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Dissertations / Theses on the topic 'Mass and Energy spectrometry'

Author: Grafiati

Published: 7 July 2024

Last updated: 31 July 2025

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1

Tsutsui, Yuko. "EXPLORING FUNCTIONAL AND FOLDING ENERGY LANDSCAPES BY HYDROGEN-DEUTERIUM EXCHANGE MASS SPECTROMETRY." Case Western Reserve University School of Graduate Studies / OhioLINK, 2008. http://rave.ohiolink.edu/etdc/view?acc_num=case1196199391.

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2

Fu, Tingting. "3D and High Sensitivity Micrometric Mass Spectrometry Imaging." Thesis, Université Paris-Saclay (ComUE), 2017. http://www.theses.fr/2017SACLS218/document.

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L'imagerie par spectrométrie de masse est d’un grand intérêt pour aborder les questions biologiques en fournissant simultanément des informations chimiques et spatiales. En particulier, la spectrométrie de masse baptisée TOF-SIMS est bien reconnue par sa haute résolution spatiale (< 1 μm), qui est essentielle pour révéler l'information chimique dans une zone submicronique. L'emploi croissant de cette technique dans la caractérisation des échantillons biologiques a bénéficié du développement de nouvelles sources d'ions d’agrégats. Cependant, les processus d'ionisation/désorption des analytes

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3

Rowland, Tyson G. "Accurate ionic bond energy measurements with TCID mass spectrometry and imaging PEPICO spectroscopy." Scholarly Commons, 2012. https://scholarlycommons.pacific.edu/uop_etds/809.

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Two projects are presented here. In the first, metal-cyclopentadienyl bond dissociation energies (BDEs) were measured for seven metallocene ions (Cp2M+, Cp = η5-cyclopentadienyl = c-C5H5, M = Ti, V, Cr, Mn, Fe, Co, Ni) using threshold collision-induced dissociation (TCID) performed in a guided ion beam tandem mass spectrometer. For all seven room temperature metallocene ions, the dominant dissociation pathway was simple Cp loss from the metal. Traces of other fragment ions were also detected, such as C10H10+, C10H8+, C8H8+, C3H3+, H2M+, C3H3M+, C6H6M+, and C7H6M+, depending on the metal center

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4

Begley, Ian S. "A study of isotope ratio measurement by inductively coupled plasma mass spectrometry." Thesis, Loughborough University, 1996. https://dspace.lboro.ac.uk/2134/12223.

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The measurement of isotopic ratios by inductively coupled plasma mass spectrometry (ICP-MS) has the benefits of ionising all metallic elements, simplifying sample preparation and reducing analysis time, when compared with thermal ionisation mass spectrometry (TIMS). However, the use of ICP-MS in isotopic ratio studies has been somewhat restricted by Its failure to offer the precision and accuracy required by a variety of applications. The precision achievable by ICPMS, typically 0.2 to 0.3 % RSD, for isotopic ratios, has generally been regarded as being primarily limited by instrumental instab

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5

Sassin, Nicholas A. "Optical and collisional energy transfer processes in fluorescent dyes, quaternary alkylammonium and peptide cations." abstract and full text PDF (free order & download UNR users only), 2008. http://0-gateway.proquest.com.innopac.library.unr.edu/openurl?url_ver=Z39.88-2004&rft_val_fmt=info:ofi/fmt:kev:mtx:dissertation&res_dat=xri:pqdiss&rft_dat=xri:pqdiss:3307572.

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6

Smith, Lori Lyn. "Effectiveness of low energy collisional activation methods for automated peptide sequencing by tandem mass spectrometry." Diss., The University of Arizona, 2003. http://hdl.handle.net/10150/280450.

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The relative efficiencies of low energy (< 100 eV) collisional activation techniques were determined for peptide sequencing by tandem mass spectrometry (MS/MS). Tryptic peptides were fragmented using either collision induced dissociation (CID) or surface induced dissociation (SID) to generate spectral databases. Statistical analysis of the resulting fragment ions and success rates for automated peptide sequencing by publicly available algorithms provided a measure of the value of sequencing information content of CID and SID MS/MS spectra. Typical success rates were determined for automated se

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7

Yau, Pui Yip. "Thresholds for production of gaseous ions in matrix-assisted laser desorption/ionisation mass spectrometry of bio-molecules." Thesis, University of Warwick, 1994. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.389459.

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8

Yang, Zhongyu. "Performance Advantages of Maximum Likelihood Methods in PRBS-Modulated Time-of-flight Energy Loss Spectroscopy." Fogler Library, University of Maine, 2003. http://www.library.umaine.edu/theses/pdf/YangZ2003.pdf.

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9

Bottrill, Andrew R. "High-energy collision-induced dissociation of macromolecules using tandem double-focusing/time-of-flight mass spectrometry." Thesis, University of Warwick, 2000. http://wrap.warwick.ac.uk/52318/.

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The first part of this study involves the adaptation of a matrix-assisted laser desorption/ionisation (MALDI) ion source for a tandem double-focusingltime-offlight instrument (MAG-TOF). Ion trajectory modelling was carried out for defining the optimum ion optical configuration for a new extraction region and associated ion optics that were designed and constructed. Installation of the new ion source resulted in increased sensitivity and no loss of resolution. The second part of this study involves the analysis of fullerenes and fullerene derivatives by high-energy collision-induced dissociatio

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10

Williams, Jonathan Paul. "Ion structure determination using novel time-of-flight techniques and mass-analysed ion kinetic energy spectrometry." Thesis, Swansea University, 2000. https://cronfa.swan.ac.uk/Record/cronfa42653.

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Mass spectrometry is a powerful analytical technique that possesses the capability of molecular characterisation of complex mixtures. The technique has been the method afforded in this study for the characterisation of such mixtures of industrial relevance. The last decade has seen an important revival of one area in particular, time-of-flight mass spectrometry, which has had a significant impact on the field of mass spectrometry. This has been largely due to two recently developed ionisation methods, namely electrospray and matrix-assisted laser desorption ionisation. These ionisation methods

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11

Saraswat, Suraj. "Investigation of Energy Transfer, Quantification, and Localization of Peptides and Proteins by Fluorescence Spectroscopy and Mass Spectrometry." University of Toledo / OhioLINK, 2012. http://rave.ohiolink.edu/etdc/view?acc_num=toledo1341599821.

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12

Treufeld, Imre. "I. Polymer Films for High Temperature Capacitor ApplicationsII. Differential Electrochemical Mass Spectrometry." Case Western Reserve University School of Graduate Studies / OhioLINK, 2016. http://rave.ohiolink.edu/etdc/view?acc_num=case1465503063.

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13

Angelico, Vincent James. "The development of a mass spectrometry-based technique that uses low energy ion-surface collisions to characterize surfaces." Diss., The University of Arizona, 2002. http://hdl.handle.net/10150/280148.

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Low energy (tens of eV) ion-surface collisions carried out in a tandem mass spectrometer are investigated as a tool to characterize self-assembled monolayer (SAM) films. The target films are prepared by spontaneous chemisorption of thiol-based (HS-R) compounds onto Au (111) substrates. Most of the films used as targets contain alkane or fluoro-alkane backbones, some with unique groups in the terminal position (e.g., -CD₃, -OH, -OC(O)CF₃). Pyrazine is the most frequently used probe ion, however in certain cases other small organic molecules are also used. Common interactions between the impingi

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14

Al-Qahtani, Khalid Mohammad. "Developing liquid chromatography-mass spectrometry strategies for investigating energy metabolism with application to isocitrate dehydrogenase mutations in cancer : development and application of methods for qualitative and quantitative analysis of TCA cycle metabolites using liquid chromatography coupled to mass spectrometry." Thesis, University of Oxford, 2015. https://ora.ox.ac.uk/objects/uuid:354009b1-30a5-43a0-bbf1-5907437ea53a.

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Isocitrate dehydrogenases (IDHs) act in the tricarboxylic acid (TCA) cycle to catalyse the conversion of isocitrate to 2-oxoglutarate (2-OG) with concomitant production of NADH and/or NADPH. In humans, mutations causing IDH1 and IDH2 substitutions have been found during DNA sequencing of human glioblastomas. Some cancerassociated IDH mutations promote the reduction of 2-OG to give D-2-hydroxyglutarate (D-2-HG) a chiral, polar dicarboxylic acid. Investigations on the underlying links between 2-HG and cancer require sensitive methods for monitoring IDH1 and IDH2 activities. The reported LC/MS me

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15

Yang, Xi. "Characterization of Self-Assembled Monolayers by Low Energy Reactive Ion Scattering: Influences of Terminal Group Composition and Structure on Ion-Surface Interaction." Diss., The University of Arizona, 2006. http://hdl.handle.net/10150/195240.

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Low energy (tens of eV) polyatomic cations were used as probes for characterization of monolayers of spontaneously chemisorbed thiols on gold. Characteristics including chemical composition, surface order and orientation of the self-assembled monolayers (SAMs) can be derived by monitoring the products of projectile ion neutralization, surface-induced dissociation (SID), and ion-surface reactions.To study the influence of the terminal group chemical structures and orientations of the SAMs on ion-surface interactions, a series of semi-fluorinated alkane thiols with difluoromethylenes buried unde

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16

Naylor, J. C. "The study of sputtering by concentration modulated absorption spectroscopy and the study of internal energy effects on collision induced decomposition mass spectrometry." Thesis, Swansea University, 1999. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.638299.

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The measurement of the absolute concentration of sputtered neutrals from a metal Li surface and polycrystalline NaC1 target has been achieved using the technique of concentration modulated absorption spectroscopy. The dependence of the amount sputtered on the target temperature, ion energy and target density has been investigated. The atomic density of the plume has been mapped in two dimensions under varying sputtering conditions. Utilising a previous theory describing a radial sputter distribution function the experiments have yielded values for the sputter yield of lithium and sodium. The p

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17

Zhang, Yifan. "Metabolic Energy Balances in Ketotic Rat Brain." Case Western Reserve University School of Graduate Studies / OhioLINK, 2013. http://rave.ohiolink.edu/etdc/view?acc_num=case1370371336.

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18

Mahdi, A. M. "A mass spectrometric study of translational energy release in the reactions of gas phase cations." Thesis, University of Essex, 1987. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.379376.

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19

Hennemann, Bruno Luís. "Energia de interação cátion-ânion de líquidos iônicos dicatiônicos em fase gasosa." Universidade Federal de Santa Maria, 2016. http://repositorio.ufsm.br/handle/1/11976.

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Electrospray ionization mass spectrometry (ESI-MS) with induced collision energy was used to carry out a comprehensive study on the interaction energies between cations and anions of dicationic ionic liquids. The influence of the anion ([Br]-, [NO3]-, [BF4]-, [SCN]- and [Cl]-) and the size of alkyl chain (n = 4,6,8 and 10) in the interaction energy of ionic liquids derived from the 1, n-bis (3-methylimidazolyl-1-yl) alkane with n = 4,6,8 and 10, in the gas phase was investigated. Three experiments were carried out to determine the cation-anion interaction energy: (i) ESI-MS of binary (1:1) mix

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20

Wishart, Cornelia. "Measurement of total body water (TBW) and total energy expenditure (TEE) using stable isotopes." Thesis, Queensland University of Technology, 2011. https://eprints.qut.edu.au/44135/1/Cornelia_Wishart_Thesis.pdf.

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Understanding the relationship between diet, physical activity and health in humans requires accurate measurement of body composition and daily energy expenditure. Stable isotopes provide a means of measuring total body water and daily energy expenditure under free-living conditions. While the use of isotope ratio mass spectrometry (IRMS) for the analysis of 2H (Deuterium) and 18O (Oxygen-18) is well established in the field of human energy metabolism research, numerous questions remain regarding the factors which influence analytical and measurement error using this methodology. This thesis

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21

Solders, Andreas. "Precision mass measurements : Final limit of SMILETRAP I and the developments of SMILETRAP II." Doctoral thesis, Stockholms universitet, Fysikum, 2011. http://urn.kb.se/resolve?urn=urn:nbn:se:su:diva-56777.

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The subject of this thesis is high-precision mass-measurements performed with Penning trap mass spectrometers (PTMS). In particular it describes the SMILETRAP I PTMS and the final results obtained with it, the masses of 40Ca and that of the proton. The mass of 40Ca is an indispensible input in the evaluation of measurements of the bound electron g-factor, used to test quantum electrodynamical calculations in strong fields. The value obtained agrees with available literature values but has a ten times higher precision. The measurement of the proton mass, considered a fundamental physical consta

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22

Al, Mahmoud Alsheikh Amer. "Modelování chemických procesů." Doctoral thesis, Vysoké učení technické v Brně. Fakulta chemická, 2015. http://www.nusl.cz/ntk/nusl-233403.

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V této práci je prezentována studie fragmentačního procesu zvolené molekuly a jeho vztah ke složení fragmentačních produktů. Práce je zaměřená na výpočet fragmentační energie molekuly pomocí ab initio kvantově chemických metod, metodou „density functional theory (DFT)“ a také srovnáním s experimentem. Je prezentován vliv výpočetní metody, bázového setu, a geometrie molekuly na simulaci. Byla porovnána fragmentace methylfenylsilanu (MPS), dimethylfenylsilanu (DMPS), a trimetylfenylsilanu (TMPS). Fragmentace byla iniciována monochromatickým elektronovým svazkem (EII). Hmotnostní spektrometrie by

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23

Steichen, Valentin. "Développement d’un analyseur en énergie pour la caractérisation des hautes atmosphères neutres et ionisées terrestre et planétaires." Electronic Thesis or Diss., Sorbonne université, 2023. http://www.theses.fr/2023SORUS635.

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L'étude de la dynamique des particules dans la thermosphère - ionosphère et dans l'exosphère des corps du système solaire permet d'approfondir notre compréhension de ces régions critiques qui sont l’interface entre une planète et l'espace. Le but de ma thèse était de développer, construire et tester un analyseur en énergie pour l'étude des hautes atmosphères planétaires : INEA (Ion and Neutral Energy Analyser). L'instrument vise à mesurer la structure énergétique des constituants neutres et ioniques présents dans cette région. Pour réaliser cette tâche difficile, INEA s'appuie sur deux concept

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24

Launay, Kévin. "Synthèse de nouveaux espaceurs alcoxyamine pour la préparation de polymères encodés." Electronic Thesis or Diss., Aix-Marseille, 2020. http://www.theses.fr/2020AIXM0487.

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Le monde numérique est en croissance permanente, ce qui nécessite de plus en plus d’espace de stockage. Cependant, les données numériques sont stockées sur des supports dont la durée de vie n’excède généralement pas quelques dizaines d’années. Ainsi, certaines entreprises leaders du monde numérique comme Microsoft, ont engagé des efforts dans la production de systèmes de stockage basés sur de l’ADN. Ce polymère souffre cependant d’un désavantage majeur : sa structure est fixée par la biologie. A l’inverse, la structure de polymères synthétiques peut être choisie et ajustée en fonction des beso

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25

Manea, Vladimir. "Penning-trap mass measurements of exotic rubidium and gold isotopes for a mean-field study of pairing and quadrupole correlations." Thesis, Paris 11, 2014. http://www.theses.fr/2014PA112246/document.

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Les noyaux les plus complexes sont situés entre les nombres magiques et les médianes des espaces de valence, dans des régions connues pour les changements abrupts des observables nucléaires. Dans ces régions appelées de transition de forme, le paradigme nucléaire change entre la goutte liquide vibrationnelle et le rotor statique. Sauf quelques exceptions, les noyaux de ces régions sont radioactifs, avec des demi-vies qui chutent dans les millisecondes. Complémentaires aux propriétés des états excités à basse énergie, les énergies de liaison et les rayons de charge nucléaires sont parmi les obs

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26

Lemire, Sharon Warford. "Rigorous analytical applications of liquid secondary ion mass spectrometry/mass spectrometry." Diss., Georgia Institute of Technology, 1996. http://hdl.handle.net/1853/30026.

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27

Dabney, David E. "Analysis of Synthetic Polymers by Mass Spectrometry and Tandem Mass Spectrometry." University of Akron / OhioLINK, 2009. http://rave.ohiolink.edu/etdc/view?acc_num=akron1259021862.

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28

Staněk, Jan. "Kvantitativní analýza matricových prvků metodami SIMS a LEIS." Master's thesis, Vysoké učení technické v Brně. Fakulta strojního inženýrství, 2019. http://www.nusl.cz/ntk/nusl-402575.

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This thesis studies comparison and connection of two spectrometric methods – low energy ion scattering spektrometry (LEIS) and secondary ion mass spectrometry (SIMS). SIMS method, despite its many positive qualities, suffers of so called matrix effect, which makes quantifiaction of data very difficult. LEIS method on the other hand is immune to this effect and so it’s suitable completion of SIMS method. As a convenient sample have been chosen AlGaN samples with various concentration of gallium and aluminium. In the first part of thesis is introduced physical essence of SIMS and LEIS method, ex

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29

Goodwin, Lee. "Capillary electrophoresis-mass spectrometry and tandem mass spectrometry studies of ionic agrochemicals." Thesis, University of York, 2003. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.398906.

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30

Shliaha, Pavel Vyacheslavovich. "Investigation of protein abundance and localization by mass spectrometry and ion-mobility spectrometry-mass spectrometry methods." Thesis, University of Cambridge, 2015. https://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.708661.

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31

Yuen, Wei Hao. "Ion imaging mass spectrometry." Thesis, University of Oxford, 2012. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.564395.

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This work investigates the applicability of fast detectors to the technique of microscope-mode imaging mass spectrometry. By ionising analyte from a large area of the sample, and projecting the desorbed ions by the use of ion optics through a time-of-flight mass spectrometer onto a two- dimensional detector, time- (and hence mass-) dependent distributions of ions may be imaged. To date, this method of imaging mass spectrometry has been limited by the ability to image only one mass window of interest per experimental cycle, limiting throughput and processing speed. Thus, the alternative micropr

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32

Berezovskaya, Yana. "Investigation of protein-ion interactions by mass spectrometry and ion mobility mass spectrometry." Thesis, University of Edinburgh, 2012. http://hdl.handle.net/1842/7747.

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Protein‐ion interactions play an important role in biological systems. A considerable number of elements (estimated 25 – 30) are essential in higher life forms such as animals and humans, where they are integral part of enzymes involved in plethora of cellular processes. It is difficult to overestimate the importance of thorough understanding of how protein‐ion interplay affects living cell in order to be able to address therapeutic challenges facing humanity. Presented to the reader’s attention is a gas‐phase biophysical analysis of peptides’ and proteins’ interactions with biologically relev

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33

Liu, Xiumin. "Mass Spectrometry and Tandem Mass Spectrometry Analysis of Polymers and Polymer-Protein Interactions." University of Akron / OhioLINK, 2014. http://rave.ohiolink.edu/etdc/view?acc_num=akron1406838246.

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34

Kaleta, Erin. "Applications of mass spectrometry to bacterial diagnostics: Affinity capture matrix assisted laser desorption/ionization mass spectrometry and polymerase chain reaction mass spectrometry." Diss., The University of Arizona, 2011. http://hdl.handle.net/10150/305352.

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This dissertation presents the application of mass spectrometry to the detection and characterization of microorganisms based on biomarker identification and DNA analysis. Two major topics are covered: affinity capture mass spectrometry using immunoassay methods and methods involving insertion of membrane receptors into polymerized planar supported lipid bilayers; and the application of mass spectrometry for use in clinical microbiology for the identification of microorganisms causing bloodstream infections. Affinity capture mass spectrometry on immunoassay-based platforms studied the captu

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35

Sun, Xiaobo. "Forensic Applications of Gas Chromatography/Mass Spectrometry, High Performance Liquid Chromatography--Mass Spectrometry and Desorption Electrospray Ionization Mass Spectrometry with Chemometric Analysis." Ohio University / OhioLINK, 2012. http://rave.ohiolink.edu/etdc/view?acc_num=ohiou1329517616.

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Woods, Lucy Ann. "Characterising amyloid assembly using ion mobility spectrometry-mass spectrometry." Thesis, University of Leeds, 2012. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.590277.

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From small molecules to macromolecules, mass spectrometry has evolved significantly over the past decade, progressing from a tool to identify chemical elements to a powerful technique able to elucidate structural information for large protein complexes. With the interfacing of ion mobility spectrometry to mass spectrometry (IMS-MS), mass spectrometric analyses now occupy an extra dimension, providing unrivalled separation and structural characterisation of lowly-populated species in heterogeneous mixtures. One biological system that has benefitted enormously from such advances is the study of

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Zhou, Yi. "Microfluidics interfacing to mass spectrometry." College Park, Md. : University of Maryland, 2007. http://hdl.handle.net/1903/7402.

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Thesis (Ph. D.) -- University of Maryland, College Park, 2007.<br>Thesis research directed by: Mechanical Engineering. Title from t.p. of PDF. Includes bibliographical references. Published by UMI Dissertation Services, Ann Arbor, Mich. Also available in paper.

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Testino, Samuel A. Jr. "Optimization strategies in mass spectrometry." Thesis, Georgia Institute of Technology, 1994. http://hdl.handle.net/1853/26972.

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Rostom, Adam A. "Mass spectrometry of protein interactions." Thesis, University of Oxford, 1999. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.312385.

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Winter, David. "Drug analysis by mass spectrometry." Thesis, University of Canterbury. Chemistry, 1986. http://hdl.handle.net/10092/6560.

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1. The pharmacokinetics of morphine have been measured in four patients with renal failure and three healthy volunteers following intramuscular administration of papaveretum. Morphine blood levels were determined using GCMS with specific ion monitoring. The significantly shorter drug elimination half-life found for the patients suggests that renal failure does not impair the elimination of morphine. 2. A CI GCMS assay with specific ion monitoring has been developed for measuring the anti parkinsonian drug benztropine in post-mortem specimens. The assay is potentially more sensitive than a sim

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Perkins, John Robert. "Supercritical fluid chromatography/mass spectrometry." Thesis, Cardiff University, 1989. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.375969.

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Smith, Derek John. "Femtosecond Laser Mass Spectrometry (FLMS)." Thesis, University of Glasgow, 1998. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.264149.

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Sweet, Steve M. M. "Phosphoprotein analysis by mass spectrometry." Thesis, University of Manchester, 2005. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.538385.

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Cobice, Diego Federico. "Mass spectrometry imaging of steroids." Thesis, University of Edinburgh, 2015. http://hdl.handle.net/1842/21032.

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Glucocorticoids are steroid hormones involved in the stress response, with a well-established role in promoting cardiovascular risk factors including obesity and diabetes. The focus of glucocorticoid research has shifted from understanding control of blood levels, to understanding the factors that control tissue steroid concentrations available for receptor activation; it is disruption of these tissue-specific factors that has emerged as underpinning pathophysiological mechanisms in cardiovascular risk, and revealed potential therapeutic targets. However, the field is hampered by the inability

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Salter, Tara La Roche. "Metrology for ambient mass spectrometry." Thesis, University of Nottingham, 2015. http://eprints.nottingham.ac.uk/28748/.

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Ambient mass spectrometry (AMS) is a new and versatile method for analysing a multitude of different sample types with the benefit of analysis at ambient pressure and the many other advantages that this entails. However, as these techniques are still in their infancy, metrological development of the techniques is essential. This is a critical step before AMS can be used reliably in the application areas in which it has shown great promise. The research in this thesis addresses the development of AMS sources, in particular plasma-assisted desorption-ionisation, PADI. Optimisation and characteri

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McClure, Thomas Dale. "Biomedical applications of mass spectrometry." Diss., The University of Arizona, 1991. http://hdl.handle.net/10150/185490.

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The application of mass spectrometry to verification of the structure of 3-methyluridine (m³U) isolated by HPLC from normal human urine is described. m³U has been used as an internal standard for studies of urinary nucleosides, a practice that is discouraged with the confirmation of m³U as a naturally occurring compound. Mass spectrometry has been used for the identification of 5'-deoxyxanthosine (5'-dX) a novel nucleoside in normal human urine. Initial concern over availability of a reference sample of 5'-dX prompted investigations of the structure/fragmentation relationships of the TMS derat

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Offei, Felix. "Denoising Tandem Mass Spectrometry Data." Digital Commons @ East Tennessee State University, 2017. https://dc.etsu.edu/etd/3218.

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Protein identification using tandem mass spectrometry (MS/MS) has proven to be an effective way to identify proteins in a biological sample. An observed spectrum is constructed from the data produced by the tandem mass spectrometer. A protein can be identified if the observed spectrum aligns with the theoretical spectrum. However, data generated by the tandem mass spectrometer are affected by errors thus making protein identification challenging in the field of proteomics. Some of these errors include wrong calibration of the instrument, instrument distortion and noise. In this thesis, we pres

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SPEZZANO, ROBERTO. "Lipids and Mass Spectrometry Application." Doctoral thesis, Università degli Studi di Milano, 2019. http://hdl.handle.net/2434/647470.

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During my PhD courses I focused attention on the applications of mass spectrometry in lipidomic studies. I applied mass spectrometry in several experimental models to try to observe differences in selected metabolites affected by a particular pathology. The first project performed in experimental model of impaird lipogenesis highlighted a cross talk between altered fatty acid synthesis and neuroactive steroid levels. The second project, mass spectrometry application allows to understand he effect of short-term diabetes on cholesterol metabolism. In the last project lipidomic pattern was i

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Mohan, Krishnan R. "Fast atom bombardment mass spectrometry and tandem mass spectrometry : conditions for measurement of reproducible spectra." Thesis, Georgia Institute of Technology, 1993. http://hdl.handle.net/1853/27159.

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Catron, Brittany Lyn. "Analysis of Protein:RNA Cross-links by Inductively Coupled Plasma Mass Spectrometry and Tandem Mass Spectrometry." University of Cincinnati / OhioLINK, 2012. http://rave.ohiolink.edu/etdc/view?acc_num=ucin1337885809.

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