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Journal articles on the topic 'Maze probe'

Author: Grafiati

Published: 4 June 2021

Last updated: 8 February 2022

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1

Weimar, Timo, Anson M. Lee, Shuddhadeb Ray, Richard B. Schuessler, and Ralph J. Damiano. "Evaluation of a Novel Cryoablation System: In vivo Testing in a Chronic Porcine Model." Innovations: Technology and Techniques in Cardiothoracic and Vascular Surgery 7, no. 6 (2012): 410–16. http://dx.doi.org/10.1177/155698451200700607.

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Objective Cryoablation is commonly used at present in the surgical treatment of atrial fibrillation (AF). However, there have been few studies examining the efficacy of the commonly used ablation devices. This report compares the efficacy of two cryoprobes in creating transmural endocardial lesions on the beating heart in a porcine model for chronic AF. Methods In six Hanford miniature swine, the right atrial appendage and the inferior vena cava were isolated using a bipolar radiofrequency clamp to create areas of known conduction block. A connecting ablation line was performed endocardially v

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Weimar, Timo, Anson M. Lee, Shuddhadeb Ray, Richard B. Schuessler, and Ralph J. Damiano. "Evaluation of a Novel Cryoablation System: In vitro Testing of Heat Capacity and Freezing Temperatures." Innovations: Technology and Techniques in Cardiothoracic and Vascular Surgery 7, no. 6 (2012): 403–9. http://dx.doi.org/10.1177/155698451200700606.

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Objective Cryoablation has been used to ablate cardiac tissue for decades and has been shown to be able to replace incisions in the surgical treatment of atrial fibrillation. This in vitro study evaluates the performance of a novel cryoprobe and compares it with existing commercially available devices. Methods A new malleable 10-cm aluminum cryoprobe was compared with a rigid 3.5-cm copper linear probe using in vitro testing to evaluate performances under different thermal loads and with different tissue thicknesses. Radial dimensions of ice formation were measured in each water bath by a high

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Altin, Firat H., Sevket Balli, Murat Cicek, et al. "Early outcomes of usage of cryoFORM® probe for cryomaze procedure in congenital heart surgery." Cardiology in the Young 30, no. 12 (2020): 1874–79. http://dx.doi.org/10.1017/s1047951120003029.

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AbstractObjectives:This study aimed to evaluate the early outcomes of patients who underwent a concomitant therapeutic maze procedure for congenital heart surgery.Materials and Methods:Between 2019 and 2020, eight patients underwent surgical cryoablation by using the same type of cryoablation probe.Results:Three patients had atrial flutter, two had Wolf–Parkinson–White syndrome, two intra-atrial reentrant tachycardia, and one had atrial fibrillation. Four patients underwent electrophysiological study. Preoperatively, one patient was on 3, two were on 2, five were on 1 antiarrhythmic drug. Six

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Mohapatra, Srikant, Vijaykumar Muppiri, Sumit Narang, Kaushik Mukherjee, and Amit Banerjee. "An ‘extended’ probe to facilitate electrocautery maze lesions along with mitral valve surgery." Indian Journal of Thoracic and Cardiovascular Surgery 24, no. 2 (2008): 156. http://dx.doi.org/10.1007/s12055-008-0027-z.

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Liu, Xiaotong, Dong Hyun Kim, Jong Min Kim, et al. "The Memory-Ameliorating Effects of Artemisia princeps var. orientalis Against Cholinergic Dysfunction in Mice." American Journal of Chinese Medicine 40, no. 05 (2012): 993–1005. http://dx.doi.org/10.1142/s0192415x12500735.

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Artemisia princeps var. orientalis (Compositae) is widely distributed in China, Japan and Korea and is known to have anti-inflammatory and anti-oxidative activities. The ethyl acetate fraction of ethanolic extract of A. princeps var. orientalis (AEA) was found to inhibit acetylcholinesterase activity in a dose-dependent manner in vitro (IC50 value: 541.4 ± 67.5 μg/ml). Therefore, we investigated the effects of AEA on scopolamine-induced learning and memory impairment using the passive avoidance, the Y-maze, and the Morris water maze tasks in mice. AEA (100 or 200 mg/kg, p.o.) significantly ame

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Shaimi, Asma Ulhusna, Hasmah Abdullah, Zalina Ismail, and Wan Amir Nizam Wan Ahmad. "Effect of Dehydroepiandrosterone Sulfate on the Modulation of Memory and Learning in Sprague-Dawley Rat Hippocampus." Proceeding International Conference on Science and Engineering 2 (March 1, 2019): 291–95. http://dx.doi.org/10.14421/icse.v2.105.

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Dehydroepiandrosterone sulphate (DHEAS) is a neurosteroid that is found in greater concentration within the brain rather than in any other body organ (Corpechot et al., 1981) and studies have shown that in the brain, DHEAS has a role in enhancing both learning and memory (Markowski et.al., 2001). This present study investigated the relationship between DHEAS and spatial learning and memory in the rat hippocampus. Male Sprague-Dawley rats were divided into two groups and their spatial learning behaviour was evaluated with the Morris Water Maze. The intensity of DHEAS was simultaneously recorded

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Vittalrao, Amberkar Mohanbabu, Abhishek Chakraborti, Meena Kumari K, Nandit Banawalikar, and Kiran Kumar N. "Evaluation of Vigilance Promoting Drugs Modafinil and Caffeine on Cognition Enhancing Activities in Wistar Albino Rats-A Comparative Study." Biomedical & Pharmacology Journal 12, no. 3 (2019): 1463–70. http://dx.doi.org/10.13005/bpj/1776.

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Learning process can’t be made simple unless one is wakeful/attentive/aware of present situations. Worldwide, it is known fact that behavioral modulating actions of Caffeine is used in many common beverages, likewise modafinil appears to promote a possible facilitatory effect on cognitive function perhaps that is the primary reason why is it is been used in narcolepsy, obstructive sleep apnea, shiftwork and Jet lag syndrome. The rationale for conducting this animal experiment was to exploit/evaluate the vigilance promoting pharmacological actions of modafinil and compare with caffeine and riva

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Menard, Janet, and Dallas Treit. "Lateral and medial septal lesions reduce anxiety in the plus-maze and probe-burying tests." Physiology & Behavior 60, no. 3 (1996): 845–53. http://dx.doi.org/10.1016/0031-9384(96)00138-2.

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Degroot, Aldemar, Shauna Kashluba, and Dallas Treit. "Septal GABAergic and hippocampal cholinergic systems modulate anxiety in the plus-maze and shock-probe tests." Pharmacology Biochemistry and Behavior 69, no. 3-4 (2001): 391–99. http://dx.doi.org/10.1016/s0091-3057(01)00541-x.

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Degroot, Aldemar, and Dallas Treit. "Dorsal and ventral hippocampal cholinergic systems modulate anxiety in the plus-maze and shock-probe tests." Brain Research 949, no. 1-2 (2002): 60–70. http://dx.doi.org/10.1016/s0006-8993(02)02965-7.

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Treit, Dallas, Aldemar Degroot, Shauna kashluba, and Gerd D. Bartoszyk. "Systemic EMD 68843 injections reduce anxiety in the shock-probe, but not the plus-maze test." European Journal of Pharmacology 414, no. 2-3 (2001): 245–48. http://dx.doi.org/10.1016/s0014-2999(01)00799-3.

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Markowska, Alicja L., Jeffrey M. Long, Christopher T. Johnson, and David S. Olton. "Variable-interval probe test as a tool for repeated measurements of spatial memory in the water maze." Behavioral Neuroscience 107, no. 4 (1993): 627–32. http://dx.doi.org/10.1037/0735-7044.107.4.627.

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Treit, Dallas, Angela Robinson, Susan Rotzinger, and Christine Pesold. "Anxiolytic effects of serotonergic interventions in the shock-probe burying test and the elevated plus-maze test." Behavioural Brain Research 54, no. 1 (1993): 23–34. http://dx.doi.org/10.1016/0166-4328(93)90045-r.

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Cong, Wei-hong, Bin Yang, Li Xu та ін. "Herbal Extracts Combination (WNK) Prevents Decline in Spatial Learning and Memory in APP/PS1 Mice through Improvement of Hippocampal AβPlaque Formation, Histopathology, and Ultrastructure". Evidence-Based Complementary and Alternative Medicine 2012 (2012): 1–9. http://dx.doi.org/10.1155/2012/478190.

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To investigate the cognitive enhancement effect of WNK, an extracts combination ofP. ginseng, G. biloba, andC. sativusL. and possible mechanisms, 5-month-old APP/PS1 transgenic mice were used in this study. After 3 months of administration, all mice received Morris water maze (MWM) training and a probe test. Mouse brain sections were detected by immunohistochemistry, HE staining, and transmission electron microscopy. MWM results showed significant difference between transgenic mice and nontransgenic littermates (P<0.05,P<0.01). WNK-treated mice exhibited enhanced maze performance over th

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McElroy, Taylor, Taurean Brown, Fred Kiffer, et al. "Assessing the Effects of Redox Modifier MnTnBuOE-2-PyP 5+ on Cognition and Hippocampal Physiology Following Doxorubicin, Cyclophosphamide, and Paclitaxel Treatment." International Journal of Molecular Sciences 21, no. 5 (2020): 1867. http://dx.doi.org/10.3390/ijms21051867.

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Background: Chemotherapy treatment for breast cancer can induce cognitive impairments often involving oxidative stress. The brain, as a whole, is susceptible to oxidative stress due to its high-energy requirements, limited anaerobic respiration capacities, and limited antioxidant defenses. The goal of the current study was to determine if the manganese porphyrin superoxide dismutase mimetic MnTnBuOE-2-PyP (MnBuOE) could ameliorate the effects of doxorubicin, cyclophosphamide, and paclitaxel (AC-T) on mature dendrite morphology and cognitive function. Methods: Four-month-old female C57BL/6 mice

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Ramakrishna, Kakarla, Krishnamoorthy Srinivasan, and Shyam Sunder Sharma. "Chronic treatment of 4-phenylbutyric acid ameliorates cognitive impairment after focal cerebral ischemia/ reperfusion injury in rats." Indian Journal of Physiology and Pharmacology 64 (January 12, 2021): 188–94. http://dx.doi.org/10.25259/ijpp_172_2020.

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Objectives: Stroke, apart from causing physical disabilities, it also often leads to cognitive impairment in patients. At present, there is no effective drug available for the treatment of post-stroke cognitive impairment. The present study was undertaken to evaluate the ameliorative effect of 4-Phenylbutyric acid (PBA) against cognitive and memory deficits due to focal cerebral ischemia/reperfusion (I/R) in rats. Materials and Methods: Focal cerebral I/R injury was achieved by the middle cerebral artery occlusion (MCAO) method. PBA (100 and 300 mg/kg, i.p.) was administered once daily for 2 w

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Gibula-Tarlowska, Ewa, Karolina Wydra та Jolanta H. Kotlinska. "Deleterious Effects of Ethanol, Δ(9)-Tetrahydrocannabinol (THC), and Their Combination on the Spatial Memory and Cognitive Flexibility in Adolescent and Adult Male Rats in the Barnes Maze Task". Pharmaceutics 12, № 7 (2020): 654. http://dx.doi.org/10.3390/pharmaceutics12070654.

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Research demonstrates that adolescents differ from adults in their response to drugs of abuse. The aim of the present study was to examine the influence of ethanol, Δ9-tetrahydrocannabinol hydrochloride (THC), and a combination of these drugs given during adolescence on spatial memory in adolescent and adult rats. Thus, adolescent rats (postnatal day (PND) 30) were subjected to the following groups: 0.9% NaCl; 1.5 g/kg ethanol; 1.0 mg/kg THC; 1.5 g/kg ethanol + 1.0 mg/kg THC. Rats received drug injection four times at three-day intervals. One day after the last injection, half of the treated a

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Yang, Y., J. Cao, W. Xiong, et al. "Both stress experience and age determine the impairment or enhancement effect of stress on spatial memory retrieval." Journal of Endocrinology 178, no. 1 (2003): 45–54. http://dx.doi.org/10.1677/joe.0.1780045.

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It has been documented that stress or glucocorticoids have conflicting effects on memory under different conditions. However, it is not fully understood why stress can either impair or enhance memory. Here, we have examined the performance of six age groups of Wistar rats in a water maze spatial task to evaluate the effects of stress under different conditions. We found that the impairment or enhancement effect of an 'elevated platform' (EP) stress on memory was dependent on previous stress experience and on age. EP stress impaired memory retrieval in water maze naive animals, but enhanced rat

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Hodosy, Julius, Daniela Ostatnikova, Vladimír Riljak, Jaromir Myslivecek, and Peter Celec. "The effect of rapid and depot testosterone and estradiol on spatial performance in water maze." Open Life Sciences 7, no. 4 (2012): 596–602. http://dx.doi.org/10.2478/s11535-012-0046-z.

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AbstractMen and women differ in some cognitive functions including spatial abilities. These differences seem to be affected by sex steroids, but the results are controversial. The aim of this work is to describe the effects of rapid or depot testosterone and estradiol on spatial memory in rats. Thirty-two adult male Wistar rats were divided into 6 groups. Five groups were gonadectomized, and one group was left as control. Castrated groups received sterile oil, testosterone isobutyras, testosterone propionate, estradiol dipropionate or estradiol benzoate. We evaluated spatial performance (escap

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Chen, Long, Xiaobo Yang, Xiaoyong Zhou, et al. "Hyperactivity and impaired attention in Gamma aminobutyric acid transporter subtype 1 gene knockout mice." Acta Neuropsychiatrica 27, no. 6 (2015): 368–74. http://dx.doi.org/10.1017/neu.2015.37.

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ObjectivesAttention-deficit hyperactivity disorder (ADHD) is a common neurobehavioural disorder. It is conceivable that Gamma aminobutyric acid (GABA) neurotransmission is implicated in the pathophysiology of ADHD. This study investigated the effect of GABA transporter 1 (GAT-1) on the anxiety-like behaviours and cognitive function in knockout mice.MethodsIn all, 20 adult male mice were divided into two groups: wild-type (WT) group and GAT-1−/− group. The open field test, elevated O-maze (EZM) and Morris water maze were used to evaluate behavioural traits relevant to ADHD.ResultsCompared with

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Zhou, Zan, Jun Li Chang, Min Xie, and Xiao Mei Liao. "Effects of Vision Clues on Spatial Cognition of Mice." Advanced Materials Research 429 (January 2012): 303–7. http://dx.doi.org/10.4028/www.scientific.net/amr.429.303.

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To investigate the effect of vision clues on spatial cognitive ability of mice, 20 healthy Mus musculus (Km) mice were divided into two groups, control group and test group. During the experiment, the control group was trained in the Morris water maze with the visual signals while all the visual reference objects of Morris water maze were removed when the test group was trained. The latencies and swimming paths of the two groups were recorded for comparing the effect of vision clues on spatial cognitive ability of the mice. The results showed that there was no significant difference of swimmin

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Kempermann, G., and F. H. Gage. "Genetic determinants of adult hippocampal neurogenesis correlate with acquisition, but not probe trial performance, in the water maze task." European Journal of Neuroscience 16, no. 1 (2002): 129–36. http://dx.doi.org/10.1046/j.1460-9568.2002.02042.x.

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Pesold, Christine, and Dallas Treit. "Excitotoxic lesions of the septum produce anxiolytic effects in the elevated plus-maze and the shock-probe burying tests." Physiology & Behavior 52, no. 1 (1992): 37–47. http://dx.doi.org/10.1016/0031-9384(92)90431-z.

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Czajkowski, Rafał, Bartosz Zglinicki, Emilia Rejmak, and Witold Konopka. "Strategy-Specific Patterns of Arc Expression in the Retrosplenial Cortex and Hippocampus during T-Maze Learning in Rats." Brain Sciences 10, no. 11 (2020): 854. http://dx.doi.org/10.3390/brainsci10110854.

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The retrosplenial cortex (RSC) belongs to the spatial memory circuit, but the precise timeline of its involvement and the relation to hippocampal activation have not been sufficiently described. We trained rats in a modified version of the T maze with transparent walls and distant visual cues to induce the formation of allocentric spatial memory. We used two distinct salient contexts associated with opposite sequences of turns. Switching between contexts allowed us to test the ability of animals to utilize spatial information. We then applied a CatFISH approach with a probe directed against th

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Kim, Ji Hyun, Dae-Hyun Hahm, Hye-Jung Lee, Kwang Ho Pyun, and Insop Shim. "Acori graminei rhizomaAmeliorated Ibotenic Acid-Induced Amnesia in Rats." Evidence-Based Complementary and Alternative Medicine 6, no. 4 (2009): 457–64. http://dx.doi.org/10.1093/ecam/nem158.

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In the present study, we investigated the effects ofAcori graminei rhizoma(AGR) on learning and memory for the Morris water maze task and on the central cholinergic system of the rats with excitotoxic medial septum (MS) lesion. On the water maze test, the rats were trained to find a platform that was in a fixed position during 6 days and then they received a 60 s probe trial in which the platform was removed from the pool on the 7th day. Ibotenic lesioning of the MS impaired the performance on the maze test and it caused degeneration of choline acetyltransferase and acetylcholine esterase in t

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Venkataramaiah, Ch, G. Swathi, and W. Rajendra. "MORRIS WATER MAZE – A BENCH MARK TEST FOR LEARNING AND MEMORY DISORDERS IN ANIMAL MODELS: A REVIEW." Asian Journal of Pharmaceutical and Clinical Research 11, no. 5 (2018): 25. http://dx.doi.org/10.22159/ajpcr.2018.v11i5.24292.

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The morris water maze (MWM) was developed by morris as a device to investigate spatial learning and memory in laboratory rats. MWM has become one of the most frequently used laboratory tools in behavioral neuroscience. The MWM task has been often used in the validation of rodent models for neurocognitive disorders (e.g., Parkinson, Alzheimer, Epilepsy, and Schizophrenia), and the evaluation of possible neurocognitive treatments. It is also being used to assess the properties of established potential antipsychotics in animal models of Schizophrenia. The MWM task requires rats to find a hidden p

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Abdel-Zaher, Ahmed O., Mostafa M. Hamdy, Mahran S. Abdel-Rahman, and Doaa H. Abd El-hamid. "Protective effect of citicoline against aluminum-induced cognitive impairments in rats." Toxicology and Industrial Health 33, no. 4 (2016): 308–17. http://dx.doi.org/10.1177/0748233716641869.

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The potential protective effect of citicoline on aluminum chloride-induced cognitive deficits was investigated in rats. In a Morris water maze, administration of aluminum chloride to rats for 90 days resulted in increased escape latency to reach the platform and decreased swimming speed in acquisition trials. Similarly, in probe trials, the time required to reach the hidden platform was increased and the time spent in the target quadrant was reduced. Also, administration of aluminum chloride to rats for 90 days increased the reference and working memory errors and time required to end the task

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Park, Eunkuk, Min Jeong Ryu, Nam Ki Kim, et al. "Synergistic Neuroprotective Effect of Schisandra chinensis and Ribes fasciculatum on Neuronal Cell Death and Scopolamine-Induced Cognitive Impairment in Rats." International Journal of Molecular Sciences 20, no. 18 (2019): 4517. http://dx.doi.org/10.3390/ijms20184517.

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Mild cognitive impairment (MCI) is considered as a transitional stage between aging and Alzheimer’s disease. In the present study, we examined the protective effect of Schisandra chinensis (SC) and Ribes fasciculatum (RF) on neuronal cell death in vitro and scopolamine-induced cognitive impairment in Sprague Dawley® rats in vivo. A mixture of SC and RF extracts (SC+RF) significantly protected against hydrogen peroxide-induced PC12 neuronal cell death. The neuroprotective effect of SC+RF on scopolamine-induced memory impairment in rats was evaluated using the passive avoidance test and the Morr

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Khuman, Jugta, William P. Meehan, Xiaoxia Zhu, et al. "Tumor Necrosis Factor Alpha and Fas Receptor Contribute to Cognitive Deficits Independent of Cell Death after Concussive Traumatic Brain Injury in Mice." Journal of Cerebral Blood Flow & Metabolism 31, no. 2 (2010): 778–89. http://dx.doi.org/10.1038/jcbfm.2010.172.

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Tumor necrosis factor alpha (TNFα) and Fas receptor contribute to cell death and cognitive dysfunction after focal traumatic brain injury (TBI). We examined the role of TNFα/Fas in postinjury functional outcome independent of cell death in a novel closed head injury (CHI) model produced with weight drop and free rotational head movement in the anterior–posterior plane. The CHI produced no cerebral edema or blood–brain barrier damage at 24 to 48 hours, no detectable cell death, occasional axonal injury (24 hours), and no brain atrophy or hippocampal cell loss (day 60). Microglia and astrocytes

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Chinn, Gregory A., Jennifer M. Sasaki Russell, Nicole A. Yabut, Deenu Maharjan, and Jeffrey W. Sall. "Androgenic Modulation of the Chloride Transporter NKCC1 Contributes to Age-dependent Isoflurane Neurotoxicity in Male Rats." Anesthesiology 133, no. 4 (2020): 852–66. http://dx.doi.org/10.1097/aln.0000000000003437.

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Background Cognitive deficits after perinatal anesthetic exposure are well established outcomes in animal models. This vulnerability is sex-dependent and associated with expression levels of the chloride transporters NKCC1 and KCC2. The hypothesis was that androgen signaling, NKCC1 function, and the age of isoflurane exposure are critical for the manifestation of anesthetic neurotoxicity in male rats. Methods Flutamide, an androgen receptor antagonist, was administered to male rats on postnatal days 2, 4, and 6 before 6 h of isoflurane on postnatal day 7 (ntotal = 26). Spatial and recognition

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Shah, Akeel A., and Dallas Treit. "Infusions of midazolam into the medial prefrontal cortex produce anxiolytic effects in the elevated plus-maze and shock-probe burying tests." Brain Research 996, no. 1 (2004): 31–40. http://dx.doi.org/10.1016/j.brainres.2003.10.015.

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Bari, Ichsan Nurul, Nur’aini Herawati, and Syifa Nabilah Subakti Putri. "Effects of Oleander Leaves (Nerium oleander) against Metabolism, Activity Pattern, and the Leaves Potency as Rice-Field Rat Repellent (Rattus argentiventer)." Biology and Life Sciences Forum 4, no. 1 (2020): 37. http://dx.doi.org/10.3390/iecps2020-08868.

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Nerium oleander historically has been known worldwide as a poisonous plant that can be used to control pests. However, studies on the effects of oleander leaves against Rattus argentiventer as a major agricultural rodent pest are limited. This research aimed to probe the potency of oleander leaves extracted in methanol as a rice-field rat repellent. The experiments involved a choice test (T-maze arena) and a no-choice test (metabolic cage) that were analyzed by the T-test using three replications for 6 days. The results showed that the rats on the T-maze avoided consuming food and water near t

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Saldı́var-González, J. A., A. Posadas-Andrews, R. Rodrı́guez, et al. "Effect of electrical stimulation of the baso-lateral amygdala nucleus on defensive burying shock probe test and elevated plus maze in rats." Life Sciences 72, no. 7 (2003): 819–29. http://dx.doi.org/10.1016/s0024-3205(02)02335-4.

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Shah, Akeel A., and Dallas Treit. "Excitotoxic lesions of the medial prefrontal cortex attenuate fear responses in the elevated-plus maze, social interaction and shock probe burying tests." Brain Research 969, no. 1-2 (2003): 183–94. http://dx.doi.org/10.1016/s0006-8993(03)02299-6.

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An, Jian-xiong. "Trigeminal Neuralgia Induced by Cobra Venom in the Rat Leads to Deficits in Abilities of Spatial Learning and Memory." Pain Physician 2;18, no. 2;3 (2015): E207—E216. http://dx.doi.org/10.36076/ppj/2015.18.e207.

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Background: Patients with chronic pain usually suffer from cognitive impairment, with memory deterioration being the most common deficit that affects daily functioning and quality of life. The causes for this impairment are not clear despite intensive clinical studies. Few studies have evaluated impaired learning using animal models of persistent pain. Objective: In this study, a new trigeminal neuralgia model induced by cobra venom was adopted to explore effects of chronic pain on spatial learning and memory in rats. Study Design: Controlled animal study. Setting: Department of Anesthesiology

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Lin, Ming-Kuem, Meng-Shiou Lee, Hui-Chi Huang, Tun-Jen Cheng, Yih-Dih Cheng, and Chi-Rei Wu. "Cuscuta chinensis and C. campestris Attenuate Scopolamine-Induced Memory Deficit and Oxidative Damage in Mice." Molecules 23, no. 12 (2018): 3060. http://dx.doi.org/10.3390/molecules23123060.

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The seeds of Cuscuta chinensis Lam. and C. campestris Yuncker have been commonly used as Chinese medical material for preventing aging. Our previous studies have found that C. chinensis and C. campestris possess anti-inflammatory activities in rodents. However, their other biological activities, such as memory-improving properties, have not yet been explored. In the present study, we examined the memory-improving effects of the extracts of C. chinensis and C. campestris on scopolamine (SCOP)-induced memory deficit and explored their underlying mechanism in mice. Both Cuscuta species improved S

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Kupferschmid, Barbara J., Pamela J. Rowsey, and Michael Riviera. "Characterization of Spatial Learning and Sickness Responses in Aging Rats Following Recurrent Lipopolysaccharide Administration." Biological Research For Nursing 22, no. 1 (2019): 92–102. http://dx.doi.org/10.1177/1099800419875824.

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Infections in older individuals can result in cognitive function decline, yet research is limited on how recurrent infections affect cognitive responses. Activation of the immune system results in sickness responses mediated by cytokines. This pilot study examined effects of a model of recurrent infection in aged, male Brown Norway rats on sickness responses, including spatial learning, and cytokine levels. To model initial and recurrent infection, 300 μg/kg lipopolysaccharide (LPS) or saline was administered 1/day for 2 consecutive days during 2 weeks separated by 16 days. Testing occurred fo

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Ji, Shengjun, Ming Yang, and Jinming Yu. "TrkA neurotrophin receptor and PI3K-Akt signaling involvement in cranial irradiation-induced memory deficit." Journal of Clinical Oncology 37, no. 15_suppl (2019): e14679-e14679. http://dx.doi.org/10.1200/jco.2019.37.15_suppl.e14679.

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e14679 Background: This study aimed to investigate the role of neurotrophin receptor TrkA in cranial radiation-induced memory decline. Methods: Single dose of 10Gy 4MeV electron beam whole brain irradiation (WBI) was given to young male Sprague-Dawley rats (50–60g, day 21). 3 months after WBI, western blot was performed to detect protein level of TrkA and its downstream signaling molecules. The Morris water maze test was performed to evaluate the consequence of WBI on hippocampus-dependent memory formation. Immunohistochemistry was performed to evaluate the consequence of WBI on neurogenesis.

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Hakvoort Schwerdtfeger, Rebecca M., and Janet L. Menard. "The lateral hypothalamus and anterior hypothalamic nucleus differentially contribute to rats' defensive responses in the elevated plus-maze and shock-probe burying tests." Physiology & Behavior 93, no. 4-5 (2008): 697–705. http://dx.doi.org/10.1016/j.physbeh.2007.11.011.

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Dringenberg, Hans C., Yonina Levine, and Janet L. Menard. "Electrical stimulation of dorsal, but not ventral hippocampus reduces behavioral defense in the elevated plus maze and shock-probe burying test in rats." Behavioural Brain Research 186, no. 1 (2008): 143–47. http://dx.doi.org/10.1016/j.bbr.2007.07.030.

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An, Jianxiong. "Trigeminal Neuralgia Induced by Cobra Venom Leads to Cognitive Deficits Associated with Downregulation of CREB/BDNF Pathway." Pain Physician 2, no. 20;2 (2017): 53–67. http://dx.doi.org/10.36076/ppj/2017/67.

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Background: Chronic pain often results in cognitive impairment. Our previous study showed that trigeminal neuralgia induced by cobra venom leads to spatial learning and memory deficits, although the underlying mechanism remains unclear. However, recent evidence indicates that the c-AMP-responsive element binding protein (CREB)/brain derived neurotrophic factor (BDNF) pathway plays a critical role in various etiologies of cognitive deficits. Objectives: Our aim was to explore the CREB/BDNF pathway to determine the molecular mechanisms involved in the pathogenesis of cognitive impairment caused

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Callaway, Jennifer K., Nigel C. Jones, Alistair G. Royse, and Colin F. Royse. "Sevoflurane Anesthesia Does Not Impair Acquisition Learning or Memory in the Morris Water Maze in Young Adult and Aged Rats." Anesthesiology 117, no. 5 (2012): 1091–101. http://dx.doi.org/10.1097/aln.0b013e31826cb228.

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Background Sevoflurane has been found to increase apoptosis and pathologic markers associated with Alzheimer disease, provoking concern over their potential contribution to postoperative cognitive dysfunction. Methods The effects of anesthesia with 1 minimum alveolar concentration of sevoflurane for 4 h or sham exposure on cognition were investigated in young adult and aged (20-24 months) rats at 1, 4, and 12 weeks postexposure. Spatial reference memory acquisition and retention were tested in the Morris water maze task. Latency to locate the hidden platform and swim speed were determined and

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Upadhyaya, Shreeraksha, Shivaprakash Gangachannaiah, and Pallavi Lakshmi Chandrashekar. "Effect of Piper betel leaf extract on learning and memory in Aluminium chloride induced Alzheimer’s disease in Wistar rats." Biomedical & Pharmacology Journal 12, no. 3 (2019): 1425–31. http://dx.doi.org/10.13005/bpj/1771.

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Alzheimer's disease is a common neurological disorder affecting a significant proportion of the elderly population.There are only a few drugs which can be used safely to treat it. We sought to investigate for the first time Piper betel leaf, a postmeal mouth freshener for its potential use in Alzheimer's disease. Five groups of male Wistar rats with six rats in each group aged 10-12 weeks were used. The control group received the distilled water, aluminium chloride (AlCl3) group was treated with AlCl3, the standard group was treated with rivastigmine with AlCl3, and the two test groups receive

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Othman, Manal, Ebrahim Rajab, Ahmed AlMubarak, Mohammed AlNaisar, Noora Bahzad, and Amer Kamal. "Erythropoietin Protects Against Cognitive Impairment and Hippocampal Neurodegeneration in Diabetic Mice." Behavioral Sciences 9, no. 1 (2018): 4. http://dx.doi.org/10.3390/bs9010004.

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Administration of erythropoietin (EPO) is neuroprotective against a variety of experimentally-induced neurological disorders. The aim was to determine if EPO protects against hippocampal neurodegeneration as well as impairment of cognition and motor performance, associated with long-term diabetes. BALB/c mice were randomly allocated between control, diabetic and EPO-treated diabetic groups. EPO-treated diabetic mice were administered EPO 0.05 U/kg/day i.p. three times/week for 10 weeks. Cognition was assessed by Morris water maze. Brain samples were processed for light microscopic evaluation o

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Yang, Ying-Chen, Chia-Nan Chen, Carol-Imei Wu, et al. "NBM-T-L-BMX-OS01, Semisynthesized from Osthole, Is a Novel Inhibitor of Histone Deacetylase and Enhances Learning and Memory in Rats." Evidence-Based Complementary and Alternative Medicine 2013 (2013): 1–18. http://dx.doi.org/10.1155/2013/514908.

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NBM-T-L-BMX-OS01 (BMX) was derived from the semisynthesis of osthole, isolated fromCnidium monnieri(L.) Cuss., and was identified to be a potent inhibitor of HDAC8. This study shows that HDAC8 is highly expressed in the pancreas and the brain. The function of HDAC8 in the brain has not been adequately studied. Because BMX enhances neurite outgrowth and cAMP response element-binding protein (CREB) activation, the effect of BMX on neural plasticity such as learning and memory is examined. To examine declarative and nondeclarative memory, a water maze, a passive one-way avoidance task, and a nove

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Nolan, Suzanne O., and Joaquin N. Lugo. "Reversal learning paradigm reveals deficits in cognitive flexibility in the Fmr1 knockout male mouse." F1000Research 7 (June 7, 2018): 711. http://dx.doi.org/10.12688/f1000research.14969.1.

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Background: Loss of FMR1 is associated with Fragile X syndrome, amongst the most prevalent inherited intellectual disability. Despite extensive research in this area, previous studies have failed to detect consistent evidence of cognitive impairments in the Morris water maze (MWM) task in the Fmr1 knockout (KO) mouse. However, few studies have examined cognitive flexibility in a reversal form of the MWM task, which may illuminate subtle learning deficits. Methods: Adult male Fmr1 wildtype (WT) and KO mice were bred and tested in the MWM reversal paradigm. The testing paradigm consisted of two

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Bonaccorsi, Joyce, Simona Cintoli, Rosa Mastrogiacomo, et al. "System Consolidation of Spatial Memories in Mice: Effects of Enriched Environment." Neural Plasticity 2013 (2013): 1–12. http://dx.doi.org/10.1155/2013/956312.

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Environmental enrichment (EE) is known to enhance learning and memory. Declarative memories are thought to undergo a first rapid and local consolidation process, followed by a prolonged process of system consolidation, which consist in a time-dependent gradual reorganization of brain regions supporting remote memory storage and crucial for the formation of enduring memories. At present, it is not known whether EE can affect the process of declarative memory system consolidation. We characterized the time course of hippocampal and cortical activation following recall of progressively more remot

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Careena, S., D. Sani, S. N. Tan, et al. "Effect of Edible Bird’s Nest Extract on Lipopolysaccharide-Induced Impairment of Learning and Memory in Wistar Rats." Evidence-Based Complementary and Alternative Medicine 2018 (August 14, 2018): 1–7. http://dx.doi.org/10.1155/2018/9318789.

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Cognitive disability is a common feature associated with a variety of neurological conditions including Alzheimer’s Disease (AD), Parkinson’s Disease (PD), brain injury, and stroke. Emerging evidence has demonstrated that neuroinflammation plays an important role in the development of cognitive impairment. Current available therapies are relatively ineffective in treating or preventing cognitive disabilities, thus representing an important, unfulfilled medical need. Hence, developing potential treatment is one of the major areas of research interest. Edible bird’s nests (EBN) are nests formed

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Moriarty, Orla, Claire L. Gorman, Fiona McGowan, et al. "Impaired recognition memory and cognitive flexibility in the rat L5–L6 spinal nerve ligation model of neuropathic pain." Scandinavian Journal of Pain 10, no. 1 (2016): 61–73. http://dx.doi.org/10.1016/j.sjpain.2015.09.008.

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AbstractBackground and aimsAlthough neuropathic pain is known to negatively affect cognition, the neural mechanisms involved are poorly understood. Chronic pain is associated with changes in synaptic plasticity in the brain which may impact on cognitive functioning. The aim of this study was to model neuropathic pain in mid-aged rats using spinal nerve ligation (SNL). Following establishment of allodynia and hyperalgesia, behaviour was assessed in a battery of cognitive tests. Expression of the presynaptic protein, synaptophysin, and its colocalisation with the vesicular GABA and glutamate tra

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Mackay, M. K., and N. Pillay. "Similarities in spatial cognition in sister species of the striped mouse Rhabdomys originating from different ecological contexts." Behaviour 154, no. 13-15 (2017): 1397–420. http://dx.doi.org/10.1163/1568539x-00003474.

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Abstract Variation in spatial cognition is correlated with differences in the environments where animals originate, such that different environments might select for different cognitive ability. We investigated whether three sister species of the striped mouse genus Rhabdomys differed in their spatial cognition. The species originated from three locations across a rainfall gradient in southern Africa, which vary in habitat complexity. We tested individuals in a modified Barnes maze and asked whether the species had different spatial memory and navigation and whether these differences were rela

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