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Dissertations / Theses on the topic 'Maternal antibodies'

Author: Grafiati

Published: 4 June 2021

Last updated: 1 February 2022

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1

Dalton, Paola. "Maternal antibodies to fetal antigens." Thesis, University of Oxford, 2002. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.270344.

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2

Poorten, Thomas J. "Maternal transfer of antibodies in Xenopus laevis." Electronic thesis, 2008. http://dspace.zsr.wfu.edu/jspui/handle/10339/174.

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3

Kim, Dhohyung. "Mechanism of Maternal Antibody Inhibition and Vaccination Strategies in the presence of Maternal Antibodies." The Ohio State University, 2012. http://rave.ohiolink.edu/etdc/view?acc_num=osu1330968863.

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4

Coakley, Christina Marie. "Factors affecting maternal provisioning to the pre-natal environment." Thesis, University of Edinburgh, 2014. http://hdl.handle.net/1842/8896.

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Maternal effects are important mechanisms by which mothers’ may influence the phenotype of their offspring. Females may vary in the resources they can provide during offspring development and understanding the factors responsible for this variation is key to understanding offspring success- in early life as well as later life. Differential allocation has been reported to occur, however how it impacts on offspring and mother’s future reproduction still remains unclear. This is also true for maternal transferred substances like maternally transferred immunity. Contributions to date have been lim

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5

Chapman, James D. "Mathematical modelling of epidemic systems influenced by maternal antibodies and public health intervention." Thesis, University of Warwick, 2010. http://wrap.warwick.ac.uk/4513/.

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The general subject area of research considered in this thesis is population level epidemic modelling of infectious diseases, with specific application to the problems of model indeterminacy and systems that include processes associated with maternally acquired immunity. The work presents the derivation and analysis of a lumped systems model framework to study the influence of maternal antibodies on the population dynamics of infection among neonate and young infant age classes. The proposed models are defined by sets of ordinary and partial differential equations that describe the variation o

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6

Nguyen, Trang Van. "Rotavirus vaccines and impact of maternal antibodies and cytokines on neonatal immune responses in swine." Connect to resource, 2005. http://rave.ohiolink.edu/etdc/view?acc%5Fnum=osu1124135253.

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Thesis (Ph. D.)--Ohio State University, 2005.<br>Title from first page of PDF file. Document formatted into pages; contains xxv, 449 p.; also includes graphics (some col.). Includes bibliographical references (p. 376-449). Available online via OhioLINK's ETD Center

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Orhan, Sahin. "Ecology of Campylobacter Colonization in Poultry: Role of Maternal Antibodies in protection and Sources of Flock Infection." The Ohio State University, 2003. http://rave.ohiolink.edu/etdc/view?acc_num=osu1047067618.

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8

Sahin, Orhan. "Ecology of Campylobacter colonization in poultry role of maternal antibodies in protection and sources of flock infection /." Columbus, OH : Ohio State University, 2003. http://rave.ohiolink.edu/etdc/view?acc%5Fnum=osu1047067618.

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Thesis (Ph. D.)--Ohio State University, 2003.<br>Title from first page of PDF file. Document formatted into pages; contains xii, 177 p.: ill. Includes abstract and vita. Advisor: Qijing Zhang, Dept. of Veterinary Preventive Medicine. Includes bibliographical references (p. 152-177).

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9

Hsu, Bobby. "Transfer and effects of maternal anti-Plasmodium antibodies in Hawai'i 'amakihi (Hemignathus virens) and common canary (Serinus canaria) /." University of Hawai'i at Hilo, 2009. http://proquest.umi.com/pqdweb?did=1937737691&sid=1&Fmt=2&clientId=23658&RQT=309&VName=PQD.

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10

Jurek, Betty [Verfasser]. "Effects of human anti-GluN1 antibodies on the offspring in a murine model of maternal antibody transfer / Betty Jurek." Berlin : Medizinische Fakultät Charité - Universitätsmedizin Berlin, 2018. http://d-nb.info/1176631942/34.

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11

Oliveira, Marília Garcia de. "Efeito modulador da imunização pré-concepcional murina com ova na maturação tímica de linfócitos Tγδ da prole com potencial modulador sobre o desenvolvimento da alergia." Universidade de São Paulo, 2017. http://www.teses.usp.br/teses/disponiveis/42/42133/tde-21022018-102547/.

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Para elucidar os mecanismos envolvidos na inibição da hipersensibilidade do tipo I em proles murinas mediada pela imunização materna com Ovalbumina (OVA), as proles foram avaliadas quanto aos linfócitos Tγδ produtores de IL-17 (CD27-). A imunização materna com OVA reduziu a expressão de CD27, o que também se refletiu nos pulmões, e a produção de IL-17 por linfócitos Tγδ das proles. A redução da expressão de CD27 também foi evidenciada em linfócitos Tγδ intratímicos das proles após a transferência passiva de anticorpos IgG alérgeno específicos para fêmeas gestantes

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12

Alonso, Galindo Selena. "Effect of maternal HIV and malaria on the transplacental transfer of antibodies against prevalent pathogens and vaccines in Mozambican women." Doctoral thesis, Universitat de Barcelona, 2021. http://hdl.handle.net/10803/672103.

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Infectious diseases are one of the main causes of mortality in newborns born in Mozambique. Transplacental transfer of antibodies is essential for conferring protection during the first months of life against these diseases. In this doctoral thesis, we have assessed the impact of maternal HIV infection and malaria during pregnancy on cord blood levels of antibodies and on the efficiency of placental transfer of IgG subclasses. The effect of other maternal factors and pregnancy outcomes has also been assessed. We have measured total IgG and IgG subclass levels in maternal and cord blood by q

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13

Hatch, Steven. "Maternally Derived Anti-Dengue Antibodies and Risk of DHF in Infants: A Case-Control Study." eScholarship@UMMS, 2010. https://escholarship.umassmed.edu/gsbs_diss/476.

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This study proposes to directly test the hypothesis that antibody-dependent enhancement (ADE) is the critical factor in the development of dengue hemorrhagic fever (DHF) in infants. DHF occurs in two distinct clinical settings: a) in children and adults with secondary DENV infection, and b) in infants with primary DENV infection born to mothers with prior DENV infection. The ADE hypothesis proposes that pre-existing serotype-cross-reactive non-neutralizing anti-DENV antibodies bind the heterotypic DENV during secondary infection and enhance its uptake into immune cells, leading to increased vi

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14

Aaltonen, Antti S. "Natural immunity in dental caries longitudinal studies of serum and salivary antibodies reactive with Streptococcus mutans in young children in relation to dental caries and some maternal factors /." Turku, Finland : University of Turku, Institute of Dentistry, 1989. http://catalog.hathitrust.org/api/volumes/oclc/20115011.html.

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15

Arnal, Audrey. "Circulation d'agents pathogènes en populations naturelles : approches éco-épidémiologiques chez le Goéland leucophée (Larus michaellis)." Thesis, Montpellier 2, 2012. http://www.theses.fr/2012MON20139/document.

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L'émergence des zoonoses est à relier directement avec les perturbations générées par l'Homme sur son environnement naturel à plus ou moins grande échelle. Sur l'ensemble des zoonoses émergentes chez l'Homme, la majorité provient d'animaux sauvages. L'étude du rôle de la faune sauvage dans la circulation des agents pathogènes est donc cruciale en particulier quand les interfaces faune sauvage/Homme sont fortes. L'objectif de cette thèse a été de comprendre par des approches éco-épidémiologiques à large échelle, la circulation d'agents pathogènes dans les populations d'un oiseau sauvage en cont

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Ramos, Juliana Uehara. "Bronquite infecciosa aviária : sorologia em região sem vacinação compulsória /." Araçatuba, 2017. http://hdl.handle.net/11449/151425.

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Orientador: Tereza Cristina Cardoso Silva<br>Banca: Roberto Gameiro de Carvalho<br>Banca: Andréa Fontes Garcia<br>Resumo: O Vírus da Bronquite Infecciosa, assim como outras doenças infecciosas, é um dos principais limitantes à produção de frango de corte. O coronavírus responsável por causar essa doença influencia na perda de desempenho das aves acometidas prejudicando o perfil financeiro do setor. Considerando o Brasil hoje, o segundo maior exportador mundial de carne de frango e esse coronavírus altamente contagioso por suas perdas em níveis financeiro e industrias, este trabalho objetivou a

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17

Zhu, Jing. "The modulation of autoimmune disease progression in mouse models." Diss., Virginia Tech, 2020. http://hdl.handle.net/10919/100945.

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B cells play crucial roles in the development of the two human autoimmune diseases, type 1 diabetes (T1D) and systemic lupus erythematosus (SLE). In the past decade, numerous studies showed positive responses of B cell depletion therapies in these two diseases. However, the beneficial effects are temporary and accompanied with adverse events. In this dissertation, we aimed to identify novel targets for a better modulation of disease development using mouse models. These diseases have circulating autoantibodies that are mostly mutated with an IgG isotype, indicating B cells that are producing t

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Brasil, Tatiana Braga. "Transferência transplacentária de anticorpos anti-Streptococcus B nos recém-nascidos de termo e pré-termo." Universidade de São Paulo, 2008. http://www.teses.usp.br/teses/disponiveis/5/5141/tde-25082008-152728/.

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O Streptococcus do Grupo B (EGB) é um dos principais agentes de infecção no período neonatal, sendo responsável por altos índices de morbimortalidade materno-fetal. Este estudo tem por objetivo avaliar a passagem transplacentária de anticorpos anti-Streptococcus B e imunoglobulina G em recém-nascidos de termo e pré-termo, bem como comparar seus níveis séricos. Foi realizado estudo transversal incluindo 44 recém-nascidos (18 pré-termo e 26 de termo) do Berçário Anexo à Maternidade do Hospital das Clínicas da FMUSP no período de dezembro de 2006 a julho de 2007. Após consentimento esclarecido, f

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Recknagel, Stephan. "Seroprävalenz von Tetanustoxoid-Antikörpern bei Pferden in Mitteldeutschland und Evaluierung ihrer Bestimmung mittels eines immunchromatographischen Schnelltestes." Doctoral thesis, Universitätsbibliothek Leipzig, 2015. http://nbn-resolving.de/urn:nbn:de:bsz:15-qucosa-189143.

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Trotz der längst etablierten und weit verbreiten Impfprophylaxe mit potenten Toxoidimpfstoffen sind dramatisch verlaufende Tetanusinfektionen noch immer im Alltag des Pferdepraktikers präsent. Dies gab Anlass, verschiedene Impfprotokolle und die daraus resultierende humorale Immunitätslage zu überprüfen. Kenntnis über die durch Vakzination erwirkte Tetanusimmunität ist im Falle der Versorgung von Verletzungen oder vor elektiven Eingriffen hinsichtlich der Entscheidung für oder gegen eine neuerliche aktive und/oder passive Immunisierung erforderlich. Weiterhin ermöglicht die Kontrolle auf Persi

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20

Pereira, Catherine. "Kinetics of inhaled antibodies by gamma scintigraphy." Thesis, University of Nottingham, 2013. http://eprints.nottingham.ac.uk/30444/.

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Inhalation represents a potentially attractive delivery route for biologics, especially those designed to treat pulmonary diseases such as asthma, cystic fibrosis or lung cancer. Delivery directly to the site of action should increase local concentrations of drug, whilst reducing systemic side effects. However, there is limited knowledge regarding the mechanisms of pulmonary clearance, with gaps in understanding; where molecules are absorbed, the mechanisms involved, regional variability throughout the lung, and how to control pulmonary retention and/or facilitate cellular uptake. The work pre

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21

Smith, Richard Gary. "The regulation of peptide mimotope/epitope recognition by monoclonal antibodies." Thesis, University of Nottingham, 2002. http://eprints.nottingham.ac.uk/10053/.

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Protein-based therapeutics play an increasingly important role in medicine, and the exquisite bio-recognition properties exhibited by antibodies has also led the their use in a number of other fields apart from medicine. The increasing use of these molecules requires more efficient methods of purification. A review of the current purification strategies was conducted. Of all the purification methods studied, peptide epitope/mimotope affinity chromatography proved to be the method of choice - resulting in antibodies exhibiting high specific immunoreactivity. The need to tailor unique affinity l

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22

Addison, BriAnne Ashley. "Maternally derived antibodies in avian eggs and offspring ecology, life history, and development /." Diss., St. Louis, Mo. : University of Missouri--St. Louis, 2009. http://etd.umsl.edu/r3961.

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23

Langel, Stephanie Mary Neal. "Defining the Gut-Mammary Gland-Secretory IgA Axis in Porcine Epidemic Diarrhea Virus Infected Gilts and its Impact on Lactogenic Immune Protection of Neonatal Suckling Piglets." The Ohio State University, 2018. http://rave.ohiolink.edu/etdc/view?acc_num=osu1542041868304033.

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24

Sleeman, Karen. "Characterising pneumococcal carriage and the role of maternally derived pneumococcal antibodies in infants less than 6 months of age." Thesis, University of Oxford, 2001. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.393978.

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25

Muniz, Bruno Pacola. "Efeito da imunização materna com Ovalbumina na ativação de células dendríticas e geração de linfócitos T reguladores na prole de camundongos." Universidade de São Paulo, 2011. http://www.teses.usp.br/teses/disponiveis/42/42133/tde-20032012-161225/.

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A predisposição genética associada à predisposição dos neonatos em gerar uma resposta do tipo Th2 ao alérgeno pode favorecer o desenvolvimento de alergia no período neonatal. O presente projeto tem como proposta investigar os mecanismos regulatórios decorrentes da imunização com ovalbumina pré-concepção na resposta IgE da prole. A imunização materna transfere intensamente anticorpos à prole pelas vias placentária e da amamentação. Além disto, a imunização materna é capaz de inibir o desenvolvimento da resposta IgE da prole, aumentar a expressão de CD80 nas células dendríticas (DCs) da prole e

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Maranho, Caroline Klein. "Prevalência de anticorpos irregulares em gestantes atendidas em serviços públicos da hemorrede de Santa Catarina." Universidade de São Paulo, 2017. http://www.teses.usp.br/teses/disponiveis/17/17155/tde-07062017-145049/.

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A doença hemolítica perinatal (DHPN) é caracterizada pela destruição das hemácias fetais por anticorpos da classe IgG presentes na circulação materna. Esses anticorpos, dirigidos contra antígenos eritrocitários presentes nas hemácias do feto, atravessam a barreira placentária e promovem a hemólise prematura dos eritrócitos, podendo levar à anemia fetal. O presente trabalho teve como objetivo principal determinar a prevalência dos anticorpos irregulares em gestantes atendidas em maternidades públicas da hemorrede de Santa Catarina por meio de um estudo observacional, com coorte retrospectiva, e

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Sparks, Alexandra Megan. "Evolutionary genetics of immunity to helminths in wild Soay sheep." Thesis, University of Edinburgh, 2018. http://hdl.handle.net/1842/31109.

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Parasites have a major impact on host condition and fitness and thereby represent a strong selective force for individuals in wild populations. The main defence against parasite infection and associated morbidity is the host immune response, and consequently it is expected for there to be strong selection eroding genetic variation underlying immune responses in natural populations. However, studies in the wild have found considerable heritable variation underlying immune responses. Few studies have investigated the genetic variants underlying immunity in wild populations and are able to examin

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ARAUJO, EMERSON A. de. "Separacao de radioimunoensaios em fase magnetica, com particulas preparadas no IPEN e sua comparacao com as metodologias convencionais." reponame:Repositório Institucional do IPEN, 1991. http://repositorio.ipen.br:8080/xmlui/handle/123456789/10250.

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Made available in DSpace on 2014-10-09T12:36:31Z (GMT). No. of bitstreams: 0<br>Made available in DSpace on 2014-10-09T13:59:25Z (GMT). No. of bitstreams: 1 04132.pdf: 2205877 bytes, checksum: acad778365e22c1171a5abf7b55b03f2 (MD5)<br>Tese (Doutoramento)<br>IPEN/T<br>Instituto de Pesquisas Energeticas e Nucleares - IPEN/CNEN-SP

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Victor, Jefferson Russo. "Mecanismos regulatórios mediados pelos anticorpos maternos na modulação da resposta de hipersensibilidade do tipo I ao alérgeno ovalbumina em camundongos neonatos." Universidade de São Paulo, 2008. http://www.teses.usp.br/teses/disponiveis/42/42133/tde-25032009-171427/.

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Avaliamos os mecanismos regulatórios desencadeados pela imunização materna na resposta alérgica da prole OVA. A imunização materna com OVA promoveu alterações como o aumento da expressão dos receptores FcgRIIb nos linfócitos B esplênicos dos neonatos aos 3 dias de idade (d.i.), o que se manteve até os 20 d.i. Com a imunização das proles no período neonatal a imunização materna inibiu a produção de anticorpos IgE anti-OVA. Além disso, foi observado na população de linfócitos B da prole o aumento da expressão dos receptores FcgRIIb e CD44. A transferência passiva de IgG de mães imunes no pós-nat

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Marques, Ana Lúcia Silveira Lessa. "Aquisição passiva de anticorpos IgG maternos reativos com os lipopolissacarídeos de enterobactérias incidentes em infecções neonatais por recém-nascidos pré-termos e a termo." Universidade de São Paulo, 2009. http://www.teses.usp.br/teses/disponiveis/42/42135/tde-16072009-152507/.

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As espécies Klebsiella pneumoniae, Escherichia coli e Pseudomonas aeruginosa são responsáveis por infecções neonatais hospitalares. Lipopolissacarídeo (LPS) é o principal indutor de respostas inflamatórias. Os objetivos foram avaliar a transferência placentária de IgG reativa ao LPS de K. pneumoniae, E. coli O111, O26 e O6 e P. aeruginosa empregando ELISA para dosar IgG em soro materno e de cordão de 29 neonatos pré-termos e 32 a termo; analisar IgM total e específica no soro materno; e investigar a influência das patologias apresentadas pelas mães na transferência placentária. Concentrações d

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Thenin, Suzie. "Transmission mère-enfant du virus de l'immunodéficnece humaine de type 1 : rôle des anticorps neutralisants maternels et propriétés biologiques des virus transmis." Thesis, Tours, 2012. http://www.theses.fr/2012TOUR3305/document.

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La transmission mère-enfant (TME) est un modèle naturel permettant d’explorer le rôle des anticorps neutralisants dans la protection vis-à-vis de l’infection par le VIH-1 ainsi que les caractéristiques des virus transmis aux enfants malgré la présence d’anticorps maternels. Au cours de mes travaux, nous avons confirmé l’importance de la région V2 de la glycoprotéine de surface (gp120) du VIH-1 dans la résistance du virus à la neutralisation. L’analyse des propriétés de variants transmis à l’enfant et de variants maternels a mis en évidence une grande hétérogénéité de leurs propriétés biologiqu

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Vaca, Silvia Patricia Nuñes. "Transferência de anticorpos reativos com intiminas α, β, γ de Escherichia coli pela placenta e aleitamento materno: determinação quantitativa em soros de recém-nascidos e soros e colostros de suas mães." Universidade de São Paulo, 2010. http://www.teses.usp.br/teses/disponiveis/9/9136/tde-19012011-100807/.

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Intimina é uma adesina de natureza protéica das bactérias diarreiogênicas Escherichia coli enteropatogenica (EPEC) e enterohemorrágica (EHEC), capazes de induzir a lesão \'attaching e effacing\' em enterócitos. Os principais subtipos de intiminas de EPEC e EHEC prevalentes no Brasil são α, β e γ. Nosso objetivo foi investigar a transferência de anticorpos maternos anti-intiminas aos recém-nascidos de mães saudáveis de São Paulo, Brasil. Foram pesquisados anticorpos SIgA no colostro e IgG no soro de 50 mulheres saudáveis e no soro de cordão umbilical de seus recém-nascidos, por E

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Amaral, Daphne Renata Tavares. "Determinação do genótipo RHD fetal através do plasma materno em gestantes RhD-negativo de uma população do Brasil." [s.n.], 2010. http://repositorio.unicamp.br/jspui/handle/REPOSIP/310413.

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Orientador: Lilian Maria de Castilho<br>Dissertação (mestrado) - Universidade Estadual de Campinas, Faculdade de Ciências Médicas<br>Made available in DSpace on 2018-08-16T19:56:37Z (GMT). No. of bitstreams: 1 Amaral_DaphneRenataTavares_M.pdf: 1431812 bytes, checksum: 82f80c8b6c347220a22a8345ee9be187 (MD5) Previous issue date: 2010<br>Resumo: A análise de plasma materno para a determinação do genótipo RHD fetal é uma importante ferramenta no acompanhamento de gestantes RhD-negativo, especialmente em pacientes aloimunizadas. Este trabalho verificou a acurácia da genotipagem RHD fetal pela aná

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Cardoso, Elaine Cristina. "Avaliação da transferência materno-infantil de anticorpos séricos e secretores dirigidos ao polissacarídeo da cápsula de Haemophilus influenzae tipo B (HIB) em amostras pré e pós-vacinais de mães com PRP conjugado ao toxóide tetânico (PRP-T)." Universidade de São Paulo, 2008. http://www.teses.usp.br/teses/disponiveis/42/42133/tde-17092008-112422/.

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Introdução: O Haemophilus influenzae type b (Hib) é a primeira maior causa de meningites e pneumonias provocadas por bactérias encapsuladas. Trabalhos revelam que anticorpos maternos, séricos e secretores, podem proteger recém nascidos (RN) destes patógenos encapsulados e contribuem para a maturação do sistema imune do infante. Objetivo: O presente estudo teve como objetivo investigar a transferência materno-infantil de anticorpos anti-Hib em mães vacinadas e que não receberam a vacina anti-Hib. Materiais e Métodos: Nós avaliamos 29 mulheres saudáveis, das quais 13 foram vacinadas e 16 não rec

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Souza, Camila Lucas de. "Custo do teste Anti-HBs pós-vacinação primária em relação ao manejo para hepatite B pós-exposição à material biológico entre trabalhadores da área da saúde." Universidade Federal de Goiás, 2018. http://repositorio.bc.ufg.br/tede/handle/tede/8669.

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Bhanot, Anisha. "Maternal antibodies in autism: what is known and future directions." Thesis, 2018. https://hdl.handle.net/2144/30896.

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Autism spectrum disorder (ASD) refers to a highly prevalent neuropsychiatric disorder, currently affecting one in every 68 children. ASD is understood as a heterogeneous disorder, and individuals with this condition vary considerably in terms of symptom presentation. This heterogeneity contributes to the difficulty faced by researchers and clinicians in trying to determine the precise underlying mechanisms and treatment for this condition. Furthermore, it remains unknown whether the variations in symptom manifestation are attributed to differences in underlying etiologies of the disorder or ot

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Hung, Chia-Liang, and 洪嘉良. "Effect of different level of maternal antibodies against Haemophilus parasuis in piglets." Thesis, 2018. http://ndltd.ncl.edu.tw/handle/fnts3f.

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碩士<br>國立屏東科技大學<br>獸醫學系所<br>106<br>Haemophilus parasuis (Hps) is a commensal organism of the upper respiratory tract of conventional pigs that causes Glässer’s disease, which is characterized by fibrinous polyserositis, polyarthritis, and meningitis. This disease causes significant economic losses in the swine industry worldwide due to its high mortality and morbidity rates. However, disease prevalence may modulated by concomitant stressors and level of maternal antibodies. Therefore, the aim of this study is to analyze the impact of maternal antibodies and cortisol in the infection of Hps on p

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GUAN, ZHI-REN, and 關智仁. "Studies on maternal antibodies and its role in vaccination programs against Newcastle disease." Thesis, 1989. http://ndltd.ncl.edu.tw/handle/52013605872182979570.

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Liu, Hung, and 劉鴻. "Evaluation of the efficacy and vaccination programs of porcine reproductive and respiratory syndrome modified-live virus (PRRS-MLV) vaccine on piglets with different level of maternal antibodies." Thesis, 2017. http://ndltd.ncl.edu.tw/handle/jqwan9.

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碩士<br>國立屏東科技大學<br>獸醫學系所<br>106<br>Porcine reproductive and respiratory syndrome virus cause huge economic losses in swine industry. Studies have shown that pigs received PRRS MLV significantly reduces respiratory lesions, virus load and improved growth performance following PRRSV challenge. However, the better program of PRRS modified-live virus (PRRS-MLV) vaccination on piglets with different level of maternal antibodies is still unknown. Therefore, the aim of the study is to evaluate the efficacy and the vaccination programs of the PRRS MLV vaccine on piglets under field condition. Sows was

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Ramahefarisoa, Rondro M. "Facteurs influençant la réponse immunitaire humorale suite à la vaccination avec un vaccin vivant contre la maladie de Gumboro chez le poulet de chair." Thèse, 2011. http://hdl.handle.net/1866/5750.

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Au Québec, l’abattage des poulets se fait entre 33 et 40 jours. Pour permettre cet abattage, les poulets devront être vaccinés en présence d’anticorps maternels puisque la période d’attente après la vaccination est de 21 jours. L’objectif de cette étude a été de déterminer l’efficacité d’une forte dose de vaccin et de vitamine E à contourner les anticorps maternels et à vacciner par contact les poulets non vaccinés. Des vaccins à dose normale de 104,35 TCID50/ml/oiseau et à forte dose de 105,35 TCID50/ml/oiseau ont été utilisées sur 1200 poulets repartis en 4 groupes; (1) FD100%, groupe dans l

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Bairos, Jéssica Chaves Braga. "Production and purification of anti-human interleukin- 8 monoclonal antibodies." Master's thesis, 2019. http://hdl.handle.net/10773/30141.

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Over the past few years, monoclonal antibodies (mAbs) have gained interest as alternative therapy. In particular, anti-interleukin-8 (anti-IL-8) mAbs have shown high potential for the treatment of inflammatory diseases, since they reduce neutrophil infiltration in the early stage of inflammation. However downstream processing has not evolved at the same rate as upstream, being considered the limiting and most costly step in the production of these biopharmaceuticals. The conventional platform adopted for the purification of IgG, counts on a primary antibody capture step by protein A aff

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Hardy, Gregory. "Model Membranes Study the Lipid-Reactivity of HIV-1 Antibodies and Vaccine Antigen." Diss., 2014. http://hdl.handle.net/10161/8711.

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<p>One promising HIV-1 vaccine target is the membrane-proximal external region (MPER) of viral gp41. MPER is poorly immunogenic, however, the two rare neutralizing antibodies (NAbs), 2F5 and 4E10, bind to MPER with great neutralizing ability. Although their neutralizing mechanism represents a promising framework for the design of new HIV-1 liposomal vaccine candidates, this mechanism remains poorly understood. It is known that 2F5 and 4E10 are required to first associate with HIV-1 lipids before binding to the target MPER antigen, however, little is known about how lipid membranes contribute t

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Chen, Hung-Wei, and 陳虹瑋. "Cell and molecular mechanism study of cancer targeting materials: 1. The mechanism of cancer cell death for multi-photon triggered target-based nanodiamonds; 2. Application of single domain antibodies (anti-HER-2 and anti-CEACAM6) in breast cancer targeti." Thesis, 2011. http://ndltd.ncl.edu.tw/handle/22633139499959438731.

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碩士<br>國立交通大學<br>生物科技學系<br>99<br>Targeted cancer therapy is more effective than conventional treatments and less harmful to normal cells. In this study, we have combined nanotechnology and biotechnology to develop a novel cancer cell targeting therapy. Growth factor are autocines, will be overexpressed in varies tumors. We expressed recombinant green fluorescence protein (GFP) and growth hormone receptor binding protein (GHRBP) which could specify recognize growth hormone receptor (GHR) which is located on cell surface of the non-small cell lung cancer cells line, A549. By conjugated with carb

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