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Journal articles on the topic 'Matched molecular pairs and series'

Author: Grafiati

Published: 2 June 2025

Last updated: 31 July 2025

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1

Ding, Xiaoyu, Chen Cui, Dingyan Wang, et al. "Bioactivity Prediction Based on Matched Molecular Pair and Matched Molecular Series Methods." Current Pharmaceutical Design 26, no. 33 (2020): 4195–205. http://dx.doi.org/10.2174/1381612826666200427111309.

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Background: Enhancing a compound’s biological activity is the central task for lead optimization in small molecules drug discovery. However, it is laborious to perform many iterative rounds of compound synthesis and bioactivity tests. To address the issue, it is highly demanding to develop high quality in silico bioactivity prediction approaches, to prioritize such more active compound derivatives and reduce the trial-and-error process. Methods: Two kinds of bioactivity prediction models based on a large-scale structure-activity relationship (SAR) database were constructed. The first one is ba

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Hu, Ye, Antonio de la Vega de León, Bijun Zhang, and Jürgen Bajorath. "Matched molecular pair-based data sets for computer-aided medicinal chemistry." F1000Research 3 (February 4, 2014): 36. http://dx.doi.org/10.12688/f1000research.3-36.v1.

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Matched molecular pairs (MMPs) are widely used in medicinal chemistry to study changes in compound properties including biological activity, which are associated with well-defined structural modifications. Herein we describe up-to-date versions of three MMP-based data sets that have originated from in-house research projects. These data sets include activity cliffs, structure-activity relationship (SAR) transfer series, and second generation MMPs based upon retrosynthetic rules. The data sets have in common that they have been derived from compounds included in the latest release of the ChEMBL

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Hu, Ye, Antonio de la Vega de León, Bijun Zhang, and Jürgen Bajorath. "Matched molecular pair-based data sets for computer-aided medicinal chemistry." F1000Research 3 (February 21, 2014): 36. http://dx.doi.org/10.12688/f1000research.3-36.v2.

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Matched molecular pairs (MMPs) are widely used in medicinal chemistry to study changes in compound properties including biological activity, which are associated with well-defined structural modifications. Herein we describe up-to-date versions of three MMP-based data sets that have originated from in-house research projects. These data sets include activity cliffs, structure-activity relationship (SAR) transfer series, and second generation MMPs based upon retrosynthetic rules. The data sets have in common that they have been derived from compounds included in the ChEMBL database (release 17)

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Naveja, José J., and Martin Vogt. "Automatic Identification of Analogue Series from Large Compound Data Sets: Methods and Applications." Molecules 26, no. 17 (2021): 5291. http://dx.doi.org/10.3390/molecules26175291.

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Analogue series play a key role in drug discovery. They arise naturally in lead optimization efforts where analogues are explored based on one or a few core structures. However, it is much harder to accurately identify and extract pairs or series of analogue molecules in large compound databases with no predefined core structures. This methodological review outlines the most common and recent methodological developments to automatically identify analogue series in large libraries. Initial approaches focused on using predefined rules to extract scaffold structures, such as the popular Bemis–Mur

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Kumar, Rahul, Maximilian Deng, Kyle Smith, et al. "PATH-54. MULTI-DIMENSIONAL MOLECULAR CHARACTERIZATION OF PATIENT-MATCHED MEDULLOBLASTOMA AT DIAGNOSIS AND RELAPSE." Neuro-Oncology 21, Supplement_6 (2019): vi155. http://dx.doi.org/10.1093/neuonc/noz175.649.

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Abstract INTRODUCTION Recurrent medulloblastoma (MB) confers an abysmal prognosis with ~10% 5-year overall survival. Optimal treatment paradigms for relapsed disease are largely unknown. Conservation of molecular subgroup at relapse has been described and divergent clonal evolution implicated, yet multi-dimensional molecular characterization of larger cohorts are warranted to substantiate these findings and to disclose potential mechanisms underlying treatment failure and disease recurrence. METHODS A multi-institutional series of 85 patient-matched, primary MBs and their relapses was profiled

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Lorentino, Francesca, Fabio Ciceri, Myriam Labopin, et al. "HLA Disparities Impact on Outcomes after Unmanipulated Haploidentical Hematopoietic Stem Cells Transplantation (HaploSCT) in Acute Leukemia: A Study from the Acute Leukemia Working Party of the European Group for Blood and Marrow Transplantation (EBMT)." Blood 126, no. 23 (2015): 399. http://dx.doi.org/10.1182/blood.v126.23.399.399.

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Abstract Background: HaploSCT from unmanipulated graft is a practiced option for high risk acute leukemia (AL) patients (pts) who lack a matched related or unrelated donor (Piemontese, Leukemia 2015). Since several haploidentical donors are available for most pts, selection based on optimal HLA mismatching could be relevant, but evidence on this issue is scarce. We aimed to evaluate the impact of donor-recipient HLA mismatches (HLAmm) on unshared haplotype on HaploSCT outcomes, hypothesizing that the number of HLAmm and the different HLA loci involved could be associated with specific transpla

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Gupta-Ostermann, Disha, Yoichiro Hirose, Takenao Odagami, and Jürgen Bajorath. "Follow-up: Prospective compound design using the ‘SAR Matrix’ method and matrix-derived conditional probabilities of activity." F1000Research 4 (March 23, 2015): 75. https://doi.org/10.12688/f1000research.6271.1.

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Details of the conditional probability calculations on exemplary the matrix provided in Figure 3 of the publication (see Gupta-Ostermann, Hirose, Odagami & Bajorath, Follow-up: Prospective compound design using the ‘SAR Matrix’ method and matrix-derived conditional probabilities of activity, F1000Research 2015, 4:75 , DOI: 10.12688/f1000research.6271.1 ) is provided in an excel sheet.  Informative SARMs from the PRISM library are included. Due to proprietary issues the structural information of compounds is not included. Key and value fragments of SARMs are provided w

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Riera Aroche, Raúl, Esli C. Sánchez Moreno, Yveth M. Ortiz García, et al. "The Transcription Machinery and the Driving Force of the Transcriptional Molecular Condensate: The Role of Phosphates." Current Issues in Molecular Biology 47, no. 7 (2025): 571. https://doi.org/10.3390/cimb47070571.

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The dynamic phosphorylation of the human RNA Pol II CTD establishes a code applicable to all eukaryotic transcription processes. However, the ability of these specific post-translational modifications to convey molecular signals through structural changes remains unclear. We previously explained that each gene can be modeled as a combination of n circuits connected in parallel. RNA Pol II accesses these circuits and, through a series of pulses, matches the resonance frequency of the DNA qubits, enabling it to extract genetic information and quantum teleport it. Negatively charged phosphates re

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Gagné, David, Elmira Shajari, Marie-Pier Thibault, et al. "Proteomics Profiling of Stool Samples from Preterm Neonates with SWATH/DIA Mass Spectrometry for Predicting Necrotizing Enterocolitis." International Journal of Molecular Sciences 23, no. 19 (2022): 11601. http://dx.doi.org/10.3390/ijms231911601.

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Necrotizing enterocolitis (NEC) is a life-threatening condition for premature infants in neonatal intensive care units. Finding indicators that can predict NEC development before symptoms appear would provide more time to apply targeted interventions. In this study, stools from 132 very-low-birth-weight (VLBW) infants were collected daily in the context of a multi-center prospective study aimed at investigating the potential of fecal biomarkers for NEC prediction using proteomics technology. Eight of the VLBW infants received a stage-3 NEC diagnosis. Stools collected from the NEC infants up to

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Makarevic, Anastasia, Carmen Rapp, Steffen Dettling, et al. "Increased Radiation-Associated T-Cell Infiltration in Recurrent IDH-Mutant Glioma." International Journal of Molecular Sciences 21, no. 20 (2020): 7801. http://dx.doi.org/10.3390/ijms21207801.

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Most gliomas are associated with a fatal prognosis and remain incurable because of their infiltrative growth. Consequently, the addition of immunotherapy to conventional therapy may improve patient outcomes. Here, we analyzed T-cell infiltration and, therefore, a major prerequisite for successful immunotherapy in a series of primary (n = 78) and recurrent (n = 66) isocitrate dehydrogenase (IDH)-mutant glioma and their changes following treatment with radio- and/or chemotherapy. After multicolor immunofluorescence staining, T cells were counted in entire tumor sections using a software-based se

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Eapen, Mary, John Klein, Guillermo Sanz, et al. "Donor-Recipient Matching at the HLA-C Locus and Early Outcomes after Unrelated Umbilical Cord Blood Transplant (UCBT)." Blood 112, no. 11 (2008): 153. http://dx.doi.org/10.1182/blood.v112.11.153.153.

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Abstract Previous studies indicate unrelated donor bone marrow transplantation mismatched at HLA-C locus (antigen-level but not allele-level) result in higher acute graft-versus-host disease (GVHD) and mortality. Hematopoietic recovery is not affected by mismatching at this locus. The current selection of cord blood units is based on antigen-level HLA typing at HLA A and B and allele-level at DRB1. The relative importance of matching at HLA-C has not yet been described for unrelated UCBT. To address this question we analyzed hematopoietic recovery, acute GVHD and mortality in 619 UCBT recipien

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Rohan, Thomas E., Mindy Ginsberg, Yihong Wang, et al. "Molecular markers of risk of subsequent invasive breast cancer in women with ductal carcinoma in situ: protocol for a population-based cohort study." BMJ Open 11, no. 10 (2021): e053397. http://dx.doi.org/10.1136/bmjopen-2021-053397.

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IntroductionDuctal carcinoma in situ (DCIS) of the breast is a non-obligate precursor of invasive breast cancer (IBC). Many DCIS patients are either undertreated or overtreated. The overarching goal of the study described here is to facilitate detection of patients with DCIS at risk of IBC development. Here, we propose to use risk factor data and formalin-fixed paraffin-embedded (FFPE) DCIS tissue from a large, ethnically diverse, population-based cohort of 8175 women with a first diagnosis of DCIS and followed for subsequent IBC to: identify/validate miRNA expression changes in DCIS tissue as

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Keats, Jonathan J., Bonnie K. Arendt, Esteban Braggio, et al. "Comparison of Multiple Myeloma Donor Patient Samples and Derived Cell Lines Identifies a Confirmed Hyperdiploid Myeloma Cell Line and Demonstrates Remarkable Genetic Similarity Between Cell Lines and Patient Samples." Blood 112, no. 11 (2008): 2732. http://dx.doi.org/10.1182/blood.v112.11.2732.2732.

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Abstract Our understanding of the molecular pathogenesis of myeloma is largely based on observations made from the available human myeloma cell lines. Cell lines have proved invaluable to the characterization of the known immunoglobulin translocations, recurrent deletions and amplifications, and the development of novel therapies. However, it has long been perceived that the cell lines are not representative of patient samples as they often have complex genomes and not even a single cell line has been described with a typical hyperdiploid karyotype. The absence of a hyperdiploid model system i

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Bateman, Caroline M., Sharon W. Horsley, Tracy Chaplin, et al. "Sequence of Genetic Events in ETV6-RUNX1 Positive B Precursor ALL: Insights from Identical Twins with Concordant Leukaemia." Blood 112, no. 11 (2008): 2. http://dx.doi.org/10.1182/blood.v112.11.2.2.

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Abstract Monozygotic twin pairs with concordant ALL have provided unique insights into the molecular pathogenesis and natural history of childhood leukaemia. Data from twin pair studies and neonatal blood spot screening indicate that ETV6-RUNX1 usually arises as an early or initiating pre-natal event. Its consequence appears to be the generation of a clinically silent or covert but persistent pre-leukaemic clone. Conversion to overt, clinical ALL then requires the acquisition of one or more additional genetic lesions that functionally complement ETV6-RUNX1, often including deletions of the non

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Papaemmanuil, Elli, Inmaculada Rapado, Anthony M. Ford, et al. "The Genomic Landscape of TEL-AML1+ (ETV6-RUNX1) Acute Lymphoblastic Leukaemia." Blood 118, no. 21 (2011): 403. http://dx.doi.org/10.1182/blood.v118.21.403.403.

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Abstract Abstract 403 TEL-AML1 (ETV6-RUNX1) fusions are common (∼25%) in paediatric B cell precursor acute lymphoblastic leukaemia (ALL) and associated with a very favourable prognosis. Our prior studies on monozygotic twins with concordant ALL and ‘backtracking' studies using archived neonatal blood spots established that ETV6-RUNX1 fusion is usually an early or initiating mutational event arising pre-natally. Subsequent studies, have provided strong evidence that additional genetic changes are essential for the clinical development of ALL. Twin studies suggest that these additional events ar

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Ngeljaratan, Luna, Elif Ecem Bas, and Mohamed A. Moustafa. "Unmanned Aerial Vehicle-Based Structural Health Monitoring and Computer Vision-Aided Procedure for Seismic Safety Measures of Linear Infrastructures." Sensors 24, no. 5 (2024): 1450. http://dx.doi.org/10.3390/s24051450.

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Computer vision in the structural health monitoring (SHM) field has become popular, especially for processing unmanned aerial vehicle (UAV) data, but still has limitations both in experimental testing and in practical applications. Prior works have focused on UAV challenges and opportunities for the vibration-based SHM of buildings or bridges, but practical and methodological gaps exist specifically for linear infrastructure systems such as pipelines. Since they are critical for the transportation of products and the transmission of energy, a feasibility study of UAV-based SHM for linear infra

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de la Vega de León, Antonio, and Jürgen Bajorath. "Matched molecular pairs derived by retrosynthetic fragmentation." Med. Chem. Commun. 5, no. 1 (2014): 64–67. http://dx.doi.org/10.1039/c3md00259d.

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Griffen, Ed, Andrew G. Leach, Graeme R. Robb, and Daniel J. Warner. "Matched Molecular Pairs as a Medicinal Chemistry Tool." Journal of Medicinal Chemistry 54, no. 22 (2011): 7739–50. http://dx.doi.org/10.1021/jm200452d.

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19

Ehmki, Emanuel S. R., and Christian Kramer. "Matched Molecular Series: Measuring SAR Similarity." Journal of Chemical Information and Modeling 57, no. 5 (2017): 1187–96. http://dx.doi.org/10.1021/acs.jcim.6b00709.

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Liu, Weifeng, Ying Jiang, and Yuesheng Xu. "A Super Fast Algorithm for Estimating Sample Entropy." Entropy 24, no. 4 (2022): 524. http://dx.doi.org/10.3390/e24040524.

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Sample entropy, an approximation of the Kolmogorov entropy, was proposed to characterize complexity of a time series, which is essentially defined as −log(B/A), where B denotes the number of matched template pairs with length m and A denotes the number of matched template pairs with m+1, for a predetermined positive integer m. It has been widely used to analyze physiological signals. As computing sample entropy is time consuming, the box-assisted, bucket-assisted, x-sort, assisted sliding box, and kd-tree-based algorithms were proposed to accelerate its computation. These algorithms require O(

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Wu, Ying. "Matched soliton pairs of four-wave mixing in molecular magnets." Journal of Applied Physics 103, no. 10 (2008): 104903. http://dx.doi.org/10.1063/1.2913212.

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Warner, Daniel J., Matthew H. Bridgland-Taylor, Clare E. Sefton, and David J. Wood. "Prospective Prediction of Antitarget Activity by Matched Molecular Pairs Analysis." Molecular Informatics 31, no. 5 (2012): 365–68. http://dx.doi.org/10.1002/minf.201200020.

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Lin, YunTe David, Pallavi Akella, Anita Bowman, et al. "Abstract A034: A robust ensemble-feature selection and machine learning approach to identify true somatic variants." Clinical Cancer Research 31, no. 13_Supplement (2025): A034. https://doi.org/10.1158/1557-3265.aimachine-a034.

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Abstract As next-generation sequencing has become an integral part of clinical lab and molecular diagnostics services, identifying true somatic variants from sequencing data is crucial for targeted treatments as well as for cancer research. Traditional, rule-based methods, offering a systemic approach to filter out noise and artifacts, often rely on domain knowledge. Additionally, variant callers such as Mutect or highly sensitive Mutect2 reports SNVs based on their internal probabilistic models can pass noise and sequencing errors as true variants, hence requiring manual inspection. Here we p

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Karp, D. R., C. L. Teletski, D. Jaraquemada, W. L. Maloy, J. E. Coligan, and E. O. Long. "Structural requirements for pairing of alpha and beta chains in HLA-DR and HLA-DP molecules." Journal of Experimental Medicine 171, no. 3 (1990): 615–28. http://dx.doi.org/10.1084/jem.171.3.615.

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To test for the assembly of human MHC class II molecules having an alpha chain from one isotype (HLA-DR, -DQ, or -DP) and the beta chain of another (mixed isotypic pairs), murine fibroblasts were transfected with expressible cDNAs encoding the different class II alpha and beta chains. A rapid and efficient transient transfection system was developed using a polyoma virus-based vector. Typically, 30-50% of cells transfected using this system expressed high levels of class II molecules on their surface, but only with matched isotypic pairs. Biochemical analysis of cells transfected with matched

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Awale, Mahendra, Sereina Riniker, and Christian Kramer. "Matched Molecular Series Analysis for ADME Property Prediction." Journal of Chemical Information and Modeling 60, no. 6 (2020): 2903–14. http://dx.doi.org/10.1021/acs.jcim.0c00269.

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Tian, Ye, Peng Feng, Chenqi Zhu, et al. "Nearly Lattice-Matched GaN Distributed Bragg Reflectors with Enhanced Performance." Materials 15, no. 10 (2022): 3536. http://dx.doi.org/10.3390/ma15103536.

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Heavy silicon-doping in GaN generally causes a rough surface and saturated conductivity, while heavily silicon-doped n++-AlGaN with ≤5% aluminum can maintain an atomically flat surface and exhibit enhanced conductivity. Given this major advantage, we propose using multiple pairs of heavily silicon-doped n++-Al0.01Ga0.99N and undoped GaN instead of widely used multiple pairs of heavily silicon-doped n++-GaN and undoped GaN for the fabrication of a lattice-matched distributed Bragg reflector (DBR) by using an electrochemical (EC) etching technique, where the lattice mismatch between Al0.01Ga0.99

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Deng, Xiaozheng, Shasha Mao, Jinyuan Yang, et al. "Multi-Class Double-Transformation Network for SAR Image Registration." Remote Sensing 15, no. 11 (2023): 2927. http://dx.doi.org/10.3390/rs15112927.

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In SAR image registration, most existing methods consider the image registration as a two-classification problem to construct the pair training samples for training the deep model. However, it is difficult to obtain a mass of given matched-points directly from SAR images as the training samples. Based on this, we propose a multi-class double-transformation network for SAR image registration based on Swin-Transformer. Different from existing methods, the proposed method directly considers each key point as an independent category to construct the multi-classification model for SAR image registr

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Turk, Samo, Benjamin Merget, Friedrich Rippmann, and Simone Fulle. "Coupling Matched Molecular Pairs with Machine Learning for Virtual Compound Optimization." Journal of Chemical Information and Modeling 57, no. 12 (2017): 3079–85. http://dx.doi.org/10.1021/acs.jcim.7b00298.

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Seifert, Michael, Gabriele Schackert, Achim Temme, Evelin Schröck, Andreas Deutsch, and Barbara Klink. "Molecular Characterization of Astrocytoma Progression Towards Secondary Glioblastomas Utilizing Patient-Matched Tumor Pairs." Cancers 12, no. 6 (2020): 1696. http://dx.doi.org/10.3390/cancers12061696.

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Astrocytomas are primary human brain tumors including diffuse or anaplastic astrocytomas that develop towards secondary glioblastomas over time. However, only little is known about molecular alterations that drive this progression. We measured multi-omics profiles of patient-matched astrocytoma pairs of initial and recurrent tumors from 22 patients to identify molecular alterations associated with tumor progression. Gene copy number profiles formed three major subcluters, but more than half of the patient-matched astrocytoma pairs differed in their gene copy number profiles like astrocytomas f

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Kalwak, Krzysztof, Joanna Owoc-Lempach, Ewa Gorczynska, et al. "High Numbers of CD34+ Cells/kg and CD3+ Cells/kg Have No Negative Impact on the Incidence of Severe GvHD and Survival in a Large Series of Children Undergoing Unmanipulated Allogeneic HCT from Matched or Mismatched Unrelated Donors." Blood 108, no. 11 (2006): 5390. http://dx.doi.org/10.1182/blood.v108.11.5390.5390.

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Abstract The aim of the study was to analyze the correlation between the number of transplanted CD34+ cells and CD3+ cells and the incidence of severe Graft versus Host Disease (GvHD) in children undergoing allogeneic hematopoietic cell transplantation from HLA-matched or mismatched unrelated donors. 115 patients (median age 11.4, range 0.7 – 31.6; ALL n=41, AML n=22, CML n=21, MDS/JMML n=10, NHL/HD n=4, SAA/FA n=13, SCID/WAS n=4) underwent unmanipulated allogeneic BMT (n=34) or PBSCT (n=81) from unrelated donors between 1999 and 2005. There were 88 matched- and 27 mismatched donor-recipient p

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Clemenceau, Jean R., Paola Suarez-Meade, Alfredo Quiñones-Hinojosa, and Tae Hyun Hwang. "Abstract 5482: Spatial and multi-omic interrogation of the primary and recurrent glioblastoma microenvironment." Cancer Research 84, no. 6_Supplement (2024): 5482. http://dx.doi.org/10.1158/1538-7445.am2024-5482.

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Abstract Glioblastoma remains as one of the deadliest malignancies with most cases likely to recur. Recent work has focused on characterizing not only glioma cells, but the tumor microenvironment via single-cell and spatial transcriptomic technologies. This has improved our understanding of the high heterogeneity of this disease and described potential tumor domains. However, there is still a need to further understand the changes that occur between the primary and the recurrent lesion. We propose that a spatial, multi-omic characterization of matched primary and recurrent glioblastoma can yie

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Pua, Emmanuel Peng Kiat, Phoebe Thomson, Joseph Yuan-Mou Yang, Jeffrey M. Craig, Gareth Ball, and Marc Seal. "Individual Differences in Intrinsic Brain Networks Predict Symptom Severity in Autism Spectrum Disorders." Cerebral Cortex 31, no. 1 (2020): 681–93. http://dx.doi.org/10.1093/cercor/bhaa252.

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Abstract The neurobiology of heterogeneous neurodevelopmental disorders such as Autism Spectrum Disorders (ASD) is still unknown. We hypothesized that differences in subject-level properties of intrinsic brain networks were important features that could predict individual variation in ASD symptom severity. We matched cases and controls from a large multicohort ASD dataset (ABIDE-II) on age, sex, IQ, and image acquisition site. Subjects were matched at the individual level (rather than at group level) to improve homogeneity within matched case–control pairs (ASD: n = 100, mean age = 11.43 years

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Hutari, Galuh Tunjung. "Model Pembelajaran Kooperatif Tipe Round Tabel Berbantuan Media Tas Pukaki Terhadap Keterampilan Manulis Puisi." Borobudur Educational Review 2, no. 1 (2022): 31–39. http://dx.doi.org/10.31603/bedr.6751.

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Cooperative Learning Model Round Table Assisted by Pukaki Bag Media on Poetry Writing Skills in Fourth Grade Students of SD Negeri Girimulyo. This research uses Quasi Experimental Design with Time Series Design. The research subjects used a total sampling of fourth grade students. The sample used was 20 students. The data collection method was carried out using a performance test of 8. Test the construct validity of the poetry writing skill assessment sheet using expert opinion. The hypothesis was tested using the Wilcoxon matched pairs with the help of SPSS for Windows Cooperative learning mo

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Lukac, Iva, Joanna Zarnecka, Edward J. Griffen, et al. "Turbocharging Matched Molecular Pair Analysis: Optimizing the Identification and Analysis of Pairs." Journal of Chemical Information and Modeling 57, no. 10 (2017): 2424–36. http://dx.doi.org/10.1021/acs.jcim.7b00335.

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Ehmki, Emanuel S. R., and Matthias Rarey. "Exploring Structure-Activity Relationships with Three-Dimensional Matched Molecular Pairs-A Review." ChemMedChem 13, no. 6 (2018): 482–89. http://dx.doi.org/10.1002/cmdc.201700628.

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Majid, Shahn. "Matched pairs of lie groups and Hopf algebra bicrossproducts." Nuclear Physics B - Proceedings Supplements 6 (March 1989): 422–24. http://dx.doi.org/10.1016/0920-5632(89)90488-x.

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Wolff, Sula, and Ann Cull. "‘Schizoid’ personality and antisocial conduct: a retrospective case note study." Psychological Medicine 16, no. 3 (1986): 677–87. http://dx.doi.org/10.1017/s0033291700010424.

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SynopsisA retrospective case note analysis for 30 boys diagnosed as having a ‘schizoid’ personality disorder (Asperger's syndrome) in childhood, and for 30 matched clinic attenders (with systematic follow-up data for 19 matched pairs), showed the incidence of antisocial conduct to be the same in the two groups. However, the ‘schizoid’ boys stole less often and had fewer alcohol problems. In this group antisocial conduct was less related to family disruption and social disadvantage, and more to an unusual fantasy life. Clinical descriptions of a series of ‘schizoid’ boys and girls with conspicu

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Lee, Won-Chul, Daniel Richard Gomez, Jianhua Zhang, et al. "Comprehensive molecular and immune profiling of non-small cell lung cancer and matched distant metastases to suggest distinct molecular mechanisms underlying metastasis." Journal of Clinical Oncology 35, no. 15_suppl (2017): 8541. http://dx.doi.org/10.1200/jco.2017.35.15_suppl.8541.

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8541 Background: Despite complete resection, many non-small cell lung cancer (NSCLC) patients still develop and succumb to distant metastases. Previous studies suggested distant metastasis may be due to genomic evolution and/or suppressed immune surveillance. However, the relationship between specific genomic alterations and immune surveillance has not been systemically studied. Methods: We performed whole exome sequencing, RNA-Seq, methylation microarray, immunohistochemistry using multiple immune markers, and T cell receptor sequencing on 7 pairs of NSCLC primary tumors and matched metastase

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Park, Keon-woo, Yoo-Jeong Shim, and Myeong-jin Lee. "Region-Based Static Video Stitching for Reduction of Parallax Distortion." Sensors 21, no. 12 (2021): 4020. http://dx.doi.org/10.3390/s21124020.

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In this paper, we propose a semantic segmentation-based static video stitching method to reduce parallax and misalignment distortion for sports stadium scenes with dynamic foreground objects. First, video frame pairs for stitching are divided into segments of different classes through semantic segmentation. Region-based stitching is performed on matched segment pairs, assuming that segments of the same semantic class are on the same plane. Second, to prevent degradation of the stitching quality of plain or noisy videos, the homography for each matched segment pair is estimated using the tempor

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Wassermann, Anne Mai, and Jürgen Bajorath. "Large-scale exploration of bioisosteric replacements on the basis of matched molecular pairs." Future Medicinal Chemistry 3, no. 4 (2011): 425–36. http://dx.doi.org/10.4155/fmc.10.293.

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Weber, Julia, Janosch Achenbach, Daniel Moser, and Ewgenij Proschak. "VAMMPIRE: A Matched Molecular Pairs Database for Structure-Based Drug Design and Optimization." Journal of Medicinal Chemistry 56, no. 12 (2013): 5203–7. http://dx.doi.org/10.1021/jm400223y.

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Geppert, Tim, and Bernd Beck. "Fuzzy Matched Pairs: A Means To Determine the Pharmacophore Impact on Molecular Interaction." Journal of Chemical Information and Modeling 54, no. 4 (2014): 1093–102. http://dx.doi.org/10.1021/ci400694q.

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de la Vega de León, Antonio, and Jürgen Bajorath. "Prediction of Compound Potency Changes in Matched Molecular Pairs Using Support Vector Regression." Journal of Chemical Information and Modeling 54, no. 10 (2014): 2654–63. http://dx.doi.org/10.1021/ci5003944.

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Weber, Julia, Janosch Achenbach, Daniel Moser, and Ewgenij Proschak. "VAMMPIRE-LORD: A Web Server for Straightforward Lead Optimization Using Matched Molecular Pairs." Journal of Chemical Information and Modeling 55, no. 2 (2015): 207–13. http://dx.doi.org/10.1021/ci5005256.

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Hussain, Jameed, and Ceara Rea. "Computationally Efficient Algorithm to Identify Matched Molecular Pairs (MMPs) in Large Data Sets." Journal of Chemical Information and Modeling 50, no. 3 (2010): 339–48. http://dx.doi.org/10.1021/ci900450m.

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Kalinowsky, Lena, Julia Weber, Shantheya Balasupramaniam, Knut Baumann, and Ewgenij Proschak. "A Diverse Benchmark Based on 3D Matched Molecular Pairs for Validating Scoring Functions." ACS Omega 3, no. 5 (2018): 5704–14. http://dx.doi.org/10.1021/acsomega.7b01194.

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Hu, Ye, and Jürgen Bajorath. "Hierarchical Analysis of Bioactive Matched Molecular Pairs, Encoded Chemical Transformations, and Associated Substructures." Molecular Informatics 35, no. 10 (2016): 483–88. http://dx.doi.org/10.1002/minf.201600092.

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Sampson, Juliana, Nihar Sheth, Vishal N. Koparde, et al. "Whole Exome Sequencing To Estimate Alloreactivity Potential Between Donors and Recipients In Stem Cell Transplantation." Blood 122, no. 21 (2013): 150. http://dx.doi.org/10.1182/blood.v122.21.150.150.

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Abstract Graft versus host disease (GVHD) continues to afflict allogeneic hematopoietic stem cell transplant (SCT) recipients despite HLA matching at the molecular level. This is largely a consequence of minor histocompatibility antigen (mHA) variation between the donors and recipients resulting in alloreactivity. To determine the extent of potential antigenic variation at a molecular level, whole exome sequencing (WES) was performed on DNA samples from nine HLA-matched donor-recipient (D-R) pairs to catalogue the sequence variation. TruSeq exome enriched libraries were prepared using Illumina

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Monavari, Sergej. "Double nested Hilbert schemes and the local stable pairs theory of curves." Compositio Mathematica 158, no. 9 (2022): 1799–849. http://dx.doi.org/10.1112/s0010437x22007606.

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We propose a variation of the classical Hilbert scheme of points, the double nested Hilbert scheme of points, which parametrizes flags of zero-dimensional subschemes whose nesting is dictated by a Young diagram. Over a smooth quasi-projective curve, we compute the generating series of topological Euler characteristic of these spaces, by exploiting the combinatorics of reversed plane partitions. Moreover, we realize this moduli space as the zero locus of a section of a vector bundle over a smooth ambient space, which therefore admits a virtual fundamental class. We apply this construction to th

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Cala, S. J., J. Edyvean, M. Rynn, and L. A. Engel. "O2 cost of breathing: ventilatory vs. pressure loads." Journal of Applied Physiology 73, no. 5 (1992): 1720–27. http://dx.doi.org/10.1152/jappl.1992.73.5.1720.

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We compared the O2 cost of breathing (VO2resp) at high levels of ventilation (HV) with that against high inspiratory pressure loads (HP) using an external elastance when end-expiratory volume, work rate (W), and pressure-time product (P) were matched at two levels of ventilation and elastic loading. Each of five normal subjects performed three pairs of loaded runs (one HV and one HP) bracketed by two resting runs. Mean O2 consumption from the pairs of resting runs was subtracted from that of each of the loaded runs to give VO2resp during loaded breathing. Matching for W and P was within 15% in

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