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Dissertations / Theses on the topic 'Materia medica in art'

Author: Grafiati
Published: 4 June 2021
Last updated: 28 July 2025

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1

Chu, Jessica Hoi-Yan. "Investigating in vitro anticancer properties of Malaysian rainforest plants : Acalypha wilkesiana Müll, Arg. Archidendron ellipticum (Blume) Hassk., Duabanga grandiflora Walp., Pseuduvaria macrophylla (Oliv.) Merr." Thesis, University of Nottingham, 2014. http://eprints.nottingham.ac.uk/28017/.

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Malaysia is ranked the 12th richest country for its biological diversity of plant species by the Convention on Biological Diversity and this project aims to contribute to existing knowledge of Malaysian rainforest plants, Acalypha wilkesiana, Duabanga grandiflora, Archidendron ellipticum and Pseuduvaria macrophylla, for the treatment of cancer. A. wilkesiana (Euphorbiaceae) whole plant EtOH and EtOAc extracts inhibited growth of breast cancer MDA-MB-468 cells (GI50: 22.7 and 15.9 μg/ml) and revealed preference over non-transformed MRC5 fibroblasts (GI50: 46.6 and 53.3 μg/ml, respectively). EtO
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Boivie, Joakim. "Digital Wanderlust : Med digital materia som följeslagare i skapandet." Thesis, Blekinge Tekniska Högskola, Institutionen för teknik och estetik, 2017. http://urn.kb.se/resolve?urn=urn:nbn:se:bth-14703.

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Med detta kandidatarbete vill jag synliggöra datorns roll i digitalt skapande. Detta genom att se till den kod som utgör digitala objekt som ett materia, och utifrån Karen Barads teorier om agentiell realism samt forskning i digital materialitet bjuda in denna digitala materia som en aktör i skapandeprocessen. Jag har strävat efter en inblick i hur digital materia framträder när den tillåts verka som en aktör, hur den tar ett uttryck och yttrar sig. Jag har engagerat mig i digital materia med diffraktion och remix som metod, vilket tillåtit mig en djupare inblick i det samt en inkluderande pro
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Mokwala, Phatlane William. "Antibacterial activity of plants that are used in the treatment of heartwater in livestock and the isolation and identification of bioactive compounds from Petalidium oblongifolium and Ipomoea adenoides." Pretoria : [s.n.], 2006. http://upetd.up.ac.za/thesis/available/etd-06082007-160159.

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Golden, Isaac, and homstudy@netconnect com au. "The potential value of homoeoprophylaxis in the long-term prevention of infectious diseases, and the maintenance of general health in recipients." Swinburne University of Technology, 2002. http://adt.lib.swin.edu.au./public/adt-VSWT20050228.150047.

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Homoeoprophylaxis (HP) is the use of homoeopathically prepared substances to prevent targeted infectious diseases in recipients. Its first use in an epidemic of Scarlet Fever was documented in 1801. It has been used throughout the world since then for both short-term and long-term preventative purposes. The effectiveness and safety of Golden�s long-term HP program using homoeopathically prepared substances to prevent targeted infectious diseases in recipients was tested through two research projects. The effectiveness of the program could not be established with statistical certainty given the
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Greening, Daniel John. "Art, landscape and material : subject into media." Thesis, University of Wolverhampton, 2010. http://hdl.handle.net/2436/299209.

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A research investigation that illustrates the development of the European landscape tradition as an unbroken interactive and material movement, through discussion of artists from Annibale Carracci (1560-1609) to Richard Long (1945 –). The contribution of each artist within their respective epoch will be used to propose that the subject of landscape has become an actual creative medium, integral to and consistent with the external Plein-Air technique. Thus, presenting a ‘creative narrative’ from the observed into the articulated that will demonstrate how the examination and representation of ac
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Tränkle, Marion. "Material agency and performative dynamics in the practices of media art." Thesis, Brunel University, 2011. http://bura.brunel.ac.uk/handle/2438/8767.

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This dissertation identifies a strategy of artistic inquiry within contemporary media art practice. It applies the concept of material that acts in an agential capacity, generating performative acts. It argues that the emergent potentials of materials and their interconnectedness with the compositional layers of a work can facilitate modes of effecting change in the artistic system. Through the theoretical investigation of the production processes of physical structures and environments, the thesis focuses on the compositional dynamics within which materials actively perform. It examines how L
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Ivaškevičienė, Miglė. "Kaišiadorių apylinkėse tautinėje vaistininkystėje vartojamų (vartotų) augalų etnofarmacinis tyrimas." Master's thesis, Lithuanian Academic Libraries Network (LABT), 2014. http://vddb.library.lt/obj/LT-eLABa-0001:E.02~2014~D_20140618_215130-34444.

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Tyrimo tikslas surinkti ir susisteminti tautinės vaistininkystės žinias Kaišiadorių apylinkėse. Rezultatai: Apklausų - interviu metu apklausti 23 respondentai. Užfiksuotos 155 natūralios vaistingosios medžiagos. Didžiausią jų dalį sudarė augalai, kurių įvairovė siekia 62 augalų šeimas, taip pat užfiksuoti 3 gyvūnai, vartojami kaip gydomoji priemonė. Išvados: 1. Anketavimo – asmeninio interviu metu gauta medžiaga susisteminta pagal vaistingųjų medžiagų kilmę. Vyrauja augalinės kilmės vaistingosios medžiagos 77,02%, gyvūninės kilmės vaistingosios medžiagos sudarė 9,94%, kitos – nei vienai ir min
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李佩霞. "海外中藥/植物藥/傳統草藥質量標準和法規研究". HKBU Institutional Repository, 2014. https://repository.hkbu.edu.hk/etd_oa/8.

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國際市場對植物藥和中藥的需求不斷增加而且市場潛力巨大，植物藥為主的中藥進入國際市場，必須符合國際植物藥的質量要求及規管。可是一直以來成功在海外註冊的中藥產品寥寥無幾，這都源於海外法規對中藥及植物藥的要求比較嚴謹，尤其重視中草藥安全性、質量性和有效性的標準。本文研究分為兩部分：(一)介紹海內外主要藥典包括中國(CP)、日本(JP)、歐洲(EP)、英國(BP)及美國藥典(USP-NF)，其應用地區廣泛、影響力大，建立的檢測方法水準較高。主要研究各藥典對植物藥及傳統草藥質量標準的概況，及對各國藥典收載的5種基原植物相同生藥與中國藥典的質量檢測標準作比較，為完善中藥質量標準提供借鑒；(二)研究闡述了海外相關政府機構包括歐盟對註冊植物藥或中藥的規管和註冊要點，通過分析歐盟針對草藥藥品的簡化註冊程序 (Simplified registration procedure, SR)，探討其註冊的難度及關鍵問題，以成功註冊之例子，為中藥進入國際市場提供參考，對中藥國際化之路有所啟示。中藥要解決的註冊的限制，需要從提升中藥自身質量標準及國際合作等方面，才能使中藥增強國際競爭力，順利跨越國際技術性註冊的限制。中藥走向國際的過程，是中醫藥與現代西醫藥相互融合的必經階段，最終達到標準統一的過程，二者的不斷融會和貫通，將成為新世紀醫藥產業的一大熱點。 關鍵詞： 中藥規管；植物藥規管；藥典；質量檢測標準；歐盟註
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Cronier, Marie. "Recherches sur l'histoire du texte du De materia medica de Dioscoride." Paris, EPHE, 2007. http://www.theses.fr/2007EPHE499D.

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Cette étude se propose de reconstituer la manière dont le De materia medica de Dioscoride, le plus important traité de pharmacie de la fin de l'Antiquité et de tout le Moyen Age méditerranéen, fut transmis, recopié, lu et étudié depuis sa rédaction (en grec), dans la seconde moitié du Ier siècle de notre ère, jusqu'aux premières éditions imprimées, à la Renaissance. Pour cela, l'ensemble de la tradition manuscrite directe est examinée: à chacun des représentants (papyrus et manuscrits) est consacrée une étude particulière détaillée, portant sur ses aspects codicologiques, historiques et philol
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10

Wang, Di, and 王迪. "Molecular and biochemical characterization of therapeutic properties of paeoniae-glycyrrhiza decoction, a Chinese herbal preparation, against antipsychotic-associated hyperprolactinemia." Thesis, The University of Hong Kong (Pokfulam, Hong Kong), 2013. http://hdl.handle.net/10722/193412.

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Hyperprolactinemia (hyperPRL) is a highly prevalent adverse side effect in antipsychotic therapy as most antipsychotic drugs are dopamine D2 receptor antagonists. Peony-Glycyrrhiza Decoction (PGD, 芍藥甘草湯) is a classic Chinese herbal formula initially used to treat muscle pain and spasm. Our pilot clinical studies have confirmed the effectiveness of PGD in alleviating antipsychotic-induced hyperPRL in patients with schizophrenia. In the present study, we further examined the effects of PGD, its individual herbal preparations and major compounds in suppressing prolactin (PRL) hyperactivity in in
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11

周芝苡. "中藥續斷質量標準的比較分析". HKBU Institutional Repository, 2014. https://repository.hkbu.edu.hk/etd_oa/7.

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續斷傳統上具補肝腎強筋骨功效，為中醫骨傷科、婦科之常用要藥，臨床上除可用於腰膝酸軟、跌打損傷、骨折等症，亦用於治療胎漏、胎動不安、滑胎，常用於孕婦安胎之用。現代藥理研究亦表明續斷具有抗骨質疏作用、促進骨損傷癒合、降低在體和離體子宮的收縮幅度及緊張度、具免疫調節活性、具抗氧化抗衰老活性、保護神經元細胞作用、抗阿茲海默症作用、抗菌抗炎、抗腫瘤活性、對機體不同器官病變的保護作用、改善糖尿病等作用。 觀乎目前大部分中藥材的藥理研究，對於實驗所使用之中藥材往往只由個別學者進行經驗鑒別，並沒有對其進行嚴謹的鑒別。過往曾有學者提出藥食兩用的枸杞子含有毒性的阿托品類生物鹼的結論，令中藥界震驚並憂慮枸杞子的安全性；後來不少學者提出該學者的研究所指的“枸杞子”並不一定與中藥所使用的枸杞子品種一樣。由此可見，品種鑒別對中藥的藥理研究甚為重要，差若毫釐，缪以千里，使用不正確的原料作研究對像，有可能出現矛盾的結果，亦錯誤評價中藥的療效性、安全性等方面，窒礙中藥日後的研究發展。 續斷，在過往《中國藥典》中曾多次修訂藥材來源以及藥材原植物拉丁名，至使過往一些對續斷的藥理研究或综述可能並未包含真正的續斷，或取用了非續斷原藥材的植物進行研究及分析。目前香港並沒有法定的中藥材標準，大部份研究均是參考《中國藥典》，而2005年香港衛生署出版的《香港中藥材標準》則屬於指導性質，並無實際法律效力，只屬參考性質，導致研究人員
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劉知名. "香港市場藥食兩用中藥材的調查整理與鑒別研究". HKBU Institutional Repository, 2015. https://repository.hkbu.edu.hk/etd_oa/126.

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目的：國內中藥材品種混亂的現象普遍，而香港的中藥材大多是由國內進口，其中相當部分將轉口至世界各地，中藥材品種混亂的問題對本港乃至各地都有影響。本課題旨在對香港藥食兩用中藥材進行調研整理和鑒別研究。通過市場調查獲得香港市場流通過程中的藥食兩用的中藥材、中藥飲片品種的商品規格、價格、產地資訊。獲取藥食兩用中藥材和中藥飲片的代用品、偽劣品種和品種混淆的情況。通過品種考證鑒定香港市面流通中藥材混淆品種的基源。發現存在的問題並提出解決意見。 方法：通過實地走訪調查、詢問、填寫調查表等方式，對香港十八個行政區的中藥批發商、中藥零售企業、食品零食商進行調查，並拍攝被調查的藥材和飲片、替代品、混淆品的照片作為影像記錄。 結果：1）香港藥食兩用藥材價格差異大，質量參差不齊 2）中藥規格等級劃分混亂，價格透明度低。3）香港部份市售的中藥材小薊、枳椇子、金銀花、青果、昆布、薏苡仁、酸棗仁、鮮白茅根、枸杞子、山藥基原與藥典存在差異。4 ）根據大棗的歷史沿革，推斷案（大棗、黑棗）為鼠李科植物棗Ziziphus jujuba Mi11.的成熟果實。 討論：1）香港藥食兩用中藥材存在基原混亂、規格劃分不統一、質量不穩定等問題。2）為保證中藥材質量，建議《香港中藥材標準》強制實施。3）開展基礎研究，開發新資源，尋找中藥代用品。4）完善中醫藥相關法律法規，嚴格監控中藥生產、購進、銷售各環節。5）發展高質量、高附加值
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陈全兰. "中药萆薢类葯材的鉴定研究". HKBU Institutional Repository, 2013. http://repository.hkbu.edu.hk/etd_ra/1363.

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Poletto, Roberto. "Uma trajetória por escrito: Pedro Montenegro SJ. e sua materia medica misionera." Universidade do Vale do Rio dos Sinos, 2014. http://www.repositorio.jesuita.org.br/handle/UNISINOS/3335.

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Submitted by Maicon Juliano Schmidt (maicons) on 2015-04-22T14:50:53Z No. of bitstreams: 1 Roberto Poletto.pdf: 3420775 bytes, checksum: d922c338ab5f9ef3a1b9fb2d16af6565 (MD5)<br>Made available in DSpace on 2015-04-22T14:50:53Z (GMT). No. of bitstreams: 1 Roberto Poletto.pdf: 3420775 bytes, checksum: d922c338ab5f9ef3a1b9fb2d16af6565 (MD5) Previous issue date: 2014-01-31<br>CAPES - Coordenação de Aperfeiçoamento de Pessoal de Nível Superior<br>CNPQ – Conselho Nacional de Desenvolvimento Científico e Tecnológico<br>Esta dissertação tem como foco a trajetória de Pedro Montenegro. Nascido na
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Leon, Christine. "The botany and macroscopy of Chinese materia medica : sources, substitutes and sustainability." Thesis, University of Westminster, 2017. https://westminsterresearch.westminster.ac.uk/item/q12q7/the-botany-and-macroscopy-of-chinese-materia-medica-sources-substitutes-and-sustainability.

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Interest in Traditional Chinese Medicine (TCM) is global. The burgeoning international trade in its crude and processed plant ingredients (Chinese materia medica - CMM) reflects demand across all sectors of healthcare, yet the identification of source plants and CMM has been overlooked for many years leading to problems in safety, quality, efficacy and sustainable sourcing. The Guide (Chinese medicinal plants, herbal drugs and substitutes: an identification guide, Leon & Lin, Kew Publishing, 2017), which forms the core of this dissertation by publication, presents a fresh approach to the ident
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Prinsloo, Gerhard. "Isolation of an anti-HIV compound from Elaeodendron croceum (Thunb.) DC." Pretoria : [s.n.], 2006. http://upetd.up.ac.za/thesis/available/etd-06082007-164348.

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Zhang, Jieneng. "Jin shi liu nian (1989-2005) Xianggang Zhong yao bu liang fan ying shi gu de fen xi yan jiu /." click here to view the abstract and table of contents, 2006. http://net3.hkbu.edu.hk/~libres/cgi-bin/thesisab.pl?pdf=b1998697xa.pdf.

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Bin, Break Mohammed Khaled Ali. "Semi-synthesis of novel cardamonin analogues and identification of a highly active Cu(II)-cardamonin complex that inhibits migration and induces apoptosis via inhibition of mTOR expression." Thesis, University of Nottingham, 2018. http://eprints.nottingham.ac.uk/52537/.

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Lung cancer is considered a major health concern and is responsible for most cancer-related deaths. Nasopharyngeal carcinoma (NPC) is another type of cancer that is predominantly in China and has a low survival rate, which makes it a serious health issue. There is currently no cure for lung cancer and NPC, so it was decided to investigate derivatives of the highly bioactive natural product, cardamonin, for a potential drug candidate. 19 analogues of cardamonin were synthesised and tested against A549 (lung) and HK1 (NPC) cell lines. The techniques employed in synthesising the analogues were on
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Sim, Jack. "In-vitro characterisation of targeting ligands for enhanced delivery across the blood-brain barrier." Thesis, Cardiff University, 2018. http://orca.cf.ac.uk/112529/.

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The blood-brain barrier (BBB) is the most extensive and restrictive barrier to brain delivery for therapeutic agents. A low proportion of low molecular-weight agents can cross into the CNS. This decreases further as the molecular weight increases, meaning therapeutic antibodies, oligonucleotides and other supramolecular entities effectively cannot reach therapeutic levels within the CNS. Targeting ligands against receptors thought to undergo transcytosis across the brain microvascular endothelial cells (BMECs), can boost CNS delivery of therapeutics. Understanding these mechanisms, in an in-vi
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Alali, Muqdam. "Amino acid-modified ultrafine superparamagnetic iron oxide nanoparticles : fabrication, size characterisation and potential cytotoxicity and cell interaction." Thesis, University of Nottingham, 2018. http://eprints.nottingham.ac.uk/52434/.

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The potential applications of transition metals-based nanoparticles are expanding in the biomedical field. Oxides of iron are the matter of investigation in this study where various preparations of ultrafine superparamagnetic iron oxide nanoparticles (USPIONs) were fabricated using flow injection technology with spinning disc reactor. Basically, two types of preparation parameters were examined; first, instrument-related (physical) parameters and, second, chemistry-related parameters. USPIONs fabricated by this instrument showed fine-tuning size adjustment. Subsequent surface modification of t
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Tchoryk, Aleksandra. "3D spheroid models for in vitro evaluation of nanoparticles for cancer therapy." Thesis, University of Nottingham, 2018. http://eprints.nottingham.ac.uk/51750/.

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Many different nanoparticle delivery systems have been reported as potential cancer therapeutics, however, the tumour penetration and uptake characteristics have been determined for very few systems. Animal models are effective for assessing tumour localisation of nanosystems, but difficult to use for studying penetration beyond the vasculature. In this work, defined HCT 116 colorectal cancer spheroids were used to study the effect of nanoparticle size and surface modifications on their penetration and uptake. Incubation of spheroids with Hoechst 33342 resulted in a dye gradient which facilita
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Al-Hachami, Wathiq. "Investigation of pico-litre inkjet printing for nano-gram scale solid form screening of pharmaceuticals." Thesis, University of Nottingham, 2018. http://eprints.nottingham.ac.uk/52031/.

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The tendency of the majority of active pharmaceutical ingredients (APIs) to exist in different solid forms with keeping their chemical structures is called polymorphism. This phenomenon has gained a lot of interest in the pharmaceutical industry, hoping to avoid producing unexpected transformations of compounds during and after synthesis. The optimal way to avoid that is to subject the API, at the early stage of development, under various conditions in order to obtain an elegant (safe, effective, and stable) drug for the next formulation step. The aim of this thesis was to investigate some fac
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Fridgeirsdottir, Gudrun A. "The development of a multiple linear regression model for aiding formulation development of solid dispersions." Thesis, University of Nottingham, 2018. http://eprints.nottingham.ac.uk/52176/.

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As poor solubility continues to be problem for new chemical entities (NCEs) in medicines development the use and interest in solid dispersions as a formulation-based solution has grown. Solid dispersions, where a drug is typically dispersed in a molecular state within an amorphous water-soluble polymer, present a good strategy to significantly enhance the effective drug solubility and hence bioavailability of drugs. The main drawback of this formulation strategy is the inherent instability of the amorphous form. With the right choice of polymer and manufacturing method, sufficient stability ca
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Al-Hayali, Mohammed Zuhair Khaleel. "Characterisation of anticancer properties of a novel and naturally isolated bisindole alkaloid, conofolidine." Thesis, University of Nottingham, 2018. http://eprints.nottingham.ac.uk/52200/.

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Natural products play a pivotal role in the exploration of new cancer therapies of which the plant kingdom is a substantial source. Conofolidine is a novel bisindole alkaloid isolated from Malayan plant Tabernaemontana Corymbosa and belongs to the family of the known vinca alkaloid conophylline. To our knowledge, no published work existed at the time of commencement of this project. Herein, we report for the first time recognition of conofolidine’s exceptional anticancer activity, from a panel of Malayan bisindoles (namely leucophyllidine, bipleiophylline and alstonia macroline-sarpagine bisin
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Alnahar, Saja. "Factors affecting utilisation of biosimilar medicines in England." Thesis, University of Nottingham, 2018. http://eprints.nottingham.ac.uk/52422/.

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Biological medicinal products (BMPs) are medicinal products extracted from, or synthesised by, a biological system. While BMPs have been proven to be effective in treating chronic and life-threatening diseases, the utilisation of these medicines was associated with creating financial burdens for healthcare systems worldwide. Expiry of patents and marketing exclusivity rights offers an opportunity to develop similar and not identical follow-on copies called ‘biosimilar medicinal products’ (BSPs). The inability to produce an identical copy of the original product is related to the heterogenic mo
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Al, Kurdi Zakieh. "Subcutaneous and oral delivery of insulin." Thesis, University of Greenwich, 2015. http://gala.gre.ac.uk/18146/.

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The aim of this project was to prepare, optimize, characterize and compare a subcutaneous/oral delivery system for insulin. The effect of various low molecular weight chitosans (LMWCs) on the stability of insulin, using USP HPLC methods, was investigated. Insulin was found to be stable in a polyelectrolyte complex (PEC) consisting of insulin and LMWC in the presence of Tris-buffer at pH 6.5. In the presence of LMWC, the stability of insulin increased with decreasing molecular weight of LMWC; 13 kDa LMWC was the most efficient molecular weight for enhancing the physical and chemical stability o
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Pousinis, Petros. "Evaluation of rodent models of osteoarthritis using lipidomic profiling and behavioural studies." Thesis, University of Nottingham, 2017. http://eprints.nottingham.ac.uk/45382/.

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Osteoarthritis (OA) is a complex, multifactorial, and slowly progressive disease where there is currently no effective medical treatment. Research in understanding the mechanisms of OA has been advanced by preclinical studies in rodent models of OA. Recent evidence highlights the role of different classes of lipids in OA pathogenesis. Therefore, the main aim of this thesis was to apply both targeted and untargeted (global) lipidomics mass spectrometry based an alytical methods, in conjunction with univariate and multivariate statistical analysis, in various tissues from three established roden
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Gulfam, Muhammad. "Development of functional micelles from biodegradable amphiphilic block copolymers for drug delivery and tumour therapy." Thesis, University of Nottingham, 2017. http://eprints.nottingham.ac.uk/47106/.

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Drug delivery systems in the size range of ~ 10-250 nm are enabling tools for site-specific targeting and controlled release applications. To take advantage of these capabilities, various nanocarriers e.g., micelles, dendrimers, liposomes, nanoparticles, nanocapsules, nanotubes, and nanogels, have been designed for drug delivery. Specifically, micelle-based drug carrier systems have emerged as promising tools for site-specific delivery and controlled release applications. Despite several advantages over conventional drugs, some limitations of micelle-based drug delivery have also been reported
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Xiao, Ting Ting. "The impact of angelicae sinensis radix and its herb-pairs in embryonic development." HKBU Institutional Repository, 2015. https://repository.hkbu.edu.hk/etd_oa/185.

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Background and purpose: Angelicae Sinensis Raidx (Chinese Angelica, Dang Gui, DG), the dry root of Angelica sinensis (Oliv.) Diels, is one of the most popular herbs used around the world. It has been named as the “female ginseng and served as an indispensable herb to treat many obstetrical and gynecological diseases. Traditionally, DG was recommended to pregnant women to ease delivery and to eliminate complications. It is believed that the body of DG (Dang Gui Shen, DGS) is superior in nourishing blood, while the tail of DG (Dang Gui Wei, DGW) is commonly used to remove blood stagnation. Clin
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Beech, Karen E. "Processing and formulation insights for designing quality into lyophilised biopharmaceuticals." Thesis, University of Nottingham, 2015. http://eprints.nottingham.ac.uk/33176/.

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This thesis makes an original contribution to the field of formulation development by providing new experimental data and insights into the effect of processing and formulation conditions on the quality of lyophilised biopharmaceuticals. The quality attributes of lyophilised products include: a quick reconstitution time, product elegance and protein stability, which are known to be affected by processing and formulation parameters. However, choice of formulation excipients or processing conditions often relies on previous experience rather than mechanistic insight. The motivation of this thesi
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Chanakit, Teeraporn. "Thai stakeholder's perceptions of the introduction of the Doctor of Pharmacy programme." Thesis, University of Nottingham, 2016. http://eprints.nottingham.ac.uk/37208/.

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Global pharmacy education and pharmacy practice continue to face remarkable changes. Many countries are undergoing major transformations in the field of pharmacy education. In developing countries, there is an increasing trend towards adopting the PharmD degree. Thai pharmacy education has transitioned from having two entry-level degrees – a 5-year BPharm (with three main tracks: pharmaceutical care, pharmaceutical sciences, social and administrative pharmacy) and a traditional 6-year PharmD (pharmaceutical care) programme – to a single national 6-year PharmD programme or ‘an all-PharmD progra
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朱家駿. "廣藥和南藥的來源、分佈與應用歷史考". HKBU Institutional Repository, 2010. http://repository.hkbu.edu.hk/etd_ra/1139.

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33

Dodington, Sean Rhys. "Nutritional abnormalities in patients receiving long-term home parenteral nutrition." Thesis, Cardiff University, 2018. http://orca.cf.ac.uk/111542/.

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The last two decades have seen an increased drive to administer parenteral nutrition (PN) to patients in their home environments, thereby reducing associated hospital costs and improving patient quality of life. The occurrence of deranged nutritional biochemistry results has baffled PN experts for years because PN additives are marketed for the general needs of patients and PN is tailored to each patient’s requirements (both formulation and regimen). This thesis documents the investigations into HPN population characteristics, the extent of nutritional abnormalities (deficiencies and excesses)
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Sklepari, Meropi. "Stability and biophysical characterisation of protein therapeutics." Thesis, University of Warwick, 2017. http://wrap.warwick.ac.uk/98558/.

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For the past two decades, the development of protein therapeutics has significantly expanded with numerous biopharmaceutical and biosimilar products entering the medicine market every year, and even more queuing in the pipeline globally. Biologics are very complex molecules and therefore extremely sensitive to minor changes in the manufacturing process, which can result in heterogeneity and affect the stability, potency and immunogenicity of the final product. Public health organisations, such as EMA (European Medicines Agency), require that biological products should be extensively tested for
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Shipton, F. N. "The in vitro pharmacological activities of Pericampylus glaucus (Lam.) Merr. and their relation to ethnomedicinal use." Thesis, University of Nottingham, 2017. http://eprints.nottingham.ac.uk/44484/.

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Malaysia’s rainforests have a great biodiversity, a lot of which has yet to be studied. This presents researchers with the opportunity for the discovery of new chemical structures which may be new leads in drug discovery. With problems such as antibiotic resistance and the need for improved drugs for the treatment of diseases such as cancer and neurodegenerative diseases, there is need for more research into drug discovery. The focus of the research covered in this document is on Pericampylus glaucus, a common climbing plant for which there is limited literature available. The aim of this stud
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Štaka, Ivana. "Novel gel-associated drug loaded nanocarriers for intratumoural delivery." Thesis, University of Nottingham, 2018. http://eprints.nottingham.ac.uk/48782/.

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Cancer is one of the leading causes of death worldwide with approximately 14 million new cases reported in 2012. Systemic chemotherapy is widely used to treat cancer and can often result in toxicity and adverse side effects. To reduce these adverse side effects and potentially increase efficacy, the focus of this thesis is to create a new intratumoural drug delivery platform for patients who are too ill to receive systemic chemotherapy or with inoperable tumours. Herein, an injectable formulation composed of a hydrogel and drug-loaded polymeric nanocapsules (NCs) was developed, to deliver the
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Lockey, Christine. "Structural and ligand binding investigation of VanS, a protein involved in antibiotic resistance." Thesis, University of Warwick, 2017. http://wrap.warwick.ac.uk/102648/.

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VanS is an integral membrane protein, and a receptor histidine kinase representing on half of the VanSR two component system. In the presence of vancomycin, as well as certain other antibiotics, VanS undergoes autophosphorylation at a conserved histidine residue and then transfers this phosphoryl group to a conserved aspartate on VanR. The phosphorylated form of VanR binds to the promoter region of the vanHAX operon, inducing expression of these genes, which confer glycopeptide antibiotic resistance to the cell. Although the vancomycin resistance mechanism is mostly well-characterised, questio
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Fung, Hau Yee. "Development of the Hong Kong Chinese materia medica Standards monograph of Lini semen." HKBU Institutional Repository, 2018. https://repository.hkbu.edu.hk/etd_oa/531.

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The development of the monograph of a commonly used Chinese medicine, Lini Semen, for the Hong Kong Chinese Materia Medica Standards (HKCMMS) was recorded. HKCMMS is a set of reliable and internationally recognized standards of Chinese medicine. The monograph of Lini Semen was proposed, endorsed, and under editorial phase for the publication of the 9th volume of HKCMMS. In the proposed HKCMMS monograph of Lini Semen, besides regular content such as macroscopic and microscopic identification, and TLC identification, a HPLC fingerprint method and two assay methods were developed. All methods wer
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Kammerer, David E. "A model for media-centered [i.e. medium-centered] art instruction a discipline-based, thematic approach /." Instructions for remote access. Click here to access this electronic resource. Access available to Kutztown University faculty, staff, and students only.`, 1991. http://www.kutztown.edu/library/services/remote_access.asp.

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40

Bian, He. "Assembling the Cure: Materia Medica and the Culture of Healing in Late Imperial China." Thesis, Harvard University, 2014. http://dissertations.umi.com/gsas.harvard:11449.

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This dissertation examines the intersection between the culture of knowledge and socio-economic conditions of late Ming and Qing China (1550-1800) through the lens of materia medica. I argue that medicine in China during this time developed new characteristics that emphasized the centrality of drugs as objects of pharmacological knowledge, commodities valued by authenticity and efficacy, and embodiment of medical skills and expertise. My inquiry contributes to a deeper understanding of the materiality of healing as a basic condition in early modern societies: on the one hand, textual knowled
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Case, Olivia Hildegard. "An assessment of medicinal hemp plant extracts as natural antibiotic and immune modulation phytotherapies." Thesis, University of the Western Cape, 2005. http://etd.uwc.ac.za/index.php?module=etd&amp.

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This study aimed to evaluate the antimicrobial efficacy of medicinal hemp plant extracts to determine the antibacterial effects of indigenous Sansevieria species and exotic Cannabis sativa phytotherapy varieties. This study also assessed whether aqueous o
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Skilling, Kathryn J. "Low molecular mass nucleoside gelators for intra-tumoural drug delivery." Thesis, University of Nottingham, 2016. http://eprints.nottingham.ac.uk/33222/.

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There are numerous chemotherapeutic agents available today that treat a wide array of tumours. The majority of these compounds are administered via intravenous (i.v.) infusion in large doses (1000 mg/m2), necessary to sustain a desired therapeutic effect. The systemic nature of the drug delivery, the dosage size and non-specific nature of many chemotherapeutic agents however means that they attack any rapidly dividing tissue system, leading to the commonly observed side effects e.g. alopecia, nausea, neutropenia and thrombocytopenia. Low molecular weight gelators (LMWGs) are increasing in popu
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Parikh, Vijay. "Design and development of novel 'off the shelf' small diameter helical electrospun graft." Thesis, University of Bolton, 2016. http://ubir.bolton.ac.uk/930/.

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There is an acute clinical need for small-calibre (<6 mm) vascular grafts for surgery, but unlike their large counterparts they still fail in long-term clinical application. The failures of small diameter grafts are primarily due to the early formation of thrombosis and intimal hyperplasia. Dynamics of blood flow leading to wall shear rate and blood flow pattern and their effect on the endothelial cell proliferation along with other anomalies, have been identified as one of the major deciding factors for the efficiency of grafts. Research has showed that intimal hyperplasia and associated comp
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Chiang, Michelle. "Cardamonin induces apoptosis in human nasopharyngeal carcinoma cells via mitochondrial death pathway mediated by caspase-3 and caspase-8 activation, independent of caspase-9 signalling responses." Thesis, University of Nottingham, 2016. http://eprints.nottingham.ac.uk/32565/.

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Nasopharyngeal cancer lies in the upper part of throat behind the nose and near the base of the skull called the nasopharynx. It is more commonly diagnosed in parts of Asia, particularly in the southern China. Five local edible plants from different families; namely curry leaf (Murraya koenigii), temu kunci (Boesenbergia rotunda), spring onion leaf (Allium cepa), mushroom bean (Phaseolus vulgaris) and bunga kantan (Phaeomeria imperialis) were macerated to obtain methanol, ethyl acetate and hexane crude extracts. Each crude extract was tested against nasopharyngeal carcinoma (HK-1) and normal n
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Cruz, João Carlos Santos. "Unlocking the potential of novel taxa : a study on Actinoallomurus." Thesis, University of Warwick, 2016. http://wrap.warwick.ac.uk/81849/.

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The discovery of antibiotics has played a significant role in raising public health standards and improving the outcomes for patients with bacterial infections. Unfortunately, drug discovery efforts have not kept pace with emergence and spread of antibiotic resistance. This project is part of a discovery programme designed to assess the metabolic potential of Actinoallomurus, a recently described genus within the Actinobacteria. The schedule of work included small-scale fermentations (from 200 strains) followed by bioactivity testing. The most promising positive samples were then subjected to
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46

Thong, Li Ming. "Effect of formulation variables on insulin localisation within solid lipid nanoparticles." Thesis, University of Nottingham, 2016. http://eprints.nottingham.ac.uk/31206/.

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There has been a lot of interest on solid lipid nanoparticles (SLNs) as these colloidal submicron drug dosage forms present a promising frontier in drug delivery. It is possible to incorporate susceptible drugs such as protein intended for oral delivery. Here, we aim to develop an oral delivery system based on SLNs to deliver the peptide hormone, insulin using the double emulsion (W/O/W) solvent evaporation technique for formulating the SLNs. The choice of lipids was carefully selected to incorporate acceptability to biological milieu. The main purpose of the work was to formulate SLNs to achi
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Amekyeh, Hilda. "Formulation, gastrointestinal transit studies and absorption of amphotericin B-containing solid lipid nanoparticles in rats." Thesis, University of Nottingham, 2016. http://eprints.nottingham.ac.uk/33437/.

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Successful delivery of pharmaceuticals orally requires a firm understanding of how dosage forms behave during their passage through the gastrointestinal (GI) tract. In this study, the GI transit time and absorption of amphotericin B (AmB) solid lipid nanoparticles (SLN) were investigated in rats, using paracetamol (PAR) and sulphapyridine (SP) as indirect markers. A high encapsulation efficiency of 91.2% was obtained for the AmB SLNs. The SLNs were exhaustively characterised with regards to size, zeta potential (ZP), viscosity, density, migration propensity within agarose gel, in vitro drug re
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48

Lam, Fong Ki. "Discovery and evaluation of anti-cancer agents." Thesis, University of Nottingham, 2010. http://eprints.nottingham.ac.uk/11242/.

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Cancer is the most common cause of the human death in the UK. Every year 3.2 million Europeans are diagnosed with cancer, and the figure is projected to rise due to the aging population. Although significant advances are being made in the fight against the disease, cancer remains a key public health concern and a tremendous burden on UK society in financial and social terms. This thesis evaluated two classes of compounds that can be potentially developed as anti-cancer agents. 4-(4-Methyl-2-(methylamino)thiazol-5-yl)-2-(4-methyl-3-(morpholinosulfonyl)phenylamino)pyrimidine-5-carbonitrile (S-13
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Bayard, Fabrice J. C. "Increasing drug retention in lung tissue through conjugation with polyethylene-glycol." Thesis, University of Nottingham, 2013. http://eprints.nottingham.ac.uk/13214/.

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The pulmonary delivery of drugs is an attractive route of administration because of the large surface area and high permeability of the airway epithelium. The large majority of inhaled drugs are used to manage asthma and Chronic Obstructive Pulmonary Disorder (COPD), such as inhaled corticosteroids and β2-adrenergic receptor agonists. Local delivery of small molecules often results in sub-optimal pharmacokinetics characterised by short absorption times (tmax) and high systemic concentrations (Cmax). Numerous drug delivery strategies have been attempted to increase lung retention time, includin
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Armitage, Nolan Jennifer Claire. "Time of flight mass spectrometry of pharmaceutical systems." Thesis, University of Nottingham, 2013. http://eprints.nottingham.ac.uk/13701/.

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Time-of-flight secondary ion mass spectrometry (ToF-SIMS) is a widely used surface chemical analysis technique that is traditionally employed to characterise the first few molecular layers of a material interface. The ability of this technique to accurately reflect the surface chemistry of polymers, biomaterials and many other solid materials is well documented. However, the majority of research that utilises this technique is based upon a qualitative rather than quantitative assessment of the material under investigation. The qualitative analysis of a range of traditional tablet and bead form
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