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Relevant bibliographies by topics / Mass spectrometry / Dissertations / Theses

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Dissertations / Theses on the topic 'Mass spectrometry'

Author: Grafiati

Published: 4 June 2021

Last updated: 25 July 2025

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1

Lemire, Sharon Warford. "Rigorous analytical applications of liquid secondary ion mass spectrometry/mass spectrometry." Diss., Georgia Institute of Technology, 1996. http://hdl.handle.net/1853/30026.

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2

Dabney, David E. "Analysis of Synthetic Polymers by Mass Spectrometry and Tandem Mass Spectrometry." University of Akron / OhioLINK, 2009. http://rave.ohiolink.edu/etdc/view?acc_num=akron1259021862.

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3

Goodwin, Lee. "Capillary electrophoresis-mass spectrometry and tandem mass spectrometry studies of ionic agrochemicals." Thesis, University of York, 2003. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.398906.

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4

Shliaha, Pavel Vyacheslavovich. "Investigation of protein abundance and localization by mass spectrometry and ion-mobility spectrometry-mass spectrometry methods." Thesis, University of Cambridge, 2015. https://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.708661.

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5

Hsi, Kuang-Ying. "Peptide identification of tandem mass spectrometry from quadrupole time-of-flight mass spectrometers." Diss., [La Jolla] : University of California, San Diego, 2009. http://wwwlib.umi.com/cr/ucsd/fullcit?p1462246.

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Thesis (M.S.)--University of California, San Diego, 2009.<br>Title from first page of PDF file (viewed May 4, 2009). Available via ProQuest Digital Dissertations. Includes bibliographical references (p. 45-46).

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6

Yuen, Wei Hao. "Ion imaging mass spectrometry." Thesis, University of Oxford, 2012. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.564395.

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This work investigates the applicability of fast detectors to the technique of microscope-mode imaging mass spectrometry. By ionising analyte from a large area of the sample, and projecting the desorbed ions by the use of ion optics through a time-of-flight mass spectrometer onto a two- dimensional detector, time- (and hence mass-) dependent distributions of ions may be imaged. To date, this method of imaging mass spectrometry has been limited by the ability to image only one mass window of interest per experimental cycle, limiting throughput and processing speed. Thus, the alternative micropr

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7

Berezovskaya, Yana. "Investigation of protein-ion interactions by mass spectrometry and ion mobility mass spectrometry." Thesis, University of Edinburgh, 2012. http://hdl.handle.net/1842/7747.

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Protein‐ion interactions play an important role in biological systems. A considerable number of elements (estimated 25 – 30) are essential in higher life forms such as animals and humans, where they are integral part of enzymes involved in plethora of cellular processes. It is difficult to overestimate the importance of thorough understanding of how protein‐ion interplay affects living cell in order to be able to address therapeutic challenges facing humanity. Presented to the reader’s attention is a gas‐phase biophysical analysis of peptides’ and proteins’ interactions with biologically relev

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8

Liu, Xiumin. "Mass Spectrometry and Tandem Mass Spectrometry Analysis of Polymers and Polymer-Protein Interactions." University of Akron / OhioLINK, 2014. http://rave.ohiolink.edu/etdc/view?acc_num=akron1406838246.

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9

Kaleta, Erin. "Applications of mass spectrometry to bacterial diagnostics: Affinity capture matrix assisted laser desorption/ionization mass spectrometry and polymerase chain reaction mass spectrometry." Diss., The University of Arizona, 2011. http://hdl.handle.net/10150/305352.

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This dissertation presents the application of mass spectrometry to the detection and characterization of microorganisms based on biomarker identification and DNA analysis. Two major topics are covered: affinity capture mass spectrometry using immunoassay methods and methods involving insertion of membrane receptors into polymerized planar supported lipid bilayers; and the application of mass spectrometry for use in clinical microbiology for the identification of microorganisms causing bloodstream infections. Affinity capture mass spectrometry on immunoassay-based platforms studied the captu

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10

Sun, Xiaobo. "Forensic Applications of Gas Chromatography/Mass Spectrometry, High Performance Liquid Chromatography--Mass Spectrometry and Desorption Electrospray Ionization Mass Spectrometry with Chemometric Analysis." Ohio University / OhioLINK, 2012. http://rave.ohiolink.edu/etdc/view?acc_num=ohiou1329517616.

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11

Woods, Lucy Ann. "Characterising amyloid assembly using ion mobility spectrometry-mass spectrometry." Thesis, University of Leeds, 2012. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.590277.

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From small molecules to macromolecules, mass spectrometry has evolved significantly over the past decade, progressing from a tool to identify chemical elements to a powerful technique able to elucidate structural information for large protein complexes. With the interfacing of ion mobility spectrometry to mass spectrometry (IMS-MS), mass spectrometric analyses now occupy an extra dimension, providing unrivalled separation and structural characterisation of lowly-populated species in heterogeneous mixtures. One biological system that has benefitted enormously from such advances is the study of

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12

Zhou, Yi. "Microfluidics interfacing to mass spectrometry." College Park, Md. : University of Maryland, 2007. http://hdl.handle.net/1903/7402.

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Thesis (Ph. D.) -- University of Maryland, College Park, 2007.<br>Thesis research directed by: Mechanical Engineering. Title from t.p. of PDF. Includes bibliographical references. Published by UMI Dissertation Services, Ann Arbor, Mich. Also available in paper.

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13

Testino, Samuel A. Jr. "Optimization strategies in mass spectrometry." Thesis, Georgia Institute of Technology, 1994. http://hdl.handle.net/1853/26972.

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14

Rostom, Adam A. "Mass spectrometry of protein interactions." Thesis, University of Oxford, 1999. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.312385.

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15

Winter, David. "Drug analysis by mass spectrometry." Thesis, University of Canterbury. Chemistry, 1986. http://hdl.handle.net/10092/6560.

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1. The pharmacokinetics of morphine have been measured in four patients with renal failure and three healthy volunteers following intramuscular administration of papaveretum. Morphine blood levels were determined using GCMS with specific ion monitoring. The significantly shorter drug elimination half-life found for the patients suggests that renal failure does not impair the elimination of morphine. 2. A CI GCMS assay with specific ion monitoring has been developed for measuring the anti parkinsonian drug benztropine in post-mortem specimens. The assay is potentially more sensitive than a sim

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16

Perkins, John Robert. "Supercritical fluid chromatography/mass spectrometry." Thesis, Cardiff University, 1989. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.375969.

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17

Smith, Derek John. "Femtosecond Laser Mass Spectrometry (FLMS)." Thesis, University of Glasgow, 1998. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.264149.

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18

Sweet, Steve M. M. "Phosphoprotein analysis by mass spectrometry." Thesis, University of Manchester, 2005. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.538385.

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19

Cobice, Diego Federico. "Mass spectrometry imaging of steroids." Thesis, University of Edinburgh, 2015. http://hdl.handle.net/1842/21032.

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Glucocorticoids are steroid hormones involved in the stress response, with a well-established role in promoting cardiovascular risk factors including obesity and diabetes. The focus of glucocorticoid research has shifted from understanding control of blood levels, to understanding the factors that control tissue steroid concentrations available for receptor activation; it is disruption of these tissue-specific factors that has emerged as underpinning pathophysiological mechanisms in cardiovascular risk, and revealed potential therapeutic targets. However, the field is hampered by the inability

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20

Salter, Tara La Roche. "Metrology for ambient mass spectrometry." Thesis, University of Nottingham, 2015. http://eprints.nottingham.ac.uk/28748/.

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Ambient mass spectrometry (AMS) is a new and versatile method for analysing a multitude of different sample types with the benefit of analysis at ambient pressure and the many other advantages that this entails. However, as these techniques are still in their infancy, metrological development of the techniques is essential. This is a critical step before AMS can be used reliably in the application areas in which it has shown great promise. The research in this thesis addresses the development of AMS sources, in particular plasma-assisted desorption-ionisation, PADI. Optimisation and characteri

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21

McClure, Thomas Dale. "Biomedical applications of mass spectrometry." Diss., The University of Arizona, 1991. http://hdl.handle.net/10150/185490.

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The application of mass spectrometry to verification of the structure of 3-methyluridine (m³U) isolated by HPLC from normal human urine is described. m³U has been used as an internal standard for studies of urinary nucleosides, a practice that is discouraged with the confirmation of m³U as a naturally occurring compound. Mass spectrometry has been used for the identification of 5'-deoxyxanthosine (5'-dX) a novel nucleoside in normal human urine. Initial concern over availability of a reference sample of 5'-dX prompted investigations of the structure/fragmentation relationships of the TMS derat

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22

Offei, Felix. "Denoising Tandem Mass Spectrometry Data." Digital Commons @ East Tennessee State University, 2017. https://dc.etsu.edu/etd/3218.

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Protein identification using tandem mass spectrometry (MS/MS) has proven to be an effective way to identify proteins in a biological sample. An observed spectrum is constructed from the data produced by the tandem mass spectrometer. A protein can be identified if the observed spectrum aligns with the theoretical spectrum. However, data generated by the tandem mass spectrometer are affected by errors thus making protein identification challenging in the field of proteomics. Some of these errors include wrong calibration of the instrument, instrument distortion and noise. In this thesis, we pres

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23

SPEZZANO, ROBERTO. "Lipids and Mass Spectrometry Application." Doctoral thesis, Università degli Studi di Milano, 2019. http://hdl.handle.net/2434/647470.

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During my PhD courses I focused attention on the applications of mass spectrometry in lipidomic studies. I applied mass spectrometry in several experimental models to try to observe differences in selected metabolites affected by a particular pathology. The first project performed in experimental model of impaird lipogenesis highlighted a cross talk between altered fatty acid synthesis and neuroactive steroid levels. The second project, mass spectrometry application allows to understand he effect of short-term diabetes on cholesterol metabolism. In the last project lipidomic pattern was i

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24

Mohan, Krishnan R. "Fast atom bombardment mass spectrometry and tandem mass spectrometry : conditions for measurement of reproducible spectra." Thesis, Georgia Institute of Technology, 1993. http://hdl.handle.net/1853/27159.

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25

Catron, Brittany Lyn. "Analysis of Protein:RNA Cross-links by Inductively Coupled Plasma Mass Spectrometry and Tandem Mass Spectrometry." University of Cincinnati / OhioLINK, 2012. http://rave.ohiolink.edu/etdc/view?acc_num=ucin1337885809.

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26

Crnogorac, Goranka. "Analysis of dithiocarbamate fungicide residues by liquid chromatography, mass spectrometry and isotope ratio mass spectrometry." Aachen Shaker, 2008. http://d-nb.info/993691447/04.

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27

Zhou, Li. "Enhanced Electrospray Ionization for Mass Spectrometry and Ion Mobility Spectrometry." Diss., CLICK HERE for online access, 2006. http://contentdm.lib.byu.edu/ETD/image/etd1384.pdf.

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28

Cunningham, Connell Glish Gary L. "Improved methods of tandem mass spectrometry for proteomics applications in a quadrupole ion trap mass spectrometer." Chapel Hill, N.C. : University of North Carolina at Chapel Hill, 2006. http://dc.lib.unc.edu/u?/etd,217.

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Thesis (Ph. D.)--University of North Carolina at Chapel Hill, 2006.<br>Title from electronic title page (viewed Oct. 10, 2007). " ... in partial fulfillment of the requirements for the degree of Doctor of Philosophy in the Department of Chemistry. Chapel Hill 2006." Discipline: Chemistry; Department/School: Chemistry.

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29

Perdian, David C. "Direct analysis of samples by mass spectrometry from elements to bio-molecules using laser ablation inductively coupled plasma mass spectrometry and laser desorption/ionization mass spectrometry /." [Ames, Iowa : Iowa State University], 2009. http://gateway.proquest.com/openurl?url_ver=Z39.88-2004&rft_val_fmt=info:ofi/fmt:kev:mtx:dissertation&res_dat=xri:pqdiss&rft_dat=xri:pqdiss:3369879.

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30

Göth, Melanie [Verfasser]. "Investigation of Protein-Ligand Complexes by Native Mass Spectrometry and Ion Mobility-Mass Spectrometry / Melanie Göth." Berlin : Freie Universität Berlin, 2017. http://d-nb.info/1149050594/34.

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31

Martin, Nicholas Joseph. "Surface analysis for proteomics via liquid extraction surface analysis mass spectrometry and liquid chromatography mass spectrometry." Thesis, University of Birmingham, 2016. http://etheses.bham.ac.uk//id/eprint/6493/.

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Liquid extraction surface analysis (LESA) is an ambient ionisation technique which allows direct analysis of surfaces coupled with mass spectrometry. LESA mass spectrometry has been used successfully to analyse small molecules, but there are a limited number of examples where the approach has been applied to protein analysis. The work presented here aims to develop novel applications of LESA mass spectrometry of proteins. LESA mass spectrometry was used to analyse intact proteins from polymeric membranes. The rationale for these experiments was the potential application to analyse proteins ele

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32

Galezowska, Angelika. "Rapid characterisation of quinazoline drug impurities using electrospray mass spectrometry-mass spectrometry and computational chemistry approaches." Thesis, University of Southampton, 2011. https://eprints.soton.ac.uk/300028/.

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Structural characterisation of impurities from synthetic pathways of drugs is an important process in pharmaceutical development. Dissociation pathways of the impurities can vary between different classes of compounds, often resulting in a challenging and a time-consuming process of data interpretation. A detailed understanding of the specific structural features of the fragmentation behaviour of impurity gas-phase ions affords faster characterisation of the unknown sub-structures. Establishing electrospray ionisation-tandem mass spectrometry (ESI-MS/MS) fragmentation rules, based on structure

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33

John, Gareth David. "Secondary ion mass spectrometry and resonant ionisation mass spectrometry studies of nickel contacts to silicon carbide." Thesis, Swansea University, 2004. https://cronfa.swan.ac.uk/Record/cronfa42495.

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Time-of-flight secondary ion mass spectrometry (TOF-SIMS) and resonant ionisation mass spectrometry (RIMS) have been used to perform depth profile analyses on nickel (Ni) contacts to silicon carbide (SiC) to understand the interfacial properties. In particular, as-deposited Schottky contacts and high temperature annealed Ohmic contacts have been characterised. Previous literature had indicated that the chemistry of the interface controlled the electrical properties of the contact. Using the TOF-SIMS system, depth profiles have been performed with the standard duoplasmatron ion source and a new

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34

Zoppi, Ugo. "Isobar suppression in accelerator mass spectrometry /." [S.l.] : [s.n.], 1993. http://e-collection.ethbib.ethz.ch/show?type=diss&nr=10373.

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35

Bundala, Matthew Matus. "Serological immune profiling using mass spectrometry." Thesis, University of British Columbia, 2017. http://hdl.handle.net/2429/63765.

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The adaptive immune system is a fantastically complex system comprised of specialized cells, organs and molecules. When properly functioning, our adaptive immune system is continually responding to, and protecting us from, a myriad of disease threats ranging from viruses to cancer. Immune dysfunction leaves us vulnerable to pathogens and can result in autoimmune disorders. Despite the adaptive immune system’s central importance in health, efficient immune profiling methods, and in particular approaches capable of functional characterization of adaptive immune responses, are still in their infa

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36

Mironov, Gleb. "Capillary Electrophoresis - Mass Spectrometry for Bioanalysis." Thesis, Université d'Ottawa / University of Ottawa, 2015. http://hdl.handle.net/10393/33004.

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Bioanalysis is a subdivision of analytical chemistry and deals with biological analytes such as metabolites, proteins, nucleic acids, small molecules, virus particles and entire cells. The rationale of my thesis was to achieve two goals: (i) develop a set of ready to use methods (ii) which are capable providing exact concentrations of analytes as well as kinetic and thermodynamic parameters of their interactions. To investigate interactions between biomolecules special conditions are required which do not interfere with the course if biomolecule interactions. Establishing these conditions and

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37

Jonsson, Andreas. "Mass spectrometry in protein structure analysis /." Stockholm, 2001. http://diss.kib.ki.se/2001/91-628-4716-3/.

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38

Nelson, Paul Redfield. "Applications of analytical collisional mass spectrometry." Diss., Georgia Institute of Technology, 1987. http://hdl.handle.net/1853/27053.

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39

Mullis, James Onis Jr. "Planar chromatography coupled with mass spectrometry." Thesis, Georgia Institute of Technology, 1992. http://hdl.handle.net/1853/27124.

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40

Ho, Stacy Zhanying. "Aerosol sample introduction and mass spectrometry." Diss., Georgia Institute of Technology, 1997. http://hdl.handle.net/1853/30517.

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41

Axford, Stephen Douglas Tabrum. "Mass spectrometry of ions in flames." Thesis, University of Cambridge, 1991. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.239584.

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42

Nettleton, Ewan John. "Analysing protein conformations by mass spectrometry." Thesis, University of Oxford, 1998. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.298392.

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43

Florane, H. "Exploring protein conformation with mass spectrometry." Thesis, University of Edinburgh, 2008. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.650980.

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The first part of this thesis describes the development and viability of a phase I screening system for obtaining a rank order of affinity of novel ligands against the immunophilin, Cyclophilin A (CypA). The naturally occurring inhibitor Cyclosporin A (CsA) was used as a positive control to validate a method for calculating the dissociation constant (K<sub>d</sub>). An HPLC autosampler and pumping system was used as a high throughput on-line electrospray ionisation (ESI)-MS sampling system. Optimised ESI conditions were then used to screen novel ligands from 3 combinatorial libraries and appro

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44

Ben-Farag, Suaad Omran S. "Statistical analysis of mass spectrometry data." Thesis, University of Leeds, 2013. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.659026.

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The research described in this thesis can be broadly described by term "statistical analysis of mass spectrometry data". Bioinformatics is a new science which attempts to amalgamate statistical methodology with bring statistical thinking and the biological understanding to area which have previously been void of such. Mass spectrometry which is used to study proteins and their functions, is a relatively new field of bioinformatics research. In this thesis we explore three main themes, all of which tackle a different statistical learning method which arises in mass spectrometry. The main focus

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45

Jackson, Anthony Trevor. "Tandem mass spectrometry of polymeric materials." Thesis, University of Warwick, 1995. http://wrap.warwick.ac.uk/44296/.

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Mass spectrometry and tandem mass spectrometry (MS/MS) has been employed to analyse peptides (<600 daltons), synthetic polymers of low molecular weight (<10,000 daltons) and a mixture of polymer additives (300-1200 daltons). Mass spectrometry experiments were performed on a four sector mass spectrometer, a tandem quadrupole mass spectrometer and a time-of-flight instrument. High and low energy collision induced dissociation (CID) spectra were obtained by means of a four sector mass spectrometer and a tandem quadrupole instrument respectively. Surface induced dissociation (SID) spectra of pepti

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46

O'Neill, Karen Elizabeth. "Studies in ion trap mass spectrometry." Thesis, University of East Anglia, 1992. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.332326.

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47

Clinton, Rebecca. "Pharmaceutical process analysis by mass spectrometry." Thesis, Nottingham Trent University, 2005. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.430266.

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48

Ponce, Alquicira Edith. "Food analyzing using electrospray mass spectrometry." Thesis, University of Nottingham, 1995. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.324538.

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49

Owen, Andrew. "Direct liquid sampling process mass spectrometry." Thesis, University of Strathclyde, 2006. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.431825.

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50

Dumville, Joanne. "Developments in laser-microprobe mass-spectrometry." Thesis, University of Cambridge, 1994. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.360826.

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