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Dissertations / Theses on the topic 'Mass spectrometry proteomics in Ruby'

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Published: 4 June 2021

Last updated: 10 February 2022

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1

Frank, Ari Michael. "Algorithms for tandem mass spectrometry-based proteomics." Diss., Connect to a 24 p. preview or request complete full text in PDF format. Access restricted to UC campuses, 2008. http://wwwlib.umi.com/cr/ucsd/fullcit?p3307704.

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Thesis (Ph. D.)--University of California, San Diego, 2008.<br>Title from first page of PDF file (viewed August 13, 2008). Available via ProQuest Digital Dissertations. Vita. Includes bibliographical references (p. 187-205).

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2

Qiu, Haibo. "Mass spectrometry-based chemical and quantitative proteomics." Diss., [Riverside, Calif.] : University of California, Riverside, 2009. http://gateway.proquest.com/openurl?url_ver=Z39.88-2004&rft_val_fmt=info:ofi/fmt:kev:mtx:dissertation&res_dat=xri:pqdiss&rft_dat=xri:pqdiss:3350081.

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Thesis (Ph. D.)--University of California, Riverside, 2009.<br>Includes abstract. Title from first page of PDF file (viewed March 8, 2010). Includes bibliographical references. Issued in print and online. Available via ProQuest Digital Dissertations.

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3

Kang, Huan. "Mass Spectrometry Based Proteomics and Lipidomics Studies." BYU ScholarsArchive, 2015. https://scholarsarchive.byu.edu/etd/6161.

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Mass spectrometry has emerged as having a vital role in various applications to biochemical fields. In this thesis, we have utilized a variety of mass spectrometry techniques for both bacteriophage proteomics and colostrum and milk lipidomics studies. Our first study was the proteome characterization of Great Salt Lake bacteriophage NS01 with SDS-PAGE GEL to separate the viral proteins and high performance liquid chromatography (HPLC) coupled with an LTQ Orbitrap to identify the proteins after in-gel digestion. In this project, we have successfully identified 11 proteins with high confidence,

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4

Nagaraj, Nagarjuna. "Developing mass spectrometry towards applications in clinical proteomics." Diss., lmu, 2010. http://nbn-resolving.de/urn:nbn:de:bvb:19-134131.

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Gkanatsiou, Eleni. "Mass Spectrometry Based Proteomics : Toward understanding neuropathic pain." Thesis, Uppsala universitet, Analytisk kemi, 2016. http://urn.kb.se/resolve?urn=urn:nbn:se:uu:diva-297658.

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The aim of this project was to get insight into mass spectrometry based proteomics, get familiarized with novel techniques, and obtain the operating skills with modern Orbitrap mass spectrometers. In order to achieve this, the proteome changes in neuropathic pain responses corresponding to nerve injury side in individual rat’s spinal cord were explored. We focused in protein identification and quantification of the expressed proteins in 3 different set of samples, SNL, Sham and Naive rats.

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Cudjoe, Emmanuel K. Jr. "Mass Spectrometry-Based Proteomics Analysis of Secreted Proteins." VCU Scholars Compass, 2018. https://scholarscompass.vcu.edu/etd/5571.

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Secreted proteins play important roles in many cellular functions and molecular processes. Because secreted proteins potentially enter the blood stream, they can serve as valuable measures of health and disease useful for disease diagnosis and prognosis, therapeutic target identification, and patient stratification in personalized medicine. Consequently, significant interest exists in secreted protein analysis within complex biospecimens, particularly blood but significant bioanalytical challenges including the wide protein dynamic range >10 orders of magnitude remain. The cellular secretome t

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7

Bromilow, Sophie. "Proteomics in 'free-from' foods." Thesis, University of Manchester, 2018. https://www.research.manchester.ac.uk/portal/en/theses/proteomics-in-afreefroma-foods(5793f2a1-9552-46e1-92b4-2fce7fadaa27).html.

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Wheat is the most agronomically important crop with an annual production of approximately 680 million tonnes per year over the five year period of 2008-2012 (Shewry and Tatham 2016). Wheat typically contributes about 20% of the total calorie intake in Western Europe and between 50-70% in some countries in North Africa and in West and Central Asia. It is estimated that in order to meet the continuous growing global demand wheat production needs to increase by 50% by 2050. Wheat is most commonly consumed as bread, pasta and noodles however it is also used as a food ingredient in other types of f

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Martin, Nicholas Joseph. "Surface analysis for proteomics via liquid extraction surface analysis mass spectrometry and liquid chromatography mass spectrometry." Thesis, University of Birmingham, 2016. http://etheses.bham.ac.uk//id/eprint/6493/.

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Liquid extraction surface analysis (LESA) is an ambient ionisation technique which allows direct analysis of surfaces coupled with mass spectrometry. LESA mass spectrometry has been used successfully to analyse small molecules, but there are a limited number of examples where the approach has been applied to protein analysis. The work presented here aims to develop novel applications of LESA mass spectrometry of proteins. LESA mass spectrometry was used to analyse intact proteins from polymeric membranes. The rationale for these experiments was the potential application to analyse proteins ele

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9

Müller, Lukas Niklaus. "Novel computational techniques for quantitative mass spectrometry based proteomics /." Zürich : ETH, 2008. http://e-collection.ethbib.ethz.ch/show?type=diss&nr=17802.

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10

Thalassinos, Konstantinos. "Experimental and computational studies in mass spectrometry-based proteomics." Thesis, University of Warwick, 2006. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.429755.

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11

Borg, Aaron. "Expanding the mass spectrometry toolkit for interrogating chromatin proteomics." Thesis, Imperial College London, 2016. http://hdl.handle.net/10044/1/44074.

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Chromatin is comprised of DNA and a vast network of proteins, which help structure and regulate a cell's genetic material through processes including cell differentiation, regulation of genes, and DNA repair. At the core of chromatin structure lays a nucleosome, consisting of DNA wrapped around an octameric protein complex made of histones. Histones can undergo post translational modifications (PTMs) which govern protein-protein interactions (PPIs) and ultimately control gene activation and suppression. Histone PTMs can already be quantitated using existing well defined methods such as liquid

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12

Granholm, Viktor. "The accuracy of statistical confidence estimates in shotgun proteomics." Doctoral thesis, Stockholms universitet, Institutionen för biokemi och biofysik, 2014. http://urn.kb.se/resolve?urn=urn:nbn:se:su:diva-100769.

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High-throughput techniques are currently some of the most promising methods to study molecular biology, with the potential to improve medicine and enable new biological applications. In proteomics, the large scale study of proteins, the leading method is mass spectrometry. At present researchers can routinely identify and quantify thousands of proteins in a single experiment with the technique called shotgun proteomics. A challenge of these experiments is the computational analysis and the interpretation of the mass spectra. A shotgun proteomics experiment easily generates tens of thousands of

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13

Lee, Wooram. "Protein Set for Normalization of Quantitative Mass Spectrometry Data." Thesis, Virginia Tech, 2014. http://hdl.handle.net/10919/54554.

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Mass spectrometry has been recognized as a prominent analytical technique for peptide and protein identification and quantitation. With the advent of soft ionization methods, such as electrospray ionization and matrix assisted laser desorption/ionization, mass spectrometry has opened a new era for protein and proteome analysis. Due to its high-throughput and high-resolution character, along with the development of powerful data analysis software tools, mass spectrometry has become the most popular method for quantitative proteomics. Stable isotope labeling and label-free quantitation metho

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Zhang, Shaofeng. "A study of the pyrolytic digestion of proteins by mass spectrometry." Laramie, Wyo. : University of Wyoming, 2008. http://proquest.umi.com/pqdweb?did=1800001321&sid=1&Fmt=2&clientId=18949&RQT=309&VName=PQD.

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15

Shevchenko, Anna. "Characterization of Protein Complexes and Protein Interaction Networks by Mass Spectrometry." Doctoral thesis, Saechsische Landesbibliothek- Staats- und Universitaetsbibliothek Dresden, 2004. http://nbn-resolving.de/urn:nbn:de:swb:14-1101913240562-37411.

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The major goal of this study was to develop an experimental proteomics approach for deciphering protein complexes and protein interaction networks in the budding and fission yeasts. Key steps of the employed analytical routine, including the purification of complexes and mass spectrometric identification of their subunits, were investigated in detail. Archiving, storage and handling of polyacylamide gels, visualization of protein bands and their effect on the efficiency of in-gel digestion and mass spectrometric identification of proteins were quantitatively evaluated. It was further demonstra

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Liska, Adam J. "Homology-Based Functional Proteomics By Mass Spectrometry and Advanced Informatic Methods." Doctoral thesis, Saechsische Landesbibliothek- Staats- und Universitaetsbibliothek Dresden, 2003. http://nbn-resolving.de/urn:nbn:de:swb:14-1071757497859-43887.

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Functional characterization of biochemically-isolated proteins is a central task in the biochemical and genetic description of the biology of cells and tissues. Protein identification by mass spectrometry consists of associating an isolated protein with a specific gene or protein sequence in silico, thus inferring its specific biochemical function based upon previous characterizations of that protein or a similar protein having that sequence identity. By performing this analysis on a large scale in conjunction with biochemical experiments, novel biological knowledge can be developed. The study

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Brian, Carrillo. "Optimization of data directed acquisition in tandem mass spectrometry for proteomics." Thesis, McGill University, 2004. http://digitool.Library.McGill.CA:80/R/?func=dbin-jump-full&object_id=80003.

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LC-QTOF tandem mass spectrometers behave according to user controlled switching parameters, duty-cycle and repetition rate, which guide the selection of peptides and the timing of their fragmentation. Using a novel algorithm which analyses all spectra simultaneously, it has been found that the majority of available peptides are not fragmented with the current switching scheme. Unfortunately, it is not practical to experiment with the mass spectrometer to determine optimal switching parameters. In this study, simulation coupled with intensity surface analysis was used as a method of evaluating

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18

Slade, Susan E. "Application of label-free mass spectrometry-based proteomics to biomarker discovery." Thesis, University of Warwick, 2013. http://wrap.warwick.ac.uk/57747/.

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Mass spectrometry is an analytical technique which is used extensively in the fields of chemistry and physics. Developments in the field over the last two decades have permitted the analysis of a wide variety of biological molecules from a range of sources. The term proteomics relates to the study of the protein complement of a cell or organism with particular interest in the identification and quantification of these analytes. A biomarker is a characteristic that can be measured and evaluated to give an indication of normal, biological processes, or pharmacological responses to a therapeutic

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Ranbaduge, Nilini Sugeesha. "Mass Spectrometry-Based Clinical Proteomics for Non-Small Cell Lung Cancer." The Ohio State University, 2016. http://rave.ohiolink.edu/etdc/view?acc_num=osu1469103007.

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Flowers, Antwoine. "Mass-spectrometry Based Proteomics of Age-related Changes in Murine Microglia." Scholar Commons, 2017. http://scholarcommons.usf.edu/etd/6840.

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The last century has seen a steady increase in the extension of the average lifespan. This has concomitantly produced higher incidences of age-related chronic degenerative diseases like Alzheimer’s and Parkinson’s diseases. Age is the single greatest risk factor for the development of not just these degenerative conditions but cancer as well. The aged niche undergoes a number of maladaptive changes that allow underlying conditions to present and progress. Exactly which changes, contribute to the progression of which disease is currently an area of intense study. However, these answers oft

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Tabb, David L. "Bioinformatics of proteomic tandem mass spectra : selection, characterization, and identification /." Thesis, Connect to this title online; UW restricted, 2003. http://hdl.handle.net/1773/10847.

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22

Matsumiya, Nozomi. "Optimization of disulfide mapping using mass spectrometry." Thesis, Kansas State University, 2009. http://hdl.handle.net/2097/1358.

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Master of Science<br>Biochemistry<br>John Tomich<br>One of the important keys to characterize the biological function of a protein is the study of post-translational modification (PTM). Formation of disulfide bond linkages between cysteine residues within a protein is a common PTM which not only contributes to folding and stabilizing the protein structure, but also to accomplishing its native function. Therefore, the study and discovery of structural-functional relationships of expressed proteins using an isolated proteomics approach has been one of the biggest advances within the field of s

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O'Brien, Ann M. "Environmental proteomics and mass spectrometry characterization of viable microorganisms in ambient air /." Access to citation, abstract and download form provided by ProQuest Information and Learning Company; downloadable PDF file, 436 p, 2007. http://proquest.umi.com/pqdweb?did=1397906961&sid=3&Fmt=2&clientId=8331&RQT=309&VName=PQD.

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Boström, Tove. "High-throughput protein analysis using mass spectrometry-based methods." Doctoral thesis, KTH, Proteinteknologi, 2014. http://urn.kb.se/resolve?urn=urn:nbn:se:kth:diva-154513.

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In the field of proteomics, proteins are analyzed and quantified in high numbers. Protein analysis is of great importance and can for example generate information regarding protein function and involvement in disease. Different strategies for protein analysis and quan- tification have emerged, suitable for different applications. The focus of this thesis lies on protein identification and quantification using different setups and method development has a central role in all included papers. The presented research can be divided into three parts. Part one describes the develop- ment of two diff

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Yang, Xu. "Quantitative Approaches for Protein Differential Expression Analysis." Thesis, Virginia Tech, 2009. http://hdl.handle.net/10919/36172.

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In this work, tandem mass spectrometry (MS/MS)-based quantitative protocols were developed to facilitate differential protein expression analysis and biomarker discovery via a two-step sample interrogation strategy: (a) global protein profiling and differential expression analysis by spectral counting; and, (b) biomarker candidate validation by targeted screening, i.e., multiple reaction monitoring (MRM). Preliminary experiments were performed to evaluate the performance of the spectral counting method. The method proved to be applicable for proteins with spectral countsâ ¥2, and a close-to-l

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Couto, Narciso Alves Da silva. "Partition and turnover of glutathione reductase in Saccharomyces cerevisiae : a proteomic approach." Thesis, University of Manchester, 2011. https://www.research.manchester.ac.uk/portal/en/theses/partition-and-turnover-of-glutathione-reductase-in-saccharomyces-cerevisiae-a-proteomic-approach(5f813b0d-4742-4f7a-b4bd-a4e309e9e68c).html.

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The main work presented in this thesis describes proteomics strategies applied to study the trafficking and turnover of glutathione reductase (Glr1) isoforms in the cytosol and mitochondria of Saccharomyces cerevisiae. Additional work was performed in order to understand mass spectrometric response factors and how they can affect peptides representation in the mass spectra. The opportunity to study two sub proteomes involved in biofilm formation of Pseudomonas aeruginosa PAO1 arose during my PhD and their analysis is also presented. Glr1 is a low abundant protein involved in the defence mechan

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27

Balluff, Benjamin. "MALDI imaging mass spectrometry in clinical proteomics research of gastric cancer tissues." Diss., lmu, 2013. http://nbn-resolving.de/urn:nbn:de:bvb:19-155986.

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Carrillo, Brian. "Methodologies for accurate estimation of protein abundance for mass spectrometry based proteomics." Thesis, McGill University, 2010. http://digitool.Library.McGill.CA:80/R/?func=dbin-jump-full&object_id=94981.

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In quantitative proteomics, the intensity of a peptide ion in mass spectra is an estimate of that peptide's abundance. The algorithms used in quantitative proteomics attempt to use peptide intensities to estimate protein abundance information. Quantitative proteomics is a rather new sub-field of proteomics; and, therefore, many of its methods and algorithms have not yet been studied in detail or optimized. This thesis investigates the optimal use of peptide intensities to predict protein abundances. The work presented is comprised of four manuscripts that develop solutions for four key problem

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Pernemalm, Maria. "Cancer proteomics method development for mass spectrometry based analysis of clinical materials /." Stockholm : Karolinska institutet, 2009. http://diss.kib.ki.se/2009/978-91-7409-656-9/.

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Liu, Xiaoyun. "Development of mass spectrometry-based proteomics and its applications in biological systems." [Bloomington, Ind.] : Indiana University, 2009. http://gateway.proquest.com/openurl?url_ver=Z39.88-2004&rft_val_fmt=info:ofi/fmt:kev:mtx:dissertation&res_dat=xri:pqdiss&rft_dat=xri:pqdiss:3344588.

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Thesis (Ph. D.)--Indiana University, Dept. of Chemistry, 2009.<br>Title from PDF t.p. (viewed Oct. 7, 2009). Source: Dissertation Abstracts International, Volume: 70-02, Section: B, page: 0989. Adviser: David E. Clemmer. Includes supplementary digital materials.

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Grassl, Julia. "Breast cancer serum proteomics : sample processing and protein profiling by mass spectrometry." Thesis, Swansea University, 2007. https://cronfa.swan.ac.uk/Record/cronfa42525.

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The aim of this project was to develop a method for discovery of biomarkers or a protein pattern, as a signature of breast cancer. Early detection of breast cancer is crucial to increase the survival rates of patients. Little was published about biomarker discovery from serum using mass spectrometry, so over the course of the project each factor of the methodology was analysed and optimized. It was shown that standardisation of sample preparation and handling is critical for any quantitative study. The presence of albumin and other highly abundant proteins in serum interferes with proteomic an

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Ng, Daniel. "Investigating the dynamics of adhesion complex turnover by mass spectrometry based proteomics." Thesis, University of Manchester, 2013. https://www.research.manchester.ac.uk/portal/en/theses/investigating-the-dynamics-of-adhesion-complex-turnover-by-mass-spectrometry-based-proteomics(4e6d3051-c007-4715-a290-9acfd45d38a7).html.

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Adhesion complexes (ACs) are large macromolecular complexes of integrins and associated proteins that connect the actin cytoskeleton to the extracellular matrix. In migrating cells, ACs are highly dynamic -- forming and maturing at the cell front and disassembling at the cell rear. The turnover of ACs enables and localises the necessary traction forces required for cell migration. There is evidence for the spatiotemporal recruitment of specific proteins during AC maturation or disassembly; however, a holistic understanding of the compositional changes to ACs during these states is lacking. To

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Blakeley, Paul. "Computational proteomics for genome annotation." Thesis, University of Manchester, 2013. https://www.research.manchester.ac.uk/portal/en/theses/computational-proteomics-for-genome-annotation(e48dc673-a8b7-4c78-93ca-aab0eb28ec8a).html.

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The field of proteogenomics operates at the interface between proteomics and genomics, and has emerged during the past decade to exploit the vast quantities of high-throughput sequence data. A range of different proteogenomics approaches have been developed, which integrate mass spectrometry data with genome sequence data to provide empirical evidence for protein-coding genes. However, current methods may not be optimized as they do not fully consider the splicing complexity in eukaryotes and there is currently no best practice method. To address this, we investigate the level of proteomics su

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Svensson, Marcus. "Neuropeptidomics expanding proteomics downwards /." Doctoral thesis, Uppsala : Uppsala universitet, Fakultetsövergripande enheter, Acta Universitatis Upsaliensis, 2007. http://urn.kb.se/resolve?urn=urn:nbn:se:uu:diva-7465.

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35

Pierce, Carrie. "High throughput mass spectrometry for microbial identification." Diss., Georgia Institute of Technology, 2011. http://hdl.handle.net/1853/43741.

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Bacteria cause significant morbidity and mortality throughout the world, including deadly diseases such as tuberculosis, meningitis, cholera, and pneumonia. Timely and accurate bacterial identification is critical in areas such as clinical diagnostics, environmental monitoring, food safety, water and air quality assessment, and identification of biological threat agents. At present, there is an established need for high throughput, sensitive, selective, and rapid methods for the detection of pathogenic bacteria, as existing methods, while nominally effective, have failed to sufficiently redu

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Cunningham, Connell Glish Gary L. "Improved methods of tandem mass spectrometry for proteomics applications in a quadrupole ion trap mass spectrometer." Chapel Hill, N.C. : University of North Carolina at Chapel Hill, 2006. http://dc.lib.unc.edu/u?/etd,217.

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Thesis (Ph. D.)--University of North Carolina at Chapel Hill, 2006.<br>Title from electronic title page (viewed Oct. 10, 2007). " ... in partial fulfillment of the requirements for the degree of Doctor of Philosophy in the Department of Chemistry. Chapel Hill 2006." Discipline: Chemistry; Department/School: Chemistry.

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Metivier, Rebecca. "Chemical Proteomics of Reactive Cysteine Residues in Two Disease Models:." Thesis, Boston College, 2019. http://hdl.handle.net/2345/bc-ir:108645.

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Thesis advisor: Jianmin . Gao<br>Cysteine residues perform many essential cellular functions, including nucleophilic and redox catalysis, metal coordination, structural stabilization and cellular protection. Cysteine-related mutations are oftentimes related to diseases due to the amino acid’s functional importance. This has led cysteine to become a focus of small molecule drug discovery. A comparison of the cysteine proteome of diseased cells versus healthy cells can elucidate novel cysteine residues that play an important role in progressing the disease state. Two disease models were chosen t

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Chaput, Dale. "Mass Spectrometry-Based Investigation of APP-Dependent Mechanisms in Neurodegeneration." Scholar Commons, 2015. http://scholarcommons.usf.edu/etd/5921.

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Alzheimer’s disease (AD) is the most prevalent form of dementia affecting the elderly, and as the aging population increases the social and economic burden of AD grows substantially. Pathological hallmarks of AD include the accumulation of extracellular amyloid plaques and intracellular neurofibrillary tangles (NFTs), as well as significant neuron loss. Amyloid plaques consist of aggregated amyloid beta (Aβ) peptide, which is generated from the proteolytic processing of amyloid precursor protein (APP) in addition to several other peptides. While the processing of APP has been characterized, it

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Lee, Dave. "Informatics tools for the analysis and assignment of phosphorylation status in proteomics." Thesis, University of Manchester, 2015. https://www.research.manchester.ac.uk/portal/en/theses/informatics-tools-for-the-analysis-and-assignment-of-phosphorylation-status-in-proteomics(48d2cc82-5bb2-4f07-9cdd-670467db4378).html.

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Presently, progress in the field of phosphoproteomics has been accelerated by mass spectrometry. This is not a surprise owing to not only the accuracy, precision and high-throughput capabilities of MS but also due to the support it receives from informaticians whom allow the automated analysis; making the task of going from a complex sample to a statistically satisfactory set of phosphopeptides and corresponding site positions with relative ease. However, the process of identifying and subsequently pinpointing the phosphorylation moiety is not straightforward and remains a challenging task. Fu

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Koutroukides, Theodoros Alexis. "Serum proteome profiling using amine-reactive isobaric tagging mass spectrometry in schizophrenia." Thesis, University of Cambridge, 2013. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.607699.

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Kumar, Chanchal. "Bioinformatics methods and applications for functional analysis of mass spectrometry based proteomics data." Diss., lmu, 2008. http://nbn-resolving.de/urn:nbn:de:bvb:19-124512.

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Liang, Xiao. "Computational methods to estimate error rates forpeptide identifications in mass spectrometry-based proteomics." Thesis, KTH, Numerisk analys, NA, 2013. http://urn.kb.se/resolve?urn=urn:nbn:se:kth:diva-124027.

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In the field of proteomics, tandem mass spectrometry is the core technology which promises to identify peptide components within complex mixtures on a large scale. Currently the bottleneck is to reduce the error rates and assign accurate statistical estimates of peptide identifications. In this work, we introduce the techniques of identifying chimeric spectra, where two or more precursor ions with similar mass and retention time are co-fragmented and sequenced by the MS/MS instrument. Based on this, we try to analyze the factor which leads to the high error rate of identifications. We show tha

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Williams, Taufika Ialam. "Methods development in biological mass spectrometry applications in small molecule research and proteomics /." Lexington, Ky. : [University of Kentucky Libraries], 2005. http://lib.uky.edu/ETD/ukychem2005d00368/tiwdis.pdf.

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Thesis (Ph. D.)--University of Kentucky, 2005.<br>Title from document title page (viewed on January 19, 2006). Document formatted into pages; contains: xiv, 247 p. :ill. (some col.). Includes abstract and vita. Includes bibliographical references (p. 224-244).

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Sihlbom, Carina. "Mass spectrometry for comparative proteomics of degenerative and regenerative processes in the brain /." Göteborg : Institute of Biomedicine, Sahlgrenska Academy, Göteborg University, 2006. http://hdl.handle.net/2077/774.

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Ammar, Constantin [Verfasser], and Ralf [Akademischer Betreuer] Zimmer. "Context-based analysis of mass spectrometry proteomics data / Constantin Ammar ; Betreuer: Ralf Zimmer." München : Universitätsbibliothek der Ludwig-Maximilians-Universität, 2020. http://d-nb.info/1221524488/34.

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Williams, Taufika Islam. "METHODS DEVELOPMENT IN BIOLOGICAL MASS SPECTROMETRY: APPLICATIONS IN SMALL MOLECULE RESEARCH AND PROTEOMICS." UKnowledge, 2005. http://uknowledge.uky.edu/gradschool_diss/288.

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Technological developments have enabled mass spectrometry (MS) to evolve asone of the most versatile, sensitive and widely used analytical methods. Key areas ofresearch in biological MS include the development of analyte-selective MSmethodologies, along with the design of MS compatible separation technology. Analytesof interest range from small, biologically active molecules in disease progressionresearch, to macromolecules such as proteins, in proteomics investigations. Advances inthese areas are vital to maintaining the level of sophistication that has become thebenchmark for MS analyses.Mas

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Graßl, Niklas Severin [Verfasser], and Sören [Akademischer Betreuer] Schubert. "Mass spectrometry based proteomics in medical diagnostics / Niklas Severin Graßl ; Betreuer: Sören Schubert." München : Universitätsbibliothek der Ludwig-Maximilians-Universität, 2019. http://d-nb.info/119266342X/34.

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Schienschang, Amy Swayne. "Monitoring Infection of E. Coli By Bacteriophage T7 through Mass Spectrometry-Based Proteomics." W&M ScholarWorks, 2018. https://scholarworks.wm.edu/etd/1550154018.

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Mass spectrometry-based proteomics has become an important and versatile tool in analytical chemistry, making sense of complex biological samples and shedding light on the intricate proteomes of living organisms. Bottom-up proteomics studies are used to elucidate the changes in gene expression of bacteriophage T7 over the course of infection of Escherichia coli. E. coli cultures were infected with T7, sampled over time, and proteins were isolated and enzymatically digested. Nanoflow liquid chromatography combined with tandem mass spectrometry was used to detect proteolytic peptides and identif

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Dowle, Adam Ashley. "Leveraging the power of mass spectrometry-based proteomics to reveal novel biological insights." Thesis, University of York, 2016. http://etheses.whiterose.ac.uk/15722/.

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Mass spectrometry-based proteomics has the potential to offer new qualitative and quantitative insights into a wide array of biological questions. The work presented in this thesis, including the associated submitted papers, evidences my contribution to this field. Paper 1 demonstrates the successful identification of post translational modifications imparted upon histones following DNA damage. Papers 2-4 employ a label-free quantification approach to study the immunomodulation molecules endemic parasites use to impair host resistance. Paper 5 uses an isobaric tagging approach to quantify chan

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50

Song, Zhao Xu Dong. "Bioinformatics methods for protein identification using peptide mass fingerprinting data." Diss., Columbia, Mo. : University of Missouri--Columbia, 2009. http://hdl.handle.net/10355/6125.

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Title from PDF of title page (University of Missouri--Columbia, viewed on Feb 16, 2010). The entire thesis text is included in the research.pdf file; the official abstract appears in the short.pdf file; a non-technical public abstract appears in the public.pdf file. Dissertation advisor: Dr. Dong Xu. Vita. Includes bibliographical references.

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