Relevant bibliographies by topics / MBL

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  1. Journal articles
  2. Dissertations / Theses
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  5. Conference papers
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Academic literature on the topic 'MBL'

Author: Grafiati
Published: 4 June 2021
Last updated: 11 March 2023

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Journal articles on the topic "MBL"

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Rakhshandehroo, Maryam, Rinke Stienstra, Nicole J. de Wit, Marjolijn C. E. Bragt, Martin Haluzik, Ronald P. Mensink, Michael Müller, and Sander Kersten. "Plasma mannose-binding lectin is stimulated by PPARα in humans." American Journal of Physiology-Endocrinology and Metabolism 302, no. 5 (March 1, 2012): E595—E602. http://dx.doi.org/10.1152/ajpendo.00299.2011.

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The peroxisome proliferator activated receptor-α (PPARα) is a major transcriptional regulator of lipid metabolism in liver and represents the molecular target for hypolipidemic fibrate drugs. Effects of PPARα on lipid metabolism are partially mediated by circulating proteins such as FGF21 and ANGPTL4. The present study was undertaken to screen for and identify circulating proteins produced by human liver that are under the control of PPARα. Toward that aim, primary human hepatocytes were treated with the synthetic PPARα agonist Wy-14643 and whole genome expression data selected for secreted proteins. Expression of FGF21, ANGPTL4, and mannose-binding lectin (MBL), a soluble mediator of innate immunity and primary component of the lectin branch of the complement system, was markedly upregulated by Wy-14643 in primary human hepatocytes. Mice express two MBL isomers, Mbl1 and Mbl2. Mbl1 mRNA was weakly induced by Wy-14643 in primary mouse hepatocytes and remained unaltered by Wy-14643 in mouse liver. Mbl2 mRNA was unchanged by Wy-14643 in primary mouse hepatocytes and was strongly reduced by Wy-14643 in mouse liver. Remarkably, plasma Mbl1 levels were increased by chronic PPARα activation in lean and obese mice. Importantly, in two independent clinical trials, treatment with the PPARα agonist fenofibrate at 200 mg/day for 6 wk and 3 mo increased plasma MBL levels by 73 ( P = 0.0016) and 86% ( P = 0.017), respectively. It is concluded that hepatocyte gene expression and plasma levels of MBL are stimulated by PPARα and fenofibrate in humans, linking PPARα to regulation of innate immunity and complement activation in humans and suggesting a possible role of MBL in lipid metabolism.
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Mullighan, Charles G., Susan L. Heatley, Silke Danner, Melinda M. Dean, Kathleen Doherty, Uwe Hahn, Kenneth F. Bradstock, et al. "Mannose-binding lectin status is associated with risk of major infection following myeloablative sibling allogeneic hematopoietic stem cell transplantation." Blood 112, no. 5 (September 1, 2008): 2120–28. http://dx.doi.org/10.1182/blood-2007-07-100222.

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Abstract Mannose-binding lectin (MBL) is a mediator of innate immunity that influences the risk of infection in a range of clinical settings. We previously reported associations between MBL2 genotype and infection in a retrospective study of myeloablative allogeneic hematopoietic stem cell transplantation (allo-HCT). However, other studies have been inconclusive, and the role of MBL in reduced-intensity conditioning (RIC) transplantation is unknown. Here we report a prospective study examining MBL2 genotype, MBL levels, and risk of major infection following HLA-matched sibling myeloablative (n = 83) and RIC (n = 59) HCT. Baseline MBL levels were higher in recipients than donors (P < .001), and recipient MBL levels increased during the peritransplantation period (P = .001), most notably in MBL2 wild-type individuals receiving myeloablative total body irradiation (mTBI). MBL2 coding mutations were associated with major infection in recipients receiving mTBI. The cumulative incidence of major infection in recipient harboring an MBL2 mutation receiving mTBI was 70.6%, compared with 31.1% of those without mutations not receiving mTBI (P = .01). MBL status was not associated with infection in RIC transplants. These results confirm the association of MBL status with risk of infection in myeloablative, TBI-conditioned transplantation. Studies examining the role of MBL replacement therapy to prevent infection in this setting should be considered.
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Papanicolaou, G. A., C. Mihu, K. Kadeishvili, M. Doll, D. Stokar, A. Buchbinder, K. Hsu, R. O'Reilly, E. G. Pamer, and J. Satagopan. "Association of MBL2 genotypes wtih infections and outcome after allogeneic stem cell transplantation." Journal of Clinical Oncology 25, no. 18_suppl (June 20, 2007): 7100. http://dx.doi.org/10.1200/jco.2007.25.18_suppl.7100.

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7100 Background: Low MBL2 concentration and MBL2 genotype variants have been associated with an increased risk of infection. Our objective was to correlate MBL2 genotypes with specific infections and outcome of HSCT. Methods: 125 non- consecutive, non-selected HSCT were examined. Patients were classified as high or low risk group based on status of underlying disease. Antifungal prophylaxis consisted of fluconazole 400 mg daily. Patients on steroids received mould prophylaxis. There was no routine antibacterial prophylaxis. Microbiologically confirmed infections were recorded. Genotype was determined by PR-Melting Curve Analysis on blood or buccal swab specimens. MBL genotype was classified as wild-type: A/A (MBL-sufficient, MBL-S) or variant-type: A/O, O/O (MBL deficient, MBL- D). Patients were followed for up to 2 years. Analyses of categorical variables were performed using the Fisher exact test and the Log-Rank test for time to event. Results: Seventy-one (58.2%) patients were homozygous for wild-type MBL2 (AA), 43 (35.3%) were heterozygous (A/0) and 8 (6.5%) were homozygous for variant genotypes (OO). MBL-D group had higher incidence of fungal infections (20% vs 7%, p=0.05), and in particular Aspergillosis (12% vs 3%, p=0.05). MBL-D was associated with a trend for higher rates of bacterial infections (63% vs 46%, p=0.10) and total number of bacterial infections (p=0.10). Rates of respiratory and enteric viral infections or CMV were similar in MBL-D and MBL-S groups (41% vs 38%, p=0.9 and 58% vs. 54% p=1.0 respectively). Patients with MBL-D genotype were at a disadvantage in relapse-free (RFS) and overall survival (OS), (p<0.01 and p=.08). This disadvantage was also observed when stratified by disease risk groups. The estimated 2-year relapse-free survival rate was 30% compared to 53% for MBL-D vs. MBL-S patients (p<0.01). Conclusions: 1) Patients with variant MBL genotype (MBL-D) had a trend for increased incidence and number of bacterial infections. 2) MBL-D genotype and graft versus host disease were risk factors for aspergillosis. 3) MBL-D genotype was associated with worse overall survival and relapse free survival post HSCT. These data suggest that MBL-D patients have impaired immune function compared with MBL-S patients and is consistent with animal data. [Table: see text]
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Kumari, Minal, Yogesh Kumar, and Parvinder Kaur. "Effectiveness of Module Based Learning regarding Facility Based Newborn Care in terms of knowledge and practices among nursing students." International Journal of Contemporary Pediatrics 6, no. 5 (August 23, 2019): 2184. http://dx.doi.org/10.18203/2349-3291.ijcp20193749.

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ABSTRACTBackground: Mobile Applications are being developed at a rapid speed and are intensively used by students. It can help to achieve better performance in organizing, managing, and monitoring classroom activities.Aims and objectives: Present study aimedto assess and compare the knowledge and practice regarding FBNC among nursing students in MBL group and MABL group before and after the administration of MBL and MABL. The conceptual framework of the study was based on CIPP model by Stufflebeam.Methods: A Quantitative research approach with quasi-experimental and non-equivalent controlgroup pre–test post–test design. The study was conducted at two nursing colleges of Ambala, Haryana. A total of 70 B.Sc. Nursing 3rd Year students, randomly allocated to 2 groups i.e. 35 in MBL and 35 in MABL. The tool used for the study consisted of structured knowledge questionnaire and observational check list was used to assess knowledge and practices by OSCE method of nursing students regarding FBNC. Data collection was done in January, 2017. The obtained data was analyzed and interpreted in terms of objectives and researchResults: Findingsof the study indicate that revealed that mean post- test knowledge and practices score in MBL group (21.4 ±0.89) and in MABL group (22.4 ± 0.54) was significantly higher than pre-test knowledge score in MBL group (14.6±15.0) and in MABL group (16.2±17.0). Also, the mean post-test practice score in MBL group (38.1±1.91) and in MABL group (38.9± 1.20) was significantly higher than pre-test practicescore in MBL (20.4 ± 3.70) as well as in MABL group (20.5 ± 4.26). Mild positive significant relationship (r=0.03) was found between post test score of knowledge and practicesConclusion: MABL was more effective in developing the practices of nursing students regarding FBNC than MBL.
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Chung, Dick, Lily Ding, Isabelle Amigues, Katuna Kadeishvili, Theresa Lo, Eric Pamer, Stacey Kalambakas, Aby Buchbinder, and Genovefa Papanicolaou. "Association of Mannose Binding Lectin (MBL-2) Deficiency with Pulmonary Infection after Allogeneic Hematopoietic Stem Cell Transplantation (HSCT)." Blood 112, no. 11 (November 16, 2008): 2209. http://dx.doi.org/10.1182/blood.v112.11.2209.2209.

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Abstract Background: Low MBL2 concentration and MBL2 genotype variants have been associated with an increased risk of infection in various clinical settings. Pulmonary infection is a major complication of HSCT. We examined the relationship of MBL genotypes with post-engraftment bacterial (B-PNA) and fungal (F-PNA) pneumonia Methods: Retrospective review of 236 non-consecutive, non-selected patients who underwent HSCT at MSKCC from 1/1/2000–4/30/2007. Microbiologically confirmed infections and pneumonias were recorded. Antifungal prophylaxis consisted of fluconazole 400 mg daily. Patients at high risk for mold infection received mold-active prophylaxis. After 1/1/2006 voriconazole was the first line anti-mold prophylaxis. Genotype was determined by PR-Melting Curve Analysis on blood or buccal swab specimens. MBL genotype was classified as wild-type: A/A (MBL-sufficient, MBL-S) or variant-type: A/O, O/O (MBL deficient, MBL-D). Patients were followed for up to 2 years. Statistical analysis: Fisher’s Exact test was used to compare the incidence rate between MBL-S and MBL-D patients. Multivariate logistical regression models were used to investigate the relationship between bacterial or fungal pneumonia and MBL genotype, matched related donor (MRD), myeloablative conditioning (MC) peripheral blood as stem cell source (PBSC), acute GVHD grade 2–4 (aGVHD). The results from Maximum Likelihood Estimates were summarized. Results: Transplant characteristics: 80% MC, 76% PBSC, 48.6% MRD. Incidence of aGVHD: 22.4%. MBL genotypes: One-hundred and forty-two (60%) patients were homozygous for wild-type MBL2 (AA), 85(36%) were heterozygous (A/0) and 9 (3.8%) were homozygous for variant genotypes (OO). Transplant characteristics, rates of GVHD, relapse-free and overall survival were similar between MBL-D and MBL-S. There was higher incidence of overall bacterial infections in MBL-D compared to MBL-S pts (47.87% vs 36.62%, p=0.1049). MBL-D had a higher incidence of B-PNA (12.7% vs 4.9%, p=0.048). In multivariate logistic regression analysis, MBL-D(p=0.04) and aGVHD(p=0.06) were likely associated with B-PNA. Rates of overall fungal infections and F-PNA were similar [among MBL-D and MBL-S pts (12.77% vs 9.86%, p=0.5277) and (8.51% vs 7.75%, p=0.1049) respectively]. In multivariate logistic regression analysis only aGVHD was statistically significantly associated with F-PNA p=0.0002. Conclusions: 1) MBL-D genotype was likely associated with increased risk of bacterial pneumonia. 2) MBL-D and aGVHD were risk factors for B-PNA. 3) Further analyses are in progress to evaluate the effect of MBL-D on fungal pneumonia in patients who received mold prophylaxis versus patients who did not receive mold prophylaxis. 4) Prospective studies are needed to assess the relative contribution of MBL-D genotype on the risk of pulmonary infection in HSCT.
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Kashiwagi, Yasuyo, Shinji Suzuki, Ryo Takahashi, Gaku Yamanaka, Yuji Hirai, and Hisashi Kawashima. "Association of the Mannose-Binding Lectin 2 BB Genotype with COVID-19-Related Mortality." Life 13, no. 2 (January 30, 2023): 382. http://dx.doi.org/10.3390/life13020382.

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Mannose-binding lectin (MBL) is crucial in first-line immune defenses. There are still many unknown factors regarding the mechanisms causing variability in the clinical course of coronavirus disease 2019 (COVID-19). In Japan, there have been few reports to date regarding the association between MBL and COVID-19. It has been demonstrated that the MBL2 gene B variant at codon 54 (rs1800450) is associated with variabilities in the clinical course of COVID-19. We aimed to investigate how the level of serum MBL and the codon 54 variant of MBL (rs1800450) affect the disease severity of COVID-19. A total of 59 patients from the fourth wave and 49 patients from the fifth wave in Japan were analyzed based on serum MBL levels using ELISA and the genotype of MBL2 codon 54 using PCR reaction. There was no significant association between serum MBL levels and age. MBL2 genotype was independent of age, there was no significant difference in different COVID-19 severities, MBL genotypes, and serum MBL levels. Binary logistic regression analysis to identify predisposing factors for severe COVID-19 symptoms demonstrated that patients with the BB genotype had a higher risk of death from COVID-19. Our results quantitatively demonstrated that the BB genotype might be a factor associated with death from COVID-19.
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Baioumy, Shereen A., Shaimaa H. Fouad, Shaimaa A. Abdalgeleel, Ahmed A. Baiomy, Dina E. Sallam, and Sara I. Taha. "Mannose-binding lectin serum levels and (Gly54asp) gene polymorphism in recurrent aphthous stomatitis: A case-control study." International Journal of Immunopathology and Pharmacology 35 (January 2021): 205873842110644. http://dx.doi.org/10.1177/20587384211064454.

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Objectives: Dysregulation of the immune response appears to play a significant role in recurrent aphthous stomatitis (RAS) development. The main objective of this case–control study is to investigate the blood levels of mannose-binding lectin (MBL) and the frequency of the MBL2 gene (gly54asp) polymorphism in RAS patients, including 40 RAS patients and 40 healthy controls. Methods: Serum MBL levels were determined by ELISA, while the PCR-restriction fragment length polymorphism was used in MBL2 genotyping. Results: The median serum MBL level was significantly lower in the RAS group than in the control group (975 ng/mL (545–1320) vs. 1760 ng/mL (1254–2134); p≤ 0.001). The MBL levels were significantly lower in the BB genotype, whereas they were significantly higher in the wild type AA with a median of 525 and 1340 ng/mL, respectively ( p =0.005). The B allele was expressed in significantly higher percentages of RAS patients than in controls. There was no significant association between MBL serum levels ( p=0.685) or MBL2 codon 54 genotypes ( p=0.382) with the type of ulcers. Conclusion: There was an association between low MBL serum levels and the variant allele B of the MBL2 (gly54asp) gene, and the susceptibility to RAS. As a result, potential novel therapeutic options for RAS patients with MBL deficiency should be investigated.
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Thio, Chloe L., Timothy Mosbruger, Jacquie Astemborski, Spencer Greer, Gregory D. Kirk, Stephen J. O'Brien, and David L. Thomas. "Mannose Binding Lectin Genotypes Influence Recovery from Hepatitis B Virus Infection." Journal of Virology 79, no. 14 (July 2005): 9192–96. http://dx.doi.org/10.1128/jvi.79.14.9192-9196.2005.

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ABSTRACT Mannose binding lectin (MBL) is a central component of the innate immune response and thus may be important for determining hepatitis B virus (HBV) persistence. Since single-nucleotide polymorphisms (SNPs) in the gene encoding MBL (mbl2) alter the level of functional MBL, we hypothesized that mbl2 genotypes are a determinant of HBV persistence or recovery from viral infection. We tested this hypothesis by using a nested case control design with 189 persons with HBV persistence matched to 338 individuals who had naturally recovered from HBV infection. We determined genotypes of two promoter and three exon 1 SNPs in mbl2 and grouped these genotypes according to the amount of functional MBL production. We found that the promoter SNP −221C, which leads to deficient MBL production, was more common in those subjects with viral persistence (odds ratio [OR], 1.38; 95% confidence interval [CI], 1.01 to 1.89; P = 0.04). Those subjects homozygous for the combination of promoter and exon 1 genotypes associated with the highest amount of functional MBL had significantly increased odds of recovery from infection (OR, 0.55; 95% CI, 0.37 to 0.84; P = 0.005). Conversely, those homozygous for the combination of promoter and exon 1 genotypes which produce the lowest amount of functional MBL were more likely to have viral persistence (OR, 1.76; 95% CI, 1.02 to 3.01; P = 0.04). These data are consistent with the hypothesis that functional MBL plays a central role in the pathogenesis of acute hepatitis B.
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Mullighan, Charles G., Susan E. Heatley, Silke Danner, Melinda Dean, Kathleen V. Doherty, Uwe Hahn, Kenneth Bradstock, et al. "Mannose-Binding Lectin Status Is Associated with Risk of Major Infection Following Myeloablative Sibling Allogeneic Hematopoietic Stem Cell Transplantation." Blood 108, no. 11 (November 16, 2006): 2928. http://dx.doi.org/10.1182/blood.v108.11.2928.2928.

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Abstract Infection is a leading cause of morbidity following allogeneic hematopoietic stem cell transplantation (allo-HCT). In a previous retrospective study of related, HLA-matched myeloablative transplants, we identified associations between common inherited polymorphisms in the MBL2 gene encoding the mediator of innate immunity, mannose-binding lectin (MBL), and risk of major infection. Missense mutations resulting in low circulating MBL levels were associated with increased infection, and high-producing promoter haplotypes were protective. However, subsequent studies have been conflicting, there are no data examining non-myeloablative transplants, and the relationship between MBL2 genotype and serum MBL levels peri-transplant has not been studied. This is important as MBL is an acute phase reactant primarily synthesized by the liver, and many conditioning regimens are hepatotoxic. Here we report a prospective study examining MBL2 genotype, MBL levels and risk of major infection following HLA-matched sibling myeloablative and non-myeloablative allo-HCT. Data is available for 138 transplants, 81 myeloablative and 57 non-myeloablative. 49 of the myeloablative transplants utilized total body irradiation (TBI) based conditioning regimens. Five promoter and missense MBL2 polymorphisms were genotyped, and plasma MBL mannan-binding and C4-deposition levels were measured pretransplant for donor and recipient, and at days 0, 14 and 28 post-transplant. Major infection was defined as invasive or systemic episodes of microbiologically confirmed sepsis. MBL levels were higher in recipients than donors at baseline (t test P<0.0001), reflecting an acute phase response induced by disease and prior treatment. Recipient MBL levels increased during the peritransplant period (ANOVA P=0.0002), most strikingly in individuals without MBL2 coding mutations undergoing TBI. 59 of 138 (42.8%) recipients experienced at least one episode of major infection (myeloablative 38/81, 46.9%, non-myeloablative 21/57 (36.8%), P=NS). The most significant clinical risk factor for infection was the use of myeloablative TBI (HR 2.8, CI 1.39–5.8, p=0.004). Analyzing all transplants, MBL2 genotype (recipient P=0.07, donor p=0.08), and recipient mannan-binding MBL levels (P=0.10) were weak risk factors for infection, however the association was highly dependent upon the type and intensity of conditioning. No association was observed in non-myeloablative transplants, but a significant interaction was observed between recipient MBL2 coding mutations and the use of TBI in myeloablative transplants (Cox P=0.002). For example, 70.6% of recipients with a coding MBL2 mutation receiving TBI developed major sepsis, compared with 20% of those without mutations not receiving TBI. Our results confirm the association of MBL status with risk of infection risk post allo-HCT. Importantly, the association is restricted to myeloablative, TBI-conditioned transplants. Further studies examining the role of MBL replacement in this setting are warranted.
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Friborg, Jeppe T., Ruth F. Jarrett, Anders Koch, Peter Garred, June M. L. Freeland, Andreas Andersen, and Mads Melbye. "Mannose-Binding Lectin Genotypes and Susceptibility to Epstein-Barr Virus Infection in Infancy." Clinical and Vaccine Immunology 17, no. 9 (July 7, 2010): 1484–87. http://dx.doi.org/10.1128/cvi.00527-09.

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ABSTRACT In a cohort study of children <4 years of age in Greenland, mannose-binding lectin (MBL2) genotypes and Epstein-Barr virus (EBV) antibody levels were determined. EBV seropositivity was significantly lower and time to seroconversion increased in MBL-insufficient compared with MBL-sufficient children, indicating that MBL may be involved in primary EBV infection in infancy.
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Dissertations / Theses on the topic "MBL"

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Wong, Kam-Ho Nicky. "Characterisation of complement activation via mannose-binding lectin (MBL) and MBL-associated serine proteases (MASPs)." Thesis, University of Oxford, 1998. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.298725.

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Buhre, Daniel. "Samverkansavtal, medbestämmande eller kringgående av MBL?!" Thesis, Linnéuniversitetet, Institutionen för ekonomistyrning och logistik (ELO), 2013. http://urn.kb.se/resolve?urn=urn:nbn:se:lnu:diva-28792.

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AbstractIn this study, then collaboration agreement impact of the work on 11 and 19 § § MBL are studied. The employer and collective agreements bearing employee union are often involved in collaborative agreements to facilitate cooperation between them. Issues addressed to collaboration areoften questions related to employee participation. The purpose of this study is to investigate two local employers and related collective bearing employee unionsview of the cooperation agreement related to the MBL. The purpose leads to these questions:How can co-operation agreements affect 11 and 19 § § MBL?What are theadvantages and disadvantages cooperation agreementscan lead to, regardingemployer disclosure and negotiation duty?To try to sort out these issues are interviews conducted to create a greater understanding of the work of the Cooperation Agreement between organizations and how it affects them.Results of the study suggest that collaboration agreement leads to simplifications in the work of the employer's information and bargaining duty. Other positive effects of the cooperation agreement arebetter and more permanent dialogue between the parties. Co-determination of employees are increased and thecooperation between the parties are leading to time-saving effects for both parties.Drawbacks to the collusive agreement emerging from the study are the risk that the issues are less negotiated. It also emerged that there is a risk that the collective supporting employees' feel run over by some negotiations. However, it was considered the highest risk in cooperative agreement be ambiguity in the terms and under which section of the law for consideration, which may lead to wrong decisions.However, my overall impression is that the positive effects of the cooperation agreement outweigh the negatives and that the cooperation agreement is a great way to bring together employers and the collective income workers and to increase co-determination of employeesKey words: cooperative agreement, disclosure, negotiation duty
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Landelius, Daniel, and Jesper Liljegren. "Arbetsgivares skyldighet att lämna ut information enligt LEF och MBL." Thesis, Linköpings universitet, Affärsrätt, 2015. http://urn.kb.se/resolve?urn=urn:nbn:se:liu:diva-121661.

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Uppsatsen utreder arbetsgivares skyldighet att lämna ut information enligt Lag (2011:427) om europeiska företagsråd (LEF). Utredningen görs genom en jämförelse med vad som föreskrivs i Lag (1976:580) om medbestämmande i arbetslivet (MBL), med särskild tonvikt på dess 19 §. Uppsatsen granskar vilken information som ett företag kan vara skyldigt att lämna ut med stöd i LEF respektive 19 § MBL och preciserar vilka typer av information som omfattas, när den ska lämnas ut och till vilken mottagare. Utifrån det material som framkommer av utredningen analyserar författarna hur skyldigheten att lämna ut information enligt LEF skiljer sig från motsvarande skyldighet i MBL.
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Palmér, Marianne. "Arbetsgivarens förhandlingsskyldighet : 11 § MBL i teori och praktik." Thesis, Växjö University, School of Management and Economics, 2007. http://urn.kb.se/resolve?urn=urn:nbn:se:vxu:diva-1235.

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Enligt 11 § MBL är arbetsgivaren skyldig att på eget initiativ kalla till förhandling innan han/hon fattar beslut i frågor som utgör viktigare förändring av hans/hennes verksamhet eller av arbets- eller anställningsförhållandena för arbetstagarna. Denna primära förhandlingsskyldighet gäller endast mot de kollektivavtalsslutande arbetstagarorganisationerna.

Syftet med uppsatsen är dels att belysa den här primära förhandlingsskyldigheten och dels beskriva hur den kan tillämpas i praktiken. Frågeställningarna som behandlas är därför följande: Kan arbetsgivaren identifiera de frågor som hör hemma i 11 § MBL? Förhandlar arbetsgivaren enligt 11 § MBL? Finns det andra sätt att komma överens än genom förhandling? Är förhandlingsskyldigheten en nackdel eller är det en fördel att MBL finns för relationerna mellan parterna på arbetsmarknaden? För att kunna besvara dessa frågor ges först en teoretisk inblick i 11 § MBL medan en undersökning vidtogs på ett företag i syfte att studera den praktiska tillämpningen av nämnda lagrum.

På företaget där undersökningen ägde rum har tillämpningen av arbetsgivarens primära förhandlingsskyldighet enligt 11 § MBL anpassats till verksamheten genom ett Utvecklingsavtal. Företaget ifråga har stående möten en gång i veckan där personalchefen, en personalkonsult och de fyra kollektivavtalsslutande arbetstagarorganisationerna är närvarande. På dessa mötens agenda står företagets verksamhets- och bemanningsfrågor. Syftet med 11 § MBL är att parterna ska verka för att nå gemensamma beslut och där tycker jag att det aktuella företaget har uppvisat ett väl fungerande arbetssätt.

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Oddo, Julia C. (Julia Christine). "Exploring the functional conservation of muscleblind (Mbl) proteins." Thesis, Massachusetts Institute of Technology, 2015. http://hdl.handle.net/1721.1/101357.

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Thesis: S.M., Massachusetts Institute of Technology, Department of Biology, 2015.
Cataloged from PDF version of thesis.
Includes bibliographical references (pages 54-59).
Muscleblind (Mbl) is an evolutionarily conserved family of proteins involved in many aspects of RNA metabolism, including alternative splicing. Disruption of Muscleblind in several animals lends to a variety of defects and disease, including the multi-systemic disorder Myotonic Dystrophy (DM). Though much is known about the involvement of Muscleblind in DM, there is much basic knowledge of the protein's function to be discovered. We approach this problem by exploring the functional conservation of a diverse subset of Muscleblind homologs. The functions of Muscleblinds from a basal metazoan, Trichoplax adhaerens, a primitive chordate, Ciona intestinalis, and the model organisms, Drosophila melanogaster and Caenorhabditis elegans were compared to human Muscleblind-like (MBNL). The zinc finger RNA-binding domains are the most conserved region between homologs, suggesting a conserved role in RNA binding and splicing regulation. To test this, we used splicing reporter assays with validated human MBNL-regulated mini-genes and performed RNA sequencing experiments in mouse embryonic fibroblasts (MEFs). Additionally, we accessed the subcellular localization of the homologs to determine conservation of extra-nuclear functions. Reporter assays in HeLa cells showed that the homologs can positively and negatively regulate splicing. Our RNA-seq experiments led us to discover hundreds of endogenously regulated splicing events, including the identity of the transcripts, direction of splicing regulation, types of splicing events, and the magnitude of alternate exon inclusion in the spliced mRNAs. Additionally, we identified a spectrum of splicing events, from those uniquely regulated by a single Muscleblind, to events regulated by all Muscleblinds, and, characterized the variation in splicing activity that exists between homologs. A subset of events regulated by mammalian Muscleblind were oppositely regulated by non-mammalian homologs. Muscleblinds show nuclear-cytoplasmic localization, which suggests conservation in extra-nuclear functions. In conjunction with exon and intron sequences, this information provides a future tool to discover conserved and novel RNA regulatory elements used by diverse Muscleblinds to regulate splicing and in putative cytoplasmic functions. These data could also be used to determine functionally important residues in Muscleblind proteins and help us better understand the protein family.
by Julia C. Oddo.
S.M.
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Agouri, Siham Rajab. "Genetic characterisation of MBL positive pseudomonas and Enterobacteriaceae." Thesis, Cardiff University, 2014. http://orca.cf.ac.uk/64515/.

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Silva, Elza Lima da. "Variantes no gene MBL2 codificador da Lectina Ligante de Manose (MBL): implicações na leishmaniose visceral humana." Universidade do Estado do Rio de Janeiro, 2013. http://www.bdtd.uerj.br/tde_busca/arquivo.php?codArquivo=6300.

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A leishmaniose visceral (LV) ou calazar é uma doença endêmica, crônica, grave e de alta letalidade se não tratada. Os estudos apontam a proteína Lectina Ligante de Manose (MBL), codificada pelo gene MBL2, como uma peça-chave na imunidade inata, dada a sua função no reconhecimento microbiano, na eliminação, inflamação e morte celular. Neste trabalho realizamos um estudo do tipo caso-controle que teve como objetivo investigar a associação entre variantes no gene MBL2 e a suscetibilidade à LV em indivíduos residentes em áreas endêmicas da Ilha de São Luís-MA. A amostra foi constituída por 322 indivíduos, sendo 161 casos com LV, não aparentados, de ambos os sexos, residentes em áreas endêmicas da doença na Ilha de São Luís e 161 controles saudáveis, não infectados e não aparentados da mesma região. A identificação dos casos de LV se deu por meio do contato constante com os principais hospitais e ambulatórios de referência para a doença na cidade. Também foram feitas buscas de pacientes com LV em ambiente domiciliar, a partir de registros da FUNASA-MA. A análise molecular consistiu na genotipagem de 6 variantes localizadas na região promotora [posições -550 (C>G), -221(G>C), +4(C>T)] e codificadora [códons 52 (C>T), 54 (G>A) e 57 (G>A)] do gene MBL2, através da reação em cadeia da polimerase e sequenciamento automático. A dosagem da proteína MBL no soro foi realizada pelo teste de ELISA. Verificamos que os fenótipos MBL dependem do conjunto de alelos presentes no gene MBL2, sendo nítido o efeito que as variantes defectivas causam nos níveis da proteína. Não encontramos diferença significativa entre casos e controles em relação à distribuição dos genótipos MBL2 e dos níveis séricos de MBL. As frequências alélicas das variantes exônicas na amostra total mostram que o alelo A é o mais comum (74,8%) e que os alelos defectivos (B, C e D) se encontram principalmente em heterozigose (36,6%), o que reforça a ideia de que alelos MBL2 defectivos são mantidos na população por conferirem vantagem seletiva aos heterozigotos. Em relação aos 3 principais polimorfismos existentes na região promotora, verificamos ser a variante -221G (Y) a mais frequente (88%) seguida de +4C (P) (73%) e de -550C (L) (67%). Identificamos oito haplótipos em MBL2 num total de 644 cromossomos avaliados, em 30 combinações diferentes, sendo HYPA e LYQA os mais frequentes e HYPD e HYPB os mais raros. Todos os portadores de combinações de haplótipos homozigotos para alelos defectivos apresentaram níveis séricos de MBL indetectáveis. Os genótipos LYQA/LYQA e HYPA/HYPA apresentaram as maiores concentrações médias de MBL no soro. A combinação entre SNPs no éxon 1 e na região promotora do gene MBL2 resulta em grande variação nas concentrações de MBL em indivíduos saudáveis. Consideramos que o conjunto de dados gerados é uma contribuição valiosa que poderá ser expandida para outros cenários.
Visceral leishmaniasis (VL), also known as kalazar, is an endemic, chronic, severe and highly lethal disease when not treated. Studies have shown that the protein Mannose-biding lectin (MBL), encoded by the gene MBL2, is the major player in innate immune system due its role in microbial recognition, elimination and inflammation as well as in the cell death. In the current work, we conducted a case-control study which aimed to investigate the association between variants in the gene MBL2 and the susceptibility to VL in individuals living in endemic areas of the São Luís - MA. 322 individuals participated in this study. Of these, 161 were VL cases being unrelated individuals of both sexes, and inhabitants from endemic areas of the disease in São Luís. The other 161 individuals were uninfected healthy controls, being unrelated and from the same region. The identification of VL cases occurred by visiting reference hospitals and clinics in the city. VL patients were identified in the household environment through the records of FUNASA-MA. Molecular analysis consisted in genotyping six variants located in the promoter region [positions -550 (C> G), -221 (G> C), +4 (C> T)] and coding region [codons 52 (C> T), 54 (G> A) and 57 (G> A)] of the MBL2 gene by polymerase chain reaction and automated DNA sequencing. The concentrations of MBL protein in the serum was performed by ELISA. We found that MBL phenotypes depend on the number of alleles present in the gene MBL2, being clear the consequence of the defective variants in the protein levels. There was no significant difference between cases and controls regarding the distribution of MBL2 genotypes and MBL serum levels. The allele frequencies of exon variants in the overall sample showed that the A allele is the most common (74.8%) and that the defective alleles (B, C and D) are mainly heterozygous (36.6%). This highlights the idea that defective MBL2 alleles are maintained in the population to confer selective advantage to heterozygotes. Concerning the three main existing polymorphisms in the promoter region, we noticed that the variant-221G (Y) is more frequent (88%) followed by +4 C (P) (73%) and 550C-(L) (67%) variants. We identified eight haplotypes in MBL2 in a total of 644 chromosomes evaluated in 30 different combinations, being the HYPA and LYQA the most frequent haplotypes and HYPD and HYPB the rarest ones. All carriers with combinations of homozygous haplotypes for defective alleles had undetectable serum levels of MBL. Genotypes LYQA / LYQA and HYPA / HYPA had the highest mean concentrations of MBL in the serum. Combination between SNPs in exon 1 and in the promoter region of the gene MBL2 results in a great variation of MBL concentrations in healthy individuals. We consider that the data set that was generated is a valuable contribution that can be expanded to others cenarios.
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CESARANO, CINZIA. "Citizen Science approaches for beach litter monitoring." Doctoral thesis, Università Politecnica delle Marche, 2022. https://hdl.handle.net/11566/305901.

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Questa tesi dal titolo "Approcci della scienza dei cittadini per il monitoraggio dei rifiuti da spiaggia" si concentra sui rifiuti marini delle spiagge (di seguito MBL). MBL rappresenta un enorme problema che riguarda le aree scientifiche, economiche e sociali. Durante il primo anno di dottorato è stata organizzata e realizzata un'attività pilota di citizen science per il monitoraggio dell'ambiente balneare con studenti delle scuole primarie e secondarie, utilizzando il protocollo MAC-Emerso. Le osservazioni raccolte sono state incluse nel database ufficiale MAC-Emerso. Durante il secondo anno, è stata completata un'analisi bibliometrica sul MBL e i risultati raggiunti sono stati organizzati per la pubblicazione in una rivista peer-reviewed. Inoltre, è stata effettuata un'analisi preliminare del database nazionale MAC-Emerso disponibile. Il terzo anno è stato dedicato alla compilazione di studi e programmi precedenti incentrati sul monitoraggio MBL e sulle campagne di bonifica lungo la costa mediterranea. Tutte le metodologie applicate fino ad oggi sono state analizzate e confrontate nel dettaglio per identificare i punti di forza e di debolezza dei protocolli attuali, il coinvolgimento dei cittadini e le lacune esistenti. La presente tesi è composta da otto capitoli e due articoli e si apre con un'introduzione generale che descrive MBL (Capitolo 1). Il capitolo 2 discute l'obiettivo generale della ricerca di dottorato e riassume gli articoli inclusi nella tesi di dottorato. Il capitolo 3 esamina in dettaglio la strategia marina, mentre il capitolo 4 si concentra sulla scienza dei cittadini e sul protocollo MAC-Emerso. Il capitolo 5 descrive i principali risultati raggiunti, inclusa l'attività pilota di citizen science organizzata e realizzata per il monitoraggio dell'ambiente balneare con gli studenti delle scuole primarie e secondarie che utilizzano il protocollo MAC-Emerso. Il capitolo 6 comprende la raccolta dei due articoli scientifici su MBL realizzati durante le attività di dottorato. Il primo paper (Cesarano et al., 2021) è stato pubblicato su Marine Pollution Bulletin (con ranking Q1), mentre il secondo paper è stato recentemente inviato alla stessa rivista. Il primo esplora la letteratura scientifica globale sull'MBL attraverso un'accurata analisi bibliometrica. Quest'ultimo presenta una revisione sistematica della letteratura corrente sul monitoraggio MBL lungo le coste del Mediterraneo. Insieme, forniscono una revisione completa delle conoscenze scientifiche sull'MBL nella regione mediterranea e offrono spunti interessanti per capire dove si trovano le lacune attuali e cosa sarebbe necessario per sviluppare un monitoraggio più efficiente su scala di bacino a sostegno dei nostri sforzi per affrontare il Sfida MBL. Infine, un'osservazione conclusiva dei risultati complessivi raggiunti nel presente studio è elaborata nel Capitolo 7. Segue una nota sugli altri prodotti non inclusi in questa tesi, ma eseguiti durante il mio periodo di dottorato. Quindi, un elenco di riferimento degli studi menzionati attraverso la tesi conclude questo documento.
This thesis entitled “Citizen Science approaches for beach litter monitoring” focuses on Marine Beach Litter (hereafter MBL). MBL represents a huge problem that concerns scientific, economic, and social areas. During the first year of my PhD, a pilot citizen science activity was organized and realized for monitoring beach environment with primary and secondary school students, using the MAC-Emerso protocol. The collected observations were included in the official MAC-Emerso database. During the second year, a bibliometric analysis on the MBL topic has been completed and the achieved results have been organized for publication in a peer-reviewed journal. Furthermore, a preliminary analysis of the available national MAC-Emerso database was carried out. The third year was devoted to compile previous studies and programs focusing on MBL monitoring and cleanup campaigns along the Mediterranean coastline. All the methodologies applied to date have been analysed and compared in detail to identify strengths and weaknesses of current protocols, citizen involvement, and existing gaps. The present thesis consists of eight chapters and two papers and opens with a general introduction describing MBL (Chapter 1). Chapter 2 discusses the overall aim of the PhD research, and summarizes the papers included in the PhD thesis. Chapter 3 examines in detail the Marine Strategy, while Chapter 4 focuses on Citizen Science and the MAC-Emerso protocol. Chapter 5 describes the main results achieved, including the pilot citizen science activity organized and realized for monitoring beach environment with primary and secondary school students using the MAC-Emerso protocol. Chapter 6 includes the collection of the two scientific papers on MBL realized during the PhD activities. The first paper (Cesarano et al., 2021) has been published in Marine Pollution Bulletin (with Q1 ranking), while the second paper has been recently submitted to the same journal. The former explores the global scientific literature on MBL through an accurate bibliometric analysis. The latter presents a systematic review of current literature concerning MBL monitoring along the Mediterranean coasts. Together, they do provide a comprehensive review of the scientific knowledge on MBL in the Mediterranean region and offer interesting insights to understand where current gaps lie, and what would be needed to develop a basin-scale more efficient monitoring in support of our efforts to tackle the MBL challenge. Finally, a concluding remark of the overall results achieved in the present study is elaborated in Chapter 7. A note about the other products not included in this thesis, but performed during my PhD period, follows. Then, a reference list of the studies mentioned through the thesis ends this document.
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Dzwonek, A. B. "The role of mannose binding lectin (MBL) in paediatric infection." Thesis, University College London (University of London), 2008. http://discovery.ucl.ac.uk/1444154/.

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Mannose-binding lectin (MBL) is a circulating pattern-recognition molecule that recognizes microbial carbohydrate motifs leading to complement activation and cell lysis. Mutations in MBL promoter and exon-1 result in reduced protein levels and in a number of studies appear to increase susceptibility to infection. This thesis explores the role of MBL in paediatric infection in two clinical settings. The effect of MBL deficiency on susceptibility and progression of HIV-1 infection was investigated in one hundred and twenty eight children, aged 2-16 years. MBL deficiency appeared to be less frequent in this population than in published series of Caucasian or African children. This may be due to selective survival of children with wild type MBL genotypes as patients with severe disease, as assessed by low CD4+T cell counts, were more likely to have MBL variant alleles. In support of this hypothesis, MBL deficiency was less frequent in children classified as long term non- progressors (LTNP-s). A second study explored the impact of MBL on susceptibility and severity of infection in preterm neonates. One hundred sixty six preterm neonates were genotyped for MBL mutations by polymerase chain reaction (PCR) and heteroduplex analyses. Serum MBL levels were measured by ELISA. Comparison of genotypes (A= wild type, 0=variant alleles) and protein levels between groups was performed using Chi-square, Mann-Whitney or Kruskal-Wallis test. Low MBL levels were observed in premature neonates, particularly in the first week of life (p=0.001). MBL deficiency was associated with an increased risk of sepsis in VLBW neonates (<1500g), (p=0.0T). The studies described in this thesis provide support for MBL having a role in susceptibility to and severity of infection in children.
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Chalmers, James Duncan. "Lectin pathway of complement and bacterial colonisation in bronchiectasis." Thesis, University of Edinburgh, 2014. http://hdl.handle.net/1842/33117.

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Bronchiectasis is a chronic inflammatory lung disease associated with failure of the normal mucociliary escalator, chronic bacterial colonisation of the airways, neutrophil mediated inflammation and a resulting clinical syndrome of respiratory infections, lung damage and symptoms such as cough, sputum production and shortness of breath. These are few effective treatments and the cause of bronchiectasis is unknown in the majority of patients. It is hypothesised that unrecognised immune defects may predispose to bronchiectasis or affect the severity of lung disease. Ficolin-2 is a circulating innate immune protein able to activate the lectin pathway of complement through interaction with mannose binding lectin associated serine protease-2. Through its structural and functional similarity to complement component C1q and mannose binding lectin, it is hypothesised that ficolin-2 may be involved in opsonophagocytosis of pathogens. A number of single nucleotide polymorphisms in the ficolin-2 gene have been described causing considerable variation in human ficolin-2 serum concentrations in healthy individuals. In this thesis, the role of the key lectin pathway components ficolin-2 and mannose binding lectin, are investigated in patients with bronchiectasis. We demonstrate a significant association between single nucleotide polymorphisms in the FCN2 gene and disease severity in bronchiectasis. Specifically, patients with low expressing FCN2 haplotypes have a higher frequency of chronic colonisation, colonisation with P. aeruginosa, more frequent exacerbations and worse health related quality of life. An association between MBL deficient genotypes and disease severity is also demonstrated suggesting an important role for the lectin pathway of complement in modifying disease severity in bronchiectasis. In-vitro studies identify that ficolin-2 is the major lectin pathway component responsible for complement activation on P. aeruginosa and that ficolin-2 binds to a wide range of clinically relevant pathogens. Neutrophils isolated from the sputum of patients with bronchiectasis showed significant alterations in surface receptor expression and function compared to peripheral blood neutrophils, with a novel effect of neutrophil elastase cleavage of CD88 contributing to reduced phagocytosis by airway neutrophils. Despite loss of phagocytic receptors from sputum neutrophils, opsonisation by ficolin-2/MASP-2 complexes still enhanced phagocytosis of P. aeruginosa by sputum neutrophils, suggesting that ficolin-2 may be relevant in the clearance of P. aeruginosa in the airway. In summary, ficolin-2 was found to be an important modifier of disease severity in bronchiectasis.
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Books on the topic "MBL"

1

Iseskog, Tommy. 10 år med MBL. Knivsta: Aktuell juridik, 1987.

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Burr, Gregory A. MBL-USA, Ottawa, Illinois. [Atlanta, Ga.?]: U.S. Dept. of Health and Human Services, Public Health Service, Centers for Disease Control and Prevention, National Institute for Occupational Safety and Health, 1995.

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Burr, Gregory A. MBL-USA, Ottawa, Illinois. [Atlanta, Ga.?]: U.S. Dept. of Health and Human Services, Public Health Service, Centers for Disease Control and Prevention, National Institute for Occupational Safety and Health, 1995.

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Burr, Gregory A. MBL-USA, Ottawa, Illinois. [Atlanta, Ga.?]: U.S. Dept. of Health and Human Services, Public Health Service, Centers for Disease Control and Prevention, National Institute for Occupational Safety and Health, 1995.

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Burr, Gregory A. MBL-USA, Ottawa, Illinois. [Atlanta, Ga.?]: U.S. Dept. of Health and Human Services, Public Health Service, Centers for Disease Control and Prevention, National Institute for Occupational Safety and Health, 1995.

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Burr, Gregory A. MBL-USA, Ottawa, Illinois. [Atlanta, Ga.?]: U.S. Dept. of Health and Human Services, Public Health Service, Centers for Disease Control and Prevention, National Institute for Occupational Safety and Health, 1995.

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National Institute for Occupational Safety and Health, ed. MBL-USA, Ottawa, Illinois. Atlanta, Ga.?]: U.S. Department of Health and Human Services, Public Health Service, Centers for Disease Control and Prevention, National Institute for Occupational Safety and Health, 1995.

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Oscar Vargas del Carpio Ribert. Las transformaciones del Movimiento Bolivia Libre (MBL) en el proceso domocrático. La Paz, Bolivia: Universidad Mayor de San Andrés, Facultad de Ciencias Sociales, Carrera de Sociología, Instituto de Investigaciones Sociológicas, 1998.

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Oscar Vargas del Carpio Ribert. Las transformaciones del Movimiento Bolivia Libre (MBL) en el proceso domocrático. La Paz, Bolivia: Universidad Mayor de San Andrés, Facultad de Ciencias Sociales, Carrera de Sociología, Instituto de Investigaciones Sociológicas, 1998.

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Guido, Heinrich, and Schandera Gunter 1940-, eds. MBL, Magdeburger biographisches Lexikon: 19. und 20. Jahrhundert : biographisches Lexikon für die Landeshauptstadt Magdeburg und die Landkreise Bördekreis, Jerichower Land, Ohrekreis und Schönebeck. Magdeburg: Scriptum, 2002.

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Book chapters on the topic "MBL"

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Inoué, Shinya. "Further at MBL." In Pathways of a Cell Biologist, 203–37. Singapore: Springer Singapore, 2016. http://dx.doi.org/10.1007/978-981-10-0947-1_5.

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Chiew, Shao-Hen, Leong-Chuan Kwek, and Chee-Kong Lee. "Exploring the Dynamics of Quantum Information in Many-Body Localised Systems with High Performance Computing." In Supercomputing Frontiers, 43–58. Cham: Springer International Publishing, 2022. http://dx.doi.org/10.1007/978-3-031-10419-0_4.

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Abstract Conventional many-body quantum systems thermalize under their own dynamics, losing information about their initial configurations to the environment. However, it is known that a strong disorder results in many-body localization (MBL). A closed quantum systems with MBL retains local information even in the presence of interactions. Here, we numerically study the propagation and scrambling of quantum information of a closed system in the MBL phase from an information theoretic perspective. By simulating the dynamics and equilibration of the temporal mutual information for long times, we see that it can distinguish between MBL and ergodic phases.
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Inoué, Shinya. "University of Pennsylvania, More on MBL." In Pathways of a Cell Biologist, 153–201. Singapore: Springer Singapore, 2016. http://dx.doi.org/10.1007/978-981-10-0947-1_4.

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Sassi, Elena, and Emilio Balzano. "Learning and Teaching Motion: MBL Approaches." In Microcomputer–Based Labs: Educational Research and Standards, 147–63. Berlin, Heidelberg: Springer Berlin Heidelberg, 1996. http://dx.doi.org/10.1007/978-3-642-61189-6_8.

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Gupta, Anita. "MBL Deficiency as Risk of Infection and Autoimmunity." In Animal Lectins: Form, Function and Clinical Applications, 933–53. Vienna: Springer Vienna, 2012. http://dx.doi.org/10.1007/978-3-7091-1065-2_42.

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Bernhard, Jonte. "Physics Learning and Microcomputer Based Laboratory (MBL) Learning Effects of Using MBL as a Technological and as a Cognitive Tool." In Science Education Research in the Knowledge-Based Society, 323–31. Dordrecht: Springer Netherlands, 2003. http://dx.doi.org/10.1007/978-94-017-0165-5_34.

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Kania, Per W., and Kurt Buchmann. "Complement Activation in Fish with Emphasis on MBL/MASP." In Principles of Fish Immunology, 279–300. Cham: Springer International Publishing, 2022. http://dx.doi.org/10.1007/978-3-030-85420-1_9.

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Heuer, Dieter. "Changing Misconceptions Through MBL—A Concept for Lab-Sessions." In Microcomputer–Based Labs: Educational Research and Standards, 271–79. Berlin, Heidelberg: Springer Berlin Heidelberg, 1996. http://dx.doi.org/10.1007/978-3-642-61189-6_16.

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Kojima, M., J. S. Presanis, and R. B. Sim. "The Mannose-Binding Lectin (MBL) Route for Activation of Complement." In Advances in Experimental Medicine and Biology, 229–50. Boston, MA: Springer US, 2003. http://dx.doi.org/10.1007/978-1-4615-0065-0_15.

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Juuti, Kalle, Jari Lavonen, and Veijo Meisalo. "Phenomenographical Approach to Design for a Hypertext Teacher’s Guide to MBL." In Science Education Research in the Knowledge-Based Society, 333–41. Dordrecht: Springer Netherlands, 2003. http://dx.doi.org/10.1007/978-94-017-0165-5_35.

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Conference papers on the topic "MBL"

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Skorge, TD, TL Eagan, PS Aukrust, PS Bakke, JK Damas, T. Ueland, JA Hardie, and TE Mollnes. "MBL Deficiency and COPD." In American Thoracic Society 2009 International Conference, May 15-20, 2009 • San Diego, California. American Thoracic Society, 2009. http://dx.doi.org/10.1164/ajrccm-conference.2009.179.1_meetingabstracts.a3956.

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Niedderer, Hans, and Horst Schecker. "Laboratory tasks with MBL and MBS for prospective high school teachers." In The changing role of physics departments in modern universities. AIP, 1997. http://dx.doi.org/10.1063/1.53117.

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Yang, Wenxiang, Dezun Dong, Jingyue Zhao, and Cunlu Li. "MBL: A Multi-stage Bufferless High-radix Router." In 2016 IEEE International Conference on Cluster Computing (CLUSTER). IEEE, 2016. http://dx.doi.org/10.1109/cluster.2016.101.

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Kvittem, Marit, and Ludvik Kjosås Bergmann. "The Effect of Mean Tension on Fatigue of Mooring Chain for a 12 MW Semi-Submersible Wind Turbine." In ASME 2022 4th International Offshore Wind Technical Conference. American Society of Mechanical Engineers, 2022. http://dx.doi.org/10.1115/iowtc2022-94183.

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Abstract Recently published studies have documented a significant mean load effect on fatigue capacity for offshore mooring chains, showing that a reduction of mean loads gives an increase in fatigue life. Standard design practice has been to base S-N fatigue design curves on tests carried out at 20% of the chain minimum breaking load (MBL). These curves are then used to compute damage for all tension cycles, regardless of their actual mean value. This paper investigates the mean load dependency in mooring chains for the INO WINDMOOR 12 MW floating offshore wind turbine by describing the mean load tension associated with each stress cycle in two different ways: The average of the maximum and minimum load in each cycle (cycle mean) and half-hour mean load. A parametrized S-N curve design approach developed by Fernández et al. was used to account for the mean tension. With both methods for accounting for mean stress, the mean tension was below 20% MBL, for the least extreme load conditions. More extreme load cases caused half-hour means above 20% of MBL, and single cycle mean tensions were far beyond the 20% limit, and contributed with large fatigue damage. This caused some difference between the methods. Compared to the DNVGL-OS-E301 S-N curve, a significant reduction in fatigue damage was seen for the mooring lines least affected by the extreme conditions (leeward). However, mean tensions beyond 20% of MBL in the windward line contributed to larger fatigue damage in extreme cases, and ended up with a total accumulated damage similar to the design curve base case. The validity range of the method was 7%–20%, and many observations were outside of this range.
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Soti, A., O. Gorlanova, L. Müller, JM Kurz, J. Usemann, LJ Schapbach, M. Kabesch, U. Frey, P. Latzin, and O. Fuchs. "Gemeinsame Effekte pränataler Rauchexposition sowie von Polymorphismen im MBL2-Gen auf Mannose-bindendes Lectin (MBL) im Nabelschnurblut." In 60. Kongress der Deutschen Gesellschaft für Pneumologie und Beatmungsmedizin e. V. Georg Thieme Verlag KG, 2019. http://dx.doi.org/10.1055/s-0039-1678151.

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Gabrielsen, Øystein, Kjell Larsen, Oddgeir Dalane, Hans B. Lie, and Svein-Arne Reinholdtsen. "Mean Load Impact on Mooring Chain Fatigue Capacity: Lessons Learned From Full Scale Fatigue Testing of Used Chains." In ASME 2019 38th International Conference on Ocean, Offshore and Arctic Engineering. American Society of Mechanical Engineers, 2019. http://dx.doi.org/10.1115/omae2019-95083.

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Abstract Fatigue of mooring chain is for many floating offshore installations a limiting factor in design. With aging installations and the need for field life extension beyond the original design life, questions on mooring chain endurance are raised. Current SN curves utilized in fatigue limit state (FLS) calculation are based on full scale testing of new chain, performed at a high mean load level (20% of the chains minimum breaking load (MBL)). The high mean load level in the tests do not correspond to the conditions for many chains in operation, as mean load in fatigue relevant seastates are often significantly less than mean load used in the new chain fatigue tests. Mooring chains in operation also experience different degree of corrosion, both general corrosion and pitting. Surface roughness and corrosion pits contribute to crack initiations, and thus reduce fatigue capacity. Fatigue tests with new chain condition cannot be assumed representative for corroded chains. As part of mooring integrity programs, Equinor has been replacing mooring chains since year 2000. To assess actual fatigue capacity, many chain segments have been full scale fatigue tested. First tests started in 2011, and the tests cover different degrees of corrosion. The tests have been performed at typical mean load levels relevant for operation of the installations, which for most cases are less than 20%MBL. From these tests it is observed that fatigue capacity in some cases are better than expected for new chain, even for chain segments with significant corrosion. Fatigue test results show a large effect of the mean load. For test cases with significant corrosion and high mean load (20%MBL), a significant reduction in fatigue capacity compared to new chains is found. This paper presents some of the fatigue test results on used chain, highlighting the effect of the mean load for the given chain conditions. Effect of corrosion at mean load of 20%MBL is also included. The paper discusses some of the underlaying causes for the mean load dependency.
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Rossi, Ronaldo Rosa. "A Review of Fatigue Curves for Mooring Lines." In ASME 2005 24th International Conference on Offshore Mechanics and Arctic Engineering. ASMEDC, 2005. http://dx.doi.org/10.1115/omae2005-67583.

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For mooring chains of offshore floating production units, API (American Petroleum Institute) recommends the use of its TxN fatigue curve considering the MBL (Minimum Breaking Load) of an ORQ (Oil Rig Quality) chain even if the chain has a higher grade. This curve has been used in mooring system design of offshore floating production units since the draft edition of API Recommended Practice for Design, Analysis and Maintenance of Catenary Mooring for Floating Production Systems in May 89 and several fatigue tests have been done by petroleum industries, chain manufacturers and research centers. Those fatigue tests show that the use of the MBL of an ORQ chain for higher grades is a conservative assumption. This paper will present an overview of the fatigue curves of materials for mooring lines: stud and studless chains, steel wire ropes and polyester fiber ropes. This overview is based on recent tests, rules and published papers.
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Jin, Zhaoyu, and Xin Wang. "The Effects of Nonproportional Loading on the Elastic-Plastic Crack-Fronts Fields." In ASME 2016 Pressure Vessels and Piping Conference. American Society of Mechanical Engineers, 2016. http://dx.doi.org/10.1115/pvp2016-63851.

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In this paper, the loading path effect on the elastic-plastic crack-front stress field in a thin plate is investigated. There different loading sequences include one proportional loading and two non-proportional loading paths are applied to the 3-D modified boundary layer (MBL) model under small-scale yielding conditions. For the same external displacement field applied at the outer boundary of the 3-D MBL model, the mode I K field and T-stress field combined as the different loading path is applied to investigate the influence of the nonproportional loading. The results show that for either the compressive or tensional T-stress, the loading path which applied K field followed by T field generates the lower crack-tip constraint. There is only slightly difference between the proportional loading path and the T-stress field following by K field loading path. The results show that it is very important to include the load sequence effects in fracture analysis when dealing with nonproportional loading conditions.
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Serban, K. A., A. Mikosz, D. Cao, N. Egersdorf, H. Steichen, R. J. Mason, J. P. Bridges, and I. Petrache. "Mannose Binding Lectin (MBL) and MBL Associated Serine Protease-2 (MASP-2) Amplify SARS-CoV-2 Spike Protein Uptake and Epithelial Cell Injury During Cigarette Smoke Exposure." In American Thoracic Society 2021 International Conference, May 14-19, 2021 - San Diego, CA. American Thoracic Society, 2021. http://dx.doi.org/10.1164/ajrccm-conference.2021.203.1_meetingabstracts.a4166.

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Isawa, Miki, Maki Tanaka, Hideyuki Kazumi, Chie Shishido, Akira Hamamatsu, Norio Hasegawa, Peter De Bisschop, David Laidler, Philippe Leray, and Shaunee Cheng. "Verification and extension of the MBL technique for photo resist pattern shape measurement." In SPIE Advanced Lithography, edited by Christopher J. Raymond. SPIE, 2011. http://dx.doi.org/10.1117/12.878960.

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Reports on the topic "MBL"

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Shirer, Hampton N., and George S. Young. Boundary Layer Coherent Structures (MBL ARI) and ASSERT Supplement, CY 1993 Report. Fort Belvoir, VA: Defense Technical Information Center, January 1993. http://dx.doi.org/10.21236/ada275007.

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Wood, R. Clouds, Aerosol, and Precipitation in the Marine Boundary Layer (CAP-MBL) Final Campaign Report. Office of Scientific and Technical Information (OSTI), January 2016. http://dx.doi.org/10.2172/1236497.

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CALS TEST NETWORK WRIGHT-PATTERSON AFB OH. Technical Publication T 0 12R2-2ARC2O8-112 Using: O'Neil and Associates, Incorporate Date Supporting: ESC/MSL MILSTAR Program MIL-D-28OOOA (IGES) MIL-M-28001A (SGML) MIL-R-28002A (Raster) MIL-D-28003 (CGM) Quick Short Test Report. Fort Belvoir, VA: Defense Technical Information Center, April 1994. http://dx.doi.org/10.21236/ada312957.

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Lammers, Gary, and Mel Lammers. Technical Publication Transfer Using: O'Neil and Associates, Inc. Data Supporting: ESC/MSL MILSTAR Program TO 12R2-2A-1664 (Contract Number F19628-89-C-0131). MIL-D-28000A (IGES), MIL-M-28001A (SGML), MIL-R-28002A (Raster). Quick Short Test Report. Fort Belvoir, VA: Defense Technical Information Center, May 1994. http://dx.doi.org/10.21236/ada312992.

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Bessee, Gary B. DoD Coalescer Qualifications to MIL-F-52308F and MIL-F-8901E. Fort Belvoir, VA: Defense Technical Information Center, December 2007. http://dx.doi.org/10.21236/ada476824.

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CALS TEST NETWORK WRIGHT-PATTERSON AFB OH. Technical Publication Transfer Using: Gateway Conversion Technology's Data, MIL-STD-1840A, MIL-M-28001B (SGML), MIL-D-28003 (CGM). Fort Belvoir, VA: Defense Technical Information Center, September 1994. http://dx.doi.org/10.21236/ada309289.

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Lammers, Gary, and Mel Lammers. Conversion of MIL-STD-ATOS to MIL-M-28001 Tag Set Using: AGMC/MLEP JCALS Test Site's Data TO 33K3-4-313-1. MIL-STD-1840A, MIL-M-2800lA (SGML), MIL-R-28002A (Raster), MIL-D-28003 (CGM). Quick Short Test Report. Fort Belvoir, VA: Defense Technical Information Center, April 1994. http://dx.doi.org/10.21236/ada312865.

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CALS TEST NETWORK WRIGHT-PATTERSON AFB OH. Technical Publication Transfer Using: Northrop Corporation's Data MIL-D-28OOOA (IGES), MIL-M-280O1A (SGML), MIL-R-28OO2A (Raster), MIL-D-280O3 (CGM) Quick Short Test Report. Fort Belvoir, VA: Defense Technical Information Center, May 1993. http://dx.doi.org/10.21236/ada312311.

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CALS TEST NETWORK WRIGHT-PATTERSON AFB OH. Technical Publication Transfer Using: Northrop Corporation's Data MIL-D-28OOA (IGES), MIL-M-28OO1A (SGML), MIL-R-28OO2A (Raster), MIL-D-28OO3 (CGM) Quick Short Test Report. Fort Belvoir, VA: Defense Technical Information Center, March 1993. http://dx.doi.org/10.21236/ada312312.

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CALS TEST NETWORK WRIGHT-PATTERSON AFB OH. Technical Publication Transfer Using: Northrop Corporation's Data, MIL-D-28000A (IGES), MIL-M-28001A (SGML), MIL-R-28002A (Raster), MIL-D-28003 (CGM). Quick Short Test Report. Fort Belvoir, VA: Defense Technical Information Center, April 1993. http://dx.doi.org/10.21236/ada312439.

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