Dissertations / Theses on the topic 'Mary's G.F.C'

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Fibrosis is a chronic liver disease that is a major cause of human mortality and is characterized by the accumulation of extracellular matrix in response to chronic liver injury. Important causes of chronic liver injury are: viral hepatitis, metabolic diseases, autoimmune diseases and exposure to chemicals, such as alcohol or drugs. The GRX cells are a representative line of hepatic stellate cells (HSC), which is associated with development of fibrosis, in the last stage is the cirrhosis. In healthy liver, these cells exhibit a phenotype or quiescent lipocyte characterized by its hability to store lipid droplets. Gallic acid is involved in several biological processes such as cell growth inhibition and apoptosis also has a variety of pharmacological actions, including antioxidant activity, anti-inflammatory, antimicrobial and antitumor. The aim of this study was to investigate the in vitro effects of gallic acid on the phenotype of HSC. The results showed that gallic acid is able to reduce cell proliferation, induce quiescent phenotype in HSCs by increasing lipid droplets, probably by activating peroxisome proliferator-activated receptor gama, decrease of transforming growth factor 1 signaling and decreased expression of collagen type I. These results demonstrate that the gallic acid may be a novel therapeutic agent for treating hepatic fibrosis.
A fibrose ? uma doen?a cr?nica do f?gado que representa uma das maiores causas de mortalidade humana e ? caracterizada pelo ac?mulo de matriz extracelular em resposta ? les?o hep?tica cr?nica. Importantes causas de les?es hep?ticas cr?nicas s?o: hepatites virais, doen?as metab?licas, doen?as autoimunes e exposi??o a subst?ncias qu?micas, como ?lcool ou drogas. As c?lulas GRX s?o uma linhagem representativa das c?lulas estreladas hep?ticas (HSC), que est? associada ao desenvolvimento da fibrose que, em ?ltimo est?gio, ? a cirrose. No f?gado saud?vel, estas c?lulas apresentam um fen?tipo quiescente ou lipoc?tico, caracterizado pela sua capacidade de armazenar got?culas lip?dicas. O ?cido g?lico est? envolvido em v?rios processos biol?gicos, tais como a inibi??o do crescimento celular e apoptose, al?m de possuir uma variedade de a??es farmacol?gicas, incluindo as atividades antioxidantes, anti-inflamat?rias, antimicrobiana e antitumoral. O objetivo deste estudo foi investigar os efeitos in vitro do ?cido g?lico sobre o fen?tipo das HSC. Os resultados obtidos mostraram que o ?cido g?lico ? capaz reduzir a prolifera??o celular, induzir o fen?tipo quiescente nas HSCs pelo aumento de got?culas lip?dicas, provavelmente pela ativa??o do receptor ativado por proliferador de peroxissomo gama, bloqueio da sinaliza??o de fator de transforma??o do crescimento beta 1 e diminui??o da express?o do col?geno tipo I. Estes resultados demonstram que o ?cido g?lico pode ser um novo agente terap?utico para o tratamento de fibrose hep?tica.

Thesis (Ph. D.)--Ohio State University, 2003.
Title from first page of PDF file. Document formatted into pages; contains xiii, 395 p.; also includes graphics Includes bibliographical references (p. 383-395). Available online via OhioLINK's ETD Center

This study investigates and documents tenor/bass trombone solo performances at the Gewandhaus, Leipzig, East Germany, between 1821 and 1876. Included is the discussion of a newly discovered composition, the Concertino fur Bassposaune und Orchester, by Carl Heinrlch Meyer, which is the earliest concerto for the tenor/bass trombone. Its performance at the Gewandhaus in 1821 marked the beginning of the solo tradition for the tenor/bass trombone, and the Leipzig Gewandhaus became one of the leading centers of solo trombone performance for the next fifty years. The study includes background information on the rise of the virtuoso soloist in nineteenth-century Germany. It specifically focuses on Friedrlch August Belcke and Carl Traugott Queisser and their performances at the Gewandhaus. All solo trombone performances at the Gewandhaus in the nineteenth century have been documented, and specific information has been provided regarding the soloists, dates of performances and repertoire performed on the concerts. The paper includes a discussion of performance reviews from the Allgemeine Musfkalische Zeitung. The conclusion discusses the importance of solo trombone performance at the Gewandhaus, and the reason for its sudden decline after 1876.

The English art song in the 20th-century presents a performance challenge unique in the solo song repertoire. Unlike the corresponding bodies of German Lied and French mélodie, which proceeded from a well-ingrained national tradition of music and poetry, the English art song had no such background. The many British composers who have contributed to the song literature of this century reflect varied backgrounds and influences. Lennox Berkeley combined his English heritage with the French background of his mother's family, largely self-taught musical skills and an innate sensitivity to poetry to become one of the most prominent song composers of this century. He trained with Nadia Boulanger, gaining exposure to the formal and melodic techniques of Faure and the neo-classicism of Stravinsky. Berkeley composed a total of seventy-eight solo songs. His acceptance and furtherance of a fundamentally traditional songmaker's craft place him more directly in the post-war line of succession of English song than Benjamin Britten, whose innovative musical techniques place him in the vanguard of new music.This document explores those aspects of Berkeley's life and work that contribute to his compositional choices. It provides an overview of all of Berkeley's known solo songs as well as a more detailed analysis of Five Songs (Walter de la Mare), Five Poems CW.H. Auden) and Another Spring. The paper illustrates the qualities of Berkeley's songs which justify his inclusion among the most successful art song composers of this century

Jules Massenet's mélodies feature a distinct vocal treatment regarding musical prosody through his eight song cycles, including Poëme d'Avril, Poëme Pastoral, Poëme du Souvenir, Poëme d'Amour, Poëme d'Hiver, Poëme d'un Soir, and Quelques Chansons Mauves, and a collection, Expressions Lyriques. These mélodies show the influence of the trend of salon music and the high-level poetry from the poetic movements of romanticism, Parnassianism, and symbolism. This study deals with Massenet's mélodies relating to the prosody idea, which is conspicuous in his vocal treatment. His melodic styles feature four distinct aspects of vocal treatment including lyrical, recitative or parlando, melodramatic, and déclamation rhythmée, and represent the idea of musical prosody of phonetic, syntactic, and semantic aspects. Massenet's other musical idioms such as harmony, form, and piano treatment, are also closely related to the prosody matter as a semantic aspect, reinforcing the poetic mood and content. In this study, each melodic style related to French versification is examined in detail. The musical analysis regarding the other musical idioms on selected examples presents the semantic feature of prosody idea. The brief review of French versification and opinions regarding the performance are included. Massenet's contribution to the genre of mélodie, with the prose melody and treatment of piano as an equal partner of voice line, is clearly demonstrated. With this contribution, Massenet should be recognized as the most influential composer to the climatic time of French mélodie led by Fauré, and Debussy, and Duparc.

Les ligands orthostériques transmettent un signal complexe aux cellules en se fixant à l'intérieur de la pochette de liaison de leur récepteur cible. Le changement conformationel qui en résulte modifie l'efficacité du récepteur à recruter et activer les seconds messagers en amont des voies de signalisation, soit les protéines G hétérotrimériques dans le cas des récepteurs couplés aux protéines G (GPCRs). Ces variations entraînent une vaste gamme de modifications dans le milieu intracellulaire. Par exemple, l'activation de la protéine G q provoque entre autres l'activation de la phospholipase C? (PLC? ), la production d'inositol 1,4,5-trisphosphate (1P3), puis l'activation des protéines kinases C (PKC). L'activation de la protéine G s , pour sa part, stimule l'activité de l'adénylate cyclase (AC), ce qui entraîne la production d'AMPc et l'activation de la protéine kinase A (PKA). Un ligand n'influence pas nécessairement deux voies de signalisation indépendantes de façon similaire, ce qui lui confère la propriété de sélectivité fonctionnelle. Dans ce travail, nous avons caractérisé le profil pharmacologique de ligands orthostériques du récepteur FP de la PGF2? à l'aide d'un clone HEK-293-SL exprimant le récepteur FP de façon stable. La mesure de la production d'IP3 a permis d'évaluer la voie de la PLC alors que la mesure de la production d'AMP c a permis d'évaluer la voie de l'AC. Pour chacune d'entre elles, le fluprostenol s'est comporté comme un agoniste complet moins puissant que l'agoniste naturel. Le composé synthétique Al-8810 s'est comporté comme un agoniste partiel de la voie de la PLC, alors qu'il s'est avéré être un antagoniste de la voie de l'AC. Ces résultats démontrent que l'activité d'un ligand vis-à-vis un récepteur dépend du groupe d'effecteurs observé, ce qui illustre le concept de sélectivité fonctionnelle des ligands. L'étude des composés allostériques THG113 et THG113.824 démontre que ces derniers n'influencent pas la signalisation déclenchée en aval du récepteur FP par son agoniste naturel. Ces résultats suggèrent qu'ils agiraient comme antagoniste des effets de la PGF 2? par un mécanisme indépendant du récepteur FP. [Symboles non conformes]

In mid-eighteenth-century France, a type of ensemble music was introduced for harpsichord and another instrument(s) in which the harpsichord part is completely written out, instead of a bass line with figures to be realized. Composers of this genre used the word "accompanied" in the tides or in the prefaces of their collections to describe the genre. This study examines the earliest examples of this genre, the works of seven composers, published in the 1740's, (Mondonville, Rameau, Boismoitier, Clement, Dupuits, Guillemain, and Luc Marchand), and compares the various styles of the written out parts, both harpsichord and additional instrument, to determine the nature of the word, "accompaniment."

Avec les récentes réformes, dont la loi Hôpital, Patient, Santé et Territoires (HPST) de Juin 2009, l’hôpital s’est transformé non seulement dans sa forme organisationnelle par la mise en oeuvre des pôles mais aussi dans son rapport à son environnement. Cette organisation polaire vise à rechercher une performance par une approche médico-économique. Ainsi les dispositifs de gestion ont été mis en place et cherchent à rendre compte de cette performance. Dans ce contexte, comment peuvent travailler des professionnels de champs aussi différents que celui de la gestion et celui du soin ? La gestion sous-entend une optimisation des moyens, alors que le service public défend en priorité des valeurs d’utilité sociale et d’attention aux usagers. Les acteurs du soin ont une forte identification professionnelle à cette mission d’utilité sociale. Dans ce travail, nous proposons d’identifier en quoi les décalages culturels au sein des pôles hospitaliers, participent à une perte de sens et de reconnaissance des agents à leur travail. Ces écarts culturels seront appréciés plus précisément au travers de l’appropriation des outils de gestion. Cette étude se base sur des entretiens réalisés au sein de différents hôpitaux (CHU et CH) et de secteur Médecine, Chirurgie, Obstétrique (MCO) et psychiatrie. Elle révèle lanécessité de pratiques managériales innovantes tournées notamment vers la gestion interculturelle afin que chaque acteur de ces nouvelles structures hospitalières se sente compris et intégré dans cette dynamique. L’étude proposée peut constituer un retour d’expérience intéressant pour mieux comprendre et améliorer l’utilisation des nouveaux outils de gestion. Des préconisations sont proposées et peuvent constituer des pistes de réflexion afin de répondre aux défis actuels de l’hôpital public
With the latest reforms, among which the Hospital, Patient, Healthcare and Territory (HPST) Law, the French Hospital has changed not only the form of its organisation through the implementation of a polar organisation, but also its environmental concern. This polar organisation aims to strive for performance and efficiency via an managerial and medical approach. Thus, some management tools have been set up aimed in particular at giving feedback on such performance. In this context, how can professionals from such distinct fields as management and healthcare work? Management implies the optimization of resources when the public sector above all upholds values of social usefulness and patient care. Healthcare actors feel very much involved in this mission of social usefulness. In this work we propose to identify how cultural gaps within hospital poles contribute to a loss of meaning and acknowledgment among healthcare agents. Those cultural gaps will be examined more particularly through management tool appropriation. This study relies on interviews conducted in various healthcare facilities (PCO and psychiatric hospitals of various capacities such as CHU and CH). It reveals the need for innovative managerial practices, especially designed for intercultural management, so that every actor of these new hospital facilities may feel that they are understood and integrated in this dynamic process. The proposed study can make up interesting feedback to better understand and improve the use of these new management tools. Recommendations are issued that can be food for thought to meet the current challenges of public hospitals

A osteoartrite (OA) é uma doença que afecta que afecta todos os mamíferos, com uma expressão clínica e económica muito importante. No cão, a sua fisiopatologia clínica, médica e terapêutica são muito semelhantes às do Homem, tornando esta espécie num modelo natural de excelência para o estudo da OA no Homem. Associando-se a doença predominantemente ao aparecimento de sinais e sintomas clínicos envolvendo a(s) articulação(ões) afetada(s), o uso de terapêuticas locais administradas por via intra-articular (IA), possibilitam reduzir a quantidade da substância activa a utilizar para obter o efeito médico desejado, assim como os potenciais efeitos sistémicos colaterais. Desde há muito tempo que o uso de corticosteróides e ácido hialurónico têm assumido um papel relevante na terapia IA da OA. Actualmente, terapias inovadoras como o uso de concentrados de plaquetas autologas ou de anabolizantes, como o Estanozolol, têm-se revelado promissoras no controlo local da doença. Contudo, os seus mecanismos de ação não estão ainda totalmente esclarecidos, o que se traduz na dificuldade em obter consenso entre os clínicos para o estabelecimento de protocolos padronizados, fazendo-se assim a sua utilização com base na medicina de evidência resultante da experiência individual do clínico. A monitorização da OA no que respeita à sua evolução e resposta à terapeutica instituída é actualmente monitorizada com o recurso a marcadores de inflamação, técnicas de imagem como a radiografia e termografia digitais, ao estudo e análise da biomecânica do doente em placas ou plataformas de força, que adicionam informação muito importante à colhida durante o exame clínico objectivo do doente. O presente estudo realizado na espécie Canis familiaris com OA na articulação coxofemoral apresenta como principais objetivos: 1) Determinar o efeito de quatro substâncias administradas por via IA no maneio da OA da anca; 2) Avaliar a variação na concentração dos marcadores inflamatórios Proteína C-Reativa (PCR) e Interleucina-1 (IL-1) no líquido sinovial de doentes com OA coxofemoral; 3) Avaliar a relação entre a medicina laboratorial, a medicina de imagem e o exame médico objectivo do doente; 4) Validar o uso da termografia digital e da plataforma de pressão na avaliação da OA; e 5) Delinear um protocolo terapêutico para os doentes com OA coxofemoral utilizando o cão como modelo animal, sob o conceito geral de - Uma Única Saúde (One Health). O estudo foi desenvolvido numa amostra de cem articulações coxo-femorais (N = 100), de doentes com OA de ocorrência natural. A amostra estudada foi dividida aleatoriamente em cinco (5) grupos cada um com vinte (20) articulações, de acordo com o tipo de terapêutica IA administrada. Assim, consideraram-se: grupo de controlo (GC, n=20), grupo de hexacetonido de triancinolona (THG, n=20), grupo de concentrado de plaquetas (Grupo PCG, n=20), grupo de estanozolol (SG, n=20) e o grupo de acido hialurónico - Hylan GF 20 (HG, n=20). Cada doente foi avaliado em nove (9) tempos diferentes ao longo do estudo: dia 0 (dia do tratamento) e dias 8, 15, 30, 60, 90, 120, 150 e 180 após tratamento. As avaliações de cada doente e articulação foram realizadas com a análise da biomecânica do doente em plataforma de força, goniometria da articulação (amplitude articular em flexão e extensão), perímetro da coxa, termografia digital, radiografia digital, análise do líquido sinovial e quatro instrumentos de metrologia clínica, nomeadamente: Escala Rápida de Avaliação de Dor Canina (Canine Brief Pain Inventory), Escala de Osteoartite Canina de Liverpool (Liverpool Osteoarthritis in Dogs), Índice Ortopedico Canino (Canine Orthopedic Index) e Escala Analógica Visual de Hudson (Hudson Visual Analogue Scale). O trabalho estatístico dos dados foi realizado com o programa IBM SPSS Statistics version 20. Foram realizados vários testes estatísticos, de acordo com a análise pretendida: teste t de amostras emparelhadas, ANOVA de medidas repetidas, com correcção Huynh-Feldt, ou o teste de Wilcoxon. O teste de Kaplan-Meier, comparado com o teste log-rank, e a regressão de Cox foram conduzidos para avaliar sobrevivência. Todos os resultados obtidos forma considerados como estatisticamente significativos para o valor de P<0,05. Os grupos PCG e HG foram aqueles que registaram melhorias mais significativas e duradouras, de acordo com os resultados da regressão de Cox para as diferentes avaliações realizadas. Considerando as avaliações objectivas, PCH e HG apresentaram uma melhora de 81% e 69%, e de 61% e 57% para os índices de simetria e diminuição de suporte de peso em estação, respetivamente. De acordo com os resultados obtidos, o uso de concentrado de plaquetas autologas e de ácido hialurónico de alta densidade parecem ser os tratamentos preferenciais para a melhoria das alterações registadas nos doentes com OA, melhorando a qualidade de vida dos doentes. Os resultados obtidos permitiram verificar também uma redução no nível da dor nos doentes do grupo THG, o que pode ser atribuído ao marcado efeito anti-inflamatório dos corticosteróides; Title: Evaluation of the efficacy of four intra-articular therapeutic protocols for the control and treatment of osteoarthritis in a Canis familiaris model. ABSTRACT: Osteoarthritis (OA) affects all mammals, being an important and costly disease. The pathologic process, clinical presentation, and response to treatment are very similar in humans and dogs, making the naturally occurring canine osteoarthritis model the closest to a gold standard for the study of human osteoarthritis. Since OA is mainly symptomatic in the affected joint while lacking obvious extra-articular manifestations, it is well suited to have a local therapy administered by intra-articular (IA) injection, reducing the total amount required to produce an effect as well as systemic adverse effects. There are several substances used in the IA management of OA, some used for a long time, like corticosteroids and hyaluronan, while others have gained more recent attention, as autologous platelets and stanozolol. In common, regardless of how long they have been used, their action mechanisms and effects are not fully known, as the protocol for their use is usually based on the clinician’s individual experience. Disease evolution and response to treatment can be monitored through inflammation markers, different clinical evaluation modalities, as digital thermography, digital radiography, or stance analysis, which all add relevant information to the clinical examination. This study set four goals: 1) to determine the effect of four IA substances in the management of hip OA; 2) assess variations in C-reactive protein and IL-1 in the synovial fluid of patients with OA; 3) evaluate the relationship between laboratory medicine, with imaging results and clinical assessment; 4) validate the use of digital thermography and weight bearing evaluation in OA assessement; and 5) to outline a treatment protocol for patients with OA, with the dog as an animal model, under the One Health concept. One hundred (N=100) hip joints were selected from patients with naturally occurring osteoarthritis and randomly assigned to five groups: control group (CG, n=20), triamcinolone hexacetonide group (THG, n=20), platelet concentrate group (PCG, n=20), stanozolol group (SG, n=20) and Hylan G-F 20 group (HG, n=20). Evaluations were conducted on days 0 (treatment day), 8, 15, 30, 60, 90, 120, 150, and 180 days post-treatment. They consisted of the evaluation of weight distribution, joint range of motion at flexion and extension, thigh girth, digital thermography, radiographic signs, synovial fluid analysis, and four clinical metrology instruments were collected: Canine Brief Pain Inventory, Liverpool Osteoarthritis in Dogs, Canine Orthopedic Index and the Hudson Visual Analogue Scale. All results were analyzed with IBM SPSS Statistics version 20. Several statiscal tests were conducted, according to the intended analysis: Paired Samples T-Test, Repeated Measures ANOVA, with a Huynh-Feldt correction, or Wilcoxon Signed Ranks Test. Kaplan-Meier estimators were conducted and compared with the log-rank test. Cox proportional hazard regression analysis was performed to determine treatment survival. A significance level of P<0.05 was set. PCG and HG registered longer lasting effects, and better improvements according to the Cox hazard regression with the different assessments made. Considering objective parameters, PCH patients showed a 69%-81% improvement in symmetry and weight-bearing reduction, respectively, while HG showed 61% and 57% improvements. These seem to be the preferred treatments for functional impairments due to OA. In addition to these evaluations, PCG and HG also registered more significant improvements in several scores as Hudson Visual Analogue Scale, stiffness, function, gait of the Canine Orthopedic Index. Better impact on pain interference was observed in THG, which could be attributed to the high anti-inflammatory effect of corticosteroids, and the relation between pain and inflammation.

Thesis (DPhil (History))--University of Stellenbosch, 2010.
ENGLSIH ABSTRACT: This study is a political biography of D.F. Malan (1874–1959), the first of the apartheid-era Prime Ministers, and covers the years 1874 to 1954, when Malan retired from politics. It endeavours to provide a warts-and-all account of D.F. Malan which challenges prevalent myths and stereotypes surrounding his public persona and his political orientation. While the overwhelming focus is on Malan’s political career, special attention is paid to his personal life in order to paint a multi-faceted picture of his character. The biography is written in the form of a seamless narrative and employs a literary style of writing. It is based on archival research which utilised Malan’s private collection, as well as the private collections of his Nationalist contemporaries. Malan takes the centre stage at all times, as the biography focuses on his perceptions and experiences. Malan’s views regarding Afrikaner nationalism, which was his foremost political priority, are described, and are related to his views of British imperialism as well as other ideologies such as communism and totalitarianism. This study demonstrates that there is a notable link between Malan’s perceptions of race relations and his concerns about the poor white problem. It reveals that Malan’s racial policy was, to some extent, fluid, as were his views on South Africa’s constitutional position. Debates about South Africa’s links to Britain and the nature of the envisioned republic preoccupied Afrikaner nationalists throughout the first half of the twentieth century – and served as an outlet for regional and generational tensions within the movement. Malan’s clashes with nationalists such as Tielman Roos, J.B.M. Hertzog and J.G. Strijdom are highlighted as an indication of the internecine power struggles within the National Party (NP). By emphasising these complexities, this study seeks to contribute to a nuanced understanding of the South African past.
AFRIKAANSE OPSOMMING: Hierdie studie is politieke biografie van D.F. Malan (1874–1959), die eerste van die apartheid-era Eerste Ministers, en dek die jare 1874 tot 1954, toe Malan uit die politiek getree het. Dit poog om onversuikerde beeld van Malan te skets wat heersende mites en stereotipes aangaande sy openbare beeld en sy benadering tot die politiek uitdaag. Die fokus is hoofsaaklik op Malan se politieke loopbaan, maar besondere aandag word aan sy private lewe geskenk om sodoende veelsydige portret van sy karakter te skilder. Die biografie is in die vorm van naatlose narratief geskryf en maak van literêre skryfstyl gebruik. Dit is gebaseer op argivale navorsing, waartydens daar van D.F. Malan se privaat versameling gebruik gemaak is, sowel as die privaat versamelings van sy tydgenote. Malan is ten alle tye die sentrale figuur en die biografie fokus op sy persepsies en ervarings. Malan se denke oor Afrikaner nasionalisme, wat sy vernaamste prioriteit was, word beskryf en in verband gebring met sy opinie van Britse imperialisme, sowel as ander ideologieë soos kommunisme en totalitarisme. Die studie wys op die verband tussen Malan se denke oor rasseverhoudinge en sy besorgdheid oor die armblanke vraagstuk. Dit dui daarop dat Malan se rassebeleid tot sekere mate vloeibaar was. Dit was ook die geval met sy benadering tot Suid-Afrika se konstitusionele posisie. Afrikaner nasionaliste het tydens die eerste helfte van die twintigste eeu baie aandag geskenk aan debatte oor Suid-Afrika se verhouding tot Brittanje en die aard van die voorgenome republiek. Dit was tot mate weerligafleier vir reeds bestaande spanning tussen die onderskeie streke en generasies. Malan se botsings met nasionaliste soos Tielman Roos, J.B.M. Hertzog en J.G. Strijdom word belig as aanduiding van die diepgewortelde magstryd binne die Nasionale Party (NP). Deur op hierdie kompleksiteite klem te lê, poog die studie om bydrae te lewer tot meer genuanseerde begrip van die Suid-Afrikaanse verlede.

碩士
雲林科技大學
休閒運動研究所碩士班
96
ABSTRACT T h e p u r p o s e o f t h i s s t u d y a r e : 1 . t o c omp a r e t h e d i f f e r e n c e s b e t we e n t h e d e e p l e i s u r e a t t r i b u t i o n a n d a f f lu e n t e x p e r i e n c e f r om t h e memb e r s o f t h e mu l t ip l e s t y l e swimmi n g p o o l o n u s i n g t h e v a r io u s f a c i l i t i e s , 2 . a n a l y z e t h e i n f l u e n c e s o n t h e d e e p l e i s u r e a t t r i b u t io n o f memb e r s f r om t h e a f f l u e n t e x p e r i e n c e s . T h e o b j e c t s o f t h e s t u d y we r e t a r g e t e d t o t h e memb e r s (N= 2 1 4 ) o f t h e To p i c a l F i s h Mu l t ip l e Swimmi n g P o o l i n Do u l i n , Yu n l i n c o u nt y, a n d u s in g T h e De e p Le i s u r e S c a l e a n d T h e a f f lu e n t E x p e r i e n c e S c a l e t o c o l l e c t t h e d a t a , a n d u s i n g t h e c lu s t e r a n a l y s i s 、t h e i n d e p e n d e n t s amp l e T- t e s t a n d s t e pwi s e r e g r e s s io n t o a n a l y z e t h e d a t a . T h e ma i n f i n d i n g s we r e : 1 . To d i v id e t h e c lu s t e r a n a l y s i s wh i c h a r e f r om t h e f i v e ma i n f a c i l i t i e s i n t h e mu l t ip l e s t y l e swimmi n g p o o l b y t h e memb e r s ’ f a v o r i t e s , t h e r e s u l t s a r e : t h e two g r o u p s o f t h e s t y l e o f wa t e r - p h i l i a a n d t h e t h e s t y l e o f s p o r t - p h i l i a . 2 . T h e r e wa s n o s ig n i f i c a n t d i f f e r e n c e o n t h e f o u r d oma i n s o f t h e d e e p l e i s u r e f r om t h e t h e s t y l e o f wa t e r - p h i l i a a n d t h e t h e s t y l e o f s p o r t - p h i l i a . 3 . T h e r e wa s s ig n i f i c a n t d i f f e r e n c e o n t h e a f f lu e n t e x p e r i e n c e s f r om t h e t h e s t y l e o f wa t e r - p h i l i a a n d t h e t h e s t y l e o f s p o r t - p h i l i a . 4 .T h e memb e r s ’ d e e p l e i s u r e a t t r i b u t i o n i s t h e p o s i t i v e p r e d i c t o f t h e a f f l u e n t e x p e r i e n c e s wh i c h p r e d i c t a b l e a b i l i t y i s 5 1 . 3 ~ 6 3 . 9 ％；t h e s e l f - h a r dwo r k i n g a t t r i b u t io n i s t h e ma i n p r e d i c t v a r i a b l e . T h e s t u d y e x p l a i n s o n t h e r e s u l t s , b e s id e s o f f e r i n g t h e a n a l y s i s a n d d i s c u s s o n t h e a p p l i c a t io n o f t h e r e s e a r c h r e s u l t s a n d p r o v id i n g s o me s u g g e s t io n f o r t h e l a t t e r r e s e a r c h . Ke

碩士
東海大學
音樂系
97
W. A. Mozart Sonata for Violin and Klavier in G minor, Op.1,No.10 W. A. Mozart Sonata for Klavier and Violin in C major, KV 296 J. Brahms：Sonata for Violin and Piano in A major, Op. 100 Pablo de Sarasate：Op. 23‚ No. 1 Playera ＆ No. 2 Zapateado

碩士
國立臺灣科技大學
營建工程系
93
This study proposes a measurement and assessment model for the construction productivity of freeway reconstruction project, according to on the previous studies of Thomas and the characteristics of the freeway reconstruction project. The model is used on the cases of the freeway No. 1 reconstruction projects and No. 2 new construction project in Taiwan to realize and compare their respective influence factors of the construction productivity. When the model evaluates the threshold construction productivity of the embankment in the cases, the estimate values for the reconstruction projects and the new construction project are 0.048~0.052 MH/ M 3 and 0.025 MH/ M 3 , respectively. In addition, the influence factors in the reconstruction projects and between the reconstruction projects and the new construction project are introduced, leading to the arrangement of improvement methods. The results based on this study can support the use of the model to various constructions to completely establish the threshold construction productivity in construction engineering for the further use of the cost analysis and construction management. The working content factor in the model, however, should be further studied in a future to obtain a better result.

A presente dissertação apresenta uma análise do mercado bolsista e pretende avaliar a sua integração para nove mercados da zona euro (Itália, França, Portugal, Espanha, Irlanda, Grécia, Finlândia, Bélgica e Áustria) utilizando como objeto de estudo os índices de preços bolsistas respeitantes a cada país. Todavia, atualmente, não existem muitos estudos que abordem esta temática somente ao nível das relações dos índices de preços bolsistas. Neste sentido, foi considerado fundamental analisar a estacionaridade destes índices, o que induziu à necessidade de utilizar modelos de cointegração. Testaram-se as relações de cointegração para os trinta e seis pares de mercados possíveis aplicando-se diferentes modelos e metodologias distintas. A análise desenvolvida apresenta como objetivo principal responder às perguntas de investigação formuladas. Deste modo, pretende-se averiguar se os índices bolsistas considerados estabelecem relações de cointegração entre si e aferir acerca do papel da crise económica que se fez sentir em relação à existência de quebras de estrutura. Concluiu-se com base nos resultados obtidos que as relações cointegrantes não foram consideravelmente afetadas por este evento. Os resultados alcançados através da combinação metodológica utilizada (testes de raiz unitária e testes de cointegração), revelam, de um modo geral que os pares de mercados em análise não se encontram cointegrados na sua totalidade, isto é, não apresentam entre si uma relação de cointegração forte. Contudo, foram detetadas situações de quebras estruturais ao nível dos índices bolsistas utilizados. As implicações práticas do estudo são também objeto de discussão.
The following dissertation presents an analysis of the stock market and pretends to evaluate its integration into nine markets in the eurozone (Italy, France, Portugal, Spain, Ireland, Greece, Finland, Belgium and Austria) using the indexes of stock prices for each country an object of study. However, currently, there are not many studies that approach this topic just at the level of stock price indexes. From this perception, it was considered essential to analyze the stationarity of these indexes, which led to the need to use cointegration models. The cointegration relationships were tested for the thirty-six pairs of possible markets by applying different models and different methodologies. The main objective of this analysis is to answer the initial research questions. In this way, it was tried to ascertain if the stock indexes considered establish relations of cointegration among themselves and to gauge the impact of the economic crisis that was felt in relation to the existence of structural breaks. It was concluded, from the results obtained, that the cointegrating relationships were not considerably affected by this event. The results achieved through the methodological combination used (unit root tests and cointegration tests), reveal, in general, that the pairs of markets under analysis are not cointegrated in their entireness, that is, they do not have a relation of cointegration. However, situations of structural breaks were detected at the level of stock indexes used. The practical implications of the study are also subject of discussion.

Este trabalho tem como objetivo determinar de forma empírica, como é que os determinantes macroeconómicos influenciam o índice acionista do PSI-20. Esta análise econométrica de séries temporais é feita para o período compreendido entre o primeiro trimestre de 2000 e o último trimestre de 2017. Considerando a literatura existente, foi estimada uma equação para o índice PSI-20 usando o método econométrico ARDL. Esta estimação utiliza oito variáveis independentes (PIB real, oferta monetária, brent, dívida pública, Eurostoxx 50, taxa de inflação, taxa de câmbio efetiva e taxa de juro). Os resultados indicam que o agregado monetário M3, o Eurostoxx 50, a taxa de inflação e a taxa de câmbio efetiva têm um efeito positivo no índice PSI-20. As variáveis PIB, brent e taxa de juro das OT’s a 10 anos exercem um efeito negativo no respetivo índice. A dívida pública não exerce qualquer efeito no índice.
This work aims to analyze, from an empirical point of view, how macroeconomic determinants influence the evolution of stock market index of PSI-20. This time series econometric analysis is performed for the period from the first quarter of 2000 and the last quarter of 2017. Taking into account the existing literature, we estimate an equation for the stock market index of PSI-20 using the ARDL econometric model. This estimation uses eight independent variables (real GDP, money supply, oil prices, public debt, Eurostoxx 50, inflation rate, effective exchange rate and interest rate). We conclude that money supply, Eurostoxx 50, inflation rate and effective exchange rate exert a positive impact on stock market index of PSI-20. GDP, oil prices and interest rate impact negatively in the respective stock market index. Public debt does not exert any effect on PSI-20.

O pr e s ent e r e l a tó r i o é d e s e nv ol vid o no âmbi t o de um Es t á gio Cu r r i c ul a r , com o ob j e c t i vo d e co n c lu s ã o do Me s t r a do em ge s t ão no In s t i tut o Sup e r i or d e Ge s t ão d e Li s bo a . Es t e t ev e a dur a ç ã o de 3 me s e s e t ev e como o r ga ni z a ç ã o r e c epto r a a In s t i tui ç ã o Di a n ov a . O e s t á gio é o po nto d e p a r t i d a p a r a a e nt r a d a no mun do l ab o r a l , a s u a r e a l i z a ç ão t e ve como pr in c i p a i s obj e c t iv os a ap l i c a ç ão de c o nh e c iment o e d a s c omp e t ên c i a s ad qui r i d a s no d e co r r e r do p e r cu r so a c a d émi co e a ob t en ç ã o d e no v a s c omp e t ên c i a s e n ov os mé t od os d e t r ab a lh o p a r a uma me l ho r e ma i s f á c i l a da pt a ç ão a o me r c ad o de t r ab a lh o. De s t a fo rma , o e s t á gio p e rmi t e e s t a r em c ont a c t o di r e c to c om a r e a l id a d e emp r e s a r i a l , o r ga n i z a c io n a l p os s i bi l i t a ndo o c o n f ro nto en t r e o s e n s i nament os t e ór i c o s e a su a apl i c a ç ã o p r á t i c a , c om o ob j e c t i vo d e f a c i l i t a r uma f utu r a i nt e gr a ç ã o n o mund o l a bo r a l . Es t e e s t á gi o t e ve c omo obj e c t iv o d a r a p oio di r e c t o à ge s t or a d e p r oj e c t os d a i ns t i tui ç ã o uma v e z qu e e s t e d e p a r t amen to e s t av a c om c a r ê n c i a d e t r ab a l ha d o r e s . Vi s a a i nd a a p r e s e nt a r a i n s t i t ui ç ã o onde d e c o r r e u o e s t á gio c u r r i cul a r , bem como a l guma s á r e a s e s e rv i ços p r a t i c ad a s p e l a me sma .

In this dissertation, we build different models to investigate contagion of currency, banking and sovereign debt crises across neighbor countries and trade partners by using Binary Logit Panel Data. Our analyses cover the periods 1970 – 2018 and 1800 – 2018 for more than 60 countries all around the world and specific control variables that are chosen according to the nature of each crisis. We have found that during the period of 1970 – 2018 contagion of currency crises has the lowest impact (average 63.5%) on the probability of currency crises happening in a country, while contagion of sovereign debt crises has the highest impact (average 187.5%) on the probability of sovereign debt crises happening in a country considering both results regarding neighbors and trade partners. On a regional basis, our results have shown that countries in Africa are only affected by the contagion of currency crises from their neighbor countries; in Europe, countries are affected by the contagion of currency and banking crises across both neighbors and trade partners; and in America, countries are also affected by the contagion of all 3 crises across their neighbors but they are not affected by the contagion of banking crises across their trade partners. Regarding different income levels our results have shown that low income level countries are not affected by contagion of any type of crises; while lower-middle income level countries are affected by all types of contagion of financial crises.
Nesta dissertação construimos diferentes modelos com o intuito de investigar o contágio das crises monetária, bancária e de divída soberana entre países vizinhos e parceiros comerciais, usando modelos logísticos binários para dados em painel. A nossa análise cobre os períodos 1970 – 2018 e 1800 – 2018 para mais de 60 países do mundo e variáveis de controlo específicas, que são escolhidas de acordo com a natureza da crise. Concluímos que durante o período de 1970 – 2018 o contágio em crises monetárias teve o menor impacto (média de 63,5%) na probabilidade de ocorrer num país, enquanto que em crises de divída soberana teve o maior impacto (média de 187,5%) na probabilidade de ocorrer, ambos considerando países vizinhos ou parceiros comerciais. A nível regional, os resultados mostram que os países em Africa são apenas afectados pelo contágio em crises monetárias de países vizinhos; na Europa pelo contágio das crises monetárias e bancárias entre países vizinhos ou parceiros comerciais; e na America pelo contágio das três crises entre países vizinhos, mas não são pelo contágio das crises bancárias entre países parceiros comerciais. Relativamente a diferentes níveis de rendimento, os resultados mostram que países de baixo rendimento não são afectados pelo contágio de qualquer crise, enquanto que os de médio rendimento são afectados pelo contágio de todas as crises financeiras.