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Dissertations / Theses on the topic 'Marine sponge'

Author: Grafiati
Published: 4 June 2021
Last updated: 25 July 2025

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1

Kalusa, Andrew. "Synthesis of marine alkaloids." Thesis, University of Oxford, 2003. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.275274.

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2

Northcote, Peter T. "Novel terpenoid metabolites from the marine sponge xestopongia vanilla." Thesis, University of British Columbia, 1989. http://hdl.handle.net/2429/29253.

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A chemical study of the marine petrosid sponge Xestospongia vanilla has led to the isolation of nine new isoprene derived secondary metabolites. Their proposed structures were elucidated by a combination of spectroscopic analysis and chemical degradation and interconversions. Xestodiol (94), a C₁₈ apocarotenoid, appears to be a degradation product of the abundant marine carotenoid fucoxanthin (103). The xestovanins (98-102) are triterpene glycosides; their isolation represents the second reported occurrence of this type of compound from sponges. Their triterpene carbon skeletons are unique, a
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3

Mulheron, Rebecca. "Microbial Community Assembly found with Sponge Orange Band Disease in Xestospongia muta (Giant Barrel Sponge)." NSUWorks, 2014. http://nsuworks.nova.edu/occ_stuetd/18.

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The giant barrel sponge, Xestospongia muta is an iconic and essential species of the coral reefs in South Florida. The sponge has primary roles providing ecosystem services and creating unique habitats for diverse microbial communities. On April 27, 2012 an outbreak of Sponge Orange Band Disease (SOB) was detected off the coast of South Florida. The disease begins with sponge bleaching, followed by mesohyl or “mesohyl” necrosis and often total mesohyl disintegration. Sampling from two diseased populations at Boynton Beach and Fort Lauderdale, FL took place on May 11th and May 29th, 2012. Each
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4

Kottakota, Suresh Kumar. "The synthesis of novel biologically active marine sponge secondary metabolites." Thesis, University of Sunderland, 2014. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.592881.

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Bromotyrosine-derived secondary metabolites from marine sponges of the order Verongida provide unique diversity in chemical structure and a wide range of biological activities. With a decline in the number of novel antibiotic scaffolds which are emerging and the on-going search for more effective antibacterial and anticancer drugs, these brominated metabolites are attractive candidates for further total synthesis and biological evaluation. An Efficient total synthesis of bromotyrosine alkaloids purpurealdin E (92), aplyzanzine A (122), suberedamine A (123) and B (124), iso-Anomoian A (121a) an
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5

Li, Hang, and n/a. "Chemical investigations of Natural Products from Australian Marine Sponge-Derived Fungi." Griffith University. Eskitis Institute for Cell and Molecular Therapies, 2007. http://www4.gu.edu.au:8080/adt-root/public/adt-QGU20081103.091038.

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This thesis described the chemical investigations of natural products from Australian marine sponge-derived fungi. Sponge samples were collected from the Great Barrier Reef, Queensland, Australia, by Queensland Museum. The thesis is divided into eight chapters and can be devided into two major parts. The first three chapters comprised the first part of the thesis: Chapter 1 outlined the research background, literature review of marine fungal secondary metabolites; Chapter 2 introduced fungal culture and storage background knowledge, and the list of isolated marine fungal strains. Chapter 3 int
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6

Rainbow, Simon C. "Towards onnamide F : a nematocide from the marine sponge Trachycladus laevispirulifer." Thesis, University of Southampton, 2008. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.494754.

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Onnamide F is a recently isolated natural product from the southern Australian marine sponge, Trachycladus laevispirulifer, that has shown significant antifungal and nematocidal activity. Onnamide F contains a tetrahydropyran substructure, known as pederic acid, and an amide bond linkage to a second tetrahydropyran. To date no total synthesis of onnamide F has been reported. A range of tetrahydropyrans with structural similarities to pederic acid were synthesised using a new Lewis acid mediated cyclisation reaction. Additionally, a diastereoselective route to tetrahydropyrans containing the ex
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7

Li, Hang. "Chemical investigations of Natural Products from Australian Marine Sponge-Derived Fungi." Thesis, Griffith University, 2007. http://hdl.handle.net/10072/367548.

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This thesis described the chemical investigations of natural products from Australian marine sponge-derived fungi. Sponge samples were collected from the Great Barrier Reef, Queensland, Australia, by Queensland Museum. The thesis is divided into eight chapters and can be devided into two major parts. The first three chapters comprised the first part of the thesis: Chapter 1 outlined the research background, literature review of marine fungal secondary metabolites; Chapter 2 introduced fungal culture and storage background knowledge, and the list of isolated marine fungal strains. Chapter 3 int
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8

Plowright, Alleyn T. "Synthetic studies towards the marine natural product phorboxazole A." Thesis, University of Nottingham, 2000. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.311837.

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9

Burkhart, Tandace L. "The Search for Novel Sponge genes: Comparative Analysis of Gene Expression in Multiple Sponges." NSUWorks, 2012. http://nsuworks.nova.edu/occ_stuetd/194.

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This project focuses on the use of sponge genetic transcripts in the form of expressed sequence tags (ESTs) readily available in Genbank to search for novel genes using bioinformatics analysis tools. Marine sponge species are known to house a diversity of marine microbes and are known as the ‘living fossils’ of the animal kingdom because of the large number of ancient genes they house. Genomic mining can be a useful tool in discovering these orthologous genes. This study utilized the techniques of genomic mining of 11 previously described sponge species transcripts. The results of this study p
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10

Smith, J. D. "The total synthesis of (-)-pre-swinholide A." Thesis, University of Cambridge, 1994. https://www.repository.cam.ac.uk/handle/1810/272650.

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11

Yang, Lai Hung. "Antifouling compounds from the marine sponge acanthella cavernosa and its associated microbes /." View abstract or full-text, 2006. http://library.ust.hk/cgi/db/thesis.pl?AMCE%202006%20YANG.

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12

Vijayan, Nidhi. "Bacterial Community Dynamics In Marine Sponge Cinachyrella kuekenthali Under Irradiance and Antibiotics." NSUWorks, 2015. http://nsuworks.nova.edu/occ_stuetd/393.

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The Marine sponge Cinachyrella sp used in this study are commonly found in offshore South Florida and Caribbean waters and appeared to be resilient in closed system aquaculture. Marine sponges host diverse bacterial symbionts that are distinct compared to bacteria found in ambient seawater, however the roles of a large fraction of the bacterial community in marine sponges are unknown. Comparison of symbiotic to aposymbiotic (bacteria-free) sponges could provide information about interactions (metabolic and physiologic) between the bacteria and sponge. In this study, a single Cinachyrella kueke
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13

Potens, Renee Michelle. "Characterization of the Marine Sponge Amphimedon compressa Microbiome Across a Spatial Gradient." NSUWorks, 2016. http://nsuworks.nova.edu/occ_stuetd/413.

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Diverse and ecologically important microbial communities (microbiomes) are symbiotic within marine sponges. In this study, the microbiome of Amphimedon compressa from three sample locations (Broward and Dade Counties, Southeast Florida, USA and the Southern Caribbean, Bocas del Toro, Panama) is characterized using 16S rRNA Illumina sequencing. The predominant taxa are Proteobacteria and Cyanobacteria, as expected for Low Microbial Abundance sponges, accounting for over 53% of the total microbiome community. The numbers of Operational Taxonomic Units (OTUs) decrease from Broward County (2,900)
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14

Tischler, Mark. "Terpenoids from the marine sponge Aplysilla glacialis and the nudibranch Cadlina luteomarginata." Thesis, University of British Columbia, 1989. http://hdl.handle.net/2429/31343.

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A chemical study of the pink encrusting sponge Aplysilla glacialis collected in Barkley Sound, B.C., has led to the isolation and structure elucidation of terpenes which are believed to be derived biogenetically from the hypothetical "spongian" precursor. In addition, the first example of a diterpene from a sponge containing a "marginatane" skeleton has been found. Cadlinolide A (75) was isolated and its structure elucidated by a combination of spectroscopic interpretation, chemical degradation, and confirmed by a single crystal x-ray diffraction analysis. The structure of a related metabolit
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15

Mapatha, Matlakala Reginah. "Discovery of biomolecules from South African marine sponge symbionts through Metagenomic studies." University of the Western Cape, 2018. http://hdl.handle.net/11394/5932.

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Magister Scientiae - MSc (Biotechnology)<br>Marine sponges are known to harbour diverse microorganisms which have been proposed to be involved in the synthesis of most of the natural compounds derived from sponges. However, only about 1% of these microorganisms can currently be identified through culturebased approaches, limiting the discovery of novel natural compounds. To overcome this limitation, a metagenomics approach has been introduced for the discovery of natural compounds from symbiotic bacterial metagenomic DNA.
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16

Tucker, David John, and n/a. "An Investigation of the Chemical Constituents of Two Species of Marine Sponge." Griffith University. Division of Science and Technology, 1990. http://www4.gu.edu.au:8080/adt-root/public/adt-QGU20050826.155059.

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An investigation of the dichioromethane extract of the sponge, Xestospongia testudinaria indicated that the extract was composed of approximately 40% sterols, 30% saturated fatty acids, 10% mono-unsaturated fatty acids and 20% poly-unsaturated acids. The sterol profile was found to vary between two collections of the sponge. In the first collection the major sterol was the C30 compound, xestosterol (4), which had not previously been reported to occur in this species. In the second collection there was a wider distribution of components with cholesterol (2a) being a major constituent and xestos
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17

Tucker, David John. "An Investigation of the Chemical Constituents of Two Species of Marine Sponge." Thesis, Griffith University, 1990. http://hdl.handle.net/10072/367459.

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An investigation of the dichioromethane extract of the sponge, Xestospongia testudinaria indicated that the extract was composed of approximately 40% sterols, 30% saturated fatty acids, 10% mono-unsaturated fatty acids and 20% poly-unsaturated acids. The sterol profile was found to vary between two collections of the sponge. In the first collection the major sterol was the C30 compound, xestosterol (4), which had not previously been reported to occur in this species. In the second collection there was a wider distribution of components with cholesterol (2a) being a major constituent and xestos
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18

Rao, T. S. P., N. S. Sarma, Y. L. N. Murthy, Venkata Siva Satya Narayana Kantamreddi, Colin W. Wright, and P. S. Parameswaran. "New polyhydroxy sterols from the marine sponge Callyspongia fibrosa (Ridley and Dendly)." Elsevier, 2010. http://hdl.handle.net/10454/4540.

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no<br>Four new polyhydroxylated sterols are isolated from Marine sponge Callyspongia fibrosa collected from the Gulf of Mannar, western Bay of Bengal (India). The structural assignment is based on 1H and 13C NMR spectra. All sterols are based on the known 24S-24-methyl cholesterol 1 which is also isolated, and contain 3b,6b-dihydroxy system and 25-O-acetate as common features (except in the case of sterol 6 that has a D25 in the place of 25-OAc). Additional OH substitution is also present at 5a in 4a and at 8b in 5. A further 12b-OH is present in 6 and 7. The hydroxylation pattern is so f
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19

McMurray, Steven E. "Demography of the giant barrel sponge Xestospongia muta in the Florida Keys." View electronic thesis, 2008. http://dl.uncw.edu/etd/2008-3/r1/mcmurrays/stevenmcmurray.pdf.

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20

Gomes, Hélder Alexandre Campos. "Ecological and biotechnological potential of sponge microbiome." Master's thesis, Universidade de Aveiro, 2015. http://hdl.handle.net/10773/15450.

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Mestrado em Biologia Molecular e Celular<br>Marine sponges harbor microbial communities of immense ecological and biotechnological importance. Recently, they have been focus of heightened attention due to the wide range of biologically active compounds with potential application, particularly, in chemical, cosmetic and pharmaceutical industries. However, we still lack fundamental knowledge of their microbial ecology and biotechnological potential. The development of high-throughput sequencing technologies has given rise to a new range of tools that can help us explore the biotechnological pote
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21

Halperin, Ari. "Distribution, Growth, and Impact of the Coral-Excavating Sponge, Cliona delitrix, on the Stony Coral Communities Offshore Southeast Florida." NSUWorks, 2014. http://nsuworks.nova.edu/occ_stuetd/26.

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Bioerosion is a major process that affects the carbonate balance on coral reefs, and excavating sponges from the genus Cliona are some of the most important bioeroders on Caribbean reefs. The orange boring sponge, Cliona delitrix, is an abundant excavating sponge offshore southeast Florida that frequently colonizes dead portions of live stony corals, killing live coral tissue as it grows. With the recent decline in coral cover attributed to combined environmental and anthropogenic stressors, the increasing abundance of excavating sponges poses yet another threat to the persistence of Caribbean
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22

Matobole, Relebohile Matthew. "Matrix comparison of isolation conditions for secondary metabolite producing marine sponge associated bacteria." University of the Western Cape, 2015. http://hdl.handle.net/11394/4754.

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>Magister Scientiae - MSc<br>The discovery of novel secondary metabolites has declined significantly in recent years whereas there is a rise in the number of multi-drug resistant pathogens and other types of diseases. The decline in natural product discovery was due to high rediscovery of already known compounds and the costs in developing natural products. As a result pharmaceutical companies lost interest in investing in natural product discovery. However, there is a renewed interest in marine sponge associated microorganisms as a rich and untapped source of secondary metabolites. The object
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23

Kim, Tae Kyung. "Bioactive compound-producing symbiotic bacteria from marine sponge species : cultural, gene retrieval, and metagenomic studies /." [St. Lucia, Qld.], 2006. http://www.library.uq.edu.au/pdfserve.php?image=thesisabs/absthe19506.pdf.

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24

Brastianos, Harry Charilaos. "Bioactive natural products from nature." Thesis, University of British Columbia, 2007. http://hdl.handle.net/2429/3960.

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Bioassay guided fractionation of a crude extract of the marine sponge Neopetrosia exigua resulted in the first reported isolation of exiguamines A and B. These pyrroloquinone alkaloids have an unprecedented hexacyclic skeleton that has not been previously encountered in natural products. Biological studies have identified exiguamine A as a potent in vitro inhibitor of the enzyme indoleamine-2,3-dioxygenase (IDO). IDO is an enzyme expressed by tumor cells to evade the immune system. Inhibitors against this enzyme may allow the immune system to attack cancer cells, making this enzyme a potential
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25

Ross, Andrew R. "Studies towards the synthesis of Popolohuanone E." Thesis, University of Glasgow, 1997. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.388550.

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26

Critcher, Douglas James. "The total synthesis of neohalicholactone." Thesis, University of Bath, 1995. https://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.296300.

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27

Chak, Tin Chi Solomon. "Reproductive Altruism, Social Diversity and Host Association in Sponge-Dwelling Snapping Shrimps, Synalpheus." W&M ScholarWorks, 2016. https://scholarworks.wm.edu/etd/1477068130.

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The diversity of animal social strategies has interested evolutionary biologists since the time of Darwin. Eusociality—the apex of animal sociality—traditionally characterized by cooperative offspring care, overlapping generations and reproductive division of labor, was until recently known only in insects and a few vertebrate species. The independent evolution of eusociality in shrimps in the genus Synalpheus offers a unique opportunity to test the generality of social evolution theories that are based mainly on insects and social vertebrates. The genus Synalpheus is particularly ideal for co
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28

Sjögren, Martin. "Bioactive compounds from the marine sponge Geodia barretti : characterization, antifouling activity and molecular targets /." Uppsala : Acta Universitatis Upsaliensis : Universitetsbiblioteket [distributör], 2006. http://urn.kb.se/resolve?urn=urn:nbn:se:uu:diva-6797.

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29

Cicirelli, Elisha M. "Bacterial quorum-sensing in the marine sponge environment implications on motility and flagellar biosynthesis /." [Bloomington, Ind.] : Indiana University, 2007. http://gateway.proquest.com/openurl?url_ver=Z39.88-2004&rft_val_fmt=info:ofi/fmt:kev:mtx:dissertation&res_dat=xri:pqdiss&rft_dat=xri:pqdiss:3297116.

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Thesis (Ph.D.)--Indiana University, Dept. of Biology, 2007.<br>Title from dissertation home page (viewed Sept. 29, 2008). Source: Dissertation Abstracts International, Volume: 69-02, Section: B, page: 0818. Adviser: Clay Fuqua.
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30

Witowski, Chris G. "Investigation of Bioactive Metabolites from the Antarctic Sponge Dendrilla membranosa and Marine Microorganisms." Scholar Commons, 2015. https://scholarcommons.usf.edu/etd/5602.

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Natural products continue to be a valuable source of compounds in research involving chemical ecology and drug discovery. Secondary metabolites are biosynthesized to benefit the host organism in its environment (feeding deterrence from predators, antibiotic properties to avoid infection, etc.) but these compounds also serve as useful scaffolds in drug discovery applications. The research herein describes both aspects of these two branches of natural products chemistry. The Antarctic sponge Dendrilla membranosa produces diterpenes, of which membranolide A, deters feeding of the predatory amphip
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31

Olsen, Elisabeth, Cerf Christopher De, Godwin Dziwornu, et al. "Cytotoxic activity of marine sponge extracts from the sub-Antarctic Islands and the Southern Ocean." South African Journal of Science, 2016. http://hdl.handle.net/10962/66300.

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publisher version<br>Over the past 50 years, marine invertebrates, especially sponges, have proven to be a valuable source of new and/or bioactive natural products that have the potential to be further developed as lead compounds for pharmaceutical applications. Although marine benthic invertebrate communities occurring off the coast of South Africa have been explored for their biomedicinal potential, the natural product investigation of marine sponges from the sub-Antarctic Islands in the Southern Ocean for the presence of bioactive secondary metabolites has been relatively unexplored thus fa
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32

McQuillan, Lea. "Species richness, density and cover of sponge assemblages on temperate reefs off Perth, Western Australia." Thesis, Edith Cowan University, Research Online, Perth, Western Australia, 2006. https://ro.ecu.edu.au/theses/359.

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Sponges were the dominant faunal benthic group, occupying 30 -50% of the limestone reef surface and displaying high diversity (>240 sponge species) on subtidal temperate reefs off Perth, Western Australia. Despite this high diversity there was little variation in composition among the six different sites sampled. However, there was within-site heterogeneity of sponge assemblages which has been ascribed to small-scale variation in light and sedimentation/abrasion rates. Differences in sponge assemblages were also detected between sampling times, species richness and sponge density were hi
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33

Sjögren, Martin. "Bioactive Compounds from the Marine Sponge Geodia barretti : Characterization, Antifouling Activity and Molecular Targets." Doctoral thesis, Uppsala universitet, Institutionen för läkemedelskemi, 2006. http://urn.kb.se/resolve?urn=urn:nbn:se:uu:diva-6797.

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The marine sponge Geodia barretti produces a range of secondary metabolites. Two of these compounds were isolated and elucidated guided by their ability to inhibit settlement of cypris larvae of the barnacle Balanus improvisus. The compounds barettin (cyclo-[(6-bromo-8-en-tryptophan)-arginine]) as E/Z mixture and 8,9-dihydrobarettin (cyclo-[6-bromo-tryptophan)-arginine]) were determined by using mass spectrometry, nuclear magnetic resonance and quantitative amino acid analysis.The bioactivity of these brominated dipeptides is in the range of antifouling substances used today: EC50 values of 0.
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34

Patel, Jignasa. "Meta-Transcriptome Profiles of the Marine Sponge, Axinella corrugata and its Microbial Consortia: A Pyrosequencing Approach." NSUWorks, 2012. http://nsuworks.nova.edu/occ_stuetd/174.

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Marine micro-organisms are important components of various biogeochemical cycles, complex food webs and ecological niches. Metagenomic sequencing can provide rapid profile of metabolic activities within the sponge and resident microbes. However, the study of metatranscriptomes from sponges using high throughput sequencing technology has only recently begun. Through this study we isolated, characterized and compared metatranscriptome profiles of Axinella corrugata host and sponge-specific microbial communities using 454 pyrosequencing technology. Four cDNA libraries (two eukaryotic and two prok
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35

Johnson, Tyler A. "A comprehensive reinvestigation into the bioactive secondary metabolites of an Indo-Pacific marine sponge: Cacospongia mycofijiensis /." Diss., Digital Dissertations Database. Restricted to UC campuses, 2008. http://uclibs.org/PID/11984.

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36

Jadulco, Raquel C. "Isolation and structure elucidation of bioactive secondary metabolites from marine sponges and sponge derived fungi (Isolierung und strukturelle Identifizierung von biologisch aktiven Naturstoffen aus marinen Schwämmen und aus Schwämmen isolierte Pilze) /." Doctoral thesis, [S.l. : s.n.], 2002. https://nbn-resolving.org/urn:nbn:de:bvb:20-opus-3565.

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Low-molecular mass natural products from bacteria, fungi, plants and marine organisms exhibit unique structural diversity which are of interest for the identification of new lead structures for medicinals and agrochemicals. In the search for bioactive compounds from marine sponges and sponge-associated fungi, this research work resulted to the isolation of twenty-six compounds, eight of which are new metabolites. The sponges were collected from the Indo-pacific regions, particularly those from Indonesian and Philippine waters, as well as those from the Mediterranean Sea near the island of Elba
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37

DeBiasse, Melissa B. "Genetic Connectivity and Phylogeography of the Branching Vase Sponge (Callyspongia vaginalis) Across Florida and the Caribbean." NSUWorks, 2008. http://nsuworks.nova.edu/occ_stuetd/255.

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Chapter 1 The only coral reef ecosystem in the continental USA occurs off southeastern Florida and is under considerable strain due to intense urbanization and coastal development in this region. Coherent management and conservation efforts for this rapidly degrading ecosystem will benefit from knowledge about the patterns of genetic connectivity along the entire Florida reef tract. Because of their substantial biomass and extensive species diversity, the Porifera are an important model for investigating connectivity among coral reefs in Florida. We determined the genetic population structure
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38

Smith, Emily. "De novo Transcriptome Analysis of the Marine Sponge Cinachyrella spp: A Potential Model Organism for Oil and Dispersant Ecotoxicology." NSUWorks, 2013. http://nsuworks.nova.edu/occ_stuetd/141.

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In order to study the potential effects of an oil spill on coral reef organisms, the marine sponge, Cinachyrella spp. was investigated. In this study, Cinachyrella spp. was placed in a closed aquaculture system and exposed to sub-lethal water-accommodated fractions (WAFs) of Macondo crude oil and chemically-enhanced water accommodated fractions (CE-WAFs) of the dispersant, Corexit 9500, over a 24-hour time course, in order to model the BP Deepwater Horizon oil spill and oil spill sponge response. Illumina RNA sequencing and gene expression analysis utilizing hierarchical clustering, principal
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39

Price, Jessica. "Species Richness, Diversity, and Abundance of Sponge Communities in Broward County, Florida, 2000-2015." Thesis, NSUWorks, 2018. https://nsuworks.nova.edu/occ_stuetd/494.

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Sponges (Porifera) are a major component of coral reef ecosystems. They outnumber coral species on the Florida Reef Tract, and in places, account for more living cover. Because coral reefs are a vital part of Florida’s economy, it is important to understand how local sponge assemblages vary spatially and temporally, especially as corals continue to decline. However, long-term observations of sponge assemblages (species richness, diversity and abundance) are lacking. To address this, annual photoquadrats were analyzed from a series of 25 sites off Broward County between 2000 and 2015. Variation
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40

Hassanzada, Caidra Elizabeth. "Biodiversity and Ecological Dynamics of Sciophilous Benthic Communities on Artificial Plates: Emphasis on Reef Sponges." NSUWorks, 2015. http://nsuworks.nova.edu/occ_stuetd/390.

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Low light intensity habitats harbor unique sciophilous benthic communities and are a source of novel and unique sponge fauna. However, the community structure of these habitats is poorly studied to date. Thus, this study attempts to understand the composition and structure of sciophilous sponge populations in southeast Florida. Fifty limestone plates were placed on a shallow reef in Fort Lauderdale for two years (2010-2012). To identify the sponge community and their patterns over time, all plates were photographed at the end of each year. Then, samples were taken from each of the live sponge
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41

Uria, Agustinus Robert [Verfasser]. "Investigating Natural Product Biosynthesis in Uncultivated Symbiotic Bacteria of the Marine Sponge Theonella swinhoei / Agustinus Robert Uria." Bonn : Universitäts- und Landesbibliothek Bonn, 2013. http://d-nb.info/104809149X/34.

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42

Wilson, Anthony James. "Synthesis of novel inhibitors of CDK 4 / Cyclin D1 based on the natural marine sponge pigment fascaplysin." Thesis, University of Leicester, 2009. http://hdl.handle.net/2381/4531.

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This thesis describes an investigation into the design and synthesis of novel inhibitors of the cell-cycle regulatory enzyme CDK4/Cyclin D1 utilising the structure of the natural product fascaplysin as a lead compound. The structure activity relationship of fascaplysin (i) has been investigated and its structure simplified and rationalised to give novel inhibitor pharmacophores based on structures (ii) and (iii). Inhibitors of structure (ii) were found to possess activity against CDK4/Cyclin D1 of IC50 51-176 μM and to be approximately 15-20 fold selective over CDK2/Cyclin A. The second genera
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43

Jahn, Martin Thomas [Verfasser], Ute [Akademischer Betreuer] Hentschel, and Thomas [Gutachter] Bosch. "Physiology, syntrophy and viral interplay in the marine sponge holobiont / Martin Thomas Jahn ; Gutachter: Thomas Bosch ; Betreuer: Ute Hentschel." Kiel : Universitätsbibliothek Kiel, 2019. http://d-nb.info/1202631517/34.

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44

McGrath, Emily Christine. "The Feasibility of Rubble-Binding Sponge Propagation for Use in Reef Restoration." Thesis, NSUWorks, 2012. https://nsuworks.nova.edu/occ_stuetd/176.

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A common injury type associated with vessel groundings on coral reefs is generation of coral rubble. As a substrate rubble is dynamic and can be mobilized by normal wave agitation, causing secondary damage to surviving corals and preventing coral larvae and invertebrates from surviving. Typical rubble management options include offsite removal and onsite stabilization using artificial materials. Sponges show promise as a restoration tool for rubble stabilization, especially sponges that are known to have rapid regeneration rates, low mortality, and the capability to quickly form attachment poi
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MAZZELLA, VALERIO. "Microbiome, metabolic and phenotypic traits in the adaptability of marine sponges to Ocean Acidification." Doctoral thesis, Università Politecnica delle Marche, 2021. http://hdl.handle.net/11566/291001.

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Il progressivo incremento delle emissioni di CO2 in atmosfera dovuto alle attività antropiche ed il conseguente assorbimento da parte degli oceani stanno determinando importanti modificazioni del sistema carbonatico e una diminuzione del pH nei mari a livello globale. Questo fenomeno, noto come acidificazione oceanica, è atteso determinare nei prossimi decenni profonde modificazioni della biodiversità e nel funzionamento degli ecosistemi marini. In particolare, ci si aspetta un forte declino degli organismi calcificanti, mentre organismi non calcificanti, o fototrofi potrebbero essere favoriti
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Noguez, Jaime Heimbegner. "Chemical Investigation of the Antarctic Marine Invertebrates Synoicum adareanum and Artemisina plumosa." Scholar Commons, 2010. http://scholarcommons.usf.edu/etd/3453.

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Of the small percentage of organisms chemically investigated over the years as potential sources of natural products, much less is known about those from the marine realm. Despite the lack of attention they have received in comparison to terrestrial organisms, marine life have recently been found to represent a valuable source for novel bioactive compounds. Cold water marine habitats are home to a plethora of organisms that have the ability to produce secondary metabolites that exhibit a great deal of diversity in both their chemical structures and biological activities. The chemical investiga
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47

Peddycoart, Melinda R. "Variations in Composition, Abundance and Cover of Reef Tract Sponge Assemblages in Broward County, Florida, 2002-2006." NSUWorks, 2010. http://nsuworks.nova.edu/occ_stuetd/210.

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Sponges are major macrofaunal components of coral reef ecosystems, often outnumbering corals in richness, abundance and coverage. Although reefs along southeastern Florida have exhibited substantial deterioration over the last few decades and are currently under intensive scrutiny, most investigations have omitted sponges. This study focuses on reef sponge assemblages along Broward County, Florida, from 2002 through 2006 and examines changes in sponge assemblage composition, areal coverage and abundance over time. The photographic database derives from an ongoing study of stony and soft coral
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Bush, Stephanie J. "Post-Injury Recovery, Reattachment, Survival and Growth of the Giant Barrel Sponge, Xestospongia muta, Offshore Southeast Florida." NSUWorks, 2012. http://nsuworks.nova.edu/occ_stuetd/193.

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The giant barrel sponge, Xestospongia muta is a prominent component in southeast Florida reef communities and is often injured from anthropogenic or natural disturbances. The resulting complete or partial shearing of X. muta barrels frequently leads to mortality of loose fragments that do not typically reattach. This study examines the degree to which sponge size and injury severity affects recovery and growth, and explores artificial reattachment success and growth of fragments. In June 2008, 65 sponges were subjected to injury treatments of approximately 50% or 90% barrel removal. A new, sim
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Martins, Maria Gleiciane De Queiroz. "BioprospecÃÃo de proteÃnas da esponja marinha Aaptos sp. por anÃlise proteÃmica." Universidade Federal do CearÃ, 2015. http://www.teses.ufc.br/tde_busca/arquivo.php?codArquivo=14290.

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CoordenaÃÃo de AperfeiÃoamento de Pessoal de NÃvel Superior<br>As esponjas marinhas constituem uma rica reserva de substÃncias naturais, muitas delas de imenso interesse biotecnolÃgico. Elas compreendem um grupo promissor no fornecimento de compostos bioativos para a humanidade. Desta forma, pesquisas de novas drogas de fontes naturais sugerem que as esponjas marinhas possuem importantes compostos bioativos com ponteciais: farmacolÃgico, antimicrobiano; antitumoral; antiviral; antiinflamatÃrio; imunossupresor; cardiovascular; neurosupressor; relaxante muscular bem como biomarcador de poluiÃÃo.
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Martins, Maria Gleiciane De Queiroz. "Bioprospecção de proteínas da esponja marinha Aaptos sp. por análise proteômica." reponame:Repositório Institucional da UFC, 2015. http://www.repositorio.ufc.br/handle/riufc/18736.

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MARTINS, Maria Gleiciane De Queiroz. Bioprospecção de proteínas da esponja marinha Aaptos sp. por análise proteômica. 2015. 67 f. : Tese (doutorado) - Universidade Federal do Ceará, Centro de Ciências Agrárias, Departamento de Engenharia de Pesca, Fortaleza-CE, 2015<br>Submitted by Nádja Goes (nmoraissoares@gmail.com) on 2016-07-27T14:14:45Z No. of bitstreams: 1 2015_tese_mgqmartins.pdf: 1676608 bytes, checksum: 5949b16ede3a943dff4e0208ea167426 (MD5)<br>Approved for entry into archive by Nádja Goes (nmoraissoares@gmail.com) on 2016-07-27T14:15:02Z (GMT) No. of bitstreams: 1 2015_tese_mgqmartin
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