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Journal articles on the topic 'MC3D'

Author: Grafiati

Published: 8 June 2024

Last updated: 31 July 2025

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1

Green, Thomas D., David C. Montefiori, and Ted M. Ross. "Enhancement of Antibodies to the Human Immunodeficiency Virus Type 1 Envelope by Using the Molecular Adjuvant C3d." Journal of Virology 77, no. 3 (2003): 2046–55. http://dx.doi.org/10.1128/jvi.77.3.2046-2055.2003.

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ABSTRACT DNA vaccines expressing the envelope (Env) protein of the human immunodeficiency virus have been relatively ineffective at generating high-titer, long-lasting, neutralizing antibodies in a variety of animal models. In this study, the murine and human homologues of the complement component, C3d, were used in a DNA vaccine to enhance the titers of antibody to Env. Initially, plasmids expressing a secreted form of Env (sgp120) fused to one, two, or three copies of the murine homologue of C3d (mC3d) were constructed. Mice were inoculated with four vaccinations of DNA or two DNA vaccinatio

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Jian, Feng Xu, Pooya Hadian, Stephen Doyle, Simon Molyneux, and Hongfeng Wu. "Major geological surfaces of the Exmouth Plateau from the new Broadband PreSDM reprocessed 3D seismic data with full waveform inversion." APPEA Journal 62, no. 2 (2022): S442—S448. http://dx.doi.org/10.1071/aj21049.

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The Barrow Sub-basin and Exmouth Plateau, of Australia’s North West Shelf, contain Australia’s largest gas reserves, underpinning the three major LNG facilities, including Gorgon, Wheatstone and Pluto. In addition, there remains significant near-field exploration potential such as the Sasanof prospect. While there is full 3D seismic coverage in the basin, the existing 3D surveys are of different vintages covering only parts of the basin with diverse acquisition and processing parameters. Multi-Client Resources has produced an extensive 3D seismic reprocessing project (BEX-MC3D) incorporating 2

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Bower, Joseph F., Xinzhen Yang, Joseph Sodroski, and Ted M. Ross. "Elicitation of Neutralizing Antibodies with DNA Vaccines Expressing Soluble Stabilized Human Immunodeficiency Virus Type 1 Envelope Glycoprotein Trimers Conjugated to C3d." Journal of Virology 78, no. 9 (2004): 4710–19. http://dx.doi.org/10.1128/jvi.78.9.4710-4719.2004.

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ABSTRACT DNA vaccines expressing the envelope (Env) of human immunodeficiency virus type 1 (HIV-1) have been relatively ineffective at generating high-titer, long-lasting immune responses. Oligomeric or trimeric (gp140) forms of Env that more closely mimic the native proteins on the virion are often more effective immunogens than monomeric (gp120) envelopes. In this study, several forms of Env constructed from the HIV-1 isolate YU-2 (HIV-1YU-2) were tested for their immunogenic potential: a trimeric form of uncleaved (−) Env stabilized with a synthetic trimer motif isolated from the fibritin (

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Wolf, S. "MC3D–3D continuum radiative transfer, Version 2." Computer Physics Communications 150, no. 2 (2003): 99–115. http://dx.doi.org/10.1016/s0010-4655(02)00675-6.

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Molyneux, Simon, and Stephen Doyle. "Salt in the Vulcan sub-basin, NW Australia: observations from high-quality 3D seismic data and implications for palaeogeography." APPEA Journal 61, no. 2 (2021): 684. http://dx.doi.org/10.1071/aj20068.

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The Vulcan sub-basin is one of the few places in Australia where tectonic features (i.e. diapirs) associated with a mobile substrate can be found. In this presentation one of these features, the Paqualin diapir, and its environs will be described and discussed using the new regional NOVAR MC3D prestack depth migrated seismic dataset. The extent of the NOVAR MC3D seismic dataset makes it possible, for the first time, to integrate the observation of c. 600m of interbedded halite and anhydrite in the Paqualin-1 well, local fault geometries indicative of the movement of a mobile layer and regional

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Raverdy, Bruno, Renaud Meignen, Libuse Piar, Stephane Picchi, and Tanguy Janin. "Capabilities of MC3D to investigate the coolability of corium debris beds." Nuclear Engineering and Design 319 (August 2017): 48–60. http://dx.doi.org/10.1016/j.nucengdes.2017.04.005.

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Berthoud, G. "Models and validation of particulate debris coolability with the code MC3D-REPO." Nuclear Engineering and Design 236, no. 19-21 (2006): 2135–43. http://dx.doi.org/10.1016/j.nucengdes.2006.03.060.

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Kokalj, Janez, Mitja Uršič, Matjaž Leskovar, Libuse Piar, and Renaud Meignen. "Modelling of debris bed reflooding in PEARL experimental facility with MC3D code." Nuclear Engineering and Design 330 (April 2018): 450–62. http://dx.doi.org/10.1016/j.nucengdes.2018.02.016.

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Meignen, Renaud, and Tanguy Janin. "On the Analysis and Evaluation of Direct Containment Heating with the Multidimensional Multiphase Flow Code MC3D." Science and Technology of Nuclear Installations 2010 (2010): 1–13. http://dx.doi.org/10.1155/2010/289792.

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In the course of a postulated severe accident in an NPP, Direct Containment Heating (DCH) may occur after an eventual failure of the vessel. DCH is related to dynamical, thermal, and chemical phenomena involved by the eventual fine fragmentation and dispersal of the corium melt out of the vessel pit. It may threaten the integrity of the containment by pressurization of its atmosphere. Several simplified modellings have been proposed in the past but they require a very strong fitting which renders any extrapolation regarding geometry, material, and scales rather doubtful. With the development o

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Meilland, Antony, Sameer Kanaan, Marcelo Borges Fernandes, et al. "Resolving the dusty circumstellar environment of the A[e] supergiant HD 62623 with the VLTI/MIDI." Proceedings of the International Astronomical Union 6, S272 (2010): 406–7. http://dx.doi.org/10.1017/s1743921311010945.

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AbstractHD 62623 is one of the very few A-type supergiants showing the B[e] phenomenon. We studied the geometry of its circumstellar envelope in the mid-infrared using the VLTI/MIDI instrument. Using the radiative transfer code MC3D, we managed to model it as a dusty disk with an inner radius of 3.85 AU, an inclination angle of 60°, and a mass of 2 × 10−7M⊙. It is the first time that the dusty disk inner rim of a supergiant star exhibiting the B[e] phenomenon is significantly constrained. The inner gaseous envelope likely contributes up to 20% to the total N band flux and acts like a reprocess

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Musa, Hassan-Hussein, Wei-Juan Zhang, Jing Lv, et al. "The molecular adjuvant mC3d enhances the immunogenicity of FimA from type I fimbriae of Salmonella enterica serovar Enteritidis." Journal of Microbiology, Immunology and Infection 47, no. 1 (2014): 57–62. http://dx.doi.org/10.1016/j.jmii.2012.11.004.

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Boulard, P., J.-C. Jaboulay, J.-M. Martinez, and A. Zoia. "CONTRIBUTION OF THERMAL-HYDRAULICS SIMULATION TO CRITICALITY ANALYSIS OF A DEBRIS BED NUMERICAL MOCK-UP." EPJ Web of Conferences 247 (2021): 06010. http://dx.doi.org/10.1051/epjconf/202124706010.

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In this work, we evaluate the impact of simulating the thermal-hydraulics feedback in criticality risk assessment in a benchmark configuration corresponding to a simplified debris bed. We have recently discussed the coupling of the multi-phase thermal-hydraulics code MC3D with a reactivity evaluation scheme based on multi-point kinetics, which paves the way towards the assessment of the system behavior in terms of energy release. In this work, we analyze the system reactivity as a function of the thermal-hydraulics state of the system. For our investigation, we have considered a simplified cyl

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Uršič, Mitja, and Matjaž Leskovar. "Analysis of TROI-13 Steam Explosion Experiment." Science and Technology of Nuclear Installations 2008 (2008): 1–9. http://dx.doi.org/10.1155/2008/852047.

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The prediction of steam explosion inducing loads in nuclear power plants must be based on results of experimental research programmes and on simulations using validated fuel-coolant interaction codes. In this work, the TROI-13 steam explosion experiment was analysed with the fuel-coolant interaction MC3D computer code. The TROI-13 experiment is one of several experiments performed in the TROI research program and resulted in a spontaneous steam explosion using corium melt. First, the TROI-13 premixing simulations were performed to determine the initial conditions for the steam explosion simula

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Silva-Gonzalez, Patricio, and Jarrad Grahame. "High-quality data from the Eendracht MC3D seismic survey gives insight about the hydrocarbon potential of the Carnarvon Basin." APPEA Journal 53, no. 2 (2013): 486. http://dx.doi.org/10.1071/aj12097.

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The Eendracht 3D multi-client seismic survey covers an area of about 8,000 km2. It is located in the Carnarvon Basin, one of Australia’s most hydrocarbons-prolific basins. The basin is filled with thick Paleozoic, Mesozoic, and Cenozoic sedimentary successions, deposited during multiple phases of extension and following the breakup of Gondwana. The most prominent structural trend is northeast—southwest with basins and sub-basins aligned as a consequence of the rifting event, which occurred during Jurassic to Early Cretaceous. Recent discoveries like Ragnar–1 and Tallaganda–1 show a working pet

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Paten, Tom. "The prospectivity of the Late Triassic intervals in the outboard Exmouth Plateau, Western Australia." APPEA Journal 60, no. 2 (2020): 742. http://dx.doi.org/10.1071/aj19173.

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The Exmouth Plateau is a deep-water plateau on the Australian continental margin underlain by 10–15 km of flat-lying, tilted and block-faulted Paleozoic–Mesozoic sedimentary rocks, which were deposited predominantly during periods of extension before continental break-up commenced in the middle Jurassic. The recent acquisition of the Mawson MC3D broadband seismic survey provides a modern, high-quality dataset located ~230 km to the north-west of Dampier, in the outboard Exmouth Plateau, in a relatively under-explored portion of the Northern Carnarvon Basin. The Late Triassic Mungaroo Formation

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Lu, Hao, Yunpeng Zhang, Guoqing Wang, Qing Lian, Dalong Du, and Ying-Cong Chen. "Towards Generalizable Multi-Camera 3D Object Detection via Perspective Rendering." Proceedings of the AAAI Conference on Artificial Intelligence 39, no. 6 (2025): 5811–19. https://doi.org/10.1609/aaai.v39i6.32620.

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Detecting and localizing objects in 3D space using multiple cameras, known as Multi-Camera 3D Object Detection (MC3D-Det), has gained prominence with the advent of bird's-eye view (BEV) approaches. However, these methods often struggle with the serious domain gaps caused by various viewpoints and environments between the training and testing domains. To address this challenge, we propose a novel framework that aligns 3D detection with 2D camera plane results by perspective rendering, thus achieving consistent and accurate results when facing serious domain shifts. Our approach consists of two

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Yan, H., M. M. El Gomati, D. P. Chu, M. G. Dowsett, M. Prutton, and D. K. Wilkinson. "Mc3D: A three-dimensional Monte Carlo system simulating image contrast in surface analytical scanning electron microscopy I-Object-oriented software design and tests." Scanning 20, no. 6 (2006): 465–84. http://dx.doi.org/10.1002/sca.1998.4950200607.

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Parker, Scott L., and Matthew J. McGirt. "Determination of the Minimum Improvement in Pain, Disability, and Health State Associated With Cost-Effectiveness." Neurosurgery 71, no. 6 (2012): 1149–55. http://dx.doi.org/10.1227/neu.0b013e318271ebde.

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ABSTRACT BACKGROUND: Minimum clinical important difference (MCID) has been adopted as the smallest improvement in patient-reported outcome needed to achieve a level of improvement thought to be meaningful to patients. OBJECTIVE: To use a common MCID calculation method with a cost-utility threshold anchor to introduce the concept of minimum cost-effective difference (MCED). METHODS: Forty-five patients undergoing transforaminal lumbar interbody fusion for degenerative spondylolisthesis were included. Outcome questionnaires were administered before and 2 years after surgery. Total cost per quali

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Yoon, Jung A., Mun Jang, Jai Won Chang, and Eun Kyoung Lee. "Minimal Change in Nephrotic Syndrome Associated with Mixed Connective Tissue Disease." Korean Journal of Medicine 95, no. 6 (2020): 409–12. http://dx.doi.org/10.3904/kjm.2020.95.6.409.

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Mixed connective tissue disease (MCTD) is a rheumatologic disorder that has combined features of systemic lupus erythematosus, systemic sclerosis, and rheumatoid arthritis with the anti-U1 ribonucleoprotein (RNP) antibody. Although renal involvement is not included in any of the diagnostic criteria, it has been observed in 20% of MCTD patients. The most common renal disease is immune complex nephropathy, histologically classified as membranous glomerulonephritis, but minimal change disease (MCD) is very rare and has only been reported once previously. A previously healthy 33-year-old woman pre

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Bunch, Mark, Ric Daniel, Mark Lawrence, et al. "Multi-scale characterisation of the Paaratte Formation, Otway Basin, for CO2 injection and storage." APPEA Journal 52, no. 2 (2012): 664. http://dx.doi.org/10.1071/aj11078.

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A resurgent interest in the gas potential of the Gulf of Papua has been enhanced by the recent announcement of developing new LNG facilities in Port Moresby. Petroleum Geo-Services (PGS) has recently acquired a 6,000-km2Multi-Client 3D (MC3D) survey in the gulf. Although most of the discoveries in PNG are from the highland areas, the gulf is a proven hydrocarbon province with gas/condensate accumulations previously discovered in several reef build-ups. It is thought that sediments from the Papuan Fold Belt produced clastic dominated deltas in the Gulf area. Although this play is untested offsh

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Harrington, Amanda, Cyrille Reiser, Bob Burmaz, and Rod Reed. "Amplitude-versus-offset (AVO) screening in frontier basins: an example from the Gulf of Papua, Papua New Guinea." APPEA Journal 52, no. 2 (2012): 701. http://dx.doi.org/10.1071/aj11115.

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A resurgent interest in the gas potential of the Gulf of Papua has been enhanced by the recent announcement of developing new LNG facilities in Port Moresby. Petroleum Geo-Services (PGS) has recently acquired a 6,000-km2 Multi-Client 3D (MC3D) survey in the gulf. Although most of the discoveries in PNG are from the highland areas, the gulf is a proven hydrocarbon province with gas/condensate accumulations previously discovered in several reef build-ups. It is thought that sediments from the Papuan Fold Belt produced clastic dominated deltas in the Gulf area. Although this play is untested offs

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22

Patruno, Rosa, Ilaria Marech, Nicola Zizzo, et al. "C-Kit Expression, Angiogenesis, and Grading in Canine Mast Cell Tumour: A Unique Model to Study C-Kit Driven Human Malignancies." BioMed Research International 2014 (2014): 1–8. http://dx.doi.org/10.1155/2014/730246.

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Canine cutaneous mast cell tumour (CMCT) is a c-Kit driven tumour sharing similar c-Kit aberrations found in human gastrointestinal stromal tumour. CMCT is classified into three forms: well- (G1), intermediately (G2) (more benign diseases), and poorly (G3) differentiated (malignant) forms. We assess a correlation between c-Kit status, grading, and angiogenesis in CMCTs to explore their potential significance in humans. C-Kit receptor (c-KitR) expression, microvascular density (MVD), and mast cell granulated and degranulated status density (MCGD and MCDD, resp.) were analyzed in 97 CMCTs, by me

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Abouyahya, I., S. Liem, Z. Amoura, et al. "AB0675 Health related quality of life in patients with mixed connective tissue disease: A comparison with matched systemic sclerosis patients." Annals of the Rheumatic Diseases 81, Suppl 1 (2022): 1465.2–1465. http://dx.doi.org/10.1136/annrheumdis-2022-eular.2359.

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BackgroundMixed connective tissue disease (MCTD) is a systemic auto-immune disorder, being probably the least common among the connective tissue diseases. Symptoms can be severe and could affect health-related quality of life (HRQoL). Identification of the burden of MCTD patients is of key importance to provide appropriate pharmacological and non-pharmacological care. No reports on HRQoL have been published in adult patients with MCTD.ObjectivesTo perform an explorative study to evaluate HRQoL and its main determinants in MCTD patients, and compare HRQoL between MCTD and matched systemic scler

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Bianco, Lucas, James May, and Alan Nasypany. "Novel Approach to Treating Acute Hamstring Injury- Effects of Primal Reflex Release Technique." Clinical Practice in Athletic Training 2, no. 1 (2019): 19–31. http://dx.doi.org/10.31622/2019/0001.5.

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Hamstring injuries have an occurrence rate of 3.05 per 1000 athlete exposures in intercollegiate athletics. Current clinical practice recommendations for rehabilitation of hamstring injuries are based on pathoanatomical muscle tissue healing timeframes. The purpose of this study was to examine the effects of modulating the nervous system with Primal Reflex Release Technique (PRRT) in patients clinically diagnosed with functional neuromuscular hamstring muscle-related disorder (FNHD). In this a priori case series , PRRT was utilized in four patients participating in intercollegiate, National Co

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Nantavithya, Chonnipa, Kitwadee Saksornchai, Puntiwa Oonsiri, and Kanjana Shotelersuk. "Dosimetric study of three-dimensional conformal radiotherapy, electronic compensator technique, intensity-modulated radiation therapy and volumetric-modulated arc therapy in whole breast irradiation." Journal of Radiotherapy in Practice 16, no. 4 (2017): 431–43. http://dx.doi.org/10.1017/s1460396917000243.

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AbstractBackgroundWhole breast irradiation is an essential treatment after breast-conserving surgery (BCS). However, there are some adverse effects from inhomogeneity and dose to adjacent normal tissues.ObjectiveAim of this study was to compare dosimetry among standard technique, three-dimensional conformal radiotherapy (3D-CRT), and advanced techniques, electronic compensator (ECOMP), inverse intensity-modulated radiation therapy (IMRT) and volumetric-modulated arc therapy (VMAT).MethodsWhole breast irradiation treatment plans of patients who had underwent BCS and whole breast irradiation wer

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Stauff, Anna, Ellen Schneider, and Frank Heckel. "2-MCPD, 3-MCPD and fatty acid esters of 2-MCPD, 3-MCPD and glycidol in fine bakery wares." European Food Research and Technology 246, no. 10 (2020): 1945–53. http://dx.doi.org/10.1007/s00217-020-03546-4.

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in ’t Veld, C. J. "MCAD-deficiëntie." Bijblijven 32, no. 8-9 (2016): 533–34. http://dx.doi.org/10.1007/s12414-016-0180-z.

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Vinayasree., C., Naidu. K. Mohan, E. Muralinath., et al. "Symptoms of Classical MCAD Deficiency, Variant MCAD Deficiency as well as Silent Mcad Deficiency, Diagnosis of MCAD Deficiency, Differential Diagnosis of MCAD Deficiency and Treatment as well as Management of MCAD Deficiency." Research and Reviews: Neonatal and Pediatric Nursing 1, no. 2 (2023): 5–12. https://doi.org/10.5281/zenodo.8163023.

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<em>Medium - chain acetyl - CoA dehydrogenase (MCAD) deficiency ia a rare inherited metabolic disorder that shows its influence on the bodys capability to breakdown fatty acids for energy. The symptoms of classical MCAD deficiency typically manifest especially during infancy or early childhood. Variant MCAD deficiency is happened by mutations in the ACADM gene. Symptoms of variant MCAD deficiency are hypoglycemia, vomiting, lethargy, encephalopathy and liver dysfunction. Silent MCAD deficiency is also known as silent medium - chain acyl CoA dehydrogenase deficiency. Symptoms of silent MCAD def

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Chong, C. L. G., Faizah Othman, and Farida Hussan. "Vascular Protective Effects of Morinda citrifolia Leaf Extract on Postmenopausal Rats Fed with Thermoxidized Palm Oil Diet: Evidence at Microscopic Level." International Journal of Vascular Medicine 2018 (September 5, 2018): 1–10. http://dx.doi.org/10.1155/2018/6317434.

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Atherosclerosis is now well understood as an inflammatory disease instead of lipid storage disorder; however, the conventional treatment is not targeted on treating the inflammation. Morinda citrifolia L. (Rubiaceae) leaf or noni leaf, which is a medicinal food (ulam) used in Traditional Malay Medicine to prevent chronic diseases, may have the potential to be formulated into a functional antiatherosclerotic agent. This study aimed to investigate the effectiveness of Morinda citrifolia leaf extract (MCLE) treatment at histological and ultrastructural level, comparing it with Simvastatin. Thirty

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Vařák, Petr, Martin Leich, Michal Kamrádek та ін. "Nanoparticle doping and molten-core methods towards highly thulium-doped silica fibers for 0.79 μm-pumped 2 μm fiber lasers – a fluorescence lifetime study". Journal of Luminescence 25 (8 серпня 2024): 120835. https://doi.org/10.1016/j.jlumin.2024.120835.

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We study the fluorescence lifetime of Thulium-doped silica fibers for efficient laser operation in the 2 μm “eye-safe” wavelength range pumped by 0.79 μm radiation. A large set of optical fibers prepared by Modified Chemical Vapor Deposition combined with solution doping or nanoparticle doping, and Molten-core method is investigated in terms of fluorescence lifetimes of the 3F4 and 3H4 excited levels, which contain information about the Tm3+ ion environment, the rate of unwanted processes, such as concentration quenching or multiphonon relaxation, as well as th

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MIKULÍKOVÁ, Renata, Zdeněk SVOBODA, Karolína BENEŠOVÁ, and Sylvie BĚLÁKOVÁ. "3-MCPD Process Contaminant in Malt." Kvasny Prumysl 64, no. 1 (2018): 6–9. http://dx.doi.org/10.18832/kp201802.

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Haustein, Uwe-Frithjof. "MCTD - Mixed Connective Tissue Disease. MCTD - Mixed Connective Tissue Disease." Journal der Deutschen Dermatologischen Gesellschaft 3, no. 2 (2005): 97–104. http://dx.doi.org/10.1111/j.1610-0378.2005.04089.x.

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Pervadchuk, V., D. Vladimirova, D. Dektiarev, and A. Pesterev. "DESIGNING OF OPTIMAL STABILIZING REGULATOR IN THE MCVD PROCESS." Applied Photonics 4, no. 3 (2017): 212–21. http://dx.doi.org/10.15593/2411-4367/2017.03.04.

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Bognár, Erzsébet, Gabriella Hellner, Andrea Radnóti, László Somogyi, and Zsolt Kemény. "Effect of Different Chlorine Sources on the Formation of 3-Monochloro-1,2-Propanediol and 2-Monochloro-1,3-Propanediol Fatty Acid Esters during Frying." Periodica Polytechnica Chemical Engineering 64, no. 4 (2019): 523–29. http://dx.doi.org/10.3311/ppch.14137.

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Several studies indicated that chlorine salts provoke 3-monochloro-1,2-propanediol fatty acid esters (3-MCPD-FE) and 2-monochloro-1,3- propanediol fatty acid esters (2-MCPD-FE) formation in oils during frying. The amount of MCPD strongly depends on the type and the amount of chlorine salt. Food raw materials, additives themselves may contain several chlorine compounds, providing precursors for 2- and 3-MCPD-FE formation during frying. Then, the fat uptake can cause measurable concentrations in the fried food as well. This paper aims at screening chlorine compounds occurring in food industry. I

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MAEKAWA, Kazuyo, Yuko HAMADA, Motoyoshi MARUNO, Shigeo NONAKA, Fumio NAGAMINE, and Nobuyuki TAKASU. "MCTD with Pulmonary Hypertension." Nishi Nihon Hifuka 61, no. 4 (1999): 438–42. http://dx.doi.org/10.2336/nishinihonhifu.61.438.

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Dearlove, O. R., and R. Perkins. "MCAD deficiency and anaesthesia." Anaesthesia 50, no. 3 (1995): 265. http://dx.doi.org/10.1111/j.1365-2044.1995.tb04584.x.

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Aksenov, V. A., G. A. Ivanov, V. A. Isaev, and M. E. Likhachev. "MCVD of fluorosilicate glass." Inorganic Materials 46, no. 9 (2010): 994–97. http://dx.doi.org/10.1134/s002016851009013x.

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Andresen, Brage Storstein, Allan Meldgaard Lund, David Michael Hougaard, et al. "MCAD deficiency in Denmark." Molecular Genetics and Metabolism 106, no. 2 (2012): 175–88. http://dx.doi.org/10.1016/j.ymgme.2012.03.018.

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Cohen, Elaine, Tom Lyche, and Richard F. Riesenfeld. "MCAD: Key historical developments." Computer Methods in Applied Mechanics and Engineering 199, no. 5-8 (2010): 224–28. http://dx.doi.org/10.1016/j.cma.2009.08.003.

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LEVI, NOAH J., JOO YUN JUN, TUSHAR P. PATEL, ANDREW J. UHLMAN, ROBIN ROBERSON, and JACK A. YANOVSKI. "Liver-Specific Reactivation of MC3R Partially Reverses the Obesity of MC3R Deficiency." Diabetes 67, Supplement 1 (2018): 2017—P. http://dx.doi.org/10.2337/db18-2017-p.

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Lê Đình, Chi, Thượng Nguyễn Như, Tú Vũ Ngọc, Hồng Hảo Lê Thị та Sơn Trần Cao. "Xác định đồng thời các dạng ester của 3-MCPD và 2-MCPD trong sữa công thức bằng GC-MS/MS". Heavy metals and arsenic concentrations in water, agricultural soil, and rice in Ngan Son district, Bac Kan province, Vietnam 3, № 2 (2020): 133–44. http://dx.doi.org/10.47866/2615-9252/vjfc.653.

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Nghiên cứu đã phát triển và thẩm định phương pháp xác định đồng thời các dạng ester của 3-MCPD và 2-MCPD trong sữa công thức bằng GC-MS/MS. Các ester của MCPD được chiết từ mẫu sữa công thức bằng hỗn hợp ethanol/n-hexane/diethyl ether (1/1/1, v/v/v), sau đó được xử lý với acid sulfuric để giải phóng dạng tự do. Các chất 3-MCPD và 2-MCPD dạng tự do và nội chuẩn đồng vị 3-MCPD-d5 and 2-MCPD-d5 được dẫn xuất với acid phenylboronic và sau đó dẫn xuất được phân tích bằng GC-MS/MS ở chế độ MRM. Cột tách được sử dụng là cột mao quản DB-5MS, khí mang là Heli ở tốc độ 1 mL/phút. Chế độ MRM đã được sử d

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Doležal, M., P. Calta, and J. Velíšek. "Formation and decomposition of 3-chloropropane-1,2-diol in model systems." Czech Journal of Food Sciences 22, SI - Chem. Reactions in Foods V (2004): S263—S266. http://dx.doi.org/10.17221/10677-cjfs.

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Model experiments were carried out using mixtures of 3-chloropropane-1,2-diol (3-MCPD), its precursor glycerol, NaCl, water and an emulsifier. The aim of this study was to simulate formation and decomposition of 3-MCPD at the surface layers of thermally processed foods containing naturally present or intentionally added salt. The formed 3-MCPD levels depend on temperature and reach the maximum value at 230°C. One kg of glycerol gives rise to about 50 mg of 3-MCPD, while about 0.6 mg of 3-MCPD arise at 100°C. The rate constants k<sub>1</sub> of 3-MCPD formation from glycerol and con

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Bedenbaugh, Michelle N., Serena Sweet, Haley Mendoza-Romero, et al. "28 Melanocortin 3 Receptor in Neural Circuits Linking Metabolic State with Reproduction and Growth." Journal of Animal Science 101, Supplement_3 (2023): 231–32. http://dx.doi.org/10.1093/jas/skad281.280.

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Abstract Metabolic state must be communicated to the brain to regulate behavior, growth, nutrient partitioning and development to meet energetic demands. While it is clearly evident that reproduction and energy balance are closely intertwined, the neural circuits integrating these two processes are poorly understood. Recent functional data suggests the melanocortin 3 receptor (MC3R) mediates the exchange of information between reproductive and metabolic state. Additionally, females exhibit uniquely aberrant metabolic and reproductive phenotypes after deletion of MC3R. In this work, we aimed to

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Chambers, Christopher V., William T. Leach, Kaitlyn Davis, and Ronald E. Myers. "Primary Care Provider Receptivity to Multi-Cancer Early Detection Test Use in Cancer Screening." Journal of Personalized Medicine 13, no. 12 (2023): 1673. http://dx.doi.org/10.3390/jpm13121673.

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Multi-cancer early detection tests (MCEDs) are blood-based tests that detect biomarkers released or induced by cancer cells. If MCED tests are shown to be safe and effective in cancer screening, they are likely to be ordered and managed in primary care. To understand primary care providers’ support for and concerns about the implementation and management of MCED testing, the research team developed a cross-sectional survey that was sent to 939 primary care providers (physicians, residents/fellows, and advanced practice providers) in a large academic health system in the greater Philadelphia ar

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Ji, Ren-Lei, Lu Huang, Yin Wang, et al. "Topmouth culter melanocortin-3 receptor: regulation by two isoforms of melanocortin-2 receptor accessory protein 2." Endocrine Connections 10, no. 11 (2021): 1489–501. http://dx.doi.org/10.1530/ec-21-0459.

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Melanocortin-3 receptor (MC3R) is a regulator of energy homeostasis, and interaction of MC3R and melanocortin-2 receptor accessory protein 2 (MRAP2) plays a critical role in MC3R signaling of mammals. However, the physiological roles of MC3R in teleosts are not well understood. In this study, qRT-PCR was used to measure gene expression. Radioligand binding assay was used to study the binding properties of topmouth culter MC3R (caMC3R). Intracellular cAMP generation was determined by RIA, and caMC3R expression was quantified with flow cytometry. We showed that culter mc3r had higher expression

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Lippert, Rachel N., Kate L. J. Ellacott, and Roger D. Cone. "Gender-Specific Roles for the Melanocortin-3 Receptor in the Regulation of the Mesolimbic Dopamine System in Mice." Endocrinology 155, no. 5 (2014): 1718–27. http://dx.doi.org/10.1210/en.2013-2049.

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The melanocortin-3 receptor (MC3R) and MC4R are known to play critical roles in energy homeostasis. However, the physiological functions of the MC3R remain poorly understood. Earlier reports indicated that the ventral tegmental area (VTA) is one of the highest sites of MC3R expression, and we sought to determine the function of the receptor in this brain region. A MC3R-green-fluorescent protein transgenic mouse and a MC3R knockout mouse strain were used to characterize the neurochemical identity of the MC3R neurons in the VTA and to determine the effects of global MC3R deletion on VTA dopamine

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Gao, Boyan, Yanfang Li, Guoren Huang, and Liangli Yu. "Fatty Acid Esters of 3-Monochloropropanediol: A Review." Annual Review of Food Science and Technology 10, no. 1 (2019): 259–84. http://dx.doi.org/10.1146/annurev-food-032818-121245.

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Fatty acid esters of 3-monochloropropane-1,2-diol (3-MCPD esters) are a new group of processing-induced chemical toxicants with possible nephrotoxicity and testicular toxicity. 3-MCPD esters have been detected in many food categories, including refined edible oils, bread, coffee, and infant formula. 3-MCPD esters have also been detected in human breast milk, indicating their possible absorption and distribution in human organs and tissues. 3-MCPD esters have become a food safety concern, and in 2013 the European Food Safety Authority estimated a tolerable daily value (TDI) of 2 μg/kg body weig

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M Breitling-Utzmann, C., H. Hrenn, N. U Haase, and G. M Unbehend. "Influence of dough ingredients on 3-Mcpd formation in toast." Czech Journal of Food Sciences 22, SI - Chem. Reactions in Foods V (2004): S25—S28. http://dx.doi.org/10.17221/10605-cjfs.

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The influences of both traditional dough ingredients like fat and salt and a commercially used baking agent on the formation of 3-chloropropane-1,2-diol (3-MCPD) during toasting of bread were investigated. Whereas varying the fat or salt contents within technologically practicable limits showed negligible effects on 3-MCPD formation, the baking agent turned out to have a crucial impact on generating 3-MCPD in toasted bread slices. We found considerable evidence that the baking agent’s main component saccharose was the major cause for its boosting the 3-MCPD formation. Emulsifiers like mono- an

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Sweeney, Patrick, Michelle N. Bedenbaugh, Jose Maldonado, et al. "The melanocortin-3 receptor is a pharmacological target for the regulation of anorexia." Science Translational Medicine 13, no. 590 (2021): eabd6434. http://dx.doi.org/10.1126/scitranslmed.abd6434.

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Ablation of hypothalamic AgRP (Agouti-related protein) neurons is known to lead to fatal anorexia, whereas their activation stimulates voracious feeding and suppresses other motivational states including fear and anxiety. Despite the critical role of AgRP neurons in bidirectionally controlling feeding, there are currently no therapeutics available specifically targeting this circuitry. The melanocortin-3 receptor (MC3R) is expressed in multiple brain regions and exhibits sexual dimorphism of expression in some of those regions in both mice and humans. MC3R deletion produced multiple forms of s

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Park, Jeenah, Neeraj Sharma, and Garry R. Cutting. "Melanocortin 3 Receptor Has a 5′ Exon That Directs Translation of Apically Localized Protein From the Second In-Frame ATG." Molecular Endocrinology 28, no. 9 (2014): 1547–57. http://dx.doi.org/10.1210/me.2014-1105.

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Melanocortin-3 receptor (MC3R) is a canonical MSH receptor that plays an essential role in energy homeostasis. Variants in MC3R have been implicated in obesity in humans and mice. However, interpretation of the functional consequences of these variants is challenging because the translational start site of MC3R is unclear. Using 5′ rapid amplification of cDNA ends, we discovered a novel upstream exon that extends the length of the 5′ untranslated region (UTR) in MC3R without changing the open-reading frame. The full-length 5′ UTR directs utilization of an evolutionarily conserved second in-fra

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