Journal articles on the topic 'Marcin (17 w.)'

Artykuł przedstawia <em>Dzieje tureckie </em>Marcina Paszkowskiego jako dzieło encyklopedyczne i relację pamiętnikarską, ale przede wszystkim jako poemat epicki, zawierający interesującą, dramatyczną opowieść fabularną o losach Jakuba Kimikowskiego, obywatela Rzeczypospolitej 17 w. &ndash; przeciętnego reprezentanta &oacute;wczesnego stanu szlacheckiego zmagającego się z trudami i przeciwnościami niewoli turecko-tatarskiej.

Parafia Świętych Apostołów Piotra i Pawła w Spring Valley, Ill., została założona 30 września 1891 r., a nowo wybudowany drewniany kościół został poświęcony 14 sierpnia 1892 r. Na początku do tej parafii należało około 200 rodzin Polaków i Litwinów. Po kilku latach Litwini wznieśli własny kościół. W 1901 r. Polacy wybudowali szkołę i plebanię. 17 grudnia 1906 r. pożar doszczętnie zniszczył świątynię. Ocalała plebania i szkoła. Przez rok nabożeństwa odprawiano w prywatnym budynku. Budowę nowego murowanego kościoła rozpoczęto w 1908 r., jego budowniczy, ks. Hieronim W. Błażyński złożony chorobą zmarł tego samego roku. Od 13 marca 1909 r. budowę kontynuował ks. Józef Cieśla. W krótkim czasie zdołał świątynię dokończyć i wyposażyć ołtarzami, ozdobić witrażami i zapełnić ławkami na pięćset miejsc. Poświęcenie nowego kościoła odbyło się 29 czerwca 1909 r. Przy parafii prowadzona była szkoła, w której blisko 200 dzieci uczyły siostry franciszkanki. Konsekracja kościoła miała miejsce 31 maja 1920 r.&#x0D; W tym okresie w parafii pracowali księża: Sikorski, Wałajtys, Łopata, Tonello, Mączyński i Balcewicz. Pierwszym proboszczem, od roku 1894 był ks. Julian Papoń, następnie od 1897 r. – ks. Michał Peża, od 1900 r. – ks. Antoni Drewnicki, od 1903 r. – ks. Marcin Piechota, od 1908 r. – ks. Hieronim Błażyński i od 1909 r. – ks. Józef Cieśla.

Artykuł powstał na podstawie Kroniki Sióstr Bernardynek z Lublina, przechowywanej w Bibliotece Wyższego Seminarium Duchownego w Sandomierzu. Kronika została przywieziona do Sandomierza w 1912 r. przez regenta seminarium, księdza Kubickiego. Przekazała mu ją Klara Gano, ostatnia przełożona klasztoru bernardynek w Lublinie. Prace nad historią klasztoru rozpoczęto w drugiej połowie XVIII w., a zakończono w latach następnych, kiedy to dodano najważniejsze wydarzenia. W ten sposób powstało dzieło o dziejach klasztoru od jego początków w 1618 roku do likwidacji, która nastąpiła około 1885 roku.Fundatorami klasztoru byli Marcin Sienieński z żoną oraz Piotr Czerny. Przekazali oni zakonnicom dwa domy, drewnianą kaplicę, a w Rozkopaczôw kawałek ziemi na ich potrzeby. Klasztor powstał na miejscu dawnej wspólnoty zakonnej tercjarek bernardyńskich, istniejącej przed 1535 r. i do pożaru w 1580 roku. Budowa kościoła św. Piotra została rozpoczęta w 1636 roku przez siostrę przełożoną Mariannę Kochanowską, a jego konsekracja miała miejsce w 1658 roku. W kolejnych latach upiększano wnętrze kościoła i przeprowadzano dalsze remonty. W 1768 r. pożar spowodował tak rozległe zniszczenia, że pierwszą mszę można było odprawić dopiero w 1780 r., po odbudowie kościoła. Kolejna kompleksowa renowacja miała miejsce w latach 1873-1875. Budynki klasztorne pierwotnie składały się z dwóch domów, które były powiększane i modernizowane w trakcie istnienia wspólnoty klasztornej. Zakonnice posiadały grunty w Rozkopaczowie, Bystrzejowicach i Oleśnikach, które użytkowały lub dzierżawiły. Nieruchomości te były przedmiotem postępowań sądowych wszczynanych przez osoby chcące odebrać zakonnicom ich własność. Wyroki zapadające w tych procesach były na ogół korzystne dla zakonnic, z wyjątkiem prawa supresyjnego, które prowadziło do przejęcia majątku przez Skarb Państwa.Klasztorem założycielskim klasztoru lubelskiego był klasztor bernardynek św. Agnieszki w Krakowie. Na czele zgromadzenia stała siostra przełożona wybierana co trzy lata. Kronika odnotowuje 81 wyborów. U jej boku znajdowali się przedstawiciele zakonni, z których najważniejszymi byli jej asystent - wikariusz, następnie mistrzyni życia duchowego, mistrzyni świeckich dziewcząt, portier, zakrystian i siostra odpowiedzialna za refektarz lub szatnie. W ciągu 267 lat istnienia klasztoru mieszkało w nim 181 nowicjuszek i mniszek. Przedział wiekowy nowicjuszek wynosił od 17 lat i 10 miesięcy do 26 lat i 7 miesięcy, co daje średnio 21 lat i 2 miesiące w badanym okresie. Średnia długość życia zakonnic wynosiła 56 lat i 4 miesiące, czyli 34 lata i 8 miesięcy w klasztorze.Kronika jest cennym źródłem informacji o dziejach bernardynek w Lublinie. Zapoczątkowane na ten temat dyskusje zaowocują zapewne dalszymi badaniami i pracami nad dziejami tego zgromadzenia.

<strong>IBERSZER, Konrad, LITWINIUK, Maria, ZANIUK, Marcin, HURKAŁA, Kamil, ANTONIK, Dominika, DENYS, Barbara, G&Oacute;RA, Karolina, ZDZIENNICKI, Wojciech, ZIMNICKI, Patryk &amp; LATO, Marta. Influence of social media on the fight against COVID-19 pandemic &ndash; literature review.</strong>&nbsp;<strong>Journal of Education, Health and Sport. 2023;</strong><strong>39</strong><strong>(1):</strong><strong>17-28.</strong><strong>&nbsp;eISSN 2391-8306. DOI</strong>&nbsp;<strong>http://dx.doi.org/10.12775/JEHS.2023.39.01.002</strong> <strong>https://apcz.umk.pl/JEHS/article/view/43861</strong> <strong>https://zenodo.org/record/8016730</strong> &nbsp; &nbsp; &nbsp; &nbsp; &nbsp; <strong>The journal has had 40 points in Ministry of Education and Science of Poland parametric evaluation. Annex to the announcement of the Minister of Education and Science of December 21, 2021. No. 32343.</strong> <strong>Has a Journal&#39;s Unique Identifier: 201159. Scientific disciplines assigned: Physical Culture Sciences (Field of Medical sciences and health sciences); Health Sciences (Field of Medical Sciences and Health Sciences).</strong> <strong>Punkty Ministerialne z 2019 - aktualny rok 40 punkt&oacute;w. Załącznik do komunikatu Ministra Edukacji i Nauki z dnia 21 grudnia 2021 r. Lp. 32343. Posiada Unikatowy Identyfikator Czasopisma: 201159.</strong> <strong>Przypisane dyscypliny naukowe: Nauki o kulturze fizycznej (Dziedzina nauk medycznych i nauk o zdrowiu); Nauki o zdrowiu (Dziedzina nauk medycznych i nauk o zdrowiu).</strong> <strong>&copy; The Authors 2023;</strong> <strong>This article is published with open access at Licensee Open Journal Systems of Nicolaus Copernicus University in Torun, Poland</strong> <strong>Open Access. This article is distributed under the terms of the Creative Commons Attribution Noncommercial License which permits any noncommercial use, distribution, and reproduction in any medium, provided the original author (s) and source are credited. This is an open access article licensed under the terms of the Creative Commons Attribution Non commercial license Share alike.</strong> <strong>(http://creativecommons.org/licenses/by-nc-sa/4.0/) which permits unrestricted, non commercial use, distribution and reproduction in any medium, provided the work is properly cited.</strong> <strong>The authors declare that there is no conflict of interests regarding the publication of this paper.</strong> <strong>Received: </strong><strong>05</strong><strong>.</strong><strong>05.</strong><strong>2023. Revised: </strong><strong>05</strong><strong>.0</strong><strong>6</strong><strong>.2023. Accepted: </strong><strong>05</strong><strong>.0</strong><strong>6</strong><strong>.2023. Published: </strong><strong>13</strong><strong>.0</strong><strong>6</strong><strong>.2023.</strong> &nbsp; &nbsp; &nbsp; &nbsp; &nbsp; <strong>Influence of social media on the fight against COVID - 19 pandemic &ndash; literature review</strong> <strong>Wpływ social medi&oacute;w na walkę z pandemią COVID - 19 &ndash; przegląd literatury</strong> &nbsp; Konrad Iberszer¹, Maria Litwiniuk², Marcin Zaniuk³, Kamil Hurkała⁴, Dominika Antonik⁵, Barbara Denys⁶, Karolina G&oacute;ra⁷, Wojciech Zdziennicki⁸, Patryk Zimnicki⁹, Marta Lato¹⁰, &nbsp; ¹&nbsp;Samodzielny Publiczny Szpital Kliniczny nr 4, ul. Jaczewskiego 8, 20-954 Lublin, Poland ²&nbsp;WOJEW&Oacute;DZKI SZPITAL SPECJALISTYCZNY im. Stefana Kardynała Wyszyńskiego Samodzielny Publiczny Zakład Opieki Zdrowotnej w Lublinie,&nbsp; Al. Kraśnicka 100, 20-718 Lublin, Poland ³&nbsp;Samodzielny Publiczny Zakład Opieki Zdrowotnej MSWiA w Lublinie, ul. Grenadier&oacute;w 3, 20-331 Lublin, Poland ⁴&nbsp;Samodzielny Publiczny Szpital Wojew&oacute;dzki im. Papieża Jana Pawła II w Zamościu, ul. Aleje Jana Pawła II 10, 22-400 Zamość, Poland&nbsp; ⁵&nbsp;5 Wojskowy Szpital Kliniczny z Polikliniką w Krakowie, ul. Wrocławska ⅓, 30-901 Krak&oacute;w, Poland ⁶&nbsp;WOJEW&Oacute;DZKI SZPITAL SPECJALISTYCZNY im. Stefana Kardynała Wyszyńskiego Samodzielny Publiczny Zakład Opieki Zdrowotnej w Lublinie,&nbsp; Al. Kraśnicka 100, 20-718 Lublin, Poland ⁷Samodzielny Publiczny Szpital Kliniczny nr 4, ul. Jaczewskiego 8, 20-954 Lublin, Poland ⁸&nbsp;Uniwersytecki Szpital Kliniczny w Poznaniu - ul. Przybyszewskiego 49, 60-355 Poznań, Poland ⁹Samodzielny Publiczny Zakład Opieki Zdrowotnej MSWiA w Lublinie, ul. Grenadier&oacute;w 3, 20-331 Lublin, Poland ¹⁰&nbsp;SZPITAL SPECJALISTYCZNY IM.J.DIETLA W KRAKOWIE - Skarbowa 1, 31-121 Krak&oacute;w, Poland &nbsp; Konrad Iberszer, ORCiD: 0000-0002-4290-9883; e-mail: konrad.iberszer@gmail.com&nbsp; Maria Litwiniuk, ORCiD: 0009-0004-5396-7482; e-mail: litwiniuk.mm@gmail.com&nbsp; Marcin Zaniuk, ORCiD: 0000-0003-4643-0594; e-mail: marcin.zaniuk@gmail.com&nbsp; Kamil Hurkała, ORCiD: 0009-0007-5961-9894; e-mail: kamilhurkala@gmail.com&nbsp; Dominika Antonik, ORCiD: 0009-0004-7575-8016; e-mail: antonikdominika97@gmail.com&nbsp; Barbara Denys, ORCiD: 0009-0003-1951-1142; e-mail: barbaradenys11@gmail.com Karolina G&oacute;ra, ORCiD: 0000-0002-5377-3010; e-mail: gora.karolina7@gmail.com Wojciech Zdziennicki, ORCiD: 0009-0005-1254-9740; e-mail: wojtekzdziennicki@gmail.com&nbsp; Patryk Zimnicki, ORCiD: 0000-0002-5808-8661; e-mail: patryk.zimnicki.97@o2.pl Marta Lato, ORCiD: 0000-0003-4121-3400; e-mail:coronarysulcus@gmail.com&nbsp; &nbsp; &nbsp; &nbsp; <strong>ABSTRAKT</strong> <strong>Wprowadzenie I cel pracy</strong>: COVID-19 to choroba dr&oacute;g oddechowych będąca wynikiem zakażenia drugim koronawirusem ciężkiego ostrego zespołu oddechowego, SARS-CoV-2. Brak wiedzy na temat wirusa i lęk przed infekcją sprawiały, że media stanęły przed wyzwaniem, jakim była jasna i skuteczna komunikacja dotycząca ryzyka zdrowotnego. Celem naszej pracy było om&oacute;wienie i podsumowanie doniesień na ten temat dostępnych w literaturze w taki spos&oacute;b, aby zwiększyć szansę na skuteczne i bezpieczne wykorzystywanie przekazu medialnego w przyszłych sytuacjach kryzysowych. <strong>Aktualny stan wiedzy</strong>: W trakcie pandemii portale społecznościowe były wykorzystywane w celu publikowania informacji na temat potencjalnych zagrożeń dla zdrowia. Media społecznościowe odegrały dużą rolę w procesie edukacji, zar&oacute;wno szkolnej, jak i ochotnik&oacute;w czy pracownik&oacute;w ochrony zdrowia.. Należy mieć jednak na uwadze, że spos&oacute;b, w jaki rozprzestrzeniane są informacje w mediach społecznościowych może być przytłaczające dla wielu pracownik&oacute;w ochrony zdrowia. Ponadto, regularna ekspozycja na media społecznościowe korelowała z wysokimi szansami wystąpienia lęk&oacute;w oraz depresji. Fałszywe doniesienia dotyczące szczepionek na COVID &ndash; 19 podważały zaufanie społeczne do szczepień szczeg&oacute;lnie w okresie, kiedy szczepionki zostały wprowadzone do dystrybucji. <strong>Podsumowanie</strong>: Media społecznościowe były jednym z gł&oacute;wnych źr&oacute;deł informacji po wybuchu pandemii. Dzięki platformom takich jak Twitter, możliwe było znalezienie istotnych informacji od rzetelnych autor&oacute;w. Nie wolno jednak bagatelizować zjawiska, jakim jest infodemia. Dezinformacja i teorie spiskowe mogą mieć negatywny wpływ na zdrowie psychiczne. Kluczowe jest zatem zrozumienie mechanizm&oacute;w i ulepszenie system&oacute;w zarządzających przepływem informacji. <strong>Keywords</strong>: &bdquo;COVID-19&rdquo;, &bdquo;Social Media&rdquo;, &ldquo;Pandemic&rdquo;, &ldquo;Vaccine hesistancy&rdquo;, &ldquo;Mental Health&rdquo; &nbsp; <strong>ABSTRACT</strong> <strong>Introduction and purpose of the study</strong>: COVID-19 is a respiratory illness resulting from infection with the second coronavirus of Severe Acute Respiratory Syndrome, SARS-CoV-2. Lack of knowledge about the virus and fear of infection made it challenging for the media to communicate clearly and effectively about health risks. The purpose of our work was to discuss and summarize reports on this topic available in the literature in such a way as to increase the chances of effective and safe use of media messages in future emergencies. <strong>Current state of knowledge</strong>: During the pandemic, social networks were used to post information about potential health risks. Social media played a large role in the education process, both for schools and for volunteers or health care workers. However, it is important to keep in mind that the way information is spread on social media can be overwhelming for many health care workers. In addition, regular exposure to social media correlated with high odds of anxiety and depression. False reports about COVID - 19 vaccines undermined public confidence in vaccination especially during the period when the vaccines were introduced for distribution. <strong>Summary</strong>: Social media was one of the main sources of information after the pandemic outbreak. Thanks to platforms such as Twitter, it was possible to find relevant information from reliable authors. However, the phenomenon of infodemia should not be underestimated. Disinformation and conspiracy theories can have a negative impact on mental health. It is therefore crucial to understand the mechanisms and improve the systems that manage the flow of information. <strong>Keywords</strong>: &bdquo;COVID-19&rdquo;, &bdquo;Social Media&rdquo;, &ldquo;Pandemic&rdquo;, &ldquo;Vaccine hesistancy&rdquo;, &ldquo;Mental Health&rdquo;

<strong>KRZYSIEK, Urszula, PODG&Oacute;RSKA, Klaudia, PUŁA, Aleksandra, ARTYKIEWICZ, Klaudia, URBAŚ, Weronika, GRODKIEWICZ, Maria, KOZIEŁ, Paweł, CZARKOWSKI, Marcin, GORCZYCA, Kamila &amp; SŁUPCZYŃSKA, Aleksandra. Does a gluten-free diet affect the course of Hashimoto&rsquo;s disease? - the review of the literature</strong><strong>. </strong><strong>Journal of Education, Health and Sport. 202</strong><strong>3</strong><strong>;1</strong><strong>3</strong><strong>(</strong><strong>1</strong><strong>):</strong><strong>173</strong><strong>-</strong><strong>177</strong><strong>. eISSN 2391-8306. DOI </strong><strong>http://dx.doi.org/10.12775/JEHS.2023.13.01.02</strong><strong>6</strong> <strong>https://apcz.umk.pl/JEHS/article/view/40</strong><strong>906</strong> <strong>https://zenodo.org/record/7380007</strong> &nbsp; &nbsp; &nbsp; &nbsp; &nbsp; <strong>The journal has had 40 points in Ministry of Education and Science of Poland parametric evaluation. Annex to the announcement of the Minister of Education and Science of December 21, 2021. No. 32343.</strong> <strong>Has a Journal&#39;s Unique Identifier: 201159. Scientific disciplines assigned: Physical Culture Sciences (Field of Medical sciences and health sciences); Health Sciences (Field of Medical Sciences and Health Sciences).</strong> <strong>Punkty Ministerialne z 2019 - aktualny rok 40 punkt&oacute;w. Załącznik do komunikatu Ministra Edukacji i Nauki z dnia 21 grudnia 2021 r. Lp. 32343. Posiada Unikatowy Identyfikator Czasopisma: 201159.</strong> <strong>Przypisane dyscypliny naukowe: Nauki o kulturze fizycznej (Dziedzina nauk medycznych i nauk o zdrowiu); Nauki o zdrowiu (Dziedzina nauk medycznych i nauk o zdrowiu).</strong> <strong>&copy; The Authors 2022;</strong> <strong>This article is published with open access at Licensee Open Journal Systems of Nicolaus Copernicus University in Torun, Poland</strong> <strong>Open Access. This article is distributed under the terms of the Creative Commons Attribution Noncommercial License which permits any noncommercial use, distribution, and reproduction in any medium, provided the original author (s) and source are credited. This is an open access article licensed under the terms of the Creative Commons Attribution Non commercial license Share alike.</strong> <strong>(http://creativecommons.org/licenses/by-nc-sa/4.0/) which permits unrestricted, non commercial use, distribution and reproduction in any medium, provided the work is properly cited.</strong> <strong>The authors declare that there is no conflict of interests regarding the publication of this paper.</strong> <strong>Received: </strong><strong>17</strong><strong>.</strong><strong>1</strong><strong>0</strong><strong>.2022. Revised: </strong><strong>20</strong><strong>.1</strong><strong>1</strong><strong>.2022. Accepted: </strong><strong>30</strong><strong>.11.2022.</strong> &nbsp; &nbsp; &nbsp; &nbsp; &nbsp; <strong>Does a gluten-free diet affect the course of Hashimoto&#39;s disease? - </strong><strong>the review of the literature</strong> &nbsp; Urszula Krzysiek, Klaudia Podg&oacute;rska, Aleksandra Puła, Klaudia Artykiewicz, Weronika Urbaś, Aleksandra&nbsp;Słupczyńska, Maria Grodkiewicz, Paweł Kozieł, Marcin Czarkowski, Kamila Gorczyca &nbsp; <strong>Urszula Krzysiek 1,</strong> urszula.krzysiek@onet.eu, ORCID: 0000-0002-4712-2334 <strong>Klaudia Podg&oacute;rska 2,</strong> kpodgorska06@gmail.com, ORCID: 0000-0002-5109-900X <strong>Aleksandra Puła 3,</strong> aleksandrapula@gmail.com, ORCID:&nbsp;0000-0001-9001-5051 <strong>Klaudia Artykiewicz 2,</strong> klaudiaartykiewicz@gmail.com, ORCID: 0000-0003-2912-4691 <strong>Weronika Urbaś 4,</strong> weronikaurbass@gmail.com, ORCID: 0000-0002-5260-2172 <strong>Maria Grodkiewicz 4,</strong> marysiagrodkiewicz@gmail.com, ORCID: 0000-0002-6243-9102 &nbsp; <strong>Paweł Kozieł 4,</strong> &nbsp; pawelkoziel61@gmail.com, ORCID: 0000-0001-6069-6028 &nbsp; <strong>Marcin Czarkowski 4,</strong> &nbsp; marcin.czarkowski98@gmail.com, ORCID: 0000-0001-5663-2574 &nbsp; <strong>Kamila Gorczyca 2,</strong> &nbsp; kamila.gorczyca@o2.pl, ORCID:&nbsp;0000-0002-7976-0509 &nbsp; <strong>Aleksandra Słupczyńska 5,</strong> olaslup@gmail.com, ORCID: 0000-0003-3615-002X &nbsp; 1.Szpital Solec Sp&oacute;łka z Ograniczoną Odpowiedzialnością w Warszawie 2.Samodzielny Publiczny Szpital Kliniczny nr 4 w Lublinie 3.Wojew&oacute;dzki Szpital Specjalistyczny im.Kardynała Stefana Wyszyńskiego SPZOZ w Lublinie 4.&nbsp;Medical University of Lublin 5. Samodzielny Publiczny Szpital Kliniczny nr 1 w Lublinie &nbsp; &nbsp; &nbsp; &nbsp; &nbsp; &nbsp; <strong>Abstract</strong> <strong>Introduction and purpose</strong> The fashion for following a gluten-free diet is causing more and more people to opt for it. It is indicated in the treatment of celiac disease. Due to the high prevalence of Hashimoto&#39;s disease in the population and the lack of causal treatment for the disease, many researchers have tested the validity of gluten elimination for those burdened with it. This work aimed to review the results achieved so far and assess whether this diet has a real impact on the course of Hashimoto&#39;s disease. <strong>A brief description of the state of knowledge</strong> A PubMed database was searched for studies describing the relationship between gluten consumption and the course of Hashimoto&#39;s disease. Some studies indicated a potential beneficial effect of the introduced diet on thyroid function. However, these were mostly survey-based studies of questionable research quality. More reliable studies that took into account antibody and TSH levels showed no significant improvement in thyroid function in response to the diet. <strong>Conclusions</strong> Based on the studies reviewed, there is no need for a gluten-free diet in patients with chronic autoimmune thyroid disease. It has not been proven that gluten can provoke the body to produce autoantibodies that cause the destruction of thyroid tissue. It is more important to maintain a balanced diet rich in zinc, selenium, iodine, vitamin D3, and iron, as they are essential in the process of hormone production by the thyroid gland. &nbsp; <strong>Keywords</strong>: Hashimoto&#39;s thyroiditis;&nbsp;Autoimmune thyroid disorders; gluten-free diet; gluten; hypothyroidism

<strong>URBAŚ, Weronika, ARTYKIEWICZ, Klaudia, CZARKOWSKI, Marcin, GORCZYCA, Kamila, GRODKIEWICZ, Maria, KOZIEŁ, Paweł, KRZYSIEK, Urszula, PODG&Oacute;RSKA, Klaudia, PUŁA, Aleksandra &amp; SŁUPCZYŃSKA, Aleksandra. Hypothermia as a treatment option for hypoxic-ischemic encephalopathy in newborns &ndash; A literature review.</strong>&nbsp;<strong>Journal of Education, Health and Sport. 202</strong><strong>3</strong><strong>;1</strong><strong>3</strong><strong>(</strong><strong>1</strong><strong>):</strong><strong>100</strong><strong>-</strong><strong>104</strong><strong>. eISSN 2391</strong><strong>-8306. DOI </strong><strong>http://dx.doi.org/10.12775/JEHS.2023.13.01.01</strong><strong>6</strong> <strong>https://apcz.umk.pl/JEHS/article/view/40</strong><strong>914</strong> <strong>https://zenodo.org/record/7359985</strong> &nbsp; &nbsp; &nbsp; &nbsp; &nbsp; <strong>The journal has had 40 points in Ministry of Education and Science of Poland parametric evaluation. Annex to the announcement of the Minister of Education and Science of December 21, 2021. No. 32343.</strong> <strong>Has a Journal&#39;s Unique Identifier: 201159. Scientific disciplines assigned: Physical Culture Sciences (Field of Medical sciences and health sciences); Health Sciences (Field of Medical Sciences and Health Sciences).</strong> <strong>Punkty Ministerialne z 2019 - aktualny rok 40 punkt&oacute;w. Załącznik do komunikatu Ministra Edukacji i Nauki z dnia 21 grudnia 2021 r. Lp. 32343. Posiada Unikatowy Identyfikator Czasopisma: 201159.</strong> <strong>Przypisane dyscypliny naukowe: Nauki o kulturze fizycznej (Dziedzina nauk medycznych i nauk o zdrowiu); Nauki o zdrowiu (Dziedzina nauk medycznych i nauk o zdrowiu).</strong> <strong>&copy; The Authors 2022;</strong> <strong>This article is published with open access at Licensee Open Journal Systems of Nicolaus Copernicus University in Torun, Poland</strong> <strong>Open Access. This article is distributed under the terms of the Creative Commons Attribution Noncommercial License which permits any noncommercial use, distribution, and reproduction in any medium, provided the original author (s) and source are credited. This is an open access article licensed under the terms of the Creative Commons Attribution Non commercial license Share alike.</strong> <strong>(http://creativecommons.org/licenses/by-nc-sa/4.0/) which permits unrestricted, non commercial use, distribution and reproduction in any medium, provided the work is properly cited.</strong> <strong>The authors declare that there is no conflict of interests regarding the publication of this paper.</strong> <strong>Received: </strong><strong>17</strong><strong>.</strong><strong>10</strong><strong>.2022. Revised: </strong><strong>20</strong><strong>.1</strong><strong>1</strong><strong>.2022. Accepted: </strong><strong>23</strong><strong>.11.2022.</strong> &nbsp; &nbsp; &nbsp; &nbsp; <strong>Hypothermia as a treatment option for hypoxic-ischemic encephalopathy in newborns</strong> <strong>&ndash; A literature review</strong> &nbsp; &nbsp; <strong>Weronika&nbsp;Urbaś</strong><strong>¹</strong> Uniwersytet Medyczny w Lublinie https://orcid.org/0000-0002-5260-2172 e-mail: weronikaurbass@gmail.com &nbsp; <strong>Klaudia Artykiewicz</strong><strong>²</strong> Samodzielny Publiczny Szpital Kliniczny Nr 4 w Lublinie https://orcid.org/0000-0003-2912-4691 <strong>e-mail:</strong>&nbsp;klaudiaartykiewicz@gmail.com &nbsp; <strong>Marcin Czarkowski</strong><strong>³</strong> Uniwersytet Medyczny w Lublinie https://orcid.org/0000-0001-5663-2574 e-mail: marcin.czarkowski98@gmail.com &nbsp; <strong>Kamila Gorczyca</strong><strong>⁴</strong> Samodzielny Publiczny Szpital Kliniczny Nr 4 w Lublinie https://orcid.org/0000-0002-7976-0509 e-mail: kamila.gorczyca@o2.pl &nbsp; <strong>Maria Grodkiewicz</strong><strong>⁵</strong> Uniwersytet Medyczny w Lublinie https://orcid.org/0000-0002-6243-9102 e-mail: marysiagrodkiewicz@gmail.com &nbsp; <strong>Paweł Kozieł</strong><strong>⁶</strong> Uniwersytet Medyczny w Lublinie https://orcid.org/0000-0001-6069-6028 e-mail: pawelkoziel61@gmail.com &nbsp; <strong>Urszula Krzysiek</strong><strong>⁷</strong> Szpital Solec Sp&oacute;łka z Ograniczoną Odpowiedzialnością w Warszawie https://orcid.org/0000-0002-4712-2334 e-mail: urszula.krzysiek@onet.eu &nbsp; <strong>Klaudia Podg&oacute;rska</strong><strong>⁸</strong> Samodzielny Publiczny Szpital Kliniczny Nr 4 w Lublinie&nbsp; https://orcid.org/0000-0002-5109-900X e-mail: kpodgorska06@gmail.com &nbsp; &nbsp; <strong>Aleksandra Puła</strong><strong>⁹</strong> Wojew&oacute;dzki Szpital Specjalistyczny im. Kardynała Stefana Wyszyńskiego SPOZ w Lublinie https://orcid.org/0000-0001-9001-5051 e-mail: aleksandrapula@gmail.com &nbsp; <strong>Aleksandra Słupczyńska</strong><strong>¹⁰</strong> Samodzielny Publiczny Szpital Kliniczny Nr 1 w Lublinie https://orcid.org/0000-0003-3615-002X e-mail: olaslup@gmail.com &nbsp; &nbsp; &nbsp; &nbsp; &nbsp; &nbsp; <strong>Autor korespondencyjny:</strong> <strong>Weronika&nbsp;Urbaś</strong><strong>¹</strong> Uniwersytet Medyczny w Lublinie https://orcid.org/0000-0002-5260-2172 e-mail: weronikaurbass@gmail.com &nbsp; &nbsp; <strong>ABSTRACT</strong> <strong>Introduction and purpose</strong>: Neonatal asphyxia is a medical condition in which the neonate is not able to maintain sufficient respiratory function. The hypoxia may be caused by either an impaired respiratory activity of the neonate or an interruption of blood flow to the placenta in the period immediately before or during delivery, which resulted in inadequate oxygen perfusion to vital organs. &nbsp; <strong>Description of the state of knowledge:</strong>&nbsp;Hypoxic-ischaemic encephalopathy (HIE) is a form of perinatal hypoxia, occurring in newborns after the 35th week of gestation and presenting along with neurological disorders. In fact, it is a major cause of death and infant disability. The incidence of HIE is approximately 2-5 per 1000 live births. The standard recommended treatment for perinatal hypoxic-ischaemic encephalopathy is therapeutic hypothermia. There are two methods used: selective head cooling with moderate whole-body hypothermia (SHC) and whole-body hypothermia (WBC). In both cases, metabolism and neural tissue destruction are slowed down. &nbsp; <strong>Conclusions:</strong>&nbsp;Therapeutic hypothermia is a promising treatment option for neonatal encephalopathy. Thus, it decreases the risk of death and neurological deficits in the form of cerebral palsy, epilepsy and psychomotor retardation. Whole-body hypothermia appears to be a more successful method than selective head cooling, however more research is still needed. &nbsp; <strong>Key words:</strong>&nbsp;hypothermia; treatment; newborn; hypoxic-ischemic encephalopathy

<strong>ARTYKIEWICZ, Klaudia, CZARKOWSKI, Marcin, GORCZYCA, Kamila, GRODKIEWICZ, Maria, KOZIEŁ, Paweł, KRZYSIEK, Urszula, PODG&Oacute;RSKA, Klaudia, PUŁA, Aleksandra, SŁUPCZYŃSKA, Aleksandra &amp; URBAŚ, Weronika. Celiac disease - a review on recent advances in characteristics, diagnostic and treatments</strong><strong>. </strong><strong>Journal of Education, Health and Sport. 202</strong><strong>3</strong><strong>;1</strong><strong>3</strong><strong>(</strong><strong>1</strong><strong>):</strong><strong>11</strong><strong>-</strong><strong>17</strong><strong>. eISSN 2391</strong><strong>-8306. DOI </strong><strong>http://dx.doi.org/10.12775/JEHS.202</strong><strong>3</strong><strong>.</strong><strong>13</strong><strong>.</strong><strong>01</strong><strong>.0</strong><strong>01</strong> <strong>https://apcz.umk.pl/JEHS/article/view/40</strong><strong>835</strong> <strong>https://zenodo.org/record/7348088</strong> &nbsp; &nbsp; &nbsp; &nbsp; &nbsp; <strong>The journal has had 40 points in Ministry of Education and Science of Poland parametric evaluation. Annex to the announcement of the Minister of Education and Science of December 21, 2021. No. 32343.</strong> <strong>Has a Journal&#39;s Unique Identifier: 201159. Scientific disciplines assigned: Physical Culture Sciences (Field of Medical sciences and health sciences); Health Sciences (Field of Medical Sciences and Health Sciences).</strong> <strong>Punkty Ministerialne z 2019 - aktualny rok 40 punkt&oacute;w. Załącznik do komunikatu Ministra Edukacji i Nauki z dnia 21 grudnia 2021 r. Lp. 32343. Posiada Unikatowy Identyfikator Czasopisma: 201159.</strong> <strong>Przypisane dyscypliny naukowe: Nauki o kulturze fizycznej (Dziedzina nauk medycznych i nauk o zdrowiu); Nauki o zdrowiu (Dziedzina nauk medycznych i nauk o zdrowiu).</strong> <strong>&copy; The Authors 2022;</strong> <strong>This article is published with open access at Licensee Open Journal Systems of Nicolaus Copernicus University in Torun, Poland</strong> <strong>Open Access. This article is distributed under the terms of the Creative Commons Attribution Noncommercial License which permits any noncommercial use, distribution, and reproduction in any medium, provided the original author (s) and source are credited. This is an open access article licensed under the terms of the Creative Commons Attribution Non commercial license Share alike.</strong> <strong>(http://creativecommons.org/licenses/by-nc-sa/4.0/) which permits unrestricted, non commercial use, distribution and reproduction in any medium, provided the work is properly cited.</strong> <strong>The authors declare that there is no conflict of interests regarding the publication of this paper.</strong> <strong>Received: </strong><strong>02</strong><strong>.</strong><strong>11</strong><strong>.2022. Revised: </strong><strong>20</strong><strong>.1</strong><strong>1</strong><strong>.2022. Accepted: </strong><strong>22</strong><strong>.11.2022.</strong> &nbsp; &nbsp; &nbsp; &nbsp; &nbsp; <strong>Celiac disease- a review on recent advances in characteristics, diagnostic and treatments</strong> &nbsp; <strong>Klaudia Artykiewicz</strong><strong>¹</strong> Samodzielny Publiczny Szpital Kliniczny Nr 4 w Lublinie https://orcid.org/0000-0003-2912-4691 <strong>e-mail:</strong>&nbsp;klaudiaartykiewicz@gmail.com &nbsp; <strong>Marcin Czarkowski</strong><strong>²</strong> Uniwersytet Medyczny w Lublinie https://orcid.org/0000-0001-5663-2574 e-mail: marcin.czarkowski98@gmail.com &nbsp; <strong>Kamila Gorczyca</strong><strong>³</strong> Samodzielny Publiczny Szpital Kliniczny Nr 4 w Lublinie https://orcid.org/0000-0002-7976-0509 e-mail: kamila.gorczyca@o2.pl &nbsp; <strong>Maria Grodkiewicz</strong><strong>⁴</strong>&nbsp; Uniwersytet Medyczny w Lublinie https://orcid.org/0000-0002-6243-9102 e-mail: marysiagrodkiewicz@gmail.com &nbsp; <strong>Paweł Kozieł</strong><strong>⁵</strong> Uniwersytet Medyczny w Lublinie https://orcid.org/0000-0001-6069-6028 e-mail: pawelkoziel61@gmail.com &nbsp; <strong>Urszula Krzysiek</strong><strong>⁶</strong> Szpital Solec Sp&oacute;łka z Ograniczoną Odpowiedzialnością w Warszawie https://orcid.org/0000-0002-4712-2334 e-mail: urszula.krzysiek@onet.eu &nbsp; <strong>Klaudia Podg&oacute;rska</strong><strong>⁷</strong> Samodzielny Publiczny Szpital Kliniczny Nr 4 w Lublinie&nbsp; https://orcid.org/0000-0002-5109-900X e-mail: kpodgorska06@gmail.com &nbsp; <strong>Aleksandra Puła</strong><strong>⁸</strong> Wojew&oacute;dzki Szpital Specjalistyczny im. Kardynała Stefana Wyszyńskiego SPOZ w Lublinie https://orcid.org/0000-0001-9001-5051 e-mail: aleksandrapula@gmail.com &nbsp; <strong>Aleksandra Słupczyńska</strong><strong>⁹</strong> Samodzielny Publiczny Szpital Kliniczny Nr 1 w Lublinie https://orcid.org/0000-0003-3615-002X e-mail: olaslup@gmail.com &nbsp; <strong>Weronika&nbsp;Urbaś</strong><strong>¹⁰</strong> Uniwersytet Medyczny w Lublinie https://orcid.org/0000-0002-5260-2172 e-mail: weronikaurbass@gmail.com &nbsp; <strong>Autor korespondencyjny:</strong> <strong>Klaudia Artykiewicz</strong> Samodzielny Publiczny Szpital Kliniczny Nr 4 w Lublinie https://orcid.org/0000-0003-2912-4691 <strong>e-mail:</strong>&nbsp;klaudiaartykiewicz@gmail.com,&nbsp; &nbsp; <strong>Abstract</strong> &nbsp; <strong>Introduction and purpose:</strong> Celiac disease occurs in 1% of the general population. However, many cases remain unrecognized. The disease&nbsp;is a chronic immune-mediated disorder triggered by the ingestion of gluten that appears in individuals with genetic susceptibility. Celiac disease can develop in paediatric patients as well as adults. The purpose of this review is to analyze the newest information on the characteristics, diagnosis and treatment of patients with celiac disease.&nbsp; &nbsp; <strong>Material and methods</strong>: This review was based on available data collected in the PubMed database and published between 2015 and 2022. The research was done by looking through keywords such as: &ldquo;celiac disease&rdquo;, &ldquo;Gluten-Free Diet&rdquo;, &ldquo;diagnosis&rdquo; and &ldquo;treatment&rdquo;. <strong>Results:</strong> The diagnosis of celiac disease is most often delayed due to the broad spectrum of presentations. Screening of at-risk individuals is important to progress the diagnosis. It is additionally crucial to raise clinicians&#39; attention to non-specific parenteral symptoms that may indicate celiac disease. The majority of the symptoms arise from nutritional deficiencies caused by intestinal malabsorption. According to scientific reports, the most common deficiencies of people with celiac disease are iron, folic acid, vitamin B12, fat-soluble vitamins and a calcium. &nbsp; <strong>Conclusions:</strong> Recent years have seen the emergence of research into new therapeutic options, but their efficacy and safety still need to be evaluated more thoroughly. Strict adherence to a gluten-free diet by patients is still the only treatment option at present. Celiac disease, due to the constant increase in knowledge about its pathogenesis, diagnosis and treatment is an important material for further research. &nbsp; &nbsp; <strong>Keywords: </strong>Celiac disease, Gluten-Free Diet, Diagnosis, Treatment

<strong>GRUCA, Dariusz, ANTONIAK, Krzysztof, WAIS, Marcin &amp; ZAJĄC, Marlena. Amantadine toxic effect and acute psychosis &ndash; a case report</strong><strong>.</strong><strong>&nbsp;Journal of Education, Health and Sport. 202</strong><strong>3</strong><strong>;1</strong><strong>3</strong><strong>(</strong><strong>3</strong><strong>):</strong><strong>85-89</strong><strong>. eISSN 2391-8306. DOI</strong>&nbsp;<strong>http://dx.doi.org/10.12775/JEHS.2023.13.03.01</strong><strong>2</strong> <strong>https://apcz.umk.pl/JEHS/article/view/41</strong><strong>594</strong> <strong>https://zenodo.org/record/7553880</strong> &nbsp; &nbsp; &nbsp; &nbsp; &nbsp; <strong>The journal has had 40 points in Ministry of Education and Science of Poland parametric evaluation. Annex to the announcement of the Minister of Education and Science of December 21, 2021. No. 32343.</strong> <strong>Has a Journal&#39;s Unique Identifier: 201159. Scientific disciplines assigned: Physical Culture Sciences (Field of Medical sciences and health sciences); Health Sciences (Field of Medical Sciences and Health Sciences).</strong> <strong>Punkty Ministerialne z 2019 - aktualny rok 40 punkt&oacute;w. Załącznik do komunikatu Ministra Edukacji i Nauki z dnia 21 grudnia 2021 r. Lp. 32343. Posiada Unikatowy Identyfikator Czasopisma: 201159.</strong> <strong>Przypisane dyscypliny naukowe: Nauki o kulturze fizycznej (Dziedzina nauk medycznych i nauk o zdrowiu); Nauki o zdrowiu (Dziedzina nauk medycznych i nauk o zdrowiu).</strong> <strong>&copy; The Authors 202</strong><strong>3</strong><strong>;</strong> <strong>This article is published with open access at Licensee Open Journal Systems of Nicolaus Copernicus University in Torun, Poland</strong> <strong>Open Access. This article is distributed under the terms of the Creative Commons Attribution Noncommercial License which permits any noncommercial use, distribution, and reproduction in any medium, provided the original author (s) and source are credited. This is an open access article licensed under the terms of the Creative Commons Attribution Non commercial license Share alike.</strong> <strong>(http://creativecommons.org/licenses/by-nc-sa/4.0/) which permits unrestricted, non commercial use, distribution and reproduction in any medium, provided the work is properly cited.</strong> <strong>The authors declare that there is no conflict of interests regarding the publication of this paper.</strong> <strong>Received: </strong><strong>30</strong><strong>.</strong><strong>12</strong><strong>.2022. Revised: </strong><strong>17</strong><strong>.</strong><strong>01</strong><strong>.202</strong><strong>3</strong><strong>. Accepted: </strong><strong>20</strong><strong>.</strong><strong>01</strong><strong>.202</strong><strong>3</strong><strong>.</strong> &nbsp; &nbsp; &nbsp; &nbsp; &nbsp; &nbsp; <strong>Amantadine toxic effect and acute psychosis &ndash; a case report</strong> &nbsp; <strong>Dariusz Gruca</strong><strong>¹</strong><strong>,</strong>&nbsp;<strong>Krzysztof Antoniak</strong><strong>¹</strong><strong>, Marcin Wais</strong><strong>¹</strong><strong>, Marlena Zając</strong><strong>¹</strong><strong>,</strong> &nbsp; ¹Studenckie Koło Naukowe przy Klinice Toksykologii, Uniwersytet Medyczny w Lublinie &nbsp; &nbsp; Dariusz Gruca; dariusz.gruca1@gmail.com; ORCID: 0000-0002-5583-1229; Krzysztof Antoniak; krzyss.anton@gmail.com; ORCID: 0000-0001-8065-081X Marcin Wais; marcin.wais0805@gmail.com; ORCID: 0000-0003-4757-8582 Marlena Zając; marlenzajac11@gmail.com; ORCID:&nbsp;0000-0002-6251-0175; &nbsp; &nbsp; <strong>Abstract:</strong> <strong>Introduction and purpose:</strong>&nbsp;The pandemic of COVID-19 has induced patients to use different ways to struggle with SARS-CoV-2 infection. Amantadine has become more popular as a supportive drug in the treatment of COVID-19 symptoms. This report presents a case of a young, previously healthy woman hospitalized in the Toxicology and Cardiology Department because of acute psychosis induced by amantadine intoxication. <strong>Brief description of the state of knowledge:</strong>&nbsp;Acute psychosis can be caused by several medications, including psychostimulants, antibiotics, antivirals, and antiparkinsonians. Amantadine has primarily dopaminergic with some anticholinergic properties and is used predominantly as an adjuvant agent in the management of Parkinson&#39;s disease treatment. Psychomotor agitation, insomnia, excessive verbosity, delusions, and behavioral disturbances which are typical toxic effects of amantadine primarily affecting the central nervous system which were presented by patient described in this case report. <strong>Conclusions:</strong>&nbsp;Our case illustrates the negative effects of amantadine on the central nervous system when given at the recommended dose to young, healthy women. Despite being rare, this induced psychosis may become more common, especially while becoming more popular as a supportive drug in COVID-19 treatment. While prescribing amantadine clinicians should be aware of the rapid onset of its psychotic complications. <strong>Key words: </strong>amantadine; intoxication; acute psychosis; COVID-19;

Traktaty pedagogiczne chętnie przybierały postać listu &ndash; formy wypowiedzi literackiej (często o charakterze dydaktycznym, moralizatorskim) skierowanej nie tylko do konkretnego adresata, ale i do szerszego kręgu odbiorc&oacute;w, co dawało możliwości popularyzowania r&oacute;żnych treści. W artykule przywołano następujące dzieła: z 1393 r. Pietro Paolo Vergeriego <em>De ingenius moribus ac liberalibus studiis </em>(w 1564 r. przełożone na polski przez Marcina Kwiatkowskiego <em>Książeczki rozkoszne o poczciwem wychowaniu dziatek</em>), Eneasza Sylwiusza Piccolominiego (p&oacute;źniejszego papieża Piusa II) <em>De liberorum educatione </em>(1443), list kr&oacute;lowej Elżbiety do syna Władysława Jagiellończyka z 1502 r. (wzorowany na liście Eneasza Sylwiusza i rozprawie pedagogicznej z 1491 r. Maffea Vegia <em>De educatione liberorum et eorum claris moribus</em>) oraz traktat pedagogiczny w formie list&oacute;w biskupa Piotra Tomickiego z 1535 r. i epistołę do syn&oacute;w wojewody poznańskiego Jana Ostroroga z lat 1605 &ndash;1615.

Manuel Teget-Welz: Martin Schaffner. Leben und Werk eines Ulmer Malers zwischen Spätmittelalter und Renaissance. (Forschungen zur Geschichte der Stadt Ulm, Band 32). Kommissionsverlag W. Kohlhammer Stuttgart 2008. 704 Seiten und 115 teils farbige Abbildungen. Pappband € 60,–. ISBN 978-3-17-020556-7

<strong>KĘDRA, Kamila, MICHALIK, Izabela, OLESZKO, Michał &amp; WIĄCEK, Marcin. Case report - sulfonylurea poisoning mimicking vertebrobasilar acute ischemic stroke.</strong>&nbsp;<strong>Journal of Education, Health and Sport. 2023;1</strong><strong>9</strong><strong>(1):</strong><strong>30-35</strong><strong>. eISSN 2391-8306. DOI </strong><strong>http://dx.doi.org/10.12775/JEHS.2023.19.01.00</strong><strong>4</strong> <strong>https://apcz.umk.pl/JEHS/article/view/431</strong><strong>89</strong> <strong>https://zenodo.org/record/7810001</strong> &nbsp; &nbsp; &nbsp; &nbsp; &nbsp; <strong>The journal has had 40 points in Ministry of Education and Science of Poland parametric evaluation. Annex to the announcement of the Minister of Education and Science of December 21, 2021. No. 32343.</strong> <strong>Has a Journal&#39;s Unique Identifier: 201159. Scientific disciplines assigned: Physical Culture Sciences (Field of Medical sciences and health sciences); Health Sciences (Field of Medical Sciences and Health Sciences).</strong> <strong>Punkty Ministerialne z 2019 - aktualny rok 40 punkt&oacute;w. Załącznik do komunikatu Ministra Edukacji i Nauki z dnia 21 grudnia 2021 r. Lp. 32343. Posiada Unikatowy Identyfikator Czasopisma: 201159.</strong> <strong>Przypisane dyscypliny naukowe: Nauki o kulturze fizycznej (Dziedzina nauk medycznych i nauk o zdrowiu); Nauki o zdrowiu (Dziedzina nauk medycznych i nauk o zdrowiu).</strong> <strong>&copy; The Authors 2023;</strong> <strong>This article is published with open access at Licensee Open Journal Systems of Nicolaus Copernicus University in Torun, Poland</strong> <strong>Open Access. This article is distributed under the terms of the Creative Commons Attribution Noncommercial License which permits any noncommercial use, distribution, and reproduction in any medium, provided the original author (s) and source are credited. This is an open access article licensed under the terms of the Creative Commons Attribution Non commercial license Share alike.</strong> <strong>(http://creativecommons.org/licenses/by-nc-sa/4.0/) which permits unrestricted, non commercial use, distribution and reproduction in any medium, provided the work is properly cited.</strong> <strong>The authors declare that there is no conflict of interests regarding the publication of this paper.</strong> <strong>Received: </strong><strong>17</strong><strong>.0</strong><strong>3</strong><strong>.2023. Revised: 1</strong><strong>8</strong><strong>.03.2023. Accepted: </strong><strong>06</strong><strong>.0</strong><strong>4</strong><strong>.2023. Published: </strong><strong>08</strong><strong>.0</strong><strong>4</strong><strong>.2023.</strong> &nbsp; &nbsp; &nbsp; &nbsp; &nbsp; <strong><em>Case report</em></strong> &nbsp; <strong>Case report- sulfonylurea poisoning mimicking vertebrobasilar acute ischemic stroke</strong> <strong>Kamila Kędra</strong><strong>¹</strong><strong>, Izabela Michalik</strong><strong>¹</strong><strong>,</strong>&nbsp;<strong>Michał Oleszko</strong><strong>¹</strong><strong>, </strong><strong>Marcin Wiącek</strong><strong>¹</strong> Department of Neurology, Institute of Medical Sciences, Medical College of Rzeszow University, 35-301 Rzeszow, Poland &nbsp; <strong>Abstract:</strong>&nbsp;<em>Background</em>: We report the case of sulfonylurea induced hypoglycemia manifesting as acute encephalopathy with focal neurological signs misdiagnosed as posterior circulation acute ischemic stroke (AIS) and discuss the potential effects of hypoglycemia on central nervous system, as well as its differentiation from AIS. <em>Case presentation</em>: A 64-year-old patient with type II diabetes treated with glimepiride was transferred to the Department of Neurology after the procedure of radical prostatectomy. On admission, the patient was unconscious with four limb paresis and bilateral Babinski sign. Non-contrast head CT and CT angiography vessels did not reveal any abnormalities. Due to exceeded therapeutic window the patient was disqualified from intravenous thrombolysis. At the admission hypoglycemia was observed and promptly corrected with the 5% dextrose infusion. For the next 72 hours repeated intravenous glucose infusions were needed to maintain its levels above 70 mg/dl. Based on the absence of ischemic changes on MRI and repeated decreases in glucose level for the next 3 days, glimepiride induced hypoglycemic encephalopathy was diagnosed. Within 24 hours of admission the patient regained consciousness and eventually presented four-limb paresis as a result of prolonged neuroglycopenia. <em>Conclusions:</em>&nbsp;Prolonged insufficient brain nutrition can result in permanent or long-lasting brain damage, manifesting as impaired consciousness and focal neurological signs. Perioperative sulfonylureas intake may result in prolonged hypoglycemia. <strong>Keywords:</strong>&nbsp;sulfonylurea-poisoning; neuroglycopenia; tetraplegia; hemiparesis

Jeon, Jiseung, Kim, Heung Chul, Donnelly, Martin J., Choi, Kwang Shik (2024): Genetic diversity and WolbaChia infection in the Japanese encephalitis virus vector CUlex tritaeniorhynChUS in the Republic of Korea. Parasites &amp; Vectors (518) 17 (1): 1-13, DOI: 10.1186/s13071-024-06595-w, URL: https://doi.org/10.1186/s13071-024-06595-w

Martin Furtwängler u. a. (Hrsg.): Verfassungen und Verfassungsjubiläen in Baden und Württemberg 1818/19 – 1919 – 2019 (Veröffentlichungen der Kommission für geschichtliche Landeskunde in Baden-Württemberg, Reihe B, Forschungen, Bd. 229). W. Kohlhammer Verlag Stuttgart 2020. 273 Seiten mit einigen Abbildungen. Fest gebunden € 28,–. ISBN 978-3-17-039339-4

Reports excavations in the courtyard area, including details of: `The modern pottery' by G Cruickshank &amp; R S Will (1114); `The clay pipes' by C J M Martin (1116); `Glass' by K R Murdoch (1116--17); and `Animal bones' by Catherine Smith &amp; G W Ian Hodgson (1117).

AbstractThe Chanter Field is located 11 krn southeast of the Piper Alpha platform location in Block 15/17. The field was discovered by the 15/17–13 well, which tested 37.8° API crude from Galley sandstone turbidites and 52.1&amp; API gas-condensate from the shallow marine sands of the Piper Formation. The Galley sandstone reservoir is overpressured, whereas the Piper sandstone reservoir is normally pressured. The bulk of the field occupies the culmination of a structural terrace on the downthrown side of the main E-W fault forming the northern margin of the Witch Ground Graben in this area. It has dip closure to the east, south and west and fault closure to the north. The 'main block' gas-water contact of 13 080 ft TVSS in the Piper sandstone and the oil-water contact of 12 240 ft TVSS in the Galley sandstone were deduced from wireline pressure measurements and have not been encountered in wells. Estimated proved reserves of 4.6 MMBBL of crude oil and condensate liquids and 20.8 BCF of gas will be produced through a cluster of wells tied back to the Piper Field by a subsea pipeline.

Abstract. Microfossil assemblages provide valuable records to investigate variability in continental margin biogeochemical cycles, including dynamics of the oxygen minimum zone (OMZ). Analyses of modern assemblages across environmental gradients are necessary to understand relationships between assemblage characteristics and environmental factors. Five cores were analyzed from the San Diego margin (32∘42′00′′ N, 117∘30′00′′ W; 300–1175 m water depth) for core top benthic foraminiferal assemblages to understand relationships between community assemblages and spatial hydrographic gradients as well as for down-core benthic foraminiferal assemblages to identify changes in the OMZ through time. Comparisons of benthic foraminiferal assemblages from two size fractions (63–150 and &gt;150 µm) exhibit similar trends across the spatial and environmental gradient or in some cases exhibit more pronounced spatial trends in the &gt;150 µm fraction. A range of species diversity exists within the modern OMZ (1.910–2.586 H, Shannon index), suggesting that diversity is not driven by oxygenation alone. We identify two hypoxic-associated species (B. spissa and U. peregrina), one oxic-associated species (G. subglobosa) and one OMZ edge-associated species (B. argentea). Down-core analysis of indicator species reveals variability in the upper margin of the OMZ (528 m water depth) while the core of the OMZ (800 m) and below the OMZ (1175 m) remained stable in the last 1.5 kyr. We document expansion of the upper margin of the OMZ beginning 400 BP on the San Diego margin that is synchronous with other regional records of oxygenation.

ABSTRACTWe show a strong difference in surface mass and energy balance of a mountain glacier and two sites on the ice sheet at 64°N in West Greenland using stake and automated weather station observations. Net surface mass balance is on average 2.2 m w.e. less negative at the coast compared with the ice sheet in the same elevation. We find a larger energy turnover at the ice sheet margin on Qamanarssup Sermia than measured on the coastal mountain glacier Qassigiannguit with both energy input and output being of larger absolute value. More cloudiness and a thicker snow cover at the relatively humid coastal glacier result in smaller gains in net-shortwave radiation and smaller losses in net-longwave radiation and a less negative mass balance. Lower wind speeds at the coastal glacier result in weaker turbulent heat exchange between atmosphere and ice surface. On annual average, 17 W m−2more energy is available for melt at the ice-sheet margin compared with the coastal glacier in the same elevation.

Abstract We used satellite tags to monitor the movements of yellowfin tuna, blue marlin, and sailfish in the Palau National Marine Sanctuary (PNMS) and provide a first look into their use of this large-scale marine protected area (LSMPA). Tagged fish ranged over a wide geographic area between 1°S to 17°N and 125 to 154°W. Both blue marlin and sailfish exhibited fidelity to the PNMS; however, they dispersed more than 1000 km before returning. The monitoring periods of yellowfin tuna were insufficient to evaluate their long-term movements, but their dispersal from Palau's EEZ occurred in all directions, up to distances of 2010 km. The space use of this pelagic species assemblage overlapped with two bodies of international waters, six EEZs, and the Western and Central Pacific Fisheries Commission's management units seven and three of the western Pacific Ocean. Our results add to the knowledge base on the movements of pelagic species in the PNMS and highlight the need for additional research to determine the long-term movements of these species and the contribution of the PNMS to fisheries management in the western and central Pacific Ocean.

Abstract. Aerosol-induced increase of relative dispersion of cloud droplet size distribution ε exerts a warming effect and partly offsets the cooling of aerosol indirect radiative forcing (AIF) associated with increased droplet concentration by increasing the cloud droplet effective radius (Re) and enhancing the cloud-to-rain autoconversion rate (Au) (labeled as the dispersion effect), which can help reconcile global climate models (GCMs) with the satellite observations. However, the total dispersion effects on both Re and Au are not fully considered in most GCMs, especially in different versions of the Community Atmospheric Model (CAM). In order to accurately evaluate the dispersion effect on AIF, the new complete cloud parameterizations of Re and Au explicitly accounting for ε are implemented into the CAM version 5.1 (CAM5.1), and a suite of sensitivity experiments is conducted with different representations of ε reported in the literature. It is shown that the shortwave cloud radiative forcing is much better simulated with the new cloud parameterizations as compared to the standard scheme in CAM5.1, whereas the influences on longwave cloud radiative forcing and surface precipitation are minimal. Additionally, consideration of the dispersion effect can significantly reduce the changes induced by anthropogenic aerosols in the cloud-top effective radius and the liquid water path, especially in the Northern Hemisphere. The corresponding AIF with the dispersion effect considered can also be reduced substantially by a range of 0.10 to 0.21 W m−2 at the global scale and by a much bigger margin of 0.25 to 0.39 W m−2 for the Northern Hemisphere in comparison with that of fixed relative dispersion, mainly dependent on the change of relative dispersion and droplet concentrations (Δε∕ΔNc).

Glyptothorax siangensis, new species, is described from the Siang River in Arunachal Pradesh, India. The new species can be distinguished from its congeners from the Ganga-Brahmaputra drainage and its neighbouring drainages by the following combination of characters: a thoracic adhesive apparatus with skin ridges present over almost the entire apparatus, including the sword-shaped median depression, which is narrowly opened posteriorly; an elongated dorsal spine distinctly greater than body depth at its origin, posteriorly serrated with 11–17 serrae; nuchal plate saddle-like with W-shaped extensions; shallow body depth; long nasal barbel, almost reaching the anterior margin of eye; a complete longitudinal black band across the distal half of dorsal-fin; and tips of neural spines extension visible as a row of ridges between dorsal-fin base and origin of procurrent rays of caudal-fin. This is the nineteenth species of Glyptothorax known from the Ganga-Brahmaputra drainage.

Background:Children with juvenile idiopathic arthritis (JIA) have been found to have reduced cardiorespiratory fitness and lower physical activity. Poor cardiorespiratory fitness is associated with a risk of cardiometabolic diseases.Objectives:The aim of this study was to study the levels of cardiorespiratory fitness, respiratory function and hemodynamic responses during and after maximal cycle ergometer exercise test in children with JIA aged 6-17 years and compare the results with healthy controls.Methods:Study group in this analysis consisted of 43 patients with JIA who were treated in Department of Pediatrics in Kuopio University Hospital, Finland and 40 healthy age- and sex matched controls. Maximal exercise tests were carried out with an electromagnetic cycle ergometer using a pediatric saddle module. Maximal workload per kilogram (Wmax/kg) was used as a measure of cardiorespiratory fitness and was presented relative to bodyweight. In addition the peak values of VO2per kilogram (VO2max/kg) were used as a measure of highest amount of oxygen that an individual can consume during exercise. Values of VO2maxwere collected from respiratory gases measured directly from breath by breath method and was presented relative to body weight.Physical activity and sedentary behavior (minutes per day) was assessed by the PANIC (Physical activity and nutrition in children -study) Physical Activity Questionnaire which the participants filled.Results:Statistical analyses were performed for 43 children with JIA and 40 controls. Mean age in JIA group was 12.09 years (95%Cl 11.04-13.14), and 11.72 years (95%CI 10.52-12.93) in controls (p=0.572). Mean body mass index for age (BMI) was 22.58 kg/m2(95%CI 21.54-23.62) in JIA and 18.95 kg/m2(95%CI 17.73-20.16) in controls (p&lt;0.05). In JIA group BMI was 19.18 % higher compared to controls. Mean physical activity in JIA group was 94.11 minutes per day (95% Cl 81.09-107.13), and 122.54 minutes per day (95% CI 102.84-142.24) in controls, thus JIA group was 23.20 % less physically active than controls (p=0.015).Mean Wmax/kg was 2.65 W/kg (95% CI 2.49-2.82) in JIA and 3.01 W/kg (95%CI 2.86-3.15) in controls thus Wmax/kg in JIA was 0.36 W/kg (11.8 %) lower than in controls, (p = 0.002). VO2max/kg was 37.00 (95%CI 33.96-40.84) ml/kg/min in JIA and 43.30 (95%CI 40.79-45.82) ml/kg/min in controls thus in JIA group mean VO2max/kg was 6.3 ml/kg/min (14.4 %) lower than in controls (p=0.001).Conclusion:Children with JIA were found to have significantly lower cardiorespiratory fitness. In addition, BMI in JIA patients was higher compared to healthy age- and sex-matched controls. Impaired cardiorespiratory fitness and higher BMI may predispose children with JIA to cardiometabolic comorbidities later in life. In addition to disease-control, more attention should be paid to maintaining good cardiorespiratory fitness and normal BMI in these patients already before adulthood.References:[1]M Nørgaard, M Twilt, LB Andersen &amp; T Herlin (2016) Accelerometry-based monitoring of daily physical activity in children with juvenile idiopathic arthritis, Scandinavian Journal of Rheumatology, 45:3, 179-187,[2]Maggio, A.B.R., Hofer, M.F., Martin, X.E. et al. Reduced physical activity level and cardiorespiratory fitness in children with chronic diseases. Eur J Pediatr 169, 1187–1193 (2010)[3]Bohr, AH., Fuhlbrigge, R.C., Pedersen, F.K. et al. Premature subclinical atherosclerosis in children and young adults with juvenile idiopathic arthritis. A review considering preventive measures. Pediatr Rheumatol (2016)14: 3.Acknowledgments:Panu Karjalainen1, Timo Pitkänen1, Anneli Paloranta2, Kirsi Saastamoinen11University of Eastern Finland 2 Kuopio university hospital, FinlandDisclosure of Interests:None declared

Analysis of paleomagnetic data obtained from 1966 alternating-field treatment and from recent thermal demagnetization of the same samples of Late Proterozoic (770 Ma) diabase sills and dykes distributed about the Mackenzie Arc from northeastern British Columbia to the Alaskan border has revealed a primary magnetization in seven sites that is similar to existing data from 10 sites confined to the central Mackenzie Mountains region (N = 17 site poles; 222.2°W, 01.6°N; R = 16.73; K = 60; A95 = 5°). The diabases are confined to the dominantly clastic Late Proterozoic Tsezotene Formation and Katherine Group of the Mackenzie Mountains Supergroup. Tests of Carey's orocline hypothesis for the arc using linear regression and a plan-view application of the fold test suggest, in line with earlier structural studies, that the arc is largely nonrotational and that it is not an orocline resulting from the Cretaceous and early Tertiary Laramide Orogeny. Rather, it conforms to the arcuate foreland margin predating deposition of the Late Proterozoic Mackenzie Mountains Supergroup.

Background: This study evaluates the change in an MRI of the proximal metacarpal region in a group of sport horses that returned to work. This retrospective analysis evaluated 18 limbs represented by 17 horses. Results: The hyperintense signal within the dorsal collagenous part of the proximal suspensory ligament (PSL) on T1W/T2*W GRE sequences decreased or stayed the same in the majority of cases. The hyperintense STIR signal within the dorsal collagenous part of the PSL resolved in the majority of the patients, and the third metacarpal bone (McIII) hyperintense STIR signal resolved in all patients. The dorsal margin irregularity of the PSL stayed the same, and McIII sclerosis and resorption of the palmar margin of McIII stayed the same in the majority of cases. McIII hyperintense STIR signal resolution carries a broad time range, with a mean of 94 days and a range of 47–202 days. Conclusions: Complete normalization of the dorsal collagenous part of the PSL does not appear necessary for a return to soundness, but a resolution of the McIII hyperintense STIR signal is expected for horses returning to soundness. A rescan period of 120 days for the proximal metacarpal region is suggested. In addition, there was no significant change in the size of the PSL between the initial and final MRI.

An effective technique in the improvement of wear resistance and resource especially wornout friction is provided in the surface parts of anti-friction tribological coatings of various compositions entered in the regular lubrication maintenance of machines and equipment [1, 5, 7–10, 12–17]. Approved since 1930 [10] they during maintenance of machinery and equipment allows 2–3 times to increase their service life, 5–20 % reduced consumption of fuel and electricity, up to 30 % operating costs [7, 9, 10, 13, 14]. Introduction to oil chemically active substances, suspensions of particles of natural and artificial minerals, the oil solutions of the active organic substances, metal salts of organic acids [7, 17], the electric charge consumption less than 1 W [4, 6, 11], creating a wear-reducing coating [2, 5, 8, 12, 15–17], enhance adhesion of the lubricant is technically and economically justified, with a margin of 500–800 % or more [1, 3, 5, 7–10, 12–17]. CIP technical service as part of the overall system of technical maintenance and repair of machines, meets all the periods of their life cycle, and includes the testing, diagnosis, commissioning and preventive triboactive, the cleaning of the lubrication systems of engines, fuel, cooling, and most importantly — the restoration of worn units repair-regenerative trains [5, 7–10, 12–14, 17]. In the last intake of the mineral particles of the catalytically active open friction surface are subjected to a mechanical cold deformation, are involved in adhesion, physical and chemical processes, tribromoimidazole, catalysis of tribo-processes [2, 15–17]. As a result of the repair coating [2, 5, 12, 15–17]. The serpentine triboactive create a durable anti-friction coatings [2, 15–17]. According to research by European and American researchers [15, 16], especially in Chinese state laboratory of Tribology of Tsinghua University [17], these minerals cause the formation of diamondlike carbon fi lms (Diamond-Like carbon fi lms — DLC-fi lms). Their surface is high purity and hardness, underneath are visible traces of mechanical processing, for 90 % consist of carbon, the resistance of 10–300 Ohm/cm. The eff ect of serpentine processing is manifested through the hours and ability to operate even without triboactive [2, 10]. Below are the laboratory tribotechnical tests of triboactive and fi ling of charges in the oil, which confi rm the eff ectiveness of non-traditional tribology.

Abstract. We demonstrate, for the first time, continuous real-time observations of airborne bio-fluorescent aerosols recorded at the British Antarctic Survey's Halley VI Research Station, located on the Brunt Ice Shelf close to the Weddell Sea coast (lat 75°34′59′′ S, long 26°10′0′′ W) during Antarctic summer, 2015. As part of the NERC MAC (Microphysics of Antarctic Clouds) aircraft aerosol cloud interaction project, observations with a real-time ultraviolet-light-induced fluorescence (UV-LIF) spectrometer were conducted to quantify airborne biological containing particle concentrations along with dust particles as a function of wind speed and direction over a 3-week period. Significant, intermittent enhancements of both non- and bio-fluorescent particles were observed to varying degrees in very specific wind directions and during strong wind events. Analysis of the particle UV-induced emission spectra, particle sizes and shapes recorded during these events suggest the majority of particles were likely a subset of dust with weak fluorescence emission responses. A minor fraction, however, were likely primary biological particles that were very strongly fluorescent, with a subset identified as likely being pollen based on comparison with laboratory data obtained using the same instrument. A strong correlation of bio-fluorescent particles with wind speed was observed in some, but not all, periods. Interestingly, the fraction of fluorescent particles to total particle concentration also increased significantly with wind speed during these events. The enhancement in concentrations of these particles could be interpreted as due to resuspension from the local ice surface but more likely due to emissions from distal sources within Antarctica as well as intercontinental transport. Likely distal sources identified by back trajectory analyses and dispersion modelling were the coastal ice margin zones in Halley Bay consisting of bird colonies with likely associated high bacterial activity together with contributions from exposed ice margin bacterial colonies but also long-range transport from the southern coasts of Argentina and Chile. Dispersion modelling also demonstrated emissions from shipping lanes, and therefore marine anthropogenic sources cannot be ruled out. Average total concentrations of total fluorescent aerosols were found to be 1.9 ± 2.6 L−1 over a 3-week period crossing over from November into December, but peak concentrations during intermittent enhancement events could be up to several tens per litre. While this short pilot study is not intended to be generally representative of Antarctic aerosol, it demonstrates the usefulness of the UV-LIF measurement technique for quantification of airborne bioaerosol concentrations and to understand their dispersion. The potential importance for microbial colonisation of Antarctica is highlighted.

The structure of the transition zone between the north-western boundary of the Congo Craton and the Kribi-Campo sedimentary basin is still a matter of scientific debate. In this study, the existing gravity data are interpreted in order to better understand the geodynamics of the area. Qualitatively, results show that the major gravity highs are associated with long-wavelength shallow sources of the coastal sedimentary basin, while large negative anomalies trending E-W correlate to low dense intrusive bodies found along the northern limit of the Congo Craton. For the delineation of the causative sources, the gravity anomalies have been inverted based on the Parker-Oldenburg iterative process. As inputs, we used a reference depth of 20 km obtained by spectral analysis and successively, the density contrasts 0.19 g/cm3 and 0.24 g/cm3, deduced from available 1D shear wave velocity models. The results reveal an irregular topography of the mafic interface characterized by a sequence of horst and graben structures with mafic depths varying between 15.6 km and 23.4 km. The shallower depths (15.6-17 km) are associated with the uprising of the mafic interface towards the upper crust. This intrusion may have been initiated during the extension of the Archean Ntem crust resulting in a thinning of the continental crust beneath the coastal sedimentary basin. The subsidence of the mafic interface beneath the craton is materialized by 2 similar graben structures located beneath both Matomb and Ebolowa at a maximum depth of 23.4 km. The intermediate depths (18-22 km) are correlated to the suture zone along the Pouma-Bipindi area. The location of some landslides across the area matches within the northern margin of the Congo Craton and suggests that this margin may also impact on their occurrence. This work provides new insights into the geodynamics, regional tectonics, and basin geometry.

ResumenEl presente trabajo tiene por propósito exponer el modo en que las redes sociales (Facebook, Instagram, Twitter, etc.), constituyen lo que llamamos aquí “habitar web”. Retomando de forma parcial los planteamientos de Heidegger, Marx y Han, y poniendo la vista a la par en The Matrix, mostraremos que el “habitar web” es un modo del habitar fundado en el desarrollo de la técnica moderna, caracterizado, primero, por la transparencia y, segundo, por ser un modo histórico específico de enajenación que oculta el mundo de la vida.&#x0D; Palabras clave Redes sociales; Habitar; Enajenación; Transparencia, Mundo de la vida.&#x0D; Referencias&#x0D; Benjamin, Walter, “Kapitalismus als Religion” en: Gesammelte Schriften (Band 7), ed. Rolf Tiedemann &amp; Hermann Schweppenhäuser, Frankfurt am Main: Suhrkamp, 1991, 100-102.&#x0D; Han, Byung-Chul, La sociedad de la transparencia, trad. Raúl Gabás, Barcelona: Herder, 2013.&#x0D; Han, Byung-Chul, Psicopolítica, trad. Alfredo Bergés, Barcelona: Herder, 2014.&#x0D; Han, Byung-Chul, El enjambre, trad. Raúl Gabás, Barcelona: Herder, 2014.&#x0D; Heidegger, Martin, Prolegomena zur Geschichte des Zeitbegriffes (GA 20), ed. Petra Jaeger, Frankfurt am Main: Vittorio Klostermann, 1979.&#x0D; Heidegger, Martin, Aus der Erfahrung des Denkens (GA 13), ed. Hermann Heidegger, Frankfurt am Main: Vittorio Klostermann, 1983.&#x0D; Heidegger, Martin, “La pregunta por la técnica”, en Conferencias y Artículos, trad. Eustaquio Barjau, Barcelona: Serbal, 1994, 9-38.&#x0D; Heidegger, Martin, Ser y tiempo, trad. Jorge Eduardo Rivera, Santiago de Chile: Editorial Universitaria, 1997.&#x0D; Heidegger, Martin, “Bauen Wohnen Denken”, en Vorträge und Aufsätze (GA 7), ed. F.W. von Herrmann (Frankfurt am Main: Vittorio Klostermann, 2000, 145-164.&#x0D; Heidegger, Martin, “Wissenschaft und Besinnung”, en Vorträge und Aufsätze (GA 7), F.-W. von Herrmann, Frankfurt am Main: Vittorio Klostermann, 2000, 37-66.&#x0D; Heidegger, Martin, Serenidad, trad. Ives Zimmermann, Barcelona: Serbal, 2002. Husserl, Edmund, Die Krisis der europäischen Wissenschaften und die transzendentale Phänomenologie (Hua VI), ed. Walter Biemel, Den Haag: Martinus Nijhof, 1954.&#x0D; Kant, Immanuel, Grundlegung zur Metaphysik der Sitten, Hamburg: Meiner, 1965.&#x0D; Kracauer, Siegfried, “La crisis de las ciencias”, en Estética sin territorio, trad. Vincente Jarque, Murcia: Consejería de Educación y Cultura de la Región de Murcia, 2006, 157-172.&#x0D; Löwy, Michael,“Capitalism as Religion: Walter Benjamin and Max Weber”, en Historical Materialism 17, (2009): 60-73.&#x0D; Mackay, Hamish, “¿Cuánto dinero ganan realmente los ‘influencers’ como Kylie Jenner en Instagram?”, BBC News Online, 4 de Octubre, 2018, https://www. bbc.com/mundo/noticias-45746922 Marcuse, Herbert, One-dimensional man, New York-London: Routledge, 2002.&#x0D; Marx, Karl &amp; Friedrich Engels, “Zur Kritik der Hegelschen Rechtsphilosophie. Einleitung”, en Marx-Engels Werke (MEW 1), ed. Institut für Marxismus-Leninismus, Berlin: Dietz, 1981, 378-391.&#x0D; Marx, Karl &amp; Friedrich Engels, “Zur Judenfrage”, en Marx-Engels Werke (MEW 1), ed. Institut für Marxismus-Leninismus, Berlin: Dietz, 1981, 347-377.&#x0D; Orejarena, Jean, “Heidegger y Hölderlin: Una investigación acerca del sentido del habitar en la época moderna”, Tesis de Maestría, Benemérita Universidad Autónoma de Puebla, 2014.&#x0D; Ponzi, Mauro, Nietzsche’s Nihilism in Walter Benjamin, New York-London: Palgrave Macmillan, 2017. Xolocotzi, Ángel, Fundamento y abismo. Aproximaciones al Heidegger tardío, México: Miguel Ángel Porrúa/BUAP, 2011.

Abstract The study was conducted in 2007 with the inquiry method in 30 farms which specialised in livestock production based on own grasslands and participated in the Rural Development Programme in the years 2004-2006. The mean farm area was 19.69 ha (from 2.2 ha to182.0 ha) and farms were divided into 4 groups: 1-10; 10-20; 20-50 and &gt;50 ha. The share of permanent grasslands was 53.8% on average. The crop structure was subject to the production of bulk feeds and feed grain (oats), cereal mixtures, triticale and barley. The mean share of cereals was 78.5 %, root crops - 9.4 % and legumes - 2.1 %. The highest livestock (cattle, pigs, horses, poultry) density (mean of 0.5 LU per ha of agricultural land) was in farms from the group of 20-50 ha. Both the farm investments in fixed assets and average direct costs of plant and animal production were low. The revenue from agricultural production was medium to low. The proportion of subsidies from the RDP was high (17%). Gross margin in farms was medium and low. Its value per 1 ha of agricultural land (AL) and per capita increased with the increase of farm surface area (except for a group of 20.1-50.0 ha). The effectiveness of fixed assets was high, its index ranged from 0.39 to 0.58 with a mean of 0.43. Only 23% of surveyed farms had a chance of further development.

The performance, energy storage capacity, safety, and lifetime of lithium-ion battery cells of different chemistries are very sensitive to operating and environmental temperatures. The cells generate heat by current passing through their internal resistances, and chemical reactions can generate additional, sometimes uncontrollable, heat if the temperature within the cells reaches the trigger temperature. Therefore, a high-performance battery cooling system that maintains cells as close to the ideal temperature as possible is needed to enable the highest possible discharge current rates while still providing a sufficient safety margin. This paper presents a novel design, preliminary development, and results for an inexpensive reusable, liquid-cooled, modular, hexagonal battery module that may be suitable for some mobile and stationary applications that have high charge and or discharge rate requirements. The battery temperature rise was measured experimentally for a six parallel 18650 cylindrical cell demonstrator module over complete discharge cycles at discharge rates of 1C, 2C and 3C. The measured temperature rises at the hottest point in the cells, at the anode terminal, were found to be 6, 17 and 22 °C, respectively. The thermal resistance of the system was estimated to be below 0.2 K/W at a coolant flow rate of 0.001 Kg/s. The proposed liquid cooled module appeared to be an effective solution for maintaining cylindrical Li-ion cells close to their optimum working temperature.

351 Background: Neoadjuvant therapy is recommended to increase the likelihood of margin-negative (R0) resection for BRPC. However, there is no consensus regarding the optimal treatment paradigm, including the respective roles of chemotherapy and radiation (RT), in this setting. Methods: Retrospective analysis was conducted of BRPC pts treated with neoadjuvant FOLFIRINOX followed by surgical resection at a single tertiary care referral center over a 4-year period. Data collected included baseline pt characteristics, toxicity profiles, radiographic and serum CA19-9 response, perioperative complication rate, R0 resection rate, histopathologic response, and frequency and patterns of recurrence. Results: 26 BRPC pts received neoadjuvant FOLFIRINOX, 22 w/o addn RT. Abutment of the SMV (n = 9, 40.9%), SMA (n = 4, 18.2%), CHA (n = 4, 18.2%), and narrowing of the SMV (n = 4, 18.2%) were the most common vascular involvement. 9 (40.9%) pts had both arterial and venous involvement. Median baseline CA19-9 level was 278.5 U/ml. Pts received a median of 9 treatment cycles (range, 4-12). Radiographic response was categorized as shrinkage (n = 11, 50%), stable (n = 9, 40.9%), or progression (n = 2, 9.1%). The Whipple procedure was the most common operation performed (n = 17, 77.3%), with 12 pts (54.5%) requiring vascular reconstruction. Clavien-Dindo complication rates of grade 0, I, II, and IIIa occurred in 25.9%, 11.1%, 44.4%, and 14.8% of pts, respectively. R0 resection rate was 90.9%, with 13 (59.1%) having negative lymph nodes. Treatment response of Evans grade III or IV, corresponding to &lt; 10% residual tumor cells, was seen in 8 pts (36.4%), including one pathologic CR (4.5%). AJCC Stage: ypT3N0 (36.4%), ypT3N1 (18.2%), ypT1N1 (18.2%). With a median f/u time of 22.1 months, 8 pts (36.4%) have progressed, inc 7 (87.5%) with distant disease. Median PFS is 22.5 mos. Conclusions: This is one of the largest series to report on the use of neoadjuvant chemotherapy w/o RT in BRPC pts. FOLFIRINOX alone in this setting is associated with high R0 resection rates and favorable clinical outcomes, and should be further assessed in prospective study design for BRPC.

Booth, John, Michael J. McKenna, Patricia A. Ruell, Tom H. Gwinn, Glen M. Davis, Martin W. Thompson, Alison R. Harmer, Sandra K. Hunter, and John R. Sutton. Impaired calcium pump function does not slow relaxation in human skeletal muscle after prolonged exercise. J. Appl. Physiol. 83(2): 511–521, 1997.—This study examined the effects of prolonged exercise on human quadriceps muscle contractile function and homogenate sarcoplasmic reticulum Ca2+ uptake and Ca2+-adenosinetriphosphatase activity. Ten untrained men cycled at 75 ± 2% (SE) peak oxygen consumption until exhaustion. Biopsies were taken from the right vastus lateralis muscle at rest, exhaustion, and 20 and 60 min postexercise. Peak tension and half relaxation time of the left quadriceps muscle were measured during electrically evoked twitch and tetanic contractions and a maximal voluntary isometric contraction at rest, exhaustion, and 10, 20, and 60 min postexercise. At exhaustion, homogenate Ca2+ uptake and Ca2+ adenosinetriphosphatase activity were reduced by 17 ± 4 and 21 ± 5%, respectively, and remained depressed after 60 min recovery ( P ≤ 0.01). Muscle ATP, creatine phosphate, and glycogen were all depressed at exhaustion ( P ≤ 0.01). Peak tension during a maximal voluntary contraction, a twitch, and a 10-Hz stimulation were reduced after exercise by 28 ± 3, 45 ± 6, 65 ± 5%, respectively ( P ≤ 0.01), but no slowing of half relaxation times were found. Thus fatigue induced by prolonged exercise reduced muscle Ca2+ uptake, but this did not cause a slower relaxation of evoked contractions.

ABSTRACTFoliated to massive hornblende and biotite-bearing tonalite, trondhjemite and granodiorite comprise a terrane of batholithic dimensions in southwestern to central Newfoundland. These rocks intrude and include Ordovician ophiolite fragments and metasedimentary rocks of Fleur de Lys type, and are cut by a suite of Silurian gabbro-diorite and norite and Siluro-Devonian (?) granite intrusions.A U/Pb (zircon, sphene) age of 456 ± 3 Ma (2σ) and a K/Ar (hornblende) age of 455 ± 14 Ma (previously reported) for a representative least-deformed tonalite of the Southwest Brook Complex indicate that it crystallised and cooled in Caradoc time. A less precise U/Pb (zircon) age of 428 ± 41 Ma (2σ) is measured for tonalitic Cape Ray Granite in southern Newfoundland. On discrimination diagrams which use Rb, Nb and Y contents to infer tectonic setting, these rocks fall in the field of volcanic arc granites. The occurrence of zircon cores with average ages of 1430 + 18/–17 and 1541 ± 173 Ma (2σ) also indicate that the magmas formed in part by partial melting of Proterozoic crust, or sediments derived from such crust. It is suggested that the tonalitic magmas were generated during the Taconic Orogeny in an arc: continent collision zone at the ancient margin of eastern North America.Tonalitic rocks in western Newfoundland broadly correlative in age and chemistry with the batholith include the Burlington Granodiorite and Hungry Mountain Complex, as well as allochthonous slices of foliated tonalite emplaced over Ordovician platform carbonates W of Grand Lake.

European hackberry (Celtis australis L.) is a popular shade tree mainly planted in southern Europe and known to be tolerant to dry and poor soils. In early autumn 2013, hackberry plants grown in soil in a commercial nursery located in the floodplain in Umbria region showed symptoms of wilting, dieback, and death. Up to 100% of the canopy was affected, and over 60% of the plants were symptomatic or dead. A Phytophthora species was consistently isolated from symptomatic 6-year-old plants by plating small pieces of collar and root tissues, cut from the margin of dark-brown necrotic lesions, onto P5ARPH selective medium (4). Pure cultures were obtained by single-hyphal transfers on potato dextrose agar (PDA). Sporangia, produced on pepper seeds in soil extract solution (3), were nonpapillate and noncaducous, measuring 34.0 to 85.0 × 22.0 to 50.0 μm. Oospores had an average diameter of 44 μm with mostly paragynous antheridia. On the basis of morphological features, the isolates were identified as P. megasperma Drech. (2). The identity was confirmed by sequencing the cytochrome c oxidase subunit II (Cox II) (5), which gave 100% identity with P. megasperma sequences available in GenBank (GU222070), and by sequencing the internal transcribed spacer (ITS) using the universal primers ITS4 and ITS6, which gave 99% identity with the AF266794 sequence from Cooke et al. (1). The sequences of one isolate (AB239) were deposited in the European Nucleotide Archive (ENA) with accession numbers HG973451 and HG973450 for Cox II and ITS, respectively. Pathogenicity tests were conducted in the greenhouse with isolate AB239 on eight 2-year-old potted European hackberry plants. Mycelial plugs (5 mm diameter) cut from the margins of actively growing 8-day-old cultures on PDA were inserted through the epidermis to the phloem at the collar level. Two plants were used as controls and treated as described above except that sterile PDA plugs replaced the inoculum. Inoculated plants were kept for 4 weeks in a greenhouse at 24 ± 2°C. During that period, inoculated plants showed wilting symptoms similar to those observed in the field. Lesions were evident at all the inoculation points progressing downward to the roots. Colonies of Phytophthora were isolated from the margins of lesions and identified as P. megasperma, thus fulfilling Koch's postulates. Controls remained symptomless. P. megasperma taxonomy is rather complex since it embraces different subgroups, including host specialized forms (formae speciales), some of which are recognized as biological species. Based on morphological and molecular data presented here, the Phytophthora isolates from hackberry belong to P. megasperma sensu stricto, which is included in the “pathogenic to a broad range of hosts” (BHR) group (1). This pathogen is rather polyphagous, attacking mainly fruit and ornamental woody plants, commonly Prunus spp., Malus spp., and Actinidia deliciosa. Like other homothallic Phytophthora species, it is particularly dangerous due to its abundant production of thick-walled resting oospores that enable long-term survival in the soil. To our knowledge this is the first report of P. megasperma sensu stricto (1) on C. australis and its family Ulmaceae/Cannabaceae. References: (1) D. E. L. Cooke et al. Fungal Genet. Biol. 30:17, 2000. (2) D. C. Erwin and O. K. Ribeiro, American Phytopathological Society, St. Paul, MN, 1996. (3) E. Ilieva et al. Eur. J. Plant Path. 101:623, 1995. (4) S. N. Jeffers and S. B. Martin. Plant Dis. 70:1038, 1986. (5) F. N. Martin and P. W. Tooley. Mycologia 95:269, 2003.

Abstract. The South Atlantic rift basin evolved as branch of a large Jurassic-Cretaceous intraplate rift zone between the African and South American plates during the final breakup of western Gondwana. While the relative motions between South America and Africa for post-breakup times are well resolved, many issues pertaining to the fit reconstruction and particular the relation between kinematics and lithosphere dynamics during pre-breakup remain unclear in currently published plate models. We have compiled and assimilated data from these intraplated rifts and constructed a revised plate kinematic model for the pre-breakup evolution of the South Atlantic. Based on structural restoration of the conjugate South Atlantic margins and intracontinental rift basins in Africa and South America, we achieve a tight fit reconstruction which eliminates the need for previously inferred large intracontinental shear zones, in particular in Patagonian South America. By quantitatively accounting for crustal deformation in the Central and West African rift zone, we have been able to indirectly construct the kinematic history of the pre-breakup evolution of the conjugate West African-Brazilian margins. Our model suggests a causal link between changes in extension direction and velocity during continental extension and the generation of marginal structures such as the enigmatic Pre-salt sag basin and the São Paulo High. We model an initial E–W directed extension between South America and Africa (fixed in present-day position) at very low extensional velocities until Upper Hauterivian times (≈126 Ma) when rift activity along in the equatorial Atlantic domain started to increase significantly. During this initial ≈17 Myr-long stretching episode the Pre-salt basin width on the conjugate Brazilian and West African margins is generated. An intermediate stage between 126.57 Ma and Base Aptian is characterised by strain localisation, rapid lithospheric weakening in the equatorial Atlantic domain, resulting in both progressively increasing extensional velocities as well as a significant rotation of the extension direction to NE–SW. From Base Aptian onwards diachronous lithospheric breakup occurred along the central South Atlantic rift, first in the Sergipe-Alagoas/Rio Muni margin segment in the northernmost South Atlantic. Final breakup between South America and Africa occurred in the conjugate Santos–Benguela margin segment at around 113 Ma and in the Equatorial Atlantic domain between the Ghanaian Ridge and the Piauí-Ceará margin at 103 Ma. We conclude that such a multi-velocity, multi-directional rift history exerts primary control on the evolution of this conjugate passive margins systems and can explain the first order tectonic structures along the South Atlantic and possibly other passive margins.

176 Background: AA is a standard of care for the treatment of metastatic CRPC, with an approximate retail cost of $8000/month. Despite a large food effect (~17-fold increase in CMax with a high-fat meal), AA was administered under fasting conditions in its pivotal trials. There are no randomized continuous dosing studies examining prandial state dosing on AA PK/PD. We sought to test the hypothesis that LOW (250mg w/food) would have similar PK/PD and safety to standard (STD, 1000mg fasting) in patients with progressive CRPC. Methods: Patients (n = 72) with progressive CRPC from seven institutions in the US and Singapore were randomized to treatment with STD or LOW (with low-fat breakfast). Both arms received prednisone 5mg twice daily. PSA was assessed monthly, and testosterone, DHEA/DHEAS were assessed every 12 weeks along with standard disease burden assessments. PK samples were collected at day 1, 8 and months 2, 3, 4. Log change in PSA response rate from baseline to week 12 was examined as the primary endpoint, with a non-inferiority design based on a non-inferiority margin of 15%. This margin corresponds to a 0.51 standard deviation (SD) difference in the mean log changes between the groups. Results: Accrual was completed with n = 36 on STD and n = 36 on LOW. Median (range) age was 74 (52-89) and baseline PSA was 39.2(range 0.6-1789). Mean log-change in PSA at 12 weeks was nominally greater in the LOW arm (-1.59 vs. -1.19). The 95% confidence for the difference (STD-LOW) ranged from -0.40 to 1.19, with lower limit corresponding to -0.24SD. Thus, non-inferiority of LOW was established. Median time to PSA progression was ~14 month in both arms (p = 0.53). Preliminary analysis of PK showed no difference in CMaxbeyond the first cycle with lower PK variability in the LOW arm. Conclusions: Low-dose (250mg/day) abiraterone acetate with a low-fat breakfast is non-inferior to standard dosing in a fasted state with respect to PSA and PK metrics. Although PSA response and progression are not clinically validated surrogates, given the pharmacoeconomic implications, these data warrant consideration by prescribers and payors. Clinical trial information: NCT01543776.

Combining spectroscopy with electrochemistry enables the monitoring of changes in bonding, molecular orientation, and chemical composition during electrochemical processes at the electrode/electrolyte interface. Surface-enhanced infrared absorption spectroscopy (ATR-SEIRAS) allows a direct in situ monitoring of electrochemical processes occurring at the electrode interface due plasmonic enhancement by surface plasmon polaritons (SPP).1 Electrochemical ATR-SEIRAS has been used extensively for investigating electrocatalysis2,3, characterizing adsorbed species4, and detecting reaction intermediates5. However, SEIRAS literature has focused on plasmonic metals while the small number of SEIRAS studies reported on graphene surfaces are incompatible with electrochemical experimentation or not considered. Nonetheless, carbon electrodes are ubiquitous in electrocatalysis, sensing, and energy storage6, thus probing their surface chemistries are of particular interest. Thus, there is still a need for a convenient substrate for probing graphitic interfaces using electrochemical SEIRAS. In our first study1, we expanded the scope of SEIRAS by introducing a robust hybrid graphene on gold (graphene-gold) substrate where we monitored electrografting processes occurring on the graphene/electrolyte interface. The graphene-gold substrate successfully monitored the electrografting of 2,2,6,6-tetremethyl-1-pipperridine N-oxyl (4-amino-TEMPO) and 4-nitrobenzene diazonium (4-NBD) in real-time using SEIRAS and cyclic voltammetry. The graphene-gold substrate is proficient at resolving the spectral responses of the electrografting and redox transformations of the grafted moieties occurring at the graphene interface spectroscopically and electrochemically. We clearly demonstrate highly sensitive SEIRAS in real-time at a graphene interface. This substrate opens a plethora of possibilities for real-time electrochemical ATR-SEIRAS investigations on graphitic interfaces such as catalysis, battery research, and CO2 capture and conversion, the latter of which our laboratory is exploring using modified electrodes. Electrochemical carbon capture and concentration (eCCC) methods have emerged as a prosing alternative to the current state-of-the-art temperature-pressure swing systems.7 Redox-active organic (RAO) molecules such as quinones have been reported to reversibly capture and release CO2. 7 However, they suffer from low solubility in solution. New approaches have explored immobilizing these molecules on electrode interfaces for increased CO2 adsorption capacities.11 Our graphene-gold allows a unique opportunity for an in situ mechanistic investigation of the immobilization and carbonization of RAOs. Our current work investigating immobilized aminoanthraquinone and a riboflavin derivative will be presented. References: (1) Siddiqui, A.-R.; N’Diaye, J.; Martin, K.; Baby, A.; Dawlaty, J.; Augustyn, V.; Rodríguez-López, J. Monitoring SEIRAS on a Graphitic Electrode for Surface-Sensitive Electrochemistry: Real-Time Electrografting. Anal. Chem. 2024, 96 (6), 2435–2444. https://doi.org/10.1021/acs.analchem.3c04407. (2) Jiang, T.-W.; Qin, X.; Ye, K.; Zhang, W.-Y.; Li, H.; Liu, W.; Huo, S.; Zhang, X.-G.; Jiang, K.; Cai, W.-B. An Interactive Study of Catalyst and Mechanism for Electrochemical CO2 Reduction to Formate on Pd Surfaces. Appl. Catal. B Environ. 2023, 334, 122815. https://doi.org/10.1016/j.apcatb.2023.122815. (3) Li, T.; Han, S.; Wang, Y.; Zhou, J.; Zhang, B.; Yu, Y. A Spectroscopic Study on Nitrogen Electrooxidation to Nitrate. Angew. Chem. Int. Ed. 2023, 62 (19), e202217411. https://doi.org/10.1002/anie.202217411. (4) Siddiqui, A.-R.; N’Diaye, J.; Santiago-Carboney, A.; Martin, K.; Bhargava, R.; Rodríguez-López, J. Spectroelectrochemical Determination of Thiolate Self-Assembled Monolayer Adsorptive Stability in Aqueous and Non-Aqueous Electrolytes. Analyst 2024. https://doi.org/10.1039/D4AN00241E. (5) Pang, L.; Zhao, Z.; Ma, X.-Y.; Cai, W.-B.; Guo, L.; Dong, S.; Liu, C.; Peng, Z. Hyphenated DEMS and ATR-SEIRAS Techniques for in Situ Multidimensional Analysis of Lithium-Ion Batteries and Beyond. J. Chem. Phys. 2023, 158 (17), 174701. https://doi.org/10.1063/5.0144635. (6) Kothandam, G.; Singh, G.; Guan, X.; Lee, J. M.; Ramadass, K.; Joseph, S.; Benzigar, M.; Karakoti, A.; Yi, J.; Kumar, P.; Vinu, A. Recent Advances in Carbon-Based Electrodes for Energy Storage and Conversion. Adv. Sci. 2023, 10 (18), 2301045. https://doi.org/10.1002/advs.202301045. (7) Zito, A. M.; Clarke, L. E.; Barlow, J. M.; Bím, D.; Zhang, Z.; Ripley, K. M.; Li, C. J.; Kummeth, A.; Leonard, M. E.; Alexandrova, A. N.; Brushett, F. R.; Yang, J. Y. Electrochemical Carbon Dioxide Capture and Concentration. Chem. Rev. 2023, 123 (13), 8069–8098. https://doi.org/10.1021/acs.chemrev.2c00681. (8) Karamé, I.; Shaya, J.; Srour, H.; Vega, F.; Cano, M.; Camino, S.; GallegoFernández, L. M.; Portillo, E.; Navarrete, B. Carbon Dioxide Chemistry, Capture and Oil Recovery. In Carbon Dioxide Chemistry, Capture and Oil Recovery; IntechOpen, 2018. https://doi.org/10.5772/intechopen.68466. (9) Keith, D. W.; Holmes, G.; St. Angelo, D.; Heidel, K. A Process for Capturing CO2 from the Atmosphere. Joule 2018, 2 (8), 1573–1594. https://doi.org/10.1016/j.joule.2018.05.006. (10) Stampi-Bombelli, V.; van der Spek, M.; Mazzotti, M. Analysis of Direct Capture of CO2 from Ambient Air via Steam-Assisted Temperature–Vacuum Swing Adsorption. Adsorption 2020, 26 (7), 1183–1197. https://doi.org/10.1007/s10450-020-00249-w. (11) A. Hartley, N.; M. Pugh, S.; Xu, Z.; Y. Leong, D. C.; Jaffe, A.; C. Forse, A. Quinone-Functionalised Carbons as New Materials for Electrochemical Carbon Dioxide Capture. J. Mater. Chem. A 2023, 11 (30), 16221–16232. https://doi.org/10.1039/D3TA02213G. Figure 1

Abstract The pleiotropic roles of nSMase2-generated ceramide include regulation of intracellular ceramide signaling and exosome biogenesis. We investigated the effects of eliminating nSMase2 on early and advanced PDA, including its influence on the microenvironment. Employing the KPC mouse model of pancreatic cancer, we demonstrate that pancreatic epithelial nSMase2 ablation reduces neoplasia and promotes a PDA subtype switch from aggressive basal-like to classical. nSMase2 elimination prolongs survival of KPC mice, hinders vasculature development, and fosters a robust immune response. nSMase2 loss leads to recruitment of cytotoxic T cells, N1-like neutrophils, and abundant infiltration of anti-tumorigenic macrophages in the pancreatic preneoplastic microenvironment. Mechanistically, we demonstrate that nSMase2-expressing PDA cell small extracellular vesicles (sEVs) reduce survival of KPC mice; PDA cell sEVs generated independently of nSMase2 prolong survival of KPC mice and reprogram macrophages to a proinflammatory phenotype. Collectively, our study highlights previously unappreciated opposing roles for exosomes, based on biogenesis pathway, during PDA progression. Citation Format: Audrey M Hendley, Sudipta Ashe, Atsushi Urano, Martin Ng, Tuan A Phu, Xianlu Laura Peng, Changfei Luan, Anna-Marie Finger, Gun Ho Jang, Natanya R Kerper, David I Berrios, David Jin, Jonghyun Lee, Irene R Riahi, Oghenekevwe M Gbenedio, Christina Chung, Jeroen P Roose, Jen Jen Yeh, Steven Gallinger, Andrew V Biankin, Grainne M O’Kane, Vasilis Ntranos, David K Chang, David W Dawson, Grace E Kim, Valerie M Weaver, Robert L Raffai, Matthias Hebrok. nSMase2-mediated exosome secretion shapes the tumor microenvironment to immunologically support pancreatic cancer [abstract]. In: Proceedings of the AACR Special Conference in Cancer Research: Advances in Pancreatic Cancer Research; 2024 Sep 15-18; Boston, MA. Philadelphia (PA): AACR; Cancer Res 2024;84(17 Suppl_2):Abstract nr A066.

&lt;p&gt;Transition metal complexes, including &lt;em&gt;copper(II) complexes&lt;/em&gt;, are being investigated as potential next-generation antibacterial agents. This study aims to prepare several &lt;em&gt;Cu(II)-pyrazinamide&lt;/em&gt; (&lt;em&gt;Cu(II)-pza&lt;/em&gt;) complexes using &lt;em&gt;Cu(II)&lt;/em&gt; salts (acetate, chloride, nitrate, sulphate) through a direct mixing technique. Different &lt;em&gt;Cu(II)&lt;/em&gt; salts are anticipated to yield distinct complexes, resulting in varied antibacterial properties. The &lt;em&gt;Cu(II)-pza&lt;/em&gt; complexes were characterized using melting point analysis, infrared spectroscopy, and powder X-ray diffraction (XRD). Melting point analysis provides insights into the physical properties of the complexes. Infrared spectroscopy identifies functional groups and predicts chemical bonds within the complexes. Powder XRD analyzes the characteristic diffraction patterns of the complexes. Experimental data reveal that the infrared spectra of all &lt;em&gt;Cu(II)-pza&lt;/em&gt; complexes exhibit typical absorption bands of the pyrazinamide ligand (N-H, C=O, C-N, and C=N). Powder XRD analysis shows different diffraction patterns for each complex, indicating the formation of different compounds due to variations in anion and metal-ligand interactions, with the sulphate complex matching a previously reported complex. Melting point tests indicate the decomposition of the complexes within the range of 215–225 °C, except for the acetate complex, which decomposes at 275 °C. The antibacterial activities of these complexes against &lt;em&gt;S. aureus&lt;/em&gt; and &lt;em&gt;E. coli&lt;/em&gt; were examined in vitro based on inhibition zone diameter and MIC value. The sulphate, nitrate, and chloride complexes exhibit MIC values of 1,000 ppm and MBC values of 6,000 ppm, demonstrating better antibacterial activity against &lt;em&gt;S. aureus&lt;/em&gt; than &lt;em&gt;E. coli&lt;/em&gt;. These findings suggest the potential of &lt;em&gt;Cu(II)-pza&lt;/em&gt; complexes as antibacterial agents. Further studies, such as crystal structure determination, are necessary to explore the possible mechanisms of antibacterial activity.&lt;/p&gt;&lt;p class="MsoNormal" style="margin-top: 0cm; margin-right: 0cm; margin-bottom: 6.0pt; margin-left: 1.0cm; text-indent: -1.0cm; line-height: 115%; text-autospace: none;"&gt;&lt;span style="font-size: 10.0pt; line-height: 115%; font-family: 'Arial',sans-serif; mso-ansi-language: EN-ID;"&gt;[1] N. C. Handayani, A. Kusuma, R. Purwanto, R. E. Prasetya, and A. Budiman, “Pengembangan Agen Potensi Pengembangan Agen Antibakteri dari Senyawa Kompleks Logam Transisi di Indonesia,” The Indonesian Green Technology Journal, vol. 10, no. 1, pp. 9-20, 2021.&lt;/span&gt;&lt;/p&gt;&lt;p class="MsoNormal" style="margin-top: 0cm; margin-right: 0cm; margin-bottom: 6.0pt; margin-left: 1.0cm; text-indent: -1.0cm; line-height: 115%; text-autospace: none;"&gt;&lt;span style="font-size: 10.0pt; line-height: 115%; font-family: 'Arial',sans-serif; mso-ansi-language: EN-ID;"&gt;[2] R. S. Hellberg and E. Chu, “Effects of climate change on the persistence and dispersal of foodborne bacterial pathogens in the outdoor environment: A review,” Crit. Rev. Microbiol., vol. 42, no. 4, pp. 548–572, 2016. doi: 10.3109/1040841X.2014.967385.&lt;/span&gt;&lt;/p&gt;&lt;p class="MsoNormal" style="margin-top: 0cm; margin-right: 0cm; margin-bottom: 6.0pt; margin-left: 1.0cm; text-indent: -1.0cm; line-height: 115%; text-autospace: none;"&gt;&lt;span style="font-size: 10.0pt; line-height: 115%; font-family: 'Arial',sans-serif; mso-ansi-language: EN-ID;"&gt;[3] T. Li, Y. Wang, X. Zhang, J. Chen, and L. Sun, “Bacterial resistance to antibacterial agents: Mechanisms, control strategies, and implications for global health,” Sci. Total Environ., vol. 860, p. 160148, 2023. doi: 10.1016/j.scitotenv.2022.160148.&lt;/span&gt;&lt;/p&gt;&lt;p class="MsoNormal" style="margin-top: 0cm; margin-right: 0cm; margin-bottom: 6.0pt; margin-left: 1.0cm; text-indent: -1.0cm; line-height: 115%; text-autospace: none;"&gt;&lt;span style="font-size: 10.0pt; line-height: 115%; font-family: 'Arial',sans-serif; mso-ansi-language: EN-ID;"&gt;[4] N. A. Church and J. L. McKillip, “Antibiotic resistance crisis: challenges and imperatives,” Biologia (Bratisl)., vol. 76, no. 5, pp. 1535–1550, 2021. doi: 10.2478/s11756-021-00707-5.&lt;/span&gt;&lt;/p&gt;&lt;p class="MsoNormal" style="margin-top: 0cm; margin-right: 0cm; margin-bottom: 6.0pt; margin-left: 1.0cm; text-indent: -1.0cm; line-height: 115%; text-autospace: none;"&gt;&lt;span style="font-size: 10.0pt; line-height: 115%; font-family: 'Arial',sans-serif; mso-ansi-language: EN-ID;"&gt;[5] World Health Organization, "Global Action Plan for antimicrobial resistance,” vol. 105, no. 5, p. 70780, 2015. [Online]. Available: &lt;/span&gt;&lt;span lang="EN-US"&gt;&lt;a href="https://www.who.int/publications/i/item/9789241509763" target="_new"&gt;&lt;span style="font-size: 10.0pt; line-height: 115%; font-family: 'Arial',sans-serif; mso-ansi-language: EN-ID;" lang="EN-ID"&gt;https://www.who.int/publications/i/item/9789241509763&lt;/span&gt;&lt;/a&gt;&lt;/span&gt;&lt;span style="font-size: 10.0pt; line-height: 115%; font-family: 'Arial',sans-serif; mso-ansi-language: EN-ID;"&gt;.&lt;/span&gt;&lt;/p&gt;&lt;p class="MsoNormal" style="margin-top: 0cm; margin-right: 0cm; margin-bottom: 6.0pt; margin-left: 1.0cm; text-indent: -1.0cm; line-height: 115%; text-autospace: none;"&gt;&lt;span style="font-size: 10.0pt; line-height: 115%; font-family: 'Arial',sans-serif; mso-ansi-language: EN-ID;"&gt;[6] World Health Organization, "Antibacterial agents in clinical development: an analysis of the antibacterial clinical development," 2019. [Online]. Available: &lt;/span&gt;&lt;span lang="EN-US"&gt;&lt;a href="https://www.who.int/publications/i/item/9789240000193" target="_new"&gt;&lt;span style="font-size: 10.0pt; line-height: 115%; font-family: 'Arial',sans-serif; mso-ansi-language: EN-ID;" lang="EN-ID"&gt;https://www.who.int/publications/i/item/9789240000193&lt;/span&gt;&lt;/a&gt;&lt;/span&gt;&lt;span style="font-size: 10.0pt; line-height: 115%; font-family: 'Arial',sans-serif; mso-ansi-language: EN-ID;"&gt;.&lt;/span&gt;&lt;/p&gt;&lt;p class="MsoNormal" style="margin-top: 0cm; margin-right: 0cm; margin-bottom: 6.0pt; margin-left: 1.0cm; text-indent: -1.0cm; line-height: 115%; text-autospace: none;"&gt;&lt;span style="font-size: 10.0pt; line-height: 115%; font-family: 'Arial',sans-serif; mso-ansi-language: EN-ID;"&gt;[7] M. Rizzotto, “Metal Complexes as Antimicrobial Agents,” A Search Antibact. 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The Tell-Rif (Tell in Algeria and Tunisia; Rif in Morocco) is the orogenic system fringing to the south the West Mediterranean basins. This system comprises three major tectonic-palaeogeographic zones from north to south: (1) the internal zones (AlKaPeCa for Alboran, Kabylies, Peloritan, Calabria) originating from the former northern European margin of the Maghrebian Tethys, (2) the “Flyschs zone” regarded as the former cover of the oceanic domain and (3) the external zones, forming the former southern Maghrebian Tethys margin more or less inverted. The Tell-Rif is interpreted as the direct result of the progressive closure of the Maghrebian Tethys until the collision between AlKaPeCa and Africa and, subsequently, the propagation of the deformation within Africa. This gives a consistent explanation for the offshore Neogene geodynamics and most authors share this simple scenario. Nevertheless, the current geodynamic models do not completely integrate the Tell-Rif geology. Based on the analysis of surface and sub-surface data, we propose a reappraisal of its present-day geometry in terms of geodynamic evolution. We highlight its non-cylindrical nature resulting from both the Mesozoic inheritance and the conditions of the tectonic inversion. During the Early Jurassic, we emphasize the development of NE-SW basins preceding the establishment of an E-W transform corridor connecting the Central Atlantic Ocean with the Ligurian Tethys. The Maghrebian Tethys developed just after, as the result of the Late Jurassic-Early Cretaceous left-lateral spreading between Africa and Iberia. By the Late Cretaceous, the occurrence of several tectonic events is related to the progressive convergence convergence between the two continents. A major pre-Oligocene (pre-35 Ma) compressional event is recorded in the Tell-Rif system. The existence of HP-LT metamorphic rocks associated with fragments of mantle in the External Metamorphic Massifs of the Eastern Rif and Western Tell shows that, at that time, the western part of the North-African margin was involved in a subduction below a deep basin belonging to the Maghrebian Tethys. At the same time, the closure of the West Ligurian Tethys through east-verging subduction led to a shift of the subduction, which jumped to the other side of AlKaPeCa involving both East Ligurian and Maghrebian Tethys. Slab rollback led to the development of the Oligo-Miocene back-arc basins of the West-Mediterranean, reworking the previous West Ligurian Tethys suture. The docking of AlKaPeCa against Africa occurred during the Late Burdigalian (17 Ma). Subsequently, the slab tearing triggered westward and eastward lateral movements that are responsible for the formation of the Gibraltar and Tyrrhenian Arcs respectively. The exhumation of the External Metamorphic Massifs occurred through tectonic underplating during the westward translation of the Alboran Domain. It resulted in the formation of both foredeep and wedge-top basins younger and younger westward. The lack of these elements in the eastern part of the systems signs a different evolution dominated by frontal accretion. In the discussion, we precisely address the origin of the non-cylindrical behavior of the orogenic system and question the mechanisms explaining at large scale the phases of coupling/uncoupling between the major plates.

The article presents the genesis of the Mandyczewski family based on extensive source material; the factors of Eusebius Mandyczewski’s formation as a musician, conductor, and composer are characterized. Attention is focused on the significant influence on his professional development of the well-known church history teacher of Chernivtsi University Eusebius Popovych, music teacher Sydor Vorobkevych, and violin teacher Adalbert Hrimaly. The features of the talent of the future musician in his youth are revealed (he created 82 compositions between the ages of 14 and 17). Emphasis is placed on a significant event – receiving a scholarship at the competition of young talents in Leipzig, which was a significant financial support for his further studies at the University of Vienna. The “Viennese” period of E. Mandyczewski’s creativity, which lasted 54 years, is characterized. In Vienna, he studied German studies, philosophy, literature, art history, musical disciplines; his teachers were music critic Eduard Hanslick, musicologist Martin Gustav Notteb, composer Robert Fuchs. E. Mandyczewski’s professional growth was connected with activities at the Vienna Academy of Music, the Vienna Conservatory; he was the conductor of various choirs and orchestras, archivist and bibliographer of the Viennese “Society of Friends of Music” - one of the significant centers of European musical life.&#x0D; It was found that during many years of teaching activity, the Maestro trained a whole galaxy of composers, musicologists, teachers, most of whom became stars of the musical world of Austria, Italy, England, America... Among his students are Hans Gall, Karl Behm, Hilarion Verenko, Manolis Calomiris, George Sell, Leone Sinigaglia, Karel Prochazka (senior), Marcian Negria, Joseph Alois Krieps, Julius Patzak, Ferdinand Rebay, Rosario Scalero, Gustav Uwe Yenner, and Arthur Schnabel, Karl Garinger, Ignaz Brühl, Henry Kimball Hadlita, and others. The Austrian press deservedly called the honorary citizen of Vienna E. Mandyczewski “a living musical encyclopedia”. As a theoretician, he wrote many scientific studies on the work of W. Mozart, L. Beethoven, L. Bach, K. Czerny, A. Bruckner, Strauss, etc., compiled a complete edition of the works of J. Haydn, F. Schubert (in 42 volumes), J. Brahms (in 26 volumes). It is emphasized that E. Mandyczewski is the author of 11 Ukrainian choirs, the canon for three voices “And the day goes, and the night goes...” (to the words by T. Shevchenko), music to the lyrics by Yu. Fedkovich “Wake up, Boian!”, “Kobzar’s dawn” etc., vocal works written to the texts of Serbian, Hungarian, Ukrainian, Moldovan folk songs, author’s works written to the texts by Romanian and Moldovan poets M. Eminescu, H. Koshbuk, V. Aleksandr, O. Vlahutse, etc. Research attention is focused on the authorship of vocal works of a secular and spiritual nature, among which the most significant are: “Greek Mass” for solo, choir and orchestra, the cycle “Tuscan Songs”, church works – 12 liturgies, “Cherub” for mixed choir, “Our Father” for two children’s voices, carol “Silent night, holy night”, psalms, etc.&#x0D; On the basis of primary factual sources, the influence of E. Mandyczewski on the development of musical culture and education in Bukovyna is characterized.

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Foxtail millet (Setaria italica) is planted widely in northern China, especially in Hebei, Shanxi, Shandong, and Henan provinces. Although several diseases reduce production of this important crop species, sheath blight is considered one of the important diseases of foxtail millet in China. Sheath blight is caused by a soil-borne pathogen and is difficult to control. Epidemics are most common at the late growth stage of foxtail millet. In August 2013, an outbreak was recorded in Shijiazhuang city, Hebei, with an incidence of about 60%. Typical disease symptoms consisted of large, irregular lesions with reddish-brown margin and as the disease progressed, the plants lodge. Three representative sheath fragments (each 1 cm long) were collected from diseased plants during that outbreak. The samples were disinfected with 0.5% (v/v) sodium hypochlorite, rinsed with sterile water, placed on a water agar plate, and then incubated at 26°C in the dark for two days. After the hyphae appeared, ~3-mm-long hyphal tips from typical colonies were excised and transferred to potato dextrose agar (PDA) plates. Three isolates were obtained and all showed typical features of Rhizoctonia-like fungus. Each isolate occupied its whole plate within 5 days of incubation at 26°C in the dark, and abundant aerial mycelia were produced. The color of all colonies was first orange, turning a salmon color when the mycelia matured. Orange sclerotia appeared after 2 weeks of incubation. The nuclei were stained with DAPI (2-(4-amidinophenyl)-1H-indole-6-carboxamidine) and observed under a fluorescent microscope. The hyphal cells were multinucleate and the mycelia branched at a right angle. For molecular identification of the pathogen, mycelia of each isolate were cultured in potato dextrose broth at 26°C for a week, and genomic DNA was extracted from mycelia and used as a template for PCR amplification. The primers set of ITS1 and ITS4 was used for amplification of rDNA-ITS from these isolates and the amplified rDNA-ITS regions of all isolates (GenBank Accession Nos. KJ765700, KJ765701, and KJ765702, respectively) were 99% identical to other Waitea circinata deposited in GenBank (1,2). To further confirm the pathogenicity of the isolates, freshly collected PDA plugs were inoculated on the lower leaf blades of 8-week-old seedlings of the foxtail millet variety Yugu 1. PDA plugs without the isolate were used as a negative control. Five plants were used for each isolate and negative control. After inoculation, pots were placed together in a moist chamber at 26°C. No symptoms developed on the control plants, while obvious lesions appeared on the sheaths of tested plants at 5 days post inoculation and later the plants were lodging. The fungus was re-isolated from diseased plants and confirmed to be W. circinata based on morphological characteristics and sequence analysis as previously described, completing Koch's postulates. Further, on the basis of morphological tests, pathogenicity assays, and molecular analyses, the pathogen of foxtail millet sheath blight was identified as W. circinata (4). Although Rhizoctonia solani AG-1, AG-4 has been reported in earlier studies as the pathogen causing foxtail millet sheath blight, there has been no previous report of the disease caused by W. circinata (3). To our knowledge, this is the first report of foxtail millet sheath blight caused by W. circinata in China. With the spread of high millet plant density and fertilizer application, this disease may become a major threat to foxtail millet; therefore, W. circinata should be taken into account when designing measures for disease control in foxtail millet. References: (2) K. A. de la Cerda et al. Plant Dis. 91:791, 2007. (1) M. Fiers et al. Eur. J. Plant. Pathol. 128:353, 2010. (4) W. D. Gao. Acta Phytopathol. Sinica 17:247, 1987. (3) T. Toda et al. Plant Dis. 89:536, 2005.

ABSTRACT This study aims to analyze the valuation of Islamic banking stocks using the intrinsic value method and the margin of safety Graham number, and determine whether Islamic banking stocks are undervalued or overvalued. This research is included in the descriptive quantitative research. The data source used is secondary data obtained from www.idx.co.id and www.Indopremier.com, while the research sample selection technique uses a purposive sampling method with the criteria of companies that have been IPOs for more than five years and the number of samples found consists of three Islamic banking stocks, namely BRIS, BTPS, and PNBS shares. Based on the results of the valuation of Islamic bank stocks using the intrinsic value method and margin of safety, graham numbers are obtained if the three Islamic bank stocks experience an overvalued/expensive condition above the criteria set by Benjamin Graham, the cause is because investor euphoria is quite high regarding the news of the merger of Bank Syariah Indonesia so that it can be concluded that the three Islamic banking stocks have considerable investment risks. Therefore, investors need to wait and see until the position of the Islamic bank's stock price is close to its fair price. Keywords: Graham Number, Intrinsic Value, Margin of Safety, Market Share, Islamic Banking. ABSTRAK Penelitian ini bertujuan untuk menganalisis valuasi saham perbankan syariah dengan metode intrinsik value dan margin of safety graham number, serta menentukan apakah saham perbankan syariah dalam kondisi undervalue atau overvalue. Penelitian ini termasuk kedalam penelitian kuantitatif deskriptif. Sumber data yang digunakan adalah data sekunder yang diperoleh dari www.idx.co.id dan www.indopremier.com, sedangkan teknik pemilihan sampel penelitian menggunakan metode purposive sampling dengan kriteria perusahaan yang telah IPO lebih dari lima tahun dan diperoleh jumlah sampel yang ditemukan terdiri dari tiga saham perbankan syariah, yakni saham BRIS, BTPS, dan PNBS. Berdasarkan hasil valuasi saham bank syariah dengan menggunakan metode intrinsik value dan margin of safety graham number diperoleh jika ketiga saham bank syariah tersebut mengalami kondisi overvalue/mahal berada diatas kriteria yang ditetapkan oleh Benjamin Graham, penyebabnya dikarenakan euforia investor cukup tinggi mengenai kabar merger Bank Syariah Indonesia sehingga dapat disimpulkan ketiga saham perbankan syariah memiliki risiko investasi yang cukup besar. Maka dari itu, investor perlu wait and see sampai posisi harga saham bank syariah mendekati harga wajarnya. 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AbstractThe Nemonychidae of the Nearctic Region are revised for the first time. The family is considered to contain the most primitive living weevil species, most of them associated with Araucariaceae, Podocarpaceae and Pinaceae, and spread over four biogeographical regions. The Nearctic fauna is composed of 17 species in five genera placed in two subfamilies, all associated with Pinaceae. The subfamily Rhinorhynchinae, here reported for the first time from the Nearctic, is represented by the new genus Atopomacer and its three species, all new - A. ites (type locality: Estes Park, Colorado), A. hoplites (type locality: Cerro Potosi, Nuevo León, Mexico), and A. orites (type locality: Cerro Potosí, Nuev León, Mexico). The nearest relatives seem to be those known to be associated with Podocarpaceae in New Zealand, Chile and Argentina. The subfamily Doydirhynchinae has 14 species in four genera. All species occur in the United States, and eight are also found in Canada. The only genus shared with the Palearctic is CimberisGozis, which has, apart from the type species C. attelaboides (Fabricius) from Europe, seven species in North America. These are C. bihirsuta Hatch, C. compta (LeConte), C. decipiens sp. n. (type locality: Mariposa County, California), C. elongata (LeConte), C. pallipennis (Blatchley), C. pilosa (LeConte), and C. turbans sp. n. (type locality: Wolverton, Sequoia National Park, California). Cimberis pallipennis is reinstated from synonymy with C. pilosa, and C. parvula Hatch is considered a junior synonym of C. compta. There are three new genera, Pityomacer with three new species - P carmelites (type locality: Carmel, Monterey County, California), P. nugax (type locality: Giant Forest, Tulare County, California), and P. pix (type locality: Vernon, British Columbia); Acromacer, with A. bombifrons (LeConte) transferred from Cimberis; and Lecontellus, proposed for the Nearctic species previously in the Palearctic genus Doydirhynchus Dejean, with the species L. byturoides (LeConte), L. pinicola sp. n. (type locality: W. Woffard Hts, Kern County, California), and L. slevini (Martin).

Abstract Background: Philadelphia-negative Myeloproliferative Neoplasms (MPN) include Polycythemia Vera (PV), Essential Thrombocythemia (ET) and Myelofibrosis, both Primary (PMF) and secondary to PV or ET (PPV-MF and PET-MF). A MPN is frequently the underlying cause of splanchnic vein thrombosis (SVT). Ruxolitinib, a JAK1/2 inhibitor, efficiently reduced spleen volume and improved symptoms in patients (pts) with MF and PV in the COMFORT-I/II and RESPONSE phase III trials, and in ET pts in a phase II study. We reported (Blood 2014 124:3192) that ruxolitinib was safe in pts with MPN associated to SVT and effective in reducing spleen size at the planned primary endpoint analysis at 24 weeks (w) in a phase II clinical trial. Herein we present follow up data with cut off at 1 year after core period (a total of 72 w of treatment). Methods: Main enrolment criteria included diagnosis of PV, ET, PMF or PPV-/PET-MF associated with SVT, splenomegaly &gt;5 cm below costal margin (bcm), active anticoagulant or antiaggregant thrombosis prophylaxis, platelet count (plt) &gt;100 x109/L, neutrophils count &gt;1x109/L, normal hepatic and renal function, absence of esophageal varices &gt;grade 2. Pts who completed the 24 w of study treatment and tolerated well the drug and had evidence of clinically-significant improvement were allowed to enter an extension phase aimed at collecting and reviewing safety and efficacy data. The drug was provided free of charge by Novartis, that had no role in trial design nor in data analysis. Results: Diagnosis of MPN were: PMF 8 (38.1%), PV 5 (23.8%), ET 4 (19.1%), PPV-MF 3 (14.3%), PET-MF 1 (4.8%). Nineteen pts had spleno-porto-mesenteric thrombosis and 3 Budd-Chiari syndrome (BCS); one pt had both sites involved. Initial dose of ruxolitinib was 10 mg BID for PV, 25 mg BID for ET, 15 mg BID for MF pts with baseline (bl) platelet count of 100 to 200x109/L and 20 mg BID for platelet count &gt;200x109/L. Currently 17/21 pts are on active treatment, 14 completed w72; final data for all 17 pts will be available at meeting. One pt with MF discontinued from the study being shifted to commercial ruxolitinib at w60, one ET and one MF pt discontinued for inefficacy at w24 and one MF pt for an unrelated adverse event after w72. Efficacy: 13/21 (61.9%) pts obtained a ≥50% spleen length (sl) reduction by palpation at w24, that was maintained at w72 in 8/14 pts (57.1%). Median sl reduction at w72 was 63% (range 0-100). No significant differences in resistive or pulsatility index of splanchnic artery were noted, nor in esophageal varices status evaluated at w72. 10/11 evaluated pts with echocardiography at w72 showed a median reduction of the cardiac output of 20.1% (range 2.3-42.2) mainly due to a reduction of heart rate and of cardiac index (-21.9%, range 8.8-44.3) due to increase in body surface area. The first effect could be attributed to decrease of proinflammatory cytokines, the second to weight gain associated with ruxolitinib. Symptomatology was evaluated by MPN-SAF up to w24, showing a median total symptom score reduction from 65 to 42. Safety: regardless of drug relationship, the most common adverse events (AE) (% any grade, % grade ≥3) were thrombocythopenia (57.1%; 14.3%) and anemia (33.3%, 19%) that were the main reasons for dose adjustments. Other AE included AST or ALT increase (42.9%, 0%), diarrhea (28.6%, 0%), abdominal pain (23.8%, 0%), ascites (19%, 0%), fever (23.8%, 0%), neutropenia, (9.5%, 9.5%), upper airways infection (19%, 0%), weight gain (14.3%, 4.8%), muscle cramps (14.3%, 0%). Three serious AE occurred: one case of hepatocarcinoma in a pts with BCS, one grade 2 pneumonia and one grade 2 haematemesis not related to esophageal varices. Median ruxolitinib total daily dose at w72, after dose adjustments, was 19.1 mg for MF, 16 mg for PV and 28.3 mg for ET. Median hemoglobin reduced from 12.9 gr/dL (range 9.4-16.7) at bl to 10.7 (8.4-14.4) at w16 and recovered at w72 (12.1, range 10.8-14.7). No pts received transfusions. Median platelet count was 212 x109/L (100-389) at bl, reached to the lowest level at w4 (139, range 48-252) and improved to 160 (69-285) at w72. Median leukocyte count decreased from 7.3 x109/L (1.8-16.4) at bl to 4.08 (1.2-21.7) at w 24, and remained substantially stable through w 72 (4.96; range 2.45-17.3). Median reduction of JAK2 allele burden at w72 was 9% (range 0-38). Conclusions: At w 72 follow up, ruxolitinib continues to be safe in pts with MPN associated to SVT and maintains efficacy against splenomegaly in 57% of the pts. Disclosures De Stefano: Roche: Research Funding; GlaxoSmithKline: Speakers Bureau; Bruno Farmaceutici: Research Funding; Novartis: Research Funding, Speakers Bureau; Janssen Cilag: Research Funding; Celgene: Speakers Bureau; Shire: Speakers Bureau; Amgen: Speakers Bureau. Barbui:Novartis: Speakers Bureau. Vannucchi:Novartis: Other: Research Funding paid to institution (University of Florence), Research Funding; Shire: Speakers Bureau; Baxalta: Membership on an entity's Board of Directors or advisory committees; Novartis: Membership on an entity's Board of Directors or advisory committees, Speakers Bureau.