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Academic literature on the topic 'Mannich bases'

Author: Grafiati

Published: 4 June 2021

Last updated: 12 June 2025

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Journal articles on the topic "Mannich bases"

1

Yamali, Cem, Halise Inci Gul, Tahir Cakir, Yeliz Demir, and Ilhami Gulcin. "Aminoalkylated Phenolic Chalcones: Investigation of Biological Effects on Acetylcholinesterase and Carbonic Anhydrase I and II as Potential Lead Enzyme Inhibitors." Letters in Drug Design & Discovery 17, no. 10 (2020): 1283–92. http://dx.doi.org/10.2174/1570180817999200520123510.

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Background: Phenolic Mannich bases have been reported as acetylcholinesterase (AChE) inhibitors for the medication of Alzheimer's disease. Carbonic Anhydrases (CAs) are molecular targets for anticonvulsant, diuretic and antiglaucoma drugs in the clinic. Phenolic compounds have also been mentioned as CA inhibitors. The importance of Mannich bases in drug design inspired our research group to design novel phenolic Mannic bases as potent enzyme inhibitors. Objective: In this study, novel Mannich bases, 1-(3,5-bis-aminomethyl-4-hydroxyphenyl)-3-(4- substitutedphenyl)-2-propen-1-ones (1-9), were designed to discover new and potent AChE inhibitors for the treatment of Alzheimer's disease and also to report their carbonic anhydrase inhibitory potency against the most studied hCA I and hCA II isoenzymes with the hope to find out promising enzyme inhibitors. Methods: Mannich bases were synthesized by the Mannich reaction. The structures of the compounds were elucidated by 1H NMR, 13C NMR, and HRMS. Enzyme inhibitory potency of the compounds was evaluated spectrophotometrically towards AChE, hCA I and hCA II enzymes. Results and Discussion: The compounds showed inhibition potency in nanomolar concentrations against AChE with Ki values ranging from 20.44±3.17 nM to 43.25±6.28 nM. They also showed CAs inhibition potency with Ki values in the range of 11.76±1.29-31.09±2.7 nM (hCA I) and 6.08 ± 1.18-23.12±4.26 nM (hCA II). Compounds 1 (hCA I), 5 (hCA II), and 4 (AChE) showed significant inhibitory potency against the enzymes targeted. Conclusion: Enzyme assays showed that Mannich derivatives might be considered as lead enzyme inhibitors to design more selective and potent compounds targeting enzyme-based diseases.

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Hajiyeva, G. E., E. H. Mammadbayli, S. I. Ibrahimli, and I. A. Jafarov. "NORBORNENE-CONTAINING MANNICH BASES ON THE BASIS OF ALIPHATIC AMINES." Azerbaijan Chemical Journal, no. 3 (2018): 50–56. http://dx.doi.org/10.32737/0005-2531-2018-3-50-56.

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Bala, Suman, Neha Sharma, Anu Kajal, Sunil Kamboj, and Vipin Saini. "Mannich Bases: An Important Pharmacophore in Present Scenario." International Journal of Medicinal Chemistry 2014 (November 12, 2014): 1–15. http://dx.doi.org/10.1155/2014/191072.

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Mannich bases are the end products of Mannich reaction and are known as beta-amino ketone carrying compounds. Mannich reaction is a carbon-carbon bond forming nucleophilic addition reaction and is a key step in synthesis of a wide variety of natural products, pharmaceuticals, and so forth. Mannich reaction is important for the construction of nitrogen containing compounds. There is a number of aminoalkyl chain bearing Mannich bases like fluoxetine, atropine, ethacrynic acid, trihexyphenidyl, and so forth with high curative value. The literature studies enlighten the fact that Mannich bases are very reactive and recognized to possess potent diverse activities like anti-inflammatory, anticancer, antifilarial, antibacterial, antifungal, anticonvulsant, anthelmintic, antitubercular, analgesic, anti-HIV, antimalarial, antipsychotic, antiviral activities and so forth. The biological activity of Mannich bases is mainly attributed to α, β-unsaturated ketone which can be generated by deamination of hydrogen atom of the amine group.

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Panda, Jnyanaranjan. "Synthesis and Biological Evaluation of Some Isatin-based Mannich Bases." International Journal of Pharmaceutical Sciences and Nanotechnology 5, no. 4 (2013): 1841–46. http://dx.doi.org/10.37285/ijpsn.2012.5.4.3.

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 In this study, a series of isatin-based Mannich bases were prepared and their biological activity was evaluated. Schiff bases of isatin were synthesized by condensation of the keto group of isatin with different aromatic primary amines. The N-Mannich bases of the above Schiff bases were synthesized by reaction of the acidic imino group of isatin with formaldehyde and secondary amine. The chemical structures of the title compounds have been confirmed and elucidated by means of their physical and spectral data respectively. The compounds were tested for their possible antibacterial, analgesic and anti-inflammatory activities by the standard methods. Among the tested compounds, the compound containing the chloro group showed significant biological activity. These pilot studies demonstrate the usefulness of isatin-based Mannich bases. 

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Dimmock, J. R., and P. Kumar. "Anticancer and Cytotoxic Properties of Mannich Bases." Current Medicinal Chemistry 4, no. 1 (1997): 1–22. http://dx.doi.org/10.2174/0929867304666220309194437.

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This review outlines the chemistry and anticancer and cytotoxic properties of certain Mannich bases. It is divided into four parts. The first section summarizes briefly various investigations undertaken by other researchers of the chemical and pharmacological properties of a number of Mannich bases against neoplasms. The remaining portions of this review are summaries of work undertaken in this laboratory. The second part presents the following aspects of the anticancer properties of various Mannich bases namely differences in antileukemic activity between certain conjugated styryl ketones and the related Mannich bases, intramolecular cyclization of various acyclic Mannich bases and the effect on anticancer activity of such a process, prodrug approaches with a view to obtaining preferential toxicity to cancerous rather than normal cells and finally the effect on antineoplastic properties of introducing a second basic centre into these compounds. The third section summarizes the promising in vitro activities of different acyclic Mannich bases against the WiDr human colon cancer cells and the preparation of a group of Mannich bases which are effective against certain drug resistant malignant cells. The evidence for and evaluations of a theory proposed by one of the authors called sequential cytotoxicity is presented followed by a description of the very high cytotoxicity of some 4-piperidones; a group of compounds which may be regarded as cyclic Mannich bases. Finally, some biochemical properties of certain of these compounds are outlined especially with reference to their causing inhibition of respiration in mitochondria, particularly in those organelles obtained from neoplastic tissue.

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SETHI, RITCHU, SANDEEP ARORA, NEELAM JAIN, and SANDEEP JAIN. "Mannich Bases of 2-Substituted Benzimidazoles - A Review." JOURNAL OF PHARMACEUTICAL TECHNOLOGY, RESEARCH AND MANAGEMENT 3, no. 2 (2015): 97–111. http://dx.doi.org/10.15415/jptrm.2015.32008.

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Deo, Prem Shankar, Rhambus Rawat, and Bhushan Shakya. "Synthesis, Characterization and Antimicrobial Evaluation of Mannich Bases of 4-(Furan-2-yl-methyleneamino)-3-(2-hydroxyphenyl)-1H-1,2,4-triazole-5-thione." Journal of Nepal Chemical Society 42, no. 1 (2021): 6–15. http://dx.doi.org/10.3126/jncs.v42i1.35322.

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Triazole nucleus has drawn much attention since the last decade because of its various potent biological activities. The pharmacological application of triazoles has been widely recognized and well documented. Schiff and Mannich bases are both considered as bioactive compounds, however, there are not much of documentation about the Mannich bases as their study has begun lately. The main aim of this study was to synthesize new Mannich bases from Schiff base bearing 1,2,4-triazole nucleus to access their antimicrobial activities. The newly synthesized compounds 1,2,4-triazole-5-thione, Schiff base (4) and Mannich bases (5a & 5b) were characterized by spectral techniques like UV, FT-IR, and NMR. Mannich bases were tested against various bacterial (gm +ve and gm –ve) as well as fungal strains. The synthesized Mannich bases showed good to moderate activities against the tested bacterial and fungal strains.

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Comanita, Eugenia, Gheorghe Roman, Irina Popovici, and Bogdan Comanita. "Synthesis and reactivity of some mannich bases. VIII. Studies on several mannich bases derived from ortho-hidroxyacetophenones and their conversion into oximino derivatives." Journal of the Serbian Chemical Society 66, no. 1 (2001): 9–16. http://dx.doi.org/10.2298/jsc0101009c.

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The synthesis of several Mannich bases resulting from the reaction of 2-hydroxy-4-methylacetophenone with paraformaldehyde and secondary amines is reported. Another series of products was obtained from N,N-dimethyl substituted Mannich bases by replacing the amino group with pyrrolidine. Most of the Mannich bases were transformed into oximes by treatment with hydroxylamine hydrochloride in 10% NaOH.

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Li, Ke Hua, Bing Bing Yang, Zhi Wei Lan, Ren Fang Wang, and Tie Jun Su. "The Research of Thiosemicarbazide Modified as Acidizing Corrosion Inhibitor." Applied Mechanics and Materials 723 (January 2015): 605–9. http://dx.doi.org/10.4028/www.scientific.net/amm.723.605.

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Corrosion inhibition of N80 steel in 15% HCl was investigated in the absence and presence of different concentrations of some thiosemicarbazide derivatives (Mannich baseI, Mannich baseII) by weight loss, potentiodynamic polarization techniques. The adsorption of Mannich bases obeyed Langmuir adsorption isotherm. Both thermodynamic and activation parameters were calculated and discussed. The absorption process of Mannich base corrosion inhibitors on the surface of N80 steel is spontaneous, endothermic and entropy increase process. Polarization curves indicated that the inhibitor of Mannich bases are the mixed corrosion-controlling one which inhibited anodie corrosion. The results obtained from weight loss, Potentiodynamic polarization are in good agreement.

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Journal, Baghdad Science. "Synthesis And Characterization Of Some New Acetylenic Mannich Bases Based On Biphenyl – 4,4 - Dithiol." Baghdad Science Journal 10, no. 3 (2013): 712–23. http://dx.doi.org/10.21123/bsj.10.3.712-723.

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One of the most important , compound which have active hydrogen is the compound possessing (thiol group) Biphenyl-4,4-dithiol is agood example utilized in a wide field for preparation mannich bases , avariety of new acetylenic mannich bases have been Synthesized and all proposed structure were Supported by FTIR , 1H – NMR, 13C-NMR , Elemental analysis and microbial study .

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Dissertations / Theses on the topic "Mannich bases"

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Trossini, Gustavo Henrique Goulart. "Antichagásicos potenciais: síntese de bases de Mannich do hidroximetilnitrofural." Universidade de São Paulo, 2004. http://www.teses.usp.br/teses/disponiveis/9/9138/tde-28102010-104123/.

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A doença de Chagas é endemia que afeta grande parte da América Latina. Estima-se que de 18 a 20 milhões de pessoas estejam infectadas pelo parasita causador da doença e que ocorram, aproximadamente, 50.000 mortes relacionadas à doença de Chagas por ano, nos 21 países da área endêmica. O arsenal terapêutico atualmente usado contra a parasitose, constituído por apenas dois fármacos, é insuficiente, considerando-se, também, que ambos não apresentam ação adequada na fase crônica da doença. Em razão de se tratar de parasitose que acomete apenas países em desenvolvimento, o interesse na pesquisa de novos antichagásicos é consideravelmente baixo por parte dos países que se destacam na introdução de novos fármacos na terapêutica. Resta aos países envolvidos a procura por novas alternativas quimioterápicas. Face ao exposto e ante à alta atividade, em testes in vitro contra o Trypanosoma cruzi, do derivado hidroximetilado do nitrofural, intermediário de síntese de bases de Mannich, obtido em trabalhos anteriores, o objetivo do presente projeto foi sintetizar bases de Mannich desse derivado com aminoácidos lisina e arginina e o dipeptídio lisina-arginina resultante. Os compostos foram sintetizados utilizando-se métodos clássicos e alternativos e grupos protetores, normalmente utilizados na síntese de peptídios e outros, tentativamente empregados, como os grupos metílico e etílico. Em adição, experimentos foram efetuados com o objetivo de otimizar a síntese do hidroximetilnitrofural. Os derivados sintetizados foram analisados por IV, RMN 1H e 13C, e alguns deles, também, por espectrometria de massas. Eles serão submetidos a testes in vitro em cultura de células infectadas com T. cruzi tão logo os grupos protetores sejam removidos. Além disso, serão efetuados testes de liberação para estudo da respectiva estabilidade. Dessa forma, esperam-se obter subsídios importantes para estudos mais aprofundados do seu mecanismo de ação e da possível mutagenicidade envolvida.<br>Chaga\'s disease is an endemic disease that aftects most part of Latin Arnerica. About 18 to 20 million people are infected by the parasite and around 50 thousand deaths are related to Chagas\' disease each year, in the 21 countries of endemic areas. The therapeutic armamentarium available against the disease is constituted by only two drugs and is insufficient, considering, also, that the drugs are not efficient in the chronic phase of the disease. As a parasitosis that only occurs in developing countries, the interest in the research for new antichagasic agents is considerably low in countries that are responsible for the introduction of new drugs in the therapeutics. So, the search for new chemotherapeutic alternatives is a task for the involved countries. In view of the situation and taking into account the high activity in in vitro tests against Trypanosoma cruzi showed by nitrofurazone hydroxymethyl derivative, an intermediary of Mannich bases reaction previously synthesized, the objective of this work was to synthesize its Mannich bases. The carriers used were aminoacids lysine and arginine and its dipeptide, lysinearginine. The compounds were synthesized using classic and alternative methods and protecting groups, currently used in peptide synthesis and others temptatively employed, as methyl and ethyl groups. Also, many experiments were performed in order to achieve the optimization of hydroxymethylnitrofurazone synthesis. The derivatives synthesized were analyzed by IR, 1H and 13C NMR, and some also by mass spectrometry. They will be submitted to in vitro tests with cell infected with T. cruzi as soon as the protecting groups are removed. Besides, tests of drug release will be performed to study their stability. We expect to obtain important information toward better comprehension of their mechanism of action and possible mutagenicity involved.

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2

Roche, Maxime. "Etude des 3,4-Dihydro-2H-1, 3-Benzoxzazines : Réactivité - Polymérisation." Besançon, 1989. http://www.theses.fr/1989BESA2039.

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Ce travail consacre a l'etude de la reactivite des 3,4-dihydro-2h-1,3-benzoxazines rend compte de leur aptitude a la polymerisation. Divers composes de ce type, synthetises a partir de phenols, formaldehyde et amines primaires ont ete etudies en spectrometrie de masse, par rmn #1h et #1#3c et par spectroscopie ir. La reaction avec les phenols qui procede par un mecanisme avec ouverture de cycle peut etre consideree comme l'etape d'amorcage d'une polymerisation. Ainsi nous avons etudie, dans un premier temps, la polymerisation de ces benzoxazines amorcee avec des phenols, la mise en evidence d'une reaction secondaire nous a incite a etudier, dans un second temps, la polymerisation par amorcage thermique. Par oxydation anodique en milieu alcoolique basique, nous avons montre qu'il est possible d'obtenir des films isolants. Nous avons etudie leurs modes de formation et de croissance sur des toles de fer, d'acier ou de cuivre. La structure de ces films a ete etudiee en infra-rouge par reflexion multiple, esca et spectroscopie de rmn. Les mecanismes sont abordes a la fois sous l'angle de la polymerisation chimique et de l'electropolymerisation. L'accent est mis sur les perspectives interessantes qu'offre ce nouveau monomere cyclique

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Kandepu, Narayana Murthi. "Mannich bases of chalcones and cyclohexanones as candidate cytotoxic agents." Thesis, National Library of Canada = Bibliothèque nationale du Canada, 1999. http://www.collectionscanada.ca/obj/s4/f2/dsk1/tape7/PQDD_0035/NQ63974.pdf.

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Hermange, Philippe. "Réaction de Mannich vinylogue diastéréosélective entre des sels d’isoquinolinium et des silyloxyfuranesApplication à la synthèse de nouveaux ligands du récepteur GABA-A et à des analogues de l’émétine." Paris 11, 2009. http://www.theses.fr/2009PA112200.

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En partant d’une observation expérimentale révélant la haute diastéréosélectivité obtenue lors de la réaction de Mannich vinylogue entre un sel d’isoquinolinium et un dérivé silyloxyfurane, plusieurs axes de recherche ont été développés au cours de cette thèse. Tout d’abord, une étude méthodologique a permis de généraliser la réaction (rendements et excès diastéréoisomériques supérieurs à 80%). Après la mise au point d’un protocole à trois composantes, la réaction a pu être étendue par exemple à la formation de centres quaternaires ou à l’utilisation de silyloxypyrroles. Le rôle prépondérant de la double liaison 3,4 de l’isoquinoline dans la formation quasi-exclusive du diastéréoisomère R*,R* a ensuite été mis en évidence par la modélisation moléculaire. Le développement d’une version asymétrique à l’aide de copules chirales a conduit à de bons résultats contrairement à ceux obtenus par organocatalyse de thiourées. Cette réaction de Mannich vinylogue diastéréosélective a été appliquée dans deux thématiques de chimie médicinale. Ainsi, certains composés isoquinolino-butyrolactones ont montré des activités intéressantes de modulateurs allostériques positifs du récepteur GABA-A (anxiolytiques potentiels) et une voie d’accès à des composés de 2ème génération substitués en position 1 et 4 de l’isoquinoline a été validée. Enfin, une synthèse courte (6 étapes) pour obtenir des analogues de l’émétine (propriétés anti-tumorales) a été mise au point à partir de l’isoquinoline. Les perspectives de ce travail sont commentées dans la conclusion générale<br>Starting from the high diastereoselectivity observed in the vinylogous Mannich reaction between an isoquinolinium salt and a silyloxyfuran, various research themes were developed during this thesis. First, the scope of the reaction was determined and a methodological study showed that good yields and diastereoselectivities superior to 80% are generally obtained. After optimization of a three component procedure, the reaction was extended to formation of quaternary centers and use of silyloxypyrroles. The importance of the C3-C4 double bond of isoquinoline in favoring the R*,R* configuration was explained by molecular modeling. An asymmetric version of the reaction was also studied and good results were obtained with chiral auxiliaries whereas thiourea-based organocatalysts provided only low enantioselectivities. This diastereoselective vinylogous Mannich reaction was then applied to two medicinal chemistry fields. Thus, several isoquinoline-butyrolactones proved to be potent positive allosteric modulators of the GABA-A receptor (potential anxiolytics). Furthermore, a novel access to a 2nd generation of 1,4-disubstituted compounds was validated. Finally, a short synthesis (6 steps) of emetine analogs having potential anti-tumor properties was developed using our methodology as the key step. The perspectives of this work are presented in the general conclusion

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Ward, Nathan Andrew. "Resurrection of Organophosphorus-Aged Acetylcholinesterase via Mannich Bases Derived from Proline." The Ohio State University, 2019. http://rave.ohiolink.edu/etdc/view?acc_num=osu1565714137331736.

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Ghaib, Amar. "Pharmacomodulation autour du squelette octahydropyrimido[3,4-a]-s-triazines : introduction de restes alkyles de lipophilie croissante." Rouen, 2001. http://www.theses.fr/2001ROUE03NR.

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L'iminodiméthylation de six monoalkyl ou dialkyl 5-aminopyrimidine-l,3-diones par différentes amines primaires fait l'objet de cette étude. La préparation de ces synthons est réalisée à partir de cyanacétates d'éthyles, préalablement alkylés en position 2, qui réagissent avec l'urée, en milieu alcalin. L'alkylation de méthylènes fortement activés qui sont situés entre une fonction nitrile et un groupement ester, en milieu alcalin, conduit à un mélange de dérivés non alkylé, monoalkylé et dialkylé. Il s'est avéré nécessaire d'utiliser les différences de solubilité des sels de ces composés pour les séparer. Dans le but d'éviter ces difficultés, deux autres procédés de synthèse ont été utilisés. L'iminodiméthylation des synthons 5 dialkyl-6-aminopyrimidine-l,3-dione a conduit à 24 octahydropyrimido[3,4-a]-s-triazines, diversement dialkylées qui ont été soumises à un triage pharmacologique automatisé, orienté en particulier dans le domaine antimicrobien. Une série de 23 pyrimido[3,4-a]-s-triazines monoalkylées sur le sommet 9 ont été préparées par iminodiméthylation de 5-monoalkyl-6-aminopyrimidine-1,3-diones. Il a été montré que la structure de ces composés étant triazinique et non pyrimido pyrimidinique comme cela aurait pu être le cas. Ces composés, en dépit d'un bon recouvrement structural avec la Kétansérine, un anti 5-HT2 bien connu, n'ont fait preuve que d'une faible activité dans les conditions de l'essai automatisé<br>Iminodimethylation of 6 monoalkyl and dialkyl 5-aminopyrimidinediones by various primary amines was studied. The synthesis of these synthons was performed from ethyl cyanacetates, previously alkylated in 2 position, which reacted with area in alkaline medium. Alkylation of the strongly activated methylenes, situated between a nitrile and an ester groupe, in alkaline medium, leads to a mixture of unalkylated, monoalkylated and dialkylated derivatives. It was then necessary to use the différences of solubilities of the salts of theses compounds to separated them. In order to avoid these difficulties, two other synthetic pathways were used. Iminodimethylation of these synthons yielded 24 octahydropyrimido[3,4-a]-striazines, variously dialkylated, which were submitted to an automated pharmacological screening, especially in the area of antimicrobial agents. A series of 23 pyrimido[3,4-a]-s-triazines monoalkylated in position 9 were synthetized by iminodimethylation of 5-monoalkyl-6-aminopyrimidine 1,3-diones. It was shown that the structure was triazinic and not pyrimido pyrimidinic as it could have been. These compounds, despite a good overlay with Ketanserin, a well known anti 5-HT2, only showed a weak activity in automated screening

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Al-Sarabi, Alaeddin. "Application de la réaction de Mannich intramoléculaire à la synthèse d'hétérocycles azotés." Clermont-Ferrand 2, 2004. http://www.theses.fr/2004CLF21491.

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Nous avons préparé par une réaction de Mannich intramoléculaire impliquant divers aldéhydes et des bétâ-aminocétones ceto-protégées : L'(-+)-indolizidine 209D en douze étapes à partir du 4-chlorobutanol. L'(-+)-allosédridine en neuf étapes à partir du 5-chloropentanol. Par la même voie, isoindolopipéridines polycycliques ont pu être obtenues en une seule étape. Nous avons pu montrer que cette réaction était applicable en synthèse asymétrique. La synthèse que nous avons effectuée est intéressante comparée aux autres voies de synthèse proposées dans la littérature en termes de simplicité. Elle nécessite des produits de départ commerciaux ou d'un accès facile et le rendement global est satisfaisant. Elle est de plus suffisamment générale pour être appliquée à la préparation d'une grande variété d'alcaloï̈des polycycliques et d'analogues non-naturels

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Vashishtha, Sarvesh Chandra. "Mannich bases and other related compounds designed principally as candidate cytotoxic and anticancer agents." Thesis, National Library of Canada = Bibliothèque nationale du Canada, 1997. http://www.collectionscanada.ca/obj/s4/f2/dsk3/ftp04/nq23886.pdf.

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Thomas, Anne. "Synthèse de dérivés pipéridiniques sur support solide." Clermont-Ferrand 2, 2004. http://www.theses.fr/2004CLF21499.

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Ce travail décrit une nouvelle méthode d'accès à des composés pipéridiniques. Une réaction intramoléculaire de type Mannich, impliquant un aldéhyde et une bétâ-aminocétone protégée, permet la création du cycle pipéridinique. La transposition de cette méthode développée en solution est à l'origine d'un projet délaboration de librairies combinatoires : deux méthodes d'immobilisation de ces squelettes pipéridiniques sur support solide ont été entreprises. La première repose sur l'accrochage de pipéridinones par la fonction cétone via une amination réductrice avec une amine supportée. Un second point de diversité est apporté par un couplage avec un acide. La séquence réactionnelle a été développée en solution, puis adaptée à la phase solide. La variation des acides et des amines primaires, ainsi que la modification des substituants du squelette pipéridinique, ont été etudiées. Vingt pipéridines 1,4- ou 1,2,4- substituées ont ainsi été préparées en 5 étapes avec des rendements compris entre 7 et 99%, dont la moitié est supérieur à 65%. Pour la seconde approche, l'application de la méthode de formation du cycle pipéridinique permet d'obtenir des pipéridinones protégées possédant une chaine latérale en alpha de l'atome d'azote. L'aldéhyde ou l'amine peut être vecteur de cette chaîne. L'étude des transformations fonctionnelles n'a pas abouti à l'obtention des scaffolds susceptibles d'être accrochés sur support solide via cette chaîne latérale. La synthèse des précurseurs a donc été transposée sur phase solide. La première formation d'une pipérinide supportée a été observée lors de la cyclisation de l'aldéhyde supportée avec une amine en solution. La cyclisation de l'amine supportée avec des aldéhydes commerciaux facilitera l'introduction d'un point de diversité et sera ainsi plus appropriée à une application en chimie combinatoire

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TEDLAOUTI, FATIHA. "Pharmacologie antimalarique et trypanocide de derives thiopheniques, de bases de mannich et de saponosides d'hedera helix l. , calendula arvensis l. Et de sapendus mukurosi l." Aix-Marseille 2, 1991. http://www.theses.fr/1991AIX22957.

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Books on the topic "Mannich bases"

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Luigi, Angiolini, ed. Mannich bases: Chemistry and uses. CRC Press, 1994.

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Challiner, John Francis. Photochemistry of imide mannich bases. The Polytechnic, Wolverhampton, Department of Physical Sciences, 1985.

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127-mannin no jikken. Okinawa Taimususha, 1997.

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Irving, Washington. The Sketch-Book of Geoffrey Crayon, Gent. Edited by Susan Manning. Oxford University Press, 2009. http://dx.doi.org/10.1093/owc/9780199555819.001.0001.

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The Sketch-Book (1820–1) looks simultaneously towards audiences on both sides of the Atlantic, as Irving explores the uneasy relationship of an American writer to English literary traditions. He sketches a series of encounters with the cultural shrines of the parent nation, and in two brilliant experiments with tales transplanted from Europe creates the first classic American short stories, ‘Rip Van Winkle’ and ‘The Legend of the Sleepy Hollow’. The result was not only a hugely successful travel book; it exerted a strong formative influence on American writers from Nathaniel Hawthorne and Edgar Allan Poe to Henry James, and is well worth rediscovery in its own right today. Based on Irving’s final revision of his most popular work, this new edition includes comprehensive explanatory notes of The Sketch-Book’s sources for the modern reader. In her introduction, Susan Manning suggests that the author forged a new idiom, the ‘Literary Picturesque’, to accommodate and turn to advantage his dilemma of dual literary allegiances.

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Book chapters on the topic "Mannich bases"

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Seeni Mubarak, M., R. Kathirvel, M. Sathyanarayanan, and S. Mohamed Rabeek. "Some Novel Mannich Bases-Synthesis, Crystal Structure, Docking Studies, Anti-microbial Activity, and Cytotoxicity." In Springer Proceedings in Physics. Springer International Publishing, 2017. http://dx.doi.org/10.1007/978-3-319-44890-9_56.

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Koll, Aleksander, and Peter Wolschann. "Mannich Bases as Model Compounds for Intramolecular Hydrogen Bonding II [1] Structure and Properties in Solution." In Hydrogen Bond Research. Springer Vienna, 1999. http://dx.doi.org/10.1007/978-3-7091-6419-8_3.

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Colacio, Enrique. "Mannich Base Ligands as Versatile Platforms for SMMs." In Topics in Organometallic Chemistry. Springer International Publishing, 2018. http://dx.doi.org/10.1007/3418_2018_4.

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Pardasani, R. T., and P. Pardasani. "Magnetic properties of copper(II) complex with Mannich base, N-(morpholinobenzyl)-benzamide." In Magnetic Properties of Paramagnetic Compounds, Magnetic Susceptibility Data, Volume 4. Springer Berlin Heidelberg, 2021. http://dx.doi.org/10.1007/978-3-662-62474-6_107.

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Petty, Stephen D., and Lyn Hester. "“Manning Up for Men’s Health”: Sports Radio and the INTEGRIS Men’s Health University, Oklahoma, USA." In Sports-Based Health Interventions. Springer New York, 2015. http://dx.doi.org/10.1007/978-1-4614-5996-5_24.

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Pietraszkiewicz, Oksana, Małgorzata Koźbiał, and Marek Pietraszkiewicz. "Transport Studies of Inorganic and Organic Cations Across Liqued Membranes Containing Mannich-Base Calix[4]Resorcinarenes." In Molecular Recognition and Inclusion. Springer Netherlands, 1998. http://dx.doi.org/10.1007/978-94-011-5288-4_83.

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Al-Mamari, Mahmood M., Sameh A. Kantoush, and Tetsuya Sumi. "Innovative Monitoring Techniques for Wadi Flash Flood by Using Image-Based Analysis." In Natural Disaster Science and Mitigation Engineering: DPRI reports. Springer Singapore, 2021. http://dx.doi.org/10.1007/978-981-16-2904-4_9.

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AbstractFlash floods in wadi systems are a very important environmental issue, and their monitoring is necessary for many applications, including water resource management, irrigation and flood control. However, monitoring networks are very rare and lack spatial distribution features. In this study, image-based techniques were used to quantify and monitor flash floods in wadi channels by using two different methods. In the first section, we employed photogrammetry processing technique to quantify post-peak flood discharges by using a drone survey to build a digital elevation model (DEM) with a high resolution and calibrated and validated the model with a field survey (levelling measurements). This technique used drone-collected images to construct a DEM for extracting a cross-sectional profile and elevation points to calculate the peak discharge using the slope-area method with the Manning equation. In the second section, we combined the previous technique with the large-scale particle image velocimetry (LSPIV) technique to measure flash flood discharge by installing a fixed camera on a road bridge crossing a wadi channel and using a digitally extracted cross section from the DEM in the analysis. The results of those techniques show a high efficiency that is equivalent to that of conventional methods.

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Black, D. StC. "Substitution Reactions of Mannich Bases." In Fully Unsaturated Small-Ring Heterocycles and Monocyclic Five-Membered Hetarenes with One Heteroatom. Georg Thieme Verlag KG, 2001. http://dx.doi.org/10.1055/sos-sd-009-00657.

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P, Sounthari, and Sivakumar P.R. "Schiff Bases - Interesting Range of Applications in Various Fields of Science." In Synthesis and Characterization of Some Novel Mannich Base Compounds. IOR INTERNATIONAL PRESS, 2019. http://dx.doi.org/10.34256/ioriip1982.

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Hof, K., K. M. Lippert, and P. R. Schreiner. "Mannich Reaction." In Brønsted Base and Acid Catalysts, and Additional Topics. Georg Thieme Verlag KG, 2012. http://dx.doi.org/10.1055/sos-sd-205-00228.

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Conference papers on the topic "Mannich bases"

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Funar-Timofei, Simona, Ana Borota, Alina Bora, Sorin Avram, and Daniela Ionescu. "QSAR MODELING ON FUNGICIDAL ACTIVITY OF MANNICH BASES." In The 19th International Electronic Conference on Synthetic Organic Chemistry. MDPI, 2015. http://dx.doi.org/10.3390/ecsoc-19-e005.

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Verigina, Anastasiia Alexseevna, Tatiana Sergeevna Stepanova, and Pavel Iosifovich Pinko. "PREPARATION OF ALKYLTHIOMETHYLATED DERIVATIVES OF 2,4-DI-TERT-BUTYLPHENOL AND PRELIMINARY ASSESSMENT OF THEIR ANTIOXIDANT ACTIVITY." In IX Международная научно-практическая конференция "Инновационные аспекты развития науки и техники". KDU, Moscow, 2021. http://dx.doi.org/10.31453/kdu.ru.978-5-7913-1190-0-2021-6-14.

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This article discusses a method for the preparation of alkylthiomethyl derivatives of 2,4-di-tert-butylphenol through the interaction of the obtained Mannich bases with aliphatic thiols of various structures, as well as a preliminary assessment of the antioxidant activity by anodic voltammetry.

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Allochio Filho, J. F., L. L. Roldi, R. Fiorot, et al. "Synthesis and in vitro antifungal activity of new Mannich bases derived from 2-hydroxy-1,4-naphthoquinone (Lawsone)." In 15th Brazilian Meeting on Organic Synthesis. Editora Edgard Blücher, 2013. http://dx.doi.org/10.5151/chempro-15bmos-bmos2013_2013916122532.

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He, Meng, Haoyuan Kang, Juanbo Liu, Sheng Chen, Xueru Gong, and Li Sun. "Development of Inhibitor for Corrosion Protection of Condensate Stripping Process in Industrial Coal Gasification Unit." In ASME 2021 Pressure Vessels & Piping Conference. American Society of Mechanical Engineers, 2021. http://dx.doi.org/10.1115/pvp2021-61869.

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Abstract The condensate involving HS-, CO32−, Cl− and NH4+ usually causes severe corrosion of 20 steel in condensate stripping process of industrial coal gasification unit. The corrosion can easily lead to failure of pipe fittings and vessels, and result in economic losses and personal injury. To protect industrial coal gasification unit against corrosion, five inhibitors including imidazoline, imidazoline amide, mannich base quaternary ammonium salt, pyridine, and sodium molybdate are investigated with experiment of linear polarization curve, polarization curve, electrochemical impedance spectroscopy (EIS). The gas-liquid two phase experimental conditions mixed with suitable concentration of H2S, CO2 and NH4Cl are as close to the industrial alkalescent corrosion environment as possible. The experiment results indicate that two inhibitors of the mannich base quaternary ammonium salt and the pyridine have better effects on corrosion protection than others at the same injection concentration of 100ppm. A new compound inhibitor is developed based on the mannich base quaternary ammonium salt and the pyridine in terms of above results. The new compound inhibitor’s efficiency further reaches to 95.5%, suggesting that the new compound inhibition has better effect on corrosion protection than either of two single inhibitors above.

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LaGrange, Elgonda, Brett Bollinger, and Ali Elnaamani. "Digitally Transforming Offshore Production: Making Low-Manned Brownfield Installations a Reality." In Offshore Technology Conference. OTC, 2021. http://dx.doi.org/10.4043/30996-ms.

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Abstract This paper outlines an approach for de-manning brownfield offshore production installations. It discusses how the latest advancements in rotating equipment, electrical & automation systems, and digitalization can be applied to reduce operating costs, lower breakeven prices, and extend the lifetime of existing/aging fields. The approach is value-rather than technology-driven and focuses on prioritizing investments based on return on investment (ROI) to enable low-manned operations as a stepping-stone towards unmanned installations. The paper discusses key facets of a holistic de-manning strategy, including: Remotely controlled production operations Predictive analytics to reduce unplanned downtime and extend mean time between overhauls (MTBO) Automated inspections Remote collaboration Unified data management Change management The concepts presented in the paper are derived from the authors’ company's work implementing digital solutions for customers in both onshore and offshore oil and gas, and power generation industries. It also draws on the results of an in-depth onshore field de-manning study that was conducted for a major Middle East national oil company (NOC).

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Rodríguez, Laura, Elena Viqueira, Oscar Souto, and Antonio Sousa-Pedrares. "Synthesis and characterization of new Mannich base ligand. Structure of N, N-bis-(4,5-dimethyl-2-hydroxybenzyl)-N(2-pyridylmethyl)amine." In The 10th International Electronic Conference on Synthetic Organic Chemistry. MDPI, 2006. http://dx.doi.org/10.3390/ecsoc-10-01414.

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Chaithra, N., P. C. Shruthi, V. Rashmi, V. Akhil, and S. S. M. Saqquaf. "An IoT Based Railway Security System for Automated Manning at Level Crossings." In 2018 3rd IEEE International Conference on Recent Trends in Electronics, Information & Communication Technology (RTEICT). IEEE, 2018. http://dx.doi.org/10.1109/rteict42901.2018.9012435.

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ZHOU, WENJUN. "HOW TO IMPROVE THE ECONOMIC BENEFITS OF HARBOR AS A SHIP." In 2021 INTERNATIONAL CONFERENCE ON ADVANCED EDUCATION AND INFORMATION MANAGEMENT (AEIM 2021). Destech Publications, Inc., 2021. http://dx.doi.org/10.12783/dtssehs/aeim2021/35968.

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Abstract. Starting from the operation mode of port-based ships, through analyzing the problems existing in the economic development of port-based ships at this stage, suggestions for improvement are proposed based on the three aspects of platform, manning and crew work and rest, thereby significantly improving the economy of port-operating ships benefit.

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Nguyen, Van Tri, Didier Georges, and Gildas Besancon. "Adjoint-method-based estimation of Manning roughness coefficient in an overland flow model." In 2015 American Control Conference (ACC). IEEE, 2015. http://dx.doi.org/10.1109/acc.2015.7171023.

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MacKenzie, Adam, J. O. Miller, and Raymond Hill. "An exploration of the effects of maintenance manning on Combat Mission Readiness utilizing agent based modeling." In 2010 Winter Simulation Conference - (WSC 2010). IEEE, 2010. http://dx.doi.org/10.1109/wsc.2010.5679053.

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Reports on the topic "Mannich bases"

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Kaplan, Jonathan D. A Concept for Developing a Data Base to Aid in System Manning Prediction. Defense Technical Information Center, 1985. http://dx.doi.org/10.21236/ada161662.

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