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Dissertations / Theses on the topic 'Mara Twp'

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Published: 4 June 2021

Last updated: 1 February 2022

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1

Vicente, José Manuel Ivo Carvalho. "A percepção do consumidor do valor da marca : O caso TAP Portugal." Master's thesis, Universidade de Évora, 2009. http://hdl.handle.net/10174/18704.

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Neste trabalho de investigação pretende-se responder à questão: qual a importância da percepção do consumidor do valor da marca TAP PORTUGAL? Para atingir os objectivos da investigação realizou-se um estudo de caso, tendo-se elaborado entrevistas junto de responsáveis pela área do marketing da companhia aérea nacional e procedeu-se à recolha de informação (publicações TAP, ANA¬ AEROPORTOS, entre outras; e, aplicou-se um questionário junto dos passageiros TAP. PORTUGAL no Aeroporto Internacional de Lisboa) de modo a se poder estudar o caso aprofundadamente. Os resultados da investigação indicam que a análise da nova imagem TAP PORTUGAL por parte dos passageiros é, de um modo geral, muito positiva, estando alinhados com os objectivos definidos no rebranding levado a cabo em 2005. A presente investigação contribui para sistematizar e clarificar as percepções dos consumidores do valor da marca TAP PORTUGAL, bem como retirar algumas ilações comparativas sobre os objectivos propostos e implementados na operação de rebranding com as percepções que os seus clientes têm desta nova imagem, contribuindo para uma melhor estratégia de gestão da marca. ABSTRACT; The present research seeks to answer the question: What is the importance of consumers' perception for the brand equity of TAP PORTUGAL? To achieve the objectives of the research a case study of methodology was done, having prepared interviews with the responsible for the marketing area of the Portuguese Airline, and proceeded to gather information (TAP, ANA-AEROPORTOS publications, among others; and, have applied a questionnaire to the TAP PORTUGAL passengers who made the check-in in the International Airport of Lisbon) to make a profound study of the case. Research results indicate that the new image analysis of TAP PORTUGAL from passengers, is generally very positive, and aligned with the objectives outlined in rebranding carried out in 2005. This research contributes to systematize and clarify the consumer's perceptions for the brand equity of TAP PORTUGAL, and draw some comparative conclusions on the objectives proposed and implemented in the rebranding operation with the customers’ perception that have the new image, contributing to improve the brand management strategy. NOTA: contém Cd em mau estado (Ilegível).

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2

Salgado, Camacho Ximena. "Diseño refrigerador top de línea con dispensadores marca FENSA." Tesis, Universidad de Chile, 2006. http://repositorio.uchile.cl/handle/2250/100978.

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El ánimo de esta memoria no es otro que mostrar la búsqueda de conceptos a partir de un requerimiento específico del gerente y la innovación como resultado de la investigación y desarrollo del diseño. Por otro lado estaría complacida si de alguna forma esta experiencia beneficia a los alumnos de la carrera en el sentido de conocer más cerca de la relación diseñador-empresa, la cual no conocerán hasta su práctica profesional.

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3

Pitzen, Simon Maria [Verfasser], Maria [Akademischer Betreuer] Kateri, and Udo [Akademischer Betreuer] Kamps. "Step-stress accelerated life testing with two stress factors / Simon Maria Pitzen ; Maria Kateri, Udo Kamps." Aachen : Universitätsbibliothek der RWTH Aachen, 2021. http://d-nb.info/1240904665/34.

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4

Lake, Kavan O. "Saving lives and money two wheels at a time." Thesis, Monterey, California : Naval Postgraduate School, 2010. http://edocs.nps.edu/npspubs/scholarly/theses/2010/Mar/10Mar%5FLake.pdf.

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Thesis (M.S. in Manpower Systems Analysis)--Naval Postgraduate School, March 2010.
Thesis Advisor: Henderson, David R. ; Hatch, William D. "March 2010." Author(s) subject terms: Motorcycle safety training, motorcycle accident, motorcycle fatality, motorcycle injury, motorcycle life insurance cost, motorcycle hospitalization cost, military occupational specialty cost. Includes bibliographical references (p. 69-70). Also available in print.

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Shane, Keith Dennis. "Habitat-use and emigration patterns of two top predators stocked in a large flood-control impoundment." The Ohio State University, 2018. http://rave.ohiolink.edu/etdc/view?acc_num=osu1542722595138777.

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6

Trog, Luisa Maria [Verfasser]. "Pathogenität von IgA-Autoantikörpern gegen Typ VII Kollagen / Luisa Maria Trog." Lübeck : Zentrale Hochschulbibliothek Lübeck, 2014. http://d-nb.info/1064115314/34.

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7

Dietrich, Marc [Verfasser]. "Hochleistungspulsrohrkühler vom Stirling-Typ für energietechnische Anwendungen der Hochtemperatursupraleitung / Marc Dietrich." Gießen : Universitätsbibliothek, 2016. http://d-nb.info/1099886732/34.

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8

Harris, Ryan J. "Optimization and statistical evaluation of GOES cloud-top properties for nowcasting lightning initiation." Thesis, Monterey, California : Naval Postgraduate School, 2010. http://edocs.nps.edu/npspubs/scholarly/theses/2010/Mar/10Mar%5FHarris.pdf.

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Thesis (M.S. in Meteorology)--Naval Postgraduate School, March 2010.
Thesis Advisor(s): Durkee, Philip A. Second Reader: Nielsen, Kurt E. "March 2010." Description based on title screen as viewed on April 27, 2010. Author(s) subject terms: Lightning, Thunderstorm, GOES, Geostationary, Satellite, Convection, Convective Initiation, Lightning Initiation, Nowcast, Applied Meteorology. Includes bibliographical references (p. 97-101). Also available in print.

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9

Perera, Cecilia Maria [Verfasser]. "Tierexperimentelle Untersuchungen zu Auslösefaktoren der Thrombotisch-thrombozytopenischen Purpura (TTP) / Cecilia Maria Perera." Mainz : Universitätsbibliothek der Johannes Gutenberg-Universität Mainz, 2020. http://d-nb.info/1223379442/34.

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10

Myers, Matthew K. "A tale of two countries why some British Muslims turned to terrorism and French Muslims did not." Thesis, Monterey, California : Naval Postgraduate School, 2010. http://edocs.nps.edu/npspubs/scholarly/theses/2010/Mar/10Mar%5FMyers.pdf.

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Thesis (M.A. in Security Studies (Homeland Security and Defense))--Naval Postgraduate School, March 2010.
Thesis Advisor(s): Hafez, Mohammed ; Siegel, Scott. "March 2010." Description based on title screen as viewed on April 23, 2010. Author(s) subject terms: Terrorism, Radicalization, Britain, France, Social Movement Theory Includes bibliographical references (p. 73-79). Also available in print.

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11

Feldmaier, Teresa [Verfasser], and Maria [Akademischer Betreuer] Daghofer. "Excitonic antiferromagnetism in two-dimensional t4 2g systems / Teresa Feldmaier ; Betreuer: Maria Daghofer." Stuttgart : Universitätsbibliothek der Universität Stuttgart, 2020. http://d-nb.info/120406122X/34.

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12

Kanneganti, Raghuveer. "CLASSIFICATION OF ONE-DIMENSIONAL AND TWO-DIMENSIONAL SIGNALS." OpenSIUC, 2014. https://opensiuc.lib.siu.edu/dissertations/892.

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This dissertation focuses on the classification of one-dimensional and two-dimensional signals. The one-dimensional signal classification problem involves the classification of brain signals for identifying the emotional responses of human subjects under given drug conditions. A strategy is developed to accurately classify ERPs in order to identify human emotions based on brain reactivity to emotional, neutral, and cigarette-related stimuli in smokers. A multichannel spatio-temporal model is employed to overcome the curse of dimensionality that plagues the design of parametric multivariate classifiers for multi-channel ERPs. The strategy is tested on the ERPs of 156 smokers who participated in a smoking cessation program. One half of the subjects were given nicotine patches and the other half were given placebo patches. ERPs were collected from 29 channel in response to the presentation of the pictures with emotional (pleasant and unpleasant), neutral/boring, and cigarette-related content. It is shown that human emotions can be classified accurately and the results also show that smoking cessation causes a drop in the classification accuracies of emotions in the placebo group, but not in the nicotine patch group. Given that individual brain patterns were compared with group average brain patterns, the findings support the view that individuals tend to have similar brain reactions to different types of emotional stimuli. Overall, this new classification approach to identify differential brain responses to different emotional types could lead to new knowledge concerning brain mechanisms associated with emotions common to most or all people. This novel classification technique for identifying emotions in the present study suggests that smoking cessation without nicotine replacement results in poorer differentiation of brain responses to different emotional stimuli. Future, directions in this area would be to use these methods to assess individual differences in responses to emotional stimuli and to different drug treatments. Advantages of this and other brain-based assessment include temporal precision (e.g, 400-800 ms post stimulus), and the elimination of biases related to self-report measures. The two-dimensional signal classification problems include the detection of graphite in testing documents and the detection of fraudulent bubbles in test sheets. A strategy is developed to detect graphite responses in optical mark recognition (OMR) documents using inexpensive visible light scanners. The main challenge in the formulation of the strategy is that the detection should be invariant to the numerous background colors and artwork in typical optical mark recognition documents. A test document is modeled as a superposition of a graphite response image and a background image. The background image in turn is modeled as superposition of screening artwork, lines, and machine text components. A sequence of image processing operations and a pattern recognition algorithm are developed to estimate the graphite response image from a test document by systematically removing the components of the background image. The proposed strategy is tested on a wide range of scanned documents and it is shown that the estimated graphite response images are visually similar to those scanned by very expensive infra-red scanners currently employed for optical mark recognition. The robustness of the detection strategy is also demonstrated by testing a large number of simulated test documents. A procedure is also developed to autonomously determine if cheating has occurred by detecting the presence of aberrant responses in scanned OMR test books. The challenges introduced by the significant imbalance in the numbers of typical and aberrant bubbles were identified. The aberrant bubble detection problem is formulated as an outlier detection problem. A feature based outlier detection procedure in conjunction with a one-class SVM classifier is developed. A multi-criteria rank-of-rank-sum technique is introduced to rank and select a subset of features from a pool of candidate features. Using the data set of 11 individuals, it is shown that a detection accuracy of over 90% is possible. Experiments conducted on three real test books flagged for suspected cheating showed that the proposed strategy has the potential to be deployed in practice.

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13

Blumenau, Marc [Verfasser]. "Schmelztauchveredelung von hochmanganlegiertem TWIP-Stahl unter Berücksichtigung der wasserstoffinduzierten Rissbildung nach Umformen / Marc Blumenau." Aachen : Shaker, 2010. http://d-nb.info/1084536412/34.

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14

Eckart, Maria [Verfasser]. "Klinische Langzeitbeobachtung von Patienten mit spinaler Muskelatrophie und Atemnot Typ 1 (SMARD1) / Maria Eckart." Berlin : Medizinische Fakultät Charité - Universitätsmedizin Berlin, 2012. http://d-nb.info/1027306942/34.

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15

Tozzo, Laura [Verfasser], Mathias [Akademischer Betreuer] Schulze, and Maria Evelina [Akademischer Betreuer] Rossi. "Two instances of duality in commutative algebra / Laura Tozzo ; Mathias Schulze, Maria Evelina Rossi." Kaiserslautern : Technische Universität Kaiserslautern, 2017. http://d-nb.info/1149512822/34.

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16

Buchtelová, Miroslava. "Cenová mapa nájemného bytů v Brně." Master's thesis, Vysoké učení technické v Brně. Fakulta stavební, 2012. http://www.nusl.cz/ntk/nusl-225387.

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The aim of the thesis is to create price maps of rental flats in Brno . This maps are elaborated in graphical and electronical form. There is also description of obatining and evaluating of data concerning rents of flats. Data are membered according to the type of flat and city parts of Brno. Analysis of data is a part of the thesis as well.

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17

Murray, Lauren Baker. "The Nineteenth Century Oboe Concertino: An Overview of its Structure with Two Performance Guides." Thesis, view full-text document, 2002. http://www.library.unt.edu/theses/open/20022/murray%5Flauren%5Fbaker/index.htm.

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18

Tatjer, i. Montaña Joan Carles. "Invariant manifolds and bifurcations for one-dimensional and two-dimensional dissipative maps." Doctoral thesis, Universitat de Barcelona, 1990. http://hdl.handle.net/10803/2113.

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It is known that for the study of continuous dynamical systems the discret case plays an important role because, with it we can study the continuous one by using the Poincaré return map. In the discret case we can distinguish between conservative maps (or area preserving maps, in the case of flows living on a 3-dimensional manifold) and non conservative maps. Among the last ones, there are the dissipative maps. Two of the main subjects of the study of dissipative maps are: the existence or not of attracting periodic orbits and the possible existence of strange attractors -that is, attractors that are neither periodic orbits nor invariant curves, which are minimal and contain a dense orbit. Moreover, these attractors can have sensitive dependence on the initial conditions, or have an absolutely continuous invariant measure. On the other hand there exists a transition between these two behaviours: the so-called flip or period doubling bifurcation cascade. After the final of this cascade (in a suitable set of parameters), strange attractors can appear, and also more attracting periodic orbits.

This doctoral dissertation is divided in four chapters:

In the first one we study the dynamics of the so called logistic map; more specifically, we study first fold and flip bifurcations of this family, giving analytical expressions of the parameter values for which they occur. In the second chapter, we consider the Hénon map with strong dissipation. In the third chapter we study the Newhouse phenomenon. To this end we prove a more complete version of the phenomenon than others proved before, in which we show the existence of generic saddle-node and flip bifurcations, for parameters close to the parameter of homoclinic tangency. In chapter four we study the behaviour of the codimension one and two bifurcations in one and two dimensional families of maps. To do this, we consider one-parameter families of diffeomorphisms, to study saddle-node and flip bifurcations, and two-parameter families of dissipative diffeomorphisms, to study cusps and codimension two flips.

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19

Padilla, Maturana Eric Nibaldo. "“Diseño de un Sistema de Control de Gestión Bajo el Concepto y Metodología de un “Cuadro de Mando Integral (CMI)”, para la Empresa Tecno Tip-Top (Chile) S.A. Sucursal Iquique." Tesis, Universidad de Chile, 2008. http://www.repositorio.uchile.cl/handle/2250/101948.

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20

Dahmen, Maria [Verfasser]. "Structural and biochemical characterization of the two Caseinolytic Protease Complexes (ClpXP) of Listeria monocytogenes / Maria Dahmen." München : Verlag Dr. Hut, 2016. http://d-nb.info/1084386372/34.

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21

Negretti, Maria Eletta [Verfasser]. "Hydrodynamic instabilities and entrainment in two-layer stratified flows down a slope / von Maria Eletta Negretti." Karlsruhe : Univ.-Verl. Karlsruhe, 2007. http://d-nb.info/985610263/34.

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22

Li, Xinye [Verfasser], Christof [Akademischer Betreuer] Melcher, Stephen [Akademischer Betreuer] Gustafson, and Maria Gabrielle [Akademischer Betreuer] Westdickenberg. "Topological solitons in two-dimensional chiral magnets / Xinye Li ; Christof Melcher, Stephen Gustafson, Maria Gabrielle Westdickenberg." Aachen : Universitätsbibliothek der RWTH Aachen, 2020. http://d-nb.info/1227992599/34.

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23

Suriano, Valeria. ""Love you two" di Maria Pallotta-Chiarolli: Tradurre un romanzo Young Adult di un'autrice italo-australiana." Master's thesis, Alma Mater Studiorum - Università di Bologna, 2015. http://amslaurea.unibo.it/9483/.

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Lo scopo di questa Tesi di Laurea è quello di offrire una proposta di traduzione in italiano del romanzo LGBTQ per Young Adults Love You Two, di Maria Pallotta-Chiarolli. Quest'opera esplora temi delicati, come la bisessualità e il poliamore, dal punto di vista di una adolescente che scopre la propria identità e quella della sua famiglia italo-australiana. Questo studio fornisce inoltre una panoramica del contesto socio-culturale e letterario in cui il romanzo è stato pubblicato. Oltre ad esaminare le caratteristiche del libro, come genere letterario e tipologia, intenzionalità dell'autore, tematiche, funzione, stile e pubblico, si offre un'analisi dettagliata della strategia applicata nel processo traduttivo, che tende a conferire al testo un leggero effetto straniante, tale da evidenziarne le specificità culturale. La presente ricerca è stata condotta in parte in Australia presso la University of Melbourne e la Deakin University e si configura come un tentativo di mostrare la necessità e la possibilità di tradurre e pubblicare letteratura LGBT per ragazzi e ragazze in Italia.

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Cahill, Kathleen M. "Ave Maria and Celebration an examination of the visionary influences on the design and development of two new town intentional communities in the state of Florida /." Connect to this title, 2008. http://scholarworks.umass.edu/theses/140/.

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McMullen, Joshua James. "Under the big top Maria B. Woodworth, experiential religion and big tent revivalism in late nineteenth century Saint Louis /." Diss., Columbia, Mo. : University of Missouri-Columbia, 2007. http://hdl.handle.net/10355/6040.

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Thesis (M.A.)--University of Missouri-Columbia, 2007.
The entire dissertation/thesis text is included in the research.pdf file; the official abstract appears in the short.pdf file (which also appears in the research.pdf); a non-technical general description, or public abstract, appears in the public.pdf file. Title from title screen of research.pdf file (viewed on April 16, 2009) Includes bibliographical references.

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Lampila, S. (Satu). "The causes and consequences of population declines of two boreal forest species:the case of the willow tit (Parus montanus) and the Siberian flying squirrel (Pteromys volans)." Doctoral thesis, University of Oulu, 2009. http://urn.fi/urn:isbn:9789514290718.

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Abstract I used individual-based capture-mark-recapture data and genetic markers to gain understanding of the demographic and genetic processes operating in small and declining populations of two different species, the willow tit Parus montanus and the Siberian flying squirrel Pteromys volans. Both species have declined in Finland and the flying squirrel has been considered to be vulnerable. The willow tit study was conducted in northern Finland, near city of Oulu. The population size in the studied area has on average been stable during the past decade. Adult survival in the willow tit was high and fairly stable and was positively correlated with recruitment. Adult survival has been the most influential vital rate to the population growth rate. Local recruitment and immigration have high variation, inducing variation in the population growth rate. Female willow tits use extrapair copulations to maximise offspring heterozygosity. Heterozygous individuals are supposedly of higher quality than homozygous ones. I found weak negative association between individual homozygosity and recruitment probability. The flying squirrel populations have declined during the past ten years. Furthermore, adult survival has declined in one of the populations, most likely due to habitat loss and fragmentation that decrease the adult survival and limit dispersal. The flying squirrel populations were studied in western Finland. The flying squirrel densities in the studied areas are the highest in Finland and therefore these areas have been regarded as favourable for the flying squirrel. My results question this view. Microsatellite analyses strengthen the view of populations doing poorly, because the heterozygosities in all the populations and particularly in the most isolated one were rather low. High FST values indicate low dispersal even between adjacent populations. Following work should investigate the spatial variation in individual performance and the dispersal processes in these populations. For the flying squirrel it is vital to determine the size and quality of the patches that can support flying squirrels and the ones that apparently can not. Present estimates of survival and genetic diversity can be used to reconstruct a meaningful PVA and projections for these populations.

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Grahl, Mara [Verfasser], Dirk-Hermann [Akademischer Betreuer] Rischke, and Bengt [Akademischer Betreuer] Friman. "Low-energy effective models for two-flavor quantum chromodynamics and the universality hypothesis / Mara Grahl. Gutachter: Dirk-Hermann Rischke ; Bengt Friman. Betreuer: Dirk-Hermann Rischke." Frankfurt am Main : Univ.-Bibliothek Frankfurt am Main, 2014. http://d-nb.info/105184844X/34.

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Kawamoto, Hideko. "Summer Rain Part I Summer Rain - Dawn for Two-channel Tape; Part II After the Summer Rain for Piano and Two-channel Tape." Thesis, University of North Texas, 2001. https://digital.library.unt.edu/ark:/67531/metadc3010/.

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This dissertation contains five chapters: 1. Introduction, 2. Basic Digital Processing Used in Summer Rain, 3. Part I Summer Rain - Dawn, 4. Part II After the Summer Rain and 5. Conclusion. Introduction contains a brief historical background of musique concrète, Electronische Musik, acousmatic music and music for instruments and tape, followed by basic descriptions of digital technique used in both parts of Summer Rain in Chapter 2. Also Chapter 2 describes software used in Summer Rain including "Kawamoto's VST," which is based on MAX/MSP, to create new sounds from the recorded samples using a Macintosh computer. In both Chapter 3 and 4, Kawamoto discusses a great deal of the pre-compositional stage of each piece including inspirational sources, especially Rainer Maria Rilke's poems and Olidon Redon's paintings, as well as her visual and sound imageries. In addition Chapter 3 she talks about sound sources, pitch, form and soundscape. Chapter 4 contains analysis on pitch in the piano part, rhythm, form and the general performance practice. Chapter 5 is a short conclusion of her aesthetics regarding Summer Rain, which is connected to literature, visual art and her Japanese cultural background.

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Schweneker, Marc [Verfasser]. "Identification and characterization of two novel proteins interacting with the chemokine- and HIV-1 co-receptor CCR5 / Marc Schweneker." Berlin : Freie Universität Berlin, 2017. http://d-nb.info/114004351X/34.

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Apostolopoulou, Maria Verfasser], Michael [Gutachter] [Roden, and Stephan vom [Gutachter] Dahl. "Einflussfaktoren auf die Insulinsensitivität in Adipositas und Diabetes mellitus Typ 2 / Maria Apostolopoulou ; Gutachter: Michael Roden, Stephan vom Dahl." Düsseldorf : Universitäts- und Landesbibliothek der Heinrich-Heine-Universität Düsseldorf, 2018. http://d-nb.info/1169911250/34.

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Schludi, Verena Maria [Verfasser], and Christian [Akademischer Betreuer] Wahl-Schott. "Physiologische Funktion und pathophysiologische Relevanz des Zwei-Poren-Kanals Typ 2 (TPC2) / Verena Maria Schludi ; Betreuer: Christian Wahl-Schott." München : Universitätsbibliothek der Ludwig-Maximilians-Universität, 2018. http://d-nb.info/1179076001/34.

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Vondracek, Elena Maria [Verfasser], and Stephan [Akademischer Betreuer] Jacob. "Kardiometabolisches Risikomanagement bei Patienten mit Diabetes mellitus Typ 2 in der aktuellen Versorgung / Elena Maria Vondracek ; Betreuer: Stephan Jacob." Tübingen : Universitätsbibliothek Tübingen, 2015. http://d-nb.info/1163664642/34.

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Kashiotis, Anna-Maria [Verfasser]. "Zur funktionellen Rolle von A-Typ Kaliumkanälen und deren β-Untereinheit KChIP4 in dopaminergen Mittelhirnneuronen der Maus / Anna-Maria Kashiotis." Frankfurt am Main : Univ.-Bibliothek Frankfurt am Main, 2015. http://d-nb.info/1079361952/34.

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Groß, Claudia Maria [Verfasser], Wolfgang [Akademischer Betreuer] Wurst, and Johannes [Akademischer Betreuer] Beckers. "Expression, Regulation und Funktion von Tdp-43 in der Maus / Claudia Maria Groß. Gutachter: Wolfgang Wurst ; Johannes Beckers. Betreuer: Wolfgang Wurst." München : Universitätsbibliothek der TU München, 2011. http://d-nb.info/1013437039/34.

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Dantscher, Kathrin-Maria [Verfasser], and Sergey D. [Akademischer Betreuer] Ganichev. "Terahertz Laser Spectroscopy of Two- and Three-Dimensional Topological Insulators based on HgTe Nanostructures / Kathrin-Maria Dantscher ; Betreuer: Sergey D. Ganichev." Regensburg : Universitätsbibliothek Regensburg, 2017. http://d-nb.info/1149366656/34.

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Pultz, Brunna dos Anjos. "Investigação dos níveis séricos de EGFR1, HER-2, TSP-1 e RANKL em pacientes com câncer de mama inicial e avançado." Universidade Federal de Uberlândia, 2015. https://repositorio.ufu.br/handle/123456789/16714.

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Breast cancer is the most common malignancy among women and represents a serious health problem around the world. Despite of the progression in cancer research, there is a few biomarker validated to be used in clinical routine. Thus, this work aimed to investigate the levels of four serum proteins related with the mostly earlier events of breast cancer. For this purpose, serum levels of EGFR1, HER-2, TSP-1 and RANKL were investigated in twenty-eight patients with breast cancer in the early and advanced stage by ELISA method. Nineteen volunteers with no breast cancer were included in this study as controls. The results showed that serum EGFR1 (sEGFR1) levels decrease with disease progression. The mean sEGFR1 concentration in control group was 61.7 ng/mL, 38.0 ng/mL in initial breast cancer and 34.2 ng/mL in metastatic breast cancer. The best cutoff value was 46.85 ng/mL, it was able to distinguish volunteers and breast cancer patients with 75% sensitivity, and 94.7% specificity. Regarding sHER-2, its levels were found to increase with disease progression. Serum HER-2 (sHER-2) median in control group was 5.13 ng/mL, and in initial breast, and metastatic breast cancer women the mean was 5.99 ng/mL and 6.18 ng/mL, respectively. A cutoff value of 5.38 ng/mL of HER-2 was able to distinguish healthy and breast cancer individuals with 81.5% of sensitivity and 78.9% of specificity. Regarding TSP-1, women with metastatic breast cancer had significantly lower levels than control group and initial breast cancer. Besides although initial patients tend to have a higher concentration than control group, no statistical difference was observed. Concerning serum RANKL no differences was observed between the groups. In conclusion, our results bring evidence that sEGFR1 and sHER-2 should be investigated in a large clinical trial in an attempt to validate these proteins as potentials biomarkers for earlier detection of breast cancer.
O câncer de mama é a neoplasia maligna mais comum entre as mulheres e representa um sério problema de saúde pública em todo o mundo. Apesar dos avanços em pesquisas na área de cancerologia, há poucos biomarcadores validados para uso na rotina clínica. Assim, este trabalho teve como objetivo investigar os níveis de quatro proteínas do soro relacionadas com os eventos em sua maioria anteriores do câncer de mama. Para este efeito, os níveis séricos de EGFR1, HER-2, TSP-1 e RANKL foram investigados em vinte e oito pacientes com câncer de mama em estádio inicial e avançado, pelo método de ELISA. Dezenove voluntárias sem câncer de mama foram incluídas neste estudo como grupo controle. Os resultados mostraram que os níveis séricos de EGFR1 (sEGFR1) diminui com a progressão da doença. A concentração média de sEGFR1 no grupo controle foi de 61,7 ng/mL, 38,0 ng/mL no câncer de mama inicial e 34,2 ng/mL no câncer de mama metastático. O melhor valor de cutoff foi 46,85 ng/mL, com sensibilidade de 75% e 94,7% de especificidade para distinguir entre pacientes com câncer de mama e grupo controle. Com relação ao sHER-2, as concentrações foram encontradas para aumentar com a progressão da doença. A concentração mediana de sHER-2 no grupo de controle foi de 5,13 ng/mL, e em pacientes com a neoplasia em sua fase inicial e com câncer de mama metastático a mediana foi de 5,99 ng/mL e 6,18 ng/mL, respectivamente. Um valor de cutoff de 5,38 ng/mL de HER-2 foi capaz de distinguir indivíduos saudáveis e de câncer de mama, com 81,5% de sensibilidade e 78,9% de especificidade. Quanto à sTSP-1, mulheres com câncer de mama metastático têm níveis mais baixos do que o grupo controle e pacientes com câncer inicial. Além disso, embora as pacientes iniciais tendessem a ter uma concentração mais elevada do que o grupo controle, não houve diferença estatística. Quanto ao sRANKL nenhuma diferença foi observada entre os grupos. Por último, os nossos resultados trazem evidências de que os níveis de sEGFR1 e sHER-2 devem ser investigados em ensaios clínicos com tamanho amostral significativo na tentativa de se validar estas proteínas como potenciais biomarcadores para a detecção precoce do câncer de mama.
Mestre em Imunologia e Parasitologia Aplicadas

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Graf, Saskia Barbara Anni Irmgard [Verfasser], Dieter [Akademischer Betreuer] Neumeier, Petra-Maria Akademischer Betreuer] Schumm-Draeger, and Johann Josef [Akademischer Betreuer] [Hauner. "Untersuchung zum Einfluss der Höhe auf die Blutzuckerhomöostase bei Patienten mit Diabetes mellitus Typ 1 unter körperlicher Belastung / Saskia Graf. Gutachter: Dieter Neumeier ; Petra-Maria Schumm-Draeger ; Johann J. Hauner. Betreuer: Petra-Maria Schumm-Draeger." München : Universitätsbibliothek der TU München, 2011. http://d-nb.info/1014330289/34.

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Keppel, Marc [Verfasser], Julia [Gutachter] Frunzke, and Georg [Gutachter] Groth. "Network architecture and heme-responsive gene regulation of the two-component systems HrrSA and ChrSA / Marc Keppel ; Gutachter: Julia Frunzke, Georg Groth." Düsseldorf : Universitäts- und Landesbibliothek der Heinrich-Heine-Universität Düsseldorf, 2019. http://d-nb.info/1176806688/34.

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Rösmann, Katharina Maria [Verfasser], and Helge [Akademischer Betreuer] Karch. "Charakterisierung der Typ-1-Fimbrien-Expression bei HUS-assoziierten enterohämorrhagischen Escherichia coli (EHEC) : Charakterisierung der Typ 1 Fimbrien-Expression bei HUS-assoziierten enterohämorrhagischen Escherichia coli (EHEC) / Katharina Maria Rösmann. Betreuer: Helge Karch." Münster : Universitäts- und Landesbibliothek der Westfälischen Wilhelms-Universität, 2011. http://d-nb.info/1017643377/34.

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Schipper, Marc [Verfasser], Manfred [Akademischer Betreuer] Fahle, and Udo [Akademischer Betreuer] Ernst. "Über die Abhängigkeit lokaler Konturintegration von Bottom-up-, Top-down- und globalen Gestaltprozessen / Marc Schipper. Gutachter: Manfred Fahle ; Udo Ernst. Betreuer: Manfred Fahle." Bremen : Staats- und Universitätsbibliothek Bremen, 2011. http://d-nb.info/1071993453/34.

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Negretti, Maria Eletta [Verfasser], and G. H. [Akademischer Betreuer] Jirka. "Hydrodynamic instabilities and entrainment processes in two-layer density-stratified exchange flows over a submerged sill / Maria Eletta Negretti ; Betreuer: G. H. Jirka." Karlsruhe : KIT-Bibliothek, 2007. http://d-nb.info/1186011254/34.

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Edalat, Lena Maria [Verfasser], and Peter [Akademischer Betreuer] Ruth. "Calcium-aktivierte Kaliumkanäle vom BK Ca- und IK Ca-Typ regulieren radioinduzierte Migration sowie Radiosensitivität von Glioblastomzellen / Lena Maria Edalat ; Betreuer: Peter Ruth." Tübingen : Universitätsbibliothek Tübingen, 2016. http://d-nb.info/1164168223/34.

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Edalat, Lena [Verfasser], and Peter [Akademischer Betreuer] Ruth. "Calcium-aktivierte Kaliumkanäle vom BK Ca- und IK Ca-Typ regulieren radioinduzierte Migration sowie Radiosensitivität von Glioblastomzellen / Lena Maria Edalat ; Betreuer: Peter Ruth." Tübingen : Universitätsbibliothek Tübingen, 2016. http://d-nb.info/1164168223/34.

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Herzfeld, Eva-Maria [Verfasser], Ulla [Akademischer Betreuer] Bonas, Ingo [Akademischer Betreuer] Heilmann, and Rüdiger [Akademischer Betreuer] Hell. "Identifizierung und Charakterisierung von dem pflanzlichen Interaktionspartner OAS-TL des Typ-III-Effektors XopC / Eva-Maria Herzfeld. Betreuer: Ulla Bonas ; Ingo Heilmann ; Rüdiger Hell." Halle, Saale : Universitäts- und Landesbibliothek Sachsen-Anhalt, 2013. http://d-nb.info/1035182203/34.

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Grüber, Lena Maria [Verfasser], Juris [Gutachter] Meier, and Matthias Wolfgang [Gutachter] Banasch. "Pulsatile Insulinsekretion bei Patienten mit Typ 2-Diabetes mellitus im Vergleich zu einer Kontrollgruppe / Lena Maria Grüber ; Gutachter: Juris Meier, Matthias Wolfgang Banasch ; Medizinische Fakultät." Bochum : Ruhr-Universität Bochum, 2018. http://d-nb.info/1173421297/34.

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Vries, Maria de [Verfasser], Michael [Akademischer Betreuer] Schloter, Wolfgang [Gutachter] Liebl, and Michael [Gutachter] Schloter. "Functional and phylogenetic diversity of cellulase genes in agricultural soil under two different tillage treatments / Maria de Vries ; Gutachter: Wolfgang Liebl, Michael Schloter ; Betreuer: Michael Schloter." München : Universitätsbibliothek der TU München, 2018. http://d-nb.info/1168380383/34.

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Kirchner, Eva-Maria [Verfasser], and Antje J. [Akademischer Betreuer] Bäumner. "Electroanalysis and Raman Spectroscopy of Graphene-Modified Electrodes Influenced by the Synthesis and Transfer of the Two-Dimensional Nanomaterial / Eva-Maria Kirchner ; Betreuer: Antje J. Bäumner." Regensburg : Universitätsbibliothek Regensburg, 2021. http://d-nb.info/1237884764/34.

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Navalles, Villar Pere. "Sobre la capacitat de reconeixement i identificació d’una marca comercial, per mitjà de l’olfacte. Memòria olfactiva. Top ten de marques per la seva capacitat de recordacció olfactiva." Doctoral thesis, Universitat Autònoma de Barcelona, 2012. http://hdl.handle.net/10803/96427.

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Kühl, Rea Maria [Verfasser], and Gerhard [Akademischer Betreuer] Huber. "Improving exercise prescriptions for hematological cancer patients during and after allogeneic stem cell transplantation. Conclusions from two large randomized controlled trials / Rea Maria Kühl ; Betreuer: Gerhard Huber." Heidelberg : Universitätsbibliothek Heidelberg, 2016. http://d-nb.info/1180614925/34.

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Pöhnl, Katharina Maria [Verfasser], Volker [Akademischer Betreuer] Schusdziarra, and Roland M. [Akademischer Betreuer] Schmid. "Untersuchungen der basalen und postprandialen Insulinsekretion und -clearance bei adipösen Typ 2-Diabetikern / Katharina Maria Pöhnl. Gutachter: Roland M. Schmid ; Volker Heinrich Schusdziarra. Betreuer: Volker Heinrich Schusdziarra." München : Universitätsbibliothek der TU München, 2014. http://d-nb.info/1049523601/34.

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