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1

Suzuki, Selly Sayuri, Laila Fernanda Souza Braga, Denise Nami Fujii, Won Moon, and Hideo Suzuki. "Corticopuncture Facilitated Microimplant-Assisted Rapid Palatal Expansion." Case Reports in Dentistry 2018 (December 6, 2018): 1–12. http://dx.doi.org/10.1155/2018/1392895.

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Introduction. Microimplant-assisted rapid palatal expansion (MARPE) has been considered an alternative to avoid extensive surgical procedures. In order to obtain skeletal results of MARPE, force should be enough to overcome areas of resistance and the first one that is required to be disrupted is the midpalatal suture, which becomes increasingly interdigitated after adolescence. Objective. The present study aimed at providing a novel approach using a minimally invasive method called corticopuncture (CP) in association with MARPE illustrated by a case report of a 35-year-old Brazilian female Ca
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2

Kost, Rhonda G., Leslie Boone, Sarah Cook, et al. "4113 Infusing a CTSA Program with Causal Pathway Thinking to Transform Evaluation from Operations to Impacts." Journal of Clinical and Translational Science 4, s1 (2020): 73–74. http://dx.doi.org/10.1017/cts.2020.240.

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OBJECTIVES/GOALS: Innovations with positive health impact are a high priority for NCATS and CTSAs. Program design that uses the Causal Pathway approach incorporates performance indicators that assess impact. We applied Causal Pathway thinking to an ongoing national program to enhance the evaluation of program impact. We report Lessons Learned. METHODS/STUDY POPULATION: We conducted a day-long onsite workshop to introduce the model to the project team, build capacity, and map the existing program elements to Logic Models representing program Specific Aims. A local Causal Pathway (CP) champion w
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3

Balmori-Melian, Ezequiel, Robin M. MacDiarmid, David L. Beck, Richard C. Gardner, and Richard L. S. Forster. "Sequence-, Tissue-, and Delivery-Specific Targeting of RNA During Post-Transcriptional Gene Silencing." Molecular Plant-Microbe Interactions® 15, no. 8 (2002): 753–63. http://dx.doi.org/10.1094/mpmi.2002.15.8.753.

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Transgenic Nicotiana benthamiana plants expressing an untranslatable version of the coat protein (CP) gene from the Tamarillo mosaic virus (TaMV) were either resistant to TaMV infection or recovered from infection. These phenotypes were the result of a post-transcriptional gene silencing (PTGS) mechanism that targeted TaMV-CP sequences for degradation. The TaMV-CP sequences were degraded when present in the wild-type TaMV potyvirus, in transgene mRNA, or in chimeric viral vectors based on White clover mosaic virus. The more efficiently targeted region was mapped to a 134-nt segment. Difference
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4

Bud, Eugen-Silviu, Mariana Păcurar, Alexandru Vlasa, et al. "Retrospective Case Series Regarding the Advantages of Cortico-Puncture (CP) Therapy in Association with Micro-Implant Assisted Rapid Palatal Expander (MARPE)." Applied Sciences 11, no. 3 (2021): 1306. http://dx.doi.org/10.3390/app11031306.

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Transverse maxillary deficiency currently affects 8–23% of adults. One of the most widely used orthodontic treatments today in patients with transverse maxillary defects is the maxillary skeletal expander (MSE). This was a retrospective observational imaging study regarding structural bone changes that may occur during healing after the placement of micro-implant assisted rapid palatal expanders (MARPE) in combination with cortico-puncture (CP) therapy. Regarding the magnitude of the mid-palatal suture opening, the mean split at the anterior nasal spine (ANS) and the posterior nasal spine (PNS
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Tagnon, Bertrand Ouesse, Theophile Lasm, Aristide G. Douagui, and Issiaka Savane. "Statistical and Geostatistical Analysis of Lineaments Network Mapped in The Precambrian Basement: Case of Divo-Oume Region (Southern Cote d’Ivoire)." European Scientific Journal, ESJ 12, no. 33 (2016): 299. http://dx.doi.org/10.19044/esj.2016.v12n33p299.

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The high populated and dense agricultural region of Divo-Oumé, in the southern part of Côte d’Ivoire, periodically faces drinking water scarcity and lack of reliable water resources management tools. This study presents a statistical and geostatistical analysis of lineaments network, conducted in Divo-Oumé region, in order to contribute to a better understanding of local Precambrian basement aquifer. Fractures network has been characterized through the analysis of the attributes of lineaments derived from conjoint Radarsat and Asar images. The average length of lineaments is 2.15 km and around
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Molteno, Timothy C. A. "Nature’s Wind Turbines: The Measured Aerodynamic Efficiency of Spinning Seeds Approaches Theoretical Limits." Biomimetics 7, no. 4 (2022): 161. http://dx.doi.org/10.3390/biomimetics7040161.

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This paper describe a procedure to measure experimentally the power coefficient, Cp, of winged seeds, and apply this technique to seeds from the Norway maple (Acer platanoides). We measure Cp=56.9±2% at a tip speed ratio of 3.21±0.06. Our results are in agreement with previously published CFD simulations that indicate that these seeds—operating in low-Reynolds number conditions—approach the Betz limit (Cp=59.3%) the maximum possible efficiency for a wind turbine. In addition, this result is not consistent with the recent theoretical work of Okulov & Sørensen, which suggests that a single-b
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7

Rajamäki, M., A. Merits, F. Rabenstein, et al. "Biological, Serological, and Molecular Differences Among Isolates of Potato A Potyvirus." Phytopathology® 88, no. 4 (1998): 311–21. http://dx.doi.org/10.1094/phyto.1998.88.4.311.

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Sequences of the coat protein (CP) and 3′-end nontranslated region (3′NTR) of 13 isolates and the helper component proteinase (HC) of nine isolates of potato A potyvirus (PVA) were determined and compared with the eight previously determined PVA CP and 3′NTR sequences and one HC sequence. CP amino acid (aa), 3′NTR nucleotide, and HC aa sequence identities were 92.9, 93.4, and 94.8%, respectively. Sequence data, serological tests, and the necrotic local lesions induced in the leaves of the potato hybrid ‘A6’ confirmed that tamarillo mosaic virus is a strain of PVA. The aa substitutions A6T and
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8

Negm, Walaa, Aya H. El-Kadem, Ismail A. Hussein, and Moneerah J. Alqahtani. "The Mechanistic Perspective of Bilobetin Protective Effects against Cisplatin-Induced Testicular Toxicity: Role of Nrf-2/Keap-1 Signaling, Inflammation and Apoptosis." Biomedicines 10, no. 5 (2022): 1134. http://dx.doi.org/10.3390/biomedicines10051134.

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Cisplatin (CP) is a productive anti-tumor used to treat numerous tumors. However, multiple toxicities discourage prolonged use, especially toxicity on the reproductive system. This experiment was mapped out to determine the potential therapeutic impact of Bilobetin on CP-induced testicular damage. Herein, Bilobetin was isolated from Cycas thouarsii leaves R. Br ethyl acetate fractions for the first time. A single dose of CP (7 mg/kg, IP) was used to evoke testicular toxicity on the third day. Rats were classified into five groups; Normal control, Bilobetin 12 mg/kg, Untreated CP, and CP treate
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9

Paul, André, Stefan Mulitza, Rüdiger Stein, and Martin Werner. "A global climatology of the ocean surface during the Last Glacial Maximum mapped on a regular grid (GLOMAP)." Climate of the Past 17, no. 2 (2021): 805–24. http://dx.doi.org/10.5194/cp-17-805-2021.

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Abstract. We present a climatology of the near-sea-surface temperature (NSST) anomaly and the sea-ice extent during the Last Glacial Maximum (LGM, 23 000–19 000 years before present) mapped on a global regular 1∘×1∘ grid. It is an extension of the Glacial Atlantic Ocean Mapping (GLAMAP) reconstruction of the Atlantic NSST based on the faunal and floral assemblage data of the Multiproxy Approach for the Reconstruction of the Glacial Ocean Surface (MARGO) project and several recent estimates of the LGM sea-ice extent. Such a gridded climatology is highly useful for the visualization of the LGM c
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10

Aparicio, Frederic, Jesús A. Sánchez-Navarro, and Vicente Pallás. "In vitro and in vivo mapping of the Prunus necrotic ringspot virus coat protein C-terminal dimerization domain by bimolecular fluorescence complementation." Journal of General Virology 87, no. 6 (2006): 1745–50. http://dx.doi.org/10.1099/vir.0.81696-0.

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Interactions between viral proteins are critical for virus viability. Bimolecular fluorescent complementation (BiFC) technique determines protein interactions in real-time under almost normal physiological conditions. The coat protein (CP) of Prunus necrotic ringspot virus is required for multiple functions in its replication cycle. In this study, the region involved in CP dimerization has been mapped by BiFC in both bacteria and plant tissue. Full-length and C-terminal deleted forms of the CP gene were fused in-frame to the N- and C-terminal fragments of the yellow fluorescent protein. The Bi
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11

Thompson, Kelsey B., Monte G. Bateman, and Lawrence D. Carey. "A Comparison of Two Ground-Based Lightning Detection Networks against the Satellite-Based Lightning Imaging Sensor (LIS)." Journal of Atmospheric and Oceanic Technology 31, no. 10 (2014): 2191–205. http://dx.doi.org/10.1175/jtech-d-13-00186.1.

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Abstract Lightning stroke data from both the World Wide Lightning Location Network (WWLLN) and the Earth Networks Total Lightning Network (ENTLN) were compared to lightning group data from the Lightning Imaging Sensor (LIS) from 1 January 2010 through 30 June 2011. The region of study, from 39°S to 39°N latitude, chosen based on the orbit of LIS, and 164°E east to 17°W longitude, chosen to approximate the possible Geostationary Lightning Mapper (GLM) longitude, was considered in its entirety and then divided into geographical subregions. Over this 18-month time period, WWLLN had an 11.0% entir
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12

Hong, Eunmee M., Rushika Perera, and Richard J. Kuhn. "Alphavirus Capsid Protein Helix I Controls a Checkpoint in Nucleocapsid Core Assembly." Journal of Virology 80, no. 18 (2006): 8848–55. http://dx.doi.org/10.1128/jvi.00619-06.

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ABSTRACT The assembly of the alphavirus nucleocapsid core has been investigated using an in vitro assembly system. The C-terminal two-thirds of capsid protein (CP), residues 81 to 264 in Sindbis virus (SINV), have been previously shown to have all the RNA-CP and CP-CP contacts required for core assembly in vitro. Helix I, which is located in the N-terminal dispensable region of the CP, has been proposed to stabilize the core by forming a coiled coil in the CP dimer formed by the interaction of residues 81 to 264. We examined the ability of heterologous alphavirus CPs to dimerize and form pheno
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13

Heath, Livio, Anna-Lise Williamson, and Edward P. Rybicki. "The Capsid Protein of Beak and Feather Disease Virus Binds to the Viral DNA and Is Responsible for Transporting the Replication-Associated Protein into the Nucleus." Journal of Virology 80, no. 14 (2006): 7219–25. http://dx.doi.org/10.1128/jvi.02559-05.

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ABSTRACT Circoviruses lack an autonomous DNA polymerase and are dependent on the replication machinery of the host cell for de novo DNA synthesis. Accordingly, the viral DNA needs to cross both the plasma membrane and the nuclear envelope before replication can occur. Here we report on the subcellular distribution of the beak and feather disease virus (BFDV) capsid protein (CP) and replication-associated protein (Rep) expressed via recombinant baculoviruses in an insect cell system and test the hypothesis that the CP is responsible for transporting the viral genome, as well as Rep, across the
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14

Qiu, Wenping, and Karen-Beth G. Scholthof. "Genetic Identification of Multiple Biological Roles Associated with the Capsid Protein of Satellite Panicum Mosaic Virus." Molecular Plant-Microbe Interactions® 14, no. 1 (2001): 21–30. http://dx.doi.org/10.1094/mpmi.2001.14.1.21.

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Satellite panicum mosaic virus (SPMV), an 824-nucleotide, positive-sense, single-stranded RNA virus, depends on Panicum mosaic virus (PMV) for replication and spread in host plants. Compared with PMV infection alone, symptoms are intensified and develop faster on millet plants infected with SPMV and PMV. SPMV encodes a 157 amino acid capsid protein (CP) (17.5 kDa) to encapsidate SPMV RNA and form T = 1 satellite virions. The present study identifies additional biological activities of the SPMV CP, including the induction of severe chlorosis on proso millet plants (Panicum miliaceum cv. Sunup o
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15

Herzog, Etienne, Orlene Guerra-Peraza, and Thomas Hohn. "The Rice Tungro Bacilliform Virus Gene II Product Interacts with the Coat Protein Domain of the Viral Gene III Polyprotein." Journal of Virology 74, no. 5 (2000): 2073–83. http://dx.doi.org/10.1128/jvi.74.5.2073-2083.2000.

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ABSTRACT Rice tungro bacilliform virus (RTBV) is a plant pararetrovirus whose DNA genome contains four genes encoding three proteins and a large polyprotein. The function of most of the viral proteins is still unknown. To investigate the role of the gene II product (P2), we searched for interactions between this protein and other RTBV proteins. P2 was shown to interact with the coat protein (CP) domain of the viral gene III polyprotein (P3) both in the yeast two-hybrid system and in vitro. Domains involved in the P2-CP association have been identified and mapped on both proteins. To determine
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16

Carbonell, Alberto, Varvara I. Maliogka, José de Jesús Pérez, et al. "Diverse Amino Acid Changes at Specific Positions in the N-Terminal Region of the Coat Protein Allow Plum pox virus to Adapt to New Hosts." Molecular Plant-Microbe Interactions® 26, no. 10 (2013): 1211–24. http://dx.doi.org/10.1094/mpmi-04-13-0093-r.

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Plum pox virus (PPV)-D and PPV-R are two isolates from strain D of PPV that differ in host specificity. Previous analyses of chimeras originating from PPV-R and PPV-D suggested that the N terminus of the coat protein (CP) includes host-specific pathogenicity determinants. Here, these determinants were mapped precisely by analyzing the infectivity in herbaceous and woody species of chimeras containing a fragment of the 3′ region of PPV-D (including the region coding for the CP) in a PPV-R backbone. These chimeras were not infectious in Prunus persica, but systemically infected Nicotiana clevela
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17

Haldeman-Cahill, Ruth, José-Antonio Daròs, and James C. Carrington. "Secondary Structures in the Capsid Protein Coding Sequence and 3′ Nontranslated Region Involved in Amplification of the Tobacco Etch Virus Genome." Journal of Virology 72, no. 5 (1998): 4072–79. http://dx.doi.org/10.1128/jvi.72.5.4072-4079.1998.

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ABSTRACT The 3′-terminal 350 nucleotides of the tobacco etch potyvirus (TEV) genome span the end of the capsid protein (CP)-coding sequence and the 3′ nontranslated region (NTR). The CP-coding sequence within this region contains a 105-nucleotide cis-active element required for genome replication (S. Mahajan, V. V. Dolja, and J. C. Carrington, J. Virol. 70:4370–4379, 1996). To investigate the sequence and secondary structure requirements within the CP cis-active region and the 3′ NTR, a systematic linker-scanning mutagenesis analysis was done. Forty-six mutations, each with two to six nucleoti
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18

Curran, Paytin, DeLaney Anderson, Jeffrey Okojie, et al. "Abstract 5034: Comparative whole genome sequencing between matched cryopreserved and FFPE tumor samples." Cancer Research 85, no. 8_Supplement_1 (2025): 5034. https://doi.org/10.1158/1538-7445.am2025-5034.

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Background & Aims: Next generation sequencing, specifically whole genome sequencing (WGS), plays a key role in precision medicine. Currently, the main source of cancer biospecimens for WGS is formalin-fixed, paraffin-embedded (FFPE) tissues. This is partly because cryopreserved (CP) tissues have not been routinely stored in real-world clinical settings. This study aimed to compare the outcomes of WGS by using matched CP and FFPE samples. We hypothesized that CP samples would demonstrate superior quality metrics before and after sequencing the DNA. Methods: A total of 50 matched pairs of CP
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CASTELL, A. G., and R. L. CLIPLEF. "PERFORMANCE AND CARCASS RESPONSES TO DIETARY INCLUSION OF RAW SOYBEANS (CV. MAPLE AMBER) BY BOARS FED AD LIBITUM FROM 30 TO 95 KILOGRAMS LIVEWEIGHT." Canadian Journal of Animal Science 68, no. 1 (1988): 275–82. http://dx.doi.org/10.4141/cjas88-028.

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Cull raw soybeans (SB), cv. Maple Amber, containing 17% oil and 36% crude protein (CP), were included as 0, 4.5, 9, 13.5, 18 and 22.5% of barley-based diets formulated to contain 16% CP. The mash diets were fed ad libitum to a total of 53 Landrace boars over the period from 30 to 95 kg average liveweight using a randomized block design with three replicates. Live performance responses to the increase in dietary SB content included a decline in overall growth rate (from 830 to 639 g d−1, P < 0.01) and efficiency of feed conversion (from 333 to 269 g gain per kg feed, P < 0.01). Post-kill
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Loreggia, Andrea, Roberta Calegari, Emiliano Lorini, Francesca Rossi, and Giovanni Sartor. "How to model contrary-to-duty with GCP-nets." Intelligenza Artificiale 16, no. 2 (2022): 185–98. http://dx.doi.org/10.3233/ia-221057.

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Preferences are ubiquitous in our everyday life. They are essential in the decision making process of individuals. Recently, they have also been employed to represent ethical principles, normative systems or guidelines. In this work we focus on a ceteris paribus semantics for deontic logic: a state of affairs where a larger set of respected prescriptions is preferable to a state of affairs where some are violated. Conditional preference networks (CP-nets) are a compact formalism to express and analyse ceteris paribus preferences, with some desirable computational properties. In this paper, we
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Wang, Yuelong, Jiaojiao Deng, Lin Wang, et al. "Expression and clinical significance of PD-L1, B7-H3, B7-H4 and VISTA in craniopharyngioma." Journal for ImmunoTherapy of Cancer 8, no. 2 (2020): e000406. http://dx.doi.org/10.1136/jitc-2019-000406.

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BackgroundCraniopharyngioma (CP) is a common refractory tumor of the central nervous system. However, little is known about the expression and clinical significance of B7 family ligands/receptors in CP patients. Thus, we conducted the present study to address this issue in a cohort of 132 CP cases.MethodsWe mapped and quantified the expression of B7 family ligands/receptors molecules programmed cell death ligand 1 (PD-L1), B7-H3, B7-H4 and V-domain Ig-containing suppressor of T cell activation (VISTA) in 89 adamantinomatous-type CP and 43 papillary-type CP samples using immunohistochemistry an
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Yoo, Lina, and Samuel H. Speck. "Determining the Role of the Epstein-Barr Virus Cp EBNA2-Dependent Enhancer during the Establishment of Latency by Using Mutant and Wild-Type Viruses Recovered from Cottontop Marmoset Lymphoblastoid Cell Lines." Journal of Virology 74, no. 23 (2000): 11115–20. http://dx.doi.org/10.1128/jvi.74.23.11115-11120.2000.

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ABSTRACT Epstein-Barr virus (EBV) nuclear antigen (EBNA) 2 (EBNA2) is involved in upregulating the expression of both EBNAs and latency-associated membrane proteins. Transcription of the six EBNA genes, which are expressed in EBV-immortalized primary B cells, arises from one of two promoters, Cp and Wp, located near the left end of the viral genome. Wp is exclusively used to drive EBNA gene transcription during the initial stages of infection in primary B cells; induction of transcription from Cp follows. We previously have mapped an EBNA2-dependent enhancer upstream of Cp (M. Woisetschlaeger
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23

Cafa, Giovanni, Riccardo Baroncelli, Carol A. Ellison, and Daisuke Kurose. "Impatiens glandulifera (Himalayan balsam) chloroplast genome sequence as a promising target for populations studies." PeerJ 8 (March 24, 2020): e8739. http://dx.doi.org/10.7717/peerj.8739.

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Background Himalayan balsam Impatiens glandulifera Royle (Balsaminaceae) is a highly invasive annual species native of the Himalayas. Biocontrol of the plant using the rust fungus Puccinia komarovii var. glanduliferae is currently being implemented, but issues have arisen with matching UK weed genotypes with compatible strains of the pathogen. To support successful biocontrol, a better understanding of the host weed population, including potential sources of introductions, of Himalayan balsam is required. Methods In this molecular study, two new complete chloroplast (cp) genomes of I. glanduli
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Bhatnagar, Surbhi, Alexis Mitelpunkt, Juliana J. Rizzo, et al. "Mental Health Diagnoses Risk Among Children and Young Adults With Cerebral Palsy, Chronic Conditions, or Typical Development." JAMA Network Open 7, no. 7 (2024): e2422202. http://dx.doi.org/10.1001/jamanetworkopen.2024.22202.

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ImportanceMental health (MH) issues in children with cerebral palsy (CP) are poorly understood compared with other pediatric populations.ObjectiveTo examine MH diagnosis code assignment among children and young adults with CP and compare with typically developing (TD) and chronic condition (CC) pediatric populations.Design, Setting, and ParticipantsThis case-control study used International Statistical Classification of Diseases, Tenth Revision, Clinical Modification (ICD-10-CM) codes to create a CP case set and CC and TD control sets using electronic health record data of children and young a
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SIAHKOLAEE, SEDIGHEH NIKZAT, MASOUD SHEIDAI, MOSTAFA ASSADI, and ZAHRA NOORMOHAMMADI. "Do we have different varieties in Acer velutinum (Sapindaceae): Morphological and molecular studies." Phytotaxa 321, no. 2 (2017): 151. http://dx.doi.org/10.11646/phytotaxa.321.2.1.

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The genus Acer L. has about 156 species which are distributed in Asia, Europe, Northern Africa and North America. The species of Acer show extensive morphological and molecular diversity and the species that co-occur may hybridize; therefore, sometimes the species delimitation turns out to be difficult. Eight Acer (maple) species have been reported in Iran. The velvet maple—Acer velutinum Boiss (1846: 28)—is one of the largest maples in the world and the most frequent maple species in Iran. Morphologically speaking, two varieties have been cited for this species. Due to the extensive morpholog
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Navarro-Almaida, D., A. Fuente, L. Majumdar, et al. "Evolutionary view through the starless cores in Taurus." Astronomy & Astrophysics 653 (August 31, 2021): A15. http://dx.doi.org/10.1051/0004-6361/202140820.

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Context. The chemical and physical evolution of starless and pre-stellar cores are of paramount importance to understanding the process of star formation. The Taurus Molecular Cloud cores TMC 1-C and TMC 1-CP share similar initial conditions and provide an excellent opportunity to understand the evolution of the pre-stellar core phase. Aims. We investigated the evolutionary stage of starless cores based on observations towards the prototypical dark cores TMC 1-C and TMC 1-CP. Methods. We mapped the prototypical dark cores TMC 1-C and TMC 1-CP in the CS 3 → 2, C34S 3 → 2, 13CS 2 → 1, DCN 1 → 0,
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Byeon, Seo Yeon, Kyeong-Sik Cheon, Sangil Kim, et al. "Comparative Analysis of Sequence Polymorphism in Complete Organelle Genomes of the ‘Golden Tide’ Seaweed Sargassum horneri between Korean and Chinese Forms." Sustainability 12, no. 18 (2020): 7280. http://dx.doi.org/10.3390/su12187280.

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Drifting and inundating brown seaweed Sargassum horneri biomass is called “golden tide”, as it resembles golden massive algal blooms like green tides. This phenomenon occurs globally and its serious ecological impacts on coastal ecosystems have recently begun to be paid attention to. In the present study, by sequencing whole organelle genomes of Korean indigenous S. horneri, we aimed to develop novel molecular markers that can be used for differentiating indigenous from nonindigenous individuals. To this end, we analyzed sequence polymorphisms in mitochondrial (mt) and chloroplast (cp) genomes
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Donda, Bhanu Priya, Sridhar Jarugula, and Rayapati A. Naidu. "An Analysis of the Complete Genome Sequence and Subgenomic RNAs Reveals Unique Features of the Ampelovirus, Grapevine leafroll-associated virus 1." Phytopathology® 107, no. 9 (2017): 1069–79. http://dx.doi.org/10.1094/phyto-02-17-0061-r.

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Despite being the first closterovirus documented in grapevines (Vitis sp.), the molecular biology of Grapevine leafroll-associated virus 1 (GLRaV-1, genus Ampelovirus, family Closteroviridae) is still in its infancy. In this study, the complete genome sequence of two GLRaV-1 isolates was determined to be 18,731 (isolate WA-CH) and 18,946 (isolate WA-PN) nucleotides (nt). The genome of WA-CH and WA-PN isolates encodes nine putative open reading frames (ORFs) and the arrangement of these ORFs in both isolates was similar to that of Australian and Canadian isolates. In addition to two divergent c
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Cronin, Anna, Sharynne McLeod, and Sarah Verdon. "Applying the ICF-CY to Specialist Speech-Language Pathologists’ Practice With Toddlers With Cleft Palate Speech." Cleft Palate-Craniofacial Journal 57, no. 9 (2020): 1105–16. http://dx.doi.org/10.1177/1055665620918799.

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Objective: To evaluate how the practice of specialist speech-language pathologists (SLPs) working with young children with cleft palate ± cleft lip (CP±L) maps onto the International Classification of Functioning, Disability, and Health – Children and Youth version (ICF-CY) and consider the functionality of the categories of the ICF-CY for this specialist area of practice. Design: Cross-sectional, qualitative study. Setting: Semistructured face-to-face interviews were conducted with SLPs working in tertiary-level hospitals, universities, and public clinics. Participants: Six specialist SLPs wi
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Askari, Mohammad Sadegh, Timothy McCarthy, Aidan Magee, and Darren J. Murphy. "Evaluation of Grass Quality under Different Soil Management Scenarios Using Remote Sensing Techniques." Remote Sensing 11, no. 15 (2019): 1835. http://dx.doi.org/10.3390/rs11151835.

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Hyperspectral and multispectral imagery have been demonstrated to have a considerable potential for near real-time monitoring and mapping of grass quality indicators. The objective of this study was to evaluate the efficiency of remote sensing techniques for quantification of aboveground grass biomass (BM) and crude protein (CP) in a temperate European climate such as Ireland. The experiment was conducted on 64 plots and 53 paddocks with varying quantities of nitrogen applied. Hyperspectral imagery (HSI) and multispectral imagery (MSI) were analyzed to develop the prediction models. The MSI da
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Freik, D. M., B. P. Volochanska, and T. O. Parashchuk. "Thermodynamic Parameters of PbTe Crystals: DFT-Calculations." Фізика і хімія твердого тіла 16, no. 1 (2015): 28–33. http://dx.doi.org/10.15330/pcss.16.1.28-33.

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Based on the analysis of the crystal NaCl type and electronic structure of cubic phase CdS crystals the cluster models have been built for calculation of the geometric and thermodynamic parameters. According to density functional theory (DFT) and using the hybrid valence base set B3LYP the temperature dependence of the energy ΔE and the enthalpy ΔH of formation, Gibbs free energy ΔG, entropy ΔS, specific heat at constant volume CV and pressure CP of the crystals have been found. The analytical expressions of the temperature dependences of presented thermodynamic parameters which was approximat
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32

Volochanska, B. P. "Thermodynamic Parameters of Lead Sulfide Crystals in the Cubic Phase." Фізика і хімія твердого тіла 16, no. 4 (2015): 649–53. http://dx.doi.org/10.15330/pcss.16.4.649-653.

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Geometric and thermodynamic parameters of cubic PbS crystals were obtained using the computer calculations of the thermodynamic parameters within density functional theory method DFT. Cluster models for the calculation were based on the analysis of the crystal and electronic structure. Temperature dependence of energy ΔE and ΔH enthalpy, Gibbs free energy ΔG, heat capacity at constant pressure CP and volume CV, entropy ΔS were determined on the basis of ab initio calculations of the crystal structure of molecular clusters. Analytical expressions of temperature dependences of thermodynamic para
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33

Foley, Daniel, Prasad Thenkabail, Adam Oliphant, Itiya Aneece, and Pardhasaradhi Teluguntla. "Crop Water Productivity from Cloud-Based Landsat Helps Assess California’s Water Savings." Remote Sensing 15, no. 19 (2023): 4894. http://dx.doi.org/10.3390/rs15194894.

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Demand for food and water are increasing while the extent of arable land and accessible fresh water are decreasing. This poses global challenges as economies continue to develop and the population grows. With agriculture as the leading consumer of water, better understanding how water is used to produce food may help support the increase of Crop Water Productivity (CWP; kg/m3), the ratio of crop output per unit of water input (or crop per drop). Previous large-scale CWP studies have been useful for broad water use modeling at coarser resolutions. However, obtaining more precise CWP, especially
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34

Romero, Matias, Shanti B. Penprase, Maximillian S. Van Wyk de Vries, et al. "Late Quaternary glacial maxima in southern Patagonia: insights from the Lago Argentino glacier lobe." Climate of the Past 20, no. 8 (2024): 1861–83. http://dx.doi.org/10.5194/cp-20-1861-2024.

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Abstract. Determining the timing and extent of Quaternary glaciations around the globe is critical to understanding the drivers behind climate change and glacier fluctuations. Evidence from the southern mid-latitudes indicates that local glacial maxima preceded the global Last Glacial Maximum (LGM), implying that feedbacks in the climate system or ice dynamics played a role beyond the underlying orbital forcings. To shed light on these processes, we investigated the glacial landforms shaped and deposited by the Lago Argentino glacier (50° S), an outlet lobe of the former Patagonian Ice Sheet,
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35

Stift, M. J., and F. Leone. "Zeeman Doppler mapping revisited: Force-free fields, regularisation functions, and abundance maps." Astronomy & Astrophysics 659 (March 2022): A33. http://dx.doi.org/10.1051/0004-6361/202142342.

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Aims. For the observational modelling of horizontal abundance distributions and of magnetic geometries in chemically peculiar (CP) stars, Zeeman Doppler mapping (ZDM) has become the method of choice. Comparisons between abundance maps obtained for CP stars and predictions from numerical simulations of atomic diffusion have always proved unsatisfactory. This study is intended to explore the reasons for the discrepancies. Methods. We cast a cold eye (evoking the epitaph on Nobel laureate W.B. Yeats’ gravestone: Cast a cold Eye / On Life, on Death. / Horseman, pass by) on essential assumptions un
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36

Shusterman, A., M. Munz, G. Richter, et al. "The PF4/PPBP/CXCL5 Gene Cluster Is Associated with Periodontitis." Journal of Dental Research 96, no. 8 (2017): 945–52. http://dx.doi.org/10.1177/0022034517706311.

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Periodontitis is a common dysbiotic inflammatory disease with an estimated heritability of 50%. Due to the limited sample size of available periodontitis cohorts and the underlying trait heterogeneity, genome-wide association studies (GWAS) of chronic periodontitis (CP) have been unsuccessful in discovering susceptibility factors. A strategy that combines agnostic GWAS with a well-powered candidate-gene approach has the potential to discover novel loci. We combined RNA-seq data from gingival tissues with quantitative trait loci (QTLs) that were identified in a F2-cross of mice resistant and su
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37

Zhang, Xu, Jihyun Song, Binal N. Shah, et al. "Hypoxic Response-Dependent Genetic Regulation Revealed By Allele-Specific Expression in Reticulocytes of Chuvash Polycythemia." Blood 130, Suppl_1 (2017): 926. http://dx.doi.org/10.1182/blood.v130.suppl_1.926.926.

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Abstract Homozygosity for the VHLR200W mutation in Chuvash polycythemia (CP) leads to decreased degradation of the α subunits of hypoxia inducible factor (HIF)-1 and HIF-2 by the hypomorphic variant of VHL, the principal negative regulator of HIFs. The constitutively activated HIFs directly regulate the transcription of a suite of hypoxic responsible genes, including the principal regulators of erythropoiesis, vessel development, and glycolytic metabolism, which further trigger a downstream cascade of gene expression. Besides these transcriptional factors, cis acting elements play an important
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38

Soverini, Simona, Sabrina Colarossi, Alessandra Gnani, et al. "Frequency, Distribution and Prognostic Value of ABL Kinase Domain (KD) Mutations in Different Subsets of Philadelphia-Positive (Ph+) Patients (Pts) Resistant to Imatinib (IM) by the Gimema Working Party on CML." Blood 106, no. 11 (2005): 435. http://dx.doi.org/10.1182/blood.v106.11.435.435.

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Abstract Using denaturing-high performance liquid chromatography and sequencing, we screened for ABL KD mutations 319 IM-resistant Ph+ pts. Median time between diagnosis and IM start at 400–600 mg/d was 40 (0–160) months. Median duration of IM was 27 (9–62) months. Evaluable pts were 256/319 (80%). At the time of analysis, 178/256 (70%) pts were in chronic phase (CP)(36 previously untreated, 142 post-IFN failure), 16 (6%) pts were in accelerated phase (AP), 26 (10%) pts were in myeloid blast crisis (myBC), 36 (14%) were in lymphoid blast crisis (lyBC) or had Ph+ acute lymphoblastic leukemia (A
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39

Jabbour, Elias, Hagop Kantarjian, Dan Jones, et al. "Long-Term Incidence and Outcome of BCR-ABL Mutations in Patients (pts) with Chronic Myeloid Leukemia (CML) Treated with Imatinib Mesylate - P-Loop Mutations Are Not Associated with Worse Outcome." Blood 104, no. 11 (2004): 1007. http://dx.doi.org/10.1182/blood.v104.11.1007.1007.

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Abstract Resistance to imatinib in CML may occur through mutations of the BCR-ABL kinase domain. We investigated the occurrence of mutations in 159 pts treated with imatinib by direct sequencing. Pts had been treated with imatinib for a median of 32 months (mo) (range, 4 to 60 mo). 52 mutations were identified in 49 (31%) pts: 3 pts had 2 different mutations; in 2 of them they appeared simultaneously. Mutations mapped to 23 different amino acid residues, with the most frequent locating to the P-loop (n=19; 39%), and the residues in imatinib binding pocket (n=12; 25%). The single most common mu
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40

Gionbelli, Mateus P., Thais C. Costa, Diana C. Cediel-Devia, Karolina B. Nascimento, Tathyane R. S. Gionbelli, and Marcio S. Duarte. "427 Impact of late gestation slow-release nitrogen-enriched diets on energy metabolism in calf skeletal muscle: A proteomic and transcriptomic approach." Journal of Animal Science 102, Supplement_3 (2024): 202–3. http://dx.doi.org/10.1093/jas/skae234.237.

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Abstract The current study aimed to determine the enriched biological processes, through proteomic and transcriptomic data, associated with maternal slow-release nitrogen diets received during late gestation and their effects on the skeletal muscle of offspring. From d 180 to d 268 of gestation, a total of 16 pregnant Brahman cows were divided into two groups: a control (CON, n = 12) low crude protein (CP) basal diet (6% of CP, ad libitum) plus mineral mixture (130 gּ cow-1ּ d-1), or the CON treatment supplemented with a slow-released N (SRN, n = 9) based protein concentrate supplement [40% CP
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41

Braumann, Sandra M., Joerg M. Schaefer, Stephanie M. Neuhuber, Christopher Lüthgens, Alan J. Hidy, and Markus Fiebig. "Early Holocene cold snaps and their expression in the moraine record of the eastern European Alps." Climate of the Past 17, no. 6 (2021): 2451–79. http://dx.doi.org/10.5194/cp-17-2451-2021.

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Abstract. Glaciers preserve climate variations in their geological and geomorphological records, which makes them prime candidates for climate reconstructions. Investigating the glacier–climate system over the past millennia is particularly relevant first because the amplitude and frequency of natural climate variability during the Holocene provides the climatic context against which modern, human-induced climate change must be assessed. Second, the transition from the last glacial to the current interglacial promises important insights into the climate system during warming, which is of parti
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42

Davino, Salvatore, Laura Miozzi, Stefano Panno, Luis Rubio, Mario Davino, and Gian Paolo Accotto. "Recombination profiles between Tomato yellow leaf curl virus and Tomato yellow leaf curl Sardinia virus in laboratory and field conditions: evolutionary and taxonomic implications." Journal of General Virology 93, no. 12 (2012): 2712–17. http://dx.doi.org/10.1099/vir.0.045773-0.

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Tomato yellow leaf curl Sardinia virus and Tomato yellow leaf curl virus have co-existed in Italian tomato crops since 2002 and have reached equilibrium, with plants hosting molecules of both species plus their recombinants being the most frequent case. Recombination events are studied in field samples, as well as in experimental co-infections, when recombinants were detected as early as 45 days following inoculation. In both conditions, recombination breakpoints were essentially absent in regions corresponding to ORFs V2, CP and C4, whereas density was highest in the 3′-terminal portion of OR
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43

Kaeda, Jaspal S., Christian Oberender, Daniel Neuman, et al. "Differential Expression of SHP-1 Levels in Chronic Phase and Advanced Disease CML and in AML Patients." Blood 120, no. 21 (2012): 1449. http://dx.doi.org/10.1182/blood.v120.21.1449.1449.

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Abstract Abstract 1449 Despite unprecedented success of tyrosine kinase inhibitors (TKI) in treating chronic myeloid leukaemia (CML) patients, optimum clinical management is still impeded by lack of reliable predictive and prognostic markers to identify those at risk of progression from chronic phase (CP) to advanced disease (AD), i.e. accelerated phase (AP) and blast crisis (BC). Significantly, SHP-1 (Src homology 2 domain-containing phosphates-1) is reported to bind to BCR-ABL1. Furthermore, SHP-1 knockout mice fail to thrive and develop a myeloproliferative-like disease, while point mutatio
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44

Bağrıaçık, Metin. "Representing discourse in clausal syntax." Journal of Greek Linguistics 17, no. 2 (2017): 141–89. http://dx.doi.org/10.1163/15699846-01702001.

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In Pharasiot Greek, an Asia Minor Greek dialect, a certain particle copied from Turkish, ki, is employed in a number of seemingly unrelated constructions. Close scrutiny, however, reveals that in each of these constructions, ki is employed as a device geared to influencing the interlocutor’s epistemic vigilance. Based on the Cartographic Approach which defends the syntactization of the interpretive domains, I propose that this unique semantics of ki should be represented in the clause structure. Following recent work which advocates the existence of a pragmatic field—Speech Act Phrase (SAP) in
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45

Bud, Eugen Silviu, Cristina Ioana Bică, Mariana Păcurar, et al. "Observational Study Regarding Possible Side Effects of Miniscrew-Assisted Rapid Palatal Expander (MARPE) with or without the Use of Corticopuncture Therapy." Biology 10, no. 3 (2021): 187. http://dx.doi.org/10.3390/biology10030187.

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The use of maxillary expanders has the effect of distancing the maxillary bones at the level of the median palatal suture. During maxillary expansion, the main resistance forces occur at the zygomatico-maxillary sutures, and not in the median palatal suture, which is the basic principle on which this method is based. In this observational study, we evaluated possible complications at the skeletal and dentoalveolar level after palatal split using miniscrew-assisted rapid palatal expansion (MARPE) associated or not with corticopuncture (CP) therapy. The study included 27 patients with maxillary
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46

Kaeda, Jaspal S., Ken I. Mills, Michael G. Kharas, et al. "Increased MSI2 expression Is Associated with Aggressive CML and AML." Blood 118, no. 21 (2011): 2516. http://dx.doi.org/10.1182/blood.v118.21.2516.2516.

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Abstract Abstract 2516 The events triggering arrested differentiation and a more aggressive disease in chronic myeloid leukaemia (CML) patients are unclear. Dysregulation of MSI2 has been suggested as a causal event in the transformation of chronic phase (CP), a relatively indolent disease phase, to blast crisis (BC), which is usually fatal. The Musashi gene family, regulated by HOXA9, has been shown to control critical cell fate decisions by binding to the 3'untranslated region of target mRNAs, thereby inhibiting translation. This results in dysfunction of the regulatory pathway, leading to h
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47

Ayllón, María A., Siddarame Gowda, Tatineni Satyanarayana, et al. "Effects of Modification of the Transcription Initiation Site Context on Citrus Tristeza Virus Subgenomic RNA Synthesis." Journal of Virology 77, no. 17 (2003): 9232–43. http://dx.doi.org/10.1128/jvi.77.17.9232-9243.2003.

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ABSTRACT Citrus tristeza virus (CTV), a member of the Closteroviridae, has a positive-sense RNA genome of about 20 kb organized into 12 open reading frames (ORFs). The last 10 ORFs are expressed through 3′-coterminal subgenomic RNAs (sgRNAs) regulated in both amounts and timing. Additionally, relatively large amounts of complementary sgRNAs are produced. We have been unable to determine whether these sgRNAs are produced by internal promotion from the full-length template minus strand or by transcription from the minus-stranded sgRNAs. Understanding the regulation of 10 sgRNAs is a conceptual c
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48

Zhou, Y. C., E. R. Garrido-Ramirez, M. R. Sudarshana, S. Yendluri, and R. L. Gilbertson. "The N-terminus of the Begomovirus Nuclear Shuttle Protein (BV1) Determines Virulence or Avirulence in Phaseolus vulgaris." Molecular Plant-Microbe Interactions® 20, no. 12 (2007): 1523–34. http://dx.doi.org/10.1094/mpmi-20-12-1523.

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The BV1 gene of the bipartite Begomovirus genome encodes a nuclear shuttle protein (NSP) that is also an avirulence determinant in common bean. The function of the NSP of two common bean-infecting bipartite begomoviruses, Bean dwarf mosaic virus (BDMV) and Bean golden yellow mosaic virus (BGYMV), was investigated using a series of hybrid DNA-B components expressing chimeric BDMV and BGYMV NSP, and genotypes of the two major common bean gene pools: Andean (cv. Topcrop) and Middle American (cvs. Alpine and UI 114). BDMV DNA-A coinoculated with HBDBG4 (BDMV DNA-B expressing the BGYMV NSP) and HBD
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49

Soverini, Simona, Luana Bavaro, Margherita Martelli, et al. "Compound BCR-ABL1 Kinase Domain Mutants: Prevalence, Spectrum and Correlation with Tyrosine Kinase Inhibitor Resistance in a Prospective Series of Philadelphia Chromosome-Positive Leukemia Patients Analyzed By Next Generation Sequencing." Blood 132, Supplement 1 (2018): 789. http://dx.doi.org/10.1182/blood-2018-99-117166.

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Abstract Next-Generation Sequencing (NGS)-based BCR-ABL1 kinase domain (KD) mutation screening has been shown to enable greater accuracy and sensitivity and straightforward identification of compound mutants (CM) as compared to Sanger sequencing (seq). However, the prevalence of CMs has never been assessed in prospective studies, and although in vitro data suggest that many of them may be challenging for all tyrosine kinase inhibitors (TKIs) including ponatinib, attempts to correlate such data with in vivo responses have never been made. To address these issues, we have reviewed the results of
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50

Kattoush, Abbas Hasan. "A Radon Slantlet Transforms Based OFDM System Design and Performance Simulation under Different Channel Conditions." ISRN Communications and Networking 2012 (March 8, 2012): 1–8. http://dx.doi.org/10.5402/2012/318921.

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Due to its good orthogonality, slantlet transform (SLT) is used in orthogonal frequency division multiplexing (OFDM) systems to reduce intersymbol interference (ISI) and intercarrier interference (ICI). This eliminates the need for cyclic prefix (CP) and increases the spectral efficiency of the design. Finite Radon transform (FRAT) mapper has the ability to increase orthogonality of subcarriers, is nonsensitive to channel parameters variations, and has a small constellation energy compared with conventional fast-Fourier-transform- (FFT-) based OFDM. It is also able to work as a good interleave
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