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Journal articles on the topic 'Mannich base condensation reaction'

Author: Grafiati

Published: 7 June 2025

Last updated: 2 August 2025

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1

Bischoff, Kerstin, Ulrich Girreser, Dieter Heber, and Martin Schütt. "Two-Step Synthetic Approach to 6-Substituted Pyrido[2,3-d]pyrimidine(1H,3H)-2,4-diones from 6-Amino-, 6-Alkylamino-, and 6-Arylamino-1,3-dimethyluracils." Zeitschrift für Naturforschung B 61, no. 4 (2006): 486–94. http://dx.doi.org/10.1515/znb-2006-0415.

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The Mannich reaction of 7-aryl-5,6-dihydropyrido[2,3-d]pyrimidines 3, easily accessible by condensation of 6-amino-1,3-dimethyluracil (1) with Mannich bases 2a - c, gives rise to a mixture of 7-aryl-6-(N,N-dimethylaminomethyl)pyrido[2,3-d]pyrimidines 6 and 7 as well as 1,2-bis- (7-arylpyrido[2,3-d]pyrimidin-6-yl)ethane 13 the ratio of which depends on the reaction conditions and the amine used. 6-Alkylamino-1,3-dimethyluracils 15 - 18 were converted to the corresponding 5-(3-oxo-3-phenylpropyl)uracils 19 - 22 by condensation with the Mannich base 2a. Ring closure of 19 - 22 was performed by Vi

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2

Barlin, GB, SJ Ireland, TMT Nguyen, B. Kotecka, and KH Rieckmann. "Potential Antimalarials. XVIII. Some Mono- and Di-Mannich Bases of 3-[7-Chloro(and trifluoromethyl)quinolin-4-ylamino]phenol." Australian Journal of Chemistry 46, no. 11 (1993): 1685. http://dx.doi.org/10.1071/ch9931685.

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Syntheses are reported for mono- and di-Mannich base derivatives of 3-[7-chloro(and trifluoro-methyl)quinolin-4-ylamino]phenols by Mannich reaction on 3-[7-chloro(and trifluoromethyl )-quinolin-4-ylamino]phenols or by condensation of Mannich base derivatives of 3-aminophenol, prepared from 3-nitrophenol, with the appropriate 4-chloroquinoline. The antimalarial activity of 3-(7′-chloroquinolin-4′-ylamino)-2,6-bis[ pyrrolidin-1″-ylmethyl -(or piperidin-1″-ylmethyl)]phenol against the FC-27 isolate of Plasmodium falciparum was comparable to that of chloroquine, and it was not significantly dimini

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3

Senthil Kumar Raju, Archana Settu, Archana Thiyagarajan, and Divya Rama. "Synthetic applications of biologically important Mannich bases: An updated review." Open Access Research Journal of Biology and Pharmacy 7, no. 2 (2023): 001–15. http://dx.doi.org/10.53022/oarjbp.2023.7.2.0015.

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Mannich bases are the beta-amino ketones carrying compounds. Mannich reaction is a nucleophilic addition reaction (nucleophiles such as halogen ions (I-, Br-, Cl- ), the hydroxide ion (OH- ), cyanide ion (CN-), ammonia and water, which involves the condensation of three components, viz., ammonia or a primary amine or a secondary amine or with amides, a non-enolizable aldehyde, usually formaldehyde and a compound containing an active hydrogen atom. These three compounds condense with the concomitant release of the water molecule to produce a new base known as a mannich base, in which the active

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4

Hammouda, M., A. S. El-Ahl, Y. M. El-Toukhee, and M. A. Metwally. "Reactions of Ketonic Mannich Bases with Malononitrile and Malononitrile dimer." Journal of Chemical Research 2002, no. 2 (2002): 89–94. http://dx.doi.org/10.3184/030823402103171258.

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The reaction of malononitrile with the tertiary Mannich base hydrochloride derived from acetophenone and some related compounds 1, 3, 5 and 7, in piperidine at 50°C afforded the pyrido[1,2-a]pyrimidine derivatives 2, tetrahydronaphthalene derivative 4 substituted quinolines 6 and benzopyran derivatives 8. While the condensation of malononitrile dimer with acetophenone, cyclohexanone and/ or α-tetralone Mannich bases hydrochloride 1, 3 and 9 gave the pyridine, isoquinoline and benzo[f]isoquinoline derivatives 10–12 in moderate to good yield.

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Rani, V. E., and L. K. Ravindranath. "Synthesis, Characterization and Antimicrobial Evaluation of Novel Mannich Bases Containing Pyrazole-5-One Phosphonates." Open Pharmaceutical Sciences Journal 3, no. 1 (2016): 49–55. http://dx.doi.org/10.2174/1874844901603010049.

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Background: Newly synthesised compounds of phosphonates were prepared by condensation of diethylphosphate with imine which undergoes a reaction of mannich bases with pyrazole containing schiffs base. The base was prepared by condensation of aldehyde with primary amine. These newly synthesised derivatives were characterised by spectral analysis. Objective: Mannich bases are very important to synthesize wide variety of natural products and pharmaceuticals. Method: Thin Layer Chromatography was performed on aluminum sheet of silica gel 60F254, E-Merk, Germany using iodine as visualizing agent. IR

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6

Rao, Dr Nagaraj. "MANNICH REACTION’S MESMERIZING MANIFESTATIONS." INDIAN DRUGS 61, no. 10 (2024): 5–6. https://doi.org/10.53879/id.61.10.p0005.

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After introduction of a new natural or synthetic chemical entity as a drug, the focus of research has always shifted to the modification of this chemical entity with the objective of improving ADMET properties, formulations for its efficient delivery, solubility, stability, organoleptic properties, reduction of toxicity, expansion of pharmacological range, formation of precursors, condensation products, complexation, prevention of formation of trace impurities and more. For example, the analgesic and antipyretic drug antipyrine, one of the earliest synthetic drugs, forms an intermolecular hydr

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7

Li, Yu Chao, Rui Yi Yan, Lei Wang, et al. "Synthesis of Methacrolein by Condensation of Propionaldehyde with Formaldehyde." Advanced Materials Research 396-398 (November 2011): 1094–97. http://dx.doi.org/10.4028/www.scientific.net/amr.396-398.1094.

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Methacrolein is an important intermediate in the synthesis of methyl methacrylate (MMA), which is widely used for producing acrylic plastics or producing polymer dispersions for paints and coatings. In this paper, methacrolein was synthesized by condensation of propionaldehyde with formaldehyde in the pressense of amine salt through Mannich base intermediate at the atmospheric pressure. The optimal reaction conditions were obtained. The water content in starting mixture were also investigated

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8

Mikhalyonok, S. G., V. S. Bezborodov, N. M. Kuz'menok, A. I. Savelyev, and A. S. Arol. "Synthesis of 4,6-disubstituted bicyclo[3.3.1]nona-3,6-dien-2-ones." Журнал органической химии 59, no. 7 (2023): 935–45. http://dx.doi.org/10.31857/s0514749223070078.

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Bicyclo[3.3.1]nonane system is an important structural motif observed in a diverse natural products. Here, we report a concise synthetic route exploiting aldol condensation reactions for construction bicyclo[3.3.1]nonane ring system. Our strategy employes cyclohex-2-enones bearing another carbonyl group in side chain as key structural unit. The reaction showed good results for substrates bearing electron-donating groups in aromatic substituents. Overall, the described synthesis of bicyclo[3.3.1]nona-3,6-dien-2-ones required 2 steps and only 2 building blocks (such as Mannich base and acetoacet

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9

Journal, Baghdad Science. "Synthesis and Characterization of Some New Benzimidazole Derivatives." Baghdad Science Journal 13, no. 1 (2016): 82–88. http://dx.doi.org/10.21123/bsj.13.1.82-88.

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In this paper the new starting material 2-(5-chloro-1H-benzo[d]imidazole-2-yl) aniline (1) was synthesized by the condensation reaction of 4-chloro-o-phenylenediamine and anthranilic acid .The new Mannich base derivatives were synthesized using formaldehyde and different secondary amines to synthesize a new set of benzimidazole derivatives(2-5). Also, the new Schiff-base derivatives (6-10) were synthesized from the reaction of compound (1) with various aromatic aldehydes and the closure-ring was done successfully using mercapto acetic acid to get the new thiazolidine derivatives(11-12).These n

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Gopi, Chandravadivelu, Magharla Dasaratha Dhanaraju, Konatham Pranusha, Thiyagarajan Deepan, AR Magesh, and Dhanaraju Kavitha. "Design, Synthesis, Characterization and Antitubercular Activity of Novel Benzimidazole Mannich Base Derivatives." Asian Journal of Chemistry 36, no. 4 (2024): 969–73. http://dx.doi.org/10.14233/ajchem.2024.31314.

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In present work, the newly synthesized benzimidazole Mannich base derivatives were design, synthesized and evaluated the in silico and in vitro antitubercular activity. These compounds were synthesized by condensation reaction between 1-(1H-benzo[d]imidazol-1-yl)ethanone and aliphatic/aromatic amines. The synthesized compound structures were identified by FTIR, 13C NMR, 1H NMR and mass spectroscopies. The results indicated that these derivatives have significant antitubercular activity against Mycobacterium tuberculosis (M.tb) cell wall enzyme enoyl acyl carrier protein reductase (InhA), EthR

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11

Ahmed, Alya'a J., and Mahasin F. Ahmed. "DESIGN, SYNTHESIS AND BIOLOGICAL EVALUATION OF MANNICH BASE SOME TRANSITION METAL COMPLEXES." iraqi journal of market research and consumer protection 16, no. 1 (2024): 21–37. http://dx.doi.org/10.28936/jmracpc16.1.2024.(3).

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The new mannich base ligand and its metal complexes were synthesized in ethanol medium. The mannich base is derived from the condensation reaction of morpholine and Ciprofloxacin (Cp) at room temperature. This ligand and metal complexes were characterized using elemental analysis, FT-IR, UV-Vis, and NMR spectral data, molar conductivity measurements, and melting points. Elemental analysis data show that the metal complexes formed have the general formula[Cr(L)2ClH2O] Cl.H2O, [Pt(L)2Cl2] Cl2.H2O and [Au(L)2]Cl.H2O where mannich base ligand (L) .Based on spectroscopic analytical, coordination wi

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12

Gamit, Kumar G., and Navin B. Patel. "Synthesis and in Vitro Biological Activity Study of Novel Phenol Mannich Base Analogs Containing Spiroheterocycle as Core Compound." European Journal of Advanced Chemistry Research 4, no. 3 (2023): 60–65. http://dx.doi.org/10.24018/ejchem.2023.4.3.141.

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The condensation reactions between Gabapentin lactam and phenols have been carried out in the presence of formaldehyde for the synthesis of various mannich base series. To confirm the formation of these series of newly prepared mannich bases thus synthesized, various characterization techniques have been used, such as, GC-MS, 1H-NMR, 13C-NMR and FT-IR. Further their antibacterial and antifungal activities against pathogenic bacteria have been evaluated. These compounds show promising activities against the pathogenic bacteria, hence are useful as antibacterial and antifungal active compounds.

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13

Sharma, Piush, and Charanjeet Singh. "Synthesis, characterization and biological evaluation of some novel N-Mannich bases of heterocyclic 1,3,4-thiadiazole." Journal of Drug Delivery and Therapeutics 9, no. 4-A (2019): 220–28. http://dx.doi.org/10.22270/jddt.v9i4-a.3332.

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A series of some novel N-Mannich bases of heterocyclic 1,3,4-thiadiazole were synthesized through the condensation reaction of 1,3,4-thiadiazole containing a aromatic secondary amine, aromatic aldehydes and cyclic compounds employing Mannich reaction and using conventional synthesis. All the synthesized compounds were obtained in the range of 57.41-83.3 % yield. The structures of synthesized compounds were confirmed by UV, IR, 1H NMR spectroscopy. the essential structural features responsible for interaction with receptor site are established within a suggested pharmacophore. The in vitro anti

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14

Gohari, Seyed Jamaladdin, Abdollah Javidan, Abolghasem Moghimi, Mohammad Javad Taghizadeh, and Maryam Iman. "Novel enantioselective synthesis of (S)-ketamine using chiral auxiliary and precursor Mannich base." Canadian Journal of Chemistry 97, no. 5 (2019): 331–36. http://dx.doi.org/10.1139/cjc-2017-0731.

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Ketamine has been extensively used as an anesthetic drug. Chiral auxiliaries such as tert-butanesulfinamide (TBSA) can be used for the asymmetric synthesis of (S)-ketamine. Condensation of TBSA with ketones provides tert-butanesulfinylimines in consistently high yields. The tert-butanesulfinyl group actuates the imine for nucleophilic addition, is a potent chiral directing group, and after nucleophilic addition is easily dissociated by intervention with acid solution. To prepare 2-(N-piperidinomethyl)-1-phenylcyclohexylamine (1), we started with the cyclohexanone and using Mannich reaction ach

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15

Panda, Jnyanaranjan. "Synthesis and Biological Evaluation of Some Isatin-based Mannich Bases." International Journal of Pharmaceutical Sciences and Nanotechnology 5, no. 4 (2013): 1841–46. http://dx.doi.org/10.37285/ijpsn.2012.5.4.3.

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 In this study, a series of isatin-based Mannich bases were prepared and their biological activity was evaluated. Schiff bases of isatin were synthesized by condensation of the keto group of isatin with different aromatic primary amines. The N-Mannich bases of the above Schiff bases were synthesized by reaction of the acidic imino group of isatin with formaldehyde and secondary amine. The chemical structures of the title compounds have been confirmed and elucidated by means of their physical and spectral data respectively. The compounds were tested for their possible antibacterial, analg

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16

Quiroga, Diego, and Ericsson Coy-Barrera. "Synthesis of Antifungal Heterocycle-Containing Mannich Bases: A Comprehensive Review." Organics 4, no. 4 (2023): 503–23. http://dx.doi.org/10.3390/org4040035.

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Mannich bases are a class of organic compounds usually obtained by the condensation reaction between an amine, a compound with active hydrogens, and an aldehyde. They are versatile intermediates in organic synthesis, and those compounds containing this motif find applications in pharmaceutical, agrochemical, and even material fields since they are widely known for their wide range of biological activities, including antimicrobial properties. Thus, as part of our interest in antifungal agents, this narrative review aimed to gather information from the literature on the synthesis of various repr

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17

Shukkur, A. Hamed, Athraa Thaker, Bilal Majid Rudaini, Hasanain Salah Naeem, Muntaz Abu Bakar, and Siti Aishah Hasbullah. "Synthesis and Characterization of Hexahydropyrimidines and Their New Derivatives." Sains Malaysiana 53, no. 4 (2024): 839–50. http://dx.doi.org/10.17576/jsm-2024-5304-09.

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Three new hexahydropyrimidine derivatives 1a – 1c were successfully synthesized using the Mannich-type reaction. Furthermore, the synthesis of three amino bases 2a – 2c was achieved through the reduction reaction of pyrimidine compounds using hydrazine, followed by the substitution reaction of nitro groups at diverse positions. Subsequently, one of the synthesized amino base derivatives 2c underwent conversion into seven Schiff bases 3a – 3g via a condensation reaction involving the aforementioned amino base derivative and a selection of benzaldehyde derivatives. Four amide compounds 4a – 4d h

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18

Wang, Tao, Jie Li, Hanwen Yan, Guoliang Zhang, and Shifeng Li. "Mechanism and Kinetic Study on Synthesis of Methacrolein Catalyzed by Amine/Acid." Catalysts 13, no. 5 (2023): 799. http://dx.doi.org/10.3390/catal13050799.

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Methacrolein (MAL) is an important intermediate extensively used in the manufacture of methyl methacrylate and other materials (polymers and resins). In this study, a series of secondary amines/acids were explored as catalysts for the condensation of formaldehyde and propionaldehyde to prepare MAL. It was found that the structure of the amines and acids directly affected the yield of MAL. The effect of the catalyst was closely related to the nucleophilicity of the amines as well as the steric hindrance effect, while acids also played a role as co-catalysts. Dibutylamine acetate was selected as

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19

Uprety, Bhawna, and Charmaine Arderne. "The crystal structure of the zwitterionic co-crystal of 2,4-dichloro-6-{[(3-hydroxypropyl)azaniumyl]methyl}phenolate and 2,4-dichlorophenol." Acta Crystallographica Section E Crystallographic Communications 75, no. 10 (2019): 1452–55. http://dx.doi.org/10.1107/s2056989019012544.

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The title compound, C10H13Cl2NO2·C6H4Cl2O, was formed from the incomplete Mannich condensation reaction of 3-aminopropan-1-ol, formaldehyde and 2,4-dichlorophenol in methanol. This resulted in the formation of a co-crystal of the zwitterionic Mannich base, 2,4-dichloro-6-{[(3-hydroxypropyl)azaniumyl]methyl}phenolate and the unreacted 2,4-dichlorophenol. The compound crystallizes in the monoclinic crystal system (in space group Cc) and the asymmetric unit contains a molecule each of the 2,4-dichlorophenol and 2,4-dichloro-6-{[(3-hydroxypropyl)azaniumyl]methyl}phenolate. Examination of the cryst

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El-Din, Harb. "Synthesis and reactions of 4-(p-methoxybenzyl)-6-[5,6,7,8-tetrahydro-2-naphthyl]-pyridazin-3(2H-one." Journal of the Serbian Chemical Society 64, no. 11 (1999): 663–72. http://dx.doi.org/10.2298/jsc9911663e.

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The condensation of 4-(p-methoxybenzyl)-6-[5,6,7,8-tetrahydro-2-naphthyl]- pyridazin-3(2H)-one (3), prepared by the reaction of 6-[5,6,7,8-tetrahydro-2-naphthyl]-4,5-dihydropyridazin-3(2H)-one (1) and anisaldehyde, with dimethyl sulphate, formal-dehyde and acrylonitrile, and also the formation of the Mannich base, proceeded smoothly at the 2-position to give compounds 4,5,6,7, respectively. 4-p-Methoxybenzyl-3-chloro-6-[5,6,7,8-tetrahydro-2-naphthyl]-pyridazine (9) was prepared in law yield by the action of phosphorus oxychloride on 3. The reaction of 9 with benzylamine, aniline and piperidine

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Journal, Baghdad Science. "Synthesis of New Nucleoside Analogues From Benzimidazole and Evaluation of Their Antimicrobial Activity." Baghdad Science Journal 13, no. 2 (2016): 317–32. http://dx.doi.org/10.21123/bsj.13.2.317-332.

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Our goal in this research, some new nucleoside analogues was synthesized. Starting from ?-D glucose which was converted to per acetylated ?-D gluco pyronoside then converted to active from(1-Bromo Sugar (2) as a sugar moiety.The base moiety 2-substituted benzimidazole was prepared from condensation of phenylene diamine with different aromatic aldehydes, which were subjected to amino alkylation via Mannich reaction forming new nucleobase derivatives. Condensation of nucleobase with bromo sugar through nucleophilic substitution of anomeric carbon with nitrogen forming new protected nucleoside an

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Fedotova, O. V., E. V. Kapitonova, P. V. Reshetov, and D. A. Tsimbalenko. "New directions in the condensation reactions of cyclohexanone and its Mannich base." Chemistry of Heterocyclic Compounds 33, no. 7 (1997): 773–77. http://dx.doi.org/10.1007/bf02253024.

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23

Abdulghani, Ahlam J., and Nada M. Abbas. "Synthesis Characterization and Biological Activity Study of New Schiff and Mannich Bases and Some Metal Complexes Derived from Isatin and Dithiooxamide." Bioinorganic Chemistry and Applications 2011 (2011): 1–15. http://dx.doi.org/10.1155/2011/706262.

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Two new Schiff and Mannich bases, namely, 1-Morpholinomethyl-3(1′ -N-dithiooxamide)iminoisatin (LIH) and 1-diphenylaminomethyl-3-1′-N-dithiooxamide)iminoisatin (LIIH), were prepared from condensation reaction of new Schiff base 3-(1′-N-dithiooxamide)iminoisatin (SBH) with morpholine or diphenylamine respectively in presence of formaldehyde . The structures were characterized by IR,1HNMR, mass spectrometry, and CHN analyses. Metal complexes of the two ligands were synthesized, and their structures were characterized by elemental analyses, atomic absorption, IR and UV-visible spectra, molar cond

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Romal, John Rey Apostol, and Say Kee Ong. "Single-Step Fabrication of a Dual-Sensitive Chitosan Hydrogel by C-Mannich Reaction: Synthesis, Physicochemical Properties, and Screening of its Cu2+ Uptake." Processes 11, no. 2 (2023): 354. http://dx.doi.org/10.3390/pr11020354.

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Uncovering the value of waste materials is one of the keys to sustainability. In this current work, valorization of chitosan was pursued to fabricate a novel modified chitosan functional hydrogel using a process-efficient protocol. The fabrication proceeds by a one-pot and single-step C-Mannich condensation of chitosan (3% w/v), glutaraldehyde (20 eq.), and 4-hydroxycoumarin (40 eq.) at 22 °C in 3% v/v acetic acid. The Mannich base modified chitosan hydrogel (CS-MB) exhibits a dual-responsive swelling behavior in response to pH and temperature that has not been observed in any other hydrogel s

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FEDOTOVA, O. V., E. V. KAPITONOVA, P. V. RESHETOV, and D. A. TSIMBALENKO. "ChemInform Abstract: New Courses of Condensation Reactions of Cyclohexanone and Its Mannich Base." ChemInform 29, no. 3 (2010): no. http://dx.doi.org/10.1002/chin.199803050.

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Pranay, Shah, I. Patel R., and J. Vyas P. "Preparation and Biological Screening of Novel Heterocyclic Compounds." International Journal of Trend in Scientific Research and Development 3, no. 3 (2019): 632–36. https://doi.org/10.31142/ijtsrd22815.

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The Pyrimidone derivatives say, N arylidine 6 methyl 2 oxo 4 phenyl 1,2,3, 4 tetrahydropyrimidonecarbohydrazides 2a e were synthesized by condensation of Benzaldehyde derivatives with 6 Methyl 2 oxo 4 phenyl 1,2,3,4 tetrahydro pyrimidone carbohydrazides 1 in good yield. The so called hydrazone were cyclocondensed with succinic anhydride to afford 1 6 methyl 2 oxo 4 phenyl 1,2,3, 4 tetrahydropyrimidone 5 carboxamido 5 oxo 2 aryl pyrrolidine 3 carboxylic acid 3a e . These 3a e on Mannich reaction with formaldehyde and morpholine offered 2 aryl 1 6 methyl 2 oxo 4 phenyl 1, 2, 3, 4 tetrahydropyrim

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Kavitha, Devaraj, Velayutham Gurunathan, Karumalaiyan Palanisamy, and Sangilimuthu Aruna Devi. "SYNTHESIS, SPECTROSCOPIC CHARACTERISATION OF NOVEL METAL COMPLEXES OF AN INNOVATIVE CLASS OF MANNICH BASE AS LARVICIDES AGAINST Culex quinquefasciatus AND DOCKING STUDIES." RASAYAN Journal of Chemistry 18, no. 02 (2025): 1138–53. https://doi.org/10.31788/rjc.2025.1829139.

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Lymphatic filariasis and malaria are among the utmost prevalent recognised parasitic illnesses spread by mosquitoes globally. Mosquito-borne diseases are estimated to cause around 1 million fatalities annually. Such illnesses are managed with the application of pesticides; yet, these may adversely affect non-target organisms. Consequently, we aimed to identify an appropriate larvicidal molecule to substitute pesticides by assessing the larvicidal efficacy of Mannich base ligand (L1) and its corresponding complexes (1-5) towards Culex quinquefasciatus. Five novel complexes were synthesised by u

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Utomo, Suryadi Budi, Jumina Jumina, Dwi Siswanta, and Mustofa Mustofa. "SYNTHESIS OF TETRAKIS-N,N,N-TRIMETHYLAMMONIUMMETHYL-C-3,4-DIMETHOXYPHENYLCALIX[4]RESORCINARENE IODIDE BASED VANILLIN AND ITS ANTIDOTE ACTIVITY FOR CHROMIUM(VI) INTOXICATION." Indonesian Journal of Chemistry 13, no. 2 (2013): 158–65. http://dx.doi.org/10.22146/ijc.21299.

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A research has been conducted to synthesize tetrakis-N,N,N-trimethylammoniummethyl-C-3,4-dimethoxyphenylcalix[4]resorcinarene iodide from vanillin and investigate its antidote capability for Cr(VI) intoxication. The synthesis was carried out in four steps i.e. (1) O-alkylation of 4-hydroxy-3-methoxybenzaldehyde, (2) HCl-catalyzed condensation of 3,4-dimethoxybenzaldehyde with resorcinol, (3) Mannich reaction of C-3,4-dimethoxyphenylcalix[4]resorcinarene with formaldehyde and dimethylamine in the presence of HCl to yield tetrakis-N,N-dimethylaminomethyl-C-3,4-dimethoxyphenylcalix[4]resorcinaren

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Abaas, Hadeel J., and Mohamad J. Al-Jeboori. "New dimeric complexes with semicarbazone mannich-based ligand; formation, structural investigation and biological activity." Bionatura 8, no. 2 (2023): 1–13. http://dx.doi.org/10.21931/rb/2023.08.02.15.

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The formation of a new semicarbazone Schiff-base ligand (E)-2-(2-(phenyl(2-phenylhydrazinyl)- methyl)cyclohexylidene)hydrazine-1-carboxamide (HL) and its complexes are reported. The new ligand was prepared from the condensation of the Mannich-base 2-(phenyl(2-phenylhydrazinyl)methyl)cyclohexan-1-one (M) with the semicarbazide. A series of metal complexes were prepared by the reaction of the ligand with the metal chlorides of Cr(III), Mn(II), Co(II), Ni(II), Cu(II)), Zn(II) and Cd(II). The structure of the ligand and its complexes were elucidated through analytical and spectroscopic techniques.

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FARAH MUAIAD IBRAHIM. "Synthesis and Characterization of Fe (II), Co (II), Ni (II), Cu (II), Cd (II) Mono-Complexes with Mannich Base 4- hydroxy- 3-(4'-morpholinyl methyl) quinoline." Journal of the College of Basic Education 18, no. 74 (2023): 83–94. http://dx.doi.org/10.35950/cbej.v18i74.9687.

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Mannich bases have rececived great attention in recent years because of their proven antimalarial, antifungal and anticancer activities, coordination certain metal ions to them have interested use in synthesizing and studying structural aspects of metal complexes with oxygen and nitrogen donor ligands. The chelate ligand 4-hydroxy-3-(4'-morpholinyl methyl) quinoline was prepared by condensation of the formaldehyde with morpholine and 4- hydroxyquinoline in ethanol. A methanolic solution of the prepared ligand was reacted with a methanolic solution containing metal ions Fe (II), Co

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R., Dhachana Moorthy* C. A. Suresh Kumar R. Lalith Kumar M. Ramya P. B. Sholarajan. "Design And Insilico Investigation of Novel Kojic Acid Isoniazid Derivatives as Potent Anti Tuberculosis Agents." International Journal of Pharmaceutical Sciences 3, no. 3 (2025): 625–35. https://doi.org/10.5281/zenodo.14995009.

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Worldwide, TB is the second leading infectious killer after COVID-19, HIV and AIDS. In 2022, an estimated 10.6 million people fell ill with tuberculosis (TB) worldwide, including 5.8 million men, 3.5 million women and 1.3 million children. Kojic acid is naturally occurring via the fermentation process, kojic acid has a wide range of biological activities. According to certain reviews of the literature, kojic acid likewise has little effect  against  tuberculosis disease and Kojic acid also has a low toxicity profile. Isoniazid is active against enoyl reductase so inhibit the action o

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Patel, H. M., D. P. Rajani, M. G. Sharma, and H. G. Bhatt. "Synthesis, Molecular Docking and Biological Evaluation of Mannich Products Based on Thiophene Nucleus using Ionic Liquid." Letters in Drug Design & Discovery 16, no. 2 (2018): 119–26. http://dx.doi.org/10.2174/1570180815666180502123743.

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Background: We report here an efficient synthesis of new Mannich products 4(a-m) in excellent yields via multi-component reaction for the condensation of 5-bromothiophene- 2-carboxaldehyde (5-BT-2C), 2,4-dihydroxybenzophenone (2,4-DHBP) and primary/secondary amine derivative using Ethyl Ammonium Nitrate (EAN) as ionic liquid, which is reusable and plays an important role as a catalyst under 800C. </P><P> Methods: All synthesized compounds were characterized by FT-IR, 1H-NMR, 13C-NMR spectra. All compounds were screened for their in vitro antibacterial, antifungal and antituberculos

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Mukhtorov, Loik G., Yevgenia V. Ivanova, Igor' V. Blokhin, et al. "SYNTHESIS AND STRUCTURE OF NEW DERIVATIVES OF 10-R-4-METHYL-1,8-DINITRO-3-OXA-5,10-DIAZATRICYCLO[6.3.1.02.6]DODECA-2(6),4-DIENE." IZVESTIYA VYSSHIKH UCHEBNYKH ZAVEDENII KHIMIYA KHIMICHESKAYA TEKHNOLOGIYA 63, no. 1 (2019): 4–10. http://dx.doi.org/10.6060/ivkkt.20206301.5944.

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The spatial and electronic structure of 2-methyl-5,7-dinitrobenzo[d]oxazole, which is the substrate for the synthesis of hydride σ-adducts, was studied by the DFT/B3LYP/aug-cc-pVDZ method. Analysis of the charges on the atoms showed that the largest positive NBO charge is concentrated on the carbon atom C2 of the oxazole ring, while the carbon atoms C4 and C6 annelated benzene nucleus have the highest Mulliken charges both in the gas phase and in water. Thus, it has been established that a rigid base, a methoxide ion, is attached to the carbon atom C2, which is a hard reaction center, and a re

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34

Ismail, Magda M. F., Dalia H. S. Soliman, Mona H. Abd Elmoniem, and Ghehad A. R. Abdel Jaleel. "Synthesis, Molecular Modeling of Novel Substituted Pyridazinones and their Vasorelaxant Activities." Medicinal Chemistry 17, no. 2 (2020): 171–86. http://dx.doi.org/10.2174/1573406416666200327191100.

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Background: Hypertension, one of the most common cardiovascular diseases that can cause coronary disease, stroke, myocardial infarction, and sudden death, it is the major contributor to cardiac failure as well as renal insufficiency. Objectives: As there are many cardio-active pyridazinone-base derivatives in clinical use, therefore, we aimed to synthesize a new series of pyridazin-3-ones and evaluate their vasorelaxant activity. Methods: A new series of synthesized compounds were carried out first by the synthesis of 6- flouroarylpyridazinones by cyclization of 3-(4-flourobenzoyl) propionic a

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Petrova, Anastasiya V., Denis A. Babkov, Elmira F. Khusnutdinova та ін. "α-Glucosidase Inhibitors Based on Oleanolic Acid for the Treatment of Immunometabolic Disorders". Applied Sciences 13, № 16 (2023): 9269. http://dx.doi.org/10.3390/app13169269.

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Using oleanolic acid as a starting compound, a series of new oleanane-type triterpenic derivatives were synthesized via O-acylation (with nicotinic, isonicotinic, and methoxycinnamic acid acyl chlorides), N-amidation (with cyclic- or polyamines), the Mannich reaction (with secondary cyclic amines), and Claisen–Schmidt condensation (with aromatic aldehydes), and their potencies as treatments for immunometabolic disorders were investigated. The compounds were evaluated against α-glucosidase and PTP1B enzymes and LPS-stimulated murine macrophages. It was found that the target compounds are highly

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36

Xing, Yunliang, Xianru He, Rui Yang, Kan Zhang, and Shengfu Yang. "Design of High-Performance Polybenzoxazines with Tunable Extended Networks Based on Resveratrol and Allyl Functional Benzoxazine." Polymers 12, no. 12 (2020): 2794. http://dx.doi.org/10.3390/polym12122794.

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A novel resveratrol-based bio-benzoxazine monomer (RES-al) containing an allyl group has been synthesized using resveratrol, allylamine, and paraformaldehyde via Mannich condensation reaction, and its chemical structures have been characterized by FT-IR spectroscopy and NMR techniques. The polymerization behavior of this benzoxazine resin has been investigated using in situ FT-IR and differential scanning calorimeter (DSC) measurements, and the thermal-mechanical properties of its corresponding polybenzoxazines are evaluated by DMA and TGA. We show that by controlling the curing process of the

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Mohammed, Issam A., Mahmood Ahmed, Rabia Ikram, Muhammad Muddassar, Muhammad Abdul Qadir, and Khalijah Binti Awang. "Synthesis of 1,3-benzoxazines Based on 2,4,4-trimethyl-7,2’,4’-trihydroxy Flavan: Antibacterial, Anti-inflammatory, Cyclooxygenase-2 Inhibition and Molecular Modelling Studies." Letters in Drug Design & Discovery 16, no. 1 (2018): 58–65. http://dx.doi.org/10.2174/1570180815666180420100922.

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Background: In the present study, the formation of 2, 4, 4-trimethyl-7,2’4’-trihydroxy flavan has been used as the key feature for the formation of new 1,3-benzoxazines. This reaction was carried out via Mannich-condensation reaction, the 7-hydroxy group of flavan was reacted with different primary amines in the presence of formaldehyde. Methods: All the synthesized compounds were characterized on the basis of FT-IR, NMR, MS and elemental analysis (CHN). Disk diffusion and 96-well plate assay methods were employed for the zone of inhibition and minimum inhibitory concentration determination, r

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Jnyanaranjan, Panda, Kumar Anjan, Mohan Sahoo Biswa, and Krishna Banik Bimal. "Microwave-assisted synthesis and evaluation of indole derivatives as potential anthelmintic agents." Journal of Indian Chemical Society Vol. 95, Nov 2018 (2018): 1283–88. https://doi.org/10.5281/zenodo.5652463.

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Department of Pharmaceutical Chemistry, Roland Institute of Pharmaceutical Sciences, Berhampur-760 010, Odisha, India Department of Pharmacy, Vikas Group of Institution, Vijayawada-521 212, Andhra Pradesh, India Community Health System of South Texas, Edinburg, Texas 78539, USA E-mail: jrpanda77@gmail.com, drbiswamohansahoo@gmail.com <em>Manuscript received 28 September 2018, accepted 01 November 2018</em> An efficient method is developed and exploited for the synthesis of indole derivatives via microwave-assisted technology. By considerin

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Raorane, Chaitany Jayprakash, Thirukumaran Periyasamy, Rajesh Haldhar, Shakila Parveen Asrafali, Vinit Raj, and Seong-Cheol Kim. "Synthesis of Bio-Based Polybenzoxazine and Its Antibiofilm and Anticorrosive Activities." Materials 16, no. 6 (2023): 2249. http://dx.doi.org/10.3390/ma16062249.

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Candida albicans are highly widespread pathogenic fungi in humans. Moreover, its developed biofilm causes serious clinical problems, leading to drug failure caused by its inherent drug tolerance. Hence, the inhibition of biofilm formation and virulence characteristics provide other means of addressing infections. Polymer composites (PCs) derived from natural products have attracted increasing interest in the scientific community, including antimicrobial applications. PCs are a good alternative approach to solving this challenge because of their excellent penetration power inside biofilms. The

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Asrafali, Shakila Parveen, Thirukumaran Periyasamy, Gazi A. K. M. Rafiqul Bari, and Seong-Cheol Kim. "Flexible Composite Hydrogels Based on Polybenzoxazine for Supercapacitor Applications." Gels 10, no. 3 (2024): 197. http://dx.doi.org/10.3390/gels10030197.

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Polybenzoxazines (Pbzs) are advanced forms of phenolic resins that possess many attractive properties, including thermal-induced self-curing polymerization, void-free polymeric products and absence of by-product formation. They also possess high Tg (glass transition temperature) and thermal stability. But the produced materials are brittle in nature. In this paper, we present our attempt to decrease the brittleness of Pbz by blending it with polyvinylalcohol (PVA). Benzoxazine monomer (Eu-Ed-Bzo) was synthesized by following a simple Mannich condensation reaction. The formation of a benzoxazin

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Rohimi, Nurfatin Farhanah, Rasidi Roslan, Nurjannah Salim, Siti Noor Hidayah Mustapha, Sarani Zakaria, and Chin Hua Chia. "Lignin-Based Polybenzoxazine Derived from Empty Fruit Bunch Fibers with Good Thermal and Mechanical Properties." Materials Science Forum 981 (March 2020): 121–26. http://dx.doi.org/10.4028/www.scientific.net/msf.981.121.

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In this study, a renewable phenolic component was synthesized using empty fruit bunch fibers via microwave-assisted liquefaction known as Liquefied Empty Fruit Bunch (LEFB). LEFB can be used as phenolic derivative to replace petroleum-based phenol as it contains aromatic group in lignin that can be used as starting materials to synthesis polybenzoxazine resins. A Lignin-based benzoxazine (L-PBz) has been synthesized using a solventless approach from the reaction of LEFB, furfurylamine as the amine component and paraformaldehyde via Mannich condensation reaction. Two different ratios of LEFB:fu

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Durran, Sean E., Mark R. J. Elsegood, Neil Hawkins, Martin B. Smith, and Salem Talib. "New functionalised ditertiary phosphines via phosphorus based Mannich condensation reactions." Tetrahedron Letters 44, no. 28 (2003): 5255–57. http://dx.doi.org/10.1016/s0040-4039(03)01273-5.

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Kumar, Prashant, Kieran Griffiths, Smaragda Lymperopoulou, and George E. Kostakis. "Tetranuclear Zn2Ln2 coordination clusters as catalysts in the Petasis borono-Mannich multicomponent reaction." RSC Advances 6, no. 82 (2016): 79180–84. http://dx.doi.org/10.1039/c6ra17209a.

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We report for the first time the efficiency of heteronuclear Zn/Ln coordination clusters (CCs) as catalysts for the multicomponent Mannich-type condensation that involves amines, aldehydes and boronic acids, known as the Petasis borono-Mannich (RBR) reaction.

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Purwono, Bambang, and Estiana E. P. Daruningsih. "NUCHLEOPHILIC SUBSTITUTION REACTION OF CYANIDE AND METHOXYDE IONS TO QUATERNARY MANNICH BASE FROM VANILLIN." Indonesian Journal of Chemistry 7, no. 1 (2010): 58–60. http://dx.doi.org/10.22146/ijc.21713.

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The nucleophilic substitution reaction to quaternary Mannich base from vanillin has been investigated. Mannich reaction to vanillin was carried out by refluxing mixture of vanillin, formaldehyde and dimethyl amine. Quaternary ammonium halide salt was obtained from reaction of Mannich vanillin base with methyl iodide in THF solvents and yielded 93.28%. Nucleophilic substituion to the halide salts with cyanide nucleophile produced 4-hidroxy-3-methoxy-5-(cyano)methylbenzaldehyde in 54.39% yield, with methoxyde ion obtained 4-hidroxy- 3-methoxy-5-(methoxy)-methyl-benzaldehide in 67.80% yield. The

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Purwono, Bambang, and Estiana R. P. Daruningsih. "NUCLEOPHILIC SUBSTITUTION REACTION OF CYANIDE AND METHOXYDE IONS TO QUATERNARY MANNICH BASE FROM VANILLIN." Indonesian Journal of Chemistry 5, no. 3 (2010): 203–6. http://dx.doi.org/10.22146/ijc.21789.

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The nucleophilic substitution reaction to quaternary Mannich base from vanillin has been investigated. Mannich reaction to vanillin was carried out by refluxing mixture of vanillin, formaldehyde and dimethyl amine. Quaternary ammonium halide salt was obtained from reaction of Mannich vanillin base with methyl iodide in THF solvents and yielded 93.28 %. Nucleophilic substituion to the halide salts with cyanide nucleophile produced 4-hidroxy-3-methoxy-5-(cyano)methylbenzaldehyde in 54.39% yield. Reaction with methoxyde ion yielded 4-hydroxy- 3-methoxy-5-(methoxy) -methylbenzaldehyde in 67.80% yi

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Chen, Zhen-Zhen, Dong-Zhao Yang, Ying-Ying Dong, Mei Chi, Shou-Zhi Pu та Qi Sun. "Hf(OTf)4-Catalyzed Three-Component Synthesis of N-Carbamate-Protected β-Amino Ketones". Molecules 27, № 3 (2022): 1122. http://dx.doi.org/10.3390/molecules27031122.

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Hafnium(IV) triflate (Hf(OTf)4) has been identified as a potent catalyst for the direct three-component synthesis of β-carbamate ketones. This new method, featuring a low catalyst loading, fast reaction rate, and solvent-free conditions, provided facile access to a diversity of carbamate-protected Mannich bases. A mechanistic investigation indicated that the three-component reaction proceeds via sequential aldol condensation and aza-Michael addition, but not the Mannich-type pathway.

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Bikas, Rahman, Marzieh Emami, Katarzyna Ślepokura, and Nader Noshiranzadeh. "Preparing Mn(iii) salen-type Schiff base complexes using 1,3-oxazines obtained by Mannich condensation: towards removing ortho-hydroxyaldehydes." New Journal of Chemistry 41, no. 18 (2017): 9710–17. http://dx.doi.org/10.1039/c7nj01562c.

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Barlin, GB, TMT Nguyen, B. Kotecka, and KH Rieckmann. "Potential Antimalarials. XV. Di-Mannich Bases of 2-(7'-Chloroquinolin-4'-ylamino)phenol and 2-[7'-Bromo( and trifluoromethyl)-1',5'-naphthyridin-4'-ylamino]phenol." Australian Journal of Chemistry 45, no. 10 (1992): 1651. http://dx.doi.org/10.1071/ch9921651.

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A total of 26 di-Mannich base derivatives of 2-(7'-chloroquinolin-4'-ylamino)phenol and 2-[7'- bromo (and trifluoromethyl )-1',5'-naphthyridin-4'-ylino]phenol, such as 2-(7'-chloroquinolin- 4'-ylamino)-4,6-bis( piperidin-1″-ylmethyl )phenol, together with some 3- and 5-methyl derivatives and mono-Mannich analogues, have been prepared by condensation of the 4-chloro heterocycle with the appropriate Mannich base derivatives of 2-aminophenols. In in vitro tests against Plasmodium falciparum, many of the di-Mannich base derivatives of 2-(7'-chloroquinolin-4'-ylarnino)phenol exhibited activity comp

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Zhang, Tong, Jun Wang, Tiantian Feng, et al. "A novel high performance oxazine derivative: design of tetrafunctional monomer, step-wise ring-opening polymerization, improved thermal property and broadened processing window." RSC Advances 5, no. 42 (2015): 33623–31. http://dx.doi.org/10.1039/c5ra02839f.

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A novel tetrafunctional oxazine monomer containing benzoxazine and fluorene-oxazine was prepared for the first time using a Mannich condensation reaction of 2,7-dihydroxy-9,9-bis-(4-hydroxyphenyl)fluorene with paraformaldehyde and n-butylamine.

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Möhrle, Hans, та Georg Keller. "α-Dicarbonylmonoxime als Nucleophile und Nachbargruppen / α-Dicarbonylmonoximes as Nucleophiles and Neighbour Groups". Zeitschrift für Naturforschung B 54, № 5 (1999): 632–42. http://dx.doi.org/10.1515/znb-1999-0511.

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The α-dicarbonylmonooximes 1 and 11 do not react as simple “CH-acidic-compounds” in the Mannich condensation. In a concerted reaction with aminals in absolute dioxane they give rise to the products 4a - e and 12a - e with better practicability and much higher yields compared with the conventional method. The Mannich bases with a cyclic amine part show in the dehydrogenation, using mercury-EDTA, a neighbouring group participation of the oxime in type 4 and of the oxime or amide function in 12 yielding cyclized products. For the reaction a plausible mechanism is proposed.

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