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Dissertations / Theses on the topic 'Matrix Scaffold'

Author: Grafiati
Published: 3 June 2025
Last updated: 31 July 2025

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1

Wong, Cho Yi. "Characterization of Fibrin Matrix Incorporated Electrospun Polycaprolactone Scaffold." VCU Scholars Compass, 2016. http://scholarscompass.vcu.edu/etd/4103.

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Specific objective: Guided tissue regeneration (GTR) aims to regenerate the lost attachment apparatus caused by periodontal disease through the use of a barrier membrane. For the GTR procedures to be successful, barrier membranes are required to be present at the surgical site for an extended period of time (weeks to months). Synthetic membranes have the advantage of prolonged presence in a wound site; however, they do not actively contribute to wound healing. Biologic membranes are recognized by the host tissue and participate in wound healing but have the disadvantage of early resorption. Th
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2

Gishto, Arsela. "SCAFFOLD COMPOSITION AND ARCHITECTURE CRITICALLY REGULATE EXTRACELLULAR MATRIX SYNTHESIS BY CARDIOMYOCYTES." Cleveland State University / OhioLINK, 2013. http://rave.ohiolink.edu/etdc/view?acc_num=csu1386941945.

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3

Gordon, Timothy D. 1971. "Effects of biochemical and mechanical stimulation of articular chondrocytes in collagen-GAG scaffolds : extracellular matrix biosynthesis and scaffold stiffness." Thesis, Massachusetts Institute of Technology, 2004. http://hdl.handle.net/1721.1/30299.

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Thesis (S.M.)--Massachusetts Institute of Technology, Dept. of Mechanical Engineering, 2004.<br>Includes bibliographical references (p. 55-59).<br>As the incidence of osteoarthritis and other degenerative joint conditions continues to grow, rehabilitation via tissue engineering is becomingly increasingly attractive as an alternative to traditional surgical interventions. Chapters 2 and 3 of this thesis are specifically concerned with cartilage tissue engineering, while chapter 4 is relevant to bone and osteochondral tissue engineering. The cartilage tissue engineering sections focus on the eff
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4

Grassl, Martina Gabriele. "Experimentelle Untersuchung zur Entwicklung einer optimierten bioresorbierbaren Polymer-Matrix für das Tissue-Engineering mittels einer neuartigen Scaffold in Scaffold-Technik /." Regensburg, 2008. http://opac.nebis.ch/cgi-bin/showAbstract.pl?sys=000253176.

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5

Schröder, Jörg. "Design and synthesis of matrix metalloproteinase inhibitors derived from a 6H-1,3,4-thiadiazine scaffold." [S.l.] : [s.n.], 2001. http://deposit.ddb.de/cgi-bin/dokserv?idn=963015079.

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6

Baer, Alexandra E. M. "Funktioneller Vergleich von S-MARs ('scaffold-matrix attachment regions') und Insulatoren im chromosomalen Kontext." [S.l.] : [s.n.], 2002. http://deposit.ddb.de/cgi-bin/dokserv?idn=965617777.

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7

Kitamura, Morimasa. "Glottic Regeneration with Tissue Engineering Technique Using Acellular Extracellular Matrix Scaffold in a Canine Model." Kyoto University, 2014. http://hdl.handle.net/2433/189639.

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8

Puchalska, Monika [Verfasser], and Gerhard [Akademischer Betreuer] Mittler. "Quantitative proteomic analysis of the interactome of mammalian S/MAR (scaffold/matrix attachment region) elements​." Freiburg : Universität, 2018. http://d-nb.info/1216826447/34.

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9

Marumoto, Ariane. "Complexo Quinômico envolvido com adaptação de osteoblasto em scaffold orgânico sob condição de diferenciação celular." Botucatu, 2016. http://hdl.handle.net/11449/143761.

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Orientador: Willian Fernando Zambuzzi<br>Resumo: Modelos in vitro têm facilitado a análise da fisiologia celular sob condições experimentais diversas; trata-se de modelo alternativo ao uso de animais de experimentação, que vem sendo difundido e aceito amplamente em pesquisa científica. Além disso, estes modelos têm levado à avanços significativos na compreensão das interações mútuas e adaptativas entre células e substratos. Neste trabalho, nosso objetivo foi analisar eventos moleculares responsáveis pela adaptação de preosteoblastos em substrato orgânico composto por componentes da Matriz Extr
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10

Li, Zhaoying. "Adaptive fabrication of biofunctional decellularized extracellular matrix niche towards complex engineered tissues." Thesis, University of Cambridge, 2017. https://www.repository.cam.ac.uk/handle/1810/270349.

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Recreating organ-specific microenvironments of the extracellular matrix (ECM) in vitro has been an ongoing challenge in biofabrication. In this study, I present a biofunctional ECM-mimicking protein scaffold with tunable biochemical, mechanical and topographical properties. This scaffold, formed by microfibres, displays three favorable characteristics as a cell culture platform: high-loading of key ECM proteins, single-layered mesh membrane with controllable mesh size, and flexibility for supporting a range of cell culture configurations. Decellularized extracellular matrix (dECM) powder was u
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11

Matskova, Liudmila V. "EBV membrane protein LMP2A interactions with ubiquitin ligases and signaling scaffold /." Stockholm, 2004. http://diss.kib.ki.se/2004/91-7140-068-0/.

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12

Reisbig, Nathalie A. "Synovial Extracellular Matrix and Synovial Mesenchymal Stem Cells are Chondrogenic In Vitro and In Vivo." The Ohio State University, 2018. http://rave.ohiolink.edu/etdc/view?acc_num=osu1543150403002824.

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13

Harley, Brendan A. (Brendan Andrew) 1978. "Cell-matrix interactions : collagen-GAG scaffold fabrication, characterization, and measurement of cell migratory and contractile behavior via confocal microscopy." Thesis, Massachusetts Institute of Technology, 2006. http://hdl.handle.net/1721.1/35678.

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Thesis (Sc. D.)--Massachusetts Institute of Technology, Dept. of Mechanical Engineering, 2006.<br>Includes bibliographical references (v. 2, leaves 371-393).<br>Three-dimensional, collagen scaffolds are an analog of the extracellular matrix and are used for many tissue engineering applications. While material and microstructural properties significantly affect overall scaffold bioactivity, the specific influence of construct mechanical properties, composition, and pore microstructure is unknown. In this thesis, experimental and theoretical approaches are employed to systematically examine the
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14

Aya, Rino. "Regeneration of elastic fibers by three-dimensional culture on a collagen scaffold and the addition of latent TGF-β binding protein 4 to improve elastic matrix deposition". Kyoto University, 2016. http://hdl.handle.net/2433/215396.

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15

Sell, Scott Allen. "Scaffold Permeability as a Means to Determine Fiber Diameter and Pore Size of Electrospun Fibrinogen." VCU Scholars Compass, 2006. http://scholarscompass.vcu.edu/etd/1311.

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The purpose of this study was to construct a flowmeter that could accurately measure the hydraulic permeability of electrospun fibrinogen scaffolds, providing insight into the transport properties of electrospun scaffolds while making the measurement of their topographical features (fiber and pore size) more accurate. Three different concentrations of fibrinogen were used (100, 120, and 150mg/ml) to create scaffolds with three different fiber diameters and pore sizes. The fiber diameters and pore sizes of the electrospun scaffolds were analyzed through scanning electron microscopy and image
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16

Ishikawa, Masaaki. "Transplantation of neurons derived from human iPS cells cultured on collagen matrix into guinea-pig cochleae." 京都大学 (Kyoto University), 2017. http://hdl.handle.net/2433/225472.

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17

Sofrenovic, Tanja. "Evaluation of an Enhanced (Sialyl Lewis-X) Collagen Matrix for Neovascularization and Myogenesis in a Mouse Model of Myocardial Infarction." Thesis, Université d'Ottawa / University of Ottawa, 2012. http://hdl.handle.net/10393/22747.

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In cardiovascular disease the repair response is insufficient to restore blood flow, leading to the death of muscle and loss of tissue function. Therefore, strategies to augment the endogenous cell response and its effects may help improve tissue recovery and function. In this study we explored the use of tissue-engineered collagen matrices for augmenting endogenous regenerative processes after myocardial infarction. Treatment with the sLeX-collagen matrix reduced inflammation and apoptosis and had a positive regenerative effect on the infarcted mouse heart, through improved vascular density a
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18

STOCCO, CHIARA. "Nanofiber polymeric scaffold for slow and steady release of VEGF and ECs to induce efficient angiogenesis and healing in a mouse model of hind limb ischemia." Doctoral thesis, Università degli Studi di Trieste, 2022. http://hdl.handle.net/11368/3015203.

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The primary aim of the project is the application of a biocompatible polymeric nanofiber scaffold, and the comparison with micrometric biological scaffold, both combined with endothelial cells (ECs) and vascular endothelial growth factor (VEGF) in a hindlimb ischemia mouse model in order to stimulate the angiogenis and muscle protection. Firstly, the hindlimb ischemic model (HLIM) was started to be developed, surgically ligating and transecting the left femoral artery of BALB/C mice, under operating microscope. Postoperative clinical assessment was performed according to the Tarlov score and t
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19

Guo, Xiaolei. "Engineering electrospun scaffolds to treat myocardial infarction." The Ohio State University, 2012. http://rave.ohiolink.edu/etdc/view?acc_num=osu1343072089.

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20

Alvarez, Fallas Mario Enrique. "Diaphragm derived acellular matrix as multistep study: from development to characterization using in vitro and in vivo strategies." Doctoral thesis, Università degli studi di Padova, 2016. http://hdl.handle.net/11577/3424392.

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Abstract Introduction The demand for organ transplantation has rapidly increased during the past decades, thus requiring the development of a new interdisciplinary field, aimed at supplying this demand. Branching from regenerative medicine, the combination of elements usually applied separately for same or other purposes, was named Tissue Engineering (TE). Precisely, the components combined in TE constitute the so-called TE triad, are i) cells (derived from cell therapy), ii) scaffolding material (derived from material science) and iii) molecular signals (mainly derived from molecular bi
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21

Jordan, Alex Michael. "FIBER-COMPOSITE IN SITU FABRICATION: MULTILAYER COEXTRUSION AS AN ENABLING TECHNOLOGY." Case Western Reserve University School of Graduate Studies / OhioLINK, 2016. http://rave.ohiolink.edu/etdc/view?acc_num=case1467832877.

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22

D'Angelo, Edoardo. "Decellularized colorectal cancer matrix as bioactive microenvironment for in vitro 3D cancer research." Doctoral thesis, Università degli studi di Padova, 2018. http://hdl.handle.net/11577/3426811.

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Three-dimensional (3D) cancer models are overlooking the scientific landscape with the primary goal of bridging the gaps between two-dimensional (2D) cell cultures, animal models and clinical research. In this thesis, we describe an innovative tissue engineering approach applied to colorectal cancer (CRC) starting from decellularized human biopsies in order to generate an organotypic 3D bioactive model. This in vitro 3D system recapitulates the ultrastructural environment of native tissue as demonstrated by histology, immunohistochemistry, immunofluorescence and scanning electron microscopy an
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23

Schanz, Johanna E. "Etablierung einer biologischen vaskularisierten Matrix als Grundlage für ein in vitro Lebertestsystem Establishment of a biological vascularized scaffold as a basis for in vitro liver test system /." [S.l. : s.n.], 2007. http://nbn-resolving.de/urn:nbn:de:bsz:93-opus-34146.

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24

Veyssiere, Alexis. "De la décellularisation de cartilage de porc à la chondrogenèse auriculaire." Thesis, Normandie, 2020. http://www.theses.fr/2020NORMC408.

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Les reconstructions auriculaires représentent un réel défi pour le chirurgien. Plusieurs techniques existent présentant chacune des inconvénients non négligeables.L’essor de l’ingénierie tissulaire des 20 dernières années ouvre la possibilité à de nouvelles thérapeutiques.L’ingénierie du cartilage ne déroge pas à la règle et connaît une sérieuse évolution, concernant le cartilage articulaire mais également les autres types de cartilages dont le cartilage auriculaire.Appliquées à la reconstruction auriculaire, ces techniques apportent du tissu cartilagineux tout en minorant les effets secondair
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25

Kolpa, Heather J. "XIST and CoT-1 Repeat RNAs are Integral Components of a Complex Nuclear Scaffold Required to Maintain SAF-A and Modify Chromosome Architecture: A Dissertation." eScholarship@UMMS, 2016. https://escholarship.umassmed.edu/gsbs_diss/825.

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XIST RNA established the precedent for a noncoding RNA that stably associates with and regulates chromatin, however it remains poorly understood how such RNAs structurally associate with the interphase chromosome territory. I demonstrate that transgenic XIST RNA localizes in cis to an autosome as it does to the inactive X chromosome, hence the RNA recognizes a structure common to all chromosomes. I reassess the prevalent thinking in the field that a single protein, Scaffold Attachment Factor-A (SAF-A/hnRNP U), provides a single molecule bridge required to directly tether the RNA to DNA. In an
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Kolpa, Heather J. "XIST and CoT-1 Repeat RNAs are Integral Components of a Complex Nuclear Scaffold Required to Maintain SAF-A and Modify Chromosome Architecture: A Dissertation." eScholarship@UMMS, 2004. http://escholarship.umassmed.edu/gsbs_diss/825.

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XIST RNA established the precedent for a noncoding RNA that stably associates with and regulates chromatin, however it remains poorly understood how such RNAs structurally associate with the interphase chromosome territory. I demonstrate that transgenic XIST RNA localizes in cis to an autosome as it does to the inactive X chromosome, hence the RNA recognizes a structure common to all chromosomes. I reassess the prevalent thinking in the field that a single protein, Scaffold Attachment Factor-A (SAF-A/hnRNP U), provides a single molecule bridge required to directly tether the RNA to DNA. In an
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27

Hammad, Mira. "Reconstruction of auricular cartilage using natural-derived scaffolds with an in vivo application in rabbit model Effects of hypoxia on chondrogenic differentiation of progenitor cells from different origins Cell sheets as tools for ear cartilage reconstruction in vivo Cartilage tissue engineering using apple cellulosic scaffolds Cell-secreted matrices as cell supports: Novel approaches for cell culture applications." Thesis, Normandie, 2021. http://www.theses.fr/2021NORMC404.

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La reconstruction des défauts du cartilage auriculaire nécessite une restauration appropriée par des sources cellulaires adéquates ainsi que la fourniture de supports appropriés pour les tissus. Ce travail visait à étudier différents échafaudages et biomatériaux pour l'ingénierie in vitro du cartilage auriculaire ainsi que la réparation in vivo du cartilage auriculaire chez des modèles de lapin. Nous avons d'abord montré que les périchondrocytes auriculaires sont les meilleurs candidats pour la régénération du cartilage auriculaire et que l'hypoxie n'est pas nécessaire à leur différenciation c
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28

Ghanavi, Parisa. "Effects of cartilage dust on cartilage formation in in vitro and in ectopic in vivo models." Thesis, Queensland University of Technology, 2016. https://eprints.qut.edu.au/101499/1/Parisa_Ghanavi_Thesis.pdf.

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This thesis is a comparative study of cartilage tissue regeneration by the tissue’s resident cells with or without adding the tissue matrix’s particles, in the lab and followed by implantation in mouse. Incorporation of the particles with the cells appears to be a viable strategy to increase the cartilage-like matrix content in the short-term, and the particles appear to integrate into the regenerated tissue in the long-term.
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29

Reisbig, Nathalie Ann. "Decellularization to Produce Biological Synovial Extracellular Matrix Scaffolds." The Ohio State University, 2016. http://rave.ohiolink.edu/etdc/view?acc_num=osu1461136148.

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30

Burrows, Mariana Carvalho. "Evaluation of electrospun PLLA-ECM scaffolds as biomaterials for bone regeneration." Universidade de São Paulo, 2016. http://www.teses.usp.br/teses/disponiveis/46/46136/tde-14092016-090552/.

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The extracellular matrix (ECM) is secreted by the host tissue and is an important key for mechanisms of cell responses. The main properties of the ECM materials include biodegradability, biocompatibility, and nanostructured in a 3D fibre network. In addition, ECM is composed of important molecules like growth factors, glycosaminoglycans (GAGs), collagens, fibronectin, and lamin, while final composition depends on the native tissue. We have selected for this study ECMs from cortical bone (B-ECM) and pericardium (P-ECM) tissue. These ECMs were digested by collagenase, pepsin and trypsin. Each of
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31

Reichert, Verena Maria Charlotte. "Application of a human bone engineering platform to an in vitro and in vivo breast cancer metastasis model." Thesis, Queensland University of Technology, 2011. https://eprints.qut.edu.au/53212/1/Verena_Reichert_Thesis.pdf.

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Breast cancer in its advanced stage has a high predilection to the skeleton. Currently, treatment options of breast cancer-related bone metastasis are restricted to only palliative therapeutic modalities. This is due to the fact that mechanisms regarding the breast cancer celI-bone colonisation as well as the interactions of breast cancer cells with the bone microenvironment are not fully understood, yet. This might be explained through a lack of appropriate in vitro and in vivo models that are currently addressing the above mentioned issue. Hence the hypothesis that the translation of a bo
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32

Shendi, Dalia M. "Cell-Derived Extracellular Matrix Scaffolds Developed using Macromolecular Crowding." Digital WPI, 2019. https://digitalcommons.wpi.edu/etd-dissertations/590.

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Cell-derived (CDM) matrix scaffolds provide a 3-dimensional (3D) matrix material that recapitulates a native, human extracellular matrix (ECM) microenvironment. CDMs are a heterogeneous source of ECM proteins with a composition dependent on the cell source and its phenotype. CDMs have several applications, such as for development of cell culture substrates to study stromal cell propagation and differentiation, as well as cell or drug delivery vehicles, or for regenerative biomaterial applications. Although CDMs are versatile and exhibit advantageous structure and activity, their use has been h
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33

Rosa, Vinicius. "Engenharia de tecidos com células-tronco de dentes decíduos e scaffolds injetáveis e a formação de polpa dental funcional." Universidade de São Paulo, 2010. http://www.teses.usp.br/teses/disponiveis/23/23140/tde-18082010-125759/.

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A translação da regeneração pulpar com células tronco para a clinica requerirá o uso de scaffolds injetáveis. O objetivo foi estudar o comportamento de células tronco obtidas de dentes decíduos exfoliados (SHED) injetados em canais radiculares de pré-molares humanos com ápice aberto com scaffold de colágeno recombinante humano tipo I (rhC-I) e a base de nanofibras auto-organizáveis (SA). Para determinar a viabilidade e potencial de diferenciação de SHED in vitro, raízes nao instrumentadas foram posicionadas com o ápice em meio de cultura. SHED ressuspendida em rhC e SA foram injetadas nos cana
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34

Dávila, Sánchez José Luis 1986. "Fabricação de scaffolds de PCL reforçados com ß-TCP mediante impressão 3D por rosca de extrusão para aplicações em engenharia tecidual." [s.n.], 2014. http://repositorio.unicamp.br/jspui/handle/REPOSIP/265863.

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Orientador: Marcos Akira D'Ávila<br>Dissertação (mestrado) - Universidade Estadual de Campinas, Faculdade de Engenharia Mecânica<br>Made available in DSpace on 2018-08-26T13:08:26Z (GMT). No. of bitstreams: 1 DavilaSanchez_JoseLuis_M.pdf: 7833063 bytes, checksum: 1e3a93b9b918ec86f9810207586b8fad (MD5) Previous issue date: 2014<br>Resumo: A engenharia tecidual é uma linha de pesquisa que emerge como a sinergia entre diferentes ramos da ciência. É orientada à obtenção de estruturas com características semelhantes à matriz extracelular (ECM) de diferentes órgãos e tecidos, com o objetivo de rep
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Ndreu, Albana. "Electrospun Nanofibrous Scaffolds For Tissue Engineering." Master's thesis, METU, 2007. http://etd.lib.metu.edu.tr/upload/12608226/index.pdf.

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In this study a microbial polyester, poly(3-hydroxybutyrate-co-3- hydroxyvalerate) (PHBV), and its blends were wet or electrospun into fibrous scaffolds for tissue engineering. Wet spun fiber diameters were in the low micrometer range (10-50 &amp<br>#956<br>m). The polymer concentration and the stirring rate affected the properties the most. The optimum concentration was determined as 15% (w/v). Electrospun fiber diameters, however, were thinner. Solution viscosity, potential, distance between the syringe tip and the collector, and polymer type affected the morphology and the thickness of bead
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Blaudez-Prat, Fanny. "Harnessing the native extracellular matrix to achieve periodontal regeneration." Thesis, Griffith University, 2021. http://hdl.handle.net/10072/405629.

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Periodontitis is a highly prevalent chronic inflammatory disease affecting more than 60% of the population, which leads to destruction of the tooth-supporting tissues. The periodontium is composed of both hard (bone and cementum) and soft tissues (periodontal ligament and gingiva), requiring a tissue-engineering approach to allow a precisely coordinated and compartmentalised healing response for subsequent structural and functional regeneration. The present study investigated the functionalisation of highly porous scaffolds with decellularised cell-laid extracellular matrix for periodontal reg
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Kumar, Vivek Ashok. "Design and evaluation of scaffolds for arterial grafts using extracellular matrix based materials." Diss., Georgia Institute of Technology, 2011. http://hdl.handle.net/1853/45869.

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For small diameter (<6 mm) blood vessel replacements, lack of collaterals and vascular disease preclude homografts; while synthetic analogs, ePTFE, expanded polytetrafluoroethylene, and PET, polyethyleneterephathalate, are prone to acute thrombosis and restenosis. It is postulated that the hierarchical assembly of cell populated matrices fabricated from protein analogs provides a new design strategy for generating a structurally viable tissue engineered vascular graft. To this end, synthetic elastin and collagen fiber analogs offer a novel strategy for creating tissue engineered vascular graft
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38

Cano, Torres Irene. "Cell derived-extracellular matrix scaffolds with polylactic acid microcarriers for tissue engineering and cell therapy." Doctoral thesis, Universitat Politècnica de Catalunya, 2019. http://hdl.handle.net/10803/666694.

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Organ shortage for transplantation and the need for new therapies for the treatment of tissular damages have driven the development of an exciting field in research, called tissue engineering (TE). Its potential entails future strategies that will allow the development of functional substitutes for damaged tissues, obtained in vitro under riskfree environments, using autologous cells that will integrate within the host aiding in the regeneration and restore of the lost function. However, still current efforts have to deal with several restraints in order to achieve that paradigm. The ai
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Tocchio, A. "DESIGN OF VASCULARIZABLE SCAFFOLDS FOR LARGE TISSUE ENGINEERING." Doctoral thesis, Università degli Studi di Milano, 2014. http://hdl.handle.net/2434/234142.

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The emerging field of tissue engineering is dedicated to restore, maintain or improve the functions of damaged or lost human tissues. However, despite significant successes have been achieved over the last 20 years, several challenges still remain, preventing a pervasive clinical application of tissue engineering. One of the main challenges lies in the development of scaffolding materials able to mimic the complex organization of the in vivo milieu and provide tailored stimuli for tissue growth and maturation. A fundamental aspect of this problem resides in the design of scaffolds having three
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40

Lovecchio, Joseph. "Monitoring the extracellular matrix mineralization processes in biological scaffolds using bioreactors, x-ray μct technology and 3-d modeling methods (monitoraggio dei processi di mineralizzazione della matrice extracellulare in scaffolds biologici, utilizzando bioreattore, tecnologia μct a raggi x e metodi di modellizzazione 3d)". Master's thesis, Alma Mater Studiorum - Università di Bologna, 2014. http://amslaurea.unibo.it/7016/.

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Al fine di migliorare le tecniche di coltura cellulare in vitro, sistemi a bioreattore sono sempre maggiormente utilizzati, e.g. ingegnerizzazione del tessuto osseo. Spinner Flasks, bioreattori rotanti e sistemi a perfusione di flusso sono oggi utilizzati e ogni sistema ha vantaggi e svantaggi. Questo lavoro descrive lo sviluppo di un semplice bioreattore a perfusione ed i risultati della metodologia di valutazione impiegata, basata su analisi μCT a raggi-X e tecniche di modellizzazione 3D. Un semplice bioreattore con generatore di flusso ad elica è stato progettato e costruito con l'obietti
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41

Knapp, Danielle Careen. "The Extraction of Type II Collagen and the Electrospinning of Nano-Fibrous Scaffolds." VCU Scholars Compass, 2005. http://scholarscompass.vcu.edu/etd/928.

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Articular cartilage lining joints, such as in the knee, functions to reduce friction and absorb shock. Collagen type II is the largest constituent in the extracellular matrix of articular cartilage and its restoration is of the highest interest to tissue engineers. Cartilage has little ability to naturally regenerate due to the absence of vascularity and the inability of the chondrocytes to proliferate at a high rate. It would be ideal to create a mimicking extracellular matrix/scaffold from type II collagen that could possibly be used to replace damaged articular cartilage that has the same f
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42

Kubow, Kristopher Edward. "How cell-derived 3D scaffolds direct the conformation of new fibronectin matrix assembled by reseeded cells /." Zürich : ETH, 2008. http://e-collection.ethbib.ethz.ch/show?type=diss&nr=18125.

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43

Wang, Hua. "Control of protein-surface, protein-protein, and cell-matrix interactions for biomaterials as tissue engineering scaffolds /." Thesis, Connect to this title online; UW restricted, 2005. http://hdl.handle.net/1773/9894.

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44

Koegler, Wendy S. 1971. "Fabrication of tissue engineering scaffolds with spatial control over architecture and cell-matrix interactions in 3D." Thesis, Massachusetts Institute of Technology, 2000. http://hdl.handle.net/1721.1/8997.

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Thesis (Ph.D.)--Massachusetts Institute of Technology, Dept. of Chemical Engineering, 2000.<br>Includes bibliographical references (leaves 131-141).<br>The key accomplishment of this work is the demonstration of spatial control over architecture and surface chemistry in three-dimensional tissue engineering scaffolds. Tissues are characterized by a well-defined three-dimensional arrangement of cells. Spatial control of scaffold elements may be used to encourage the organization of cells into conformations resembling those of native tissue. Patterned scaffolds can be used to explore the healing
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45

Hoyt, Laurie Christine. "Fibroblast Migration Mediated by the Composition of Tissue Engineered Scaffolds." VCU Scholars Compass, 2007. http://scholarscompass.vcu.edu/etd_retro/164.

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Tissue engineered scaffolds were constructed to mimic the native extracellular matrix (ECM) and promote cell migration of keratinocytes and fibroblasts. Electrospinning technology was used to fabricate these nano-scale matrices that consist of varying compositions and fiber diameters. The purpose of this study was to examine how average fiber diameter and scaffold composition regulate cell migration. Odyssey infrared scanning evaluated this on a macroscopic level, whereas confocal microscopy focused on a more microscopic approach. The expression of proteases released into the culture med
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46

Milan, Anna. "L'ingegneria tissutale e l'uso delle matrici decellularizzate nella terapia sostitutiva." Doctoral thesis, Università degli studi di Padova, 2016. http://hdl.handle.net/11577/3424477.

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ABSTRACT BACKGROUND: Oesophageal Atresia (OA) is a congenital defect that occurs during gestation and prevents the correct oesophagus development in 1 every 3000-4500 ¬births. Tissue Engineering could represent a therapeutic alternative for the most severe cases, where oesophageal replacement becomes necessary. Decellularised matrices are the ideal option because they are derived from tissue-specific extracellular-matrix (ECM) after removing all the cells therefore avoiding the risk of incompatibility and rejection. However, appropriate preservation may significantly affect scaffold behaviour
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47

Genové, Corominas Elsa. "Self-assembling peptide scaffolds as extracellular matrix analogs and their application in tissue engineering and regenerative biology." Doctoral thesis, Universitat Ramon Llull, 2007. http://hdl.handle.net/10803/9308.

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En aquesta Tesi, un nou biomaterial de disseny composat per seqüències peptídiques repetitives i amfifíliques, que per autoensamblatge forma xarxes de nanofibres (i hidrogels), AcN-RADARADARADARADA-CONH2, s´ha utilitzat com a anàleg de la matriu extracel·lular per al manteniment, proliferació i diferenciació cel·lular. Aquest pèptid s'ha funcionalititzat amb motius biològicament actius procedents de proteïnes de la matriu extracel·lular incloent laminina-1 i colàgen IV. El scaffold peptídic autoensamblant RAD16-I i els seus derivats biològicament actius s´han caracteritzat i provat utilitzant
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48

Zeng, Like. "SELF-ASSEMBLY OF SILK-ELASTINLIKE PROTEIN POLYMERS INTO THREE-DIMENSIONAL SCAFFOLDS FOR BIOMEDICAL APPLICATIONS." Diss., The University of Arizona, 2014. http://hdl.handle.net/10150/325002.

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Production of brand new protein-based materials with precise control over the amino acid sequences at single residue level has been made possible by genetic engineering, through which artificial genes can be developed that encode protein-based materials with desired features. As an example, silk-elastinlike protein polymers (SELPs), composed of tandem repeats of amino acid sequence motifs from Bombyx mori (silkworm) silk and mammalian elastin, have been produced in this approach. SELPs have been studied extensively in the past two decades, however, the fundamental mechanism governing the self-
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Fioravanti, Andrea. "Sviluppo di metodi per misure non distruttive di matrici tridimensionali di alginato." Master's thesis, Alma Mater Studiorum - Università di Bologna, 2018. http://amslaurea.unibo.it/15677/.

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L’ingegneria dei tessuti biologici mira a creare tessuti e organi sostituti, alternativi ai tradizionali trapianti. In questi termini, un biomateriale che funga da supporto (scaffold) alle cellule riveste un ruolo cruciale nel guidarne l’adesione e la crescita per la produzione di nuovo tessuto. Polimeri naturali quali gli idrogel hanno ricevuto particolare attenzione negli ultimi anni a causa della loro maggiore similarità strutturale alla matrice extracellulare. Molti metodi di fabbricazione di scaffold prevedono che le cellule siano seminate in superficie, a seguito alla generazione della s
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50

Cardoso, Guinea Brasil Camargo 1986. "Matriz tridimensional polimérica com adição de cerâmicas para reconstruções ósseas." [s.n.], 2010. http://repositorio.unicamp.br/jspui/handle/REPOSIP/263267.

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Orientadores: Antonio Celso Fonseca de Arruda, Cecília Amélia de Carvalho Zavaglia<br>Dissertação (mestrado) - Universidade Estadual de Campinas, Faculdade de Engenharia Mecânica<br>Made available in DSpace on 2018-08-16T09:25:08Z (GMT). No. of bitstreams: 1 Cardoso_GuineaBrasilCamargo_M.pdf: 3592565 bytes, checksum: f97086f3c3d7b2f1c44e717c77abe11f (MD5) Previous issue date: 2010<br>Resumo: A engenharia tecidual, que tem como objetivo a reconstrução de tecidos de animais, enfrenta um desafio: a construção de suportes. Uma das propriedades relevantes desse eventual material é a sua taxa de a
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