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Relevant bibliographies by topics / Manzamine A

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Academic literature on the topic 'Manzamine A'

Author: Grafiati

Published: 4 June 2021

Last updated: 1 February 2022

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Journal articles on the topic "Manzamine A"

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Palem, Jayavardhana R., Mudit Mudit, Shao-chung V. Hsia, and Khalid A. El Sayed. "Discovery and preliminary structure-activity relationship of the marine natural product manzamines as herpes simplex virus type-1 inhibitors." Zeitschrift für Naturforschung C 72, no. 1-2 (2017): 49–54. http://dx.doi.org/10.1515/znc-2016-0080.

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Abstract Herpes simplex virus type-1 (HSV-1) is a member of alpha-herpesviridae family and is known to cause contagious human infections. The marine habitat is a rich source of structurally unique bioactive secondary metabolites. A small library of marine natural product classes 1–10 has been screened to discover a new hit entity active against HSV-1. Manzamine A showed potent activity against HSV-1 via targeting the viral gene ICP0. Manzamine A is a β-carboline alkaloid isolated from the Indo-Pacific sponge Acanthostrongylophora species. Currently, acyclovir is the drug of choice for HSV-1 in

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Ang, Kenny K. H., Michael J. Holmes, Tatsuo Higa, Mark T. Hamann, and Ursula A. K. Kara. "In Vivo Antimalarial Activity of the Beta-Carboline Alkaloid Manzamine A." Antimicrobial Agents and Chemotherapy 44, no. 6 (2000): 1645–49. http://dx.doi.org/10.1128/aac.44.6.1645-1649.2000.

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ABSTRACT Manzamine A, a β-carboline alkaloid present in several marine sponge species, inhibits the growth of the rodent malaria parasitePlasmodium berghei in vivo. More than 90% of the asexual erythrocytic stages of P. berghei were inhibited after a single intraperitoneal injection of manzamine A into infected mice. A remarkable aspect of manzamine A treatment is its ability to prolong the survival of highly parasitemic mice, with 40% recovery 60 days after a single injection. Oral administration of an oil suspension of manzamine A also produced significant reductions in parasitemia. The plas

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Lin, Li-Chun, Tzu-Ting Kuo, Hsin-Yi Chang, Wen-Shan Liu, Shih-Min Hsia, and Tsui-Chin Huang. "Manzamine A Exerts Anticancer Activity against Human Colorectal Cancer Cells." Marine Drugs 16, no. 8 (2018): 252. http://dx.doi.org/10.3390/md16080252.

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Marine sponges are known to produce numerous bioactive secondary metabolites as defense strategies to avoid predation. Manzamine A is a sponge-derived β-carboline-fused pentacyclic alkaloid with various bioactivities, including recently reported anticancer activity on pancreatic cancer. However, its cytotoxicity and mode of action against other tumors remain unclear. In this study, we exhibit that manzamine A reduced cell proliferation in several colorectal cancer (CRC) cell lines. To further investigate the manzamine A triggered molecular regulation, we analyzed the gene expression with micro

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Alam, Gemini, Puji Astuti, Subagus Wahyuono, Dinar Sari, and Mark T. Hamman. "STRUCTURE ELUCIDATION OF BIOACTIVE ALKALOID COMPOUNDS ISOLATED FROM SPONGE Petrosia sp COLLECTED FROM BUNAKEN BAY MENADO." Indonesian Journal of Chemistry 5, no. 2 (2010): 177–81. http://dx.doi.org/10.22146/ijc.21828.

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Two alkaloid compounds have been isolated from sponge Petrosia sp collected from Bunaken Bay Menado. These compounds have been found to inhibit several human cancer cell proliferation in vitro. Structure elucidation is needed to further characterize these bioactive compounds. The structure is determined by analyzing Ultra Violet (UV), Infra Red (IR), Mass Spectra (MS) and Nuclear Magnetic Resonance (NMR) spectra. Based on spectroscopic data, Thin Layer Chromatography (TLC) co-chromatograph with authentic samples and comparison with reported data the two compounds were identified as Manzamine A

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MaGee, David I., and Ellen J. Beck. "The use of the RambergBäcklund rearrangement for the formation of aza-macrocycles: a total synthesis of manzamine C." Canadian Journal of Chemistry 78, no. 8 (2000): 1060–66. http://dx.doi.org/10.1139/v00-103.

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A total synthesis of the marine alkaloid manzamine C has been accomplished. A Ramberg-Bäcklund reaction was used as a key step to construct the required azacycloundecene ring.Key words: alkaloid, macrocycle, RambergBäcklund, manzamine C.

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Mayer, Alejandro M. S., Mary L. Hall, Joseph Lach та ін. "RSK1 vs. RSK2 Inhibitory Activity of the Marine β-Carboline Alkaloid Manzamine A: A Biochemical, Cervical Cancer Protein Expression, and Computational Study". Marine Drugs 19, № 9 (2021): 506. http://dx.doi.org/10.3390/md19090506.

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Manzamines are complex polycyclic marine-derived β-carboline alkaloids with reported anticancer, immunostimulatory, anti-inflammatory, antibacterial, antiviral, antimalarial, neuritogenic, hyperlipidemia, and atherosclerosis suppression bioactivities, putatively associated with inhibition of glycogen synthase kinase-3, cyclin-dependent kinase 5, SIX1, and vacuolar ATPases. We hypothesized that additional, yet undiscovered molecular targets might be associated with Manzamine A’s (MZA) reported pharmacological properties. We report here, for the first time, that MZA selectively inhibited a 90 kD

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Nakagawa, Masako, Yasuhiro Torisawa, Toshihiro Hosaka, et al. "Dihydropyridinone approach to manzamines: An expedient construction of the tetracyclic core of manzamine A." Tetrahedron Letters 34, no. 28 (1993): 4543–46. http://dx.doi.org/10.1016/0040-4039(93)88081-s.

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Samoylenko, Volodymyr, Shabana I. Khan, Melissa R. Jacob, et al. "Bioactive (+)-Manzamine A and (+)-8-Hydroxymanzamine A Tertiary Bases and Salts from Acanthostrongylophora Ingens and Their Preparations." Natural Product Communications 4, no. 2 (2009): 1934578X0900400. http://dx.doi.org/10.1177/1934578x0900400204.

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The genus Acanthostrongylophora is famous for producing a wide array of manzamine alkaloids as natural hydrochloride salts. An examination of A. ingens has now yielded two tertiary bases, (+)-8-hydroxymanzamine A (1) and (+)-manzamine A (2), by chromatography over alumina using CHCl3-MeOH-NH3·H2O as solvent. In addition, (+)-8-hydroxymanzamine A hydrochloride (3) and (+)-manzamine A hydrochloride (4) were isolated under the same conditions from the same source by silica gel chromatography. The structures of 1-4 were determined from 1D- and 2D-NMR spectra and by circular dichroism experiments,

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Watanabe, Daisuke, Masashi Tsuda, and Jun'ichi Kobayashi. "Three New Manzamine Congeners fromAmphimedonSponge." Journal of Natural Products 61, no. 5 (1998): 689–92. http://dx.doi.org/10.1021/np970564p.

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BORMAN, STU. "First synthesis of manzamine A." Chemical & Engineering News 76, no. 25 (1998): 7. http://dx.doi.org/10.1021/cen-v076n025.p007.

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Dissertations / Theses on the topic "Manzamine A"

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Townsend, Robert J. "Synthetic studies towards manzamine A." Thesis, University of Nottingham, 1999. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.266928.

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McMath, Alwyn Francis. "Synthetic studies towards manzamine A." Thesis, University of Salford, 2001. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.248879.

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Beck, Ellen Juliana. "Studies towards the synthesis of manzamine C." Thesis, University of New Brunswick, 1999. http://hdl.handle.net/1882/385.

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Beck, Ellen Juliana. "Studies towards the synthesis of manzamine C." Thesis, National Library of Canada = Bibliothèque nationale du Canada, 2000. http://www.collectionscanada.ca/obj/s4/f2/dsk1/tape2/PQDD_0035/NQ62167.pdf.

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Lee, May Ling. "Studies directed towards the synthesis of manzamine A." Thesis, National Library of Canada = Bibliothèque nationale du Canada, 1999. http://www.collectionscanada.ca/obj/s4/f2/dsk1/tape7/PQDD_0015/NQ46295.pdf.

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Hansen, Anna Mette. "Studies towards a total synthesis of manzamine A." Thesis, University of Glasgow, 2010. http://theses.gla.ac.uk/1775/.

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Manzamine A has been isolated from various Okinawa Sponges of the genus Haliclona and was first characterised by Higa and co-workers in 1986. The unusual and synthetically challenging structure consists of a pentacyclic core containing an array of 5-, 6-, 8-, and 13-membered rings with a pendant -carboline unit. The complex structure of manzamine A combined with its biological activities has made it a highly attractive synthetic target. The synthetic endeavors in the Clark group to develop a novel approach towards the total synthesis of manzamine A (i) with the main focus on the synthesis of t

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Fearnley, Stephen Philip. "Synthetic approaches towards manzamine A and related alkaloids." Thesis, University of Salford, 1992. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.334047.

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Crapnell, Katherine Mary. "Preparation of polycyclic amines and studies towards manzamine." Thesis, University of Exeter, 2000. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.324717.

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MAGNIER, EMMANUEL. "Nouvelle approche synthetique des alcaloides de type manzamine." Paris 11, 1997. http://www.theses.fr/1997PA112265.

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La manzamine a est le principal compose d'une famille de produits naturels, d'origine marine. En raison de sa structure originale, de son activite cytotoxique et de sa faible abondance a l'etat naturel, la manzamine a a suscite, depuis 1989, un interet croissant en synthese. Une synthese de cet alcaloide est envisagee a l'aide d'une reaction de bradsher stereoselective, entre un sel de 2,7-naphthyridinium et un ether d'enol convenablement choisi. Une etude modele a debouche sur la synthese stereoselective du cur tricyclique abc de la manzamine a. Au cours de ce travail, l'influence du solvant

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Filippini, Brian Bernard. "Studies toward the total synthesis of manzamine A /." The Ohio State University, 1995. http://rave.ohiolink.edu/etdc/view?acc_num=osu1487863429092887.

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Book chapters on the topic "Manzamine A"

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Duval, Romain, and Erwan Poupon. "Biomimetic Synthesis of Manzamine Alkaloids." In Biomimetic Organic Synthesis. Wiley-VCH Verlag GmbH & Co. KGaA, 2011. http://dx.doi.org/10.1002/9783527634606.ch6.

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Dixon, Darren J., and Pavol Jakubec. "Total Synthesis of Manzamine Alkaloids." In Topics in Heterocyclic Chemistry. Springer Singapore, 2021. http://dx.doi.org/10.1007/7081_2021_51.

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Hu, Jin-Feng, Mark T. Hamann, Russell Hill, and Michelle Kelly. "THE MANZAMINE ALKALOIDS." In The Alkaloids: Chemistry and Biology. Elsevier, 2003. http://dx.doi.org/10.1016/s0099-9598(03)60004-0.

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4

Kubota, Takaaki, Shin-ichiro Kurimoto, and Jun'ichi Kobayashi. "The manzamine alkaloids." In The Alkaloids. Elsevier, 2020. http://dx.doi.org/10.1016/bs.alkal.2020.03.001.

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Taber, Douglass F. "The Dixon Synthesis of Manzamine A." In Organic Synthesis. Oxford University Press, 2015. http://dx.doi.org/10.1093/oso/9780190200794.003.0100.

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The pentacyclic alkaloid manzamine A 4, isolated from a sponge collected in the Okinawa Sea, displays a range of antibacterial, anticancer, and antimalarial activity. The preparation of 4 reported (J. Am. Chem. Soc. 2012, 134, 17482) by Darren J. Dixon of the University of Oxford showcases the versatility of the nitro group in organic synthesis. The nitro alkene 2 was prepared from the commercial bromide 5. Displacement with acetate followed by Swern oxidation led to the aldehyde 6, which was condensed with nitromethane to give 2. Lactam 1 was an intermediate in Professor Dixon’s synthesis (Org. Highlights May 3, 2010) of (–)-nakadomarin A. Lactam 1 was prepared from the tosylate 7, which was derived from pyroglutamic acid. The addition of 1 to the nitroalkene 2 delivered 3 as the dominant diastereomer of the four that were possible. Mannich condensation with formaldehyde and the amine 12 gave 13. The nitro group of 13 was removed by free radical reduction. Exposure of the reduced product to trimethylsilyl iodide gave, via ionization of the ketal, the primary iodide, which was carried onto the nitro compound 14. Dibal selectively reduced the δ-lactam. Partial reduction of the γ-lactam then gave an intermediate that engaged in Mannich condensation with the nitro-activated methylene to give 15. Although there are many protocols for the conversion of a nitro compound to a ketone, most of those were not compatible with the functional groups of 15. Fortunately, Ti(III) was effective. Ce-mediated addition of the Grignard reagent 16 to the ketone followed by deprotection and protection then delivered the silyl ether 17. Remarkably, the ketone 17 could be deprotonated and carried on to the enol triflate 18 without eliminating the TMSO group. Coupling with the stannane 19 then completed the synthesis of manzamine A 4. One-carbon homologation of 18 led to ircinol A, ircinal A, and methyl ircinate (not illustrated).

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El-Desoky, Ahmed H. H., and Sachiko Tsukamoto. "Manzamines: Marine Bioactive Heterocycles." In Topics in Heterocyclic Chemistry. Springer Berlin Heidelberg, 2020. http://dx.doi.org/10.1007/7081_2020_42.

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Conference papers on the topic "Manzamine A"

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Kallifatidis, Georgios, Dominic Hoepfner, Sven Schuierer, Nicole Hartmann, Esther Guzmán, and Amy Wright. "Abstract A39: The marine natural product manzamine A targets vacuolar ATPases and autophagy in pancreatic cancer cells." In Abstracts: AACR Special Conference on Pancreatic Cancer: Progress and Challenges; June 18-21, 2012; Lake Tahoe, NV. American Association for Cancer Research, 2012. http://dx.doi.org/10.1158/1538-7445.panca2012-a39.

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