Relevant bibliographies by topics / Mannich bases of phthalimides

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Academic literature on the topic 'Mannich bases of phthalimides'

Author: Grafiati
Published: 5 June 2025
Last updated: 1 August 2025

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Journal articles on the topic "Mannich bases of phthalimides"

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SHEELA, JOSHI, MATKAR SATISH, KHOSLA NAVITA, and BHANDARI VINITA. "Synthesis and Biological Screening of N4-Phthalimidomethyl Sulphonamides." Journal of Indian Chemical Society Vol. 74, Feb 1997 (1997): 156–57. https://doi.org/10.5281/zenodo.5876043.

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Institute of Chemical Sciences, Devi Ahilya Vishwavidyalaya, lndore-452 001 <em>Manuscript received 16 March 1995, revised 4 August 1995. accepted 14 August 1995</em> Synthesis and Biological Screening of N4-Phthalimidomethyl Sulphonamides.
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2

Yunus, Uzma, Moazzam H. Bhatti, Naima Rahman, Nosheen Mussarat, Shazia Asghar, and Bilal Masood. "Synthesis, Characterization, and Biological Activity of Novel Schiff and Mannich Bases of 4-Amino-3-(N-phthalimidomethyl)-1,2,4-triazole-5-thione." Journal of Chemistry 2013 (2013): 1–8. http://dx.doi.org/10.1155/2013/638520.

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The present work describes the syntheses and antimicrobial activity studies of a series of novel Schiff bases (4a–4i) and their Mannich bases (5a–5h) starting from 4-amino-3-(N-phthalimido-methyl)-1,2,4-triazole-5-thione (3). All the synthesized compounds were characterized by IR,1H-NMR,13C-NMR, and MS. All the synthesized compounds were screened for four Gram-negative strains, one Gram-positive strain of bacteria, and one diploid fungal strain. In general the antimicrobial activity increased remarkably on the introduction of azomethine functionality in parent triazole (3). The antimicrobial a
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Girish, Kumar Sinha, Pandey Bibhishan, and Singh Nityanand. "Synthesis of some nitrogen mustards." Journal of Indian Chemical Society Vol. 76, Feb 1999 (1999): 110–11. https://doi.org/10.5281/zenodo.5852539.

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Department of Chemistry, Science College, Patna-800 005, India <em>Manuscript received 23 August 1990 revised 15 June 1998, accepted 19 August 1998</em> Several Mannich base nitrogen mustards have been synthesised by the condensation of 3-substitutcd-phthalimides and 4-suhstitutedphthalimides with <em>N-</em>bis(2-chloroethyl)amine in ethanol-formalin
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Deo, Prem Shankar, Rhambus Rawat, and Bhushan Shakya. "Synthesis, Characterization and Antimicrobial Evaluation of Mannich Bases of 4-(Furan-2-yl-methyleneamino)-3-(2-hydroxyphenyl)-1H-1,2,4-triazole-5-thione." Journal of Nepal Chemical Society 42, no. 1 (2021): 6–15. http://dx.doi.org/10.3126/jncs.v42i1.35322.

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Triazole nucleus has drawn much attention since the last decade because of its various potent biological activities. The pharmacological application of triazoles has been widely recognized and well documented. Schiff and Mannich bases are both considered as bioactive compounds, however, there are not much of documentation about the Mannich bases as their study has begun lately. The main aim of this study was to synthesize new Mannich bases from Schiff base bearing 1,2,4-triazole nucleus to access their antimicrobial activities. The newly synthesized compounds 1,2,4-triazole-5-thione, Schiff ba
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Babbar, Ritchu, Swikriti ., Sandeep Arora, and Thakur G. Singh. "Therapeutic Potential of Schiff and Mannich Bases of 2-Substituted Benzimidazole Analogues." INTERNATIONAL JOURNAL OF DRUG DELIVERY TECHNOLOGY 13, no. 02 (2022): 753–58. http://dx.doi.org/10.25258/ijddt.13.2.44.

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Heterocyclic scaffolds reveal extensive biological profiles, and several drugs were employed therapeutically which possess heterocyclic framework. Likewise, 2-substituted benzimidazoles play a significant role in novel drug development. In addition, Mannich and schiff base derivatives of benzimidazole acknowledged them as favorable anti-inflammatory, antimicrobial, anticancer, anthelmintic, antiviral scaffolds. Schiff bases in innumerable organic reactions show affirmative catalytic activity. The current scenario also emphasizes the spectacular activity displayed by schiff bases in the biochem
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Raju, Senthil Kumar, Priyadharshini Vengadhajalaphathy, Revathy Sundaram, Sangeetha Periyasamy, Thatchayani Chinnaraj, and Praveen Sekar. "Recent advances in biological applications of mannich bases — An overview." International Journal of Pharmaceutical Chemistry and Analysis 10, no. 1 (2023): 15–27. http://dx.doi.org/10.18231/j.ijpca.2023.004.

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Mannich bases are beta-amino ketone-carrying compounds that are the end products of the Mannich reaction. The Mannich reaction is essential in the synthesis of nitrogen-containing compounds. The Mannich reaction, a nucleophilic addition reaction that forms carbon-carbon bonds, is employed in the synthesis of numerous natural products, drugs and other compounds. There are several aminoalkyl chain bearing Mannich bases with high curative value, such as fluoxetine, atropine, ethacrynic acid, trihexyphenidyl, and many others. According to the literature, Mannich bases are highly reactive and have
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Senthil Kumar Raju, Archana Settu, Archana Thiyagarajan, and Divya Rama. "Synthetic applications of biologically important Mannich bases: An updated review." Open Access Research Journal of Biology and Pharmacy 7, no. 2 (2023): 001–15. http://dx.doi.org/10.53022/oarjbp.2023.7.2.0015.

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Mannich bases are the beta-amino ketones carrying compounds. Mannich reaction is a nucleophilic addition reaction (nucleophiles such as halogen ions (I-, Br-, Cl- ), the hydroxide ion (OH- ), cyanide ion (CN-), ammonia and water, which involves the condensation of three components, viz., ammonia or a primary amine or a secondary amine or with amides, a non-enolizable aldehyde, usually formaldehyde and a compound containing an active hydrogen atom. These three compounds condense with the concomitant release of the water molecule to produce a new base known as a mannich base, in which the active
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Bala, Suman, Neha Sharma, Anu Kajal, Sunil Kamboj, and Vipin Saini. "Mannich Bases: An Important Pharmacophore in Present Scenario." International Journal of Medicinal Chemistry 2014 (November 12, 2014): 1–15. http://dx.doi.org/10.1155/2014/191072.

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Mannich bases are the end products of Mannich reaction and are known as beta-amino ketone carrying compounds. Mannich reaction is a carbon-carbon bond forming nucleophilic addition reaction and is a key step in synthesis of a wide variety of natural products, pharmaceuticals, and so forth. Mannich reaction is important for the construction of nitrogen containing compounds. There is a number of aminoalkyl chain bearing Mannich bases like fluoxetine, atropine, ethacrynic acid, trihexyphenidyl, and so forth with high curative value. The literature studies enlighten the fact that Mannich bases are
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Dimmock, J. R., and P. Kumar. "Anticancer and Cytotoxic Properties of Mannich Bases." Current Medicinal Chemistry 4, no. 1 (1997): 1–22. http://dx.doi.org/10.2174/0929867304666220309194437.

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This review outlines the chemistry and anticancer and cytotoxic properties of certain Mannich bases. It is divided into four parts. The first section summarizes briefly various investigations undertaken by other researchers of the chemical and pharmacological properties of a number of Mannich bases against neoplasms. The remaining portions of this review are summaries of work undertaken in this laboratory. The second part presents the following aspects of the anticancer properties of various Mannich bases namely differences in antileukemic activity between certain conjugated styryl ketones and
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Comanita, Eugenia, Gheorghe Roman, Irina Popovici, and Bogdan Comanita. "Synthesis and reactivity of some mannich bases. VIII. Studies on several mannich bases derived from ortho-hidroxyacetophenones and their conversion into oximino derivatives." Journal of the Serbian Chemical Society 66, no. 1 (2001): 9–16. http://dx.doi.org/10.2298/jsc0101009c.

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The synthesis of several Mannich bases resulting from the reaction of 2-hydroxy-4-methylacetophenone with paraformaldehyde and secondary amines is reported. Another series of products was obtained from N,N-dimethyl substituted Mannich bases by replacing the amino group with pyrrolidine. Most of the Mannich bases were transformed into oximes by treatment with hydroxylamine hydrochloride in 10% NaOH.
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Dissertations / Theses on the topic "Mannich bases of phthalimides"

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Trossini, Gustavo Henrique Goulart. "Antichagásicos potenciais: síntese de bases de Mannich do hidroximetilnitrofural." Universidade de São Paulo, 2004. http://www.teses.usp.br/teses/disponiveis/9/9138/tde-28102010-104123/.

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A doença de Chagas é endemia que afeta grande parte da América Latina. Estima-se que de 18 a 20 milhões de pessoas estejam infectadas pelo parasita causador da doença e que ocorram, aproximadamente, 50.000 mortes relacionadas à doença de Chagas por ano, nos 21 países da área endêmica. O arsenal terapêutico atualmente usado contra a parasitose, constituído por apenas dois fármacos, é insuficiente, considerando-se, também, que ambos não apresentam ação adequada na fase crônica da doença. Em razão de se tratar de parasitose que acomete apenas países em desenvolvimento, o interesse na pesquisa de
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Kandepu, Narayana Murthi. "Mannich bases of chalcones and cyclohexanones as candidate cytotoxic agents." Thesis, National Library of Canada = Bibliothèque nationale du Canada, 1999. http://www.collectionscanada.ca/obj/s4/f2/dsk1/tape7/PQDD_0035/NQ63974.pdf.

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Ward, Nathan Andrew. "Resurrection of Organophosphorus-Aged Acetylcholinesterase via Mannich Bases Derived from Proline." The Ohio State University, 2019. http://rave.ohiolink.edu/etdc/view?acc_num=osu1565714137331736.

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Roche, Maxime. "Etude des 3,4-Dihydro-2H-1, 3-Benzoxzazines : Réactivité - Polymérisation." Besançon, 1989. http://www.theses.fr/1989BESA2039.

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Ce travail consacre a l'etude de la reactivite des 3,4-dihydro-2h-1,3-benzoxazines rend compte de leur aptitude a la polymerisation. Divers composes de ce type, synthetises a partir de phenols, formaldehyde et amines primaires ont ete etudies en spectrometrie de masse, par rmn #1h et #1#3c et par spectroscopie ir. La reaction avec les phenols qui procede par un mecanisme avec ouverture de cycle peut etre consideree comme l'etape d'amorcage d'une polymerisation. Ainsi nous avons etudie, dans un premier temps, la polymerisation de ces benzoxazines amorcee avec des phenols, la mise en evidence d'
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Hermange, Philippe. "Réaction de Mannich vinylogue diastéréosélective entre des sels d’isoquinolinium et des silyloxyfuranesApplication à la synthèse de nouveaux ligands du récepteur GABA-A et à des analogues de l’émétine." Paris 11, 2009. http://www.theses.fr/2009PA112200.

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En partant d’une observation expérimentale révélant la haute diastéréosélectivité obtenue lors de la réaction de Mannich vinylogue entre un sel d’isoquinolinium et un dérivé silyloxyfurane, plusieurs axes de recherche ont été développés au cours de cette thèse. Tout d’abord, une étude méthodologique a permis de généraliser la réaction (rendements et excès diastéréoisomériques supérieurs à 80%). Après la mise au point d’un protocole à trois composantes, la réaction a pu être étendue par exemple à la formation de centres quaternaires ou à l’utilisation de silyloxypyrroles. Le rôle prépondérant d
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Vashishtha, Sarvesh Chandra. "Mannich bases and other related compounds designed principally as candidate cytotoxic and anticancer agents." Thesis, National Library of Canada = Bibliothèque nationale du Canada, 1997. http://www.collectionscanada.ca/obj/s4/f2/dsk3/ftp04/nq23886.pdf.

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Ghaib, Amar. "Pharmacomodulation autour du squelette octahydropyrimido[3,4-a]-s-triazines : introduction de restes alkyles de lipophilie croissante." Rouen, 2001. http://www.theses.fr/2001ROUE03NR.

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L'iminodiméthylation de six monoalkyl ou dialkyl 5-aminopyrimidine-l,3-diones par différentes amines primaires fait l'objet de cette étude. La préparation de ces synthons est réalisée à partir de cyanacétates d'éthyles, préalablement alkylés en position 2, qui réagissent avec l'urée, en milieu alcalin. L'alkylation de méthylènes fortement activés qui sont situés entre une fonction nitrile et un groupement ester, en milieu alcalin, conduit à un mélange de dérivés non alkylé, monoalkylé et dialkylé. Il s'est avéré nécessaire d'utiliser les différences de solubilité des sels de ces composés pour
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Al-Sarabi, Alaeddin. "Application de la réaction de Mannich intramoléculaire à la synthèse d'hétérocycles azotés." Clermont-Ferrand 2, 2004. http://www.theses.fr/2004CLF21491.

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Nous avons préparé par une réaction de Mannich intramoléculaire impliquant divers aldéhydes et des bétâ-aminocétones ceto-protégées : L'(-+)-indolizidine 209D en douze étapes à partir du 4-chlorobutanol. L'(-+)-allosédridine en neuf étapes à partir du 5-chloropentanol. Par la même voie, isoindolopipéridines polycycliques ont pu être obtenues en une seule étape. Nous avons pu montrer que cette réaction était applicable en synthèse asymétrique. La synthèse que nous avons effectuée est intéressante comparée aux autres voies de synthèse proposées dans la littérature en termes de simplicité. Elle n
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Slacke, Mark Philip. "The potential use of lignin Mannich bases as flocculating agent in white water clarification using dissolved air flotation." Thesis, National Library of Canada = Bibliothèque nationale du Canada, 1998. http://www.collectionscanada.ca/obj/s4/f2/dsk2/tape17/PQDD_0005/MQ33754.pdf.

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Thomas, Anne. "Synthèse de dérivés pipéridiniques sur support solide." Clermont-Ferrand 2, 2004. http://www.theses.fr/2004CLF21499.

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Ce travail décrit une nouvelle méthode d'accès à des composés pipéridiniques. Une réaction intramoléculaire de type Mannich, impliquant un aldéhyde et une bétâ-aminocétone protégée, permet la création du cycle pipéridinique. La transposition de cette méthode développée en solution est à l'origine d'un projet délaboration de librairies combinatoires : deux méthodes d'immobilisation de ces squelettes pipéridiniques sur support solide ont été entreprises. La première repose sur l'accrochage de pipéridinones par la fonction cétone via une amination réductrice avec une amine supportée. Un second po
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Books on the topic "Mannich bases of phthalimides"

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Challiner, John Francis. Photochemistry of imide mannich bases. The Polytechnic, Wolverhampton, Department of Physical Sciences, 1985.

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Luigi, Angiolini, ed. Mannich bases: Chemistry and uses. CRC Press, 1994.

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Book chapters on the topic "Mannich bases of phthalimides"

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Seeni Mubarak, M., R. Kathirvel, M. Sathyanarayanan, and S. Mohamed Rabeek. "Some Novel Mannich Bases-Synthesis, Crystal Structure, Docking Studies, Anti-microbial Activity, and Cytotoxicity." In Springer Proceedings in Physics. Springer International Publishing, 2017. http://dx.doi.org/10.1007/978-3-319-44890-9_56.

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Koll, Aleksander, and Peter Wolschann. "Mannich Bases as Model Compounds for Intramolecular Hydrogen Bonding II [1] Structure and Properties in Solution." In Hydrogen Bond Research. Springer Vienna, 1999. http://dx.doi.org/10.1007/978-3-7091-6419-8_3.

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Black, D. StC. "Substitution Reactions of Mannich Bases." In Fully Unsaturated Small-Ring Heterocycles and Monocyclic Five-Membered Hetarenes with One Heteroatom. Georg Thieme Verlag KG, 2001. http://dx.doi.org/10.1055/sos-sd-009-00657.

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P, Sounthari, and Sivakumar P.R. "Schiff Bases - Interesting Range of Applications in Various Fields of Science." In Synthesis and Characterization of Some Novel Mannich Base Compounds. IOR INTERNATIONAL PRESS, 2019. http://dx.doi.org/10.34256/ioriip1982.

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Pishawikar, Sachin A., Harinath N. More, Ravindra B. Kumbhar, and Sujeet V. Salokhe. "Mannich Bases of Thiosemicarbazide: The Mutual Prodrugs as Anti-Infective Agents." In Novel Aspects on Pharmaceutical Research Vol. 8. B P International (a part of SCIENCEDOMAIN International), 2023. http://dx.doi.org/10.9734/bpi/napr/v8/6155a.

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Conference papers on the topic "Mannich bases of phthalimides"

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Farj, Alaa Sarhan, and Khalida F. Al-Azawi. "Synthesis, characterization and antimicrobial activity of novel Mannich bases." In TECHNOLOGIES AND MATERIALS FOR RENEWABLE ENERGY, ENVIRONMENT AND SUSTAINABILITY: TMREES21Gr. AIP Publishing, 2022. http://dx.doi.org/10.1063/5.0092314.

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Funar-Timofei, Simona, Ana Borota, Alina Bora, Sorin Avram, and Daniela Ionescu. "QSAR MODELING ON FUNGICIDAL ACTIVITY OF MANNICH BASES." In The 19th International Electronic Conference on Synthetic Organic Chemistry. MDPI, 2015. http://dx.doi.org/10.3390/ecsoc-19-e005.

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Verigina, Anastasiia Alexseevna, Tatiana Sergeevna Stepanova, and Pavel Iosifovich Pinko. "PREPARATION OF ALKYLTHIOMETHYLATED DERIVATIVES OF 2,4-DI-TERT-BUTYLPHENOL AND PRELIMINARY ASSESSMENT OF THEIR ANTIOXIDANT ACTIVITY." In IX Международная научно-практическая конференция "Инновационные аспекты развития науки и техники". KDU, Moscow, 2021. http://dx.doi.org/10.31453/kdu.ru.978-5-7913-1190-0-2021-6-14.

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This article discusses a method for the preparation of alkylthiomethyl derivatives of 2,4-di-tert-butylphenol through the interaction of the obtained Mannich bases with aliphatic thiols of various structures, as well as a preliminary assessment of the antioxidant activity by anodic voltammetry.
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Allochio Filho, J. F., L. L. Roldi, R. Fiorot, et al. "Synthesis and in vitro antifungal activity of new Mannich bases derived from 2-hydroxy-1,4-naphthoquinone (Lawsone)." In 15th Brazilian Meeting on Organic Synthesis. Editora Edgard Blücher, 2013. http://dx.doi.org/10.5151/chempro-15bmos-bmos2013_2013916122532.

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