media Systems in the Digital Age: An Empirical Comparison of 30 Countries." Journal of Communication 72, no. 2 (2022): 145–64. http://dx.doi.org/10.1093/joc/jqab054.

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Abstract Media systems have changed significantly as a result of the development of information technologies. However, typologies of media systems that incorporate aspects of digitalization are rare. This study fills this gap by identifying, operationalizing, and measuring indicators of media systems in the digital age. We build on previous work, extend it with new indicators that reflect changing conditions (such as online news use), and include media freedom indicators. We include 30 countries in our study and use cluster analysis to identify three clusters of media systems. Two of these clu

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Lozowski, Edward, and Mark R. A. Shegelski. "Comment on “Improved pivot-slide model of the motion of a curling rock”." Canadian Journal of Physics 99, no. 3 (2021): 202–3. http://dx.doi.org/10.1139/cjp-2020-0228.

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We point out three errors in a recent paper that is based on one of our two papers. Together our two papers describe a first-principles “pivot-slide model” of the motion of a curling rock. The most serious error is that the “improved pivot-slide model” (Mancini and de Schoulepnikoff. Can. J. Phys. 97(12), 1301 (2019) doi: 10.1139/cjp-2018-0356 ) is based on only our first paper, whereas the most important work in our model was described in our second paper, which those authors have overlooked. Another error is that the authors claim we use constant friction, whereas we actually use a velocity-

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Dimants, Ainārs. "Skandinavijos investicijų vaidmuo Latvijos žiniasklaidos reintegracijoje į Šiaurės ir Vidurio Europos žiniasklaidos modelį." Informacijos mokslai 47 (January 1, 2008): 37–43. http://dx.doi.org/10.15388/im.2008.0.3344.

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Straipsnio tikslas – trumpai apžvelgti Latvijos žiniasklaidos privatizacijos ir koncentracijos procesus, sąlygotus užsienio investicijų. Straipsnyje nagrinėjama Skandinavijos, daugiausia Švedijos, kapitalo įtaka redakciniam autonomiškumui, naujų redakcinių instrumentų įdiegimui, siekiant žurnalistikos kokybės ir profesionalumo, o taip pat tokioms žurnalistikos struktūroms, kaip: profesinės sąjungos, žurnalistų rengimas ir mokymas bei žiniasklaidos tyrimai.Straipsnyje teigiama, jog pastarųjų metų Latvijos žiniasklaidos raidą atitinka Šiaurės/Vidurio Europos arba demokratinis-korporacinis žinias

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Urbániková, Marína, and Jaromír Volek. "The professional identity of Czech journalists in an international perspective." International Communication Gazette 80, no. 5 (2017): 452–75. http://dx.doi.org/10.1177/1748048517745257.

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This article, placed in the field of comparative journalism studies, explores the extent to which Czech journalists share their professional identity and compares the congruence of their professional identity with selected Western journalistic communities working in the liberal, democratic-corporatist, and polarized pluralism media model defined by Hallin and Mancini. The results show that the professional identity structure of Czech journalists does not, in principle, differ from that of foreign journalists. This implies that they have cut themselves from the Soviet journalistic model. Czech

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15

Graber, Doris A. "Comparing Media Systems: Three Models of Media and Politics ? Daniel C. Hallin and Paolo Mancini." Political Psychology 27, no. 6 (2006): 935–36. http://dx.doi.org/10.1111/j.1467-9221.2006.00547_1.x.

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16

Patterson, Thomas E. "Comparing Media Systems: Three Models of Media and Politics, by Daniel C. Hallin and Paolo Mancini." Political Communication 24, no. 3 (2007): 329–31. http://dx.doi.org/10.1080/10584600701471708.

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17

Hadland, Adrian. "State-media relations in post-apartheid South Africa." Communicare: Journal for Communication Studies in Africa 26, no. 2 (2022): 1–17. http://dx.doi.org/10.36615/jcsa.v26i2.1721.

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In 2004, Daniel Hallin and Paolo Mancini published a landmark work of media theory entitledComparing media systems: three models of media and politics. The theory, like the models itmakes use of, has a high degree of relevance for South African media scholars. Primarily, thetheory investigates the relationship between the state and the media, an interconnection of profoundsignificance in the South African context, yet one that has not been explored sufficiently by scholars.This article, which focuses primarily on South Africa’s print media sector, sets out the parameters,major dimensions and s

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Thibault, Simon, Frédérick Bastien, Tania Gosselin, Colette Brin, and Colin Scott. "Is There a Distinct Quebec Media Subsystem in Canada? Evidence of Ideological and Political Orientations among Canadian News Media Organizations." Canadian Journal of Political Science 53, no. 3 (2020): 638–57. http://dx.doi.org/10.1017/s0008423920000189.

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AbstractIn their much-quoted typology of Western media systems, Hallin and Mancini (2004) associate Canada's media system with what they call the “Liberal model,” given its strong professionalization and limited politicization. They also hypothesize the existence of a more professional and more politicized media subsystem in Quebec. This article tests their hypothesis with data from a 2018 survey of 209 experts across Canada. The findings do not support the hypothesis of a media subsystem in Quebec. However, they show a diversity of ideological and political orientations among news media organ

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Pennini, Flavia, Angelo Plastino, Angel Ricardo Plastino, and Alberto Hernando. "Structural Statistical Quantifiers and Thermal Features of Quantum Systems." Entropy 23, no. 1 (2020): 19. http://dx.doi.org/10.3390/e23010019.

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This paper deals primarily with relatively novel thermal quantifiers called disequilibrium and statistical complexity, whose role is growing in different disciplines of physics and other sciences. These quantifiers are called L. Ruiz, Mancini, and Calvet (LMC) quantifiers, following the initials of the three authors who advanced them. We wish to establish information-theoretical bridges between LMC structural quantifiers and (1) Thermal Heisenberg uncertainties ΔxΔp (at temperature T); (2) A nuclear physics fermion model. Having achieved such purposes, we determine to what an extent our bridge

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Kaiser, Johannes, and Katharina Kleinen-von Königslöw. "Partisan journalism and the issue framing of the Euro crisis: Comparing political parallelism of German and Spanish online news." Journalism 20, no. 2 (2016): 331–48. http://dx.doi.org/10.1177/1464884916683548.

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Empirical studies investigating political parallelism in news coverage mostly look at the frequency and evaluation of party actors, though political parallelism is not only tied to parties but also to broader political ideologies. By contrast, this study examines country differences in political parallelism focusing on the alignment of media’s issue interpretations with political ideologies. Based on a content analysis of 7256 statements in 961 articles about the Euro crisis in German and Spanish online newspapers, issue frames were identified in a data-driven approach before examining how the

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Ceron, Andrea, Sergio Splendore, Thomas Hanitzsch, and Neil Thurman. "Journalists and Editors: Political Proximity as Determinant of Career and Autonomy." International Journal of Press/Politics 24, no. 4 (2019): 487–507. http://dx.doi.org/10.1177/1940161219862489.

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Political economy suggests that media owners try to influence the process of media production by providing career incentives to like-minded journalists and adjusting the level of professional autonomy granted to them. Accordingly, we analyze whether the political distance between editors and journalists (i.e., reporters) affects the careers of journalists in terms of rank and salary, as well as their perceived professional autonomy. We hypothesize that editors reward and allow freedom to journalists whose political viewpoints coincide more precisely with their own. Political proximity to edito

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Loy, Gianni. "Una repubblica fondata sul lavoro." GIORNALE DI DIRITTO DEL LAVORO E DI RELAZIONI INDUSTRIALI, no. 122 (July 2009): 197–238. http://dx.doi.org/10.3280/gdl2009-122001.

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- Italy is a Republic based on labour that recognizes to all the citizens the right to work (artt. 1 and 4, Cost.). Such norms have contributed to create a model of "social" state, whose principles have been developed since the French revolution, as opposite to another model based on private property. Taking into consideration the opinion of the most important scholars who dealt with this topic and deeply marked the debate on this argument (as Mortati, Mancini and Natoli), this Essay focuses on the meaning of artt. 1 and 4 of the Italian Constitution, in line with the original perspective of t

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Rabuffetti, D., G. Ravazzani, S. Barbero, and M. Mancini. "Operational flood-forecasting in the Piemonte region – development and verification of a fully distributed physically-oriented hydrological model." Advances in Geosciences 17 (March 16, 2009): 111–17. http://dx.doi.org/10.5194/adgeo-17-111-2009.

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Abstract. A hydrological model for real time flood forecasting to Civil Protection services requires reliability and rapidity. At present, computational capabilities overcome the rapidity needs even when a fully distributed hydrological model is adopted for a large river catchment as the Upper Po river basin closed at Ponte Becca (nearly 40 000 km2). This approach allows simulating the whole domain and obtaining the responses of large as well as of medium and little sized sub-catchments. The FEST-WB hydrological model (Mancini, 1990; Montaldo et al., 2007; Rabuffetti et al., 2008) is implement

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Rubio Molina, Paulina Gabriela. "Modelo de Sistema Mediático en Argentina en el Contexto Político: Periodo 2007-2015." Rimarina. Revista de Ciencias Sociales y Humanidades 8, no. 2 (2024): 166–76. http://dx.doi.org/10.61236/rima.v8i2.844.

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Este artículo sistematiza uno de los capítulos de la tesis titulada originalmente “Sistemi mediali nei paesi latino-americani: il caso: Messico, Argentina e Brasile”, publicada en 2021. El análisis explora el caso argentino mediante los modelos comparativos de Hallin y Mancini, enfocándose en variables como el origen de los medios de comunicación, el profesionalismo y el rol del Estado. Dentro de este marco, se narra cómo Argentina se compara con modelos europeos, centrándose posteriormente en el grupo mediático “El Clarín”, líder en el mercado de comunicación del país, detallando sus orígenes

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De Ataíde Fonseca, Isadora. "Captured by Elites: The Portuguese Media System in Liberalism (1820–1926)." Central European Journal of Communication 17, no. 2(36) (2024): 223–37. http://dx.doi.org/10.51480/1899-5101.17.2(36).571.

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This article argues that the concept of ‘captured media’ is invaluable to a deeper understanding of the roles performed by media systems throughout European liberalism and early democratization of nineteenth and twentieth centuries. This case-study explores the structures of the media system during Portuguese Liberalism (1820–1926) in the scope of the Portuguese empire. The concept of the ‘Imperial Public Sphere’ is applied to show how imperial and colonial elites captured the media system to exercise and spread its political and ideological power. As a methodological approach to analyze the r

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Beividas, Waldir. "A cólera e suas oscilações tensivas." Estudos Semióticos 20, no. 3 (2024): 131–52. https://doi.org/10.11606/issn.1980-4016.esse.2024.231307.

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In this text, I present two approaches. In the first, I briefly visit three authors who inaugurated what today constitutes the so-called tensive semiotics: A. J. Greimas, B. Pottier and Cl. Zilberberg. In this first movement, I seek to expose the pioneering reflections of these authors on the concept of tensivity, intensity and gradualness, key concepts that will be the methodological basis of the construction of tensive semiotics, in its current models of analysis. I also extend the exposition and visit the reflection of two Brazilian authors, who have explored operational pathways of Pottier

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Smaal, Nicholas, and José Roberto C. Piqueira. "Complexity Measures for Maxwell–Boltzmann Distribution." Complexity 2021 (January 23, 2021): 1–6. http://dx.doi.org/10.1155/2021/9646713.

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This work presents a discussion about the application of the Kolmogorov; López-Ruiz, Mancini, and Calbet (LMC); and Shiner, Davison, and Landsberg (SDL) complexity measures to a common situation in physics described by the Maxwell–Boltzmann distribution. The first idea about complexity measure started in computer science and was proposed by Kolmogorov, calculated similarly to the informational entropy. Kolmogorov measure when applied to natural phenomena, presents higher values associated with disorder and lower to order. However, it is considered that high complexity must be associated to int

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Pastorini, Vanessa. "Amerindian poetics: a reading of anthroposemiotic enunciation." Estudos Semióticos 20, no. 1 (2024): 101–21. http://dx.doi.org/10.11606/issn.1980-4016.esse.2024.216300.

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By proposing the ability to deal with the widest possible range of texts, semiotic theory seeks above all to shed light on the processes of constructing meaning. For this work, we intend to make use of developments in the theory, such as the notion of anthroposemiotic enunciation (Fontanille, 2019) and the tensive arc of the work (Mancini, 2020), with the aim of analyzing Amerindian poetic productions. The shamanic translations of the Marubo peoples, undertaken by anthropologist Pedro Cesarino (2011), constitute the corpus chosen for analysis. The issues addressed are listed in the following o

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Mancini, Flavia, Nadia Bolognini, Emanuela Bricolo, and Giuseppe Vallar. "Cross-modal Processing in the Occipito-temporal Cortex: A TMS Study of the Müller-Lyer Illusion." Journal of Cognitive Neuroscience 23, no. 8 (2011): 1987–97. http://dx.doi.org/10.1162/jocn.2010.21561.

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The Müller-Lyer illusion occurs both in vision and in touch, and transfers cross-modally from vision to haptics [Mancini, F., Bricolo, E., & Vallar, G. Multisensory integration in the Müller-Lyer illusion: From vision to haptics. Quarterly Journal of Experimental Psychology, 63, 818–830, 2010]. Recent evidence suggests that the neural underpinnings of the Müller-Lyer illusion in the visual modality involve the bilateral lateral occipital complex (LOC) and right superior parietal cortex (SPC). Conversely, the neural correlates of the haptic and cross-modal illusions have never been investig

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Jones, Timothy M. "Book Review: Hallin, D. C., & Mancini, P. (2004). Comparing Media Systems: Three Models of Media and Politics. Cambridge, UK: Cambridge University Press." Comparative Political Studies 41, no. 1 (2007): 128–31. http://dx.doi.org/10.1177/0010414007308531.

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dos Santos, Antonio Nacílio Sousa, José Neto de Oliveira Felippe, Gabriel dos Santos Kehler, et al. "A EDUCAÇÃO (IM)POSSÍVEL NA ORDEM DO CAPITAL – BNCC, EDUCAÇÃO INTEGRAL E OS DESAFIOS PARA UMA PRÁTICA PEDAGÓGICA TRANSFORMADORA." ARACÊ 7, no. 2 (2025): 9934–63. https://doi.org/10.56238/arev7n2-307.

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The National Common Curricular Base (BNCC), while proposing a comprehensive education of the student, reinforces a technicist perspective aligned with market demands, limiting teacher autonomy and the construction of a critical practice. In the context of neoliberalism, Integral Education is emptied of its transformative potential and converted into a mechanism for adapting to the world of work, prioritizing instrumental competencies and skills to the detriment of humanistic training. That said, we ask: In what way do the BNCC and the conception of Integral Education, within the neoliberal log

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Manasyan, S. G., S. Yu Ermolov, A. G. Apresyan, and T. V. Ermolova. "Integral Assessment of Intrheateral Blood Flow — a New Direction in Non-Invasive Diagnostics of Chronic Liver Diseases." Russian Archives of Internal Medicine 13, no. 1 (2023): 65–74. http://dx.doi.org/10.20514/2226-6704-2023-13-1-65-74.

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Purpose of the study. To assess the sensitivity, specificity and diagnostic accuracy of the method for non-invasive differential diagnosis of liver diseases by polyhepatography.Materials and methods. A random sampling method examined 45 primary patients. Polygepatography was performed on all patients to detect disorders of intrahepatic microcirculation during primary contacting. Based on the detected changes in intrahepatic hemodynamics and based on the morphofunctional hemodynamic model, a conclusion was made about the violation of intrahepatic blood flow and an assumption was made about the

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Poon, Sanson, Avellina Leong, Thomas Fogerty, et al. "Automatic Detection and Identification of Calcareous Nannofossils in Chalk Using Deep Learning: A Proof-of-Concept Study for Biostratigraphy and Climate Research." Biodiversity Information Science and Standards 8 (October 7, 2024): e138673. https://doi.org/10.3897/biss.8.138673.

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Calcareous nannofossils serve as crucial indicators for establishing the biostratigraphic age of chalk macrofossil specimens in natural science collections. Better age control of specimens collected several hundred years ago enables us to uncover the dark data hidden within these collections and incorporate these data into current research projects, examining ecosystem response to past climate change. However, the manual identification of these microscopic organisms is laborious and subjective, and so we are harnessing deep learning techniques for automatic nannofossil detection and identifica

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Kamali, Samaneh, Stefano Cairo, Fu-Ju Chou, et al. "Abstract 4258: An innovative PDX and patient-derived 3D platform for improved translatability of new medical entities." Cancer Research 84, no. 6_Supplement (2024): 4258. http://dx.doi.org/10.1158/1538-7445.am2024-4258.

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Abstract The preclinical platform landscape in oncology has radically changed in the last 15 years, mainly due to an increased ability to generate patient-derived models. Multiple 3D tumor cell cultures methods, either from established cell lines or from primary cultures, have been developed to assess the activity of therapeutic agents in vitro. These methods are strongly influenced by the experimental conditions, such as cell culture conditions, the presence of 3D supports like Matrigel, and the experimental design of the assay, such as the choice of the dose and the duration of the assay. Th

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Brugat, T., B. Rugeri, G. Hommet, et al. "OP0236 RELEVANCE OF BIASED PAR2 INHIBITORS IN REDUCING INFLAMMATION AND CARTILAGE DEGRADATION IN IN VITRO AND IN VIVO MODELS OF RHEUMATOID ARTHRITIS." Annals of the Rheumatic Diseases 79, Suppl 1 (2020): 149.2–150. http://dx.doi.org/10.1136/annrheumdis-2020-eular.5353.

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Background:Protease-activated receptor-2 (PAR2) is a member of a family of G-protein-coupled receptors involved in multiple physiological mechanisms. Compelling evidences have unravelled the key roles of PAR2 in the pathology of both rheumatoid arthritis (RA) and osteoarthritis (OA)1. Indeed, in vitro, in vivo and ex vivo experiments showed that this receptor promotes inflammation, cartilage erosion (and subsequent bone degradation), and pain. However, the signalling pathways involved in these functions are not well understood2. This is of importance as some pathways can promote the pathogenes

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Sambandam, Vaishnavi, Sharvari Inamdar, Haoting Hsu, et al. "Abstract 207: Ex vivo modeling of multiple myeloma: A novel drug sensitivity screening platform." Cancer Research 83, no. 7_Supplement (2023): 207. http://dx.doi.org/10.1158/1538-7445.am2023-207.

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Abstract Multiple Myeloma (MM) is a heterogeneous malignancy characterized by abnormal clonal plasma cell infiltration in the bone marrow. It is the second most common hematologic malignancy, after non-Hodgkin’s Lymphoma. This deadly disease globally affects 1 to 5 people in every 100,000 people each year. After initial diagnosis, the 5-year survival rate is 44% because there is no curative therapy, and most patients will eventually experience relapse, and some become refractory. Large inter-patient and intra-patient genetic heterogeneity limit the identification of universal drivers of MM. Ho

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Zeddies, Sabrina, Sjoert B. G. Jansen, Sylvia Nuernberg, et al. "MEIS1 Induces a Megakaryocyte-Erythroid Fate by Upregulation of FOG1 and GATA1 Expression." Blood 120, no. 21 (2012): 2330. http://dx.doi.org/10.1182/blood.v120.21.2330.2330.

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Abstract Abstract 2330 The homeobox transcription factor MEIS1 is expressed in hematopoietic stem- and progenitor cells (HSCs & HPCs, respectively) such as human CD34+ cells, whereas its expression in lineage-committed blood cells is restricted to megakaryocytes (MKs). We observed that MEIS1 not only drives megakaryopoiesis but is also indispensable for the differentiation of HPCs towards the erythroid lineage. In cord blood CD34+ cells lentiviral-driven MEIS1 overexpression resulted in a 3-fold increase in BFU-E at the expense of CFU-GM colonies and a 2-fold increase in MK colonies was re

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Malyuk, M. О., O. V. Yehorov, I. O. Kharkevych, T. L. Savchuk, and V. V. Klymchuk. "The state of the humoral and cellular links of immunity of recipient rabbits following allogeneic transfusion of erythrocyte mass." Regulatory Mechanisms in Biosystems 14, no. 3 (2023): 487–91. http://dx.doi.org/10.15421/10.15421/022369.

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The study of activation of the humoral link of immunity of recipient rabbits following allogeneic transfusion of erythrocyte mass is important for a fundamental understanding of the formation of immunity in model species of animals. We measured the contents of B-lymphocytes, immunoglobulins of M, G, A classes, circulating immune complexes in blood of the recipient rabbits and antibody-dependent cytotoxic activity of lymphocytes. Number of B-lymphocytes in the blood of the rabbits was determined according to Bianco. Immunoglobulin content in blood serum of the rabbits was measured based on the

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Light, Taylor, Samaneh Kamali, Mara Gilardi, Abhay Andar, Karin Abarca-Heidemann, and Maria Mancini. "Abstract 4257: A novel 3D co-culture platform for patient-specific immune-oncology treatment." Cancer Research 84, no. 6_Supplement (2024): 4257. http://dx.doi.org/10.1158/1538-7445.am2024-4257.

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Abstract Lung cancer is the leading cause of global cancer-related mortality resulting in ~1.8 million deaths. annually. Over the past decade, the contribution of tumor microenvironment (TME) in lung cancer progression has been highly appreciated and provided significant improvements of survival outcomes for patients. That includes the complexity of the tumor immune microenvironment (TIME) playing a critical role in cancer progression. However, drug resistance usually arises and there is an urgent need for novel immune cell-based therapies. 3D tumor cell structures that recapitulate the archit

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Veeraraghavan, Jamunarani, Sreyashree Bose, Ragini Mistry, et al. "Abstract PD8-06: Acquired resistance to tucatinib is associated with EGFR amplification in HER2+ breast cancer (BC) models and can be overcome by a more complete blockade of HER receptor layer." Cancer Research 82, no. 4_Supplement (2022): PD8–06—PD8–06. http://dx.doi.org/10.1158/1538-7445.sabcs21-pd8-06.

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Abstract Background: With recent approval of the irreversible pan-HER tyrosine kinase inhibitor (TKI) neratinib (N) and the HER2-specific TKI tucatinib (T) in the advanced setting and their edging towards the early setting in HER2+ BC, resistance will likely emerge as a challenge, as illustrated by the HER2CLIMB study, where only one patient with brain metastasis remained progression free after 2 years on T. We set out to define the mechanisms of resistance to T and treatment strategies to overcome it. Materials and Methods: Our previously characterized HER2+ BT474 models with acquired resista

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Bose, Sreyashree, Ragini Mistry, Chia Chia Liu, et al. "Abstract P4-01-01: Resistance to next generation tyrosine kinase inhibitors (TKIs) in HER2-positive breast cancer (BC): Role of HER and PIK3CA mutations and development of new treatment strategies and study models." Cancer Research 82, no. 4_Supplement (2022): P4–01–01—P4–01–01. http://dx.doi.org/10.1158/1538-7445.sabcs21-p4-01-01.

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Abstract Background: We recently reported that acquired resistance to the dual HER1/2 TKI lapatinib (Lap) was mediated by HER2 L755S, while resistance to the pan-HER TKI neratinib (Nrb) was associated with co-acquisition of an additional pathogenic PIK3CA mutation. Though the role of HER2 mutations is gaining attention in HER2-positive (+) BC, less is known about their role and clinical implications in next generation TKI resistance, particularly when co-occurring with PIK3CA mutations in HER2+ BC. Investigating optimal treatment combinations and the development of new clinically relevant 3D m

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Veeraraghavan, Jamunarani, Fu-Tien Liao, Tia Gordon, et al. "Abstract LB517A: The role of EGFR in resistance to tucatinib and its therapeutic implications." Cancer Research 82, no. 12_Supplement (2022): LB517A. http://dx.doi.org/10.1158/1538-7445.am2022-lb517a.

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Abstract Tucatinib (Tuc) was recently approved for metastatic disease and is moving towards the early setting in HER2+ breast cancer (BC). Given the increasing clinical use of Tuc, resistance will likely soon emerge as a challenge. Here, we explore the yet unknown mechanisms of resistance to Tuc and identify treatment strategies to overcome it. Our recently developed models of BT474 (AZ and ATCC) with acquired resistance to Tuc (TucR) and their sensitive parental (P) were used. DNA-seq, RNA-seq, and RPPA/western blot were performed. Knockdown studies were performed using EGFR siRNA. Drug effic

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Geva, Ravit, Daniel Juneau, Shadi Abdar Esfahani, et al. "Abstract CT112: Phase I open-label, multi-center study to evaluate the safety, tolerability, dosimetry, and preliminary activity of FXX489 ([177Lu]Lu-NNS309) in patients with pancreatic, lung, breast and colorectal cancers." Cancer Research 85, no. 8_Supplement_2 (2025): CT112. https://doi.org/10.1158/1538-7445.am2025-ct112.

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Abstract Background: Fibroblast activation protein (FAP) is a type II integral membrane glycoprotein, highly expressed on the cell surface of cancer-associated fibroblasts (CAFs) present in the tumor microenvironment of most epithelial cancers and showing limited expression in normal tissues. Given this expression profile, FAP appears to be a promising target for radioligand therapy that has pan-cancer potential. [177Lu]Lu-NNS309 is a FAP-targeted radiopharmaceutical that shows improved tumor retention and demonstrates promising anti-tumor activity in translationally relevant preclinical model

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Schifano, Emily, Giorgia Conta, Adele Preziosi, et al. "2-hydroxyisobutyric acid (2-HIBA) modulates ageing and fat deposition in Caenorhabditis elegans." Frontiers in Molecular Biosciences 9 (November 23, 2022): 986022. https://doi.org/10.3389/fmolb.2022.986022.

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High levels of 2-hydroxyisobutyric acid (2-HIBA) were found in urines of patients with obesity and hepatic steatosis, suggesting a potential involvement of this metabolite in clinical conditions. The gut microbial origin of 2-HIBA was hypothesized, however its actual origin and role in biological processes are still not clear. We investigated how treatment with 2-HIBA affected the physiology of the model organism <em>Caenorhabditis elegans</em>, in both standard and high-glucose diet (HGD) growth conditions, by targeted transcriptomic and metabolomic analyses, Coherent Anti-Stokes Raman Scatte

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Saliu, Hasan, Ardita Reçi, and Gazmend Abrashi. "Revisiting Hallin and Mancini's Media Model: Albania and Kosovo." SSRN Electronic Journal, 2023. http://dx.doi.org/10.2139/ssrn.4497644.

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Neff, Timothy, and Victor Pickard. "Funding Democracy: Public Media and Democratic Health in 33 Countries." International Journal of Press/Politics, December 13, 2021, 194016122110602. http://dx.doi.org/10.1177/19401612211060255.

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This study examines whether and how public media systems contribute to the health of democracies in 33 countries in Europe, Africa, Asia, North America, the Middle East, Latin America, and South America. We gather national economic data and public media funding levels, audience shares, and regulatory data, primarily for 2018 and 2019 but in some cases earlier, due to lack of available data. We then assess correlations with strength of democracy indices and extend Hallin and Mancini's typology of North American and European media systems through hierarchical cluster analysis of these 33 countri

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Akser, Murat, and Banu Baybars. "Media Systems and Media Capture in Turkey: A Hybrid Approach." Media and Communication 12 (April 11, 2024). http://dx.doi.org/10.17645/mac.7733.

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<p>Hallin and Mancini's media systems model did not include Turkish media in their landmark study that introduced the concept initially. Later attempts that tested Turkey's media system found it to be somewhat closer to the <em>Mediterranean model</em> and <em>pluralist polarised</em> model. Yet the media landscape shifted so quickly in Turkey, that these categorizations rapidly lost their grip in the last two decades. We propose that the Turkish media system shifted to become a hybrid media system based heavily on media capture. Three of Hallin and Mancini media

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Curini, Luigi, Diego Garusi, and Sergio Splendore. "“It's the ideology, stupid!”: Trust in the press, ideological proximity between citizens and journalists and political parallelism. A comparative approach in 17 countries." International Communication Gazette, April 9, 2023, 174804852311655. http://dx.doi.org/10.1177/17480485231165596.

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Matching national surveys with the dataset offered by the Worlds of Journalism Study network (2012–2016), this article presents an analysis of trust in the press covering 16 European countries and the United States. Drawing from the spatial proximity model of voter utility, this article focuses on the ideological proximity between journalists’ and citizens’ left-right positions as a determinant of trust in the press. We expect a positive relationship between these two variables. However, we also hypothesize that the strength of such relationship is mediated by the type of media model (accordin

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Lešek, Anja, and Dušan Žagar. "Use of the particle tracking method for modelling the transport and deceasing of Escherichia coli in the sea." Acta hydrotechnica, December 1, 2018, 119–42. http://dx.doi.org/10.15292/acta.hydro.2018.08.

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We discuss modeling of the transport and decease of bacteria Escherichia coli in marine environments. We calculated the spatially variable decease coefficient of E. coli from the extrapolated measurement data on environmental parameters in accordance with Mancini's equation for bacteria stemming from the Rižana River and entering into the computational domain – the eastern part of the Koper Bay. Using pre-computed circulation data and the modified particle-tracking model Nafta3D we performed two-day simulations of an instantaneous and a continuous release from a single source. We analyzed loca

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Echeverria, Martin, Rubén Arnoldo González, and Vıctor Hugo Reyna. "Bringing History back into Media Systems Theory. Multiple Modernities and Institutional Legacies in Latin America." International Journal of Press/Politics, November 25, 2022, 194016122211413. http://dx.doi.org/10.1177/19401612221141315.

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Since Hallin and Mancini's (2004) seminal work, many scholars from around the world have proposed different models of media systems for countries and regions outside the Western world. Particular challenges have arisen when conceptualizing the systems in Latin America, where shifting liberal and polarized pluralist models have been proposed, and where media traits like clientelism and collusion remain in spite of political, economic and social changes. We contend that one obstacle to the characterization of the resilience of certain structures and practices in this region is the lack of a hist

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