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Journal articles on the topic 'Mass Spectrometry technique'

Author: Grafiati

Published: 9 March 2023

Last updated: 31 July 2025

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1

Archita, Tiwari, Dubey Vishwanath, Mishra Shilpi, et al. "General Instrumentation of LC-MS Technique and their Recent Applications." International Journal of Innovative Science and Research Technology 7, no. 5 (2022): 1469–73. https://doi.org/10.5281/zenodo.6760060.

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This review summarizes the advancement in liquid chromatography-mass spectrometry (LC-MS). Liquid Chromatography and Mass Spectrometer is a hyphenated technique of separation of compounds. over the past years, the combination 0f high-performance liquid chromatography and mass spectrometry (LC-MS) has been used which has a remarkable effect on drug research and development. LC-MS played a vital role in the assessment and interpretation of bioavailability and bioequivalence. This article reviews the principle of LCMS analysis using liquid chromatography and mass spectrometry. Mass spectrometry c

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2

R Swetha Sri, B Aishwarya, D Vaishnavi, and M Sumakanth. "A review on ion mobility mass spectrometry." Open Access Research Journal of Biology and Pharmacy 6, no. 2 (2022): 013–23. http://dx.doi.org/10.53022/oarjbp.2022.6.2.0067.

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Mass Spectrometry can be coupled with ion mobility to get results that cannot be obtained by alone mass spectrometry. This coupled instrument can be used for knowing the separation of isomers, isobars, and conformers, the reduction of chemical noise, and the measurement of ion size. It divides ions into families of ions as well as ions with the same charge and similar structural properties. The four ion mobility separation techniques currently applied to mass spectrometry are described in this article. Low-resolution mobility separation is demonstrated by AIMS. Offering continuous ion monitori

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3

Szpunar, J., and R. Lobinski. "Species-selective Analysis for Metal - Biomacromolecular Complexes using Hyphenated Techniques." Pure and Applied Chemistry 71, no. 5 (1999): 899–918. http://dx.doi.org/10.1351/pac199971050899.

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Analytical chemistry of metal complexes with biomacromolecules based on the coupling of a high resolution separation technique with an element or species selective detection technique is critically discussed. The role of size-exclusion chromatography (SEC) with on-line atomic spectrometric detection is evaluated for the characterization of the metal distribution among the fractions of different molecular weight. Attention is given to the conditions for the separation of metallated biomacromolecular isoforms and sub-isoforms by anion-exchange and reversed-phase HPLC. Techniques for interfacing

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4

Khan, Hamid. "UHPLC-MS/MS Technique: Applications in Analytical Chemistry." Asian Journal of Chemistry 36, no. 4 (2024): 766–78. http://dx.doi.org/10.14233/ajchem.2024.31383.

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The ultra-high performance liquid chromatography-mass spectrometry/mass spectrometry (UHPLC-MS/MS) is becoming most advanced technique used for analysis of wide range of compounds in analytical chemistry. This technique has been effectively utilized for identifying and quantitatively determining substances in several pharmaceutical analysis fields. The UHPLC technique offers superior sensitivity, selectivity and peak shape in comparison to the conventional HPLC technique. The UHPLC coupled with various mass spectrometers gives accurate mass fragmentations which is ultimately helpful in structu

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5

Niwa, Toshimitsu, and Akira Shimizu. "New challenge of mass spectrometry technique." Journal of Chromatography B 855, no. 1 (2007): 1. http://dx.doi.org/10.1016/j.jchromb.2007.02.051.

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6

Chan, Daniel Shiu-Hin, Andrew J. Whitehouse, Anthony G. Coyne, and Chris Abell. "Mass spectrometry for fragment screening." Essays in Biochemistry 61, no. 5 (2017): 465–73. http://dx.doi.org/10.1042/ebc20170071.

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Fragment-based approaches in chemical biology and drug discovery have been widely adopted worldwide in both academia and industry. Fragment hits tend to interact weakly with their targets, necessitating the use of sensitive biophysical techniques to detect their binding. Common fragment screening techniques include differential scanning fluorimetry (DSF) and ligand-observed NMR. Validation and characterization of hits is usually performed using a combination of protein-observed NMR, isothermal titration calorimetry (ITC) and X-ray crystallography. In this context, MS is a relatively underutili

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7

Rogowska, Agnieszka, Małgorzata Szultka-Młyńska, Basem Kanawati, et al. "Advanced Mass Spectrometric Techniques for the Comprehensive Study of Synthesized Silicon-Based Silyl Organic Compounds: Identifying Fragmentation Pathways and Characterization." Materials 16, no. 9 (2023): 3563. http://dx.doi.org/10.3390/ma16093563.

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The primary objective of this study was to synthesize and characterize novel silicon-based silyl organic compounds in order to gain a deeper understanding of their potential applications and interactions with other compounds. Four new artificial silyl organic compounds were successfully synthesized: 1-O-(Trimethylsilyl)-2,3,4,6-tetra-O-acetyl-β-d-glucopyranose (compound 1), 1-[(1,1-dimethylehtyl)diphenylsilyl]-1H-indole (compound 2), O-tert-butyldiphenylsilyl-(3-hydroxypropyl)oleate (compound 3), and 1-O-tert-Butyldiphenylsilyl-myo-inositol (compound 4). To thoroughly characterize these synthe

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8

Davies, S., J. A. Rees, and D. L. Seymour. "Threshold ionisation mass spectrometry (TIMS); a complementary quantitative technique to conventional mass resolved mass spectrometry." Vacuum 101 (March 2014): 416–22. http://dx.doi.org/10.1016/j.vacuum.2013.06.004.

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9

Termopoli, Veronica, Maurizio Piergiovanni, Davide Ballabio, Viviana Consonni, Emmanuel Cruz Muñoz, and Fabio Gosetti. "Condensed Phase Membrane Introduction Mass Spectrometry: A Direct Alternative to Fully Exploit the Mass Spectrometry Potential in Environmental Sample Analysis." Separations 10, no. 2 (2023): 139. http://dx.doi.org/10.3390/separations10020139.

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Membrane introduction mass spectrometry (MIMS) is a direct mass spectrometry technique used to monitor online chemical systems or quickly quantify trace levels of different groups of compounds in complex matrices without extensive sample preparation steps and chromatographic separation. MIMS utilizes a thin, semi-permeable, and selective membrane that directly connects the sample and the mass spectrometer. The analytes in the sample are pre-concentrated by the membrane depending on their physicochemical properties and directly transferred, using different acceptor phases (gas, liquid or vacuum

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10

Woehlck, Harvey J., Marshall Dunning, Kasem Nithipatikom, Alexander H. Kulier, and Daniel W. Henry. "Mass Spectrometry Provides Warning of Carbon Monoxide Exposure Via Trifluoromethane." Anesthesiology 84, no. 6 (1996): 1489–93. http://dx.doi.org/10.1097/00000542-199606000-00026.

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Background The chemical breakdown of isoflurane, enflurane, or desflurane in dried carbon dioxide absorbents may produce carbon monoxide. Some mass spectrometers can give false indications of enflurane during anesthetic breakdown. Methods During clinical anesthesia with isoflurane or desflurane, the presence of carbon monoxide in respiratory gas was confirmed when enflurane was inappropriately indicated by a clinical mass spectrometer that identified enflurane at mass to charge ratio = 69. In vitro, isoflurane, enflurane, or desflurane in oxygen was passed through dried carbon dioxide absorben

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11

Vidová, Veronika, Michael Volný, Karel Lemr, and Vladimír Havlíček. "Surface analysis by imaging mass spectrometry." Collection of Czechoslovak Chemical Communications 74, no. 7-8 (2009): 1101–16. http://dx.doi.org/10.1135/cccc2009028.

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A review of four MS-based techniques available for molecular surface imaging is presented. The main focus is on the commercially available mass spectrometry imaging techniques: secondary ion mass spectrometry (SIMS), matrix assisted laser desorption ionization mass spectrometry (MALDI-MS), desorption electrospray ionization mass spectrometry (DESI-MS) and laser ablation inductively-coupled plasma mass spectrometry (LA-ICP-MS). A short historical perspective is presented and traditional desorption ionization techniques are also briefly described. The four techniques are compared mainly with res

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12

Dąbek, Józef, and Stanislaw Halas. "Physical Foundations of Rhenium-Osmium Method - A Review." Geochronometria 27, no. -1 (2007): 23–26. http://dx.doi.org/10.2478/v10003-007-0011-4.

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Physical Foundations of Rhenium-Osmium Method - A Review A newly acquired mass spectrometer MI 1201 by the Mass Spectrometry Laboratory will be adapted to determine rhenium and osmium isotope concentrations using negative thermal ionization mass spectrometry (NTIMS). We describe the principle of the Re-Os dating technique and the thermal ionization phenomena which lead to high precision isotope analysis on NTIMS.

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13

Gould, Oliver, Natalia Drabińska, Norman Ratcliffe, and Ben de Lacy Costello. "Hyphenated Mass Spectrometry versus Real-Time Mass Spectrometry Techniques for the Detection of Volatile Compounds from the Human Body." Molecules 26, no. 23 (2021): 7185. http://dx.doi.org/10.3390/molecules26237185.

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Mass spectrometry (MS) is an analytical technique that can be used for various applications in a number of scientific areas including environmental, security, forensic science, space exploration, agri-food, and numerous others. MS is also continuing to offer new insights into the proteomic and metabolomic fields. MS techniques are frequently used for the analysis of volatile compounds (VCs). The detection of VCs from human samples has the potential to aid in the diagnosis of diseases, in monitoring drug metabolites, and in providing insight into metabolic processes. The broad usage of MS has r

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14

Bhole, R. P., S. R. Jagtap, K. B. Chadar, and Y. B. Zambare. "Liquid Chromatography-Mass Spectrometry Technique-A Review." Research Journal of Pharmacy and Technology 13, no. 1 (2020): 505. http://dx.doi.org/10.5958/0974-360x.2020.00097.9.

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15

Satoh, Takaya, Kentaro Takahara, Tomoaki Kondo, Ryo Ogasawara, and Chika Nogami. "Recent data analysis technique in mass spectrometry." Japanese Journal of Pesticide Science 42, no. 1 (2017): 203–15. http://dx.doi.org/10.1584/jpestics.w17-54.

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16

Rivlin, A. A. "Sorption technique in membrane-inlet mass spectrometry." Rapid Communications in Mass Spectrometry 9, no. 5 (1995): 397–99. http://dx.doi.org/10.1002/rcm.1290090507.

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17

Jiang, Songsheng, Shan Jiang, Chunsheng Li, Ming He, Shaoyong Wu, and Silin Li. "Determination of79Se with accelerator mass spectrometry technique." Chinese Science Bulletin 42, no. 1 (1997): 30–33. http://dx.doi.org/10.1007/bf02882515.

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18

Lattimer, Robert P., and Robert E. Harris. "Analysis of Components in Rubber Compounds Using Mass Spectrometry." Rubber Chemistry and Technology 62, no. 3 (1989): 548–67. http://dx.doi.org/10.5254/1.3536258.

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Abstract A large number of very successful mass-spectrometric methods have been developed for rubber-compound analysis. The high sensitivity, high specificity, and superb mixture analysis capabilities of modern mass spectrometry make it an invaluable tool in the polymer industry, particularly for qualitative identification of organic additives. In many cases, mass spectrometry can provide unique information that is not available by use of any other technique.

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19

Karabagias, Ioannis K. "Advances of Spectrometric Techniques in Food Analysis and Food Authentication Implemented with Chemometrics." Foods 9, no. 11 (2020): 1550. http://dx.doi.org/10.3390/foods9111550.

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Given the continuous consumer demand for products of high quality and specific origin, there is a great tendency for the application of multiple instrumental techniques for the complete characterization of foodstuffs or related natural products. Spectrometric techniques usually offer a full and rapid screenshot of products’ composition and properties by the determination of specific bio-molecules such as sugars, minerals, polyphenols, volatile compounds, amino acids, organic acids, etc. The present special issue aimed firstly to enhance the advances of the application of spectrometric techniqu

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20

Thoren, Katie L. "Will Mass Spectrometry Replace Current Techniques for Both Routine Monitoring and MRD Detection in Multiple Myeloma?" Hemato 2, no. 4 (2021): 764–68. http://dx.doi.org/10.3390/hemato2040052.

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In recent years, mass spectrometry has been increasingly used for the detection of monoclonal proteins in serum. Mass spectrometry is more analytically sensitive than serum protein electrophoresis and immunofixation, can help distinguish therapeutic monoclonal antibodies from M-proteins, and can detect the presence of post-translational modifications. Mass spectrometry also shows promise as a less-invasive, peripheral-blood-based test for detecting minimal residual disease in multiple myeloma. Studies comparing the clinical utility of mass spectrometry to current blood- and bone-marrow-based t

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21

Garcia, Xavier, Maria Sabaté, Jorge Aubets, Josep Jansat, and Sonia Sentellas. "Ion Mobility–Mass Spectrometry for Bioanalysis." Separations 8, no. 3 (2021): 33. http://dx.doi.org/10.3390/separations8030033.

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This paper aims to cover the main strategies based on ion mobility spectrometry (IMS) for the analysis of biological samples. The determination of endogenous and exogenous compounds in such samples is important for the understanding of the health status of individuals. For this reason, the development of new approaches that can be complementary to the ones already established (mainly based on liquid chromatography coupled to mass spectrometry) is welcomed. In this regard, ion mobility spectrometry has appeared in the analytical scenario as a powerful technique for the separation and characteri

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22

Reusch, Nicola, Viola Krein, Nikolaus Wollscheid, and Karl-Michael Weitzel. "Distinction of Structural Isomers of Benzenediamin and Difluorobenzene by Means of Chirped Femtosecond Laser Ionization Mass Spectrometry." Zeitschrift für Physikalische Chemie 232, no. 5-6 (2018): 689–703. http://dx.doi.org/10.1515/zpch-2017-1051.

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Abstract Structural isomers of disubstituted benzenes are difficult to distinguish with most mass spectrometric methods. Consequently, conventional concepts for the distinction of isomers are based on coupling mass spectrometry with a chromatographic method. As an alternative approach, we propose the combination of femtosecond laser ionization with time-of-flight mass spectrometry (fs-LIMS). The possibility of systematic tailoring of fs-laser pulse shapes opens access to a multidimensional analytical technique capable of distinguishing structural isomers of the title molecules.

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23

Helleur, R. J., and Pierre Thibault. "Optimization of pyrolysis–desorption chemical ionization mass spectrometry and tandem mass spectrometry of polysaccharides." Canadian Journal of Chemistry 72, no. 2 (1994): 345–51. http://dx.doi.org/10.1139/v94-053.

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The operating conditions for pyrolysis–desorption ammonia chemical ionization mass spectrometry and tandem mass spectrometry have been optimized and the technique evaluated for the production and analysis of structurally-informative pyrolytic fragmentation ions corresponding to intact anhydrohexose oligosaccharides, using amylose as the model polysaccharide. Among the various parameters examined it was found that the nature of the solvent used to adhere the sample to the emitter coil and the configuration of the emitter and the rate at which it is heated all play important roles in determining

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24

Schmeer, Karl, Beate Behnke, and Ernst Bayer. "Capillary Electrochromatography-Electrospray Mass Spectrometry: A Microanalysis Technique." Analytical Chemistry 67, no. 20 (1995): 3656–58. http://dx.doi.org/10.1021/ac00116a007.

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25

Kieser, W. E., X. L. Zhao, C. Y. Soto, and B. Tracy. "Accelerator mass spectrometry of 129I: Technique and applications." Journal of Radioanalytical and Nuclear Chemistry 263, no. 2 (2005): 375–79. http://dx.doi.org/10.1007/s10967-005-0065-6.

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26

Shivani, Bharat Kumbhar*, and Kanchan Chauhan Dr. "A REVIEW ON LIQUID CHROMATOGRAPHY-MASS SPECTROMETRY TECHNIQUE." World Journal of Pharmaceutical Science and Research 4, no. 2 (2025): 809–22. https://doi.org/10.5281/zenodo.15274603.

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Chromatography could be a separation technique to separate the individual compound from a mixture using a two phase, one is stationary and second is mobile phase. The chromatography word obtained from Greek, " Chroma’’ suggests that colour and ‘‘graphein’’ mean writing, thus the word chromatography suggests that ‘‘colour writing’’. Chromatography was Initial developed by the Russian botanist ‘‘Mikhail Tswett’’ in 1903; he separated coloured arrange pigments through carbonate column.

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27

Lu, I.-Chung. "Development of a Next-Generation Ionisation Technique in Mass Spectrometry." Impact 2022, no. 1 (2022): 59–61. http://dx.doi.org/10.21820/23987073.2022.1.59.

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Mass spectrometry (MS) has a wide range of applications. Assistant Professor I-Chung Lu, Department of Chemistry, National Chung Hsing University, Taiwan, is working to improve and better understand aspects of MS in order to further broaden its possible applications. A particular focus for Lu and his team is on developing novel techniques or improving conventional ionisation methods to overcome application difficulties in MS, specifically in the detection of labile and unstable species. Those techniques extend the MS as a powerful tool to study critical reaction intermidiates and mechanisms. A

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Lyapchenko, Natalya, Rafał Frański, and Grzegorz Schroeder. "Mass Spectrometric Investigation of Protonated and Cationized Molecules of Oxaalkyl Phosphates." European Journal of Mass Spectrometry 8, no. 6 (2002): 451–60. http://dx.doi.org/10.1255/ejms.512.

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Mass spectrometric fragmentation pathways of protonated molecules of oxaalkyl phosphates and their complexes with alkali metal cations are discussed in this paper. Liquid secondary ion mass spectrometry (LSIMS) was used as the ionisation technique and mass spectra from B/E linked scans were registered to elucidate the mass spectrometric decomposition of the studied ions. Mainly loss of the ether molecules H2C=HCOCH3 and HOH2C–H2COCH3 was observed. The elimination of neutrals containing metal, for example, K-CH2CH2OCH3 or KOCH2CH2OCH3 also occurred. In the case of phosphate (III) an unusual los

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Carré, Vincent, Pierre Leroy, and Patrick Chaimbault. "Diagnosis of Biological Activities by Mass Spectrometry." Proceedings 11, no. 1 (2019): 36. http://dx.doi.org/10.3390/proceedings2019011036.

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Oxidative reactions are vital but also cause important stresses and cellular damages resulting in cancers, cardiovascular or neurodegenerative diseases. Antioxidant secondary metabolites from plant can be mobilized for the cell defense and their main source is precisely the food intake such as vegetables, fruits or beverages. Screening natural active metabolites in plants requires different analytical techniques among which mass spectrometry became one of the most popular, not just because of its ability to provide structural information on involved molecules but also because this technique be

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30

SKIMS, Editor. "MALDI-TOF mass spectrometry in clinical diagnostic microbiology." JMS SKIMS 20, no. 1 (2017): 54. http://dx.doi.org/10.33883/jms.v20i1.315.

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Microbial identification in clinical diagnostic laboratories mainly relies on conventional phenotypic and gene sequencing identification techniques. Recently development of matrix-assisted laser desorption ionization time-of-flight mass spectrometry (MALDI-TOF MS) devices has revolutionized the routine identification of microorganisms in clinical microbiology laboratories. This is an easy, rapid, high throughput, low-cost, and efficient identification technique and has been adapted to the constraint of clinical diagnostic laboratories. This technology has the potential to replace and/or comple

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31

Du, X. Y., X. Y. Liu, Z. Y. Shang, W. S. Han, and H. Zhang. "Detection techniques for monitoring dioxin-like compounds: latest techniques and the comparison." Journal of Physics: Conference Series 2045, no. 1 (2021): 012024. http://dx.doi.org/10.1088/1742-6596/2045/1/012024.

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Abstract In order to clarify the necessity and urgency of dioxin detection, the characteristics and emission sources were firstly studied in this paper. The current dioxin detection techniques were then summarized, including chemical detection technique represented by HRGC/MS, biological detection technique covering immunology and biotechnology, and laser mass spectrometry technique using fusion ionization technology and time-of-flight mass spectrometry. Then the advantages and disadvantages, representative technologies, development directions and application prospects of various detection met

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32

Urban, Pawel L. "Quantitative mass spectrometry: an overview." Philosophical Transactions of the Royal Society A: Mathematical, Physical and Engineering Sciences 374, no. 2079 (2016): 20150382. http://dx.doi.org/10.1098/rsta.2015.0382.

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Mass spectrometry (MS) is a mainstream chemical analysis technique in the twenty-first century. It has contributed to numerous discoveries in chemistry, physics and biochemistry. Hundreds of research laboratories scattered all over the world use MS every day to investigate fundamental phenomena on the molecular level. MS is also widely used by industry—especially in drug discovery, quality control and food safety protocols. In some cases, mass spectrometers are indispensable and irreplaceable by any other metrological tools. The uniqueness of MS is due to the fact that it enables direct identi

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Rathore, Surbhi. "A Review on Liquid Chromatography-Mass Spectrometry (LC-MS)." International Journal for Research in Applied Science and Engineering Technology 13, no. 3 (2025): 844–48. https://doi.org/10.22214/ijraset.2025.67278.

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The hyphenation of liquid chromatography with mass spectrometry allows for the simultaneous analysis of compounds based on their retention times and mass-to-charge ratios, providing valuable information about the identity and quantity of analytes in a sample. One of the key advantages of LC-MS is its versatility, as it can be applied to a wide range of samples including biological fluids, environmental samples, pharmaceuticals, and food products. This makes it an essential technique in fields such as pharmaceutical analysis, environmental monitoring, metabolomics, proteomics, and forensic scie

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34

Shounak, Mande*. "A Review Article on Hyphenated Techniques Used in Analytical Method and Development." International Journal of Pharmaceutical Sciences 3, no. 1 (2025): 2407–17. https://doi.org/10.5281/zenodo.14762916.

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The hyphenated techniques refers to the combination or synthesis of distinct analytical methodologies. Spectroscopic techniques are mostly paired with chromatographic techniques. After that, an interphase will allow the mixture's separated components from the chromatographic approach to enter the spectroscopic technique. In GC-MS After separation from gas chromatography, ionization and mass spectrometry are added to MS. analysis and measurement of the mass-to-charge ratios of the ions that the mass spectrometer generates from each analysis. GC and MS can be connected by a membrane separator, j

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Weinkauf, R., K. Walter, C. Weickhardt, U. Boesl, and E. W. Schlag. "Laser Tandem Mass Spectrometry in a Time of Flight Instrument." Zeitschrift für Naturforschung A 44, no. 12 (1989): 1219–25. http://dx.doi.org/10.1515/zna-1989-1216.

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Abstract We present a new laser tandem mass spectrometry technique in a reflectron time of flight (TOF) instrument. A first pulsed laser performs the multiphoton ionization and the primary photodissociation. A newly designed ion source permits a high mass resolution in the space focus of the 12 cm long first linear TOF, where then the secondary excitation can take place. For high resolution applications the pure secondary or pure metastable mass spectrum of a preselected precursor ion can be recorded using a new reflectron scanning technique. It is also possible to obtain the whole secondary m

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Akhilesh, Kumar Kuril. "Navigating Mass Spectrometry: A Comprehensive Guide to Basic Concepts and Techniques." International Journal of Scientific Development and Research 9, no. 6 (2024): 35–47. https://doi.org/10.5281/zenodo.11482323.

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Mass spectrometry (MS) is a powerful analytical technique used to determine the molecular mass and structural information of compounds by measuring the mass-to-charge ratio (m/z) of ionized molecules and their fragments. At its core, a mass spectrometer consists of three fundamental components: an ion source, a mass analyzer, and a detector. The ion source converts sample molecules into gaseous ions, typically by either removing an electron (forming positive ions) or adding an electron (forming negative ions). Common ionization techniques include electron ionization (EI), chemical ionization (

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Linton, Richard W. "Secondary ion mass spectroscopy in the biological and materials sciences." Proceedings, annual meeting, Electron Microscopy Society of America 51 (August 1, 1993): 498–99. http://dx.doi.org/10.1017/s0424820100148320.

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Secondary ion mass spectrometry (SIMS) is based upon energetic ion bombardment of surfaces resulting in in the emission of sputtered particles, including both atomic and molecular ions. The use of mass spectrometric detection provides a highly versatile and sensitive tool for surface and thin film chemical analysis. In recent years, the scope of the technique has broadened to include a variety of analysis modes including:1.Elemental Depth Profiling (dynamic SIMS),2.Laterally Resolved Imaging (ion microprobe or ion microscope analysis),3.Image Depth Profiling (combination of modes 1 and 2 provi

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Karas, Michael. "Laser Microprobe Mass Spectrometry for Spatially Resolved Organic Analysis." Proceedings, annual meeting, Electron Microscopy Society of America 48, no. 2 (1990): 306–7. http://dx.doi.org/10.1017/s0424820100135137.

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Within the last twenty years, lasers were used for sample ionization in mass spectrometry by coupling nearly any available type of laser to the different kinds of available mass analyzers. There is a broad area of applications of the so-called laser ionization/desorption mass spectrometry (LIMS, LDMS) in a large variety of fields, such as geology, mineralogy, material research, general chemistry and biochemistry ranging from determination of bulk elemental composition to molecular weight determination of biological macromolecules. By combining an UV-microscope with a short-pulse UV-laser (for

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Linton, Richard W. "Direct Imaging of Trace Elements, Isotopes, and Molecules Using Mass Spectrometry." Microscopy and Microanalysis 4, S2 (1998): 124–25. http://dx.doi.org/10.1017/s1431927600020742.

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Secondary ion mass spectrometry (SIMS) is based upon the energetic ion bombardment of surfaces resulting in in the emission of sputtered particles, including both atomic and molecular ions. The use of mass spectrometric detection provides a highly versatile and sensitive tool for surface and thin film microanalysis. The scope of the technique includes a diversity of analysis modes including:1.Elemental Depth Profiling (dynamic SIMS),2.Laterally Resolved Imaging (ion microprobe or ion microscope analysis),3.Image Depth Profiling (combination of modes 1 and 2 providing 3-D images),4.Molecular Mo

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40

Gorshkov, Michael V., Christophe D. Masselon, Gordon A. Anderson, Harold R. Udseth, Richard Harkewicz, and Richard D. Smith. "A dynamic ion cooling technique for FTICR mass spectrometry." Journal of the American Society for Mass Spectrometry 12, no. 11 (2001): 1169–73. http://dx.doi.org/10.1016/s1044-0305(01)00306-3.

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41

BORMAN, STU. "New Technique Promises To Expand Scope of Mass Spectrometry." Chemical & Engineering News 69, no. 49 (1991): 22–23. http://dx.doi.org/10.1021/cen-v069n049.p022.

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42

Kumar, Pankaj. "Accelerator Mass Spectrometry - an ultrasensitive dating and tracing technique." Journal of Physics: Conference Series 755 (October 2016): 012005. http://dx.doi.org/10.1088/1742-6596/755/1/012005.

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Adams, F., F. Michiels, M. Moens, and P. Van Espen. "Secondary-ion mass spectrometry as a quantitative microanalytical technique." Analytica Chimica Acta 216 (January 1989): 25–55. http://dx.doi.org/10.1016/s0003-2670(00)82003-6.

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Marshall, Alan G., and Lutz Schweikhard. "Fourier transform ion cyclotron resonance mass spectrometry: technique developments." International Journal of Mass Spectrometry and Ion Processes 118-119 (September 1992): 37–70. http://dx.doi.org/10.1016/0168-1176(92)85058-8.

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Vogel, Martin, and Uwe Karst. "Electrochemistry–mass spectrometry: an emerging hyphenated technique for bioanalysis." Analytical and Bioanalytical Chemistry 403, no. 2 (2012): 333–34. http://dx.doi.org/10.1007/s00216-012-5863-4.

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Rama Rao, Tadikonda, Thangadipalli Yashwanth, and Banuri Usha. "Liquid Chromatography-Mass Spectrometry: A Review." Journal of Drug Delivery and Therapeutics 14, no. 6 (2024): 298–304. http://dx.doi.org/10.22270/jddt.v14i6.6669.

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The analytical technique known as liquid chromatography-mass spectrometry is incredibly precise and sensitive. It's a really powerful tool. Detection, identification, and mass determination of components in the presence of additional components are carried out by mass spectrometry using sample eluents from liquid chromatography and mass spectrometry. Liquid chromatography is used to identify pharmaceutical medication components, intermediates, and related compounds for both quantitative and qualitative applications. Liquid chromatography is mostly used in-vitro dissolution, bioequivalence, bio

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Gove, Harry E. "Some Comments on Accelerator Mass Spectrometry." Radiocarbon 42, no. 1 (2000): 127–35. http://dx.doi.org/10.1017/s0033822200053091.

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This paper discusses some aspects of the development of accelerator mass spectrometry (AMS), the international conferences that have been held, and the books that have been written on the subject. It also mentions some details of the technique and its strengths. Some of the interesting measurements that have been made recently are covered, and finally, it presents some thoughts on future developments.

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Daniel, Yvonne, and Charles Turner. "Newborn Sickle Cell Disease Screening Using Electrospray Tandem Mass Spectrometry." International Journal of Neonatal Screening 4, no. 4 (2018): 35. http://dx.doi.org/10.3390/ijns4040035.

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There is a growing demand for newborn sickle cell disease screening globally. Historically techniques have relied on the separation of intact haemoglobin tetramers using electrophoretic or liquid chromatography techniques. These techniques also identify haemoglobin variants of no clinical significance. Specific electrospray ionization-mass spectrometry-mass spectrometry techniques to analyse targeted peptides formed after digestion of the haemoglobin with trypsin were reported in 2005. Since this time the method has been further developed and adopted in several European countries. It is estima

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Yusoff, Syarifah Adilah Mohamed, Ibrahim Venkat, Umi Kalsom Yusof, and Rosni Abdullah. "Bio-Inspired Metaheuristic Optimization Algorithms for Biomarker Identification in Mass Spectrometry Analysis." International Journal of Natural Computing Research 3, no. 2 (2012): 64–85. http://dx.doi.org/10.4018/jncr.2012040104.

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Mass spectrometry is an emerging technique that is continuously gaining momentum among bioinformatics researchers who intend to study biological or chemical properties of complex structures such as protein sequences. This advancement also embarks in the discovery of proteomic biomarkers through accessible body fluids such as serum, saliva, and urine. Recently, literature reveals that sophisticated computational techniques mimetic survival and natural processes adapted from biological life for reasoning voluminous mass spectrometry data yields promising results. Such advanced approaches can pro

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Bhardwaj, Attish. "Laconic Review on Capillary Electrophoresis-Mass Spectrometry in Separation of Proteins." International Journal for Research in Applied Science and Engineering Technology 11, no. 7 (2023): 91–97. http://dx.doi.org/10.22214/ijraset.2023.54567.

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Abstract: The separation technique known as electrophoresis is made possible by the ability of liquid molecules to travel through an electric field. Early in the 1980s, it was discovered that considerable separation efficiencies could be obtained by passing a voltage across a capillary. In the late 1980s and early 1990s, commercial capillary electrophoresis (CE) first became accessible. Mass spectrometry is a powerful tool for identifying unknowns, studying molecular structure, and investigating the fundamental principles of chemistry. The most efficient technique combines high-resolution sepa

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