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1

Ridley, S. "Critical Care Handbook of the Massachussetts General Hospital (5th edn)." Anaesthesia 65, no. 7 (April 8, 2010): 762–63. http://dx.doi.org/10.1111/j.1365-2044.2010.06345.x.

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&NA;. "Beth Israel Hospital Boston." American Journal of Nursing 96 (January 1996): 41. http://dx.doi.org/10.1097/00000446-199601001-00014.

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Ives Erickson, Jeanette, Michael Allard, Bonnie Blanchfield, John A. Hammond, Gregg S. Meyer, Giles W. Boland, and Craig Vanderwagen. "Field Hospital Boston Hope." Nursing Administration Quarterly 45, no. 2 (February 5, 2021): 102–8. http://dx.doi.org/10.1097/naq.0000000000000462.

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Gooding, Holly C., Caitlin McCarty, Rebecca Millson, Hungyu Jiang, Elizabeth Armstrong, and Alan M. Leichtner. "The Boston Children’s Hospital Academy." Academic Medicine 91, no. 12 (December 2016): 1651–54. http://dx.doi.org/10.1097/acm.0000000000001095.

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Mayer, John E., and Pedro J. del Nido. "Boston Children׳s Hospital Cardiovascular Program." Seminars in Thoracic and Cardiovascular Surgery 28, no. 3 (2016): 621–25. http://dx.doi.org/10.1053/j.semtcvs.2016.10.010.

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Warshaw, Andrew L. "Department of Surgery, Massachusetts General Hospital, Boston." Archives of Surgery 138, no. 11 (November 1, 2003): 1173. http://dx.doi.org/10.1001/archsurg.138.11.1173.

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7

&NA;. "The Childrenʼs Hospital, Boston Performance criteria." Nursing Administration Quarterly 12, no. 2 (1988): 58–62. http://dx.doi.org/10.1097/00006216-198801220-00010.

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8

Connor, Jean A., Sandra Mott, Michele DeGrazia, Debra Lajoie, Patricia Dwyer, Mary Poyner Reed, Courtney Porter, and Patricia A. Hickey. "Nursing science fellowship at Boston Children's Hospital." Applied Nursing Research 55 (October 2020): 151292. http://dx.doi.org/10.1016/j.apnr.2020.151292.

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Warshaw, A. L., D. W. Rattner, and C. Fernandez del Castillo. "3. HPB Surgery at Massachusetts General Hospital, Boston, USA." HPB 1, no. 4 (1999): 221–22. http://dx.doi.org/10.1016/s1365-182x(17)30674-3.

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Bahren, Mary Beth. "ON THE SCENE: At Beth Israel Hospital, Boston." Nursing Administration Quarterly 18, no. 4 (1994): 10–37. http://dx.doi.org/10.1097/00006216-199401840-00005.

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Rempusheski, Veronica F., and Susan L. Chamberlain. "Nursing Research Image at Beth Israel Hospital, Boston." JONA: The Journal of Nursing Administration 19, no. 10 (October 1989): 6???7. http://dx.doi.org/10.1097/00005110-198910010-00003.

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Griscom, N. T., and R. L. Teele. "Radiology at Children's Hospital in Boston: a history." American Journal of Roentgenology 161, no. 4 (October 1993): 887–91. http://dx.doi.org/10.2214/ajr.161.4.8372782.

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Eggertson, L. "Canadian doctor led bombing response at a Boston hospital." Canadian Medical Association Journal 185, no. 9 (April 22, 2013): E373—E374. http://dx.doi.org/10.1503/cmaj.109-4471.

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14

Sabbath, Erika L., Dean Hashimoto, Leslie I. Boden, Jack T. Dennerlein, Jessica A. R. Williams, Karen Hopcia, Theresa Orechia, Yorghos Tripodis, Anne Stoddard, and Glorian Sorensen. "Cohort profile: The Boston Hospital Workers Health Study (BHWHS)." International Journal of Epidemiology 47, no. 6 (August 10, 2018): 1739–40. http://dx.doi.org/10.1093/ije/dyy164.

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CHAN, A. "Closing of the service at boston city hospital: Another perspective." Journal of Nurse-Midwifery 34, no. 2 (March 1989): 95–96. http://dx.doi.org/10.1016/0091-2182(89)90036-0.

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16

Haridas, Rajesh P., and Jeffrey A. Mifflin. "Researches Regarding the Morton Ether Inhaler at Massachusetts General Hospital, Boston." Anesthesia & Analgesia 117, no. 5 (November 2013): 1230–35. http://dx.doi.org/10.1213/ane.0b013e31829cc6d2.

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Hunt, Valerie, and Elaine Waudby. "The Nursing Research Model at St. Elizabeth??s Hospital, Boston." JONA: The Journal of Nursing Administration 20, no. 10 (October 1990): 4???5. http://dx.doi.org/10.1097/00005110-199010000-00002.

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18

Maas, Joyce, Ger P. J. Keijsers, Mike Rinck, and Eni S. Becker. "Does Cognitive Bias Modification Prior to Standard Brief Cognitive Behavior Therapy Reduce Relapse Rates in Hair Pulling Disorder? A Double-Blind Randomized Controlled Trial." Journal of Social and Clinical Psychology 37, no. 6 (June 2018): 453–79. http://dx.doi.org/10.1521/jscp.2018.37.6.453.

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Background: In line with previous research in alcohol addiction, we tested whether an Approach-Avoidance Training (AAT) prior to standard six-session Cognitive Behavior Therapy (CBT) for Hair Pulling Disorder (HPD) reduced problematic relapse, commonly found in this population. Method: Prior to CBT, 54 outpatients with a primary diagnosis of HPD were randomly assigned (double-blind) to either a training condition (n = 27), learning to avoid hair-pulling-related stimuli, or to a control condition (n = 27). Symptom severity was assessed with the Massachussetts General Hospital Hairpulling Scale, Severity Urge Resistance Frequency Scale, Self-Control Cognition Questionnaire, and Alopecia Scale. Results: In line with existing research, CBT showed to be an effective treatment for HPD in the short-term. There was no significant symptom increase after one and three months, but effect sizes were reduced approximately by half at the twelve-month measurement. The AAT training prior to CBT did not result in enhanced symptom reduction or reduced relapse after CBT. Conclusions: AAT training could not resolve the substantial relapse after successful CBT. Future research should take into account the complexity of stimuli that elicit hair pulling (e.g., tactile stimuli) and consider investigating other types of biases.
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Hague, Ashley Clare. "Recent Developments in Health Law: Civil Procedure: First Circuit Holds it Unreasonable to Hale Hospitals into Foreign Forums Simply for Accepting Out-of-State Patients — Harlow v. Children's Hospital." Journal of Law, Medicine & Ethics 34, no. 2 (2006): 467–69. http://dx.doi.org/10.1111/j.1748-720x.2006.00054.x.

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The United States Court of Appeals for the First Circuit recently upheld a United States District Court for the District of Maine Judge's decision to dismiss a Maine plaintiff's medical malpractice claim against a Massachusetts hospital defendant for want of personal jurisdiction over the hospital. The Court of Appeals found it unreasonable to hale hospitals into an out-of-state court merely because they accept out-of-state patients.Plaintiff Danielle Harlow is a Maine resident who suffered a stroke at the age of six while undergoing a medical procedure at Children's Hospital of Boston, Massachusetts (“Children's Hospital”). The stroke, allegedly caused by the Hospital's negligence, led to brain damage resulting in partial paralysis and cognitive and behavioral impairments. The procedure was supposed to treat Harlow's rapid heartbeat, a condition related to her Wolff-Parkinson-White Syndrome. Harlow's pediatrician in Maine recommended that she visit Children's Hospital in Boston to treat her arrhythmia.
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Millet, E., R. Icick, and J. P. Lépine. "Treatment-resistant depression: From pseudo-resistance to full resistance." European Psychiatry 26, S2 (March 2011): 638. http://dx.doi.org/10.1016/s0924-9338(11)72344-6.

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IntroductionTreatment-resistant depression (TRD) has been a controversial issue for more than 35 years. Despite a large number of publications, clinicians and researchers still know few about the prevalence of TRD since no staging method has been validated.ObjectivesWe sought to assess similarities and differences between the 4 TRD-staging methods published to date and assess TRD prevalence in a clinical sample. We also wanted to look for clinical factors associated with TRD.MethodsWe conducted a clinical study in a psychiatric unit of a university hospital. We designed a hetero-questionnaire to stage TRD according to the 4 methods. Psychiatric diagnosis, depression severity and cognitive status were assessed using standardized tools. Patients were not included in the study if they suffer from schizophrenia, bipolar disorder, current substance dependence or major cognitive impairment.ResultsWe recruited 37 inpatients. Twenty-four had received an inadequate treatment, four had not responded after one adequate antidepressant trial and 9 after two trials. Only 7 were resistant according to the 4 staging methods, which showed several differences. The Massachussetts General Hospital (MGH) method appeared as the most specific and easy-to-use. Complete TRD seemed much less frequent than pseudo-resistance and relative resistance with untreated comorbidity. Chronic depression and comorbidity were frequent in the TRD subgroup.ConclusionThe concept of “difficult-to-treat” depression might be more appropriate for clinical practice than TRD. The MGH tool seems to fit best to clinical practice. Further research is needed to confirm these descriptive findings in a larger sample.
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Sloan, Steven R. "Transfusions for patients with sickle cell disease at Children's Hospital Boston." Immunohematology 28, no. 1 (2019): 17–19. http://dx.doi.org/10.21307/immunohematology-2019-143.

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22

Wennberg, JohnE, JeanL Freeman, and WilliamJ Culp. "ARE HOSPITAL SERVICES RATIONED IN NEW HAVEN OR OVER-UTILISED IN BOSTON?" Lancet 329, no. 8543 (May 1987): 1185–89. http://dx.doi.org/10.1016/s0140-6736(87)92152-0.

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23

Wennberg, John E., Jean L. Freeman, Roxanne M. Shelton, and Thomas A. Bubolz. "Hospital Use and Mortality among Medicare Beneficiaries in Boston and New Haven." New England Journal of Medicine 321, no. 17 (October 26, 1989): 1168–73. http://dx.doi.org/10.1056/nejm198910263211706.

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24

Bonkhoff, Anna. "Vorhersage der Funktionserholung nach Schlaganfall basierend auf multimodaler zerebraler MRT-Bildgebung." Klinische Neurophysiologie 52, no. 02 (May 27, 2021): 118–19. http://dx.doi.org/10.1055/a-1468-7698.

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25

Crockett, Dennis M., Trevor J. McGill, Gerald B. Healy, and Ellen M. Friedman. "Airway Management of Acute Supraglottitis at the Children's Hospital, Boston: 1980–1985." Annals of Otology, Rhinology & Laryngology 97, no. 2 (March 1988): 114–19. http://dx.doi.org/10.1177/000348948809700203.

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A controversy has existed in recent years regarding the ideal method of establishing and maintaining an airway in the pediatric patient with acute supraglottitis. Nasotracheal intubation has been used as the sole method of airway management of acute supraglottitis at The Children's Hospital, Boston, since 1970. This paper reviews our experience with 80 children with acute supraglottitis presenting at our institution during the years 1980 to 1985.
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26

Vilensky, Joel A., Sid Gilman, and Pandy R. Sinish. "Denny-Brown, Boston City Hospital, and the History of American Neurology." Perspectives in Biology and Medicine 47, no. 4 (2004): 505–18. http://dx.doi.org/10.1353/pbm.2004.0074.

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27

Gross, Bradley A., Armide Storey, Darren B. Orbach, R. Michael Scott, and Edward R. Smith. "Microsurgical treatment of arteriovenous malformations in pediatric patients: the Boston Children's Hospital experience." Journal of Neurosurgery: Pediatrics 15, no. 1 (January 2015): 71–77. http://dx.doi.org/10.3171/2014.9.peds146.

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OBJECT Outcomes of microsurgical treatment of arteriovenous malformations (AVMs) in children are infrequently reported across large cohorts. METHODS The authors undertook a retrospective review of departmental and hospital databases to obtain the medical data of all patients up to 18 years of age who were diagnosed with cerebral AVMs. Demographic and AVM angioarchitectural characteristics were analyzed, and for the patients who underwent surgery, the authors also analyzed the estimated intraoperative blood loss, postoperative angiographically confirmed obliteration rates, and neurological complications and outcomes classified according to the modified Rankin Scale (mRS). RESULTS Of 117 children with cerebral AVMs, 94 underwent microsurgical resection (80%). Twenty (21%) of these 94 patients underwent adjunctive preoperative embolization. The overall postoperative angiographically confirmed obliteration rate was 94%. As part of a new protocol, the last 50 patients in this series underwent immediate perioperative angiography, improving the subsequent obliteration rate from 86% to 100% (p = 0.01). No other factors, such as a hemorrhagic AVM, size of the AVM, location, drainage, or Spetzler-Martin grade, had a statistically significant impact on the obliteration rate. Perioperative neurological deficits occurred in 17% of the patients, but the vast majority of these (77%) were predictable visual field cuts. Arteriovenous malformations that were hemorrhagic or located in noneloquent regions were each associated with lower rates of postoperative neurological complications (p = 0.05 and 0.002, respectively). In total, 94% of the children had good functional outcomes (mRS Scores 0–2), and these outcomes were significantly influenced by the mRS score on presentation before surgery (p = 0.01). A review of 1- and 5-year follow-up data indicated an overall annual hemorrhage rate of 0.3% and a recurrence rate of 0.9%. CONCLUSIONS Microsurgical resection of AVMs in children is associated with high rates of angiographically confirmed obliteration and low rates of significant neurological complications. Implementation of a protocol using perioperative angiography in this series led to complete radiographically confirmed obliteration of all AVMs, with low annual repeat hemorrhage and recurrence rates.
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Zenonos, Georgios, Osama Jamil, Lance S. Governale, Sarah Jernigan, Daniel Hedequist, and Mark R. Proctor. "Surgical treatment for primary spinal aneurysmal bone cysts: experience from Children's Hospital Boston." Journal of Neurosurgery: Pediatrics 9, no. 3 (March 2012): 305–15. http://dx.doi.org/10.3171/2011.12.peds11253.

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Object Spinal aneurysmal bone cysts (ABCs) constitute a rare and clinically challenging disease, primarily affecting the pediatric population. Information regarding the management of spinal ABCs remains sparse. In this study the authors review their experience with spinal ABCs at Children's Hospital Boston. Methods The medical records of all patients treated surgically for primary spinal ABCs between January 1998 and July 2010 were retrospectively reviewed. Results Fourteen cases were identified (6 males and 8 females, ages 5–19 years old). The ABCs were located throughout the spine, with an equal number in the thoracic and lumbar spine, and rarely in the cervical spine. The majority of patients presented with back pain, but neurological deficits and spinal deformity were common. A variety of radiographic techniques were used to establish the diagnosis, including needle biopsy. Preoperative selective arterial embolization was performed in 7 cases (50%), and the majority of cases required spinal instrumentation along with resection. Mean follow-up was 55.9 months (range 15–154 months) after initial intervention. Two ABCs recurred (14%), at 9 months and 8 years after incomplete initial resection, and the patients underwent reoperation. Complete resection was ultimately achieved in all cases. All patients were asymptomatic and neurologically intact at their last follow-up evaluation, and showed no evidence of deformity or recurrence on imaging. Conclusions Computed tomography and MR imaging are adequate for an initial evaluation of spinal ABCs, although solid variants can present a diagnostic challenge. Given the high rates of recurrence with residual disease, complete obliteration of the lesion should be the goal of treatment. Preoperative embolization is often performed, although in the authors' opinion the degree of bleeding tends not to support its routine use. Long-term follow-up is warranted as recurrences can occur years after initial intervention. However, gross-total excision in conjunction with spinal stabilization, as needed, usually provides cure of the ABC and excellent long-term spinal alignment.
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Angel, Jonathan B. "HIV Cure Research: An example of successful advocacy by scientists for science." Clinical and Investigative Medicine 41 (November 3, 2018): 14–16. http://dx.doi.org/10.25011/cim.v41i2.31416.

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Following medical school and an internal medicine residency in Toronto, and infec-tious diseases training at the New England Medical Center/Tufts University in Boston, Jonathan joined the Division of Infectious Diseases, Department of Medicine at the Ottawa General Hospital in 1995. His research focuses on understanding how HIV damages the immune system and how these insights may lead to new therapies. Jon-athan is currently Professor of Medicine, University of Ottawa and Senior Scientist, Ottawa Hospital Research Institute. He was Editor-in-Chief of CIM from 2010–2015.
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Weissman, J. "Case mix and resource utilization by uninsured hospital patients in the Boston metropolitan area." JAMA: The Journal of the American Medical Association 261, no. 24 (June 23, 1989): 3572–76. http://dx.doi.org/10.1001/jama.261.24.3572.

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Elliott, Martin. "Seeing Through the Lies: Surgical Innovation and the Need for Transparency." World Journal for Pediatric and Congenital Heart Surgery 8, no. 4 (July 2017): 520–26. http://dx.doi.org/10.1177/2150135117717975.

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The Robert E Gross Lecture was delivered by Professor Martin Elliott of London, at Boston Children’s Hospital June 1st, 2016. Professor Elliott makes a plea for revision to the system of medical publication and academic reward, especially in the field of surgery.
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Taran, Shaurya, Benjamin Chin-Yee, and Allan S. Detsky. "Night Call in a Teaching Hospital: 1979 and 2019." Journal of Hospital Medicine 14, no. 12 (August 21, 2019): 782–84. http://dx.doi.org/10.12788/jhm.3284.

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No matter the era, few aspects of residency are more defining or memorable than overnight call. Nights can be a time of growth and learning but also of fear and uncertainty, as residents take on the responsibility of managing sick patients on their own. One of us (ASD) started his residency in 1978 at the Massachusetts General Hospital in Boston; the other two (ST and BCY) started theirs in 2016 and 2017, respectively, at the University of Toronto. In this essay, we reflect on our experiences of night call separated by 40 years, highlighting what has changed and what has stayed the same.
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Shukl, Vaissnavi, and Sukumar P. Desai. "Bulfinch and the Massachusetts General Hospital: History at the Intersection of Architecture and Medicine." Journal of Surgery & Transplantation Science 10, no. 1 (November 30, 2023): 1–5. http://dx.doi.org/10.47739/2379-0911.surgery.1089.

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Albeit never trained in architectural design, Charles Bulfinch (1763-1844) is widely recollected as the first native-born American to practice architecture professionally. Inspired by continental influences, Bulfinch developed the neoclassicist style reflected in major private and public structures in Boston and Washington D.C. Although we have numerous studies of Bulfinch’s fascinating and pioneering architectural career, less is known about his intimate relationship to the medical field. Bulfinch was the chief designer of Massachusetts General Hospital, America’s third-oldest general hospital and Harvard Medical School’s first teaching hospital. Drawing on a wide range of underexplored primary and secondary sources, this article offers a historical recounting of Bulfinch’s life and architectural trajectory up to the conception and design of Massachusetts General Hospital. Then, it draws attention to the structure and organization of the Hospital, its position within the historical context of the time, and its lasting impact on the history of American medicine. In so doing, this article provides a fresh perspective into Boston’s healthcare architecture, the history of its preeminent hospital, and the legendary personality that made it what it is today
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Puri, A., E. Smith, M. Scott, and D. Orbach. "O-007 Treatment of pial arteriovenous malformations: single institution experience at Children's hospital boston." Journal of NeuroInterventional Surgery 2, Suppl_1 (July 1, 2010): A3—A4. http://dx.doi.org/10.1136/jnis.2010.003244.7.

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Tretter, Justin T., and Jeffrey P. Jacobs. "Global Leadership in Paediatric and Congenital Cardiac Care: “Following the ‘Golden Rule’ in multicentre collaborations – an interview with Jane W. Newburger, MD”." Cardiology in the Young 30, no. 9 (August 6, 2020): 1221–25. http://dx.doi.org/10.1017/s1047951120002267.

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AbstractDr. Jane Newburger is the focus of our first in a planned series of interviews in Cardiology in the Young entitled, “Global Leadership in Paediatric and Congenital Cardiac Care”. Dr. Newburger was born in Manhattan, New York, United States of America. She was raised in the Bronx for her first six years of life, at which point her family moved to Yonkers, New York, where she spent the rest of her childhood. She then attended Bryn Mawr College where she majored in psychology. Dr. Newburger subsequently attended Harvard Medical School, graduating in 1974. She did her internship and residency in paediatrics at Boston Children’s Hospital in 1974–1976, followed by her fellowship at Boston Children’s Hospital in 1976–1979. She received her Masters in Public Health at the Harvard School of Public Health in 1980.Dr. Newburger has spent her entire career as a paediatric cardiologist at Boston Children’s Hospital and Harvard Medical School, where she was appointed a Professor of Pediatrics in 1999 and has held the position as Commonwealth Professor of Pediatrics since 2008. She has established herself as a leading clinical scientist within the field of paediatric cardiology, with expertise in leadership of multicentre and multidisciplinary research, including the building of collaborative groups. She has been continuously funded by the National Institute of Health since 1982, and amongst other areas has led the field in the areas of neurodevelopmental outcomes in congenital heart disease, improved methods of vital organ support, and management of Kawasaki disease. This article presents our interview with Dr. Newburger, an interview that covers her path towards becoming a clinical scientist, her interests spanning four decades of hard work, and her strategies to design and lead successful multicentre studies.
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Haridas, Rajesh P. "Horace Wells’ Demonstration of Nitrous Oxide in Boston." Anesthesiology 119, no. 5 (November 1, 2013): 1014–22. http://dx.doi.org/10.1097/aln.0b013e3182a771ea.

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Abstract Horace Wells, a dentist in Hartford, Connecticut, first used nitrous oxide in dentistry in December 1844. A few weeks later he travelled to Boston, Massachusetts, to demonstrate to physicians and dentists the use of nitrous oxide in painful procedures. Wells’ unsuccessful demonstration of nitrous oxide for the extraction of a tooth is well known, but other details of this trip are poorly understood. A description of Wells’ visit to Boston was compiled using information from 21 statements and 5 newspaper notices. The precise date and location of Wells’ demonstration could not be determined. There is no primary evidence that Wells’ demonstration occurred in the surgical amphitheater (Ether Dome) at Massachusetts General Hospital. Wells’ demonstration of nitrous oxide probably occurred around the end of January 1845, in a public hall on Washington Street, Boston.
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BREECE, C., E. ISRAEL, and L. FRIEDMAN. "Closing of the nurse-midwifery service at Boston city hospital What were the issues involved?" Journal of Nurse-Midwifery 34, no. 1 (January 1989): 41–48. http://dx.doi.org/10.1016/0091-2182(89)90129-8.

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Rehder, Roberta, Subash Lohani, and Alan R. Cohen. "Unsung hero: Donald Darrow Matson’s legacy in pediatric neurosurgery." Journal of Neurosurgery: Pediatrics 16, no. 5 (November 2015): 483–94. http://dx.doi.org/10.3171/2015.4.peds156.

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Donald Darrow Matson made seminal contributions to the field of pediatric neurosurgery. Born in 1913 in Fort Hamilton, New York, Matson was the youngest of four sons of an army colonel. He graduated from Cornell University and, years later, from Harvard Medical School. Matson selected Peter Bent Brigham Hospital for his neurosurgical training, which was interrupted during World War II. As a neurosurgeon, he worked close to the front lines under Brigadier General Elliot Cutler in Europe, earning a Bronze Star. Matson returned to Boston to become Franc Ingraham’s fellow and partner. He was a masterful surgeon and, with Ingraham, published Neurosurgery of Infancy and Childhood in 1954, the first pediatric neurosurgery textbook in the world. Upon Ingraham’s retirement, Matson became chairman of the department of neurosurgery at Boston Children’s Hospital and Peter Bent Brigham. In 1968, he became the inaugural Franc D. Ingraham Professor of Neurological Surgery at Harvard Medical School. Among his neurosurgical accomplishments, Matson served as President of the Harvey Cushing Society, later known as the American Association of Neurological Surgeons. He was unable to preside at the 1969 meeting that marked the 100th anniversary of Cushing’s birth, having contracted Creutzfeldt-Jakob disease. Matson died at the age of 55, surviving his mentor Ingraham by only 4 years.
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Mechanic, Oren, Celine Pascheles, Gregory Lopez, Alina Winans, Nathan Shapiro, Carrie Tibbles, Richard Wolfe, and Shamai Grossman. "Utilizing the Boston Syncope Observation Management Pathway to Reduce Hospital Admission and Decrease Adverse Outcomes." Western Journal of Emergency Medicine 20, no. 2 (February 28, 2019): 250–55. http://dx.doi.org/10.5811/westjem.2018.11.39657.

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Burke, Redmond P., Evan M. Zahn, and Anthony F. Rossi. "Achieving resonance in a programme for congenital cardiac surgery." Cardiology in the Young 14, S1 (February 2004): 75–82. http://dx.doi.org/10.1017/s1047951104006341.

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In 1995, Miami Children's Hospital recognized an institutional problem with its programme providing surgical treatment for congenital cardiac malformations. There was a high rate of mortality for neonatal surgery, and no patients had survived attempted first stage palliation for hypoplastic left heart syndrome. The hospital enlisted nationally recognized consultants in congenital cardiac surgery and cardiology to review the existing programme, and to make recommendations for improvement. Based on these recommendations, a new team was recruited. The recruits were a young attending surgeon, an interventional cardiologist, and a cardiac intensivist, attracted from recognized centers of excellence in Boston and Toronto.
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Joshi, Kl, and T. Ashraf. "Radiology reporting of vertebral fragility fractures in pilgrim hospital, Boston: preview of a national audit." Clinical Radiology 74 (October 2019): e28. http://dx.doi.org/10.1016/j.crad.2019.09.106.

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42

Berman, Jason. "Model organisms—the critical link between gene discovery and therapeutic intervention." Clinical and Investigative Medicine 41 (November 3, 2018): 21–23. http://dx.doi.org/10.25011/cim.v41i2.31422.

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Jason graduated from the University of Toronto Medical School in 1997 followed by a pediatric residency at the Hospital for Sick Children, a fellowship in pediatric hematology/oncology at Boston Children’s Hospital and post-doctoral training at the Dana-Farber Cancer Institute. He is a professor at Dalhousie University in the Departments of Pediatrics, Microbiology and Immunology and Pathology, was appointed as the director of the Clinician Investigator Program (CIP) and the Graduate Program in Medical Research at Dalhousie (2014), elected president of the Canadian Society for Clinical Investigation (CSCI) (2017) and currently serves as Associate Chair Research in the Department of Pediatrics and Interim VP Research at the IWK, and as an assistant editor of the Journal of Clinical and Investigative Medicine (CIM).
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43

Vilensky, Joel A., Roger C. Duvosin, and Sid Gilman. "The diagnosis of postencephalitic parkinsonism at the neurological unit of Boston City Hospital, 1930–1981." Neurological Sciences 32, no. 2 (February 16, 2011): 343–46. http://dx.doi.org/10.1007/s10072-011-0487-6.

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44

Bhattacharyya, Timothy. "Submitted by Timothy Bhattacharyya, MD, Massachusetts General Hospital, Orthopaedic Associates, 55 Fruit Street, YAW 3C, Boston, MA." Journal of Orthopaedic Trauma 20, no. 7 (August 2006): 512–13. http://dx.doi.org/10.1097/00005131-200608000-00011.

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45

Hu, Howard, Dean Hashimoto, and Mitchell Besser. "Levels of Lead in Blood and Bone of Women Giving Birth in a Boston Hospital." Archives of Environmental Health: An International Journal 51, no. 1 (February 1996): 52–58. http://dx.doi.org/10.1080/00039896.1996.9935994.

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46

Jonas, Richard A., and Gerard R. Martin. "The evolution of cardiac care for children in Washington, DC." Cardiology in the Young 31, no. 8 (August 2021): 1220–27. http://dx.doi.org/10.1017/s1047951121003486.

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AbstractCardiac surgery for CHD was pioneered in Washington, DC by Charles Hufnagel and Edgar Davis working at Georgetown University and Children’s Hospital of the District of Columbia. Children’s Hospital, now Children’s National Hospital, had been established just 5 years after the end of the Civil War. In the 1950s, Davis and Hufnagel undertook many open-heart operations using the technique of surface cooling, hypothermia, and circulatory arrest. Hufnagel and Lewis Scott, who founded the cardiology department at Children’s, were trained in Boston by Gross and Nadas. Judson Randolph, also a trainee of Gross, introduced cardiac surgery using cardiopulmonary bypass and established the General Pediatric Surgery department at Children’s in the 1960s. The transition of hospital staffing from community-based private physicians to full-time hospital employees was often controversial but was complete by the turn of the millennium. The 21st century has seen continuing growth of the new Children’s National Heart Institute and consolidation of several congenital cardiac programmes in Washington, DC.
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47

Vedmurthy, Pooja, Anna L. R. Pinto, Doris D. M. Lin, Anne M. Comi, and Yangming Ou. "Study protocol: retrospectively mining multisite clinical data to presymptomatically predict seizure onset for individual patients with Sturge-Weber." BMJ Open 12, no. 2 (February 2022): e053103. http://dx.doi.org/10.1136/bmjopen-2021-053103.

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IntroductionSecondary analysis of hospital-hosted clinical data can save time and cost compared with prospective clinical trials for neuroimaging biomarker development. We present such a study for Sturge-Weber syndrome (SWS), a rare neurovascular disorder that affects 1 in 20 000–50 000 newborns. Children with SWS are at risk for developing neurocognitive deficit by school age. A critical period for early intervention is before 2 years of age, but early diagnostic and prognostic biomarkers are lacking. We aim to retrospectively mine clinical data for SWS at two national centres to develop presymptomatic biomarkers.Methods and analysisWe will retrospectively collect clinical, MRI and neurocognitive outcome data for patients with SWS who underwent brain MRI before 2 years of age at two national SWS care centres. Expert review of clinical records and MRI quality control will be used to refine the cohort. The merged multisite data will be used to develop algorithms for abnormality detection, lesion-symptom mapping to identify neural substrate and machine learning to predict individual outcomes (presence or absence of seizures) by 2 years of age. Presymptomatic treatment in 0–2 years and before seizure onset may delay or prevent the onset of seizures by 2 years of age, and thereby improve neurocognitive outcomes. The proposed work, if successful, will be one of the largest and most comprehensive multisite databases for the presymptomatic phase of this rare disease.Ethics and disseminationThis study involves human participants and was approved by Boston Children’s Hospital Institutional Review Board: IRB-P00014482 and IRB-P00025916 Johns Hopkins School of Medicine Institutional Review Board: NA_00043846. Participants gave informed consent to participate in the study before taking part. The Institutional Review Boards at Kennedy Krieger Institute and Boston Children’s Hospital approval have been obtained at each site to retrospectively study this data. Results will be disseminated by presentations, publication and sharing of algorithms generated.
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Krevans, Julius R. "Intrinsic Factors: William Bosworth Castle and the Development of Hematology and Clinical Investigation at Boston City Hospital." Bulletin of the History of Medicine 73, no. 2 (1999): 360–61. http://dx.doi.org/10.1353/bhm.1999.0062.

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49

Fouda, Mohammed A., Madeline Karsten, Steven J. Staffa, R. Michael Scott, Karen J. Marcus, and Lissa C. Baird. "Management strategies for recurrent pediatric craniopharyngioma: new recommendations." Journal of Neurosurgery: Pediatrics 27, no. 5 (May 2021): 548–55. http://dx.doi.org/10.3171/2020.9.peds20606.

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OBJECTIVE The goal of this study was to identify the independent risk factors for recurrence or progression of pediatric craniopharyngioma and to establish predictors of the appropriate timing of intervention and best management strategy in the setting of recurrence/progression, with the aim of optimizing tumor control. METHODS This is a retrospective cohort study of all pediatric patients with craniopharyngioma who were diagnosed and treated at Boston Children’s Hospital between 1990 and 2017. This study was approved by the institutional review board at Boston Children’s Hospital. All statistical analyses were performed using Stata software. RESULTS Eighty patients (43 males and 37 females) fulfilled the inclusion criteria. The mean age at the time of diagnosis was 8.6 ± 4.4 years (range 1.2–19.7 years). The mean follow-up was 10.9 ± 6.5 years (range 1.3–24.6 years). Overall, 30/80 (37.5%) patients developed recurrence/progression. The median latency to recurrence/progression was 12.75 months (range 3–108 months). Subtotal resection with no adjuvant radiotherapy (p < 0.001) and fine calcifications (p = 0.008) are independent risk factors for recurrence/progression. An increase (%) in the maximum dimension of the tumor at the time of recurrence/progression was considered a statistically significant predictor of the appropriate timing of intervention. CONCLUSIONS Based on the identified independent risk factors for tumor recurrence/progression and the predictors of appropriate timing of intervention in the setting of recurrence/progression, the authors propose an algorithm for optimal management of recurrent pediatric craniopharyngioma to increase the likelihood of tumor control.
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Gold, Michael R., G. Dec William, Cocca-Spofford Diane, and B. Thompson Taylor. "Esmolol and Ventilatory Function in Cardiac Patients with COPD* *Cardiac and Critical Care Units, Massachusetts General Hospital, Boston." Chest 100, no. 5 (November 1991): 1215–18. http://dx.doi.org/10.1378/chest.100.5.1215.

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