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1

Bouletreau, Pierre, and Christian Paulus. "Surgical correction of transverse skeletal abnormalities in the maxilla and mandible." International Orthodontics 10, no. 3 (September 2012): 261–73. http://dx.doi.org/10.1016/j.ortho.2012.06.007.

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2

Asif, Samra, Hassaan Bin Babar, Fatima Kamal, Kanwal Sohail, and Amber Kiyani. "Prevalence of Radiographic Anomalies and Abnormalities on Panoramic Films in the Pakistani Population." Journal of the Pakistan Dental Association 30, no. 02 (May 29, 2021): 124–29. http://dx.doi.org/10.25301/jpda.302.124.

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OBJECTIVES: Orthopantomogram (OPG) is a dental radiograph that captures the maxillofacial region in a single image for quick assessment of the dental arches and their surrounding structures. It can be used for treatment planning and analysis of jaw-related pathologies. Prior studies have demonstrated geographical variations in radiographic anomalies and pathologies, our purpose was to establish baseline statistics for the Pakistani population, so the Pakistani dentists are able to distinguish between anomalies and pathologies and provide appropriate care when needed. METHODOLOGY: A cross-sectional study design was used to analyze de-identified 2411 OPGs taken for routine dental care at the dental clinics of Riphah International University. These were broadly classified according to site. Data was documented on SPSS version 22 and presented as frequencies. RESULTS: From a total of 2,411 OPGs, 2326 met the inclusion criteria. The mean age of the patients was 29.06±17.99 years. Our findings included pneumatization of the maxillary sinus in 9.8%, pathological findings in the sinus in 3.9%, deflected nasal septum in 7.5%, alveolar bone loss in 32.7%, elongated styloid process in 12.1%, pathological finding associated with maxillary bone in 1.4% and mandibular bone in 2.1%. CONCLUSIONS: Our results were somewhat unique when compared with studies from other geographical locations. We established baseline statistics about the common anomalies and abnormalities noted in dental radiographs for the Pakistani population. KEY WORDS: Orthopantomogram, anomalies, mandible, maxilla
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3

Molska, Magdalena, Jagoda Janiszewska, Marcin Mikołajczyk, and Konrad Małkiewicz. "Solitary median maxillary central incisor – case report." Forum Ortodontyczne 14, no. 4 (December 29, 2018): 333–43. http://dx.doi.org/10.5604/01.3001.0012.9896.

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Solitary Median Maxillary Central Incisor Syndrome (SMMCI Syndrome) is a rare developmental disorder consisting of morphological defects that mainly affect structures in the midline of the body. The aetiology of this syndrome has not been fully explained, and SMMCI syndrome is observed more frequently in females. The presence of a solitary median maxillary incisor in the midline of the maxilla is a typical trait in the stomatognathic system, and this anomaly is found in both deciduous and permanent dentition. Regarding developmental abnormalities accompanying a solitary incisor with an atypical structure, the most common ones include: lack of the frenulum of the upper lip, deformations in the nasal cavity and cranial base, heart defects, cleft lip and palate, and mental disability of various severity. <b>Aim.</b> The aim of this work is to present the characteristic traits of a solitary median maxillary central incisor syndrome on the basis of a case study of a 9-yearold female patient and the analysis of available literature. <b>Material and methods.</b> The literature review was performed using the PubMed database and the following key words: incisor, maxilla, syndrome, development, SMMCI syndrome. <b>Case report.</b> When the clinical examination and medical history were performed the patient was diagnosed with signs of solitary median maxillary central incisor syndrome. The outcomes of a computed tomography scan confirmed choanal stenosis. Except for allergies to animal hair and grass, the patient did not suffer from any systemic diseases. On the basis of a clinical examination and analysis of additional tests the following diagnosis was made: I skeletal class, complete distocclusion with incisor protrusion, partial lateral bilateral cross bite and dental abnormalities. <b>Summary.</b> Patients diagnosed with SMMCI syndrome often require complex care provided by specialists from various fields of medicine and dentistry, due to the possibility of coexistence of numerous developmental abnormalities involving different body structures.
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4

Sousa, R., R. Tavares, and C. Lins. "Fibrous dysplasia of the maxilla: a case report." Journal of Morphological Sciences 33, no. 01 (January 2016): 037–40. http://dx.doi.org/10.4322/jms.067514.

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Abstract Introduction: Fibrous dysplasia is a benign bone lesion characterized by replacement of normal bone by fibrous connective tissue, and its diagnosis is based on clinical, radiological and histological findings. Objective: The aim of this study was to report a case of unilateral fibrous dysplasia in the maxilla, in the palate region, by using computed tomography. Results: On examination it was observed: a nodular lesion, with similar staining to the palatal mucosa with varicosities, regular edges, irm and painless. The radiographic indings on computed tomography showed one diffuse and heterogeneous thickening of the bony elements involving the hard palate extending to the posterior wall of the maxillary antrum. We opted for the preservation of the case, considering the age of the patient, the absence of facial asymmetry and lack of aesthetic and functional impairment. Conclusion: Thus, we emphasize that the knowledge of morphological changes is important for the diagnosis of bone pathologies, and the dentist must be familiar with the normal morphology of the structures and their possible abnormalities.
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5

Seabra, Mariana, Paula Vaz, Francisco Valente, Ana Braga, and António Felino. "Two-Dimensional Identification of Fetal Tooth Germs." Cleft Palate-Craniofacial Journal 54, no. 2 (March 2017): 166–69. http://dx.doi.org/10.1597/14-128.

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Objective To demonstrate the efficiency and applicability of two-dimensional ultrasonography in the identification of tooth germs and in the assessment of potential pathology. Design Observational, descriptive, cross-sectional study. Setting Prenatal Diagnosis Unit of Centro Hospitalar de Vila Nova de Gaia / Espinho–Empresa Pública in Portugal. Patients A total of 157 white pregnant women (median age, 32 years; range, 14 to 47 years) undergoing routine ultrasound exams. Main Outcome Measure(s) Description of the fetal tooth germs, as visualized by two-dimensional ultrasonography, including results from prior fetal biometry and detailed screening for malformations. Results In the first trimester group, ultrasonography identified 10 tooth germs in the maxilla and 10 tooth germs in the mandible in all fetuses except for one who presented eight maxillary tooth germs. This case was associated with a chromosomal abnormality (trisomy 13) with a bilateral cleft palate. In the second and third trimesters group, ultrasonography identified a larger range of tooth germs: 81.2% of fetuses showed 10 tooth germs in the maxilla and 85.0% of fetuses had 10 tooth germs in the mandible. Hypodontia was more prevalent in the maxilla than in the mandible, which led us to use qualitative two-dimensional ultrasonography to analyze the possible association between hypodontia and other variables such as fetal pathology, markers, head, nuchal, face, and spine. Conclusions We recommend using this method as the first exam to evaluate fetal morphology and also to help establish accurate diagnosis of abnormalities in pregnancy.
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6

Leszczyszyn, Anna, Sylwia Hnitecka, and Marzena Dominiak. "Could Vitamin D3 Deficiency Influence Malocclusion Development?" Nutrients 13, no. 6 (June 21, 2021): 2122. http://dx.doi.org/10.3390/nu13062122.

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The abnormal growth of the craniofacial bone leads to skeletal and dental defects, which result in the presence of malocclusions. Not all causes of malocclusion have been explained. In the development of skeletal abnormalities, attention is paid to general deficiencies, including of vitamin D3 (VD3), which causes rickets. Its chronic deficiency may contribute to skeletal malocclusion. The aim of the study was to assess the impact of VD3 deficiency on the development of malocclusions. The examination consisted of a medical interview, oral examination, an alginate impression and radiological imaging, orthodontic assessment, and taking a venous blood sample for VD3 level testing. In about 42.1% of patients, the presence of a skeletal defect was found, and in 46.5% of patients, dentoalveolar malocclusion. The most common defect was transverse constriction of the maxilla with a narrow upper arch (30.7%). The concentration of vitamin 25 (OH) D in the study group was on average 23.6 ± 10.5 (ng/mL). VD3 deficiency was found in 86 subjects (75.4%). Our research showed that VD3 deficiency could be one of an important factor influencing maxillary development. Patients had a greater risk of a narrowed upper arch (OR = 4.94), crowding (OR = 4.94) and crossbite (OR = 6.16). Thus, there was a link between the deficiency of this hormone and the underdevelopment of the maxilla.
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7

Sulabha, AN, and C. Sameer. "A rare case of multiple dental anomalies in non syndromic patient." Bangladesh Journal of Medical Science 13, no. 1 (December 25, 2013): 95–98. http://dx.doi.org/10.3329/bjms.v13i1.17444.

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Human dental anomalies are formative defects to variety of genetic and environmental factors. Multiple anomalies are seen in patient with chromosomal abnormalities or specific syndromes. Multiple odontogenic anomalies in non syndromic patient are unusual and rare. This paper reports a rare, unique and interesting case of multiple odontogenic anomalies such as bilateral macrodontia of maxillary central incisor, hypodontia, hyperdontia in lower anterior mandible, transposition in left anterior maxilla and taurodontism with molars in a single non syndromic young Indian female patient. Patients with multiple dental anomalies require multidisplinary treatment approaches such as surgical, orthodontic, endodontic, prosthodontic rehabilitation etc. Multiple dental anomalies in non syndromic patient are rare and needs early diagnosis and require multidisplinary approach. DOI: http://dx.doi.org/10.3329/bjms.v13i1.17444 Bangladesh Journal of Medical Science Vol. 13 No. 01 January2014: 95-98
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8

Sun, Ming, Na Lv, Ya Xiao, Jiabin Li, and Guangzhao Guan. "A rare case of accessory maxilla: a case report and literature review of Tessier no. 7 clefts." Journal of International Medical Research 48, no. 5 (May 2020): 030006052092568. http://dx.doi.org/10.1177/0300060520925680.

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Bilateral Tessier no. 7 clefts are rarely reported in the literature. Here, we describe the presence of accessory maxilla with supernumerary teeth in a patient who exhibited bilateral Tessier no. 7 clefts; the diagnosis was established based on the patient’s history, clinical presentation, and computed tomography images. A review of the available literature revealed 24 patients with Tessier no. 7 clefts from 2000 to 2020, including our patient. The most common clinical manifestation in patients with Tessier no. 7 clefts comprises bilateral facial clefts. Additionally, Tessier no. 7 clefts are more frequently found in boys or men, rather than in girls or women. The presence of an accessory maxilla with supernumerary teeth in a patient with bilateral Tessier no. 7 clefts is extremely rare. Early detection of craniofacial abnormalities is important, because it may influence patient prognosis and management.
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9

Driesen, A., S. Malberg, M. Kramer, C. Thiel, and S. Kaiser. "Treatment of a periorbital cyst in a dog by creation of a permanent drainage opening." Tierärztliche Praxis Ausgabe K: Kleintiere / Heimtiere 43, no. 06 (2015): 421–26. http://dx.doi.org/10.15654/tpk-140927.

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SummaryAn inflammatory periorbital cyst with secondary pressure atrophy of the maxilla was treated by surgical creation of a drainage opening to the nasal cavity in a 4-year-old Yorkshire Terrier. Following treatment, clinical signs resolved and computed tomography 5 weeks after surgery confirmed the permanence of the drainage opening. Eight months later, the dog showed no clinical abnormalities. Therefore, the procedure described in this report may offer a suitable treatment option in cases where the cyst’s size or localization prevents complete excision.
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10

Kumar Jena, Dr Ashok, and Dr Om Kharbanda. "Axenfeld-Rieger Syndrome: Report on dental and craniofacial findings." Journal of Clinical Pediatric Dentistry 30, no. 1 (September 1, 2006): 83–88. http://dx.doi.org/10.17796/jcpd.30.1.v1732398454r0244.

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Axenfeld-Rieger syndrome is a rare autosomal dominant disorder characterized by various ocular and extraocular malformations. Dental abnormalities are considered as definitive features for the diagnosis and differentiation of Rieger syndrome from other anterior chamber of the eye malformations. A case of Rieger syndrome with distinct dental and craniofacial anomalies is described. Significant cranio-dento-facial findings that have been observed are, teeth with short and dilacerated roots, hyperplastic frenums and underdeveloped maxilla. There was an anterior crossbite, bilateral posterior openbite and moderate to severe anterior crowding.
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11

Aghili, Hossein, Seyed Mohammad Ali Tabatabaei, and Mahdjoube Goldani Moghadam. "Clinical and Radiographic Features of Pycnodysostosis with Emphasis on Dentofacial Problems." Case Reports in Dentistry 2017 (2017): 1–5. http://dx.doi.org/10.1155/2017/4352485.

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Pycnodysostosis (PDO) is a rare genetic disorder characterized by cathepsin K deficiency which plays an important role in bone metabolism. Among clinical features of this disease which are mainly caused by altered bone remodeling are craniofacial abnormalities such as hypoplastic maxilla and obtuse gonial angle which consequently lead to respiratory insufficiency in forms of pharyngeal narrowing and severe snoring. In this paper, another case of this rare disorder is presented along with a review on etiology and management issues of respiratory insufficiency in these patients.
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12

Bandarra, Paulo M., Saulo P. Pavarini, Adriana S. Santos, Nadia Aline B. Antoniassi, Cláudio E. F. Cruz, and David Driemeier. "Nutritional fibrous osteodystrophy in goats." Pesquisa Veterinária Brasileira 31, no. 10 (October 2011): 875–78. http://dx.doi.org/10.1590/s0100-736x2011001000007.

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Seven out of 25 goats from a southern Brazilian flock developed nutritional fibrous osteodystrophy. Affected animals were younger than 1 year of age and were confined in stalls and fed a concentrate ration containing 1:6 calcium:phosphorus ratio. The remaining flock (35 goats) was managed at pasture and showed no disease. Clinical signs were characterized by mandibular and maxillary enlargements, varying degrees of mouth opening and protruding tongue, dyspnea, apart of abnormalities of prehension and mastication. Affected animals had increased seric levels of phosphorus and parathormone, as well as higher alkaline phosphatase activity. Postmortem examination on three succumbed goats revealed bilateral enlargement of the maxilla and mandibula, and loose teeth, apart of multiple incomplete rib fractures in one of them. Severe diffuse proliferation of loose connective tissue surrounded the osteoid trabeculae, many of which were partially or completely non-mineralized. Mineralized osteoid trabeculae showed osteoclasts in the Howship's lacunae.
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13

Melo, de, do Boechat, Silva Coutinho, Cardoso Silveira, and Cavalcanti Leite. "Klipplel-Trénaunay-Weber syndrome: A case report." Serbian Dental Journal 56, no. 2 (2009): 97–101. http://dx.doi.org/10.2298/sgs0902097m.

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Klippel-Tr?naunay-Weber Syndrome (KTWS) is a rare congenital malformation that may include port-wine stain, soft tissue and bony hypertrophy, and venous malformations and lymphatic abnormalities. The oral findings include an enlarged maxilla, gingival enlargement, malocclusion and premature tooth eruption. This report describes a case of gingival enlargement in an 8-year-old male child with KTWS. The extraoral clinical examination revealed discrete hemifacial hypertrophy on the left side and hyperpigmented spots on the anterior region of the neck, left arm and left leg. The intraoral clinical examination showed a deep palate and enlarged buccal and palatal gingiva in the anterior maxilla. Complete blood count and all general medical examinations showed values within normal range while the psychological evaluation indicated a mild learning delay. Although it rarely involves the orofacial region, KTWS should be included in the differential diagnosis of severe gingival enlargement. In view of the potentially dangerous complications that can arise, it is imperative the dental surgeon has a thorough knowledge of this condition and its management.
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14

Lai, Moon Cheung, Nigel M. King, and Hai Ming Wong. "Abnormalities of Maxillary Anterior Teeth in Chinese Children with Cleft Lip and Palate." Cleft Palate-Craniofacial Journal 46, no. 1 (January 2009): 58–64. http://dx.doi.org/10.1597/07-077.1.

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Objective: To retrospectively study the anterior maxilla of southern Chinese children with complete cleft lip and palate (CLP) for the prevalence of different kinds of dental anomalies, position and rotation of the teeth, and the asymmetry of dental development. Patients: 195 southern Chinese children with CLP aged between 3 and 17 years. Methods and Materials: Dental records and study casts were studied as were the radiographs from which the dental development was determined. Results: The tooth prevalence of cleft side permanent lateral incisor was 19.2% in unilateral CLP (UCLP) children and 20.5% in bilateral CLP (BCLP) children. The cleft side central incisors were rotated in 78.1% and 95.9% of the teeth in UCLP and BCLP children, respectively. Of the permanent canines, 43.4% were positioned mesially on the cleft side in UCLP children, while for BCLP children 69.7% of the teeth were in a normal position. In addition, the mesially positioned canines were often associated with an absence of the permanent lateral incisor while the distally positioned canines were always associated with the presence of supernumeraries in the cleft region. The permanent teeth on the cleft side showed significantly delayed development compared with their antimeres on the noncleft side; however, the delayed permanent lateral incisors did complete their formation normally. Conclusion: This group of Chinese children with CLP demonstrated statistically significant higher prevalences of hypodontia, microdontia, and delayed dental development on the cleft side than the noncleft side.
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15

Tortora, Chiara, Maria C. Meazzini, Giovanna Garattini, and Roberto Brusati. "Prevalence of Abnormalities in Dental Structure, Position, and Eruption Pattern in a Population of Unilateral and Bilateral Cleft Lip and Palate Patients." Cleft Palate-Craniofacial Journal 45, no. 2 (March 2008): 154–62. http://dx.doi.org/10.1597/06-218.1.

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Objective: To evaluate the dental characteristics of patients subjected to a protocol that included early secondary gingivoalveoloplasty (ESGAP). Design: Panoramic radiographs of 87 patients with unilateral cleft lip and palate (UCLP) and 29 with bilateral cleft lip and palate (BCLP) were evaluated. Missing and supernumerary teeth were also quantified on the cleft and noncleft side and in the maxilla and mandible. Crown and root malformations and tooth rotations were quantified. A subsample in permanent dentition was extrapolated to analyze canine eruption patterns. Results: A total of 48.8% of the UCLP patients presented with missing permanent lateral incisors in the cleft area and 6.1% contralaterally. A total of 4.9% presented with missing second maxillary premolars on the cleft site and 1.2% contralaterally. A total of 7.3% presented with supernumerary lateral incisors, and 45% of the BCLP cleft sites presented with missing lateral incisors, while 25% of the cleft sites presented second maxillary premolars agenesis. Five percent of the cleft sites presented with supernumerary lateral incisors. Evaluation of the subsample in permanent dentition showed that 15.5% had a canine retention and 4.4% of the canines had to be surgically exposed. A significant association was observed between canine inclination and retention but not with absence of the lateral incisor. Conclusions: The frequency of dental anomalies in this sample was similar to other cleft populations. As surgical trauma has been suggested to damage forming teeth, the results of this study indicated that ESGAP has no detrimental influence on subsequent dental development.
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Farronato, Giampietro, Cinzia Maspero, Davide Farronato, and Silvia Gioventù. "Orthodontic Treatment in a Patient with Cleidocranial Dysostosis." Angle Orthodontist 79, no. 1 (January 1, 2009): 178–85. http://dx.doi.org/10.2319/111307-393.1.

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Abstract Cleidocranial dysostosis is a rare congenital skeletal disorder, associated with clavicular hypoplasia or aplasia, delayed closure of cranial fontanels, brachycephalic skull, delayed exfoliation of primary dentition, eruption of permanent teeth, and multiple supernumerary and morphologic abnormalities of the maxilla and mandible. The disorder is caused by mutation in the CBFA1 gene, on the short arm of chromosome 6p21. The prevalence of cleidocranial dysostosis is estimated one per million, without sex or ethnic group predilection. The purpose of this paper is to describe the orthodontic treatment in a patient with cleidocranial dysostosis. Therapy may include removal of supernumerary teeth, surgical exposure of impacted teeth, and orthodontic treatment.
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17

Koka, Venkata, Sandrine Baron, Darius Abedipour, Vincent Latournerie, and Pierre El Chater. "EK Sign: A Wrinkling of Uvula and the Base of Uvula in Obstructive Sleep Apnea-Hypopnea Syndrome." Sleep Disorders 2015 (2015): 1–4. http://dx.doi.org/10.1155/2015/749068.

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Introduction. Diagnosis of obstructive sleep apnea-hypopnea syndrome (OSAHS) is suspected in the presence of symptoms and/or pharyngeal alterations and skeletal abnormalities of maxilla and mandible. Our aim is to find a new clinical sign that leads to suspicion of OSAHS in snorers.Methods. We reviewed the clinical data of 69 snoring patients with or without OSAHS. We defined EK sign as the presence of horizontal wrinkling of uvula and the base of uvula and tried to correlate its presence with OSAHS.Results. EK sign was present in 25 of 69 patients. The positive predictive value of EK sign is 100%. The presence of EK sign significantly correlated with OSAHS (44% if AHI ≥ 5 and 0% if AHI < 5;p= 0.01) and severity of OSAHS (7% if AHI < 15 and 58% with AHI ≥ 15;p< 0.001).Conclusions. The EK sign is a strong predictor of OSAHS with a specificity of 100%. We recommend performing sleep tests in presence of EK sign in snorers even in the absence of other abnormalities or symptoms.
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18

Hines, Elizabeth S., Valentina B. Stevenson, Molly E. Patton, Hannah R. Leventhal, Noah Diaz-Portalatin, Mitchell A. Meyerhoeffer, Linda A. Dahlgren, and D. Phillip Sponenberg. "Fibrous osteodystrophy in a dromedary camel." Journal of Veterinary Diagnostic Investigation 33, no. 1 (October 14, 2020): 144–48. http://dx.doi.org/10.1177/1040638720965252.

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A 6-y-old female dromedary camel ( Camelus dromedarius L.) was presented for assessment of firm, bilateral swellings rostral and ventral to the eyes. Serum biochemistry revealed hyperglycemia (28.5 mmol/L), hypocalcemia (1.27 mmol/L), hyperphosphatemia (3.39 mmol/L), hypoproteinemia (total protein 50 g/L), and hypoalbuminemia (20 g/L). Based on the poor prognosis associated with the presumptive diagnosis of fibrous osteodystrophy, the camel was euthanized. Gross postmortem findings revealed expanded fibrous tissue replacing the maxilla and mandible, and bilaterally prominent parathyroid glands. Histology of the maxilla revealed proliferative loose fibrous tissue with widely scattered, regularly spaced, small spicules of mineralized bone. The parathyroid glands were prominent bilaterally; the internal and external parathyroid glands were composed of plump cells with abundant pale basophilic cytoplasm and open nuclei. The pathologic findings were consistent with the antemortem diagnosis of fibrous osteodystrophy. The camel’s diet, which was not specifically balanced for a camel, included grass hay, sweet feed, and alfalfa pellets. The camel’s caregivers reported feeding her treats of cookies. A feed analysis was not available. The biochemistry abnormalities and clinical and postmortem findings, along with a diet that was not balanced for a camel, are consistent with a diagnosis of nutritional secondary hyperparathyroidism.
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Ferguson, J. W., R. I. Evans, and L. H. Cheng. "Diagnostic accuracy and observer performance in the diagnosis of abnormalities in the anterior maxilla: a comparison of panoramic with intraoral radiography." British Dental Journal 173, no. 8 (November 1992): 265–71. http://dx.doi.org/10.1038/sj.bdj.4808024.

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Casey, Kerriann M., Caitlin J. Karanewsky, Jozeph L. Pendleton, Mark R. Krasnow, and Megan A. Albertelli. "Fibrous Osteodystrophy, Chronic Renal Disease, and Uterine Adenocarcinoma in Aged Gray Mouse Lemurs (Microcebus murinus)." Comparative Medicine 71, no. 3 (June 1, 2021): 256–66. http://dx.doi.org/10.30802/aalas-cm-20-000078.

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The gray mouse lemur (Microcebus murinus, GML) is a nocturnal, arboreal, prosimian primate that is native to Madagascar. Captive breeding colonies of GMLs have been established primarily for noninvasive studies on questions related to circadian rhythms and metabolism. GMLs are increasingly considered to be a strong translational model for neurocognitive aging due to overlapping histopathologic features shared with aged humans. However, little information is available describing the clinical presentations, naturally occurring diseases, and histopathology of aged GMLs. In our colony, a 9 y-old, male, GML was euthanized after sudden onset of weakness, lethargy, and tibial fracture. Evaluation of this animal revealed widespread fibrous osteodystrophy (FOD) of the mandible, maxilla, cranium, appendicular, and vertebral bones. FOD and systemic metastatic mineralization were attributed to underlying chronic renal disease. Findings in this GML prompted periodic colony-wide serum biochemical screenings for azotemia and electrolyte abnormalities. Subsequently, 3 additional GMLs (2 females and 1 male) were euthanized due to varying clinical and serum biochemical presentations. Common to all 4 animals were FOD, chronic renal disease, uterine adenocarcinoma (females only), cataracts, and osteoarthritis. This case study highlights the concurrent clinical and histopathologic abnormalities that are relevant to use of GMLs in the expanding field of aging research.
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Al Hasani, Khamis M., Abdulaziz A. Bakathir, Ahmed K. Al-Hashmi, Badar Al Rawahi, and Abdullah Albakri. "Modified Le Fort I Osteotomy and Genioplasty for Management of Severe Dentofacial Deformity in β-Thalassaemia Major: Case report and review of the literature." Sultan Qaboos University Medical Journal [SQUMJ] 20, no. 3 (October 5, 2020): 362. http://dx.doi.org/10.18295/squmj.2020.20.03.018.

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β-thalassaemia major is an autosomal recessive form of haemoglobinopathy that is characterised by complete lack of production of the β-chains resulting in multiple complications that include severe anaemia, failure to thrive and skeletal abnormalities. Facial deformities induced by β-thalassaemia major are rare and are very challenging to treat from a surgical point of view. We report a 33-year-old female patient with β-thalassaemia major who presented to the Dental & Maxillofacial Surgery Department, Sultan Qaboos University Hospital, Muscat, Oman, in 2017 with gross dentofacial skeletal deformity contributing to her psychosocial issues. The facial deformity was corrected surgically by excision of the enlarged maxilla, modified Le Fort I osteotomy and advancement genioplasty. This case highlights the pre-operative preparation, surgical management, encountered complications and treatment outcome within 24 months of follow-up.Keywords: Beta-Thalassaemia; Thalassaemia Major; Cooley's Anemia; Le Fort Osteotomy; Genioplasty; Dentofacial Deformities; Case Report; Oman.
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Sarma, Vivek Parameswara. "Median cleft lip: an uncommon and unique anomaly." International Surgery Journal 6, no. 8 (July 25, 2019): 3035. http://dx.doi.org/10.18203/2349-2902.isj20193369.

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Median or midline cleft lip [MCL] is an uncommon anomaly characterized by a midline vertical cleft through the upper lip and are either isolated or part of multiple anomalies. It can involve the pre-maxilla, the nasal septum, and the central nervous system. MCL includes Complete (42%), Incomplete (49%), and Minor forms (9%). The three main groups distinguished were: 1. Isolated MCL; 2. MCL with craniofacial malformations; and 3. MCL with extra-facial malformations. To analyze two operated cases of median cleft lip and review the relevant literature. The details of two cases of median cleft lip that were operated in 2017 were analysed. Both cases underwent wedge excision with the classical inverted V incision and muscle reconstruction with satisfactory result. Both the patients had no syndromic association or associated anomaly. All cases of MCL require evaluation for associated abnormalities. Isolated MCL can be repaired surgically with a good outcome.
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23

Ceyhan, Derya, and Burcu Gucyetmez Topal. "An 18-Month-Old Child with Infantile Pompe Disease: Oral Signs." Case Reports in Dentistry 2017 (2017): 1–3. http://dx.doi.org/10.1155/2017/5685941.

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We aim to create an information platform by contributing orodental findings of Pompe disease to literature. An 18-month-old male patient with Pompe disease was referred to our clinic due to swelling of the gums. In first dental examination, a nonfluctuant, normal gingiva colored swelling at the right anterior region of maxilla was detected. His parents were recommended to perform finger massage to the region. Six months later, 51, 52, 62, and 74 numbered teeth had erupted, there was a fusion between 51 and 52 numbered teeth, 84 numbered tooth was seen to be erupted, and a swelling at the site of this tooth, similar to previous one, was present. Finger massage was recommended for this area as well, and the swelling was found to have decreased at the follow-up, one week later. Tooth eruption problems and developmental dental abnormalities should be included in the signs for Pompe disease.
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Tsuiki, Satoru, Shiroh Isono, Teruhiko Ishikawa, Yoshihiro Yamashiro, Koichiro Tatsumi, and Takashi Nishino. "Anatomical Balance of the Upper Airway and Obstructive Sleep Apnea." Anesthesiology 108, no. 6 (June 1, 2008): 1009–15. http://dx.doi.org/10.1097/aln.0b013e318173f103.

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Background Obesity and craniofacial abnormalities such as small maxilla and mandible are common features of patients with obstructive sleep apnea (OSA). The authors hypothesized that anatomical imbalance between the upper airway soft-tissue volume and the craniofacial size (rather than each alone) may result in pharyngeal airway obstruction during sleep, and therefore development of OSA. Methods Blind measurements of tongue cross-sectional area and craniofacial dimensions were performed through lateral cephalograms in 50 adult male patients with OSA and 55 adult male non-OSA subjects with various craniofacial dimensions. Results Maxillomandibular dimensions were matched between OSA and non-OSA groups. While the tongue was significantly larger in subjects with larger maxillomandible dimensions, OSA patients had a significantly larger tongue for a given maxillomandible size than non-OSA subjects. The hypothesis was also supported in subgroups matched for both body mass index and maxillomandible dimensions. Conclusions Upper airway anatomical imbalance is involved in the pathogenesis of OSA.
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Ceylan, Gözlem, Nergiz Yılmaz, Özgün Şenyurt, and Göknil Ergün Kunt. "Implant Supported Prosthesıs in a Patıent wıth Progerıa: Case Report." Bosnian Journal of Basic Medical Sciences 9, no. 3 (August 20, 2009): 210–14. http://dx.doi.org/10.17305/bjbms.2009.2808.

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Prosthodontic rehabilitation can be accomplished with fixed, overdenture, complete, or implant-retained prostheses. Dental treatment overcomes the patient’s functional, psychological, esthetic and phonation problems. Remaining healthy teeth may allow the dentist to fabrícate a removable partial overdenture, fixed partial prosthesis or implant - supported prosthesis. The retention of a number of abutments helps maintain a positive ridge form with greater height and volume of the alveolar bone, improving masticatory performance, as well as providing a more stable prostheses. Dental patients who have medical problems need many treatment procedures. Multidisciplinary treatment planning is invaluable for patient’s dental health. Progeria is a rare genetic condition where symptoms resembling aspects of aging are manifested at an early age. characteristic clinical findings of Progeria disease include abnormalities of the skin and hair in conjunction with char-acteristic facial features and skeletal abnormalities. The characteristic facies show protruding ears, beaked nose, thin lips with centrofacial cyanosis, prominent eyes, frontal and parietal bossing with pseudohydrocephaly, midface hypoplasia with micrognathia and large anterior fontanel. The other reported anomalies are dystrophic nails, hypertrophic scars and hypoplastic nipples. The findings that are nearly interested in dentistry are delayed dentition, anodontia, hypodontia, or crowding of teeth. This article presents the multidisciplinary dental treatment planning includes surgical, endodontic and prosthetic treatment of a patient with a history of progeria. In this case complete-arch fixed prostheses in both maxilla and mandible, supported by a combination of im-plants and teeth are reported.
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Makarova, О. М. "DIAGNOSTIC CRTITERIA OF ORTHODONTIC TREATMENT WITH EXTRACTION OF SOME TEETH." Medical and Ecological Problems 23, no. 3-4 (June 19, 2019): 13–16. http://dx.doi.org/10.31718/mep.2019.23.3-4.04.

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Orthodontic treatment for adults is always difficult process, which requires morphological, functional, aesthetic factors and limited possibilities of dentoalveolar teeth positioning. One of the most actual issues of orthodontic correction in adults is teeth extractions by orthodontic. Nowadays, when there is a concept of «arch development», skeletal enlargement and miniimplants, treatment with extraction should be correctly explained and determined by orthodontic treatment and should not be caused to functional status and face aesthetics, which provides qualitative and stabile result of treatment. Besides, necessity of teeth extraction of some teeth which are written in medical protocol, secures a doctor from law risks. The aim of the investigation was to establish correlative link between parameters of morphometric analysis of control and diagnostic models of jaws by Snagina and roentgenologic parameters of lateral cephalometry by Kim. Adult patients aged from 18 to 32 years old (50) by the 1st class of dentofacial abnormalities and the degree of teeth crowding were involved in the investigation. Results. Indications to treatment with teeth extraction by skeletal and dentoalveolar parameters are different, although there is connection between skeletal parameters and the width of apical basis of maxilla. Skeletal and dentoalveolar morphometric parameters that are used for evaluation of extraction necessity of some teeth and planning for orthodontic treatment is always individual. Done correlation analysis determined that single parameter of apical basis that correlates with CF is its width on the maxilla. CF has direct correlative connection of midline (r=0.52) with width of apical basis. Skeletal diagnosis and facial aesthetics is leading factor in modern orthodontics. During treatment plan one should orient into aesthetic and functional prognosis, structure of facial skeleton, and after that dentoalveolar parameters.
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Dabovic, Branka, Yan Chen, Cristina Colarossi, Hiroto Obata, Laura Zambuto, Mary Ann Perle, and Daniel B. Rifkin. "Bone abnormalities in latent TGF-β binding protein (Ltbp)-3–null mice indicate a role for Ltbp-3 in modulating TGF-β bioavailability." Journal of Cell Biology 156, no. 2 (January 14, 2002): 227–32. http://dx.doi.org/10.1083/jcb.200111080.

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The TGF-βs are multifunctional proteins whose activities are believed to be controlled by interaction with the latent TGF-β binding proteins (LTBPs). In spite of substantial effort, the precise in vivo significance of this interaction remains unknown. To examine the role of the Ltbp-3, we made an Ltbp-3–null mutation in the mouse by gene targeting. Homozygous mutant animals develop cranio-facial malformations by day 10. At 2 mo, there is a pronounced rounding of the cranial vault, extension of the mandible beyond the maxilla, and kyphosis. Histological examination of the skulls from null animals revealed ossification of the synchondroses within 2 wk of birth, in contrast to the wild-type synchondroses, which never ossify. Between 6 and 9 mo of age, mutant animals also develop osteosclerosis and osteoarthritis. The pathological changes of the Ltbp-3–null mice are consistent with perturbed TGF-β signaling in the skull and long bones. These observations give support to the notion that LTBP-3 is important for the control of TGF-β action. Moreover, the results provide the first in vivo indication for a role of LTBP in modulating TGF-β bioavailability.
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Md Anisuzzaman, Mostafa, Safiquer Rahman Khan, Mohammad Tariqul Islam Khan, Md Kamal Abdullah, and Alia Afrin. "Evaluation of Mandibular Condylar Morphology By Orthopantomogram In Bangladeshi Population." Update Dental College Journal 9, no. 1 (April 27, 2019): 29–31. http://dx.doi.org/10.3329/updcj.v9i1.41203.

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Background: Orthopantomograph (OPG) is one of the most common radiograph use by dental surgeon for evaluate information about teeth, Maxilla, Mandible and other bony structure. It is also available, low price and low doses of radiation. Mandibular condyle is most important landmarks of mandible, which is changes due to ageing process, developmental abnormalities, distinct diseases, trauma, endocrine shock, radio therapy etc. Panoramic radiographs remain the best screening modality for temporomandibular joint abnormalities today. Objectives: The aims at objective of observing and documentation of shapes of condyle on an orthopantomogram, which were very important for treatment of patient in different branch of dentistry specially in oral and maxillofacial surgery. Materials and Methods: This study composed radiographic evaluation of 500 condylar heads after imaging 250 digitalized OPGs taken for analysis. Then evaluate the mandibular condylar shape in 2D dimensional view (OPG). Results: In our study, an attempt to common prevalent radiographic shapes of the condylar head on the OPG. 200 pairs of condylar heads were evaluated. Out of them 60% were oval in shape, followed by bird beak (29%), diamond (9%) and least being crooked finger (2%). Oval-oval was commonly occurring mix (67%), whereas crooked/ crooked finger was a rarity. Conclusion: Due to low radiation exposer and availability, OPG is common chose of dentist for primary evaluate the tooth, mandible and facial skeleton. Shapes of the mandibular condyle also evaluate by OPG which showing ovaloval being most accepted in both genders. Update Dent. Coll. j: 2019; 9 (1): 29-31
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Witt, Peter D., Robert A. Hardesty, Craig Zuppan, Glenn Rouse, Anton N. Hasso, and Philip Boyne. "Fetal Kleeblattschädel Cranium: Morphologic, Radiographic, and Histologic Analysis." Cleft Palate-Craniofacial Journal 29, no. 4 (July 1992): 363–68. http://dx.doi.org/10.1597/1545-1569_1992_029_0363_fkdcmr_2.3.co_2.

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The kleeblattschädel deformity is a rare craniofacial condition typified by its trilobed, cloverleaf skull. The pathophysiology of this process is controversial. The morphologic, radiographic, and histologic abnormalities identified in the cranial base of an 18-gestational-week fetus with kleeblattschädel skull have not been described previously. Recently, the intrauterine diagnosis of kleeblattschädel was established by serial ultrasonography and, based on this evidence, the fetus was aborted. The fetus was studied extensively. Standard radiographs and high-resolution CT scans were obtained. Three-dimensional, reformatted contour surface images were constructed from the CT scan data. The cranial base was examined grossly, radiographically, and histologically. Histologic microanatomic study concentrated on structures of the mid-sagittal cranial base from the occiput to the mid maxilla. The distorted cranial architecture in kleeblattschädel deformity has, in the past, been attributed largely to the cranial base deformity which secondarily distorts the developing brain. Our study, however, suggests that the calvarium itself may be the primary focus of abnormal events leading to synostosis. The findings in this study seem to be Inconsistent with earlier theories about the abnormal development of craniodysostoses.
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Xue, Xuhong, and Sheng Zhao. "Severe Kyphoscoliosis in a Patient with Goldenhar Syndrome: A Case Report." Case Reports in Orthopedic Research 1, no. 1-3 (June 7, 2018): 19–26. http://dx.doi.org/10.1159/000490066.

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Introduction: Goldenhar syndrome includes a wide spectrum of congenital anomalies involving structures arising from the first and second branchial arches. It is characterized by impaired development of structures such as eyes, ears (with or without hearing loss), lip, tongue, palate, mandible, maxilla, and deformations of vertebrae. The etiology of this syndrome is unclear since it varies genetically and is linked to a plethora of reasons. Case Report: A 13-year-old male presented to the Orthopedic Department with complaints of back bulge with bilateral microtia since birth. X-ray and computed tomography revealed severe congenital kyphoscoliosis. Posterior vertebral column resection surgery with instrumentation and anterior cage support with bone graft fusion were performed. A postoperative plain X-ray film demonstrated a good correction rate. His follow-up was asymptomatic and well balanced in the sagittal and coronal planes at 6 months following operation. Systemic involvement was clinically and radiographically assessed. Conclusion: Patients with Goldenhar syndrome due to a large variety of abnormalities and different severity of symptoms pose a challenge for clinicians. All of this necessitates an individual approach to each single patient and involvement of a team of specialists in treatment planning. Although complex scoliosis surgery could be achieved safely in Goldenhar syndrome patients, careful preoperative management is required.
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Yoneda, T., T. B. Aufdemorte, R. Nishimura, N. Nishikawa, M. Sakuda, M. M. Alsina, J. B. Chavez, and G. R. Mundy. "Occurrence of hypercalcemia and leukocytosis with cachexia in a human squamous cell carcinoma of the maxilla in athymic nude mice: a novel experimental model of three concomitant paraneoplastic syndromes." Journal of Clinical Oncology 9, no. 3 (March 1991): 468–77. http://dx.doi.org/10.1200/jco.1991.9.3.468.

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Hypercalcemia and leukocytosis may occur in conjunction as paraneoplastic syndromes associated with malignant disease. Here we describe a human squamous cell carcinoma of the maxilla that was associated with hypercalcemia and leukocytosis, and also cachexia. The primary tumor was surgically removed and established in permanent cell culture. When either primary tumors or cultured tumor cells were inoculated into nude mice, the nude mice developed the same paraneoplastic syndromes as those which occurred in the patient from whom the tumor was originally derived. The plasma calcium was increased two and one-half-fold and the WBC count 30-fold, and the body weight was decreased by 45% in tumor-bearing animals. Each of these paraneoplastic syndromes was alleviated by surgical excision of the tumor, indicating that the paraneoplastic syndromes were due to a factor or factors produced by the primary tumor. The development of each of these paraneoplastic syndromes in nude mice correlated positively with the other two syndromes. We examined the organs of tumor-bearing mice and found striking histopathologic abnormalities in the bones, spleen, and liver, but no infiltration with tumor cells. The bones showed marked evidence of osteoclastic bone resorption. This model of a human tumor associated with the hypercalcemia-leukocytosis paraneoplastic syndrome, together with cachexia, should make it possible to determine the mechanisms responsible for these paraneoplastic syndromes and their relationship to each other.
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Santos, Giancarlo, Ilana Ickow, Joici Job, Jack E. Brooker, Lucas A. Dvoracek, Erick Rigby, Nilesh Shah, Wendy Chen, Barton Branstetter, and Lindsay A. Schuster. "Cone-Beam Computed Tomography Incidental Findings in Individuals With Cleft Lip and Palate." Cleft Palate-Craniofacial Journal 57, no. 4 (January 22, 2020): 404–11. http://dx.doi.org/10.1177/1055665619897469.

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Objectives: The use of cone-beam computed tomography (CBCT) is well-established in clinical practice. This study seeks to categorize and quantify the incidental finding (IF) rate on CBCT in patients with cleft lip and palate (CLP) prior to orthodontic or surgical treatment. Methods: This is systematic retrospective review of head and neck CBCTs in patients with nonsyndromic CLP taken between 2012 and 2019 at a single tertiary referral center. All assessments were performed independently by 4 observers (a head and neck radiologist and 3 orthodontists, including 2 fellowship-trained cleft-craniofacial orthodontists ). The images were divided into 9 anatomical areas and screened using serial axial slices and 3D reconstructions. The absolute number of IFs was reported for each area and statistical analysis was performed. Results: Incidental findings were found in 106 (95.5%) of the 111 patients. The most common sites were the maxilla (87.4%, principally dental anomalies), paranasal sinuses (46.8%, principally inflammatory opacification), and inner ear cavities (18.9%, principally inflammatory opacification). Eleven patients had skull malformations. Thirty-three patients had IFs in 1 anatomical area, 49 patients in 2 anatomical areas, 19 patients in 3 areas, and 5 patients presented with IFs in 4 of the 9 anatomical areas. Discussion: In patients with CLP, IFs on CBCT exam were present in the majority of cases. Most patients with IFs had them in multiple anatomical areas of the head and neck. The maxillary dental–alveolar complex was the most common area. Inflammatory changes in the inner ear cavities and paranasal sinuses were also common; however, cervical spine and skull abnormalities were also identified. Clinicians caring for patients with CLP should be aware of IFs, which may warrant further investigation and treatment.
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Wojtaszek-Lis, Julita, Piotr Regulski, Małgorzata Laskowska, and Małgorzata Zadurska. "Effects of premature loss of deciduous teeth on the morphology and functions of the masticatory organ. Literature review." Forum Ortodontyczne 14, no. 1 (March 1, 2018): 29–47. http://dx.doi.org/10.5604/01.3001.0012.0542.

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Premature loss of a deciduous tooth is its loss 3 to 4 years before its physiological replacement, in other words – one year before the date of physiological resorption of its roots. The most common reasons for premature loss of deciduous teeth include complications of caries such as: pulp gangrene, periodontitis, inflammation of the periapical area, periapical lesions, abscesses, and osteitis. Mechanical traumas and cysts belong to other reasons. Direct consequences of premature loss of a deciduous tooth include inhibition of growth of the alveolar process bone of the maxilla or alveolar part of the mandible in the area where a tooth is missing. Presence of space in the dental arch leads to various dental displacements such as tooth displacement along the arch, rotations, inclinations. It leads to dental abnormalities, including secondary crowding, dental abnormalities associated with time and place of eruption of permanent teeth, arch midline shift, and Godon’s effect. Consequences of premature loss of deciduous teeth also include worsening of pre-existing malocclusions and dysfunctions of the masticatory organ associated with chewing, speech and swallowing. Aim. The paper aimed to present consequences of premature loss of deciduous teeth and to determine indications for prophylactic treatment. Material and methods. A review of literature in Polish and English from the period 2006–2017 was performed using PubMed, PBL, Embase, Scopus databases. “Premature loss of deciduous teeth” was a key word. Results. Consequences of premature loss of various groups of deciduous teeth were presented and indications for prophylactic treatment were discussed based on literature collected. Conclusions. The analysis performed concluded that due to various consequences of premature loss of deciduous teeth orthodontic management is recommended in many cases in order to minimise consequences of premature loss of deciduous teeth. (Wojtaszek-Lis J, Regulski P, Laskowska M, Zadurska M. Effects of premature loss of deciduous teeth on the morphology and functions of the masticatory organ. Literature review. Orthod Forum 2018; 14: 29-47)
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Wang, Weicai, Yutao Jian, Bin Cai, Miao Wang, Mu Chen, and Hongzhang Huang. "All-Trans Retinoic Acid-Induced Craniofacial Malformation Model: A Prenatal and Postnatal Morphological Analysis." Cleft Palate-Craniofacial Journal 54, no. 4 (July 2017): 391–99. http://dx.doi.org/10.1597/15-271.

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Objective To characterize the prenatal and postnatal craniofacial bone development in mouse model of all-trans retinoic acid (ATRA) exposure at different ages by a quantitative and morphological analysis of skull morphology. Methods Pregnant mice were exposed to ATRA at embryonic day 10 (E10) and 13 (E13) by oral gavage. Skulls of mice embryos at E19.5 and adult mice at postnatal day 35 (P35) were collected for high-resolution microcomputed tomography (microCT) imaging scanning and section HE staining. Reconstruction and measurement of mouse skulls were performed for prenatal and postnatal analysis of the control and ATRA-exposed mice. Results Craniofacial malformations in mouse models caused by ATRA exposure were age dependent. ATRA exposure at E10 induced cleft palate in 81.8% of the fetuses, whereas the palatine bone of E13-exposed mice was intact. Inhibitions of maxilla and mandible development with craniofacial asymmetry induced were observed at E19.5 and P35. Compared with control and E13-exposed mice, the palatine bones of E10-exposed mice were not elevated and were smaller in dimension. Some E10-exposed mice exhibited other craniofacial abnormalities, including premature fusion of mandibular symphysis with a missing mandibular incisor and a smaller mandible. Severe deviated snouts and amorphous craniofacial suture were detected in E13-exposed mice at P35. Conclusion These morphological variations in E10- and E13-exposed mice suggested that ATRA was teratogenic in craniofacial bone development in mice and the effect was age dependent.
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Doroshenko, S. I., O. A. Kaniura, K. V. Storozhenko, S. V. Irkha, D. O. Marchenko, and Kh M. Demianchuk. "PROGNOSIS OF RETENTION AND ABNORMAL POSITION OF CANINES." Ukrainian Dental Almanac, no. 3 (September 23, 2020): 40–47. http://dx.doi.org/10.31718/2409-0255.3.2020.07.

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Canines play an important role in the act of chewing and especially in the aesthetics of the face when you smile. They also serve as a guide to the movements of the mandible “canine management” and they are more resistant to carious lesions. Germination of the canine embryos, unlike other teeth, occurs closer to the base of the jaw, so they erupt later than all front teeth, encountering a number of barriers and, above all, lack of space in the dental arch or its absence in case of early loss of temporary teeth. Given that the canines erupt after the incisors and the first premolars, it is possible to prevent their retention and abnormal eruption in the dental arch. This can be done by timely detection of changes in their main inclination, both to the base of the jaw and relative to the inclination of the erupted teeth, especially lateral incisors, the roots of which serve as a guide axis for canine eruption. The aim of the research was to increase the effectiveness of treatment of retention and abnormal eruption of canines by developing a method for their prediction and timely detection. During the research, 52 patients aged from 7 to 25 years, were divided into four age groups, and they were examined and admitted for orthodontic treatment: I group – 12 patients (23,1%) aged from 7 to 9 years, - with early variable occlusion; II group – 16 patients (30,7%) aged from 10 to 12 years, - at the final stage of variable occlusion; III group – 12 patients (23,1%) aged from 13 to 15 years, - with early permanent occlusion; IV group – 12 patients (23,1%) aged from 16 to 25 years, - with a permanent bite. All patients did not have acute occlusal abnormalities. The following research methods were used during the examination: clinical (presence of abnormal position of the canines in parents and close relatives); anthropometric (measurements on diagnostic models); radiological, mainly orthopantomography (measurement of the axial inclination of the canines relative to the base of the jaw and adjacent teeth) and static research methods. Research in all four groups determined that the inclining of the upper canines to the base of the jaw, averaged on the Maxilla – 86,4° (right side – 86,7°, left side – 86,2° with a difference – 0,5°), and on Mandible – 100,75° (right side – 100,7°, left side – 100,8° with the difference – 0.1°). Axial inclinations of the upper lateral incisors averaged 99,1° (right side – 95,8°, left side – 102,5° with the difference – 6,7°), and lower lateral incisors – 100,65° (right side – 100,7°, left side – 100,8° with the difference – 0,1°). The difference in the inclinations of the canines and lateral incisors on the Maxilla averaged 11,6° (right side – 9,5°, left side – 13,7° with the difference 4,2°) and on the Mandible – 8,9° (right side – 8,6°, left side – 9,3° with the difference – 0.7°). As for these indicators in patients of each of the four age groups, they varied significantly. Conducted research has detected that the most objective indicator in the eruption of abnormal eruption of canines is the significant difference in their inclinations with lateral incisors, which serve as the guiding axis of eruption. In patients from the I group, the difference in inclinations and lateral incisors was on the Maxilla on the right – 9,3°, on the left – 16,0°; and on the Mandible – right side 11,8°, left side 12,2°. In patients from the II group the difference in inclinations and lateral incisors was on the Maxilla on the right side – 13,8°, on the left side – 18,1°; and on the Mandible – right side 7,1°, left side 10,5°, in accordance. In the III group on the Maxilla from the left side – 10,6° and right side – 8,6°; and on the Mandible – 9,6° and 11,1°, in accordance. The difference in inclinations of these teeth was on the Maxilla – right side 4,3°, left side 12,3°; and on the Mandible – 6,0° and 3,3°, in accordance. On this basis, we proposed a method for predicting abnormal eruption of the canines using the constructed “canine triangle” on the orthopantomogram formed by the intersection of the axial inclinations of the canines and lateral incisors (ւВ) with the plane of the base of the jaw, on which the segment (a) is the base of the triangle. The more difference between the inclinations of the canines and lateral incisors ( > 10°), that is the larger the value (ւВ), the longer the size of the base (a) of the triangle, which indicates the difficulty of eruption of the canines in the future (outside the dentition or retention). Timely detection of a significant difference in the inclinations of canines and lateral incisors can prevent abnormal eruption and retention of canines by adjusting their inclinations with lateral incisors and eliminating the lack of space in the early stages of formation of the dental apparatus.
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Dokou, Panagiota, Ioannis K. Karoussis, George Papavasiliou, Phophi Kamposiora, Theophilos P. Vrahopoulos, and John A. Vrotsos. "Osseointegration of Dental Implants in a Patient with Hajdu-cheney Syndrome." Open Dentistry Journal 10, no. 1 (October 31, 2016): 575–86. http://dx.doi.org/10.2174/1874210601610010575.

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Background: Hajdu-Cheney Syndrome (HCS) is a rare hereditary bone metabolism disorder characterized by acro-osteolysis, short stature, craniofacial changes, periodontitis and premature tooth loss. Extensive search of the current literature revealed no reports of implant placement in patients with HCS. Case Report: A 22-year old woman with osteoporosis, generalized advanced chronic periodontitis and premature tooth loss was referred to the Postgraduate Clinic of Periodontology, University of Athens-Greece. The patient was diagnosed in 2001 with HCS. The patient received non-surgical periodontal treatment and several teeth were extracted due to extensive alveolar bone loss. After careful consideration of the possible implications deriving from the patient’s condition and having taken her young age into account, initially, a dental implant was placed in the upper right first premolar region. Specific protocols such as longer healing periods were implemented, so five years after placement and successful osseointegration of this implant, four additional dental implants were placed in the posterior regions of the maxilla and the mandible. Prosthetic rehabilitation followed 6 months after implant placement. Upon completion of periodontal treatment, the patient was enrolled in a periodontal maintenance program. Results: Clinical and radiographic examination of the patient during the periodontal maintenance program after implant placement revealed no abnormalities in the implant region. Conclusion: Patients with HCS suffer from periodontitis, bone destruction and premature tooth loss. This case indicates the successful osseointegration of dental implants in patients with HCS. However, further research is required in order to determine the predictability of dental implant placement in those patients.
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Kusumadewi, An-Nissa, Erna Kurnikasari, Rasmi Rikmasari, and Willyanti Soewondo. "The differences in parallelism between ala-tragus line and occlusal plane of down syndrome and normal individuals." Majalah Kedokteran Gigi Indonesia 5, no. 3 (February 27, 2020): 107. http://dx.doi.org/10.22146/majkedgiind.42488.

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People with down syndrome have a different craniofacial structure compared to normal individuals. Commonly, down syndrome patients have abnormal ear morphology with smaller size, and lower ear position compared to that of normalsubjects. These patients also have smaller nose, shorter maxilla structure and facial height. Other disorders are anomalies in tooth shape, numbers and size. The ala-tragus line is one of the anatomical landmarks to determine the occlusal plane orientation. Abnormalities in the anatomical structure of people with down syndrome can affect the parallelism between the ala-tragus line and the occlusal plane. The purpose of this research was to determine the differences in parallelism between the ala-tragus line and the occlusal plane of people with down syndrome and normal individuals. The sample in this study were people with down syndrome and normal individuals. The sample was photographed using a digital camera with a fox plane attached to the oral cavity. Parallelism of the ala-tragus line and the occlusal plane was analyzed by tracing these photographs. Photo tracing was done using the Autocad 2013 software. The mean value of angle on people with down syndrome (5.852° ± 5.367°) was greater than that of normal individuals (2.169° ± 2.557°). Based on the research, it was concluded that the parallelism of the ala-tragus line to the occlusal plane in people with down syndrome was different from that in normal individuals. The ala-tragus inferior line in normal individuals was more parallel to the occlusal plane compared to that in people with down syndrome.
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Gonchar, M., O. Pomazunovska, O. Logvinova, and A. Kosenko. "RARE CARDIO-RESPIRATORY FINDINGS IN GOLDENHAR SYNDROME (case report)." Inter Collegas 4, no. 4 (December 26, 2017): 188–93. http://dx.doi.org/10.35339/ic.4.4.188-193.

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The Goldenhar Syndrome is the rare congenital abnormalities that include Facio-Auriculo-Vertebral Spectrum, First and Second Branchial Arch Syndrome, Oculo-Auriculo-Vertebral Spectrum, oculo-auriculo-vertebral disorder. Oculo-auriculo-vertebral disorder (OAVD) represents the mildest form of the disorder, while Goldenhar syndrome presents frequently as the most severe form. Hemifacial microstomia appears to be an intermediate form. Goldenhar Syndrome includes patients with facial asymmetry to very severe facial defects (resulting from unilateral facial skeleton hypoplasia) with abnormalities of skeleton and/or internal organs. The most significant are epibulbar dermoids, dacryocystitis, auricular abnormalities, preauricular appendages, preauricular fistulas and hypoplasia of the malar bones, mandible, maxilla and zygomatic arch. Some patients are found to have oculo-auriculo-vertebral disorder, namely low height, delayed psychomotor development, retardation (more frequently seen with cerebral developmental anomalies and microphthalmia), speech disorders (articulation disorders, rhinolalia, different voice disorders, unusual timbre), psycho-social problems, autistic behaviors. The authors describe the clinical case of Goldenhar Syndrome in boy a 3-months-year-old. This case demonstrates a rarely described association of oculo-auriculo-vertebral disorders, malformation of respiratory system (hypoplasia of the lower lobe of the left lung with relaxation of the left cupula of the diaphragm), heart abnormality (atrium septa defect).Key words: Goldenhar Syndrome, children, diagnostic РІДКІСНІ КАРДІОРЕСПІРАТОРНІ ЗНАХІДКИ ПРИ СИНДРОМІ ГОЛДЕНХАРА.Гончар М.О., Помазуновська О.П., Логвінова О.Л., Тригуб Ю.В., Косенко А.М.Синдром Гольденхара є рідкісною вродженою аномалією, яка включає перший і другий синдром Бінья, окуло-аурикуло-вертебральний спектр, окуло-аурикуло-хребетний синдром. Окуло-аурикула-хребетний синдром є самою м'якою формою розладу, тоді як синдром Гольденхара часто протікає важко. Хеміфаціальная мікростомія - проміжна форма. Синдром Гольденхара включає як пацієнтів з лицьової асиметрією так і з дуже важкими дефектами лицьового черепа (в результаті односторонньої гіпоплазії лицьового скелета) з відхиленнями в будові скелета і / або внутрішніх органів. Найбільш значущими є епібульбарной дермоіди, дакріоцистит, аурікулярні аномалії, предорікулярні придатки, предорікулярні фістули, гіпоплазію нижньої щелепи, верхньої щелепи і щелепної дуги. У деяких пацієнтів виявляється окуло-аурикуло-хребетний синдром, а саме низькорослість, уповільнене психомоторне розвиток, аномалії розвитку мозку і мікрофтальмії, розлад мови, порушення артикуляції, алалия, різні порушення мови, незвичайний тембр голосу і психосоціальні порушення, аутизм. Автори описують клінічний випадок синдрому Гольденхара у хлопчика 3-місячного віку. Цей випадок демонструє асоціацію окуло-аурикула-хребетних розладів які рідко зустрічаються в практиці, мальформацию дихальної системи (гіпоплазію нижньої частки лівої легені з релаксацією лівого купола діафрагми), аномалію серця (дефект міжпредсердної перегородки).Ключові слова: синдром Гольденхара, діти, діагностика РЕДКИЕ КАРДИОРЕСПИРАТОРНЫЕ НАХОДКИ ПРИ СИНДРОМЕ ГОЛДЕНХАРА.Гончарь М.А., Помазуновская Е.П., Логвинова О.Л., Тригуб Ю.В., Косенко А.М.Синдром Голденхара представляет собой редкие врожденные аномалии, которые включают первый и второй синдром Биньяла, окуло-аурикуло-вертебральный спектр, окуло-аурикуло-позвоночный синдром. Окуло-аурикуло-позвоночный синдром (OAVD) представляет собой самую мягкую форму расстройства, тогда как синдром Голденхара часто протекает тяжело. Хемифациальная микростомия представляется промежуточной формой. Синдром Голденхара включает как пациентов с лицевой асимметрией так и с очень тяжелыми дефектами лицевого черепа (в результате односторонней гипоплазии лицевого скелета) с отклонениями в строении скелета и / или внутренних органов. Наиболее значимыми являются эпибульбарные дермоиды, дакриоцистит, аурикулярные аномалии, предорикулярные придатки, предорикулярные фистулы, гипоплазия скуловых костей, нижней челюсти, верхней челюсти и скуловой дуги. У некоторых пациентов выявляется окуло-аурикуло-позвоночный синдром, а именно низкорослость, замедленное психомоторное развитие, аномалии развития мозга и микрофтальмии, расстройство речи, нарушения артикуляции, ринолалия, различные нарушения речи, необычный тембр голоса и психосоциальные нарушения, аутизм. Авторы описывают клинический случай синдрома Голденхара у мальчика 3-месячного возраста. Этот случай демонстрирует редко встречаемую ассоциацию окуло-аурикуло-позвоночных расстройств, мальформацию дыхательной системы (гипоплазию нижней доли левого легкого с релаксацией левого купола диафрагмы), аномалию сердца (дефект перегородки атриума).Ключевые слова: синдром Голденхара, дети, диагностика
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39

Alexandrov, A. A., A. V. Starokha, A. V. Davydov, and V. F. Votyakov. "Application of wave-current sinusoscopy in algorithm of diagnostic and treatment of odontogenic maxillary sinusitis." Bulletin of Siberian Medicine 10, no. 1 (February 28, 2011): 137–42. http://dx.doi.org/10.20538/1682-0363-2011-1-137-142.

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The aim and task of the study were to improve the method of wave-current sinusoscopy and to develop the algorithm of compex treatment of acute odontogenic maxillary sinusitis with concomitant pathology of intranasal structures abnormalities. 106 patients with acute and chronic odontogenic maxillary sinusitis were examined. The improved method of wave-current sinusoscopy allows with high level of significance to diagnose in the maxillary sinus not only exudates and side-wall hyperplasia, but artificial bodies — according to the value of wave-current sinusoscopy equal to (247 ± 74) Hz. Including this method to the treatmentdiagnostic algorithm helps to improve treatment of the patients with odontogenic maxillar sinusitis.
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40

Kim, Soung Min, Young Joon Lee, Sang Shin Lee, Yeon Sook Kim, Suk Keun Lee, Il Bong Kim, and Je Geun Chi. "Abnormal Maxillary Trapezoid Pattern in Human Fetal Cleft Lip and Palate." Cleft Palate-Craniofacial Journal 45, no. 2 (March 2008): 131–40. http://dx.doi.org/10.1597/06-077.1.

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Objective: To elucidate abnormal growth patterns of human fetal maxillae with cleft lip and palate (CLP). Subject: A total of 71 fetal maxillae with CLP were obtained from aborted human fetuses. Method: Dimensions of the maxillary trapezoid (MT), formed by the maxillary primary growth centers (MxPGC), were taken from radiographic images. The CLP dimensions were compared with maxillary trapezoid dimensions of normal fetuses from a previous study (Lee et al., 1992). Main Outcome Measures: Cleft lip subjects without a cleft palate, unilateral cleft lip-alveolar cleft or cleft palate (UCL+A/UCLP), and bilateral cleft lip-alveolar cleft or cleft palate (BCL+A/BCLP) displayed abnormal MT patterns. MT abnormalities were most marked in the BCL+A/BCLP cohort. Results: The MT growth of prenatal CLP maxillae was severely arrested, resulting in abnormal MT shape on palatal radiograms. BCL+A/BCLP subjects had a more protruded nasal septum than subjects with other types of CLPs, while UCL+A/UCLP subjects showed severe deviation of the protruded nasal septum toward the noncleft side. Cleft lip-only subjects also exhibited abnormal MT growth. Conclusion: MT is primarily involved in CLPs, so that the MT shape could be utilized as a sensitive indicator for the analysis of maxillary malformation in different types of CLPs.
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41

Wittkopf, Maria, and Steven L. Goudy. "Fgf8 is Necessary for Normal Frontonasal Development." Otolaryngology–Head and Neck Surgery 139, no. 2_suppl (August 2008): P105. http://dx.doi.org/10.1016/j.otohns.2008.05.535.

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Problem Craniofacial development is a complex process. We explore the role of ectodermal Fgf8 during craniofacial development in mice. Fgf8 is a multi-functional growth factor known to induce cell migration and differentiation. We hypothesize that Fgf8 is necessary for frontonasal development. To determine its role, we selectively removed Fgf8 signaling in cells expressing the AP2 gene. Methods We generated AP2 Cre Fgf8 f/f R26R mice at e13–18. The embryos are harvested and fixed. They are dehydrated or saturated in 30% sucrose, then embedded in paraffin or OCT compound, respectively, for sectioning. The paraffin sections are used for morphologic examination following H&E and PAS staining. The cryosections are used for X-gal staining and immunofluorescence. Skeletal preparations are used to assess the craniofacial skeleton. Results AP2 Cre mice are examined identifying AP2 expression in the developing epithelium. Gross examination of the AP2 Cre Fgf8 f/f mice reveals severe mid-face shortening and micrognathia. These mice are nonviable due to their severe facial abnormalities. Close inspection reveals prominent eyes that appear normally formed but lack eyelids. The skeletal preparation of the AP2 Cre Fgf8 f/f mouse demonstrates almost absent mandibular development and hypoplastic maxilla. This correlates with the hypoplastic, ill-organized sinus cavities with lack of nasal septum development seen on histologic sections. Examination of the epithelium and oral mucosa of these mutant mice demonstrates a verrucous morphology with poor differentiation. Conclusion Fgf8 expression in the ectoderm appears to be necessary for frontonasal development in mice. Without epithelial Fgf8 expression, the craniofacial and epidermal development is severely affected. Future studies will further characterize the epithelial and mesenchymal phenotype of the AP2 Cre Fgf8 f/f mutant mice. Significance The Fibroblast Growth Factor (Fgf) family is involved in multiple steps of craniofacial formation. Further studies elucidating the specific roles of its members, including Fgf8, will help better understand and manage craniofacial malformations.
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42

Villotte, S., A. R. Ogden, and E. Trinkaus. "Dental Abnormalities and Oral Pathology of the Pataud 1 Upper Paleolithic Human." Bulletins et Mémoires de la Société d'Anthropologie de Paris 30, no. 3-4 (September 18, 2018): 153–61. http://dx.doi.org/10.3166/bmsap-2018-0020.

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We have re-evaluated the dental abnormalities and oral pathology evident on the Mid-Upper Paleolithic Pataud 1 skeleton, including additional remains recently excavated for this individual, in an effort to expand current knowledge of Pleistocene human paleopathology, in light of current clinical and paleopathological assessments of oral variation and diseases. The young adult female Pataud 1 presents an impacted right M3, widespread periodontitis, large retromolar voids, double right maxillary supernumerary (paramolar) teeth, and new bone deposition on the medial mandibular rami and posterior maxillae. The Pataud 1 remains thus join a substantial sample of Pleistocene humans with congenital/developmental abnormalities, some of which (as in Pataud 1) consequently resulted in secondary abnormalities. M3impaction and supernumerary teeth are known in a couple of other Mid-Upper Paleolithic individuals, and mild to moderate periodontal disease appears to have been widespread. However, such marked resorption of the alveolar margin in a young adult is unusual, and the secondary inflammation (possibly septicemia) leading to new bone deposition is otherwise unknown in the sample and may have led to her death.
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43

Singh, Jasjit, Kathleen O’Donnell, Negar Ashouri, Felice C. Adler-Shohet, Delma Nieves, M. Tuan Tran, Antonio Arrieta, Lisa Tran, Michele Cheung, and Matthew Zahn. "926. Outbreak of Invasive Nontuberculous Mycobacterium (NTM) Infections Associated With a Pediatric Dental Practice." Open Forum Infectious Diseases 5, suppl_1 (November 2018): S29. http://dx.doi.org/10.1093/ofid/ofy209.067.

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Abstract Background In 2016, an Orange County, California, pediatric dental clinic’s contaminated water system led to the largest outbreak of odontogenic NTM infections yet described. Methods Mandatory reporting and active case finding directed by County Public Health were conducted in collaboration with community Pediatric Infectious Disease physicians for patients who underwent pulpotomy at Dental Clinic A from January 1 to September 6, 2016. Confirmed cases were those with positive NTM culture. Probable cases were those with multiple pulmonary nodules on computed tomography (CT), necrotic bone or osteomyelitis seen at surgery, or pathology with positive acid-fast bacilli stain, granulomatous inflammation or chronic osteomyelitis. Clinical data was collected from medical records. Results Of 1,089 patients at risk, 71 cases (22 (31%) confirmed and 49 (69%) probable) (Figure 1) had been identified as of March 19, 2018 (Figure 2). Median case age was 6 years (range 2–11 years). Symptoms began a median of 85 days (range 1–409 days) after pulpotomy (Figure 3). Pain and/or swelling on admission were reported in 79%; 21% were asymptomatic. CT findings included 49/70 with abnormalities of the mandible or maxilla, 13/70 with lymphadenopathy, and 19/68 with pulmonary nodules. Only 6/60 had erythrocyte sedimentation rate &gt;40 mm/hour. Of 71 cases, 70 were hospitalized and underwent surgical debridement, for an average of 8.5 inpatient days (range 1–60 days); 23 had &gt;1 hospitalization and 26 required &gt;1 inpatient surgery. Permanent teeth were lost in 45/65 (range of 1–6 teeth lost). Intravenous antibiotics were administered to 32 cases for a median length of 137 days (range 113–282 days). Clofazimine was obtained for 29/32 cases as part of the regimen. Medical therapy was complicated by peripherally inserted central catheter malfunction/replacement/infection (18/27), rash (2/27), neutropenia (12/27), and elevated creatinine (7/27). All treated children showed evidence of jaw healing with resolved or improving lung nodules at 1-year follow-up. Conclusion This is the largest outbreak of invasive NTM infections seen associated with a pediatric dental practice. While infections were indolent, patients suffered medical and surgical consequences of treatment. Enhanced national dental water quality standards are needed to prevent future outbreaks. Disclosures A. Arrieta, Melinta Therapeutics: Investigator, Research support
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44

Bittegeko, SB, J. Arnbjerg, R. Nkya, and A. Tevik. "Multiple dental developmental abnormalities following canine distemper infection." Journal of the American Animal Hospital Association 31, no. 1 (January 1, 1995): 42–45. http://dx.doi.org/10.5326/15473317-31-1-42.

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Multiple dental developmental abnormalities (e.g., dental impaction, partial eruption, oligodontia, enamel hypoplasia, and dentin hypoplasia) in a 10-month-old, female, Tanzanian tropical mixed-breed puppy are reported. Various permanent teeth were involved. These included impacted mandibular canine and first and third premolar teeth; a partially erupted maxillary canine tooth; oligodontia of a mandibular fourth premolar tooth; enamel hypoplasia of the maxillary and mandibular canine teeth, incisors, and premolars; and dentin hypoplasia of the maxillary incisors, maxillary premolars, and mandibular premolars. The puppy had clinical canine distemper at the age of two months and had no history of any other systemic nor generalized infection prior to the time when the dental abnormalities were observed.
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45

Kamel, R. H. "Nasal endoscopy in chronic maxillary sinusitis." Journal of Laryngology & Otology 103, no. 3 (March 1989): 275–78. http://dx.doi.org/10.1017/s0022215100108692.

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AbstractThe role of the anterior ethmoids in the pathogenesis of chronic maxillary sinusitis is still a subject of controversy. Although the symptoms of maxillary sinusitis may be clinically dominant, many previous studies have showed that the origin of this disease was, in most cases, located within the anterior ethmoid region.This study included 100 Egyptian patients, suffering from chronic maxillary sinusitis (confirmed by maxillary sinoscopy), who were subjected to ‘systematic nasal endoscopy’. It was found that all cases of chronic maxillary sinusitis were associated with anatomical variations and/or pathological abnormalities of ‘the ostiomeatal area’. It is recommended, therefore, that during the diagnosis and treatment of chronic maxillary sinusitis, attention should be given to the region of the middle meatus and anterior ethmoid complex (or ‘ostiomeatal area’) for any anatomical variations and/or pathological abnormalities in order to avoid recurrence of maxillary sinusitis. This is the basis of the procedure of functional endoscopic sinus surgery.
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46

Abrahams, J. J., and R. M. Glassberg. "Dental disease: a frequently unrecognized cause of maxillary sinus abnormalities?" American Journal of Roentgenology 166, no. 5 (May 1996): 1219–23. http://dx.doi.org/10.2214/ajr.166.5.8615273.

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47

KONUMA, Takayuki, Eiichi SAKAMOTO, Yasuhiko HIRANUMA, Jun SHIMADA, Tatsuya KAMEYAMA, Yoshiro YAMAMOTO, Hosaku SUMIDA, et al. "7 cases of postoperative maxillary cysts accompanied by ocular abnormalities." Japanese Journal of Oral & Maxillofacial Surgery 35, no. 2 (1989): 496–502. http://dx.doi.org/10.5794/jjoms.35.496.

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48

Spolaor, Fabiola, Martina Mason, Francesco Cocilovo, Claudio Cobelli, Antonio Gracco, and Zimi Sawacha. "Emg abnormalities in children with maxillary transverse discrepancy and crossbite." Gait & Posture 42 (September 2015): S16. http://dx.doi.org/10.1016/j.gaitpost.2015.07.038.

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49

Hanna, Ehab, Howard L. Levine, Sanford Timen, and Bernard Kotton. "Hypoplasia of the Maxillary Antrum: Anatomic Abnormalities, Diagnostic Difficulties and Surgical Implications." American Journal of Rhinology 7, no. 3 (May 1993): 105–10. http://dx.doi.org/10.2500/105065893781976384.

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Using conventional radiography, maxillary sinus hypoplasia (MSH) may be misdiagnosed as chronic infective sinusitis in patients with chronic nasal symptoms. Commonly associated anatomical abnormalities of the lateral nasal wall and orbit may also be missed. Failure to recognize these abnormalities is fraught with hazards should sinus surgery be contemplated on such patients. With the use of high resolution computed tomography scans and rigid nasal endoscopy, MSH and associated subtle anatomic abnormalities of related structures are diagnosed with higher precision and surgical complications minimized. The incidence, pathogenesis, and classification of MSH is reviewed. The clinical and surgical implications of associated anomalies of the lateral nasal wall are discussed. Two illustrative cases are presented.
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50

Golovcencu, Loredana, Cristian Romanec, Maria Alexandra Martu, Daniela Anistoroaiei, and Mariana Pacurar. "Particularities of Orthodontic Treatment in Patients with Dental Anomalies that Need Orthodontic - Restorative Therapeutic Approach." Revista de Chimie 70, no. 8 (September 15, 2019): 3046–49. http://dx.doi.org/10.37358/rc.19.8.7484.

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Orthodontics is a specialty of dental medicine that discovers and treat dento - maxillary abnormalities (or lack of teeth alignment - malocclusions - unsightly dental rotation, lack of congruence of the two dental arches) solving both aesthetic and functional problems ;contributes to improving dental and facial aesthetics, and implicitly to improving psychological well-being, self-esteem and quality of life. Orthodontic treatment is a support for multidisciplinary approach with other dental specialties in order to obtain facial and dental aesthetics; seeks to improve the appearance of smile and occlusion (bite) so that the teeth can bear without trauma the daily forces sore from the time of mastication; has the potential to eliminate future dental problems, including abnormal teeth wear. Dento-maxillary abnormalities synthesize current concepts of normal occlusion and explain the mechanisms by which dento-maxillary abnormalities occur, the morphological differences that allow classification and how they can affect the individual�s appearance. The study includes a wider group of pediatric patients aged between 7 and 11 years, growing showing a diverse pathology, periodontal dental trauma, dental abnormalities, which may require the prosthesis. It can be argued that in most chromosomal syndromes, oro-facial abnormalities are major symptoms as pathognomonic value for clinical diagnosis; involvement of other body regions in these syndromes are frequently nonspecific and common to several syndromes.The great variability of their treatment measures used in dental abnormalities requires knowledge of their causal factors, as well as their mechanism of action and production.
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