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Dissertations / Theses on the topic 'MAO_ inhibitors'

Author: Grafiati

Published: 5 June 2025

Last updated: 16 July 2025

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1

Vince, Matthew Joseph Kline. "Examining Monoamine Oxidase Inhibitor Targets Using Caenorhabditis elegans." Ohio University Art and Sciences Honors Theses / OhioLINK, 2020. http://rave.ohiolink.edu/etdc/view?acc_num=ouashonors1598384776888279.

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2

Senini, Vincent Wally James. "MAO-B inhibitors protect against lipopolysaccharide-mediated epithelial barrier loss and cytokine release." Thesis, University of British Columbia, 2011. http://hdl.handle.net/2429/36429.

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Epithelial tissues play a critical role in maintaining systemic health by establishing a functional barrier that separates the external environment from the host to provide an innate defense against environmental insult. Epithelial barrier disruption is suspected to play a central role in the onset of chronic inflammatory disease, although, fundamental knowledge of the underlying pathogenesis remains poorly understood. Thus, identifying factors that mediate epithelial barrier loss is clinically relevant as it will open the possibility that novel interventional strategies may be developed to mi

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3

MELEDDU, RITA. "Synthesis of different series of small molecules targeting HIV-1 RT, Candida albicans, MAO and G-Quadruplex." Doctoral thesis, Università degli Studi di Cagliari, 2013. http://hdl.handle.net/11584/266235.

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My PhD work has been focused towards four different targets: HIV-1 RT, Candida albicans, Monoamine oxidase, and G-Quadruplex. Thus in order to give the reader a clearer exposition this report has been divided in four different chapters. Each of the chapters has his own figures, schemes, tables and references. The main part of my work has been dedicated to HIV-1 RT, thus this chapter is the major and first one.

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4

Öhrngren, Per. "Tertiary Alcohol- or β-Hydroxy γ-Lactam-Based HIV-1 Protease Inhibitors : Microwave Applications in Batch and Continuous Flow Organic Synthesis". Doctoral thesis, Uppsala universitet, Avdelningen för organisk farmaceutisk kemi, 2011. http://urn.kb.se/resolve?urn=urn:nbn:se:uu:diva-160190.

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Since the outbreak of the HIV/AIDS pandemic in the 1980s, the disease has cost the lives of over 30 million people, and a further 33 million are currently living with the HIV infection. With the appropriate treatment, HIV/AIDS can today be regarded as a chronic but manageable disease. However, treatment is not available globally and UNAIDS still estimates that there are currently 5000 AIDS-related deaths worldwide per day. HIV protease inhibitors (PIs) constitute one of the fundaments of HIV treatment, and are commonly used in so-called highly active antiretroviral therapy (HAART), together wi

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5

Manley-King, Clarina Ilara. "The synthesis and evaluation of N-methyl-2-phenylmaleimide analogues as inhibitors of MAO-B / Clarina I. Manley-King." Thesis, North-West University, 2008. http://hdl.handle.net/10394/2130.

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6

Pazini, Andreia Martini. "SELEGILINA REVERTE A PIORA DA MEMÓRIA INUZIDA POR Aβ25-35 EM CAMUNDONGOS: ENVOLVIMENTO DA ATIVIDADE DA MAO-B". Universidade Federal de Santa Maria, 2013. http://repositorio.ufsm.br/handle/1/8996.

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Conselho Nacional de Desenvolvimento Científico e Tecnológico<br>Alzheimer s disease (AD) is biochemically characterized by the occurrence of extracellular deposits of amyloid beta peptide (Aβ) and intracellular deposits of the hyperphosphorylated tau protein, which are causally related to the pathological hallmarks senile plaques and neurofibrillary tangles. Monoamine oxidase B (MAO-B) activity, an enzyme involved in the oxidation of biogenic monoamines, is particularly high around the senile plaques and increased in AD patients in middle to late clinical stages of the disease. Selegiline, a

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7

Fasolo, Juliana Maria de Mello Andrade. "Aplicação de CLAE-DAD-EM e CG-EM na caracterização de Blechnum sp. e abordagens in vitro e in silico para a avaliar o perfil multifuncional do ácido rosmarínico em alvos relacionados à neurodegeneração e toxicidade em células-tronco." reponame:Biblioteca Digital de Teses e Dissertações da UFRGS, 2015. http://hdl.handle.net/10183/149457.

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As plantas medicinais são consideradas importantes fontes de compostos biologicamente ativos. Para muitas doenças crônicas, como as neurodegenerações, substâncias que apresentam atividades simultâneas em mais de um alvo relacionado à etiopatologia dessas desordens, constituem potenciais agentes terapêuticos. Nesse contexto, os objetivos deste trabalho foram a avaliação química e biológica de três espécies de samambaias de ocorrência no sul do Brasil: Blechnum binervatum, B. brasiliense e B. occidentale. O isolamento bioguiado foi utilizado para a identificação da(s) substância(s) com potencial

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8

Villarinho, Jardel Gomes. "POTENCIAL ANTIDEPRESSIVO E ANALGÉSICO DO 2-(3,4-DIMETOXI-FENIL)-4,5-DIIDRO-1H-IMIDAZOL (2-DMPI) EM CAMUNDONGOS." Universidade Federal de Santa Maria, 2012. http://repositorio.ufsm.br/handle/1/3835.

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Coordenação de Aperfeiçoamento de Pessoal de Nível Superior<br>Depression and chronic pain coexist in several patients and may be modulated by the same neurotransmitter systems. In this context, various studies have demonstrated that antidepressants from the class of the inhibitors of monoamine oxidase-A (MAO-A) enzyme presented antinociceptive effect in different pain models in experimental animals, as well as analgesic action in clinic studies. Thus, in the present study were evaluated the MAO-A inhibitory properties, as well as the antidepressant and antinociceptive potential of the novel i

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9

Oliveira, Dayanne Rakelly de. "SILIMARINA MODIFICA A ATIVIDADE DA NA+/K+-ATPASE E DA MAO E MODULA A AÇÃO DE ANTIMICROBIANOS IN VITRO." Universidade Federal de Santa Maria, 2015. http://repositorio.ufsm.br/handle/1/4493.

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Coordenação de Aperfeiçoamento de Pessoal de Nível Superior<br>The Silymarin is a flavonolignan complex isolated from milk thistle seeds of Silybum marianum being used in the treatment of injury related to oxidative stress, including liver and neurological diseases, as Parkinson disease. Although silymarin has been reported to possess a variety of pharmacological properties including anti-inflammatory, anticarcinogenic and neuroprotective effects, information regard its antimicrobial and drug modulator potential against microbial resistance is scanty in the literature. In addition, the possibl

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10

Denis, Alexis. "Fonctionnalisations selectives a l'aide des complexes du palladium : synthese de composes d'interet biologiques, cyclopropanes vinyliques, aryl-3 oxazolidinones-2 (inhibiteurs potentiels de la monoamine oxydase)." Paris 6, 1987. http://www.theses.fr/1987PA066335.

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Ce travail porte sur l'utilisation du palladium (o) pour la synthese de molecules d'interet biologique. En premier lieu, on decrit la synthese stereoselective de cyclopropanes vinyliques et de pyrethrinoides. Dans un second temps, on etudie l'echange acetate phenol et l'amination de derives allyliques fibonctionnels. Enfin, on presente la synthese d'aryl-3 dihydroxy-5,5 oxazolidones-2 erythro et threo et etudie leur utilisation en tant qu'inhibiteur d'enzyme monoamine oxidase

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11

Mesfioui, Abdelhalem ben Mehdi. "Contribution à l'étude des mécanismes mis en jeu dans les flux transmembranaires de neurotransmetteurs : Action de l'amphétamine, de la phényléthylamine et de la tranylcypromine sur la libération des catécholamines et l'activité des composantes du système de l'adénosine triphosphatase." Nancy 1, 1988. http://www.theses.fr/1988NAN10187.

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De façon classique, la libération des neurotransmetteurs au niveau synaptique implique un mécanisme d'exocytose nécessitant la médiation d'ions calcium. Cette libération peut se produire en absence de calcium extracellulaire ; elle dépend alors du gradient sodique trasmembranaire et sera modulée par tout paramètre affectant l'amplitude de ce gradient notamment l'activité (Na+,K+)-ATPasique, expression enzymatique de la pompe à sodium. Nous avons entrepris une analyse de ce mécanisme par une expérimentation in vivo et in vitro portant sur l'action de l'amphétamine et de composés apparentés (phé

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12

Nemčíková, Lenka. "Propargyltakriny - inhibitory acetylcholinesterasy s anti-MAO aktivitou." Master's thesis, 2018. http://www.nusl.cz/ntk/nusl-380455.

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Charles University Faculty of Pharmacy in Hradec Králové Department of Pharmaceutical Chemistry and Pharmaceutical Analysis Student: Lenka Nemčíková Supervisor: PharmDr. Marta Kučerová, Ph.D. Title of Thesis: Propargyltacrines - acetylcholinesterase inhibitors with anti-MAO activity Alzheimer's disease (AD) is a serious neurodegenerative disorder that affects mainly aged people. Neurodegenerative disorders lead to dementia. However, dementia is not a part of normal aging. It is the result of pathologigal process. Alois Alzheimer was the first who described AD. The causes of this disease are no

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13

Parsons, Austin. "The treatment of Parkinson's disease using MAO-B inhibitors." Thesis, 2017. https://hdl.handle.net/2144/23854.

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Monoamine Oxidase Inhibitors have sparked great controversy in the treatment of idiopathic Parkinson’s Disease. There is little doubt that Monoamine Oxidase Inhibitors work synergistically with Levodopa to reduce several major debilitating symptoms. Multiple other medications provide a similar symptomatic benefit when combined with Levodopa; thus, a symptomatic benefit alone does little to advance current Parkinson’s treatment. The great controversy in treatment then comes from the possibility that Monoamine Oxidase Inhibitors modify the natural course of Parkinson’s Disease. This class of dru

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14

Ho, Ming-che, and 何明哲. "Natural and Cocaine Reward in Chronically MAO Inhibitor-treated and MAO Subtype B knockout Mice." Thesis, 2007. http://ndltd.ncl.edu.tw/handle/09700151491379579480.

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碩士<br>國立成功大學<br>行為醫學研究所<br>95<br>A large body of evidence supports the hypothesis that monoamines are involved in the cocaine craving and associated behavior. Cocaine has been known to block reuptake of these neurotransmitters by inhibiting their own transporters, thus enhance synaptic availability of these neurotransmitters. Increased synaptic monoamine concentration have been associated with the euphoric (reinforcing) efficacy and the priming effects of cocaine in reinstatement designs. In this study, the acquisition curve of cocaine self administration was examined in MAO subtype B knockout

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15

Engelbrecht, Idalet. "Synthesis and evaluation of sesamol derivatives as inhibitors of monoamine oxidase / Idalet Engelbrecht." Thesis, 2014. http://hdl.handle.net/10394/15218.

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Parkinson’s disease is an age-related neurodegenerative disorder. The major symptoms of Parkinson’s disease are closely linked to the pathology of the disease. The main pathology of Parkinson’s disease consists of the degeneration of neurons of the substantia nigra pars compacta (SNpc), which leads to reduced amounts of dopamine in the brain. One of the treatment strategies in Parkinson’s disease is to conserve dopamine by inhibiting the enzymes responsible for its catabolism. The monoamine oxidase (MAO) B isoform catalyses the oxidation of dopamine in the central nervous system and is therefo

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16

Chen, Cheng-Tang, and 陳正唐. "INHIBITORY PRINCIPLES OF UNCARIA RHYNCHOPHLLA ON MONOAMINE OXIDASE B (MAO B)." Thesis, 2002. http://ndltd.ncl.edu.tw/handle/52197272394142348207.

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碩士<br>台北醫學院<br>生藥學研究所<br>90<br>Monoamine oxidase (MAO) is a flavin-containing enzyme, which catalyzes the oxidation of a variety of amine-containing neurotransmitters (such as serotonin, dopamine and norepinephrine) to yield the corresponding aldehydes and the coproducts hydrogen peroxide (H2O2) and ammonia. It exists MAO-A and MAO-B forms. The attenuation of MAO-B activity may provide protection against oxidative neurodegeneration for treatment of Parkinson’s and Alzheimer’s patients. Gou-teng，the hook of Uncaria rhynchophylla（Miq.）Jacks., is a Chinse herb used for an antihypertensive therapy

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17

Pinto, Miguel Rocha Vaz. "Development of effective PEGylated PCL-based nanoformulations for the delivery of potent MAO-B chromone-based inhibitors." Master's thesis, 2017. https://repositorio-aberto.up.pt/handle/10216/110734.

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18

Pinto, Miguel Rocha Vaz. "Development of effective PEGylated PCL-based nanoformulations for the delivery of potent MAO-B chromone-based inhibitors." Dissertação, 2017. https://repositorio-aberto.up.pt/handle/10216/110734.

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