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Journal articles on the topic 'Maternal exposure to metals'

Author: Grafiati

Published: 11 December 2022

Last updated: 31 July 2025

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1

Callan, A. C., A. L. Hinwood, M. Ramalingam, et al. "Maternal exposure to metals—Concentrations and predictors of exposure." Environmental Research 126 (October 2013): 111–17. http://dx.doi.org/10.1016/j.envres.2013.07.004.

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Choi, Sohyeon, Aram Lee, Gyuyeon Choi, et al. "Free Cortisol Mediates Associations of Maternal Urinary Heavy Metals with Neonatal Anthropometric Measures: A Cross-Sectional Study." Toxics 10, no. 4 (2022): 167. http://dx.doi.org/10.3390/toxics10040167.

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Prenatal exposure to heavy metals is known to be associated with adverse birth outcomes and oxidative stress biomarkers. In this study, we examined whether maternal free cortisol or 8-Hydroxy-2-Deoxyguanosine (8-OHdG) could mediate associations between maternal heavy metal exposure and birth outcomes. A total of 182 healthy pregnant women were recruited. Heavy metals (including Pb, Hg, and Cd), free-cortisol, and 8-OHdG were analyzed in urine at delivery. Birth outcomes including birth weight, length, Ponderal index, and head circumference were measured. To examine associations of maternal uri

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Koh, Eun Jung, So Yeon Yu, Seung Hwan Kim, Ji Su Lee, and Seung Yong Hwang. "Prenatal Exposure to Heavy Metals Affects Gestational Age by Altering DNA Methylation Patterns." Nanomaterials 11, no. 11 (2021): 2871. http://dx.doi.org/10.3390/nano11112871.

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Environmental exposure is known to have toxic effects. Maternal environmental exposure not only affects mothers but also their fetuses in utero, which may interrupt their early development. Preterm birth, one of the outcomes of prenatal exposure, is a significant factor in lifelong health risks. To understand the effects of prenatal exposome on preterm birth, we studied the association between maternal and prenatal heavy metal exposure and gestational age, using resources from the MOthers’ and Children’s Environmental Health (MOCEH) study in South Korea. Additionally, a methylation assay was p

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GUAN, Huai, Feng-Yuan PIAO, Xiao-Wei LI, Qiu-Juan LI, Lei XU, and Kazuhito YOKOYAMA. "Maternal and Fetal Exposure to Four Carcinogenic Environmental Metals." Biomedical and Environmental Sciences 23, no. 6 (2010): 458–65. http://dx.doi.org/10.1016/s0895-3988(11)60008-1.

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Chae, JungMi, and Hyun Kyoung Kim. "Birth cohort effects on maternal and child environmental health: a systematic review." Korean Journal of Women Health Nursing 27, no. 1 (2021): 27–39. http://dx.doi.org/10.4069/kjwhn.2021.03.12.

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Purpose: This study aimed to review recent findings from birth cohort studies on maternal and child environmental health.Methods: Birth cohort studies regarding environmental health outcomes for mothers and their children were investigated through a systematic review. A literature search was conducted in PubMed, CINAHL, the Cochrane Library, Embase, and RISS to identify published studies using the keywords “((“Maternal Exposure”[Mesh] OR (“C”[TW] OR “Maternal Exposures” OR “Prenatal Exposures”[TW])) AND “Environmental Exposure”[Mesh] AND “Health”[Mesh] AND (“Cohort Studies”[Mesh] OR “Cohort”[T

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6

Nozadi, Sara S., Li Li, Li Luo, et al. "Prenatal Metal Exposures and Infants’ Developmental Outcomes in a Navajo Population." International Journal of Environmental Research and Public Health 19, no. 1 (2021): 425. http://dx.doi.org/10.3390/ijerph19010425.

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Early-life exposure to environmental toxicants can have detrimental effects on children’s neurodevelopment. In the current study, we employed a causal modeling framework to examine the direct effect of specific maternal prenatal exposures on infants’ neurodevelopment in the context of co-occurring metals. Maternal metal exposure and select micronutrients’ concentrations were assessed using samples collected at the time of delivery from mothers living across Navajo Nation with community exposure to metal mixtures originating from abandoned uranium mines. Infants’ development across five domains

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Puttabyatappa, Muraly, Margaret Banker, Lixia Zeng, et al. "Maternal Exposure to Environmental Disruptors and Sexually Dimorphic Changes in Maternal and Neonatal Oxidative Stress." Journal of Clinical Endocrinology & Metabolism 105, no. 2 (2019): 492–505. http://dx.doi.org/10.1210/clinem/dgz063.

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Abstract Context Early pregnancy exposure to endocrine disrupting chemicals (EDCs) may contribute to poor birth outcomes through oxidative stress (OS)-mediated disruption of the maternal and fetal milieu. Most studies have investigated the effect of single EDC exposures on OS. Objective Assess the association of uniquely weighted mixtures of early pregnancy exposures with the maternal and neonatal OS markers. Design Prospective analysis of mother–infant dyads Setting University hospital. Participants 56 mother–infant dyads. Main Outcome Measures The association of OS markers (nitrotyrosine, di

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Sun, Xiaojie, Wenyu Liu, Bin Zhang, et al. "Maternal Heavy Metal Exposure, Thyroid Hormones, and Birth Outcomes: A Prospective Cohort Study." Journal of Clinical Endocrinology & Metabolism 104, no. 11 (2019): 5043–52. http://dx.doi.org/10.1210/jc.2018-02492.

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AbstractContextMaternal thyroid hormones during pregnancy play a critical role in fetal development. However, whether maternal heavy metal exposure affects their thyroid hormones and the effects on fetal growth are still unclear.ObjectiveTo explore the effect of heavy metal exposure on maternal thyroid hormones and the potential mediation role of thyroid hormones on birth outcomes.MethodsConcentrations of heavy metals in urine samples and thyroid hormones in blood samples of 675 pregnant women were measured during early pregnancy in a cohort study conducted in China. Multivariable linear regre

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9

Luu, Thi Ha, Gege Ma, Ming Jin, et al. "Accumulation of Mixed Heavy Metals in Maternal Hair and Risk of Pre-Eclampsia: A Prospective Nested Case–Control Study." Toxics 13, no. 7 (2025): 575. https://doi.org/10.3390/toxics13070575.

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Heavy metals (lead [Pb], cadmium [Cd], arsenic [As], mercury [Hg], manganese [Mn], copper [Cu], zinc [Zn], and iron [Fe]) might be risk factors for pre-eclampsia (PE), whereas their joint effect remains unclear. To address this issue, we conducted a nested case–control study consisting of 49 PE cases and 329 controls from a Chinese prospective birth cohort and divided the participants into low/high and quartile groups based on hair metal concentrations. We used logistic regression models and a weighted quantile sum (WQS) model to investigate the independent and mixed associations between these

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Miyashita, Chihiro, Yasuaki Saijo, Yoshiya Ito, et al. "Association between the Concentrations of Metallic Elements in Maternal Blood during Pregnancy and Prevalence of Abdominal Congenital Malformations: The Japan Environment and Children’s Study." International Journal of Environmental Research and Public Health 18, no. 19 (2021): 10103. http://dx.doi.org/10.3390/ijerph181910103.

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Abdominal congenital malformations are responsible for early mortality, inadequate nutrient intake, and infant biological dysfunction. Exposure to metallic elements in utero is reported to be toxic and negatively impacts ontogeny. However, no prior study has sufficiently evaluated the effects of exposure to metallic elements in utero on abdominal congenital malformations. The aim of the present study was to evaluate associations between metallic elements detected in maternal blood during pregnancy and congenital abdominal malformations. Data from participants in the Japan Environment and Child

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White, Jeffrey, Erin Kovar, Tiffany Chambers, et al. "Hypospadias Risk from Maternal Residential Exposure to Heavy Metal Hazardous Air Pollutants." International Journal of Environmental Research and Public Health 16, no. 6 (2019): 930. http://dx.doi.org/10.3390/ijerph16060930.

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Objective: Investigate whether residential prenatal exposure to heavy metal hazardous air pollutants (HMHAPs) is associated with an increased risk of hypospadias. Methods: Data on non-syndromic hypospadias cases (n = 8981) and control patients delivered in Texas were obtained from the Texas Birth Defects Registry and matched 1:10 by birth year. Average exposure concentrations of HMHAPs were obtained from the 2005 U.S. Environmental Protection Agency National-Scale Air Toxics Assessment and categorized into quintiles. Odds ratios and 95% confidence intervals were estimated. STROBE reporting gui

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Dorea, José G. "Mercury and lead during breast-feeding." British Journal of Nutrition 92, no. 1 (2004): 21–40. http://dx.doi.org/10.1079/bjn20041163.

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Hg and Pb are of public health concern due to their toxic effects on vulnerable fetuses, persistence in pregnant and breast-feeding mothers, and widespread occurrence in the environment. To diminish maternal and infant exposure to Hg and Pb, it is necessary to establish guidelines based on an understanding of the environmental occurrence of these metals and the manner in which they reach the developing human organism. In the present review, environmental exposure, acquisition and storage of these metals via maternal–infant interaction are systematically presented. Though Hg and Pb are disperse

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T, Tsai, and Wang S. "Maternal Exposure to Metals Associated with Increased Cord Blood Immunoglobulin E." Environmental Epidemiology 3 (October 2019): 400. http://dx.doi.org/10.1097/01.ee9.0000610472.00306.55.

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14

Tsuchiya, Hironobu, Shogo Shima, Hideki Kurita, et al. "Effects of maternal exposure to six heavy metals on fetal development." Bulletin of Environmental Contamination and Toxicology 38, no. 4 (1987): 580–87. http://dx.doi.org/10.1007/bf01608589.

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Istvan, M., R. Rahban, B. Dananche, et al. "Maternal occupational exposure to endocrine-disrupting chemicals during pregnancy and semen parameters in adulthood: results of a nationwide cross-sectional study among Swiss conscripts." Human Reproduction 36, no. 7 (2021): 1948–58. http://dx.doi.org/10.1093/humrep/deab034.

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Abstract STUDY QUESTION Is there a relationship between maternal occupational exposure to endocrine-disrupting chemicals (EDCs) during pregnancy and the semen quality of their sons? SUMMARY ANSWER Our results suggest an association between maternal occupational exposure to potential EDCs, especially to pesticides, phthalates and heavy metals, and a decrease in several semen parameters. WHAT IS KNOWN ALREADY Sexual differentiation, development and proper functioning of the reproductive system are largely dependent on steroid hormones. Although there is some animal evidence, studies on maternal

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Huang, Hui, Yongyue Wei, Yankai Xia, et al. "Child marriage, maternal serum metal exposure, and risk of preterm birth in rural Bangladesh: evidence from mediation analysis." Journal of Exposure Science & Environmental Epidemiology 31, no. 3 (2021): 571–80. http://dx.doi.org/10.1038/s41370-021-00319-3.

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Abstract Background The prevalence of preterm birth in Bangladesh is estimated to be 19.1%, the highest in the world. Although prenatal exposure to several metals has been linked with preterm birth, fewer prospective studies have investigated the socioeconomic factors that affect metal exposure, leading to preterm birth risk. Objective We aim to identify novel metal biomarkers and their critical exposure windows, as well as the upstream socioeconomic risk factors for preterm birth in rural Bangladeshi, to shed light for future interventional strategies. Methods This study included data from 78

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Hinwood, A. L., A. Stasinska, A. C. Callan, et al. "Maternal exposure to alkali, alkali earth, transition and other metals: Concentrations and predictors of exposure." Environmental Pollution 204 (September 2015): 256–63. http://dx.doi.org/10.1016/j.envpol.2015.04.024.

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18

de Assis Araujo, Mônica Seefelder, Carmen Ildes Rodrigues Froes-Asmus, Nataly Damasceno de Figueiredo, et al. "Prenatal Exposure to Metals and Neurodevelopment in Infants at Six Months: Rio Birth Cohort Study of Environmental Exposure and Childhood Development (PIPA Project)." International Journal of Environmental Research and Public Health 19, no. 7 (2022): 4295. http://dx.doi.org/10.3390/ijerph19074295.

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The PIPA Project is a prospective birth cohort study based in Rio de Janeiro, Brazil, whose pilot study was carried out between October 2017 and August 2018. Arsenic (As), cadmium (Cd), lead (Pb), and mercury (Hg) concentrations were determined in maternal (n = 49) and umbilical cord blood (n = 46). The Denver Developmental Screening Test II (DDST-II) was applied in 50 six-month-old infants. Metals were detected in 100% of the mother and newborn samples above the limits of detection. Maternal blood lead concentrations were higher in premature newborns (GM: 5.72 µg/dL; p = 0.05). One-third of t

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Shirai, Sayaka, Yayoi Suzuki, Jun Yoshinaga, and Yoshifumi Mizumoto. "Maternal exposure to low-level heavy metals during pregnancy and birth size." Journal of Environmental Science and Health, Part A 45, no. 11 (2010): 1468–74. http://dx.doi.org/10.1080/10934529.2010.500942.

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Takeuchi, Masato, Satomi Yoshida, Chihiro Kawakami, Koji Kawakami, and Shuichi Ito. "Association of maternal heavy metal exposure during pregnancy with isolated cleft lip and palate in offspring: Japan Environment and Children’s Study (JECS) cohort study." PLOS ONE 17, no. 3 (2022): e0265648. http://dx.doi.org/10.1371/journal.pone.0265648.

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Background Cleft lip and palate (cleft L/P) is one of the most common congenital anomalies and its etiology is assumed to be multifactorial. Recent epidemiological data involving a small number of participants suggested an association between perinatal exposure to heavy metals and cleft L/P in affected children. However, this association requires further investigation in a large cohort. Methods This nested case–control study used a dataset of The Japan Environment and Children’s Study, which is an ongoing research project to investigate the association between environmental factors and mother-

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Goodrich, Jaclyn M., Mary E. Ingle, Steven E. Domino, et al. "First trimester maternal exposures to endocrine disrupting chemicals and metals and fetal size in the Michigan Mother–Infant Pairs study." Journal of Developmental Origins of Health and Disease 10, no. 4 (2019): 447–58. http://dx.doi.org/10.1017/s204017441800106x.

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AbstractExposures to endocrine disrupting chemicals and metals are near ubiquitous worldwide, and their potential impact on children is a major public health concern. This pilot study was designed to characterize exposures to phthalates, phenols and metals among pregnant women in the first trimester, and to examine associations with fetal biometrics and birth weight. A total of 41 chemicals and elements were analyzed in urine from 56 mothers with full-term newborns from the Michigan Mother–Infant Pairs study. Bivariate analyses identified predictors of exposure biomarkers. Associations between

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Stoccoro, Andrea, Vanessa Nicolì, Fabio Coppedè, et al. "Prenatal Environmental Stressors and DNA Methylation Levels in Placenta and Peripheral Tissues of Mothers and Neonates Evaluated by Applying Artificial Neural Networks." Genes 14, no. 4 (2023): 836. http://dx.doi.org/10.3390/genes14040836.

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Exposure to environmental stressors during pregnancy plays an important role in influencing subsequent susceptibility to certain chronic diseases through the modulation of epigenetic mechanisms, including DNA methylation. Our aim was to explore the connections between environmental exposures during gestation with DNA methylation of placental cells, maternal and neonatal buccal cells by applying artificial neural networks (ANNs). A total of 28 mother–infant pairs were enrolled. Data on gestational exposure to adverse environmental factors and on mother health status were collected through the a

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Elhassan, Yasir Hassan, Fahad Alahmadi, Emad Ali Albadawi, et al. "The Relationship Between Maternal Exposure to Endocrine-Disrupting Chemicals and the Incidence of Congenital Heart Diseases: A Systematic Review and Meta-Analysis." Metabolites 14, no. 12 (2024): 709. https://doi.org/10.3390/metabo14120709.

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Background: Congenital heart diseases are among the most common birth defects, significantly impacting infant health. Recent evidence suggests that exposure to endocrine-disrupting chemicals may contribute to the incidence of congenital heart diseases. This study systematically reviews and analyzes the association between maternal endocrine-disrupting chemicals exposure and congenital heart diseases. Methodology: This systematic review and meta-analysis followed the Cochrane Handbook and PRISMA guidelines. We included studies assessing the link between maternal exposure to various endocrine-di

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Gonzalez-Nahm, Sarah, Kiran Nihlani, John S. House, Rachel L. Maguire, Harlyn G. Skinner, and Cathrine Hoyo. "Associations between Maternal Cadmium Exposure with Risk of Preterm Birth and Low Birth Weight: Effect of Mediterranean Diet Adherence on Affected Prenatal Outcomes." Toxics 8, no. 4 (2020): 90. http://dx.doi.org/10.3390/toxics8040090.

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Prenatal cadmium exposure at non-occupational levels has been associated with poor birth outcomes. The intake of essential metals, such as iron and selenium, may mitigate cadmium exposure effects. However, at high levels, these metals can be toxic. The role of dietary patterns rich in these metals is less studied. We used a linear and logistic regression in a cohort of 185 mother–infant pairs to assess if a Mediterranean diet pattern during pregnancy modified the associations between prenatal cadmium exposure and (1) birth weight and (2) preterm birth. We found that increased cadmium exposure

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Michelsen-Correa, Stephani, Clyde F. Martin, and Andrea B. Kirk. "Evaluation of Fetal Exposures to Metals and Metalloids through Meconium Analyses: A Review." International Journal of Environmental Research and Public Health 18, no. 4 (2021): 1975. http://dx.doi.org/10.3390/ijerph18041975.

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This paper surveys the existing scientific literature on metals concentrations in meconium. We examine some 32 papers that analyzed meconium for aluminum, arsenic, barium, calcium, chromium, copper, iron, lithium, magnesium, manganese, zinc, lead, mercury, manganese, molybdenum, nickel, phosphorus, lead, antimony, selenium, tin, vanadium, and zinc. Because of the lack of detail in the statistics it is not possible to do a rigorous meta-analysis. What stands out is that almost every study had subjects with seemingly large amounts of at least one of the metals. The significance of metals in meco

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Albadawi, Emad Ali, Naweed SyedKhaleel Alzaman, Yasir Hassan Elhassan, Heba M. Eltahir, Mekky M. Abouzied, and Muayad Saud Albadrani. "The Association between Maternal Endocrine-Disrupting Chemical Exposure during Pregnancy and the Incidence of Male Urogenital Defects: A Systematic Review and Meta-Analysis." Metabolites 14, no. 9 (2024): 477. http://dx.doi.org/10.3390/metabo14090477.

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The increasing incidence of hypospadias and cryptorchidism, coupled with the widespread presence of endocrine-disrupting chemicals (EDCs), has raised concerns about the potential impact of these environmental factors on male urogenital development. This systematic review and meta-analysis aims to evaluate the association between maternal exposure to various EDCs and the risk of hypospadias and cryptorchidism. We conducted a comprehensive search of PubMed, Scopus, Web of Science, and Cochrane databases from inception until May 2024. We included case-control and cohort studies that examined the

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Menezes-Filho, José, Chrissie Carvalho, Juliana Rodrigues, et al. "Environmental Co-Exposure to Lead and Manganese and Intellectual Deficit in School-Aged Children." International Journal of Environmental Research and Public Health 15, no. 11 (2018): 2418. http://dx.doi.org/10.3390/ijerph15112418.

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Studies have demonstrated that, for urban children, dust represents the main exposure to sources of metals like lead (Pb) and manganese (Mn). We aimed to investigate the exposure to these metals and their association with intellectual deficit in children living in an industrial region. This cross-sectional study recruited volunteers from four elementary schools in the town of Simões Filho, Brazil. We evaluated 225 school-aged children (7–12 years) for blood lead (PbB) and manganese hair (MnH) and toenails (MnTn) by graphite furnace atomic absorption spectrometry. Child and maternal IQs were es

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Ashrap, Pahriya, Deborah J. Watkins, Ginger L. Milne, et al. "Maternal Urinary Metal and Metalloid Concentrations in Association with Oxidative Stress Biomarkers." Antioxidants 10, no. 1 (2021): 114. http://dx.doi.org/10.3390/antiox10010114.

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Metal exposure has been associated with a wide range of adverse birth outcomes and oxidative stress is a leading hypothesis of the mechanism of action of metal toxicity. We assessed the relationship between maternal exposure to essential and non-essential metals and metalloids in pregnancy and oxidative stress markers, and sought to identify windows of vulnerability and effect modification by fetal sex. In our analysis of 215 women from the PROTECT birth cohort study, we measured 14 essential and non-essential metals in urine samples at three time points during pregnancy. The oxidative stress

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Qiu, Liping, Weiying Shen, Chunmei Ye, et al. "Association of exposure to PM2.5-bound metals with maternal thyroid function in early pregnancy." Science of The Total Environment 810 (March 2022): 151167. http://dx.doi.org/10.1016/j.scitotenv.2021.151167.

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K, Margetaki, Vafeiadi M, Roumeliotaki T, et al. "Association between prenatal exposure to multiple metals and maternal and child thyroid hormone levels." Environmental Epidemiology 3 (October 2019): 260. http://dx.doi.org/10.1097/01.ee9.0000608760.49099.fd.

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Tabacova, Sonia, Ruth E. Little, Liudmila Balabaeva, Sonia Pavlova, and Ivan Petrov. "Complications of pregnancy in relation to maternal lipid peroxides, glutathione, and exposure to metals." Reproductive Toxicology 8, no. 3 (1994): 217–24. http://dx.doi.org/10.1016/0890-6238(94)90005-1.

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Nicoll, Rachel. "Environmental Contaminants and Congenital Heart Defects: A Re-Evaluation of the Evidence." International Journal of Environmental Research and Public Health 15, no. 10 (2018): 2096. http://dx.doi.org/10.3390/ijerph15102096.

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Congenital heart defects (CHDs) are a common birth defect of largely unknown etiology, with high fetal and neonatal mortality. A review of CHDs and environmental contaminant exposure found that meta-analyses showed only modest associations for smoking, vehicle exhaust components, disinfectant by-products and proximity to incinerators, with stronger results from the newer, larger and better quality studies masked by the typical absence of effect in older studies. Recent studies of exposure to agricultural pesticides, solvents, metals and landfill sites also showed associations. Certain contamin

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Lee, Kuen Su, Won Kee Min, Yoon Ji Choi, Jeongun Cho, Sang Hun Kim, and Hye Won Shin. "Exposure to Fine Particulate Matter (PM2.5) and Heavy Metals During the Second Trimester of Pregnancy Increases the Risk of Preeclampsia and Eclampsia: An Analysis of National Health Insurance Claims Data from South Korea." Medicina 61, no. 7 (2025): 1146. https://doi.org/10.3390/medicina61071146.

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Background and Objectives: Air pollutants have been shown to affect hypertensive disorders and placental hypoxia due to vasoconstriction, inflammation, and oxidative stress. The objective of this study was to evaluate whether high levels of maternal exposure to heavy metals during the second trimester of pregnancy are associated with an increased risk of preeclampsia and eclampsia, using national health insurance claim data from South Korea. Methods: Data on mothers and their newborns from 2016 to 2020, provided by the National Health Insurance Service, were used (n = 1,274,671). Exposure data

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Ghazi, Terisha, Pragalathan Naidoo, Rajen N. Naidoo, and Anil A. Chuturgoon. "Prenatal Air Pollution Exposure and Placental DNA Methylation Changes: Implications on Fetal Development and Future Disease Susceptibility." Cells 10, no. 11 (2021): 3025. http://dx.doi.org/10.3390/cells10113025.

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The Developmental Origins of Health and Disease (DOHaD) concept postulates that in utero exposures influence fetal programming and health in later life. Throughout pregnancy, the placenta plays a central role in fetal programming; it regulates the in utero environment and acts as a gatekeeper for nutrient and waste exchange between the mother and the fetus. Maternal exposure to air pollution, including heavy metals, can reach the placenta, where they alter DNA methylation patterns, leading to changes in placental function and fetal reprogramming. This review explores the current knowledge on p

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Bonefeld-Jørgensen, Eva. "Pregnant Inuit Women’s Exposure to Metals and Association with Fetal Growth Outcomes: ACCEPT 2010–2015." International Journal of Environmental Research and Public Health 16, no. 7 (2019): 1171. http://dx.doi.org/10.3390/ijerph16071171.

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Environmental contaminants such as heavy metals are transported to the Arctic regions via atmospheric and ocean currents and enter the Arctic food web. Exposure is an important risk factor for health and can lead to increased risk of a variety of diseases. This study investigated the association between pregnant women’s levels of heavy and essential metals and the birth outcomes of the newborn child. This cross-sectional study is part of the ACCEPT birth cohort (Adaption to Climate Change, Environmental Pollution, and dietary Transition) and included 509 pregnant Inuit women ≥18 years of age.

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Zilversmit Pao, Leah, Emily W. Harville, Jeffrey K. Wickliffe, Arti Shankar, and Pierre Buekens. "The Cumulative Risk of Chemical and Nonchemical Exposures on Birth Outcomes in Healthy Women: The Fetal Growth Study." International Journal of Environmental Research and Public Health 16, no. 19 (2019): 3700. http://dx.doi.org/10.3390/ijerph16193700.

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Metals, stress, and sociodemographics are commonly studied separately for their effects on birth outcomes, yet often jointly contribute to adverse outcomes. This study analyzes two methods for measuring cumulative risk to understand how maternal chemical and nonchemical stressors may contribute to small for gestational age (SGA). SGA was calculated using sex-specific fetal growth curves for infants of pregnant mothers (n = 2562) enrolled in the National Institute of Child Health and Human Development (NICHD) Fetal Growth Study. The exposures (maternal lead, mercury, cadmium, Cohen’s perceived

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Serreau, Raphaël, Yasmine Terbeche, and Virginie Rigourd. "Pollutants in Breast Milk: A Scoping Review of the Most Recent Data in 2024." Healthcare 12, no. 6 (2024): 680. http://dx.doi.org/10.3390/healthcare12060680.

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Perinatal exposure to pollutants, including persistent organic pollutants (POPs) and heavy metals, poses significant risks to both mothers and children, marking this period as highly vulnerable. Despite the well-acknowledged benefits of breastfeeding, there exists a gap in comprehensive understanding regarding the impact of environmental pollutants on breast milk, underscoring the critical need for this study. Our research addresses this gap by exploring the intersection of environmental health and lactation, situated within the broader ‘One Health’ concept, thus contributing a novel perspecti

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Pearce, Mark S., Lucy R. Baxter, and Louise Parker. "Paternal Occupational Exposure to Endocrine-Disrupting Chemicals as a Risk Factor for Leukaemia in Children: A Case-Control Study from the North of England." Advances in Epidemiology 2014 (July 16, 2014): 1–7. http://dx.doi.org/10.1155/2014/323189.

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Occupations with exposures to a variety of chemicals, including those thought to be potential endocrine disruptors, have been associated with an increased risk of leukaemia in offspring. We investigated whether an association exists between paternal occupations at birth involving such exposures and risk of leukaemia in offspring. Cases (n=958) were matched, on sex and year of birth, to controls from two independent sources, one other cancers, one cancer-free live births. Paternal occupations at birth were classified, using an occupational exposure matrix, as having “very unlikely,” “possible,”

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Pizent, Alica, Maja Lazarus, Jelena Kovačić, et al. "Cigarette Smoking during Pregnancy: Effects on Antioxidant Enzymes, Metallothionein and Trace Elements in Mother-Newborn Pairs." Biomolecules 10, no. 6 (2020): 892. http://dx.doi.org/10.3390/biom10060892.

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The effect of maternal smoking as a source of exposure to toxic metals Cd and Pb on superoxide dismutase (SOD) and glutathione peroxidase (GPx) activity, metallothionein (MT), Cd, Pb, Cu, Fe, Mn, Se and Zn concentrations were assessed in maternal and umbilical cord blood and placenta in 74 healthy mother-newborn pairs after term delivery. Sparse discriminant analysis (SDA) was used to identify elements with the strongest impact on the SOD, GPx and MT in the measured compartments, which was then quantified by multiple regression analysis. SOD activity was lower in maternal and cord plasma, and

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Kim, Stephani S., Xijin Xu, Yuling Zhang, et al. "Birth outcomes associated with maternal exposure to metals from informal electronic waste recycling in Guiyu, China." Environment International 137 (April 2020): 105580. http://dx.doi.org/10.1016/j.envint.2020.105580.

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Lee, Kuen Su, Won Kee Min, Yoon Ji Choi, Sejong Jin, Kyu Hee Park, and Suhyun Kim. "The Effect of Maternal Exposure to Air Pollutants and Heavy Metals during Pregnancy on the Risk of Neurological Disorders Using the National Health Insurance Claims Data of South Korea." Medicina 59, no. 5 (2023): 951. http://dx.doi.org/10.3390/medicina59050951.

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The objective of this study was to evaluate the effects of high levels of maternal exposure to ambient air pollution and heavy metals on risks of autism spectrum disorder (ASD) and epilepsy using the National Health Insurance claims data of South Korea. The data of mothers and their newborns from 2016 to 2018 provided by the National Health Insurance Service were used (n = 843,134). Data on exposure to ambient air pollutants (PM2.5, CO, SO2, NO2, and O3) and heavy metals (Pb, Cd, Cr, Cu, Mn, Fe, Ni, and As) during pregnancy were matched based on the mother’s National Health Insurance registrat

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Jagodić, Jovana, Slađan Pavlović, Slavica Borković-Mitić, et al. "Examination of Trace Metals and Their Potential Transplacental Transfer in Pregnancy." International Journal of Molecular Sciences 23, no. 15 (2022): 8078. http://dx.doi.org/10.3390/ijms23158078.

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With the ever-growing concern for human health and wellbeing, the prenatal period of development requires special attention since fetuses can be exposed to various metals through the mother. Therefore, this study explored the status of selected toxic (Pb, Cd, Ni, As, Pt, Ce, Rb, Sr, U) and essential trace metals (Mn, Co, Cu, Zn, Se) in the umbilical cord (UC) sera, maternal sera, and placental tissue samples of 92 healthy women with normal pregnancies. A further aim focuses on the potential transplacental transfer of these trace metals. Based on the obtained levels of investigated elements in

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Farías, Paulina, David Hernández-Bonilla, Hortensia Moreno-Macías, et al. "Prenatal Co-Exposure to Manganese, Mercury, and Lead, and Neurodevelopment in Children during the First Year of Life." International Journal of Environmental Research and Public Health 19, no. 20 (2022): 13020. http://dx.doi.org/10.3390/ijerph192013020.

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Lead (Pb), mercury (Hg), and manganese (Mn) are neurotoxic, but little is known about the neurodevelopmental effects associated with simultaneous prenatal exposure to these metals. We aimed to study the associations of Pb, Hg, and Mn prenatal levels (jointly and separately) with neurodevelopment in the first year of life. Methods: Pb, Hg, and Mn blood lead levels were measured in 253 pregnant women. Their offspring’s neurodevelopment was assessed through the Bayley Scale of Infant Development III® at one, three, six, and twelve months. The metals’ mean blood levels (µg/L) were Pb = 11.2, Hg =

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Fróes-Asmus, Carmen IR, Nataly Damasceno, Arnaldo Prata-Barbosa, et al. "Urban Green Spaces and Newborns Metal Concentrations in Rio de Janeiro, Brazil." Annals of Global Health 90, no. 1 (2024): 56. http://dx.doi.org/10.5334/aogh.4512.

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Background: Brazil is the largest country in South and Latin America with an accelerated urbanization process, and the city of Rio de Janeiro is the second most populous. The PIPA Cohort Project is the first prospective study investigating the effects of urban exposure to multiple pollutants on maternal–child health in Brazil. Objective: This paper describes the relationship between maternal socio-environmental conditions and newborns’ umbilical cord blood concentrations of metals (lead, arsenic, and mercury). Methods: The study population was a convenience sample of all babies born at the UFR

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Perng, Wei, Marcela Tamayo-Ortiz, Lu Tang, et al. "Early Life Exposure in Mexico to ENvironmental Toxicants (ELEMENT) Project." BMJ Open 9, no. 8 (2019): e030427. http://dx.doi.org/10.1136/bmjopen-2019-030427.

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PurposeThe Early Life Exposure in Mexico to ENvironmental Toxicants (ELEMENT) Project is a mother–child pregnancy and birth cohort originally initiated in the mid-1990s to explore: (1) whether enhanced mobilisation of lead from maternal bone stores during pregnancy poses a risk to fetal and subsequent offspring neurodevelopment; and (2) whether maternal calcium supplementation during pregnancy and lactation can suppress bone lead mobilisation and mitigate the adverse effects of lead exposure on offspring health and development. Through utilisation of carefully archived biospecimens to measure

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Lubanzi, Michael. "Influence of Environmental Factors on Embryonic Development and Fetal Programming in South Africa." International Journal of Biology 4, no. 1 (2024): 11–23. http://dx.doi.org/10.47604/ijb.2500.

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Purpose: The aim of the study was to investigate the influence of environmental factors on embryonic development and fetal programming Methodology: This study adopted a desk methodology. A desk study research design is commonly known as secondary data collection. This is basically collecting data from existing resources preferably because of its low cost advantage as compared to a field research. Our current study looked into already published studies and reports as the data was easily accessed through online journals and libraries. Findings: The study revealed compelling evidence linking vari

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Flores-Bazán, Tania, Jeannett Alejandra Izquierdo-Vega, José Antonio Guerrero-Solano, Araceli Castañeda-Ovando, Diego Estrada-Luna, and Angélica Saraí Jiménez-Osorio. "Interplay Between Vitamin D Levels and Heavy Metals Exposure in Pregnancy and Childbirth: A Systematic Review." Pathophysiology 31, no. 4 (2024): 660–79. http://dx.doi.org/10.3390/pathophysiology31040048.

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Background/Objectives: Vitamin D (VD) deficiency has been associated with increased risk of gestational disorders affecting the endocrine system, immune system, and neurodevelopment in offspring. Recent studies have focused on the interaction between toxic elements and micronutrients during pregnancy. This review analyzes the potential relationships between VD levels and heavy metals in pregnant women and their offspring. Methods: A systematic review was conducted according to PRISMA 2020 guidelines, using databases such as PubMed, ScienceDirect, Cochrane Library, and Google Scholar. Boolean o

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Liu, Tiange, Mingyu Zhang, Mohammad L. Rahman, et al. "Exposure to heavy metals and trace minerals in first trimester and maternal blood pressure change over gestation." Environment International 153 (August 2021): 106508. http://dx.doi.org/10.1016/j.envint.2021.106508.

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Martins, Mariana F., Patrícia G. Costa, and Adalto Bianchini. "Assessing multigenerational exposure to metals in elasmobranchs: Maternal transfer of contaminants in a yolk-sac viviparous species." Marine Pollution Bulletin 175 (February 2022): 113364. http://dx.doi.org/10.1016/j.marpolbul.2022.113364.

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Al-Saleh, Iman, Neptune Shinwari, Abdullah Mashhour, and Abdullah Rabah. "Birth outcome measures and maternal exposure to heavy metals (lead, cadmium and mercury) in Saudi Arabian population." International Journal of Hygiene and Environmental Health 217, no. 2-3 (2014): 205–18. http://dx.doi.org/10.1016/j.ijheh.2013.04.009.

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