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Journal articles on the topic 'Margin status'

Author: Grafiati

Published: 2 June 2025

Last updated: 31 July 2025

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1

Balch, Glen C., Suhail K. Mithani, Jean F. Simpson, and Mark C. Kelley. "Accuracy of Intraoperative Gross Examination of Surgical Margin Status in Women Undergoing Partial Mastectomy for Breast Malignancy." American Surgeon 71, no. 1 (2005): 22–28. http://dx.doi.org/10.1177/000313480507100104.

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Margin status is an important prognostic factor for local recurrence after partial mastectomy for breast malignancy. Options for intraoperative evaluation of margin status include gross examination of the specimen, frozen section, and “touch preparation” cytology. This study evaluates the accuracy of gross examination without other intraoperative pathological analysis as a method of determining margin status. Records of 254 consecutive patients undergoing partial mastectomy for 255 breast malignancies (199 invasive, 56 DCIS) over 6 years were analyzed retrospectively. All women underwent en bl

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Bellizzi, A. M., M. Bloomston, S. M. Bellizzi, W. L. Marsh, and W. L. Frankel. "Assessment of prognostic factors in pancreatic ductal adenocarcinoma: Focus on the retroperitoneal margin." Journal of Clinical Oncology 27, no. 15_suppl (2009): e15670-e15670. http://dx.doi.org/10.1200/jco.2009.27.15_suppl.e15670.

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e15670 Background: Pancreatic ductal adenocarcinoma (PDA) is a leading cause of cancer death in the West, with a nearly superimposable incidence and mortality. Resection is the only chance for cure, and various features in resection specimens correlate with outcome. While most consider the uncinate margin (UM) to be the true retroperitoneal margin, it has been suggested that the posterior pancreatic surface (PPS) may also be important. At another site with a retroperitoneal margin (i.e. rectum), 1 mm margins are significant. We thus evaluated margin status in various ways, focusing on the retr

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Papavasiliou, Pavlos, Jonathan R. Piposar, Rodrigo Arrangoiz, et al. "Margin status and neoadjuvant chemoradiation in patients with borderline resectable pancreatic cancer." Journal of Clinical Oncology 30, no. 4_suppl (2012): 304. http://dx.doi.org/10.1200/jco.2012.30.4_suppl.304.

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304 Background: The objective of this study was to examine the effect of margin status and neoadjuvant therapy in determining outcomes for borderline resectable (BLR) pancreatic cancer and how neoadjuvant chemoradiation impacts margin of resection. Methods: A retrospective chart review was conducted to identify patients who underwent resection for BLR pancreatic cancer based on the AHPBA/SSO/SSAT consensus definition. Outcomes including overall survival (OS) and disease free survival (DFS) were determined based on margin status, location of positive margin (artery, vein, or pancreas), and rece

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Klimberg, V. Suzanne, Steve Harms, and Soheila Korourian. "Assessing margin status." Surgical Oncology 8, no. 2 (1999): 77–84. http://dx.doi.org/10.1016/s0960-7404(99)00031-6.

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Szewczyk, Mateusz, Jakub Pazdrowski, Piotr Pieńkowski, et al. "A Matter of Margins in Oral Cancer—How Close Is Enough?" Cancers 16, no. 8 (2024): 1488. http://dx.doi.org/10.3390/cancers16081488.

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In patients with oral cancer, the risk factors for local, regional, and distant recurrence according to margin status have not been well established. We aimed to determine the risk factors for recurrence by margin status and to identify a margin cut-off point for improved survival in patients with close margins. We retrospectively reviewed adult patients treated at our centre from 2009 to 2021 for primary oral cancer. Margins were classified as positive (<1 mm), close (1 to 4.9 mm), or clear (>5 mm). Univariate and multivariate analyses were performed. A total of 326 patients (210 men) w

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Dunst, Jürgen, and Kathrin Dellas. "Margins! Margins. Margins? How Important Is Margin Status in Breast-Preserving Therapy?" Breast Care 6, no. 5 (2011): 359–62. http://dx.doi.org/10.1159/000333145.

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Chae, Sumin, and Sun Young Min. "Association of Surgical Margin Status with Oncologic Outcome in Patients Treated with Breast-Conserving Surgery." Current Oncology 29, no. 12 (2022): 9271–83. http://dx.doi.org/10.3390/curroncol29120726.

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We aimed to compare the prognosis of patients with close resection margins after breast-conserving surgery (BCS) with that of patients with negative margins and identified predictors of residual disease. A total of 542 patients with breast cancer who underwent BCS between 2003 and 2019 were selected and divided into the close margin (114 patients) and negative margin (428 patients) groups. The median follow-up period was 72 (interquartile range, 42–113) months. Most patients received radiation therapy (RTx) and systemic therapy according to their stage and molecular subtype. The 10-year locore

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Kumar, Anupama Praveen, Diego Vicente, Praveen Kumar Raj Kumar, et al. "Abstract 3363: Clinicopathologic factors associated with surgical margins in primary invasive breast cancer." Cancer Research 82, no. 12_Supplement (2022): 3363. http://dx.doi.org/10.1158/1538-7445.am2022-3363.

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Abstract Background: For breast cancer patients undergoing lumpectomy, margin status remains an important risk factor for local recurrence. Positive margins mandate re-excision, and some patients may require multiple resections and mastectomy to obtain negative margins. In this study, association of various clinicopathologic factors with positive surgical margins for primary invasive breast cancer was assessed using both public and in-house datasets. Method: The datasets were obtained from The Cancer Genome Atlas-Breast Cancer (TCGA-BC) and Clinical Breast Care Project (CBCP). The proportion o

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Dunne, Clive, John P. Burke, Monica Morrow, and Malcolm R. Kell. "Effect of Margin Status on Local Recurrence After Breast Conservation and Radiation Therapy for Ductal Carcinoma In Situ." Journal of Clinical Oncology 27, no. 10 (2009): 1615–20. http://dx.doi.org/10.1200/jco.2008.17.5182.

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Purpose There is no consensus on what constitutes an adequate surgical margin in patients receiving breast-conserving surgery (BCS) and postoperative radiation therapy (RT) for ductal carcinoma in situ (DCIS). Inadequate margins may result in high local recurrence, and excessively large resections may lead to poor cosmetic outcome without oncologic benefit. Methods A comprehensive search for published trials that examined outcomes after adjuvant RT after BCS for DCIS was performed using MEDLINE and cross referencing available data. Reviews of each study were conducted, and data were extracted.

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Koopmansch, Caroline, Jean-Christophe Noël, Calliope Maris, Philippe Simon, Marième Sy, and Xavier Catteau. "Intraoperative Evaluation of Resection Margins in Breast-Conserving Surgery for In Situ and Invasive Breast Carcinoma." Breast Cancer: Basic and Clinical Research 15 (January 2021): 117822342199345. http://dx.doi.org/10.1177/1178223421993459.

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Background: The challenge of breast-conserving surgery (BCS) is to remove the entire tumour with free margins and avoid secondary excision that may adversely affect the cosmetic outcome. Consequently, intraoperative evaluation of surgical margins is critical. The aims of this study were multiple. First, to analyse our methodology of intraoperative examination of the resection margins and to evaluate radiological and pathological methods in the assessment of the surgical margins. Second, to evaluate the factors associated with positive margins in our patient population. M&m: The data on the

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Kell, M. R., C. Dunne, C. Canning, and M. Morrow. "The effect of margin status on local recurrence following breast conservation and radiation therapy for DCIS." Journal of Clinical Oncology 25, no. 18_suppl (2007): 597. http://dx.doi.org/10.1200/jco.2007.25.18_suppl.597.

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597 Background: There is no consensus on what constitutes an adequate surgical margin in patients receiving breast conserving surgery (BCS) and postoperative irradiation (RT) for ductal carcinoma in situ (DCIS). Inadequate margins may result in high local recurrence, and excessively large resections may lead to poor cosmetic outcome without oncological benefit. Methods: A comprehensive search for published trials which examined outcomes after adjuvant RT following BCS for DCIS was performed using medline and cross referencing available data. Reviews of each study were conducted, and data were

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Morris, Lindsay Kaye, Alaa Altahan, John Mays, et al. "Impact of margin status on survival after radical nephrectomy for renal cell carcinoma (RCC)." Journal of Clinical Oncology 35, no. 15_suppl (2017): e16084-e16084. http://dx.doi.org/10.1200/jco.2017.35.15_suppl.e16084.

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e16084 Background: Data is limited regarding outcomes in patients with RCC with positive surgical margins. We sought to evaluate the impact of margin status after radical nephrectomy (RN) on relapse free survival (RFS) and overall survival (OS). Methods: A retrospective study was conducted evaluating patients with RCC having undergone RN at Methodist University Hospital in Memphis, Tennessee, between January 2009 and December 2013. Patients were identified from the tumor registry at this institution, and IRB approval obtained. Patient and tumor characteristics and survival were analyzed by Gra

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Renshaw, Andrew A., Mercy Mena-Allauca, and Edwin W. Gould. "Reporting Margin Status in Synoptic Reports." JCO Clinical Cancer Informatics, no. 1 (November 2017): 1–8. http://dx.doi.org/10.1200/cci.16.00056.

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Purpose The format of a synoptic report can significantly affect the accuracy, speed, and preference with which a reader can retrieve information. The purpose of this study was to compare different formats for reporting margin status in synoptic reports of colonic carcinoma. Methods The performance of 17 nonpathologists (cancer registrars and medical and nonmedical personnel) at identifying specific information in various formatted synoptic reports was evaluated using four computerized quizzes that measured both accuracy and speed. Results Compared with the standard format (“Involved by invasi

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Vanni, Gianluca, Marco Pellicciaro, Nicola Di Lorenzo, et al. "Surgical De-Escalation for Re-Excision in Patients with a Margin Less Than 2 mm and a Diagnosis of DCIS." Cancers 16, no. 4 (2024): 743. http://dx.doi.org/10.3390/cancers16040743.

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The current surgical guidelines recommend an optimal margin width of 2 mm for the management of patients diagnosed with ductal carcinoma in situ (DCIS). However, there are still many controversies regarding re-excision when the optimal margin criteria are not met in the first resection. The purpose of this study is to understand the importance of surgical margin width, re-excision, and treatments to avoid additional surgery on locoregional recurrence (LRR). The study is retrospective and analyzed surgical margins, adjuvant treatments, re-excision, and LRR in patients with DCIS who underwent br

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Mosquera, Catalina, Helen M. Johnson, Anastasios T. Mitsakos, et al. "Predictive Value of Preoperative Serum CA19-9 on Margin Status." American Surgeon 85, no. 9 (2019): 965–72. http://dx.doi.org/10.1177/000313481908500937.

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Serum carbohydrate antigen (CA19-9) is known to correlate with stage, resectability, and prognosis of pancreatic cancer. The goal of pancreaticoduodenectomy is to achieve an R0 resection because worse outcomes are reported in the presence of positive margins. The purpose of this study was to evaluate the predictive utility of CA19-9 for pancreaticoduodenectomy margin status. A retrospective review of patients with pancreatic adenocarcinoma undergoing pancreaticoduodenectomy between October 2007 and November 2018 at our institution was performed. Patient demographics, preoperative CA19-9, and t

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Elshaer, Ahmed, Tamer El-Sayed, and Dowmitra Dasgupta. "The Future Perspectives of Redefining the Resection Margin Status in Different Cancers of Pancreas." Open Access Macedonian Journal of Medical Sciences 10, B (2022): 1484–91. http://dx.doi.org/10.3889/oamjms.2022.9867.

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Background: The interest towards the assessment of circumferential resection margins(CRM) in pancreatic cancers has been evolving over last years. Whilst several studies investigated the influence of R1-resections on survival, not many studies evaluated the prognostic value of each resection margin. In this study, we examined the different resection margins to better understand their prognostic implications on overall survival. Methods: This prospective study included a cohort of patients who had pancreaticoduodenectomy for cancer purposes at our institution from 2008 till 2013. Median f

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Gentile, Rachel, Adam D. Currey, Jared Forrester, Bonifride Tuyishimire, Jonathan Lin, and Amanda L. Kong. "The significance of margin status in patients with DCIS undergoing breast-conserving surgery." Journal of Clinical Oncology 32, no. 26_suppl (2014): 98. http://dx.doi.org/10.1200/jco.2014.32.26_suppl.98.

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98 Background: Recently, SSO/ASTRO published a consensus statement on margins for stage I and II invasive breast cancer treated with breast conserving surgery (BCS). We examined patients with ductal carcinoma in situ (DCIS) who underwent BCS to determine the effect of clinicopathologic and treatment factors including margin status, on locoregional recurrence (LRR), breast cancer-specific (BCSS) and overall survival (OS). Methods: From 2003-2010, we conducted a retrospective chart review of 253 consecutively diagnosed patients who underwent BCS for DCIS. Clincopathologic and treatment data were

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Keirns, Darby, Beau Hsia, Kiana Verplancke, Peter T. Silberstein, and Xinxin Wu. "Factors associated with positive margins in major salivary gland cancer: An NCDB analysis." Journal of Clinical Oncology 41, no. 16_suppl (2023): e18093-e18093. http://dx.doi.org/10.1200/jco.2023.41.16_suppl.e18093.

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e18093 Background: Major salivary gland cancer includes malignancies of the parotid, sublingual, and submandibular glands which represent a diverse spectrum of disease. Surgical resection is often the primary treatment. Positive tumor margins after resection have been associated with disease recurrence and worsened prognosis. This study investigates various factors and their influence on margin status. Methods: 41,705 patients with surgically treated major salivary gland cancer between 2004 and 2020 were identified in the National Cancer Database (NCDB). Factors including facility type, facili

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Schnebelen, Alicia M., Jerad M. Gardner, and Sara C. Shalin. "Margin Status in Shave Biopsies of Nonmelanoma Skin Cancers: Is It Worth Reporting?" Archives of Pathology & Laboratory Medicine 140, no. 7 (2016): 678–81. http://dx.doi.org/10.5858/arpa.2015-0313-oa.

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Context.—The practice of reporting margin status in biopsies is relatively unique to biopsies of the skin and highly variable among pathologists. Objective.—To address the accuracy of margin evaluation in shave biopsies of nonmelanoma skin cancers. Design.—We collected shave biopsies of squamous and basal cell carcinomas that appeared to have uninvolved margins on routine sign out. We obtained deeper levels on corresponding tissue blocks until blocks were exhausted and examined them for tumor at biopsy margins. Results.—Forty-seven consecutive cases were collected, including 20 squamous cell (

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Kotwall, Cyrus, Mark Ranson, Anquonette Stiles, and Mary Sue Hamann. "Relationship between Initial Margin Status for Invasive Breast Cancer and Residual Carcinoma after Re-Excision." American Surgeon 73, no. 4 (2007): 337–43. http://dx.doi.org/10.1177/000313480707300405.

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Little data exists addressing the relationship between initial margin status in a specimen from an excisional biopsy and the presence of residual carcinoma in a subsequent specimen from lumpectomy or mastectomy. We sought to determine the relationship between initial margin status and the presence of residual invasive cancer, and to identify any relationship to other variables. This study was a retrospective review of pathology reports of 582 early-stage invasive duct carcinomas with open excisional biopsies. The initial specimen was classified into one of six margin categories: multiply focal

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Irawati, Nina, and Sheng-po Hao. "Clinicopathological Parameters and Locoregional Recurrence in Oral Squamous Cell Carcinoma Patients." International Journal of Head and Neck Surgery 6, no. 4 (2015): 161–67. http://dx.doi.org/10.5005/jp-journals-10001-1247.

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ABSTRACT Objectives To study the clinicopathological parameters associated with recurrence of oral squamous carcinoma and analyze the survival of patients managed in ENT and Head and Neck Surgery Department between January 2008 and December 2013. Materials and methods Records of 178 cases were reviewed for clinical details, histopathological data, and follow-up status. Age, gender, addiction, subsite, T–N pathological staging, tumor thickness, margin status, grade of differentiation, lymphovascular permeation, perineural spread, and adjuvant therapy were analyzed. Results The recurrence rate w

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Skripenova, Silvia, and Lester J. Layfield. "Initial Margin Status for Invasive Ductal Carcinoma of the Breast and Subsequent Identification of Carcinoma in Reexcision Specimens." Archives of Pathology & Laboratory Medicine 134, no. 1 (2010): 109–14. http://dx.doi.org/10.5858/2008-0676-oar1.1.

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Abstract Context. Margin status of lumpectomy specimens is related to frequency of local recurrence. Optimal surgical technique requires microscopic margins free of carcinoma by at least 2 mm. Recurrence following lumpectomy is associated with residual carcinoma secondary to inadequate resection. Objective. To review our series of breast excisions to determine the frequency of residual carcinoma for positive, close, and negative margins. Design. We reviewed lumpectomies and excisional biopsies for invasive ductal carcinoma that had subsequent reexcisions. Margin status of specimens was recorde

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Park, Catherine C., Michihide Mitsumori, Asa Nixon, et al. "Outcome at 8 Years After Breast-Conserving Surgery and Radiation Therapy for Invasive Breast Cancer: Influence of Margin Status and Systemic Therapy on Local Recurrence." Journal of Clinical Oncology 18, no. 8 (2000): 1668–75. http://dx.doi.org/10.1200/jco.2000.18.8.1668.

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PURPOSE: To examine the relationship between pathologic margin status and outcome at 8 years after breast-conserving surgery and radiation therapy. PATIENTS AND METHODS: The study population comprised 533 patients with International Union Against Cancer/American Joint Committee on Cancer clinical stage I or II breast cancer who had assessable margins, who received at least 60 Gy to the primary tumor bed, and who had more than 8 years of potential follow-up. Each margin was scored (according to the presence of invasive or in situ disease that touched the inked surgical margin) as one of the fol

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Safi, Sarah Al, Tae-Kyung Yoo, Sae Byul Lee, et al. "Abstract PS01-06: The relationship between margin status of <2mm and local recurrence in DCIS patients." Cancer Research 84, no. 9_Supplement (2024): PS01–06—PS01–06. http://dx.doi.org/10.1158/1538-7445.sabcs23-ps01-06.

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Abstract Background: There has been controversial evidence regarding adequate margin in breast conserving surgery (BCS) for ductal carcinoma in situ (DCIS). However, the consensus is a surgical margin distance of 2 mm. Moreover, recent recommendations advised on ‘’clinical judgement’’ approach to re-excision in cases of margin distance &lt; 2mm. The ongoing controversy in DCIS margin compared to invasive cancer margin is due to the differences in post operative management. This is important as margin status is one of the modifiable risk factor for local regional recurrence in DCIS. In our

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Gokavarapu, Sandhya, Ravi Chander, Nagendra Parvataneni, and Sreenivasa Puthamakula. "Close Margins in Oral Cancers: Implication of Close Margin Status in Recurrence and Survival of pT1N0 and pT2N0 Oral Cancers." International Journal of Surgical Oncology 2014 (2014): 1–6. http://dx.doi.org/10.1155/2014/545372.

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Introduction.Among all prognostic factors, “margin status” is the only factor under clinician’s control. Current guidelines describe histopathologic margin of >5 mm as “clear margin” and 1–5 mm as “close margin.” Ambiguous description of positive margin in the published data resulted in comparison of microscopically “involved margin” and “close margin” together with “clear margin” in many publications. Authors attempted to compare the outcome of close and clear margins of stage I and stage II squamous cell carcinoma of oral cavity to investigate the efficacy of description of margin status.

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Cheng, Liang, Jeff Slezak, Erik J. Bergstralh, Robert P. Myers, Horst Zincke, and David G. Bostwick. "Preoperative Prediction of Surgical Margin Status in Patients With Prostate Cancer Treated by Radical Prostatectomy." Journal of Clinical Oncology 18, no. 15 (2000): 2862–68. http://dx.doi.org/10.1200/jco.2000.18.15.2862.

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PURPOSE: We sought to determine the preoperative factors associated with surgical margin status in patients who underwent radical prostatectomy for prostate cancer. PATIENTS AND METHODS: The study group consisted of 339 patients who were treated by radical retropubic prostatectomy and bilateral pelvic lymphadenectomy at the Mayo Clinic. None received preoperative adjuvant therapy. The mean age at the time of surgery was 66 years (range, 45 to 79 years). All specimens were totally embedded and whole-mounted. Positive surgical margin was defined as the presence of cancer cells at the inked margi

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Holder, Kenneth N., and I.-Tien Yeh. "Intraoperative Evaluation of Margin Status." Pathology Case Reviews 15, no. 5 (2010): 148–55. http://dx.doi.org/10.1097/pcr.0b013e3181f66188.

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Vlantis, Alexander C., Raymond K. Y. Tsang, Brian K. H. Yu, et al. "Nasopharyngectomy and Surgical Margin Status." Archives of Otolaryngology–Head & Neck Surgery 133, no. 12 (2007): 1296. http://dx.doi.org/10.1001/archotol.133.12.1296.

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Beck, Maximilian Heinz, Karoline Barbara Stephanie Weiler, Anna Trelinska-Finger, and Jens-Uwe Blohmer. "Prognostic Impact of Surgical Margin Status on Overall Survival of Patients with Early Breast Cancer: A Retrospective Analysis from the Department for Women’s Medicine at Charité – University Hospital Berlin." Geburtshilfe und Frauenheilkunde 84, no. 09 (2024): 837–44. http://dx.doi.org/10.1055/a-2374-2270.

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AbstractThe impact of surgical margins on the prognosis of early breast cancer remains uncertain, particularly in the context of modern treatment approaches. This study aimed to investigate whether involved margins after surgery for early breast cancer affect overall survival.We conducted a retrospective analysis of 3767 patients who underwent surgery for primary breast cancer or carcinoma in situ between 2006 and 2022 at Charité – University Hospital Berlin. Survival analysis based on margin status and a subsequent multivariate Cox regression analysis were conducted.With a median follow-up of

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Persky, Michael J., William G. Albergotti, Tanya J. Rath, et al. "Positive Margins by Oropharyngeal Subsite in Transoral Robotic Surgery for T1/T2 Squamous Cell Carcinoma." Otolaryngology–Head and Neck Surgery 158, no. 4 (2017): 660–66. http://dx.doi.org/10.1177/0194599817742852.

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Objective To compare positive margin rates between the 2 most common subsites of oropharyngeal transoral robotic surgery (TORS), the base of tongue (BOT) and the tonsil, as well as identify preoperative imaging characteristics that predispose toward positive margins. Study Design Case series with chart review. Setting Tertiary care referral center. Subjects and Methods We compared the final and intraoperative positive margin rate between TORS resections for tonsil and BOT oropharyngeal squamous cell carcinoma (OPSCC), as well as the effect of margins on treatment. A blinded neuroradiologist ex

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Hanna, Jonathan, Philip R. Brauer, Elliot Morse, and Saral Mehra. "Margins in Laryngeal Squamous Cell Carcinoma Treated with Transoral Laser Microsurgery: A National Database Study." Otolaryngology–Head and Neck Surgery 161, no. 6 (2019): 986–92. http://dx.doi.org/10.1177/0194599819874315.

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Objectives To determine national positive margin rates in transoral laser microsurgery, to compare patients with positive and negative margins, and to identify factors associated with positive margins. Study Design Retrospective review of the National Cancer Database. Setting Population based. Subjects/Methods Patients included those with TIS-T3 laryngeal squamous cell carcinoma (2004-2014). Univariable and multivariable logistic regression were used to identify predictors. Results A total of 1959 patients met inclusion criteria. The national positive margin rate was 22.3%. Sixty-five percent

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Pop, Maria Mihaela, Silviu Cristian, Orsolya Hanko-Bauer, Dana Valentina Ghiga, and Rares Georgescu. "OBTAINING ADEQUATE SURGICAL MARGIN STATUS IN BREAST-CONSERVATION THERAPY: INTRAOPERATIVE ULTRASOUND-GUIDED RESECTION VERSUS SPECIMEN MAMMOGRAPHY." Medicine and Pharmacy Reports 91, no. 2 (2018): 197–202. http://dx.doi.org/10.15386/cjmed-891.

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Background and aim. The purpose of breast-conserving surgery (BCS) for women with cancer is to perform an oncological radical procedure with disease-free margins at the final histological assessment and with the best aesthetic result possible. Intraoperative resected specimen ultrasound and intraoperative resected specimen mammography may reduce the rates of positive margins and reexcision among patients undergoing conserving therapy. Our objective is to compare the two methods with the histopathological results for a preset cut off and asses which parameters can influence the positive margin

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Mendis, Rajith, Gary Morgan, Muzib Abdul-Razak, et al. "Margin Status Predicts Outcome in Patients with Cutaneous Squamous Cell Carcinoma of the Scalp: The Westmead Hospital Experience." SKIN The Journal of Cutaneous Medicine 6, no. 4 (2022): 295–303. http://dx.doi.org/10.25251/skin.6.4.3.

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Background/Objectives: An involved or close resection margin in the setting of cutaneous SCC (cSCC) is associated with the risk of developing recurrence. The scalp poses unique anatomical challenges when obtaining adequate resection margins and further treatment may be required. We aimed to investigate the risk of recurrence in patients with scalp cSCCs and the role of adjuvant radiotherapy. Methods: Eligible patients with cSCC of the scalp treated with curative intent at Westmead hospital, Sydney, were identified and patient, tumor and treatment factors analyzed. Patients were categoriz

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Lambert, Aurélien, Julia Salleron, Alexandre Harle, et al. "Impact of positive resection margins on recurrence and survival following resection and adjuvant chemotherapy in pancreatic cancer: Results of the PRODIGE 24-CCTG PA-6 trial." Journal of Clinical Oncology 41, no. 16_suppl (2023): 4160. http://dx.doi.org/10.1200/jco.2023.41.16_suppl.4160.

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4160 Background: Pancreatic adenocarcinoma (PDAC) has a poor prognosis. Only 10-15% of patients present with resectable tumors upfront, and most patients develop recurrence and die prematurely. The data are incongruous when considering R1 status, direct invasion is not consistently a significant prognostic factor. It is recommended that 7 margins be identified for surgery: the bile duct, pancreatic neck, proximal and distal duodenum, superior mesenteric vein (SMV), superior mesenteric artery (SMA), and posterior pancreas. By analyzing data from the PRODIGE 24-CCTG PA-6 trial that validated the

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Nooijen, Lynn E., Jesus M. Banales, Marieke T. de Boer, et al. "Impact of Positive Lymph Nodes and Resection Margin Status on the Overall Survival of Patients with Resected Perihilar Cholangiocarcinoma: The ENSCCA Registry." Cancers 14, no. 10 (2022): 2389. http://dx.doi.org/10.3390/cancers14102389.

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Background: Lymph node metastasis and positive resection margins have been reported to be major determinants of overall survival (OS) and poor recurrence-free survival (RFS) for patients who underwent resection for perihilar cholangiocarcinoma (pCCA). However, the prognostic value of positive lymph nodes independently from resection margin status on OS has not been evaluated. Methods: From the European Cholangiocarcinoma (ENSCCA) registry, patients who underwent resection for pCCA between 1994 and 2021 were included in this retrospective cohort study. The primary outcome was OS stratified for

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Makouei, Fatemeh, Theresa Frehr, Tina Agander, et al. "Feasibility of a Novel 3D Ultrasound Imaging Technique for Intraoperative Margin Assessment during Tongue Cancer Surgery." Current Oncology 31, no. 8 (2024): 4414–31. http://dx.doi.org/10.3390/curroncol31080330.

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Squamous cell carcinoma (SCC) of the tongue is the most prevalent form of oral cavity cancer, with surgical intervention as the preferred method of treatment. Achieving negative or free resection margins of at least 5 mm is associated with improved local control and prolonged survival. Nonetheless, margins that are close (1–5 mm) or positive (less than 1 mm) are often observed in practice, especially for the deep margins. Ultrasound is a promising tool for assessing the depth of invasion, providing non-invasive, real-time imaging for accurate evaluation. We conducted a clinical trial using a n

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Weyhe, Dirk, Dennis Obonyo, Verena Nicole Uslar, Ingo Stricker, and Andrea Tannapfel. "Predictive factors for long-term survival after surgery for pancreatic ductal adenocarcinoma: Making a case for standardized reporting of the resection margin using certified cancer center data." PLOS ONE 16, no. 3 (2021): e0248633. http://dx.doi.org/10.1371/journal.pone.0248633.

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Factors for overall survival after pancreatic ductal adenocarcinoma (PDAC) seem to be nodal status, chemotherapy administration, UICC staging, and resection margin. However, there is no consensus on the definition for tumor free resection margin. Therefore, univariate OS as well as multivariate long-term survival using cancer center data was analyzed with regards to two different resection margin definitions. Ninety-five patients met inclusion criteria (pancreatic head PDAC, R0/R1, no 30 days mortality). OS was analyzed in univariate analysis with respect to R-status, CRM (circumferential rese

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Lim, Soo Yeun, Hani Jassim Alramadhan, HyeJeong Jeong, et al. "Survival Comparison of Different Operation Types for Middle Bile Duct Cancer: Bile Duct Resection versus Pancreaticoduodenectomy Considering Complications and Adjuvant Treatment Effects." Cancers 16, no. 2 (2024): 297. http://dx.doi.org/10.3390/cancers16020297.

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Background: Margin status is one of the most significant prognostic factors after curative surgery for middle bile duct (MBD) cancer. Bile duct resection (BDR) is commonly converted to pancreaticoduodenectomy (PD) to achieve R0 resection. Additionally, adjuvant treatment is actively performed after surgery to improve survival. However, the wider the range of surgery, the higher the chance of complications; this, in turn, makes adjuvant treatment impossible. Nevertheless, no definitive surgical strategy considers the possible complication rates and subsequent adjuvant treatment. We aimed to inv

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Forrester, Jared, Adam D. Currey, Bonifride Tuyishimire, Jonathan Lin, and Amanda L. Kong. "The effect of margin status and molecular subtype on women with invasive breast cancer treated with breast-conservation therapy." Journal of Clinical Oncology 32, no. 26_suppl (2014): 83. http://dx.doi.org/10.1200/jco.2014.32.26_suppl.83.

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83 Background: A consensus statement was recently published by SSO/ASTRO on margins for stage I and II invasive breast cancer treated with breast conserving surgery (BCS). We examined patients with invasive breast cancer who underwent BCS to determine if margin status and molecular subtype influence outcomes. Methods: We the reviewed charts of 754 Stage I-III breast cancer patients treated with BCS from 2003-2010. Margin status was defined as negative ≥ 2mm, close < 2mm and positive as tumor on ink. Conventional receptor analyses were used as markers for molecular subtype classification (lu

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Tyler, Lisa N., Nancy Andrews, Rudolph S. Parrish, Linda J. Hazlett, and Soheila Korourian. "Significance of Margin and Extent of Dysplasia in Loop Electrosurgery Excision Procedure Biopsies Performed for High-Grade Squamous Intraepithelial Lesion in Predicting Persistent Disease." Archives of Pathology & Laboratory Medicine 131, no. 4 (2007): 622–24. http://dx.doi.org/10.5858/2007-131-622-somaeo.

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Abstract Context.—High-grade squamous intraepithelial lesions (cervical intraepithelial neoplasia 2 and 3) are commonly treated with loop electrosurgery excision procedure (LEEP) biopsies. Objective.—To highlight the significance of positive margins and extent of positive margins of the cervical LEEP biopsies in predicting the persistence of high-grade squamous intraepithelial lesion and to provide suggestions for reporting margins in cervical LEEP biopsies. Design.—The pathology files at the University of Arkansas for Medical Sciences were searched for cervical intraepithelial neoplasia 2 and

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Emmadi, Rajyasree, and Elizabeth L. Wiley. "Evaluation of Resection Margins in Breast Conservation Therapy: The Pathology Perspective—Past, Present, and Future." International Journal of Surgical Oncology 2012 (2012): 1–9. http://dx.doi.org/10.1155/2012/180259.

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Tumor surgical resection margin status is important for any malignant lesion. When this occurs in conjunction with efforts to preserve or conserve the afflicted organ, these margins become extremely important. With the demonstration of no difference in overall survival between mastectomy versus lumpectomy and radiation for breast carcinoma, there is a definite trend toward smaller resections combined with radiation, constituting “breast-conserving therapy.” Tumor-free margins are therefore key to the success of this treatment protocol. We discuss the various aspects of margin status in this se

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Holm, Maia Blomhoff, and Caroline Sophie Verbeke. "Prognostic Impact of Resection Margin Status on Distal Pancreatectomy for Ductal Adenocarcinoma." Current Oncology 29, no. 9 (2022): 6551–63. http://dx.doi.org/10.3390/curroncol29090515.

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Pancreatic cancer is associated with a poor prognosis. While surgical resection is the only treatment option with curative intent, most patients die of locoregional and/or distant recurrence. The prognostic impact of the resection margin status has received much attention. However, the evidence is almost exclusively related to pancreatoduodenectomies, while corresponding data for distal pancreatectomy specimens are limited. The key data, such as the rate of microscopic margin involvement (“R1”), the site of margin involvement, and the impact of R1 on patient outcome, are divergent between stud

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Tadros, Audree, Benjamin D. Smith, Yu Shen, et al. "Contemporary breast conservation patient outcomes for ductal carcinoma in situ and margins < 2 mm." Journal of Clinical Oncology 35, no. 15_suppl (2017): 559. http://dx.doi.org/10.1200/jco.2017.35.15_suppl.559.

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559 Background: Recent national consensus guidelines regarding optimal margin width for the management of DCIS have been published; however, controversy remains for managing margins <2mm. The relationship between margin width and locoregional recurrence (LRR) was determined in a contemporary cohort of patients. Methods: 1504 patients with DCIS undergoing definitive breast conserving surgery from 1996 to 2010 were analyzed for clinical and pathologic characteristics from a prospectively managed comprehensive academic cancer center database. Cox proportional hazard models were used to examine

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Alramadhan, Hani Jassim, Soo-Yeun Lim, Hye-Jeong Jeong, et al. "Different Oncologic Outcomes According to Margin Status (High-Grade Dysplasia vs. Carcinoma) in Patients Who Underwent Hilar Resection for Mid-Bile Duct Cancer." Cancers 15, no. 21 (2023): 5166. http://dx.doi.org/10.3390/cancers15215166.

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Margin positivity after hilar resection (HR) for bile duct cancer is commonly observed due to its longitudinal spread along the subepithelial plane; nevertheless, we cannot draw conclusions regarding the prognostic effects of margins with high-grade dysplasia (HGD) or carcinoma. We aimed to investigate the oncologic effect according to the margin status after HR, particularly between the R1 HGD and the R1 carcinoma. From 2008 to 2017, 149 patients diagnosed with mid-bile duct cancer in Samsung Medical Center, South Korea, were divided according to margin status after HR and retrospectively ana

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Brown, K. M., J. Flaherty, V. Ciocca, H. Ehya, W. Scott, and M. Goldberg. "Touch prep (TP) cytology as a tool for determining pulmonary parenchymal resection margin status." Journal of Clinical Oncology 25, no. 18_suppl (2007): 18095. http://dx.doi.org/10.1200/jco.2007.25.18_suppl.18095.

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18095 Background: Accurate determination of parenchymal resection margins is critical in excision of primary and metastatic lung cancers. Complete microscopic examination of the entire margin is difficult and may not give timely results. Staple-line excision may compromise the accuracy of histologic margin exam (HME). TP offers a novel method to obtain pulmonary parenchymal margin status intraoperatively. Methods: Patients undergoing wedge resection for a known malignant lung lesion were studied prospectively. At the time of resection, the specimen stapled margin underwent TP on 3 glass slides

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Sambri, Andrea, Emilia Caldari, Michele Fiore, et al. "Margin Assessment in Soft Tissue Sarcomas: Review of the Literature." Cancers 13, no. 7 (2021): 1687. http://dx.doi.org/10.3390/cancers13071687.

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Adequacy of margins must take into consideration both the resection margin width (quantity) and anatomic barrier (quality). There are several classification schemes for reporting surgical resection margin status for soft tissue sarcomas (STS). Most of the studies regarding treatment outcomes in STS included all histologic grades and histological subtypes, which include infiltrative and non-infiltrative subtypes and are very heterogeneous in terms of both histologic characteristics and treatment modalities (adjuvant treatments or not). This lack of consistency makes it difficult to compare resu

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Wang, Yu-Chih, Yi-Ju Chen, Yu-Hsuan Shih, and Feng-Hsu Wu. "Assessment of the Relationship Between Positive Radial Margin and Prognosis in Patients with Gastric Adenocarcinoma." Cancers 17, no. 9 (2025): 1463. https://doi.org/10.3390/cancers17091463.

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Background/Objectives: Gastrectomy is among the most effective treatments for gastric adenocarcinoma. Margin status can be categorized into three types: proximal, distal, and radial margins. While the relationship between proximal and distal margin involvement in specimens and prognosis has been extensively studied, the impact of a radial margin has not been thoroughly investigated. This study was conducted to determine whether a positive radial margin could affect the prognosis of patients with gastric adenocarcinoma undergoing gastrectomy. Methods: This is a retrospective cohort study of pat

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Jang, Jeon Yeob, Nayeon Choi, and Han-Sin Jeong. "Surgical Extent for Oral Cancer: Emphasis on a Cut-Off Value for the Resection Margin Status: A Narrative Literature Review." Cancers 14, no. 22 (2022): 5702. http://dx.doi.org/10.3390/cancers14225702.

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The optimal cut-off point of the resection margin was recently debated in oral cancer. To evaluate the current evidence of the dynamic criteria of the resection margin, a review of the available literature was performed. Studies were sourced from PubMed and EMBASE by searching for the keywords “mouth neoplasm”, “oral cancer”, “oral cavity cancer”, “oral squamous cell carcinoma”, “tongue cancer”, “margins of excision”, “surgical margin” and “resection margin”. We found approximately 998 articles on PubMed and 2227 articles on EMBASE. A total of 3225 articles was identified, and 2763 of those we

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Qu, Feilin, Cheng-Jia Shen, Wen-Tao Yang, Jun-Jie Li, Guangyu Liu, and Zhi-Ming Shao. "Abstract PO1-22-09: Current margin assessment practice for breast-conserving surgery in China: a single institution audit." Cancer Research 84, no. 9_Supplement (2024): PO1–22–09—PO1–22–09. http://dx.doi.org/10.1158/1538-7445.sabcs23-po1-22-09.

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Abstract Background The appropriate negative margin width following breast-conserving surgery (BCS) for both ductal carcinoma in situ (DCIS) and invasive carcinoma (IC) has witnessed a shift towards de-escalation in international guidelines. However, there are limited nationwide data regarding margin assessment practice for BCS in China. This study aims to clarify the current real-world status of margin assessment from a single institution audit and secondarily to update the evidence on the association between margin width and local recurrence. Methods Eligible cases were derived from an exten

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Mathur, Abhishek, Sharona B. Ross, Kenneth Luberice, et al. "Margin Status Impacts Survival after Pancreaticoduodenectomy but Negative Margins Should Not be Pursued." American Surgeon 80, no. 4 (2014): 353–60. http://dx.doi.org/10.1177/000313481408000416.

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Negative margins are the goal with pancreaticoduodenectomy for pancreatic adenocarcinoma. Thereby, margins are assessed intraoperatively with frozen section analysis and negative margins are pursued. This study was undertaken to determine the impact of margin status with pancreaticoduodenectomy for pancreatic adenocarcinoma and the value of extending resections to achieve negative margins. The intraoperative frozen section analysis and final margins for 448 patients undergoing pancreaticoduodenectomy for pancreatic adenocarcinoma were assessed and their impact on survival was determined. Media

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