Relevant bibliographies by topics / Marine derived drugs

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  1. Journal articles
  2. Dissertations / Theses
  3. Book chapters

Academic literature on the topic 'Marine derived drugs'

Author: Grafiati
Published: 20 February 2023

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Journal articles on the topic "Marine derived drugs"

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Shikov, Alexander N., Elena V. Flisyuk, Ekaterina D. Obluchinskaya, and Olga N. Pozharitskaya. "Pharmacokinetics of Marine-Derived Drugs." Marine Drugs 18, no. 11 (2020): 557. http://dx.doi.org/10.3390/md18110557.

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Marine organisms represent an excellent source of innovative compounds that have the potential for the development of new drugs. The pharmacokinetics of marine drugs has attracted increasing interest in recent decades due to its effective and potential contribution to the selection of rational dosage recommendations and the optimal use of the therapeutic arsenal. In general, pharmacokinetics studies how drugs change after administration via the processes of absorption, distribution, metabolism, and excretion (ADME). This review provides a summary of the pharmacokinetics studies of marine-derived active compounds, with a particular focus on their ADME. The pharmacokinetics of compounds derived from algae, crustaceans, sea cucumber, fungus, sea urchins, sponges, mollusks, tunicate, and bryozoan is discussed, and the pharmacokinetics data in human experiments are analyzed. In-depth characterization using pharmacokinetics is useful for obtaining information for understanding the molecular basis of pharmacological activity, for correct doses and treatment schemes selection, and for more effective drug application. Thus, an increase in pharmacokinetic research on marine-derived compounds is expected in the near future.
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De, Oindrila, and Biswa P. Chatterji. "Marine Derived Anticancer Drugs Targeting Microtubule." Recent Patents on Anti-Cancer Drug Discovery 12, no. 2 (2017): 102–27. http://dx.doi.org/10.2174/1574892812666170109141003.

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Cao, Qi, Jiarui Zhao, Maochen Xing, et al. "Current Research Landscape of Marine-Derived Anti-Atherosclerotic Substances." Marine Drugs 18, no. 9 (2020): 440. http://dx.doi.org/10.3390/md18090440.

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Atherosclerosis is a chronic disease characterized by lipid accumulation and chronic inflammation of the arterial wall, which is the pathological basis for coronary heart disease, cerebrovascular disease and thromboembolic disease. Currently, there is a lack of low-cost therapeutic agents that effectively slow the progression of atherosclerosis. Therefore, the development of new drugs is urgently needed. The research and development of marine-derived drugs have gained increasing interest from researchers across the world. Many marine organisms provide a rich material basis for the development of atherosclerotic drugs. This review focuses on the latest technological advances in the structures and mechanisms of action of marine-derived anti-atherosclerotic substances and the challenges of the application of these substances including marine polysaccharides, proteins and peptides, polyunsaturated fatty acids and small molecule compounds. Here, we describe the theoretical basis of marine biological resources in the treatment of atherosclerosis.
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Jeong, Geum-Jae, Sohail Khan, Nazia Tabassum, Fazlurrahman Khan, and Young-Mog Kim. "Marine-Bioinspired Nanoparticles as Potential Drugs for Multiple Biological Roles." Marine Drugs 20, no. 8 (2022): 527. http://dx.doi.org/10.3390/md20080527.

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The increased interest in nanomedicine and its applicability for a wide range of biological functions demands the search for raw materials to create nanomaterials. Recent trends have focused on the use of green chemistry to synthesize metal and metal-oxide nanoparticles. Bioactive chemicals have been found in a variety of marine organisms, including invertebrates, marine mammals, fish, algae, plankton, fungi, and bacteria. These marine-derived active chemicals have been widely used for various biological properties. Marine-derived materials, either whole extracts or pure components, are employed in the synthesis of nanoparticles due to their ease of availability, low cost of production, biocompatibility, and low cytotoxicity toward eukaryotic cells. These marine-derived nanomaterials have been employed to treat infectious diseases caused by bacteria, fungi, and viruses as well as treat non-infectious diseases, such as tumors, cancer, inflammatory responses, and diabetes, and support wound healing. Furthermore, several polymeric materials derived from the marine, such as chitosan and alginate, are exploited as nanocarriers in drug delivery. Moreover, a variety of pure bioactive compounds have been loaded onto polymeric nanocarriers and employed to treat infectious and non-infectious diseases. The current review is focused on a thorough overview of nanoparticle synthesis and its biological applications made from their entire extracts or pure chemicals derived from marine sources.
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Pereira, Renato B., Nikolai M. Evdokimov, Florence Lefranc, et al. "Marine-Derived Anticancer Agents: Clinical Benefits, Innovative Mechanisms, and New Targets." Marine Drugs 17, no. 6 (2019): 329. http://dx.doi.org/10.3390/md17060329.

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The role of the marine environment in the development of anticancer drugs has been widely reviewed, particularly in recent years. However, the innovation in terms of clinical benefits has not been duly emphasized, although there are important breakthroughs associated with the use of marine-derived anticancer agents that have altered the current paradigm in chemotherapy. In addition, the discovery and development of marine drugs has been extremely rewarding with significant scientific gains, such as the discovery of new anticancer mechanisms of action as well as novel molecular targets. Approximately 50 years since the approval of cytarabine, the marine-derived anticancer pharmaceutical pipeline includes four approved drugs and eighteen agents in clinical trials, six of which are in late development. Thus, the dynamic pharmaceutical pipeline consisting of approved and developmental marine-derived anticancer agents offers new hopes and new tools in the treatment of patients afflicted with previously intractable types of cancer.
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Li, Tingting, Ting Ding, and Jianrong Li. "Medicinal Purposes: Bioactive Metabolites from Marine-derived Organisms." Mini-Reviews in Medicinal Chemistry 19, no. 2 (2018): 138–64. http://dx.doi.org/10.2174/1389557517666170927113143.

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The environment of marine occupies about 95% biosphere of the world and it can be a critical source of bioactive compounds for humans to be explored. Special environment such as high salt, high pressure, low temperature, low nutrition and no light, etc. has made the production of bioactive substances different from terrestrial organisms. Natural ingredients secreted by marine-derived bacteria, fungi, actinomycetes, Cyanobacteria and other organisms have been separated as active pharmacophore. A number of evidences have demonstrated that bioactive ingredients isolated from marine organisms can be other means to discover novel medicines, since enormous natural compounds from marine environment were specified to be anticancer, antibacterial, antifungal, antitumor, cytotoxic, cytostatic, anti-inflammatory, antiviral agents, etc. Although considerable progress is being made within the field of chemical synthesis and engineering biosynthesis of bioactive compounds, marine environment still remains the richest and the most diverse sources for new drugs. This paper reviewed the natural compounds discovered recently from metabolites of marine organisms, which possess distinct chemical structures that may form the basis for the synthesis of new drugs to combat resistant pathogens of human life. With developing sciences and technologies, marine-derived bioactive compounds are still being found, showing the hope of solving the problems of human survival and sustainable development of resources and environment.
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Kabir, Md Tanvir, Md Sahab Uddin, Philippe Jeandet, et al. "Anti-Alzheimer’s Molecules Derived from Marine Life: Understanding Molecular Mechanisms and Therapeutic Potential." Marine Drugs 19, no. 5 (2021): 251. http://dx.doi.org/10.3390/md19050251.

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Alzheimer’s disease (AD) is a devastating neurodegenerative disease and the most common cause of dementia. It has been confirmed that the pathological processes that intervene in AD development are linked with oxidative damage to neurons, neuroinflammation, tau phosphorylation, amyloid beta (Aβ) aggregation, glutamate excitotoxicity, and cholinergic deficit. Still, there is no available therapy that can cure AD. Available therapies only manage some of the AD symptoms at the early stages of AD. Various studies have revealed that bioactive compounds derived from marine organisms and plants can exert neuroprotective activities with fewer adverse events, as compared with synthetic drugs. Furthermore, marine organisms have been identified as a source of novel compounds with therapeutic potential. Thus, there is a growing interest regarding bioactive compounds derived from marine sources that have anti-AD potentials. Various marine drugs including bryostatin-1, homotaurine, anabaseine and its derivative, rifampicins, anhydroexfoliamycin, undecylprodigioisin, gracilins, 13-desmethyl spirolide-C, and dictyostatin displayed excellent bioavailability and efficacy against AD. Most of these marine drugs were found to be well-tolerated in AD patients, along with no significant drug-associated adverse events. In this review, we focus on the drugs derived from marine life that can be useful in AD treatment and also summarize the therapeutic agents that are currently used to treat AD.
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Zuo, Weimin, and Hang Fai Kwok. "Development of Marine-Derived Compounds for Cancer Therapy." Marine Drugs 19, no. 6 (2021): 342. http://dx.doi.org/10.3390/md19060342.

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Cancer has always been a threat to human health with its high morbidity and mortality rates. Traditional therapy, including surgery, chemotherapy and radiotherapy, plays a key role in cancer treatment. However, it is not able to prevent tumor recurrence, drug resistance and treatment side effects, which makes it a very attractive challenge to search for new effective and specific anticancer drugs. Nature is a valuable source of multiple pharmaceuticals, and most of the anticancer drugs are natural products or derived from them. Marine-derived compounds, such as nucleotides, proteins, peptides and amides, have also shed light on cancer therapy, and they are receiving a fast-growing interest due to their bioactive properties. Their mechanisms contain anti-angiogenic, anti-proliferative and anti-metastasis activities; cell cycle arrest; and induction of apoptosis. This review provides an overview on the development of marine-derived compounds with anticancer properties, both their applications and mechanisms, and discovered technologies.
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Bracegirdle, Joe, and Robert A. Keyzers. "Marine-derived Polyaromatic Butenolides - Isolation, Synthesis and Biological Evaluations." Current Pharmaceutical Design 26, no. 35 (2020): 4351–61. http://dx.doi.org/10.2174/1381612826666200518110617.

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Marine invertebrates, especially tunicates, are a lucrative resource for the discovery of new lead compounds for the development of clinically utilized drugs. This review describes the isolation, synthesis and biological activities of several classes of marine-derived butenolide natural products, namely rubrolides and related cadiolides and prunolides. All relevant studies pertaining to these compounds up to the end of 2019 are included.
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Durães, Fernando, Nikoletta Szemerédi, Decha Kumla, et al. "Metabolites from Marine-Derived Fungi as Potential Antimicrobial Adjuvants." Marine Drugs 19, no. 9 (2021): 475. http://dx.doi.org/10.3390/md19090475.

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Marine-derived fungi constitute an interesting source of bioactive compounds, several of which exhibit antibacterial activity. These acquire special importance, considering that antimicrobial resistance is becoming more widespread. The overexpression of efflux pumps, capable of expelling antimicrobials out of bacterial cells, is one of the most worrisome mechanisms. There has been an ongoing effort to find not only new antimicrobials, but also compounds that can block resistance mechanisms which can be used in combination with approved antimicrobial drugs. In this work, a library of nineteen marine natural products, isolated from marine-derived fungi of the genera Neosartorya and Aspergillus, was evaluated for their potential as bacterial efflux pump inhibitors as well as the antimicrobial-related mechanisms, such as inhibition of biofilm formation and quorum-sensing. Docking studies were performed to predict their efflux pump action. These compounds were also tested for their cytotoxicity in mouse fibroblast cell line NIH/3T3. The results obtained suggest that the marine-derived fungal metabolites are a promising source of compounds with potential to revert antimicrobial resistance and serve as an inspiration for the synthesis of new antimicrobial drugs.
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Dissertations / Theses on the topic "Marine derived drugs"

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Noor, Humaira. "Immunological Effects of Haliotis Rubra Hemolymph and Hemolymph Components." Thesis, The University of Sydney, 2017. http://hdl.handle.net/2123/17063.

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Marine derived drugs are emerging with promises to positively intervene in a range of diseases including viral, bacterial, fungal, and to even some forms of cancers. Hemolymph of several molluscs are of particular interest for their immunomodulatory properties that enhance their anti-microbial and anti-cancerous mechanisms. Our research aims to uncover the immunological effects of Haliotis rubra hemolymph, purified hemocyanin and hemolymph permeate. Their immunomodulatory properties can be key to treating Herpes Simplex Virus -1, HSV-1, infected patients and prostate cancer patients. In this study, we cultured HaCat cells and Human oral primary and prostate cancer cell line (PC-3) to observe immunomodulatory effects of the extracts on such form of cancer. Treatment with variable concentrations of abalone sera, purified hemocyanin and the sera/hemolymph were carried out. Results show a 50% inhibition in Interleukin-6 (IL-6) expression, 21% inhibition in Interleukin-8 (IL-8) . There is an observed inhibition of IL-6 expression in permeate, AH and sera treated PC-3. Additionally, the effects also extend to IL-8. The most significant results were obtained for primary oral keratinocytes treatment with the abalone sera yielding a sharp 35 fold increase in IL-8 concentration and 23 fold increase in IL-6 concentration as compared to the untreated control. To summarize: hemolymph, purified hemocyanin and hemolymph permeate targets IL-6 and IL-8 , that will potentially help HSV-1 infected and prostrate cancer patients. Whole hemolymph permeate induces highest degree of cytokine modulation in all cell types. The permeate is found to predominantly consist of hemocyanin fragments of various sizes . Therefore, broken hemocyanin fragments, rather than whole hemocyanin molecule, has greater immunomodulatory properties. HaCat cells do not fit as a model for IL-6 and IL-8 modulation studies, although targeted modulation of these cytokines are also exhibited here on hemolymph treatments.
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Hayton, Joshua Blake. "Northern New South Wales Marine Invertebrate-Derived Natural Products; A Source of Bioactive S. aureus Drug-like Molecules." Thesis, Griffith University, 2017. http://hdl.handle.net/10072/365380.

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This thesis describes the development of a rapid antistaphylococcal bioassay and chemical investigation of antistaphylococcal extracts derived from marine invertebrates collected from northern New South Wales. This thesis is divided into three sections. Chapter 2 describes the development of a novel HTS antistaphylococcal bioassay and the subsequent screening of a marine invertebrate extract collection using the developed assay. Chapters 3-7 report on the isolation and structure elucidation of natural products from antistaphylococcal extracts derived from three sponges and two bryozoans. Finally, in chapter 8, the isolated natural products were investigated to determine if they were active against Staphylococcus aureus. The MIC80 of active compounds were reported as was the bacteriostatic or bactericidal mode of action of these bioactive compounds.<br>Thesis (PhD Doctorate)<br>Doctor of Philosophy (PhD)<br>Griffith School of Environment<br>Science, Environment, Engineering and Technology<br>Full Text
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Book chapters on the topic "Marine derived drugs"

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Saeidnia, Soodabeh. "Marine-Derived Anticancer Compounds." In New Approaches to Natural Anticancer Drugs. Springer International Publishing, 2014. http://dx.doi.org/10.1007/978-3-319-14027-8_3.

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Quesada, Ana R., Beatriz Martínez-Poveda, Salvador Rodríguez-Nieto, and Miguel Ángel Medina. "Marine Sponge Derived Antiangiogenic Compounds." In Handbook of Anticancer Drugs from Marine Origin. Springer International Publishing, 2014. http://dx.doi.org/10.1007/978-3-319-07145-9_3.

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Sivakumar, Kannan, Panchanathan Manivasagan, and Se-Kwon Kim. "Marine Sponge Derived Actinomycetes and Their Anticancer Compounds." In Handbook of Anticancer Drugs from Marine Origin. Springer International Publishing, 2014. http://dx.doi.org/10.1007/978-3-319-07145-9_34.

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Kigoshi, Hideo, and Masaki Kita. "Antitumor Effects of Sea Hare-Derived Compounds in Cancer." In Handbook of Anticancer Drugs from Marine Origin. Springer International Publishing, 2014. http://dx.doi.org/10.1007/978-3-319-07145-9_33.

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Swami, Umang, Umang Shah, and Sanjay Goel. "Marine Sponge Derived Eribulin in Preclinical and Clinical Studies for Cancer." In Handbook of Anticancer Drugs from Marine Origin. Springer International Publishing, 2014. http://dx.doi.org/10.1007/978-3-319-07145-9_4.

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Pangestuti, Ratih, and Se-Kwon Kim. "Seaweeds-Derived Bioactive Materials for the Prevention and Treatment of Female’s Cancer." In Handbook of Anticancer Drugs from Marine Origin. Springer International Publishing, 2014. http://dx.doi.org/10.1007/978-3-319-07145-9_8.

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Hassan, Syed Shams Ul, Hui-Zi Jin, Abdur Rauf, Saud Bawazeer, and Hafiz Ansar Rasul Suleria. "Marine Fungi-Derived Secondary Metabolites: Potential as Future Drugs for Health Care." In Health Benefits of Secondary Phytocompounds from Plant and Marine Sources. Apple Academic Press, 2020. http://dx.doi.org/10.1201/9781003019602-10.

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Alamgir, A. N. M. "Bioactive Compounds and Pharmaceutical Excipients Derived from Animals, Marine Organisms, Microorganisms, Minerals, Synthesized Compounds, and Pharmaceutical Drugs." In Progress in Drug Research. Springer International Publishing, 2018. http://dx.doi.org/10.1007/978-3-319-92387-1_4.

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Sharifian, Sana, and Ahmad Homaei. "Marine-Derived Polysaccharides: Prospects for Future Pharmaceuticals and Drug Delivery Systems." In Marine Biomaterials. Springer Singapore, 2022. http://dx.doi.org/10.1007/978-981-16-4787-1_12.

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Roy, Harekrishna, Asha Gummadi, and Sisir Nandi. "Potential Biomedical Applications of Marine Sponge-Derived Chitosan: Current Breakthroughs in Drug Delivery for Wound Care." In Wound Healing Research. Springer Singapore, 2021. http://dx.doi.org/10.1007/978-981-16-2677-7_16.

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Journal articles
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