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Journal articles on the topic 'Marrubium vulgare L'

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Published: 3 June 2025
Last updated: 13 July 2025

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1

Bonilla Rivera, Pablo, Gustavo Fernandez Rebaza, Analucia Toche Tuesta, et al. "Determinación estructural de flavonas presentes en el extracto metanólico de hojas de Marrubium vulgare L. "Cordon"." Revista Peruana de Medicina Integrativa 4, no. 3 (2019): 90–95. http://dx.doi.org/10.26722/rpmi.2019.v4n3.499.

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Objetivo. Determinar la estructura química de flavonas aisladas del extracto metanólico de hojas de Marrubium vulgare L. “Cordón”, mediante comparación con lo publicado por TJ Mabry. Materiales y métodos. Se elaboró extracto metanólico de hojas de Marrubium vulgare L. “Cordón” . Se determinó su solubilidad en solventes de polaridad creciente. Se detectaron los componentes químicos utilizando tricloruro férrico, reactivo de Shinoda, gelatina, entre otros reactivos cromogénicos. Se realizó cromatografía en capa fina y por espectroscopía UV/VIS se propusieron estructuras químicas para los metabolitos tipo flavonas presentes en el extracto metanólico de hojas de Marrubium vulgare L. “Cordón” . Resultados. El extracto metanólico de hojas de Marrubium vulgare L. “Cordón” fue soluble en solventes de mediana polaridad. Los metabolitos secundarios encontrados fueron flavonoides, taninos y alcaloides. Se propusieron estructuras químicas de flavonas a través del análisis de los espectros UV/Vis, y por comparación con tablas publicadas en la literatura. Conclusiones. Se determinaron nueve estructuras químicas de metabolitos secundarios tipo flavonas del extracto metanólico de hojas de Marrubium vulgare L. “Cordón” mediante comparación con lo publicado por TJ Mabry.Palabras clave: Marrubium vulgare L.; Tamizaje fitoquímico; Cromatografía; Espectroscopia UV/Vis; Flavonas (Fuente: DeCS
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2

Aćimović, Milica, Katarina Jeremić, Nebojša Salaj, et al. "Marrubium vulgare L.: A Phytochemical and Pharmacological Overview." Molecules 25, no. 12 (2020): 2898. http://dx.doi.org/10.3390/molecules25122898.

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Marrubium vulgare is a plant with high bioactive potential. It contains marrubiin, a labdane diterpene that is characteristic for this genus, as well as a complex mixture of phenolic compounds. According to numerous studies, M. vulgare acts as a good antioxidant agent, and due to this, it could potentially be useful in treatments of cancer, diabetes mellitus, and liver diseases. In addition, its anti-inflammatory, wound-healing, antihypertensive, hypolipidemic, and sedative potential are discussed. Apart from that, its antimicrobial activity, especially against Gram+ bacteria, fungi, herpes simplex virus, and parasites such as Toxoplasma gondii, Trichomonas vaginalis, and Plasmodium berghei-berghei was recorded. Additionally, it could be used as a chicken lice repellent, herbicide, and natural insecticide against mosquito larvae and natural molluscicide. In veterinary medicine, M. vulgare can be used as an anthelmintic against the eggs and larvae of bovine strongyles parasites, and as an antibiotic against bovine mastitis caused by resistant bacterial strains. Due to the mentioned benefits, there is a tendency for the cultivation of M. vulgare in order to ensure high-quality raw material, but more firm scientific evidence and well-designed clinical trials are necessary for the well-established use of M. vulgare herb and its preparations.
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3

V.O., Derkach, and Rakhmetov D.B. "Introduction of the Marrubium vulgare L. for cultivation in the Left-Bank of Forest-Steppe of Ukrain." Plant Introduction 59 (September 1, 2013): 43–47. https://doi.org/10.5281/zenodo.1579546.

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The features of ontogenesis, productive potential and adaptive possibilities of the introduced species of white horehound <em>Marrubium vulgare</em> L. have been investigated. Possibilities of cultivating plants under the conditions of the Left-Bank of Forest-Steppe of Ukraine are demonstrated. The productivity of raw material (air-dry grass) and seeds in the first year and following years are investigated. The contents of the pharmacological active substances in the <em>Marrubium vulgare</em> are determinate.
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4

Yousefi, Keyvan, Sanaz Hamedeyazdan, Mohammadali Torbati, and Fatemeh Fathiazad. "Chromatographic Fingerprint Analysis of Marrubiin in Marrubium vulgare L. via HPTLC Technique." Advanced Pharmaceutical Bulletin 6, no. 1 (2016): 131–36. http://dx.doi.org/10.15171/apb.2016.019.

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5

Abadi, Abderazak, and Aicha Hassani. "Chemical Composition and Antibacterial Activity of Essential Oil of Marrubium vulgare from Eastern Algeria." International Letters of Chemistry, Physics and Astronomy 15 (September 2013): 61–69. http://dx.doi.org/10.18052/www.scipress.com/ilcpa.15.61.

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The essential oil from flowering Marrubium (Marrubium vulgare L.) an aromatic member of the Lamiaceae family, from Algeria, obtained by hydrodistillation, was analysed by GC/FID and GC/MS. The constituents were identified by their mass spectra and Kovats’ indices. Fivety (50) components in the oil of M. vulgare were identified. The results demonstrated that the major components of the essential oil were: 4,8,12,16-Tetramethyl heptadecan-4-olid (16.97%), Germacrene D-4-ol (9.61%), α- pinéne (9.37%), Phytol (4.87%), Dehydro-sabina ketone (4.12%), Piperitone (3.27%), δ-Cadinene (3.13%), 1-Octen-3-ol (2.35%) and Benzaldehyde (2.31%). Essential oil of M vulgare was evaluated for its antibacterial activities against Gram-positive and Gram negative pathogenic bacteria: Bacillus subtilis, Micrococcus luteus, Escherichia coli and Klebsiella pneumoniae.
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6

Abadi, Abderazak, and Aicha Hassani. "Chemical Composition and Antibacterial Activity of Essential Oil of<i> Marrubium vulgare</i> from Eastern Algeria." International Letters of Chemistry, Physics and Astronomy 15 (June 29, 2013): 61–69. http://dx.doi.org/10.56431/p-62hf43.

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The essential oil from flowering Marrubium (Marrubium vulgare L.) an aromatic member of the Lamiaceae family, from Algeria, obtained by hydrodistillation, was analysed by GC/FID and GC/MS. The constituents were identified by their mass spectra and Kovats’ indices. Fivety (50) components in the oil of M. vulgare were identified. The results demonstrated that the major components of the essential oil were: 4,8,12,16-Tetramethyl heptadecan-4-olid (16.97%), Germacrene D-4-ol (9.61%), α- pinéne (9.37%), Phytol (4.87%), Dehydro-sabina ketone (4.12%), Piperitone (3.27%), δ-Cadinene (3.13%), 1-Octen-3-ol (2.35%) and Benzaldehyde (2.31%). Essential oil of M vulgare was evaluated for its antibacterial activities against Gram-positive and Gram negative pathogenic bacteria: Bacillus subtilis, Micrococcus luteus, Escherichia coli and Klebsiella pneumoniae.
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7

Dib, Kaoutar, Yahia Cherrah, Sana Rida, Abdelkarim Filali-Maltouf, and OumKeltoum Ennibi. "In Vitro Antibacterial Activity of Myrtus communis L. and Marrubium vulgare L. Leaves against Aggregatibacter actinomycetemcomitans and Eikenella corrodens." Evidence-Based Complementary and Alternative Medicine 2021 (October 19, 2021): 1–8. http://dx.doi.org/10.1155/2021/8351332.

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Background and Objectives. It has been shown that Myrtus communis and Marrubium vulgare have antibacterial activity against bacterial and fungal strains of different diseases. This study aimed to evaluate in vitro the antibacterial activity of aqueous and methanolic extracts of Myrtus communis and Marrubium vulgare leaves against selected periodontal pathogens. Materials and Methods. Clinical strains of Aggregatibacter actinomycetemcomitans and Eikenella corrodens and two reference strains of A. actinomycetemcomitans were tested. The antibacterial activity of each studied plant extract was evaluated using agar diffusion and broth microdilution assays. Results. Both aqueous and methanolic extracts of M. communis exhibited high antibacterial activity against periodontal pathogens as compared to M. vulgare extracts. At concentrations of 2.5-0.32 mg/disc, inhibition zones of the methanolic extract of M. communis ranged from 19.66 ± 0.57 to 12.33 ± 0.57 mm. The methanolic extract of M. vulgare showed at concentrations of 5-0.63 mg/disc inhibition zones ranging from 15.66 ± 0.57 to 12 ± 0.00 mm. Its aqueous extract at concentration of 0.63 mg/disc showed no antimicrobial activity against the clinical and reference strain of A. actinomycetemcomitans. Conclusion. This study showed that methanolic and aqueous extracts of M. communis and M. vulgare have in vitro an antibacterial activity against periodontal pathogens. They could be use as ingredients of an oral antimicrobial agent for prevention or treatment of periodontal diseases. Further research on isolating the compounds from these plant extracts and their toxicity effect could be conducted.
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8

Bahammou, Younes, El Houssayne Bougayr, Said Bajji, et al. "Thermodynamic Sorption Study of a Medicinal Plant Using the Standard Static Gravimetric Method for a Better Conservation." Journal of Biomimetics, Biomaterials and Biomedical Engineering 67 (January 15, 2025): 45–62. https://doi.org/10.4028/p-xlog9j.

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Aromatic and medicinal plants are a natural source of pharmaceutical compounds with curative and therapeutic properties. They have been used for centuries to treat various ailments and offer alternative options to conventional treatments. Among these plants, Marrubium vulgare L., which is widely used in traditional medicine for diabetes treatment, has antioxidant potential as well as anti-inflammatory, healing, and soothing properties, attracting increasing medical interest. In this context, the hygroscopic behavior of Marrubium vulgare L. is reported. The adsorption-desorption isotherms of Marrubium vulgare leaves were determined using the standard static gravimetric method at three temperatures (30, 40, and 50 °C) to ensure physicochemical and microbiological stability throughout the storage process. The results showed that the adsorption-desorption isotherms of all samples followed a sigmoidal pattern, consistent with other agricultural products discussed in the literature. The optimal moisture content for conservation was also determined. The GAB (Guggenheim-Anderson-de Boer) and double polynomial models were the most suitable for describing the sorption curves. The adsorption-desorption data were examined to determine the moisture content of the monolayer (3.4-9.7%), properties of sorbed water in porous structures and surfaces, total heat of wetting, net isosteric heat of sorption, spreading pressure, differential entropy, and enthalpy-entropy compensation. It was also observed that the spreading pressure and average pore radius increase with rising relative humidity and temperature, leading to the appearance of defects on the surface of Marrubium vulgare leaves. Compensation theory is essential to consider when evaluating the impact of temperature on the adsorption-desorption properties. The Gibbs free energy was positive for sorption, indicating that the process is non-spontaneous.
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9

MA, MIN, QING-HAI FAN, and ZHI-QIANG ZHANG. "Ontogenetic changes in the morphology of Eharius chergui (Acari: Phytoseiidae)." Zootaxa 4540, no. 1 (2018): 23. http://dx.doi.org/10.11646/zootaxa.4540.1.5.

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The morphological ontogeny of Eharius chergui (Athias-Henriot, 1960) is described in this paper based on laboratory-reared specimens originating from Marrubium vulgare L. (Lamiaceae) collected in North Island, New Zealand. Malformation was observed in the development of some idiosomal setae in some specimens and was suggested to be related to the host plant M. vulgare.
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10

Ahmed, Abderrazzak Baba, and Tahar Kebi. "Phytochemical Screening and Evaluation of Heavy Metals in a Medicinal Plant Marrubium Vulgare L." International Journal of Circuits, Systems and Signal Processing 17 (March 13, 2023): 107–11. http://dx.doi.org/10.46300/9106.2023.17.13.

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Our research is part of the enhancement of our plant heritage that we deemed necessary to exploit it, our choice fell on a medicinal plant Marrubium vulgare L and this by the phytochemical characterization (of leaves, stems and roots) followed by the study of the xerophytic character, by determining the content of five heavy metals (Zinc, Copper, Cadmium, Lead and Chromium)in the different organs and by analysis with atomic absorption spectrometry (AAS). The results of the phytochemical tests showed the richness in secondary compounds, namely: flavonoids, tannins, saponosides, coumarins and reducing compounds. heavy metal analyzes showed that Marrubium vulgare L was found to have a high capacity to accumulate heavy metals, especially chromium and copper. The levels of its heavy metals are within the toxic threshold of plants.
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11

Moulay, M., F. Labdelli, F. Bousmaha, M. Adamou Djerbaoui, R. Bouteldja, and R. Doucene. "Physicochemical and phytochemical study Ofmarrubium vulgarel. (Lamiaceae family)." Journal of Fundamental and Applied Sciences 12, no. 2 (2023): 728–37. http://dx.doi.org/10.4314/jfas.v12i2.14.

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Marrubium vulgare L. is a spont aneous plant of great medicinal value due to the presence of secondary metabolites. Our work aims to study the physicochemical and phytochemical profile of this species. The results of the physicochemical analyzes showed that Marrubium vulgare L. has a sug ar content of 5.91%, a lipid content of 4.12%, a total fiber content o f 6.42%, a water content of 42. 42%, an ash content of 17.76%, a solids content of 2.5 degrees of Brix, an electrical conductivity of 4.06 mS/cm 2 and a pH of 4.8. Regarding the results of the various phytochemical tests, the latter revealed the presence of catholic tannins, saponins, flavonoids, alkaloids and mucilage in the horehound. However, the absence of anthocyanins, glycosides, quinones, anthraquinones and irroids has been noted.
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12

Derkach, V., and N. Kutsenko. "Ecological effect of common horehound cultivation (Marrubium vulgare L.)." Agroecological journal, no. 2 (June 17, 2016): 46–49. http://dx.doi.org/10.33730/2077-4893.2.2016.248310.

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The predictable positive effects from the cultivation of indigenous medicinal plant White horehound (Marrubium vulgare) are present. It is proved that red the cultivation of plants in the crop on large areas will not only provide domestic pharmaceutical enterprises with medicinal raw materials and reduce the load on the plant communities on the harvesting of plants, but also will increase the biodiversity and sustainability of agricultural lands. Due to the presence of sugar nectar in the flowers and a long flowering period of the aftermath after the procurement of raw materials it is expected significantly improving of quality and performance of apiaries products. Perennial crops of White horehound ordinary due to the peculiarities of the structure of the root system of plants are able to resist water and wind erosion of soil.
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13

Sahpaz, Sevser, Thierry Hennebelle, and François Bailleul. "Marruboside, a New Phenylethanoid Glycoside from Marrubium Vulgare L." Natural Product Letters 16, no. 3 (2002): 195–99. http://dx.doi.org/10.1080/10575630290013576.

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14

Niedenthal, Tobias, and Johannes Mayer. "„Der weisse Andorn ist zur Lungesucht gar gut“." Zeitschrift für Phytotherapie 38, no. 06 (2017): 253–57. http://dx.doi.org/10.1055/s-0043-122334.

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Zusammenfassung Der Gewöhnliche oder Weiße Andorn (Marrubium vulgare L.) gehörte von der Antike bis weit in die Neuzeit zu den bedeutendsten Heilpflanzen in Europa. Trotz positiver Monografien von Kommission E, ESCOP und HMPC ist der Andorn heute weitgehend aus dem Blickfeld der Phytotherapie verschwunden.
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15

KANYONGA, M. P., T. MUJANGI, and N. KAVUNGA. "Impact of the methanolic extract of Marrubium vulgare on biochemical parameters of Wistar rats." REVUE DES SCIENCES DE LA SANTE 3, no. 1 (2024): 11–13. https://doi.org/10.71004/rss.024.v3.i1.23.

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Evaluation de l’effet de l’extrait méthanolique de Marrubium vulgare (Utilisé traditionnellement comme antidiabetique, antihypertension et pour soigner plusieurs maladies), sur les Rats wistar males. Ces animaux ont été subdivisés en 4 groupes (n=6) et l’extrait méthanolique de Marrubium vulgare a été administré à de doses de 50, 100 et 200 mg/Kg de poids corporel d’animal en expérimentation, pendant 21 jours. Puis, le sang des animaux a été prélevé à partir de la ponction cardiaque, afin d’obtenir le sérum, qui a permis de mesurer les paramètres biochimiques. Les résultats obtenus n’ont pas montré un changement significatif (p ˂ 0.05) pour les paramètres dosés : cholestérol, bilirubine, glucose, protéine, urée, phosphatase alcaline et de transaminase (ASAT). Alors que le taux d’Alanine Transaminase (ALAT) pour les groupes des rats ayant reçu 100 et 200 mg/Kg de poids corporel (16.44 et 14.94U/L respectivement) a montré une différence significative (p ˂ 0.05) quand on le compare avec le taux d’animaux de control 25.36 U/L et ceux traité à 50mg/Kg de poids corporel (17.2 U/L).
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DÖKER, İSMAIL. "Two new species of Eharius Tuttle & Muma (Acari: Phytoseiidae) from Turkey, with a key to world species." Zootaxa 4413, no. 3 (2018): 482. http://dx.doi.org/10.11646/zootaxa.4413.3.3.

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Two new species of the genus Eharius Tuttle &amp; Muma (Acari: Phytoseiidae), Eharius karuti sp. nov. and Eharius stathakisi sp. nov. are described and illustrated, based on specimens collected from Phlomis sp. and Marrubium vulgare L. (Lamiaceae) from Turkey. A key to the known species of the genus is provided.
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17

Mssillou, Ibrahim, Abdelkrim Agour, Meryem Slighoua, et al. "Ointment-Based Combination of Dittrichia viscosa L. and Marrubium vulgare L. Accelerate Burn Wound Healing." Pharmaceuticals 15, no. 3 (2022): 289. http://dx.doi.org/10.3390/ph15030289.

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Burns constitute a major challenge in medical science, and plants can be part of the solution. Dittrichia viscosa L. (Asteraceae) and Marrubium vulgare L. (Lamiaceae) are widely used in Moroccan traditional medicine to treat several diseases and possess high potency to cure wounds. This study aimed to investigate in vivo the analgesic, anti-inflammatory, and burn-healing effects of both plants and their mixture. The hydro-ethanolic extract of both plants was analyzed using high-performance liquid chromatography with diode-array detection (HPLC-DAD). Burns were conducted on dorsal part of rats, and the wound healing process was evaluated during 21 days. Gallic acid, caffeic acid, ferulic acid, and quercetin were identified in M. vulgare extract. The analysis recorded the presence of caffeic acid, rosmarinic acid, rutin, and quercetin in D. viscosa. The group treated with the mixture showed the lowest abdominal contractions (30.4 ± 7.52) with the highest percentage of inhibition (69.12 ± 7.04%). The inhibition of paw inflammation for M. vulgare was 47.65%, followed by D. viscosa (33.86%) and the mixture (30.41%). The mixture showed the highest wound contraction at day 7 (33.16 ± 14.33%) and day 14 (87.54 ± 3.98%). D. viscosa showed the highest wound contraction on the 21st day (99.28 ± 0.44%). In conclusion, both plants and their combination showed promising results for burn healing.
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18

N. A. M. Ali, Abdallah, S. A. S. "Application of Tissue Culture Technique on Marrubium vulgare L. Plant." Hortscience Journal of Suez Canal University 7, no. 1 (2018): 1–10. http://dx.doi.org/10.21608/hjsc.2018.58303.

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19

Lodhi, Santram, Gautam Vadnere, Vimal Sharma, and Md Usman. "Marrubium vulgare L.: A review on phytochemical and pharmacological aspects." Journal of Intercultural Ethnopharmacology 6, no. 4 (2017): 429. http://dx.doi.org/10.5455/jice.20170713060840.

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20

OKUR, Mehmet Evren, Nihal KARAKAŞ, Ayşe Esra KARADAĞ, Rabia YILMAZ, and Fatih DEMİRCİ. "In vitro cytotoxicity evaluation of Marrubium vulgare L. methanol extract." Journal of Research in Pharmacy 23, no. 4 (2019): 711–18. http://dx.doi.org/10.12991/jrp.2019.180.

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21

Weel, Koen G. C., Petras R. Venskutonis, Audrius Pukalskas, Dainora Gruzdiene, and Jozef P. H. Linssen. "Antioxidant activity of horehound (Marrubium vulgare L.) grown in Lithuania." Lipid - Fett 101, no. 10 (1999): 395–400. http://dx.doi.org/10.1002/(sici)1521-4133(199910)101:10<395::aid-lipi395>3.0.co;2-l.

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22

Dmitruk, M., and W. Haratym. "Morphological differentiation of non-glandular and glandular trichomes on Marrubium vulgare L." Modern Phytomorphology 6 (April 1, 2014): 85. https://doi.org/10.5281/zenodo.160450.

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Marrubium vulgare L., commonly known as a white horehound or common horehound, belongs to the plant family Lamiaceae. It is a perennial aromatic herb which grows naturally in Europe, Asia, and America. Since ancient Egypt, this species has been known as a remedy for upper respiratory tract ailments. Nowadays, horehound is used in herbal medicine for treatment of liver diseases, biliary tract disorders, and for increasing the appetite and supporting the function of the stomach. The main biologically active substances in M. vulgare organs are: marrubiin, tannins, essential oils, and ursolic acid. The paper presents micromorphological analyses of non-glandular and glandular trichomes of M. vulgare. The research material was sampled from the plant collection in the Botanical Garden of the Maria Curie-Sklodowska University in Lublin (51°14′ N, 22°34′ E). The above-ground parts of horehound were collected during the flowering period in July 2013. Using light microscopy (LM) and scanning electron microscopy (SEM), the types and sizes of trichomes from the stem, leaf, calyx, and corolla were investigated. The results of the microscopic observations show that the surfaces of M. vulgare vegetative and reproductive organs are densely clothed with glandular and non-glandular trichomes. The glandular trichomes are of two main types: peltate and capitate. Peltate trichomes consist of a short stalk cell and a large head with secretory cells arranged in a circle. The height of a mature trichome is about 31.33 μm and the diameter of the head is 31.47 μm. The substance produced by secretory cells passes through the apical walls and accumulates within a space between the cuticle and the cell wall layer. Capitate long trichomes with a basal cell, long stalk, neck cell, and a unicellular head are 36.65 μm long and the diameter of the head is about 15.6 μm. There are two types of short capitate trichomes: with a bicellular head and a unicellular stalk and with four-celled head and a unicellular stalk. The length of these trichomes is on average 26.32 μm and the diameter of the head is 20.32 μm. Moreover, we observed two types of non-glandular trichomes: multicellular uniserrate and multicellular branched. The length of the non-glandular trichomes is between 60.69 μm and 1130.3 μm.
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Guedri Mkaddem, Mounira, Ahlem Zrig, Mariem Ben Abdallah, et al. "Variation of the Chemical Composition of Essential Oils and Total Phenols Content in Natural Populations of Marrubium vulgare L." Plants 11, no. 5 (2022): 612. http://dx.doi.org/10.3390/plants11050612.

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Marrubium vulgare is a valuable source of natural bioactive molecules with high preventive and therapeutic effectiveness. Therefore, this study aimed to study the chemical polymorphism of natural populations of M. vulgare in Tunisia by quantitative chemical markers and the estimation of divergence between populations. Phytochemical analyses of the eight natural populations of Tunisian Marrubium vulgare prospected in different bioclimatic stages, revealed 42 compounds of essential oils representing 96.08% to 100% of the total oil. Hydrocarbon sesquiterpenes were the main fraction of all the populations studied and β-bisabolene was the major compound (from 30.11% to 71.35% of the total oil). The phytochemical investigation of the M. vulgare plant indicated the presence of essential oil with significant percentages of phenolic compounds. A significant quantitative and qualitative variation in the essential oils is detected for both major and minor compounds. The principal components analysis (PCA) performed in the single and combined traits provides a good distinction among populations, not according to their geographical and/or bioclimatic origins. Moreover, the phytochemical analysis of the leaves showed that the Tunisian populations, i.e., the populations of Kasserine, Kef, and Beja, were very rich in phenolic compounds (from 20.8 to 44.65 mg GAE/g DW). Flavonoids compounds were also the main class of total polyphenols present in all the tested populations (from 8.91 to 37.48 mg RE/g DW). The quantitative genetic diversity estimated by the population’s structure, based on PCA analysis, was an adaptation to the changes in the environmental conditions. Overall, our study indicated that natural populations of M. vulgare had different chemotypes of essential oils and they were rich in phenolic compounds, particularly flavonoids, which opens a new prospect for industrial use and differential exploitation of this species.
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Amnay, Abdellatif, and Taha Ouriagli. "Evaluation of the Antioxidant Activity of Saponins Extracts in Marrubium vulgare L." Current Developments in Nutrition 6, Supplement_1 (2022): 502. http://dx.doi.org/10.1093/cdn/nzac077.005.

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Abstract Objectives This study is interested in the evaluation of the antioxidant activity of the saponins extracted from the Marrubium Vulgare L. Methods The saponins extracted were evaluated with three different methods: maceration after dilapidation D, soxhlet apparatus S and maceration E. The antioxidant activity was carried out with two methods: Ferric reducing antioxidant power FRAP and Phosphomolybdene PPM. Results The three methods present a yield of total saponins equal to 9.85%, 6.12% and 2.84% for the S extract, E extract and D extract, respectively. The FRAP test showed a significant antioxidant activity. Especially in the E extract which occupies the first place with a value of 2220.8 AAE/1g MS, in comparison with the ascorbic acid of 1000.2 AAE/1g DM for the concentration of 0.5mg/ml. The PPM test showed that all the saponins extracts present a higher activity than ascorbic acid, notably of the E extract which occupies the first place with a value of 15,808.8 AAE/1g DM, comparison with the ascorbic acid of 1288.5 AAE/1g DM for the concentration of 0.1mg/ml. Conclusions This study showed the interest of the Marrubium vulgare L. as a potential source of new biologically natural substances. Funding Sources Faculty of Medicine and Pharmacy &amp; Faculty of Sciences and Technologies, University of Sidi Mohamed Ben Abdellah, Fez, Morocco.
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DEMİRÖZ AKBULUT, Tuğçe, and Şüra BAYKAN. "EGE BÖLGESİ’NDE YAYILIŞ GÖSTEREN MARRUBIUM L. TAKSONLARININ ANATOMİSİ VE MORFOLOJİSİ." Ankara Universitesi Eczacilik Fakultesi Dergisi 47, no. 1 (2022): 5. http://dx.doi.org/10.33483/jfpau.1143201.

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Amaç: Bu çalışmada, Ege Bölgesi’nde yayılış gösteren 4’ü endemik olmak üzere 9 Marrubium L. taksonunu ve aynı taksonun farklı populasyonlarını anatomik ve morfolojik karakterleri bakımından kıyaslanması amaçlanmıştır. Ayrıca, yurt dışında pek çok ilacın terkibine giren M. vulgare’nin ülkemizde yayılış gösteren populasyonlarının Avrupa Farmakopesi kriterlerine uygun olup olmadıklarını değerlendirmek hedeflenmiştir.&#x0D; Gereç ve Yöntem: Morfolojik incelemelerde Türkiye Florası tayin anahtarında yer alan önemli yapılar ve Avrupa Farmakopesi kriterleri göz önünde bulundurularak makroskobik yapılar incelenmiş ve kaliks yapıları görüntülenmiştir. Anatomik incelemeler için de yine Avrupa Famakopesi esas alınmıştır.&#x0D; Sonuç ve Tartışma: Tüm taksonlarda farklı tipte örtü ve salgı tüyleri ile stoma, iletim demeti ve kollenkima gibi anatomik yapılara rastlanmıştır. Marrubium parviflorum’un iki alttürü ile endemik taksonlar M. rotundifolium, M. globosum subsp. globosum ve M. bourgaei subsp. caricum’un Türkiye Florası tayin anahtarına göre teşhis ve taksonomileri yönünden karışıklıklar olduğu tespit edilmiştir. Ayrıca 9 farklı lokaliteden toplanan M. vulgare populasyonu içerisinde 8 örnek Avrupa Farmakopesi’ne uygun bulunmuştur.
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Salama, Maha M., Eman E. Taher, and Mohamed M. El-Bahy. "Molluscicidal and Mosquitocidal Activities of the Essential oils of Thymus capitatus Hoff. et Link. and Marrubium vulgare L." Revista do Instituto de Medicina Tropical de São Paulo 54, no. 5 (2012): 281–86. http://dx.doi.org/10.1590/s0036-46652012000500008.

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Steam distillation of essential oils of aerial parts of Thymus capitatus and Marrubium vulgare L. collected at North cost of Egypt yielded 0.5% and 0.2%, respectively. Results of Gas chromatography-mass spectrometry analyses of the two samples identified 96.27% and 90.19% of the total oil composition for T. capitatus and M. vulgare, respectively. The two oil samples appeared dominated by the oxygenated constituents (88.22% for T. capitatus and 57.50% for M. vulgare), composed of phenols, mainly carvacrol (32.98%) and thymol (32.82%) in essential oil of T. capitatus, and thymol (34.55%) in essential oil of M. vulgare. It was evaluated the molluscicidal activity of T. capitatus and M. vulgare essential oils on adult and eggs of Biomphalaria alexandrina as well as their mosquitocidal activity on Culex pipiens. The LC50 and LC90 of T. capitatus essential oil against adult snails was 200 and 400 ppm/3hrs, respectively, while for M. vulgare it was 50 and 100 ppm/3hrs, respectively. Moreover, M. vulgare showed LC100 ovicidal activity at 200 ppm/24 hrs while T. capitatus oil showed no ovicidal activity. It was verified mosquitocidal activity, with LC50 and LC90 of 100 and 200 ppm/12hrs respectively for larvae, and 200 and 400 ppm/12hrs respectively for pupae of C. pipiens.
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Abadi, Abderazak, and Aicha Hassani. "Essential Oil Composition and Antioxidant Activity of Marrubium vulgare L. Growing Wild in Eastern Algeria." International Letters of Chemistry, Physics and Astronomy 14 (September 2013): 17–24. http://dx.doi.org/10.18052/www.scipress.com/ilcpa.14.17.

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In previous work [1], the essential oil of the aerial parts of Marrubium vulgare L. obtained by hydrodistillation was analysed by gas chromatography coupled to mass spectrometry (GC-MS) in order to determine their chemical composition. Fifty (50) components in the oil of M. vulgare were identified. The results demonstrated that the major components of the essential oil were: 4,8,12,16-Tetramethyl heptadecan-4-olid (16.97 %), Germacrene D-4-ol (9.61 %), α- pinéne (9.37 %), Phytol (4.87 %), Dehydro-sabina ketone (4.12 %), Piperitone (3.27 %), δ-Cadinene (3.13 %), 1-Octen-3-ol (2.35 %) and Benzaldehyde (2.31 %). In this study, the antioxidant properties of essential oil were examined. The results showed that this oil can be considered an effective source of antioxidants of natural origin. This is the first report on chemical composition of M. vulgare essential oil cultivated in Algeria and the original study on the antioxidant activity of M. vulgare essential oil. The antioxidant activity was investigated with one method: 2,2-diphenyl-1-picrylhydrazyl (DPPH) radical scavenging method.
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28

Rezgui, Marwa, Mabrouk Basma, Nuno Neng, José Manuel Nogueira, Leila Bettaieb Ben-Kaab, and Maria Eduarda Machado Araújo. "Evaluation of Marrubium vulgare Growing Wild in Tunisia for Its Potential as a Dietary Supplement." Foods 10, no. 11 (2021): 2864. http://dx.doi.org/10.3390/foods10112864.

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Marrubium vulgare L., known as horehound, is a widespread and widely known plant that is used in beer breweries and also as a traditional remedy in Tunisia. In this study, methanolic extracts of plants harvested from five different locations were investigated for their antioxidant activities using three assays (ferric reducing power, radical scavenging activity, and β-carotene-linoleic acid bleaching assay) as well as the total phenolic content. The mineral composition of the plant was also investigated concerning the following elements: Fe, Mg, Ca, Cu, Zn, Mn, K, and three heavy metals, Ni, Pb, and Cd. Marrubiin, the major bioactive diterpenoid lactone, was quantified by NMR in the samples. The essential oils were obtained by hydrodistillation, and their radical scavenging activity was investigated. The toxicity of essential oils was evaluated against Artemia salina (the brine shrimp larva). The essential oil showed a weak radical scavenging activity and low toxicity. Data obtained from the five different locations showed that the antioxidant activity, as well as the total phenolic and marrubiin content, were strongly affected by the harvest sites. The metal content in the samples showed differences with the harvest location, but there was always a great abundance of calcium, magnesium, and potassium.
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Hachi, Mohamed, Mohamed Hamidi, Mostefa Touati, Yasmina Berrabah, and Ayoub Korichi. "Phytoremediation potential of spontaneous plant species in soils contaminated by hexavalent chromium in Djelfa city (Algeria)." Research Journal of Chemistry and Environment 26, no. 1 (2021): 66–74. http://dx.doi.org/10.25303/2601rjce6674.

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This study aims to quantify hexavalent chromium in wastewater, plants and topsoil in Djelfa city (South of Algeria) in order to better understand the bioaccumulation and phytoremediation potential of eight spontaneous plant species growing in a polluted environment, namely Sisymbrium Irio, Spinacia oleracea, Avena Sativa, Silybum Eburneum, Euphorbia Bupleuroides, Thapsia Garganica, Hertia Cheirifolia and Marrubium Vulgare. Wastewater, soil and spontaneous plant samples were collected near Djelfa’s Oued Mellah valley. Spectrophotometric measurements of hexavalent chromium concentration were used to determine pollution levels and to assess the accumulation potential of studied spontaneous plants. The results showed that in wastewater, soil and plant samples, Cr(VI) concentrations near the tannery upstream were 0.6 mg/L, 44 mg/kg and 6.2 mg/kg respectively. The most significant bioaccumulation potential was recorded with Thapsia Garganica while the highest translocation factor (TF) was found in Marrubium Vulgare. These species could be considered as a promising phytoremediation solution for chromium-polluted soils. According to plant sample enrichment factor (EF), the roots of almost all tested plants were found to be more effective to accumulate Cr(VI) than shoots.
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30

Ghedadba, Nabil, Leila Hambaba, Massoud Hachemi, et al. "Antihyperglycemic Potential of Methanolic Extracts from the Medicinal Plants: Marrubium deserti De Noé and Marrubium vulgare L." International Journal of Pharmacology 20, no. 2 (2024): 269–78. http://dx.doi.org/10.3923/ijp.2024.269.278.

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Benslama, Abderrahim, and Warda Nouiri. "Isolation, Characterization and Antibacterial Activity of Endophytic Fungi from Marrubium vulgare L." Turkish Journal of Agriculture - Food Science and Technology 10, no. 4 (2022): 766–70. http://dx.doi.org/10.24925/turjaf.v10i4.766-770.5178.

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The aim of this work is the isolation, identification and evaluation of the antibacterial activity of endophytic fungi from the Algerian medicinal plant Marrubium vulgare L. The isolation of endophytic fungi is carried out by the method of sterilization of surface to eliminate epiphytes then incubation of the fragments treated according to a precise protocol. The identification of the grown isolates allowed us to obtain three fungal strains belonging to three genera: Fusarium, Alternaria and Chaetomium, which are generally of the Deuteromycete phylum. The antibacterial capacity of the fungi was tested against five human pathogenic bacteruim using the agar-fungi disk diffusion method. With an inhibition zone (IZ) spanning from 7.5 to 25 mm, all isolated fungal strains showed antibacterial activity against at least one of the bacteria tested.. However, Fusarium sp has the highest antibacterial activity with an IZ of 19 and 24 mm against S. aureus and B. subtilis, respectively. Finally, our results clearly confirm that the medicinal plant M. vulgare L. presents a reservoir of endophytic fungi, which can be used in various fields, especially pharmaceutical fields.
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Zawiślak, Grażyna. "Comparison of chemical composition of the essential oil from Marrubium vulgare L. and M. incanum Desr. during the second year of cultivation." Acta Agrobotanica 68, no. 1 (2015): 59–62. http://dx.doi.org/10.5586/aa.2015.002.

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Horehound herb (&lt;em&gt;Marrubium vulgare&lt;/em&gt; L.) is harvested from plantations in Poland. In our country, there are also favorable conditions for &lt;em&gt;M. incanum&lt;/em&gt; Desr. growing. The aim of the study was to compare the chemical composition of essential oils from &lt;em&gt;M. vulgare&lt;/em&gt; L. and &lt;em&gt;M. incanum&lt;/em&gt; Desr. in the second year of cultivation. The study revealed the presence of 31 compounds in the essential oil from &lt;em&gt;M. vulgare&lt;/em&gt; L. and 24 compounds in the essential oil from &lt;em&gt;M. incanum&lt;/em&gt; Desr. Chromatographic analysis revealed that the main compounds in the essential oil of &lt;em&gt;M. vulgare&lt;/em&gt; L. from a two-year plantation were as follows: E-caryophyllene (34.51–36.78%), germacrene D (22.45–27.18%), bicyclogermacrene (9.54–11.12%), δ-amorphene (6.15–8.18%), and carvacrol (4.71–6.64%), whereas the following compounds prevailed in the oil from &lt;em&gt;M. incanum&lt;/em&gt; Desr.: germacrene D (28.75–32.14%), E-caryophyllene (23.18–29.57%), α-cadinol (13.59–20.84%), and carvacrol (2.08–7.47%).
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33

Ansari, S., H. Charehgani, and R. Ghaderi. "Resistance of ten common medicinal plants to the root-knot nematode Meloidogyne javanica." Hellenic Plant Protection Journal 12, no. 1 (2019): 6–11. http://dx.doi.org/10.2478/hppj-2019-0002.

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Summary A preliminary survey indicated that the root-knot nematode Meloidogyne javanica is widely distributed in the rhizosphere of medicinal plants in Boyer-Ahmad region (Iran). Host suitability of ten species of medicinal plants to M. javanica was examined in a pot experiment under controlled greenhouse conditions: alkakengy (Physalis alkekengi L.), chamomile (Matricaria chamomilla L.), English plantain (Plantago lanceolata L.), fennel (Foeniculum vulgare Mill.), garden anchusa (Anchusa italica Retz.), horehound (Marrubium vulgare L.), lovage (Levisticum officinale L.), sorrel (Rumex acetosella L.), thistle (Echinops adenocaulos Boiss.) and woundwort (Stachys pilifera Benth.). According to the scheme of Canto-Saenz, seven species, namely garden anchusa, fennel, horehound, alkakengy, English plantain, woundwort and sorrel can be considered susceptible hosts with gall index (GI) &gt; 2 and reproduction factor (RF) &gt; 1, and thistle, lovage and chamomile, can be considered as hyper-susceptible with GI &gt; 2 and RF ≤ 1.
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Abadi, Abderazak, and Aicha Hassani. "Chemical Composition of Marrubium Vulgare l. Essential Oil from Algeria." International Letters of Chemistry, Physics and Astronomy 13 (September 2013): 210–14. http://dx.doi.org/10.18052/www.scipress.com/ilcpa.13.210.

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The chemical constituants of the essential oil from aerial parts of Marrubium vulgare, collected in Algeria, were analyzed by GC and GC/MS. The oil yield of the dried plant aerial parts, obtained by hydrodistillation, was 0.04% (w/w). 50 compounds, accounting for 82.46% of the oil, were identified. The major constituants were: 4,8,12,16-Tetramethyl heptadecan-4-olid (16.97%), Germacrene D-4-ol (9.61%), α-pinéne (9.37%) Phytol (4.87%), Dehydro-sabina ketone (4.12 %), Piperitone (3.27%), δ – Cadinene (3.13%), 1-Octen-3-ol (2.35%) and Benzaldehyde (2.31%).
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35

Zatla, Amina Tabet, Imane Mami, Mohammed El Amine Dib, and Mohammed El Amine Sifi. "Efficacy of Essential Oil and Hydrosol Extract of Marrubium vulgare on Fungi Responsible for Apples Rot." Anti-Infective Agents 18, no. 3 (2020): 285–93. http://dx.doi.org/10.2174/2211352517666190618105332.

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Background: The microorganisms such as Penicillium expansum and Botrytis cinerea are wellknown pathogens in apples during postharvest. So, to protect apples from these pathogens, chemical control methods were exercised. Introduction: The main objective of this work was to study the chemical composition and the in-vitro and in-vivo antifungal properties of essential oil and hydrosol extract of Marrubium vulgare. Methods: In this work, the air-dried aerial parts of Marrubium vulgare were hydrodistilled in a Clevengertype apparatus. The essential oil and hydrosol extract isolated were analyzed using Gas Chromatography (GC) and Mass Spectrometry (GC/MS). The in-vitro antifungal activity of the both extracts was investigated against Botrytis cinerea, Penicillium expansum and Alternaria alternata fungi using radial growth technique. The effect of the essential oil and hydrosol extract on disease development of apple caused by Penicillium expansum in the in-vivo conditions was assessed. Results: The essential oil of Marrubium vulgare was characterized principally by E-β-caryophyllene (23.5%), E-β-farnesene (21%), α-humulene (14.8%), β-bisabolene (11.1%), caryophyllene oxide (6.8%) and phytol (3.1%). While, the methyl-eugenol (65.5%), α-Bisabolol (12.5%), linalool (6.5%) and caryophyllene oxide (6.2%) were the major compounds of hydrosol extract. The result of in-vitro antifungal activity of hydrosol extract showed an interesting antifungal inhibition against Botrytis cinerea, Penicillium expansum and Alternaria alternata with percentage inhibition ranging from 77% to 89% at low concentration of 0.15 mL/L. The essential oil was found to inhibit the growth of Penicillium expansum in a dose-dependent manner, with a percentage inhibition of 100% at 30 mL/L. Furthermore, essential oil and hydrosol extract have demonstrated promising in-vivo antifungal activity to control infection of apples by Penicillium expansum up to 25th day of storage, compared with the control. Conclusion: The preventive and protective effects of essential oil and hydrosol extract could be exploited as an ideal alternative to synthetic fungicides for using the protection of stored apples from fungal phytopathogens.
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36

Abadi, Abderazak, and Aicha Hassani. "Essential Oil Composition and Antioxidant Activity of <i>Marrubium vulgare</i> L. Growing Wild in Eastern Algeria." International Letters of Chemistry, Physics and Astronomy 14 (May 19, 2013): 17–24. http://dx.doi.org/10.56431/p-4r37h0.

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In previous work [1], the essential oil of the aerial parts of Marrubium vulgare L. obtained by hydrodistillation was analysed by gas chromatography coupled to mass spectrometry (GC-MS) in order to determine their chemical composition. Fifty (50) components in the oil of M. vulgare were identified. The results demonstrated that the major components of the essential oil were: 4,8,12,16-Tetramethyl heptadecan-4-olid (16.97 %), Germacrene D-4-ol (9.61 %), α- pinéne (9.37 %), Phytol (4.87 %), Dehydro-sabina ketone (4.12 %), Piperitone (3.27 %), δ-Cadinene (3.13 %), 1-Octen-3-ol (2.35 %) and Benzaldehyde (2.31 %). In this study, the antioxidant properties of essential oil were examined. The results showed that this oil can be considered an effective source of antioxidants of natural origin. This is the first report on chemical composition of M. vulgare essential oil cultivated in Algeria and the original study on the antioxidant activity of M. vulgare essential oil. The antioxidant activity was investigated with one method: 2,2-diphenyl-1-picrylhydrazyl (DPPH) radical scavenging method.
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37

Rezgui, Marwa, Nessrine Majdoub, Sofiene Ben-Kaab, et al. "How Salt Stress Represses the Biosynthesis of Marrubiin and Disturbs the Antioxidant Activity of Marrubium Vulgare L." Polish Journal of Environmental Studies 26, no. 1 (2017): 267–77. http://dx.doi.org/10.15244/pjoes/64792.

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38

Kebbi, Sara, Hamza Fadel, Jean-claude Chalchat, et al. "Chemical Composition of Algerian Thymus algeriensis Boiss. & Reut. and Marrubium vulgare L. (Lamiaceae) Essential Oils from the Aures Region." Acta Scientifica Naturalis 7, no. 2 (2020): 1–14. http://dx.doi.org/10.2478/asn-2020-0016.

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AbstractThis study was aimed to determine the chemical composition of essential oils obtained from aerial parts of Thymus algeriensis Boiss. &amp; Reut. and Marrubium vulgare L. collected in the Aures region of Algeria. Essential oils were extracted by steam distillation method and analyzed using GC-MS and GC-FID techniques. Thirty-five (35) and twenty-nine (29) components were identified respectively in T. algeriensis and M. vulgare essential oils to represent respectively 94.8% and 75.7% of the total oil composition. The main compounds of T. algeriensis oil were germacrene D (29.6%), β-caryophyllene (11.0%), E-β-farnesene (7.8%), bicyclogermacrene (4.4%) and δ-cadinene (4.0%), while, β-bisaboene (36.3%), β-caryophyllene (7.8%), phytol (6.2%), nonacosane (4.0%) and heptacosane (3.3%) were the main components of M. vulgare oil. The richness of these two oils in germacrene D and β-bisaboene respectively could suggest a new bioactivity.
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39

Amri, Bédis, Emanuela Martino, Francesca Vitulo, et al. "Marrubium vulgare L. Leave Extract: Phytochemical Composition, Antioxidant and Wound Healing Properties." Molecules 22, no. 11 (2017): 1851. http://dx.doi.org/10.3390/molecules22111851.

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40

Ouriagli, Taha, and Abdellatif Amnay. "Evaluation of Antioxidant Activity of Alkaloid Extracts Obtained From Marrubium vulgare L." Current Developments in Nutrition 6, Supplement_1 (2022): 526. http://dx.doi.org/10.1093/cdn/nzac077.029.

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Abstract Objectives The aim of the present study is the evaluation of the antioxidant activity of alkaloid extracts in Marrubium Vulgare L. Methods The extraction of total alkaloids was carried out by three different methods (Soxhlet, Maceration, and Reflux). The principle is based on the elimination of impurities contained in each phase (organic and aqueous), until obtaining a greenish-black pasty residue, presenting the total alkaloids. The antioxidant activity was determined by two methods; total antioxidant activity and ferric reducing antioxidant power. Ascorbic acid was used as a standard. Results The extraction by maceration and by Soxhlet present higher values (9.81% and 9.57% respectively), than the extraction by reflux which presented 6.73%. The Soxhlet extract presented the highest antioxidant activity around 62,500 AAE/1gDM, while the value of ascorbic acid was 26,137.76 AAE/1gDM. Similarly, the results were observed by the ferric reducing antioxidant power, the Soxhlet extract showed the highest activity around 862.48 AAE/1gDM, while the value of ascorbic acid was 733.74 AAE/1gDM. NB: AAE/1gDM = Ascorbic Acid Equivalent per one gram of Dry Matter. Conclusions The present results reveal that the Soxhlet extract represented a higher value regarding the yield and the antioxidant activity. Funding Sources Faculty of Medicine and Pharmacy &amp; Faculty of Sciences and Technologies, University Sidi Mohamed Ben Abdellah, Fez, Morocco.
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Rached, Sara, Hamada Imatara, Amar Habsaoui, et al. "Characterization, Chemical Compounds and Biological Activities of Marrubium vulgare L. Essential Oil." Processes 10, no. 10 (2022): 2110. http://dx.doi.org/10.3390/pr10102110.

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As consumer trends shift towards more natural and ecological consumption patterns, industrialists are actively working towards substituting synthetic chemicals with natural and vegan products that contain bioactive properties. Thus, considering the shifts in customer demand and the growing concern around vegetable sourced productions, this work aims to contribute to the valorization of aromatic and medicinal Moroccan plants. By focusing on the Marrubium vulgare L. species, our objective is to carry out a physicochemical characterization to determine its chemical composition and biological activities. The volatile fraction collected by hydrodistillation (0.61%) and analyzed by GC-MS (gas chromatography coupled to mass spectrometry) contains five main compounds: 3-Thujanone, Eugenol, Topanol, Menthone and Piperitone. The antioxidant activity has been estimated by applying the DPPH (1,1-diphenyl-2-picrylhydrazyl) free radical scavenging test and the ferric reducing antioxidant power (FRAP). The values of inhibitory concentration prove that our oil is a good antioxidant, with values of IC50 = 1.136 mg/mL and IC50 = 2.998 mg/mL, respectively, for the DPPH and FRAP tests. The results of the antifungal activity indicate a significant inhibition of mycelial growth for both tested molds, as well as a total inhibition of spore production at a concentration of 0.25 µL/mL.
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42

Nedjimi, Bouzid, Zahrat E. Souissi, Brahim Guit, and Youcef Daoud. "Differential effects of soluble salts on seed germination of Marrubium vulgare L." Journal of Applied Research on Medicinal and Aromatic Plants 17 (May 2020): 100250. http://dx.doi.org/10.1016/j.jarmap.2020.100250.

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43

Haratym, Weronika, and Elżbieta Weryszko-Chmielewska. "Ultrastructural and histochemical analysis of glandular trichomes of Marrubium vulgare L. (Lamiaceae)." Flora 231 (June 2017): 11–20. http://dx.doi.org/10.1016/j.flora.2017.04.001.

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44

Mssillou, Ibrahim, Abdelkrim Agour, Noureddine Hamamouch, Badiaa Lyoussi, and Elhoussine Derwich. "Chemical Composition and In Vitro Antioxidant and Antimicrobial Activities of Marrubium vulgare L." Scientific World Journal 2021 (October 31, 2021): 1–8. http://dx.doi.org/10.1155/2021/7011493.

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In this study, the polyphenol content and the antioxidant and antimicrobial activities of hydroethanolic (MVE) and hydroacetonic (MVA) leaf extracts of Marrubium vulgare L. were examined. The results indicated that the total phenolic content was higher in MVA (112.09 ± 4.77 mg GAE/DW) compared to MVE extract (98.77 ± 1.68 mg GAE/DW). The total flavonoid content was also higher in MVA extract (21.08 ± 0.38 mg QE/g DW) compared to MVE (17.65 ± 0.73 mg QE/g DW). Analysis of the chemical composition revealed the presence of 13 compounds with a total of 96.14%, with the major compound being malic acid (22.57%). Both extracts possess a good total antioxidant activity. DPPH and FRAP assays indicated that the MVE extract possesses a better antioxidant activity, with IC50 = 52.04 µg/mL ± 0.2 and EC50 of 4.51 ± 0.5 mg/mL, compared to MVA extract (IC50 = 60.57 ± 0.6 µg/mL and EC50 of 6.43 ± 0.0411 mg/mL). Moreover, both extracts exhibited strong antimicrobial activity against certain nosocomial strains as indicted by the MIC values, which ranged between 0.93 mg/mL and 10 mg/mL. Taken together, these results reveal the importance of M. vulgare as a natural antioxidant with important antimicrobial activity.
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45

Abadi, Abderazak, and Aicha Hassani. "Chemical Composition of Marrubium <i>Vulgare l</i>. Essential Oil from Algeria." International Letters of Chemistry, Physics and Astronomy 13 (May 3, 2013): 210–14. http://dx.doi.org/10.56431/p-5t09it.

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The chemical constituants of the essential oil from aerial parts of Marrubium vulgare, collected in Algeria, were analyzed by GC and GC/MS. The oil yield of the dried plant aerial parts, obtained by hydrodistillation, was 0.04% (w/w). 50 compounds, accounting for 82.46% of the oil, were identified. The major constituants were: 4,8,12,16-Tetramethyl heptadecan-4-olid (16.97%), Germacrene D-4-ol (9.61%), α-pinéne (9.37%) Phytol (4.87%), Dehydro-sabina ketone (4.12 %), Piperitone (3.27%), δ – Cadinene (3.13%), 1-Octen-3-ol (2.35%) and Benzaldehyde (2.31%).
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46

Amri, Bédis, Sofiene Ben Kaab, Houda Gouia, Emanuela Martino, Simona Collina, and Leila Bettaeib Ben Kaâb. "Copper-induced changes in nutrient uptake, enzymatic and non-enzymatic antioxidant systems in horehound (Marrubium vulgare L.)." Botanical Sciences 95, no. 3 (2017): 565. http://dx.doi.org/10.17129/botsci.778.

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&lt;p&gt;&lt;strong&gt;Background:&lt;/strong&gt; The effect of different concentrations (80, 200 and 300 mg/L) of copper (Cu&lt;sup&gt;2+&lt;/sup&gt;) on physiological parameters of horehound (&lt;em&gt;Marrubium vulgare&lt;/em&gt; L.) was studied. Once Horehound was cultivated in pots, element uptake and antioxidant system efficiency have been evaluated.&lt;/p&gt;&lt;p&gt;&lt;strong&gt;Questions:&lt;/strong&gt; What is the effect of copper on the physiological parameters of &lt;em&gt;Marrubium vulgare&lt;/em&gt;? What are the defense strategies developed by this plant to overcome cupric stress?&lt;/p&gt;&lt;p&gt;Species study: horehound (&lt;em&gt;M. vulgare&lt;/em&gt;) medicinal plant from the family of Lamiaceae.&lt;/p&gt;&lt;p&gt;Study site and dates: Seeds of &lt;em&gt;M. vulgare&lt;/em&gt; were issued from a non contaminated wild population in the region of Béja (Northwestern Tunisia). Culture of &lt;em&gt;M. vulgare&lt;/em&gt; was conducted in 1 August 2014 and lasted 4 months.&lt;/p&gt;&lt;p&gt;&lt;strong&gt;Methods:&lt;/strong&gt; The Cu, Fe, K, Mg and Ca contents have been determined. Total phenolic and flavonoid contents have been determined. The free radical scavenging activity (DPPH test) together with SOD, CAT and APX antioxidant enzymatic activity have been evaluated.&lt;/p&gt;&lt;p&gt;&lt;strong&gt;Results:&lt;/strong&gt; In the aerial part extracts, Copper stress reduced the uptake and translocation of the cationic elements Fe&lt;sup&gt;2+&lt;/sup&gt;, K&lt;sup&gt;+&lt;/sup&gt; and Ca&lt;sup&gt;2+&lt;/sup&gt;, in a Cu&lt;sup&gt;2+ &lt;/sup&gt;concentration-dependent manner. The treatment with copper gives rise to positive effects on antioxidant enzymes activities (SOD and CAT enzymes) and to an increase of total phenol and flavonoid contents. Unexpectedly, no correlation with the anti-radical scavenging activity was observed.&lt;/p&gt;&lt;p&gt;&lt;strong&gt;Conclusions:&lt;/strong&gt; &lt;em&gt;M. vulgare &lt;/em&gt;possess an intrinsic capability to cope with the Cu stress by activation of the enzymatic and non-enzymatic antioxidant systems.&lt;/p&gt;
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Emam, Mahmoud, Samah A. El-Newary, Hanan Y. Aati, Bin Wei, Mohamed Seif, and Abeer Y. Ibrahim. "Anti-Alzheimer’s Potency of Rich Phenylethanoid Glycosides Extract from Marrubium vulgare L.: In Vitro and In Silico Studies." Pharmaceuticals 17, no. 10 (2024): 1282. http://dx.doi.org/10.3390/ph17101282.

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Background/Objectives: Marrubium vulgare L. (M. vulgare), the white horehound, is well known for treating inflammation-related diseases. Methods: In this context, we investigated the efficacy of M. vulgare ingredients in treating Alzheimer’s disease using various in vitro and in silico antioxidant, anti-inflammatory, anti-cholinesterase, and anti-tyrosinase mechanisms. Results: In our results, sixty-one components were tentatively identified using gas and liquid chromatography (GC-MS and LC-MSn) and categorized as hydrocarbons, fatty acids, and polyphenolics. The extract inhibited linoleic oxidation with an IC50 value of 114.72 µg/mL, captured iron (Fe2+) ions with an IC50 value of 164.19 µg/mL, and displayed reducing power. In addition, the extract showed radical-scavenging ability towards DPPH•, NO•, ABTS•+, and H2O2 assays compared to L-ascorbic acid and butylated hydroxytoluene. The DPPH• was scavenged by 77.62% at 100 µg/mL, and NO•, ABTS•+, and H2O2 were scavenged with IC50 values of 531.66, 117.51, and 143.10 µg/mL, respectively. M. vulgare also exhibited discriminating anti-inflammatory potency against cyclooxygenase (COX-2) with IC50 values of 619.15 µg/mL compared to celecoxib (p &gt; 0.05). Notably, three Alzheimer’s biomarkers, acetylcholinesterase (AChE), butyrylcholinesterase (BChE), and tyrosinase were significantly inhibited. The molecular docking study supposed that the phenylethanoid glycosides of samioside and forsythoside B inhibited AChE and tyrosinase enzymes with low binding affinities of −9.969 and −8.804 kcal/mol, respectively. Marruboside was a proper inhibitor of COX and BChE enzymes with a binding score of −10.218 and −10.306 kcal/mol, respectively. Conclusions: M. vulgare extract showed significant inhibitory actions, which suggest that it could have a promising potential as an anti-Alzheimer agent.
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Ana, BÎRSAN, CRIVOI Aurelia, BACALOV Iurie, et al. "EFECTUL ANTIINFLAMATOR AL UNOR PLANTE DIN FLORA SPONTANĂ A REPUBLICII MOLDOVA UTILIZATE ÎN PREVENIREA ȘI TRATAMENTUL BOLILOR RESPIRATORII, ÎN CONTEXTUL COVID-19." STUDIA UNIVERSITATIS MOLDAVIAE Științe Reale și ale Naturii, no. 6(146) (2021): 3–16. https://doi.org/10.5281/zenodo.5678774.

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&Icirc;n baza temei tratate a fost selectată literatura de specialitate prezentă &icirc;n biblioteca USM și &icirc;n bazele de date NCBI, MedPUB, Google scholar. Sursele de specialitate au fost analizate pornind de la principalele plante medicinale utilizate &icirc;n tratamentul bolilor respiratorii: <em>Althaea officinalis</em>&nbsp;L.,<em> Hedera helix </em>L.,<em> Hippophae rhamnoides</em>&nbsp;L., <em>Inula helenium </em>L., <em>Malva sylvestris</em>&nbsp;L.,<em> Marrubium vulgare</em>&nbsp;L.,<em> Origanum vulgare </em>L<em>., Plantago major</em>&nbsp;L., <em>Primula veris</em>&nbsp;L.,<em> Sambucus nigra</em>&nbsp;L., <em>Silybum marianum</em>&nbsp;L., <em>Taraxacum officinale</em>&nbsp; <em>L., <em>Thymus vulgaris</em></em>&nbsp;L.,<em> Tussilago </em><em>farfara </em>L. Rezultatele studiului au permis identificarea plantelor medicinale cu activitate antiinflamatoare, care ar putea servi drept potențiale surse de profilaxie / tratament &icirc;n caz de Covid-19. Pentru toate plantele luate &icirc;n studiu au fost prezentate dovezi științifice cu referire la potențialul antiinflamator al acestora, ceea ce indică asupra posibilității de utilizare a acestor plante &icirc;n atenuarea simptomaticii &icirc;n Covid-19.
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Nabil, GHEDADBA, HAMBABA Leila, C. ABERKANE M., Oueld-Mokhtar M., FERCHA Nassima, and BOUSSELSELA Houas. "Évaluation de l'activité hémostatique in vitro de l'extrait aqueux des feuilles de Marrubium vulgare L." Algerian Journal of Natural Products 2, no. 2 (2014): 64–74. https://doi.org/10.5281/zenodo.556745.

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L'objectif de cette étude est d’évaluer <em>in vitro</em> l’activité hémostatique des métabolites secondaires des feuilles de <em>Marrubium vulgare</em>. L’analyse qualitative de l’extrait aqueux (EAQ) par la chromatographie sur couche mince a révélé la présence de la quercétine, la rutine et le kaempférol. La quantification des phénols totaux par la méthode de Folin Ciocalteu et des flavonoïdes par la méthode AlCl<sub>3</sub> a donné des valeurs élevées avec l’EAQ : 175 ± 0,80 mg EAG/100g de MS, 23,86 ± 0,36 mg EQ/100g de MS. De plus, le dosage des tanins condensés par la méthode de la vanilline a montré que l’EAQ contient la valeur la plus élevée : 16,55 ± 0,03 mg E-Catéchine/100g de MS. L’évaluation de l’activité hémostatique par la méthode de recalcification du plasma décalcifié nous a permis de découvrir l’effet anticoagulant de l’EAQ lyophilisé des feuilles de <em>M. vulgare</em>. Une corrélation linéaire positive entre les deux paramètres étudiés (la teneur en tanins condensés et l’activité hémostatique (r = 0,96)) ont permis de mettre en évidence un rôle probable de ces composés qui sont des vaso-constricteurs puissants dans l’activité hémostatique.
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Rezgui, M., N. Majdoub, B. Mabrouk, et al. "Antioxidant and antifungal activities of marrubiin, extracts and essential oil from Marrubium vulgare L. against pathogenic dermatophyte strains." Journal de Mycologie Médicale 30, no. 1 (2020): 100927. http://dx.doi.org/10.1016/j.mycmed.2020.100927.

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