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Journal articles on the topic 'Mannich's bases'

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Published: 5 June 2025

Last updated: 1 August 2025

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1

Layth W. Abdullah, Hanaa K.Saleh, and Mustafa R. Aeyyd. "Synthesis and characterization of novel Mannich's bases incorporated with Ibuprofen an Biginelli Derivatives." Tikrit Journal of Pure Science 22, no. 3 (2023): 79–88. http://dx.doi.org/10.25130/tjps.v22i3.716.

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In this work, a series of novel Mannich's bases incorporated with Ibuprofen core and Biginelli derivatives have been reported. The synthesis process was dependent on linking Ibuprofen hydrazone with Isatin to Biginelli derivatives via methylene group of formaldehyde. The new compounds have been characterized using FT-IR spectroscopy, 1H-NMR spectroscopy and the physical properties.

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2

A.Yu., Teslenko, Shishlov O.F., Glukhikh V.V., and Yeltsov O.S. "Advanced binders for plywood based on epoxy systems with Mannich's cardanol-containing bases." Systems. Methods. Technologies, no. 1(45) (2020): 85–90. http://dx.doi.org/10.18324/2077-5415-2020-1-85-90.

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3

Meenakshi, Agrawal. "Synthesis and antimicrobial activity of some novel Mannich's bases of 3- sulfamerazinyl substituted spiro (isatoic anhydrido-4-thiazolidinone) derivatives." Journal of Indian Chemical Society Vol. 92, Jan 2015 (2015): 135–40. https://doi.org/10.5281/zenodo.5606549.

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Department of Chemistry, Teerthanker Mahaveer University, Moradabad-244 102, Uttar Pradesh, India <em>E-mail</em> : meenakshi.agrawal2011@gmail.com <em>Manuscript received online 05 September 2013, accepted 07 August 2014</em> Synthesis of novel 3´-[4´-<em>N</em>-{4-methyl-2-pyrimidinyl}-benzene suphonamido]-spiro-(3H-isatoic anhydride-3,2´- thiazolidin)-1<em>H</em>-2,4´(<em>5H</em>)dione (5) and their Mannich’s bases 6(a-g) has been described. Treatment of isatoic anhydride (1) with sulphamerazine (2) yielded 4-[1,2-dihydro-2-oxo-3<em>H</em>-isatoic anhydride-3-y

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4

Hajiyeva, G. E., E. H. Mammadbayli, S. I. Ibrahimli, and I. A. Jafarov. "NORBORNENE-CONTAINING MANNICH BASES ON THE BASIS OF ALIPHATIC AMINES." Azerbaijan Chemical Journal, no. 3 (2018): 50–56. http://dx.doi.org/10.32737/0005-2531-2018-3-50-56.

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5

Roth, Hermann J. "„Mannichs molekularsymmetrische Basen” (Zum 50. Todestag von Carl Mannich)." Pharmazie in Unserer Zeit 26, no. 6 (1997): 299–308. http://dx.doi.org/10.1002/pauz.19970260610.

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6

V., J. Patro, S. Panda C., M. Sahoo B., K. Mishra N., and R. Panda J. "Synthesis and screening for antibacterial, analgesic and anti-inflammatory activity of Mannich bases derived from 1H-indole-2,3-dione." Journal of Indian Chemical Society Vol. 89, Jul 2012 (2012): 913–18. https://doi.org/10.5281/zenodo.5766824.

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Department of Pharmaceutical Chemistry, Roland Institute of Pharmaceutical Sciences, Berhampur-760 010, Orissa, India <em>E-mail</em> : jrpanda77@gmail.com Department of Pharmaceutical Chemistry, Indira Gandhi Institute of Pharmaceutical Sciences, Bhubaneswar, Orissa, India <em>Manuscript received 04 February 2011, revised 16 June 2011, accepted 08 November 2011</em> The reaction of isatin (1<em>H</em>-indole-2,3-dione) with substituted anilines in presence of acetic acid produces Schiff bases. Reaction of the Schiff bases with different secondary amines in presence of formaldehyde yields Mann

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7

Mardia, Telep El-Sayed. "Synthesis and Antimicrobial Evaluation of Some Nitro-Mannich Bases Derived from β-Nitrostyrene". Open Journal of Chemistry 1, № 1 (2015): 013–16. https://doi.org/10.17352/ojc.000003.

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The present work focused on exploring the reactivity of β-nitrostyrene towards Mannich reaction with different approaches. The synthesized nitro-Mannich bases were tested as antimicrobial agents that showed high activity against both gram positive and gram negative bacteria.

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8

Hajiyeva, G. E. "SYNTHESIS OF MANNICH BASES BASED ON NORBORNENYLMETHANOL, CYCLIC AMINES AND BENZALDEHYDE AND THEIR ANTIMICROBIAL ACTIVITY." Azerbaijan Chemical Journal, no. 3 (October 10, 2019): 68–74. http://dx.doi.org/10.32737/0005-2531-2019-3-68-74.

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9

Abdel, Karim M., I. Hala, and M. Khalid. "Synthesis and Antimicrobial Activity of Phenol-derived Mannich Bases." Pharmaceutical and Chemical Journal 4, no. 6 (2017): 107–13. https://doi.org/10.5281/zenodo.13888833.

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Using p-acetamidophenol as an active hydrogen component, two Mannich bases: N,N-[(<strong>5-</strong>acatamido-2-hydroxy)benzyl]ethylamine(I)<strong> </strong>and N-[(5-acatamido-2-hydroxy)benzyl]ethylamine(II) were synthesized via a general synthesis protocol. .The structures of the target molecules were elucidated by a combination of spectral techniques (UV, IR, <sup>1</sup>H NMR and MS). The Mannich bases were evaluated for their antimicrobial activity against seven standard human pathogens. Compounds I and II showed excellent activity against <em>Escherichia coli </em>at 10 and 20mg/ml. Fu

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10

Panda, Jnyanaranjan. "Synthesis and Biological Evaluation of Some Isatin-based Mannich Bases." International Journal of Pharmaceutical Sciences and Nanotechnology 5, no. 4 (2013): 1841–46. http://dx.doi.org/10.37285/ijpsn.2012.5.4.3.

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 In this study, a series of isatin-based Mannich bases were prepared and their biological activity was evaluated. Schiff bases of isatin were synthesized by condensation of the keto group of isatin with different aromatic primary amines. The N-Mannich bases of the above Schiff bases were synthesized by reaction of the acidic imino group of isatin with formaldehyde and secondary amine. The chemical structures of the title compounds have been confirmed and elucidated by means of their physical and spectral data respectively. The compounds were tested for their possible antibacterial, analg

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11

Amin, Henna, Sharad Wakode, Rajiv Kumar Tonk, and Avneet Kaur. "Synthesis, Characterization and Antioxidant Activity of Morpholine Mannich Base Derivatives." International Journal of Current Pharmaceutical Review and Research 8, no. 5 (2017): 354–60. https://doi.org/10.5281/zenodo.12674908.

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A series of morpholine mannich base derivatives were synthesized by a single step reaction of morpholine with substitutedbenzaldehydes and N-phenylacetamide. Progress of reaction was monitored by TLC using ethylacetate and n-hexane asmobile phase. The compounds were characterized by ATR and 1HNMR spectral analysis. Antioxidant assay of thesynthesized compounds was done by DPPH and ABTS assay method using Ascorbic acid as standard. The synthesizedmorpholine mannich base derivatives demonstrated significant radical scavenging property.

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12

SETHI, RITCHU, SANDEEP ARORA, NEELAM JAIN, and SANDEEP JAIN. "Mannich Bases of 2-Substituted Benzimidazoles - A Review." JOURNAL OF PHARMACEUTICAL TECHNOLOGY, RESEARCH AND MANAGEMENT 3, no. 2 (2015): 97–111. http://dx.doi.org/10.15415/jptrm.2015.32008.

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13

Isgor, Kucukgul, Karaman, et al. "IN VITRO AND IN SILICO CYTOTOXICITY EVALUATION OF SOME ISATIN MANNICH BASES ON HUMAN MELANOMA CELLS." Apoptosis, cytotoxicity, isatin mannich bases, melanoma, molecular docking 16, no. 1 (2022): 102–14. https://doi.org/10.5281/zenodo.5826186.

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Mannich bases tend to suppress cell proliferation in damaged tissues because of particular metal chelation properties. Amine components of isatin mannich bases - piperidine (P1), morpholine (P2) and N-methyl piperazine (P3) – were evaluated for their cytotoxicity potentials on melanoma cells. P1, P2 and P3 products were purified using crystallization and characterized by NMR. Human melanoma cells (G361) were produced in DMEM medium including 10% FBS, 1% penicillin/streptomycin at 37°C and 5% CO<sub>2</sub> conditions. Compounds were applied to medium containers separated to 24 pieces

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14

JEHANE, A. A. MIKY, M. SALEH NADIA, and A.M. M. SHMEISS NADIA. "Synthesis and Reactions of Mannich Bases of 3-Hydroxycoumarin." Journal of Indian Chemical Society Vol. 74, Oct 1997 (1997): 814–15. https://doi.org/10.5281/zenodo.5899970.

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Chemistry Department, Faculty of Science (Girls), Al-Azhar University, Nasr City, Cairo, Egypt <em>Manuscript received 23 April 1996, accepted 1 November 1996</em> Synthesis and Reactions of Mannich Bases of 3-Hydroxycoumarin.

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15

Journal, Baghdad Science. "Synthesis And Characterization Of Some New Acetylenic Mannich Bases Based On Biphenyl – 4,4 - Dithiol." Baghdad Science Journal 10, no. 3 (2013): 712–23. http://dx.doi.org/10.21123/bsj.10.3.712-723.

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One of the most important , compound which have active hydrogen is the compound possessing (thiol group) Biphenyl-4,4-dithiol is agood example utilized in a wide field for preparation mannich bases , avariety of new acetylenic mannich bases have been Synthesized and all proposed structure were Supported by FTIR , 1H – NMR, 13C-NMR , Elemental analysis and microbial study .

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16

Al-Abdaliy, Basim I., and Eman M. Mohammed. "Synthesis And Characterization Of Some New Acetylenic Mannich Bases Based On Biphenyl – 4,4 - Dithiol." Baghdad Science Journal 10, no. 3 (2013): 712–23. http://dx.doi.org/10.21123/bsj.2013.10.3.712-723.

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One of the most important , compound which have active hydrogen is the compound possessing (thiol group) Biphenyl-4,4-dithiol is agood example utilized in a wide field for preparation mannich bases , avariety of new acetylenic mannich bases have been Synthesized and all proposed structure were Supported by FTIR , 1H – NMR, 13C-NMR , Elemental analysis and microbial study .

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17

BALAKRISHNA, KALLURAYA, and N. SHETTY SURESH. "Synthesis and Biological Properties of Mannich Bases of some 5-Substituted-1,3,4- oxadiazol-2-thiones." Journal of Indian Chemical Society Vol. 68, Jul 1991 (1991): 424–25. https://doi.org/10.5281/zenodo.6159624.

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Department of Studies in Chemistry, Man galore University. Mangalagangothri-574 199 <em>Manuscript received 13 December 1990 revised 11 July 1991, accepted 17 July 1991</em> Synthesis and Biological Properties of Mannich Bases of some 5-Substituted-1,3,4- oxadiazol-2-thiones.

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18

Mutahir, Sadaf, Muhammad Asim Khan, Maryam Mushtaq, et al. "Investigations of Electronic, Structural, and In Silico Anticancer Potential of Persuasive Phytoestrogenic Isoflavene-Based Mannich Bases." Molecules 28, no. 15 (2023): 5911. http://dx.doi.org/10.3390/molecules28155911.

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Isoflavenes have received the greatest research attention among the many groups of phytoestrogens. In this study, various isoflavene-based Mannich bases were selected for their theoretical studies. The purpose of this research was to discover the binding potential of all the designated Mannich bases acting as inhibitors against cancerous proteins EGFR, cMet, hTrkA, and HER2 (PDB codes: 5GTY, 3RHK, 6PL2, and 7JXH, respectively). For their virtual screening, DFT calculations and molecular docking studies were undertaken using in silico software. Docking studies predicted that ligands 5 and 15 ex

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19

Bala, Suman, Neha Sharma, Anu Kajal, Sunil Kamboj, and Vipin Saini. "Mannich Bases: An Important Pharmacophore in Present Scenario." International Journal of Medicinal Chemistry 2014 (November 12, 2014): 1–15. http://dx.doi.org/10.1155/2014/191072.

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Mannich bases are the end products of Mannich reaction and are known as beta-amino ketone carrying compounds. Mannich reaction is a carbon-carbon bond forming nucleophilic addition reaction and is a key step in synthesis of a wide variety of natural products, pharmaceuticals, and so forth. Mannich reaction is important for the construction of nitrogen containing compounds. There is a number of aminoalkyl chain bearing Mannich bases like fluoxetine, atropine, ethacrynic acid, trihexyphenidyl, and so forth with high curative value. The literature studies enlighten the fact that Mannich bases are

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20

Jafarov, I. A., E. H. Mammadbayli, K. A. Kochetkov, A. D. Astanova, and G. M. Talybov. "SYNTHESIS OF NOVEL MANNICH BASES ON THE BASE OF 1-PHENOXY-3-PROPYLTHIOPROPANE-2-OL AND SECONDARY AMINES." Azerbaijan Chemical Journal, no. 2 (June 20, 2019): 29–34. http://dx.doi.org/10.32737/0005-2531-2019-2-29-34.

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21

Ritu, Vyas, K. Rawal Manish, Ameta Rakshit, K. Chittora Anil, and B. Punjabi Pinki. "Microwave assisted aminomethylation of some heterocyclic compounds bearing imidazolone moiety and their biological assay." Journal of Indian Chemical Society Vol. 89, Sep 2012 (2012): 1229–34. https://doi.org/10.5281/zenodo.5769587.

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Microwave Chemistry Laboratory, Department of Chemistry, Mohanlal Sukhadia Univevsity, Udaipur-313 001, Rajasthan, India <em>E-mail</em> : pb_punjabi@yahoo.com Department of Pure & Applied Chemistry, University of Kota, Kota-324 010, Rajasthan, India college of Technology and Engineering, Maharana Pratap University of Agriculture and Technology, Udaipur-313 00 l, Rajasthan, India <em>Manuscript received 26 August 2010, revised 26 September 2011, accepted 21 December 2011</em> Condensation of oxazolone with <em>p</em>-aminobenzoic acid furnished 4-(substituted benzylidene)-4,5-dihydro-2-phe

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22

Yogesh, Murti, Arora Rashmi, and Pathak Devender. "Synthesis, characterization and in vivo anthelmintic activity of some novel N-Mannich bases of benzimidazoles." Journal of Indian Chemical Society Vol. 87, May 2010 (2010): 627–31. https://doi.org/10.5281/zenodo.5788425.

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Department of Pharmaceutical Chemistry, Rajiv Academy for Pharmacy, Mathura, N.H.# 2 Delhi-Mathura Bye-pass, P.O. Chhatikara, Mathura-281 001, Uttar Pradesh, India <em>E-mail :</em> ymurti@rediffmail.com <em>Manuscript received 1 April 2009, revised 23 September 2009, accepted 9 November 2009</em> As a part of ongoing efforts towards finding novel anthelmintic agents, <em>N</em>-Mannich bases of benzimidazole were obtained by condensation of substituted secondary amines and aldehyde in ethanol. These compounds were identified on the basis of melting point range, R<sub>f</sub> values, elemental

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23

Anita, Pati, Sahu Shankarshan, Patra Manabendra, Majumdar Poulomi, and Kumar Behera Ajaya. "Mannich reactions on spiro-s-tetrazines and their antibacterial and antifungal activities." Journal of Indian Chemical Society Vol. 89, May 2012 (2012): 637–45. https://doi.org/10.5281/zenodo.5763179.

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0rganic Synthesis Laboratory, School of Chemistry, Sambalpur University, Jyoti Vihar, Burla-768 019, Orissa, India <em>E-mail</em> : ajaykumar.behera@yahoo.com National Institute of Science & Technology, Palur Hill, Berhampur-761 068, Orissa, India <em>Manuscript received 23 July 2010, revised 05 May 2011, accepted 23 August 2011</em> A number of novel Mannich bases from spiro-<em>s</em>-tetrazines 2 have been synthesized. The reaction of a tetraazaspiroalkanes 2 underwent Mannich reaction in two different routes to afford identical target molecule 6 and 7. Spiro-<em>s</em>-tetrazines 2 on

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24

Li, Ke Hua, Bing Bing Yang, Zhi Wei Lan, Ren Fang Wang, and Tie Jun Su. "The Research of Thiosemicarbazide Modified as Acidizing Corrosion Inhibitor." Applied Mechanics and Materials 723 (January 2015): 605–9. http://dx.doi.org/10.4028/www.scientific.net/amm.723.605.

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Corrosion inhibition of N80 steel in 15% HCl was investigated in the absence and presence of different concentrations of some thiosemicarbazide derivatives (Mannich baseI, Mannich baseII) by weight loss, potentiodynamic polarization techniques. The adsorption of Mannich bases obeyed Langmuir adsorption isotherm. Both thermodynamic and activation parameters were calculated and discussed. The absorption process of Mannich base corrosion inhibitors on the surface of N80 steel is spontaneous, endothermic and entropy increase process. Polarization curves indicated that the inhibitor of Mannich base

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25

Raju, Senthil Kumar, Priyadharshini Vengadhajalaphathy, Revathy Sundaram, Sangeetha Periyasamy, Thatchayani Chinnaraj, and Praveen Sekar. "Recent advances in biological applications of mannich bases — An overview." International Journal of Pharmaceutical Chemistry and Analysis 10, no. 1 (2023): 15–27. http://dx.doi.org/10.18231/j.ijpca.2023.004.

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Mannich bases are beta-amino ketone-carrying compounds that are the end products of the Mannich reaction. The Mannich reaction is essential in the synthesis of nitrogen-containing compounds. The Mannich reaction, a nucleophilic addition reaction that forms carbon-carbon bonds, is employed in the synthesis of numerous natural products, drugs and other compounds. There are several aminoalkyl chain bearing Mannich bases with high curative value, such as fluoxetine, atropine, ethacrynic acid, trihexyphenidyl, and many others. According to the literature, Mannich bases are highly reactive and have

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26

Dimmock, J. R., and P. Kumar. "Anticancer and Cytotoxic Properties of Mannich Bases." Current Medicinal Chemistry 4, no. 1 (1997): 1–22. http://dx.doi.org/10.2174/0929867304666220309194437.

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This review outlines the chemistry and anticancer and cytotoxic properties of certain Mannich bases. It is divided into four parts. The first section summarizes briefly various investigations undertaken by other researchers of the chemical and pharmacological properties of a number of Mannich bases against neoplasms. The remaining portions of this review are summaries of work undertaken in this laboratory. The second part presents the following aspects of the anticancer properties of various Mannich bases namely differences in antileukemic activity between certain conjugated styryl ketones and

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27

Senthil Kumar Raju, Archana Settu, Archana Thiyagarajan, and Divya Rama. "Synthetic applications of biologically important Mannich bases: An updated review." Open Access Research Journal of Biology and Pharmacy 7, no. 2 (2023): 001–15. http://dx.doi.org/10.53022/oarjbp.2023.7.2.0015.

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Mannich bases are the beta-amino ketones carrying compounds. Mannich reaction is a nucleophilic addition reaction (nucleophiles such as halogen ions (I-, Br-, Cl- ), the hydroxide ion (OH- ), cyanide ion (CN-), ammonia and water, which involves the condensation of three components, viz., ammonia or a primary amine or a secondary amine or with amides, a non-enolizable aldehyde, usually formaldehyde and a compound containing an active hydrogen atom. These three compounds condense with the concomitant release of the water molecule to produce a new base known as a mannich base, in which the active

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28

SONAL, SHAH, VYAS RAJEEV, and H. MEHTA R. "Synthesis and Antibacterial Activities of some Mannich Bases from Coumarin Derivatives." Journal of Indian Chemical Society Vol. 68, Jul 1991 (1991): 411–12. https://doi.org/10.5281/zenodo.6158105.

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Department of Chemistry, Faculty of Science, M. S. University of Baroda. Baroda-390 002 <em>Manuscript received 20 March 1990, revised 15 July 1991, accepted 17 July 1991</em> Synthesis and Antibacterial Activities of some Mannich Bases from Coumarin Derivatives.

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29

Comanita, Eugenia, Gheorghe Roman, Irina Popovici, and Bogdan Comanita. "Synthesis and reactivity of some mannich bases. VIII. Studies on several mannich bases derived from ortho-hidroxyacetophenones and their conversion into oximino derivatives." Journal of the Serbian Chemical Society 66, no. 1 (2001): 9–16. http://dx.doi.org/10.2298/jsc0101009c.

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The synthesis of several Mannich bases resulting from the reaction of 2-hydroxy-4-methylacetophenone with paraformaldehyde and secondary amines is reported. Another series of products was obtained from N,N-dimethyl substituted Mannich bases by replacing the amino group with pyrrolidine. Most of the Mannich bases were transformed into oximes by treatment with hydroxylamine hydrochloride in 10% NaOH.

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Chaffin, Julie D. E., John M. Barker, and Patrick R. Huddleston. "The preparation of thiophene-based azacryptand Mannich bases." Journal of the Chemical Society, Perkin Transactions 1, no. 6 (February 15, 2002): 717–24. http://dx.doi.org/10.1039/b200479h.

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31

Babbar, Ritchu, Swikriti ., Sandeep Arora, and Thakur G. Singh. "Therapeutic Potential of Schiff and Mannich Bases of 2-Substituted Benzimidazole Analogues." INTERNATIONAL JOURNAL OF DRUG DELIVERY TECHNOLOGY 13, no. 02 (2022): 753–58. http://dx.doi.org/10.25258/ijddt.13.2.44.

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Heterocyclic scaffolds reveal extensive biological profiles, and several drugs were employed therapeutically which possess heterocyclic framework. Likewise, 2-substituted benzimidazoles play a significant role in novel drug development. In addition, Mannich and schiff base derivatives of benzimidazole acknowledged them as favorable anti-inflammatory, antimicrobial, anticancer, anthelmintic, antiviral scaffolds. Schiff bases in innumerable organic reactions show affirmative catalytic activity. The current scenario also emphasizes the spectacular activity displayed by schiff bases in the biochem

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32

Jnyanaranjan, Panda, Kumar Anjan, Mohan Sahoo Biswa, and Krishna Banik Bimal. "Microwave-assisted synthesis and evaluation of indole derivatives as potential anthelmintic agents." Journal of Indian Chemical Society Vol. 95, Nov 2018 (2018): 1283–88. https://doi.org/10.5281/zenodo.5652463.

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Department of Pharmaceutical Chemistry, Roland Institute of Pharmaceutical Sciences, Berhampur-760 010, Odisha, India Department of Pharmacy, Vikas Group of Institution, Vijayawada-521 212, Andhra Pradesh, India Community Health System of South Texas, Edinburg, Texas 78539, USA E-mail: jrpanda77@gmail.com, drbiswamohansahoo@gmail.com <em>Manuscript received 28 September 2018, accepted 01 November 2018</em> An efficient method is developed and exploited for the synthesis of indole derivatives via microwave-assisted technology. By considerin

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33

Nisheeth, Rastogi, Anil Harrison Darwin, Tripathi Diwakar, and Shukla Sarveshwar. "Synthesis and antimicrobial potential of Mannich bases of 4-chloro-3-{ 4-(chlorobenzyloxy)-benzoylhydrazono}-indolin-2-ones." Journal of Indian Chemical Society Vol. 86, Sep 2009 (2009): 991–95. https://doi.org/10.5281/zenodo.5820060.

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Department of Chemistry, Lucknow Christian Post-Graduate College, Lucknow-226 018, Uttar Pradesh, India <em>E-mail </em>: nisheethrastogi2003@yahoo.co.in Department of Chemistry, Sri Jai Narain Post-Graduate College, Lucknow-226 001, Uttar Pradesh, India <em>Manuscript received 3 March 2009, accepted 26 May 2009</em> 4-Chloro-3-{ 4-(chlorobenzyloxy)-benzoylhydrazono}-indolin-2-ones (1-4) were synthesised by the condensation of 4-(chlorobenzyloxy)-benzoylhydrazines and 4-chloroisatin. On being subjected to aminomethylation in the presence of formaldehyde and heterocyclic secondary amines, indol

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34

M., M.PATEL, та R. PATEL H. "Synthesis, Spectral, Thermal, Electrical and Antimicrobial Studies of some Complexes derived from 7 -(α-Phenyl-α-m/p-nitroanilinomethyl)-8-quinolinol". Journal of Indian Chemical Society Vol. 73, Jul 1996 (1996): 313–17. https://doi.org/10.5281/zenodo.5893168.

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Department of Chemistry, Sardar Patel University. Vallabh Vidyanagar-188 120 <em>Manuscript received  3 August 1994, revised 6 October 1994, accepted 4 November 1994</em> Metal complexes of 7-( α<em>-</em>phenyl α-<em>mlp</em> nitroanilinomethyl)-8-quinolinol (PMNAMQ/PPNAMQ) with Cu<sup>II</sup>, Ni<sup>II</sup>, Co<sup>II</sup>, Zn<sup>II</sup>, Mn<sup>II</sup>, Hg<sup>II</sup>, Cd<sup>II</sup> and UO<sup>II</sup> have been prepared and characterised. They have also been tested for their antimicrobial activities.

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35

R., R. LAKHANI, and R. PARIKH A. "Studies on lmidazolines and Benzimidazoles. Preparation and Antimicrobial Activity of 2-(2'-Aryl-6'/ 7'/-substitued-quinolin-4'-yl)-4,5-dihydroimidazoles/benzimidazoles and their Mannich Bases." Journal of Indian Chemical Society Vol. 65, Mar 1988 (1988): 197–99. https://doi.org/10.5281/zenodo.6035560.

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Department of Chemistry, Saurashtra University, Rajkot-360 005 <em>Manuscript received 2 September 1986, revised 30 November 1987, accepted 7 January 1988</em> 2-Aryl-6/7-substituted-4-quinolinecarboxylic acids have been condensed with ethylenediamine and <em>o</em>-phenylenediamines to give imidazolines and benzimidazoles, respectively. The products are condensed with formaldehyde, diethylamine and <em>N,N</em>,-diethylaminoethanol. These have been screened for their antimicrobial activity.  

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36

Tu, Nhat Quang, Clémence Richetta, Federica Putzu, et al. "Identification of HIV-1 Reverse Transcriptase-Associated Ribonuclease H Inhibitors Based on 2-Hydroxy-1,4-naphthoquinone Mannich Bases." Molecules 30, no. 3 (2025): 495. https://doi.org/10.3390/molecules30030495.

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There is a strong demand for new and efficient antiviral compounds. A series of 2-hydroxy-1,4-naphthoquinone Mannich bases were screened for their HIV-1-RNase H inhibitory activity. An HIV-1-RNase H assay was used to study the RNase H inhibition by the test compounds. Docking of active derivatives into the active site of the enzyme was carried out. Compounds 1e and 2k showed distinctly higher HIV-1-RNase H inhibitory activity (IC50 = 2.8–3.1 µM) than the known inhibitors RDS1759 and compound 13. The binding mode and possible interactions of 1e and 2k with the HIV-1-RNase H active site were det

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Subramanyam, S., Ramu Samineni, Sunil Kumar Kadiri, et al. "Synthesis and In-vivo Bioactivity Studies of Some New Hydrazide Schiff Bases and Mannich Bases of Indole Derivatives." INDIAN JOURNAL OF HETEROCYCLIC CHEMISTRY 33, no. 03 (2023): 299. http://dx.doi.org/10.59467/ijhc.2023.33.289.

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The anti-inflammatory, analgesic, and antiulcer activities of eight new hydrazide Schiff bases and eight new Mannich bases of indole derivatives were investigated. 2-Methyl-1H-indole-3-carboxylate (III) on hydrazinolysis gave 2-methyl-1H-indole-3-carbohydrazide (IV), which on reaction with aldehydes gave corresponding hydrazide Schiff bases Va–Vh. The reaction of IV with formaldehyde, different aliphatic, aromatic, and heterocyclic amines afforded the Mannich bases of indole derivatives (VIa–VIe). The results of biological studies revealed that Schiff bases with 2,4-dichlorobenzaldehyde (Vh) a

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Deo, Prem Shankar, Rhambus Rawat, and Bhushan Shakya. "Synthesis, Characterization and Antimicrobial Evaluation of Mannich Bases of 4-(Furan-2-yl-methyleneamino)-3-(2-hydroxyphenyl)-1H-1,2,4-triazole-5-thione." Journal of Nepal Chemical Society 42, no. 1 (2021): 6–15. http://dx.doi.org/10.3126/jncs.v42i1.35322.

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Triazole nucleus has drawn much attention since the last decade because of its various potent biological activities. The pharmacological application of triazoles has been widely recognized and well documented. Schiff and Mannich bases are both considered as bioactive compounds, however, there are not much of documentation about the Mannich bases as their study has begun lately. The main aim of this study was to synthesize new Mannich bases from Schiff base bearing 1,2,4-triazole nucleus to access their antimicrobial activities. The newly synthesized compounds 1,2,4-triazole-5-thione, Schiff ba

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Nisheeth, Rastogi. "Synthesis of 1-aminomethyl-3-[4´-(4´´-fluorobenzyloxy)-benzohydrazono]-5-ethylisatins as antifungal agents." Journal of Indian Chemical Society Vol. 96, Jun 2019 (2019): 699–703. https://doi.org/10.5281/zenodo.5647883.

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Dr. W. E. Bauer Research Laboratory, Department of Chemistry, Lucknow Christian Degree College, Lucknow-226 018, Uttar Pradesh, India <em>E-mail:</em> nisheethrastogi2003@gmail.com <em>Manuscript received online 10 April 2019, revised 16 May 2019, accepted 17 May 2019</em> A new series of 1-aminomethyl-3-[4´-(4´´-fluorobenzyloxy)-benzohydrazono]-5-ethylisatins (Mannich bases) has been synthesized and screened for their antifungal potential against human pathogenic fungi. The structures of the compounds have been established by means of elemental analysis and spectral data (IR

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Jha, Amitabh, Nawal K. Paul, Smriti Trikha, and T. Stanley Cameron. "Novel synthesis of 2-naphthol Mannich bases and their NMR behaviour." Canadian Journal of Chemistry 84, no. 6 (2006): 843–53. http://dx.doi.org/10.1139/v06-081.

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A novel two-step procedure involving the formation of 1-arylidene-2-tetralones from 2-tetralone and subsequent Michael addition of a cyclic secondary amine on the alkenone followed by in situ aerial oxidation was developed to produce 2-naphthol Mannich bases. A simple microwave-assisted one-pot synthesis of 2-naphthol Mannich bases was also carried out under solvent-free conditions from 2-naphthol and corresponding aldehydes and amines in the presence of p-toluenesulfonic acid. The compounds of this series displayed interesting NMR behaviour. Extensive variable-temperature NMR investigations,

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Burilov, A. R., L. I. Vagapova, M. A. Pudovik, V. D. Habicher, and A. I. Konovalov. "Novel acetal-containing calix[4]resorcinolarene-based Mannich bases." Russian Chemical Bulletin 52, no. 10 (2003): 2276–77. http://dx.doi.org/10.1023/b:rucb.0000011891.75213.01.

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Chaffin, Julie D. E., John M. Barker, and Patrick R. Huddleston. "The preparation of novel thiophene-based macrocyclic Mannich bases." Journal of the Chemical Society, Perkin Transactions 1, no. 12 (2001): 1398–405. http://dx.doi.org/10.1039/b007661i.

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Sárik, Julián Robin, István Szatmári, and Bálint Lőrinczi. "Synthesis and Transformation of Tricyclic KYNA Derivatives." International Journal of Molecular Sciences 26, no. 13 (2025): 6248. https://doi.org/10.3390/ijms26136248.

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Kynurenic acid (KYNA) derivatives condensed with an aromatic ring (tricyclic KYNA derivatives) have been successfully synthesized, and the reactivity of these analogues has been investigated in the modified Mannich reaction resulting in new Mannich bases. The N,N-dimethyl-ethylenediamine analogues of the tricyclic KYNA derivatives have also been successfully synthesized, and their reactivity in the modified Mannich reaction was investigated. The synthesized ring systems bear resemblance to molecules previously investigated as G-quadruplex binding agents. Based on this similarity, the synthesiz

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Ahmet Harmankaya, Ahmet Harmankaya, Nam k. K. l. n. Nam k K l n, Murat Beytur Murat Beytur, Yonca Y. lmaz Yonca Y lmaz, and Sevda Manap and Haydar Y. ksek Sevda Manap and Haydar Y ksek. "Synthesis, Spectroscopic Analysis, Biological Evaluation, and In Silico Studies of Novel Benzenesulfonate-Derived Schiff-Mannich Bases." Journal of the chemical society of pakistan 45, no. 4 (2023): 323. http://dx.doi.org/10.52568/001280/jcsp/45.04.2023.

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In the current study, 3-formyl phenyl benzenesulfonate is created by reacting 3-hydroxybenzaldehyde with benzene sulfonyl chloride, which is aided by triethylamine. Nine unique (Z)-3-[(3-substituted-5-oxo-1,5-dihydro-4H-1,2,4-triazol-4-yl)-iminomethyl] compounds were formed through the reaction of a manufactured 3-formyl phenyl benzenesulfonate chemical with nine 3-alkyl(aryl)-4-amino-4,5-dihydro-1H-1,2,4-triazol-5-one, as detailed in the existing literature. Phenyl benzene sulfonate (S) compounds were purchased. Through the reaction of the Schiff bases that were made a secondary amine, such a

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Muruganandam, L., and Maheswari R. "ANTI CANCER STUDIES OF SELECTIVE MANNICH BASES BY IN SILICO METHOD." International Journal of Current Pharmaceutical Research 10, no. 2 (2018): 81. http://dx.doi.org/10.22159/ijcpr.2018v10i2.25877.

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Objective: To evaluate the anticancer activities of selective Mannich bases by in silico methods.Methods: X-ray crystallographic structure of Estrogen receptor protein (PDB ID 2YAT) was downloaded from the protein data bank (PDB) and is docked with the target Mannich bases using Accelyrs Discovery Studio client version 2.5 software.Results: Based on the in silico analysis results of the target compounds with standard drug tamoxifen, the best-docked compound is identified and its anticancer activity is confirmed by using in vitro MTS analysis using Raju and Jurkat cell lines.Conclusion: The man

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Yamali, Cem, Halise Inci Gul, Tahir Cakir, Yeliz Demir, and Ilhami Gulcin. "Aminoalkylated Phenolic Chalcones: Investigation of Biological Effects on Acetylcholinesterase and Carbonic Anhydrase I and II as Potential Lead Enzyme Inhibitors." Letters in Drug Design & Discovery 17, no. 10 (2020): 1283–92. http://dx.doi.org/10.2174/1570180817999200520123510.

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Background: Phenolic Mannich bases have been reported as acetylcholinesterase (AChE) inhibitors for the medication of Alzheimer's disease. Carbonic Anhydrases (CAs) are molecular targets for anticonvulsant, diuretic and antiglaucoma drugs in the clinic. Phenolic compounds have also been mentioned as CA inhibitors. The importance of Mannich bases in drug design inspired our research group to design novel phenolic Mannic bases as potent enzyme inhibitors. Objective: In this study, novel Mannich bases, 1-(3,5-bis-aminomethyl-4-hydroxyphenyl)-3-(4- substitutedphenyl)-2-propen-1-ones (1-9), were de

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Afsah, Elsayed M., Eman M. Keshk, Abdel-Rahman H. Abdel-Rahman, and Najla F. Jomah. "Mannich Bases as Synthetic Intermediates: Convenient Synthesis of Functionalized 1,2,4-Triazepines, 1,4-Diazepines and 1,5-Diazocines." Zeitschrift für Naturforschung B 66, no. 6 (2011): 577–84. http://dx.doi.org/10.1515/znb-2011-0605.

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Transamination between the ketonic Mannich bases 1a, b and primary arylamines gave a series of ketonic sec-Mannich bases 2a - h. A variety of tetrahydro-1,2,4-triazepines 3a - f have been synthesized by treating the arylhydrazones of 2 with formaldehyde. A similar reaction with the benzenesulfonylhydrazone of 2b afforded 4. The 3-styryl-2H-1,2,4-triazepine 5 was obtained from the phenylhydrazone of 2a and cinnamaldehyde. Treatment of arylhydrazones of the 4-methoxystyryl keto base 7 with formaldehyde and cinnamaldehyde afforded the 3,4,5,6-tetrahydro-2H-1,2,4-triazepines 8a, b. Mannich reactio

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Abdulridha, Maitham M., and Moayd N. Mohammed. "DESIGN, SYNTHESIS, CHARACTERIZATION, AND ANTIBACTERIAL ACTIVITY OF SOME NEW MANNICH BASES FROM ACETYLENE ETHER." Chemical Problems 23, no. 4 (2025): 580–91. https://doi.org/10.32737/2221-8688-2025-4-580-591.

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Some new Mannich bases 3a-3f were produced by the treatment of 4,4'-(phenylmethylene)bis((prop2-yn-1-yloxy)benzene) 2a-2f with acetylene ether in the presence of formaldehyde in ethanol. The 4,4'(((phenylmethylene)bis(4,1-phenylene))bis(oxy))bis(N,N-diethylbut-2-yn-1-amine) (Mannich bases) demonstrated anticancer efficacy through docking with the C-met tyrosine kinase receptor protein, evidenced by docking scores ranging from -3.58 to -5.0 kcal/mol, in comparison to the control Crizotinib value of -6.86 kcal/mol. The new compounds were assessed for their in vitro antibacterial activity by usin

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Han, Peipei, Wenhua Zhou, Mingxia Chen, and Qiuan Wang. "Microwave-assisted Synthesis of Polymethoxychalcone Mannich Bases and Their Antiproliferative Activity." Letters in Organic Chemistry 16, no. 2 (2019): 117–21. http://dx.doi.org/10.2174/1570178615666180627110223.

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A series of eight polymethoxychalcone Mannich base derivatives 2a-2h was synthesized via the microwave-assisted Mannich reaction of natural product 2&#039;-hydroxy-3,4,4&#039;,5,6&#039;-pentamethoxychalcone (1) with various secondary amines and formaldehyde. Compared to conventional heating method (80&#176;C), the microwave-assisted method (700W, 65&#176;C) is efficient with short reaction time (0.5-1 h) and good yields (74-88%). The antiproliferative activities of eight Mannich base derivatives were evaluated in vitro on a panel of three human cancer cell lines (Hela, HCC1

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Rawat, Rhambus, Prem Shankar Deo, and Bhushan Shakya. "Synthesis, Characterization and Study of Antimicrobial Activities of Mannich Bases Incorporating 1,2,4-Triazole Nucleus." Amrit Research Journal 2, no. 01 (2021): 19–27. http://dx.doi.org/10.3126/arj.v2i01.39894.

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Heterocyclic compounds containing triazole moiety have great importance in the field of medicine, pharmaceuticals, biochemistry, biology, therapeutics, environmental science, and industry. Triazoles and their derivatives have been extensively used in the development of new drugs. Biological activities of Schiff bases are highly investigated, but Mannich bases are on the verge of their development, and they are being synthesized in large number nowadays. In this work, Mannich bases are synthesized by incorporation 1,2,4-triazole moiety through Schiff base using different amines. Mannich bases a

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