Academic literature on the topic 'Matrix Scaffold'

Create a spot-on reference in APA, MLA, Chicago, Harvard, and other styles

Select a source type:

Consult the lists of relevant articles, books, theses, conference reports, and other scholarly sources on the topic 'Matrix Scaffold.'

Next to every source in the list of references, there is an 'Add to bibliography' button. Press on it, and we will generate automatically the bibliographic reference to the chosen work in the citation style you need: APA, MLA, Harvard, Chicago, Vancouver, etc.

You can also download the full text of the academic publication as pdf and read online its abstract whenever available in the metadata.

Journal articles on the topic "Matrix Scaffold"

1

Zheng, Le, Shuangshuang Zheng, Zilong Chen, et al. "Preparation and Properties of Decellularized Sheep Kidney Derived Matrix Scaffolds." Journal of Physics: Conference Series 2160, no. 1 (2022): 012014. http://dx.doi.org/10.1088/1742-6596/2160/1/012014.

Full text
Abstract:
Abstract Scaffolds from tissues or organs have nanoscale microstructures. Derived matrix scaffolds prepared by decellularized method can provide more cell attachment sites, which is conducive to cell adhesion, proliferation, differentiation and other physiological activities on scaffolds. In this study, the sheep kidney decellularized matrix scaffold was prepared by the method of decellularization. Due to the poor mechanical properties of the decellularized matrix, the cross linking method was adopted to enhance its mechanical properties. The decellularization efficiency of sheep renal matrix
APA, Harvard, Vancouver, ISO, and other styles
2

AA Ayu Asri Prima Dewi, Komang Trisna Sumadewi, Putu Diah Witari, Fransiscus Fiano Anthony Kerans, Luh Gde Evayanti, and Dewa Ayu Agung Alit Suka Astini. "Macroscopic and microscopic features of pancreatic scaffold generated by SDS-based decellularization using multiple needle injections." Intisari Sains Medis 14, no. 3 (2023): 1028–31. http://dx.doi.org/10.15562/ism.v14i3.1843.

Full text
Abstract:
Background: Pancreatic tissue engineering requires a scaffold in addition to cells and signaling. An adequate scaffold no longer contains cells but retains its extracellular matrix. Biological scaffolds from organ or tissue decellularization are widely used because they can retain the extracellular matrix essential for cell proliferation and differentiation. Pancreatic scaffolds were developed for pancreatic tissue engineering through various decellularization techniques. Available decellularization techniques have advantages and disadvantages, and the development of new techniques is necessar
APA, Harvard, Vancouver, ISO, and other styles
3

Rajagopal, Karthikeyan, Sowmya Ramesh, Noel Malcolm Walter, Aditya Arora, Dhirendra S. Katti, and Vrisha Madhuri. "In vivo cartilage regeneration in a multi-layered articular cartilage architecture mimicking scaffold." Bone & Joint Research 9, no. 9 (2020): 601–12. http://dx.doi.org/10.1302/2046-3758.99.bjr-2019-0210.r2.

Full text
Abstract:
Aims Extracellular matrix (ECM) and its architecture have a vital role in articular cartilage (AC) structure and function. We hypothesized that a multi-layered chitosan-gelatin (CG) scaffold that resembles ECM, as well as native collagen architecture of AC, will achieve superior chondrogenesis and AC regeneration. We also compared its in vitro and in vivo outcomes with randomly aligned CG scaffold. Methods Rabbit bone marrow mesenchymal stem cells (MSCs) were differentiated into the chondrogenic lineage on scaffolds. Quality of in vitro regenerated cartilage was assessed by cell viability, gro
APA, Harvard, Vancouver, ISO, and other styles
4

Kondiah, Pariksha Jolene, Pierre P. D. Kondiah, Yahya E. Choonara, Thashree Marimuthu, and Viness Pillay. "A 3D Bioprinted Pseudo-Bone Drug Delivery Scaffold for Bone Tissue Engineering." Pharmaceutics 12, no. 2 (2020): 166. http://dx.doi.org/10.3390/pharmaceutics12020166.

Full text
Abstract:
A 3D bioprinted pseudo-bone drug delivery scaffold was fabricated to display matrix strength, matrix resilience, as well as porous morphology of healthy human bone. Computer-aided design (CAD) software was employed for developing the 3D bioprinted scaffold. Further optimization of the scaffold was undertaken using MATLAB® software and artificial neural networks (ANN). Polymers employed for formulating the 3D scaffold comprised of polypropylene fumarate (PPF), free radical polymerized polyethylene glycol- polycaprolactone (PEG-PCL-PEG), and pluronic (PF127). Simvastatin was incorporated into th
APA, Harvard, Vancouver, ISO, and other styles
5

Roth, Susanne Pauline, Walter Brehm, Claudia Groß, Patrick Scheibe, Susanna Schubert, and Janina Burk. "Transforming Growth Factor Beta 3-Loaded Decellularized Equine Tendon Matrix for Orthopedic Tissue Engineering." International Journal of Molecular Sciences 20, no. 21 (2019): 5474. http://dx.doi.org/10.3390/ijms20215474.

Full text
Abstract:
Transforming growth factor beta 3 (TGFβ3) promotes tenogenic differentiation and may enhance tendon regeneration in vivo. This study aimed to apply TGFβ3 absorbed in decellularized equine superficial digital flexor tendon scaffolds, and to investigate the bioactivity of scaffold-associated TGFβ3 in an in vitro model. TGFβ3 could effectively be loaded onto tendon scaffolds so that at least 88% of the applied TGFβ3 were not detected in the rinsing fluid of the TGFβ3-loaded scaffolds. Equine adipose tissue-derived multipotent mesenchymal stromal cells (MSC) were then seeded on scaffolds loaded wi
APA, Harvard, Vancouver, ISO, and other styles
6

Lari, Alireza, Tao Sun, and Naznin Sultana. "PEDOT:PSS-Containing Nanohydroxyapatite/Chitosan Conductive Bionanocomposite Scaffold: Fabrication and Evaluation." Journal of Nanomaterials 2016 (2016): 1–12. http://dx.doi.org/10.1155/2016/9421203.

Full text
Abstract:
Conductive poly(3,4-ethylenedioxythiophene)-poly(4-styrene sulfonate) (PEDOT:PSS) was incorporated into nanohydroxyapatite/chitosan (nHA/CS) composite scaffolds through a freezing and lyophilization technique. The bionanocomposite conductive scaffold was then characterized using several techniques. A scanning electron microscope image showed that the nHA and PEDOT:PSS were dispersed homogeneously in the chitosan matrix, which was also confirmed by energy-dispersive X-ray (EDX) analysis. The conductive properties were measured using a digital multimeter. The weight loss and water-uptake propert
APA, Harvard, Vancouver, ISO, and other styles
7

Wang, Xue Jun, Tao Lou, Jing Yang, Zhen Yang та Kun Peng He. "Preparation of PLLA/HAP/β-TCP Composite Scaffold for Bone Tissue Engineering". Applied Mechanics and Materials 513-517 (лютий 2014): 143–46. http://dx.doi.org/10.4028/www.scientific.net/amm.513-517.143.

Full text
Abstract:
In this study, a nanofibrous poly (L-lactic acid) (PLLA) scaffold reinforced by Hydroxyapatite (HAP) and β-tricalcium phosphate (β-TCP) was fabricated using the thermally induced phase separation method. The composite scaffold morphology showed a nanofibrous PLLA matrix and evenly distributed β-TCP/HAP particles. The composite scaffold had interconnective micropores and the pore size ranged 2-10 μm. Introducing β-TCP/HAP particles into PLLA matrix significantly improved the mechanical properties of the composite scaffold. In summary, the new composite scaffolds show a great deal promise for us
APA, Harvard, Vancouver, ISO, and other styles
8

Wu, Yao Hong, Bao Shan Xu, Qiang Yang, et al. "Fabrication and Evaluation of a Novel Integrated Annulus Fibrosus-Nucleus Pulposus Hybrid Scaffold." Advanced Materials Research 647 (January 2013): 688–91. http://dx.doi.org/10.4028/www.scientific.net/amr.647.688.

Full text
Abstract:
The scope of this study was to fabricate and evaluate a novel integrated annulus fibrosus-nucleus pulposus scaffold composed of bone matrix gelatin (BMG) and cartilage extracellular matrix (ECM) respectively. Scaffolds were fabricated by a serial physicochemical and free-drying process. The physiochemical property and compatibility of the composite scaffold with intervertebral disc cells were evaluated. HE staining showed no residual cells in both annulus fibrosus and nucleus pulposus scaffolds. SEM observation revealed that the integration of annulus fibrosus region and nucleus pulposus regio
APA, Harvard, Vancouver, ISO, and other styles
9

Xiao, Tongguang, Weimin Guo, Mingxue Chen, et al. "Fabrication and In Vitro Study of Tissue-Engineered Cartilage Scaffold Derived from Wharton’s Jelly Extracellular Matrix." BioMed Research International 2017 (2017): 1–12. http://dx.doi.org/10.1155/2017/5839071.

Full text
Abstract:
The scaffold is a key element in cartilage tissue engineering. The components of Wharton’s jelly are similar to those of articular cartilage and it also contains some chondrogenic growth factors, such as insulin-like growth factor I and transforming growth factor-β. We fabricated a tissue-engineered cartilage scaffold derived from Wharton’s jelly extracellular matrix (WJECM) and compared it with a scaffold derived from articular cartilage ECM (ACECM) using freeze-drying. The results demonstrated that both WJECM and ACECM scaffolds possessed favorable pore sizes and porosities; moreover, they s
APA, Harvard, Vancouver, ISO, and other styles
10

Guimaraes, Alberto Bruning, Aristides Tadeu Correia, Ronaldo Soares da Silva, et al. "Evaluation of Structural Viability of Porcine Tracheal Scaffolds after 3 and 6 Months of Storage under Three Different Protocols." Bioengineering 10, no. 5 (2023): 584. http://dx.doi.org/10.3390/bioengineering10050584.

Full text
Abstract:
Tracheal replacement with a bioengineered tracheal substitute has been developed for long-segment tracheal diseases. The decellularized tracheal scaffold is an alternative for cell seeding. It is not defined if the storage scaffold produces changes in the scaffold’s biomechanical properties. We tested three protocols for porcine tracheal scaffold preservation immersed in PBS and alcohol 70%, in the fridge and under cryopreservation. Ninety-six porcine tracheas (12 in natura, 84 decellularized) were divided into three groups (PBS, alcohol, and cryopreservation). Twelve tracheas were analyzed af
APA, Harvard, Vancouver, ISO, and other styles
More sources

Dissertations / Theses on the topic "Matrix Scaffold"

1

Wong, Cho Yi. "Characterization of Fibrin Matrix Incorporated Electrospun Polycaprolactone Scaffold." VCU Scholars Compass, 2016. http://scholarscompass.vcu.edu/etd/4103.

Full text
Abstract:
Specific objective: Guided tissue regeneration (GTR) aims to regenerate the lost attachment apparatus caused by periodontal disease through the use of a barrier membrane. For the GTR procedures to be successful, barrier membranes are required to be present at the surgical site for an extended period of time (weeks to months). Synthetic membranes have the advantage of prolonged presence in a wound site; however, they do not actively contribute to wound healing. Biologic membranes are recognized by the host tissue and participate in wound healing but have the disadvantage of early resorption. Th
APA, Harvard, Vancouver, ISO, and other styles
2

Gishto, Arsela. "SCAFFOLD COMPOSITION AND ARCHITECTURE CRITICALLY REGULATE EXTRACELLULAR MATRIX SYNTHESIS BY CARDIOMYOCYTES." Cleveland State University / OhioLINK, 2013. http://rave.ohiolink.edu/etdc/view?acc_num=csu1386941945.

Full text
APA, Harvard, Vancouver, ISO, and other styles
3

Gordon, Timothy D. 1971. "Effects of biochemical and mechanical stimulation of articular chondrocytes in collagen-GAG scaffolds : extracellular matrix biosynthesis and scaffold stiffness." Thesis, Massachusetts Institute of Technology, 2004. http://hdl.handle.net/1721.1/30299.

Full text
Abstract:
Thesis (S.M.)--Massachusetts Institute of Technology, Dept. of Mechanical Engineering, 2004.<br>Includes bibliographical references (p. 55-59).<br>As the incidence of osteoarthritis and other degenerative joint conditions continues to grow, rehabilitation via tissue engineering is becomingly increasingly attractive as an alternative to traditional surgical interventions. Chapters 2 and 3 of this thesis are specifically concerned with cartilage tissue engineering, while chapter 4 is relevant to bone and osteochondral tissue engineering. The cartilage tissue engineering sections focus on the eff
APA, Harvard, Vancouver, ISO, and other styles
4

Grassl, Martina Gabriele. "Experimentelle Untersuchung zur Entwicklung einer optimierten bioresorbierbaren Polymer-Matrix für das Tissue-Engineering mittels einer neuartigen Scaffold in Scaffold-Technik /." Regensburg, 2008. http://opac.nebis.ch/cgi-bin/showAbstract.pl?sys=000253176.

Full text
APA, Harvard, Vancouver, ISO, and other styles
5

Schröder, Jörg. "Design and synthesis of matrix metalloproteinase inhibitors derived from a 6H-1,3,4-thiadiazine scaffold." [S.l.] : [s.n.], 2001. http://deposit.ddb.de/cgi-bin/dokserv?idn=963015079.

Full text
APA, Harvard, Vancouver, ISO, and other styles
6

Baer, Alexandra E. M. "Funktioneller Vergleich von S-MARs ('scaffold-matrix attachment regions') und Insulatoren im chromosomalen Kontext." [S.l.] : [s.n.], 2002. http://deposit.ddb.de/cgi-bin/dokserv?idn=965617777.

Full text
APA, Harvard, Vancouver, ISO, and other styles
7

Kitamura, Morimasa. "Glottic Regeneration with Tissue Engineering Technique Using Acellular Extracellular Matrix Scaffold in a Canine Model." Kyoto University, 2014. http://hdl.handle.net/2433/189639.

Full text
APA, Harvard, Vancouver, ISO, and other styles
8

Puchalska, Monika [Verfasser], and Gerhard [Akademischer Betreuer] Mittler. "Quantitative proteomic analysis of the interactome of mammalian S/MAR (scaffold/matrix attachment region) elements​." Freiburg : Universität, 2018. http://d-nb.info/1216826447/34.

Full text
APA, Harvard, Vancouver, ISO, and other styles
9

Marumoto, Ariane. "Complexo Quinômico envolvido com adaptação de osteoblasto em scaffold orgânico sob condição de diferenciação celular." Botucatu, 2016. http://hdl.handle.net/11449/143761.

Full text
Abstract:
Orientador: Willian Fernando Zambuzzi<br>Resumo: Modelos in vitro têm facilitado a análise da fisiologia celular sob condições experimentais diversas; trata-se de modelo alternativo ao uso de animais de experimentação, que vem sendo difundido e aceito amplamente em pesquisa científica. Além disso, estes modelos têm levado à avanços significativos na compreensão das interações mútuas e adaptativas entre células e substratos. Neste trabalho, nosso objetivo foi analisar eventos moleculares responsáveis pela adaptação de preosteoblastos em substrato orgânico composto por componentes da Matriz Extr
APA, Harvard, Vancouver, ISO, and other styles
10

Li, Zhaoying. "Adaptive fabrication of biofunctional decellularized extracellular matrix niche towards complex engineered tissues." Thesis, University of Cambridge, 2017. https://www.repository.cam.ac.uk/handle/1810/270349.

Full text
Abstract:
Recreating organ-specific microenvironments of the extracellular matrix (ECM) in vitro has been an ongoing challenge in biofabrication. In this study, I present a biofunctional ECM-mimicking protein scaffold with tunable biochemical, mechanical and topographical properties. This scaffold, formed by microfibres, displays three favorable characteristics as a cell culture platform: high-loading of key ECM proteins, single-layered mesh membrane with controllable mesh size, and flexibility for supporting a range of cell culture configurations. Decellularized extracellular matrix (dECM) powder was u
APA, Harvard, Vancouver, ISO, and other styles
More sources

Books on the topic "Matrix Scaffold"

1

1958-, Atala Anthony, and Mooney David J. 1964-, eds. Synthetic biodegradable polymer scaffolds. Birkhäuser, 1997.

Find full text
APA, Harvard, Vancouver, ISO, and other styles
2

Lennon, Rachel, and Neil Turner. The molecular basis of glomerular basement membrane disorders. Edited by Neil Turner. Oxford University Press, 2018. http://dx.doi.org/10.1093/med/9780199592548.003.0320_update_001.

Full text
Abstract:
The glomerular basement membrane (GBM) is a condensed network of extracellular matrix molecules which provides a scaffold and niche to support the function of the overlying glomerular cells. Within the glomerulus, the GBM separates the fenestrated endothelial cells, which line capillary walls from the epithelial cells or podocytes, which cover the outer aspect of the capillaries. In common with basement membranes throughout the body, the GBM contains core components including collagen IV, laminins, nidogens, and heparan sulphate proteoglycans. However, specific isoforms of these proteins are r
APA, Harvard, Vancouver, ISO, and other styles
3

Duncan, Anthony, and Michel Janssen. Constructing Quantum Mechanics. Oxford University Press, 2019. http://dx.doi.org/10.1093/oso/9780198845478.001.0001.

Full text
Abstract:
This is the first of two volumes on the genesis of quantum mechanics. It covers the key developments in the period 1900–1923 that provided the scaffold on which the arch of modern quantum mechanics was built in the period 1923–1927 (covered in the second volume). After tracing the early contributions by Planck, Einstein, and Bohr to the theories of black‐body radiation, specific heats, and spectroscopy, all showing the need for drastic changes to the physics of their day, the book tackles the efforts by Sommerfeld and others to provide a new theory, now known as the old quantum theory. After s
APA, Harvard, Vancouver, ISO, and other styles

Book chapters on the topic "Matrix Scaffold"

1

Chen, Guobao, and Yonggang Lv. "Decellularized Bone Matrix Scaffold for Bone Regeneration." In Methods in Molecular Biology. Springer New York, 2017. http://dx.doi.org/10.1007/7651_2017_50.

Full text
APA, Harvard, Vancouver, ISO, and other styles
2

Nikolic, Iva. "More than a Scaffold: Extracellular Matrix in Vascular Signaling." In Endothelial Signaling in Development and Disease. Springer New York, 2015. http://dx.doi.org/10.1007/978-1-4939-2907-8_7.

Full text
APA, Harvard, Vancouver, ISO, and other styles
3

Inman, Jamie L., Joni D. Mott, and Mina J. Bissell. "The Extracellular Matrix as a Multivalent Signaling Scaffold that Orchestrates Tissue Organization and Function." In Tumor-Associated Fibroblasts and their Matrix. Springer Netherlands, 2011. http://dx.doi.org/10.1007/978-94-007-0659-0_16.

Full text
APA, Harvard, Vancouver, ISO, and other styles
4

Nair, Reshma S., and T. V. Anilkumar. "Fabrication of a Conductive Scaffold from Porcine Cholecystic Extracellular Matrix." In Springer Protocols Handbooks. Springer US, 2022. http://dx.doi.org/10.1007/978-1-0716-2425-8_9.

Full text
APA, Harvard, Vancouver, ISO, and other styles
5

Monzavi, Seyed Mostafa, Abdol-Mohammad Kajbafzadeh, Shabnam Sabetkish, and Alexander Seifalian. "Extracellular Matrix Scaffold Using Decellularized Cartilage for Hyaline Cartilage Regeneration." In Advances in Experimental Medicine and Biology. Springer International Publishing, 2021. http://dx.doi.org/10.1007/978-3-030-82735-9_17.

Full text
APA, Harvard, Vancouver, ISO, and other styles
6

Gluch, A., M. Vidakovic, and J. Bode. "Scaffold/Matrix Attachment Regions (S/MARs): Relevance for Disease and Therapy." In Handbook of Experimental Pharmacology. Springer Berlin Heidelberg, 2008. http://dx.doi.org/10.1007/978-3-540-72843-6_4.

Full text
APA, Harvard, Vancouver, ISO, and other styles
7

Kim, Dongyeop, and Marlise I. Klein. "The Extracellular Matrix: A Scaffold for Microbial Community Assembly and Function." In Springer Series on Biofilms. Springer Nature Switzerland, 2025. https://doi.org/10.1007/978-3-031-82202-5_5.

Full text
APA, Harvard, Vancouver, ISO, and other styles
8

Cui, Lei, Dong Li, Xiang Dong Liu, Fanfan Chen, Wei Liu, and Yi Lin Cao. "Experimental Study of Partially Demineralized Bone Matrix as Bone Tissue Engineering Scaffold." In Advanced Biomaterials VI. Trans Tech Publications Ltd., 2005. http://dx.doi.org/10.4028/0-87849-967-9.63.

Full text
APA, Harvard, Vancouver, ISO, and other styles
9

Sabetkish, Shabnam, and Abdol-Mohammad Kajbafzadeh. "The Renal Extracellular Matrix as a Supportive Scaffold for Kidney Tissue Engineering: Progress and Future Considerations." In Advances in Experimental Medicine and Biology. Springer International Publishing, 2021. http://dx.doi.org/10.1007/978-3-030-82735-9_9.

Full text
APA, Harvard, Vancouver, ISO, and other styles
10

Engelhardt, Eva-Maria, A. Oberbek, D. Aibibu, et al. "Towards the Use of CHO Produced Recombinant Extracellular Matrix Proteins as Bioactive Elements in a 3-D Scaffold for Tissue Engineering." In Cells and Culture. Springer Netherlands, 2010. http://dx.doi.org/10.1007/978-90-481-3419-9_3.

Full text
APA, Harvard, Vancouver, ISO, and other styles

Conference papers on the topic "Matrix Scaffold"

1

Dishowitz, Michael I., Miltiadis H. Zgonis, Jeremy J. Harris, Constance Ace, and Louis J. Soslowsky. "Strength Retention of a New Microbial Cellulose Scaffold and Existing Collagen-Based Scaffolds After In Vivo Implantation in a Rabbit Model." In ASME 2009 Summer Bioengineering Conference. American Society of Mechanical Engineers, 2009. http://dx.doi.org/10.1115/sbc2009-203619.

Full text
Abstract:
Rotator cuff tendon tears often require large tensions for repair [1] and these tensions are associated with poor outcomes including rerupture [2]. To address this, repairs are often augmented with collagen-based scaffolds. Microbial cellulose, produced by A. xylinum as a laminar non-woven matrix, is another candidate for repair augmentation [3]. An ideal augmentation scaffold would shield the repair site from damaging loads as they change throughout the healing process. Although the initial mechanical properties of clinically used scaffolds have been well characterized [4–6], their mechanical
APA, Harvard, Vancouver, ISO, and other styles
2

Sebastine, I. M., and D. J. Williams. "Requirements for the Manufacturing of Scaffold Biomaterial With Features at Multiple Scales." In ASME 2005 International Mechanical Engineering Congress and Exposition. ASMEDC, 2005. http://dx.doi.org/10.1115/imece2005-82515.

Full text
Abstract:
Tissue engineering aims to restore the complex function of diseased tissue using cells and scaffold materials. Tissue engineering scaffolds are three-dimensional (3D) structures that assist in the tissue engineering process by providing a site for cells to attach, proliferate, differentiate and secrete an extra-cellular matrix, eventually leading cells to form a neo-tissue of predetermined, three-dimensional shape and size. For a scaffold to function effectively, it must possess the optimum structural parameters conducive to the cellular activities that lead to tissue formation; these include
APA, Harvard, Vancouver, ISO, and other styles
3

Gilbert, Thomas W., James H. C. Wang, Stephen F. Badylak, and Savio L. Y. Woo. "Development of a Novel Model System to Study Remodeling of ECM Scaffolds in Response to Cyclic Stretching." In ASME 2003 International Mechanical Engineering Congress and Exposition. ASMEDC, 2003. http://dx.doi.org/10.1115/imece2003-41444.

Full text
Abstract:
In an effort to better understand the role of mechanical loading on the healing and remodeling of biological tissues, a number of in vitro models have been developed to apply either static or cyclic mechanical load to cell-seeded scaffolds (Huang 1993, Langelier 1999, Cacou 2000). The current study describes the validation of a new system designed to facilitate the study of matrix remodeling in cell seeded scaffolds, as well as the formation of tissue engineered scaffolds for potential use in repair of healing ligaments and tendons. Our objective was to develop a system that would allow a cell
APA, Harvard, Vancouver, ISO, and other styles
4

Courtney, Todd D., Jun Liao, William R. Wagner, and Michael S. Sacks. "Local Non-Affine Deformations and Fiber Kinematics of Elastomeric Electrospun Scaffolds." In ASME 2007 Summer Bioengineering Conference. American Society of Mechanical Engineers, 2007. http://dx.doi.org/10.1115/sbc2007-176720.

Full text
Abstract:
For most tissue engineering applications that seek to generate tissue de novo, the scaffold is the first step in a series of important developmental considerations. Whether synthetic or natural, scaffolds developed for immediate in vivo use must have mechanical properties comparable to the native tissue for at least the minimum time necessary for the accompanying seeded cells, and eventual cells that migrate in, to lay down an equivalent supporting matrix. Scaffolds developed for the purpose of growing a tissue in vitro, with eventual in vivo use, need not necessarily meet these mechanical req
APA, Harvard, Vancouver, ISO, and other styles
5

Adhikari, Udhab, Nava P. Rijal, Shalil Khanal, Devdas Pai, Jagannathan Sankar, and Narayan Bhattarai. "Magnesium and Calcium-Containing Scaffolds for Bone Tissue Regeneration." In ASME 2016 International Mechanical Engineering Congress and Exposition. American Society of Mechanical Engineers, 2016. http://dx.doi.org/10.1115/imece2016-66835.

Full text
Abstract:
Bone is a living tissue that constantly remodels and adapts to the stresses imposed upon it. Bone disorders are of growing concern as the median age of our population rises. Healing and recovery from fractures requires bone cells to have a 3-dimensional (3D) structural base, or scaffold, to grow out from. In addition to providing mechanical support, the scaffold, an extracellular matrix (ECM) assembly, enables the transport of nutrients and oxygen in and removal of waste materials from cells that are growing into new tissue. In this research, a 3D scaffold was synthesized with chitosan (CS), c
APA, Harvard, Vancouver, ISO, and other styles
6

Kugler, Lindsay E., Kenneth W. Ng, Christopher J. O’Conor, Gerard A. Ateshian, and Clark T. Hung. "Scaffold Properties Play a Critical Role in the Retention of Synthesized Glycosaminoglycans in Tissue Engineered Cartilage." In ASME 2007 Summer Bioengineering Conference. American Society of Mechanical Engineers, 2007. http://dx.doi.org/10.1115/sbc2007-176558.

Full text
Abstract:
Agarose has been used as a model scaffold for cartilage tissue engineering research due to its maintenance of chondrocyte phenotype, support of cartilage tissue development, and ability to transmit mechanical stimuli [1–4]. In a previous study, the temporal application of TGF-β3 for only 2 weeks resulted in explosive growth in the functional properties of tissue engineered cartilage [5]. The role of scaffolds in tissue engineering includes providing a physiologic three-dimensional environment for cells, decreased path lengths for diffusion and retention of cell elaborated matrix. In past studi
APA, Harvard, Vancouver, ISO, and other styles
7

Argento, G., M. Simonet, C. W. J. Oomens, and F. P. T. Baaijens. "Mechanics of Electrospun Scaffolds: An Application to Heart Valve Tissue Engineering." In ASME 2012 Summer Bioengineering Conference. American Society of Mechanical Engineers, 2012. http://dx.doi.org/10.1115/sbc2012-80724.

Full text
Abstract:
In the last decade electrospinning has shown its potential of being a feasible technique to manufacture scaffolds for tissue engineering [1]. Previous studies observed that, on a micrometer scale, the topology of the scaffold plays a fundamental role in the spreading and the differentiation of the cells [2], and in the growth of neo-extracellular matrix. On a tissue scale (in the order of cm) the stiffness of the construct enables the possibility of applying mechanical cues for the development of a functional engineered tissue [3]. Studies on scaffold mechanics based on volume-averaging theory
APA, Harvard, Vancouver, ISO, and other styles
8

Liao, Jun, W. David Merryman, Yi Hong, et al. "Cellular Deformations in Microintegrated Electrospun Poly (Ester Urethane) Urea Scaffolds Under Biaxial Stretch." In ASME 2007 Summer Bioengineering Conference. American Society of Mechanical Engineers, 2007. http://dx.doi.org/10.1115/sbc2007-176726.

Full text
Abstract:
Recently, vascular smooth muscle cells (SMCs) have been electrosprayed concurrently with electrospun biodegradable elastomeric poly (ester urethane) urea (PEUU) to form cell-microintegrated scaffolds [1]. These scaffolds exhibit soft tissue-like elastomeric mechanical properties [2], and are thus promising candidates for repair or replacement of diseased cardiovascular tissues. The level of cellular deformation during in vitro mechanical training will likely influence the extracellular matrix formation. However, these deformations are likely complex and dependent upon both scaffold properties
APA, Harvard, Vancouver, ISO, and other styles
9

Allee, Tyler J., and Wan-Ju Li. "Novel Biomimetic Scaffold for Tendon/Ligament Tissue Engineering." In ASME 2010 First Global Congress on NanoEngineering for Medicine and Biology. ASMEDC, 2010. http://dx.doi.org/10.1115/nemb2010-13337.

Full text
Abstract:
An emerging approach to repair and replace a great number of the ligament and tendon injuries that occur each year is the use of tissue engineering principles to fabricate replacement tissues. One of the current challenges in tendon/ligament tissue engineering is fabricating scaffolds that possess both the proper mechanical and biological properties. A promising strategy to produce such scaffolds is electrospinning. Electrospinning uses a high-voltage power supply to draw viscous polymer solutions into ultra-fine fibers with nanometer-scale diameters, thus structurally mimicking native extrace
APA, Harvard, Vancouver, ISO, and other styles
10

Jabbari, Esmaiel, David N. Rocheleau, Weijie Xu, and Xuezhong He. "Fabrication of Biomimetic Scaffolds With Well-Defined Pore Geometry by Fused Deposition Modeling." In ASME 2007 International Manufacturing Science and Engineering Conference. ASMEDC, 2007. http://dx.doi.org/10.1115/msec2007-31011.

Full text
Abstract:
It is well established that the pore size and distribution affect the rate of cell migration and the extent of extracellular matrix formation. The objective of this work was to develop a process for fabrication of biodegradable and shape-specific polymeric scaffolds with well-defined pore geometry, functionalized with covalently attached bioactive peptides, for applications in tissue regeneration. We have used the Fused Deposition Modeling (FDM) RP technology to fabricate degradable and functional scaffolds with well-defined pore geometry. Computer aided design (CAD) using SolidWorks was used
APA, Harvard, Vancouver, ISO, and other styles
We offer discounts on all premium plans for authors whose works are included in thematic literature selections. Contact us to get a unique promo code!