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Journal articles on the topic 'MCF1'

Author: Grafiati

Published: 7 June 2025

Last updated: 16 July 2025

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1

Zhang, Tao, Xiaojun Wang, Zhifeng Jin, Shamsuddin Shahid, and Bo Bi. "Climate Impact on Irrigation Water Use in Jiangsu Province, China: An Analysis Using Empirical Mode Decomposition (EMD)." Water 15, no. 16 (2023): 3013. http://dx.doi.org/10.3390/w15163013.

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In this paper, the quantitative effects of climatic factor changes on irrigation water use were analyzed in Jiangsu Province from 2004 to 2020 using the Empirical Mode Decomposition (EMD) time-series analysis method. In general, the irrigation water use, precipitation (P), air temperature (T), wind speed (Ws), relative humidity (Rh) and water vapor pressure (Vp) annual means ± standard deviation were 25.44 ± 1.28 billion m3, 1034.4 ± 156.6 mm, 16.1 ± 0.4 °C, 2.7 ± 0.2 m·s−1, 74 ± 2%, and 15.5 ± 0.6 hPa, respectively. The analysis results of the irrigation water use sequence using EMD indicate

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Feng, Ming, Yang Lei, Zhixiang Chen, Xianglei Zhang, Xizhang Chen, and Youliang Wang. "Whole Elliptical Surface Polishing Using a Doughnut-Shaped MCF Polishing Tool with Variable Tilt Angle." Lubricants 10, no. 10 (2022): 232. http://dx.doi.org/10.3390/lubricants10100232.

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Elliptical elements are essential optical surfaces for modifying optical systems. For polishing the whole elliptical surface using doughnut-shaped MCF polishing tool with variable tilt angle, an experimental investigation was conducted in this work. Firstly, a flat workpiece was polished to determine the polishing feasibility. It was found that the middle portion of the polishing tool had optimal ability to remove materials, and the surface roughness Sa at the material removal peak was changed from 134 nm to 17.5 nm within 50 min of polishing. A smoother surface could be obtained using MCF2 sl

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Chen, Tsute, Lillian Ouko, Thomas Warnick, and Susan Leschine. "Detection, Cloning, and Sequence Analysis of an Indigenous Plasmid from Cellulolytic Clostridial Strain MCF1." Plasmid 43, no. 2 (2000): 153–58. http://dx.doi.org/10.1006/plas.1999.1439.

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González-Zamora, Alfredo, Manuel Esperón-Rodríguez, and Víctor L. Barradas. "Mountain cloud forest and grown-shade coffee plantations: A comparison of tree biodiversity in central Veracruz, Mexico." Forest Systems 25, no. 1 (2016): 055. http://dx.doi.org/10.5424/fs/2016251-07538.

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Aim of the study: The objective of this work is to compare tree diversity and richness among one grown-shade coffee plantation (CAE) and two sites of montane cloud forests, one preserved (MCF1) and other perturbed (MCF2). We also develop an analysis of the importance of coffee plantations as a refuge of tree species, holding a potential role for conservation.Area of study: Our study area is the coffee region of Coatepec-Xico, in the state of Veracruz, Mexico.Material and methods: We compiled a list of all tree species in each site to determine tree diversity and floristic similarity (dissimila

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Amukti, D.P., L.M. Irham, S. Surono, et al. "Genomic variants and epidemiology of atherosclerosis – worldwide correlation analysis and utilization of atherosclerosis gene variants for identification of drug target candidates with bioinformatics approach." Bulgarian Cardiology 30, no. (4) (2024): 108–20. https://doi.org/10.3897/bgcardio.30.e145391.

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<em>Introduction:</em> Atherosclerosis (AS) is a major risk factor for cardiovascular disease (CVD), which is the leading cause of death worldwide. Genetic factors are an integral factor in the cause of AS. This study aims to correlate epidemiological data, prevalence and mortality of AS worldwide with Single Nucleotide Polymorphisms (SNPs) associated with susceptibility and severity in different populations. Hence, utilized the gene variants to discover potential drug targets using bioinformatics. <em>Material and methods:</em> This study used a secondary data-driven bioinformatics approach t

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Dowling, Andrea J., Nicholas R. Waterfield, Michelle C. Hares, Gaëlle Le Goff, Charles H. Streuli, and Richard H. ffrench-Constant. "The Mcf1 toxin induces apoptosis via the mitochondrial pathway and apoptosis is attenuated by mutation of the BH3-like domain." Cellular Microbiology 9, no. 10 (2007): 2470–84. http://dx.doi.org/10.1111/j.1462-5822.2007.00974.x.

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Hassaneen, Hamdi M., Fatma M. Saleh, Tayseer A. Abdallah, et al. "Synthesis, Cytotoxicity, Antimicrobial and Docking Simulation of Novel Pyrazolo[3,4-d]pyrimidine and pyrazolo[4,3-e][1,2,4]triazolo[3,4-c] pyrimidine Derivatives." Mini-Reviews in Medicinal Chemistry 19, no. 8 (2019): 657–70. http://dx.doi.org/10.2174/1389557518666181017162459.

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Background:Isobutyrohydrazonoyl bromide 1 was used as a precursor for the synthesis of 4-imino-3-isopropyl-1-(4-nitrophenyl)-1,4-dihydro-5H-pyrazolo[3,4-d]pyrimidin-5-amine 4, which was converted into hydrazino derivative 5 by heating with hydrazine hydrate at reflux. Hydrazino, as well as imino-amino derivatives, underwent condensation and cyclization reactions to give pyrazolo[ 3,4-d]pyrimidine and pyrazolo[4,3-e][1,2,4]triazolo[3,4-c]pyrimidine derivatives, respectively.Method:Antimicrobial studies are performed using two-gram positive bacteria and two-gram negative bacteria.Results:Data re

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Singhal, Mitali, Jacobo Elies Gomez, Sanjit Nayak, Kirsten Riches Suman, and Amalia Ruiz Estrada. "Abstract 4386: Comparison of cytotoxicity of anthracycline based antineoplastic drugs in breast cancer." Cancer Research 83, no. 7_Supplement (2023): 4386. http://dx.doi.org/10.1158/1538-7445.am2023-4386.

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Abstract Mitoxantrone (MTX) is used for the chemotherapeutic treatment of breast cancer, but it has a dose-limiting cardiotoxicity. One of the mechanisms of MTX cytotoxicity is by inhibiting the topoisomerase II enzyme, which is crucial for maintaining cellular processes like replication. The aim of the study is to investigate if an alternative analog of MTX, named KP71 would be a suitable antineoplastic drug with reduced cardiovascular side effects. Cytotoxicity of both drugs in breast cancer cell lines MDA-MB-468, MDA-MB-231, MCF7, the non-neoplastic breast cell line MCF10, cardiac human fib

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Chen, Brandon, Wong Pamela, Daniel Auclair, et al. "Myeloma Patient-Derived MCL1 Point Mutations Can Influence MCL1-Inhibitor Function." Blood 132, Supplement 1 (2018): 951. http://dx.doi.org/10.1182/blood-2018-99-113444.

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Abstract Multiple myeloma is a malignancy of long-lived plasma cells of the bone marrow that is rarely curable. Thus, despite recent advances in the development of new therapies, additional approaches are required. We investigated potential molecular vulnerabilities in the BCL2 family. Using the MMRF CoMMpass (NCT0145429) study (IA13), we determined the frequency of nonsynonymous coding mutations in the BCL2 family. Analysis of baseline samples from 982 patients revealed that mutations in the BCL2 family are relatively rare events. No mutations were observed in the 3 pro-apoptotic effector gen

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Musa, A., H. J. Steeman, and M. De Paepe. "Performance of Internal and External Reforming Molten Carbonate Fuel Cell Systems." Journal of Fuel Cell Science and Technology 4, no. 1 (2006): 65–71. http://dx.doi.org/10.1115/1.2393306.

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Molten carbonate fuel cells (MCFC) are a promising alternative power source for distributed or residential power plants. Therefore, thermodynamic models are built in an Aspen customer modeler for the externally reformed (ER) MCFC and internally reformed (IR) MCFC. These models are integrated in Aspen Plus™. In this article the performance of internal and external reforming molten carbonate fuel cell systems are investigated. To this end the gas temperature at the anode inlet is varied to be able to exam the effect of operating temperature on the operating conditions for different modes of MCFC

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Cao, Yong Jie, Ming Xian Liu, Li Hua Gan, et al. "Preparation and Electrochemical Properties of Fluorinated Mesoporous Carbon Foams for Electric Double-Layer Capacitors." Advanced Materials Research 239-242 (May 2011): 3190–93. http://dx.doi.org/10.4028/www.scientific.net/amr.239-242.3190.

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We reported the preparation and electrochemical properties of fluorinated mesoporous carbon foams (F-MCFs) for application as electric double-layer capacitors (EDLCs). By using fluorinated resol which was obtained from the polymerization of formaldehyde, phenol, and 3-fluorophenol as the carbon source and fluorin precursor, and triblock copolymer F127 as a template, F-MCFs were prepared through evaporation induced self-assembly strategy. The F-MCFs were characterized by N2 adsorption and desorption, transmission electron microscopy (TEM) and small-angle X-ray scattering (SAXS). The results ind

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Rousseau, Aurélie, Patrick Van Dreden, Amir Khaterchi, et al. "Acquision of Resistance to Doxorubicin By Breast Cancer Cells MCF7 Enhances Their Procoagulant Properties and Alters the Efficacy of Antithrombotic Agents to Inhibit Thrombin Generation." Blood 126, no. 23 (2015): 1113. http://dx.doi.org/10.1182/blood.v126.23.1113.1113.

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Abstract Introduction: A major problem associated with breast cancer chemotherapy is the subsequent development of resistance to chemotherapeutic agents (multidrug résistance-MDR). Hypercoagulability, increased risk of venous thromboebolism (VTE) and high rate of failure of the antithrombotic treatment with LMWHs have been observed in patients with disease resistant to the chemotherapy. Aim of the study: In the present study we investigated if acquisition of MDR by breast cancer cells MCF7 is associated with modification of their procoagulant potency and induces alteration of the efficacy of t

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Tian, Yu Dong. "Research of Molten Carbonate Fuel Cells Modeling Based on Neural Computing." Applied Mechanics and Materials 389 (August 2013): 81–84. http://dx.doi.org/10.4028/www.scientific.net/amm.389.81.

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The molten carbonate fuel cell (MCFC) is an important research field of the new energy generation equipment, and is a difficulty in the research field of high-temperature fuel cells at present. To aim at the MCFC modeling problem, the MCFC electrochemical mechanism process was analyzed firstly, then the MCFC modeling applied neural computing is advanced. Thirdly, the structure, algorithm and simulation of MCFC modeling based on feedback neural networks were presented in detail. Finally, the computer simulation and conducted experiment verified that this model was fast and accurate, and can be

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Chang, Victoria K., Michael J. Fitch, Justin J. Donato, Tim W. Christensen, A. Margaret Merchant, and Bik K. Tye. "Mcm1 Binds Replication Origins." Journal of Biological Chemistry 278, no. 8 (2002): 6093–100. http://dx.doi.org/10.1074/jbc.m209827200.

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Haas, Michael J. "MCL1's resistance story." Science-Business eXchange 4, no. 11 (2011): 300. http://dx.doi.org/10.1038/scibx.2011.300.

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Boise, L. H., S. M. Matulis, V. Gupta, et al. "Inhibitors (BCL2 - MCL1 - CDK)." Clinical Lymphoma Myeloma and Leukemia 15 (September 2015): e20. http://dx.doi.org/10.1016/j.clml.2015.08.042.

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Yao, Yao, and Stella E. Tsirka. "Mouse MCP1 C-terminus inhibits human MCP1-induced chemotaxis and BBB compromise." Journal of Neurochemistry 118, no. 2 (2011): 215–23. http://dx.doi.org/10.1111/j.1471-4159.2011.07319.x.

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LIU, Hui, Heng-wei ZHANG, Xian-fu SUN, et al. "Tamoxifen-resistant breast cancer cells possess cancer stem-like cell properties." Chinese Medical Journal 126, no. 16 (2013): 3030–34. http://dx.doi.org/10.3760/cma.j.issn.0366-6999.20130227.

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Background Cancer stem cells (CSCs) are the cause of cancer recurrence because they are resistant to conventional therapy and contribute to cancer growth and metastasis. Endocrinotherapy is the most common breast cancer therapy and acquired tamoxifen (TAM) resistance is the main reason for endocrinotherapy failure during such therapy. Although acquired resistance to endocrine treatment has been extensively studied, the underlying mechanisms are unclear. We hypothesized that breast CSCs played an important role in TAM-induced resistance during breast cancer therapy. Therefore, we investigated t

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Chang, Steven, Lata Singh, Kunal Thaker, et al. "Altered Retrograde Signaling Patterns in Breast Cancer Cells Cybrids with H and J Mitochondrial DNA Haplogroups." International Journal of Molecular Sciences 23, no. 12 (2022): 6687. http://dx.doi.org/10.3390/ijms23126687.

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The aim of this study was to determine the role of retrograde signaling (mitochondria to nucleus) in MCF7 breast cancer cells. Therefore, in the present study, MCF7-H and MCF7-J cybrids were produced using the mitochondria from the same H and J individuals that were already used in our non-diseased retinal pigment epithelium (ARPE19) cybrids. MCF7 cybrids were treated with cisplatin and analyzed for cell viability, mitochondrial membrane potential, ROS, and expression levels of genes associated with the cGAS-STING and cancer-related pathways. Results showed that unlike the ARPE19-H and ARPE19-

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Brossay, L., D. Jullien, S. Cardell, et al. "Mouse CD1 is mainly expressed on hemopoietic-derived cells." Journal of Immunology 159, no. 3 (1997): 1216–24. http://dx.doi.org/10.4049/jimmunol.159.3.1216.

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Abstract The mouse CD1 (mCD1) is a class I-like molecule that is encoded outside the MHC. Recent studies demonstrate that mCD1 presents hydrophobic peptides to CD8+ T cells and also that it is recognized by a population of NK1.1+ T cells that are thought to play an immunoregulatory role because of their ability to secrete IL-4. It has previously been reported that mCD1 is expressed predominantly by intestinal epithelial cells, although most NK1.1+ T cells are located elsewhere. We, therefore, have generated new mAbs to mCD1 to investigate its tissue distribution. The principal site of mCD1 exp

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Todorova, Jordana, Shazie Myashkova, Maria Petrova, Anastas Gospodinov, and Evdokia Pasheva. "The motility of breast cancer cells is stimulated by HMGB1/RAGE interaction but the truncated form lacking the C terminus has no effect." BioDiscovery 24 (September 12, 2022): e93641. https://doi.org/10.3897/biodiscovery.24.e93641.

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HMGB1/RAGE is identified as a ligand-receptor pair that plays an important role in tumorogenesis. HMGB1 and RAGE levels are higher in most human tumors and their overexpression is associated with tumor progression. The causes of breast cancer are still poorly understood. One reason might be the existence of subtypes within various cellular mechanisms as hormone-dependent and hormone -independent malignant processes. We investigated the effect of HMGB1 protein and its truncated form lacking the C terminus on the RAGE expression and cell motility of breast cancer cell lines; MCF7-noninvasive, MD

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Kurniawan, Edy, sompong o-thong, Yves Gagnon, and Benjamas Cheirsilp. "Effect of inoculum source, electron donors, and substrates on medium-chain fatty acid production from palm oil mill effluent." Industrial Crops and Products 206 (November 15, 2023): 117654. https://doi.org/10.1016/j.indcrop.2023.117654.

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Selecting an appropriate inoculum source and electron donor for chain elongation is crucial to optimizing medium-chain fatty acid (MCFA) production from organic waste. The investigation examined the impact of various factors, including inoculum source, electron donors, and substrate composition, on MCFA production from palm oil mill effluent (POME). The substrate containing a mixture of ethanol, lactic acid, and acetic acid exhibited the highest MCFA production, reaching 0.4–0.5 g-COD/L. Among the cultures tested, the compost (CP)-enriched culture demonstrated the highest MCFA production

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Burdin, Nicolas, Laurent Brossay, Yasuhiko Koezuka та ін. "Selective Ability of Mouse CD1 to Present Glycolipids: α-Galactosylceramide Specifically Stimulates Vα14+ NK T Lymphocytes". Journal of Immunology 161, № 7 (1998): 3271–81. http://dx.doi.org/10.4049/jimmunol.161.7.3271.

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Abstract Mouse CD1 (mCD1) glycoproteins are known to present peptides, while human CD1 molecules present glycolipids. In mice, mCD1-autoreactive NK T cells play critical roles in various immune responses, through the secretion of high amounts of cytokines. This study was initiated to determine whether glycolipids are involved in the autorecognition of mCD1 by NK T cells. α-Galactosylceramide (α-GalCer) was the only glycolipid tested capable of eliciting an mCD1-restricted response by splenic T cells. Moreover, splenic T cells derived from mCD1-deficient mice were not stimulated by α-GalCer, su

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Watanabe, Takayuki, Takaaki Oba, Keiji Tanimoto, Tomohiro Shibata, Shinobu Kamijo, and Ken-ichi Ito. "Tamoxifen resistance alters sensitivity to 5-fluorouracil in a subset of estrogen receptor-positive breast cancer." PLOS ONE 16, no. 6 (2021): e0252822. http://dx.doi.org/10.1371/journal.pone.0252822.

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Sequential treatment with endocrine or chemotherapy is generally used in the treatment of estrogen receptor (ER)-positive recurrent breast cancer. To date, few studies have investigated the effect of long-term endocrine therapy on the response to subsequent chemotherapy in ER-positive breast cancer. We examined whether a preceding endocrine therapy affects the sensitivity to subsequent chemotherapy in ER-positive breast cancer cells. Three ER-positive breast cancer cell lines (T47D, MCF7, BT474) and tamoxifen-resistant sublines (T47D/T, MCF7/T, BT474/T) were analyzed for sensitivity to 5-fluor

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Fukuzawa, Satoshi, Kenji Yamagata, Yuuma Hasegawa, et al. "Comparison of Postoperative Bleeding between Application of Polyglycolic Acid Sheet and Primary Closure in Tongue Cancer Patients with Partial Glossectomy." Dentistry Journal 8, no. 3 (2020): 85. http://dx.doi.org/10.3390/dj8030085.

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The technique of covering a mucosal defect with fibrin glue and a polyglycolic acid sheet (MCFP) for the resection of mucosa is applied in oral cancers. The MCFP technique for partial glossectomy provides faster relief from postoperative pain and the prevention of scar contracture, unlike primary closure. However, it has a major complication of postoperative bleeding. This study sought to compare postoperative bleeding between the MCFP technique and primary closure. We designed a retrospective study with a cohort of 57 patients who underwent partial glossectomy with the MCFP technique or prima

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Scherbakov, Alexander M., Anna A. Basharina, Danila V. Sorokin, et al. "Targeting hormone-resistant breast cancer cells with docetaxel: a look inside the resistance." Cancer Drug Resistance 6, no. 1 (2023): 103–15. http://dx.doi.org/10.20517/cdr.2022.96.

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Aim: The study aims to analyze the effect of long-term incubation of ERα-positive MCF7 breast cancer cells with 4-hydroxytamoxifen (HT) on their sensitivity to tubulin polymerization inhibitor docetaxel. Methods: The analysis of cell viability was performed by the MTT method. The expression of signaling proteins was analyzed by immunoblotting and flow cytometry. ERα activity was evaluated by gene reporter assay. To establish hormone-resistant subline MCF7, breast cancer cells were treated with 4-hydroxytamoxifen for 12 months. Results: The developed MCF7/HT subline has lost sensitivity to 4-hy

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Teitell, M., H. R. Holcombe, L. Brossay, et al. "Nonclassical behavior of the mouse CD1 class I-like molecule." Journal of Immunology 158, no. 5 (1997): 2143–49. http://dx.doi.org/10.4049/jimmunol.158.5.2143.

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Abstract The mouse CD1 (mCD1) molecule is a class I-like molecule that is encoded outside of the MHC. We show here that mCD1 shares several properties with Ag-presenting class I molecules, including a requirement for beta2-microglobulin for stable cell-surface expression in T lymphocyte transfectants and thymocytes. mCD1 is also capable of binding to mouse CD8alphabeta heterodimers participating in the activation of CD8+ T cells in a manner similar to classical class I molecules. However, mCD1 surface expression is not decreased at high temperatures in cells that lack the transporter associate

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Troitskaya, Olga, Diana Novak, Anna Nushtaeva, et al. "EGFR Transgene Stimulates Spontaneous Formation of MCF7 Breast Cancer Cells Spheroids with Partly Loss of HER3 Receptor." International Journal of Molecular Sciences 22, no. 23 (2021): 12937. http://dx.doi.org/10.3390/ijms222312937.

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Multicellular spheroids with 3D cell–cell interactions are a useful model to simulate the growth conditions of cancer. There is evidence that in tumor spheroids, the expression of various essential molecules is changed compared to the adherent form of cell cultures. These changes include growth factor receptors and ABC transporters and result in the enhanced invasiveness of the cells and drug resistance. It is known that breast adenocarcinoma MCF7 cells can spontaneously form 3D spheroids and such spheroids are characterized by high expression of EGFR/HER2, while the natural phenotype of MCF7

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Daniel, Petr, Petr Halada, Michael Jelínek, Kamila Balušíková, and Jan Kovář. "Differentially Expressed Mitochondrial Proteins in Human MCF7 Breast Cancer Cells Resistant to Paclitaxel." International Journal of Molecular Sciences 20, no. 12 (2019): 2986. http://dx.doi.org/10.3390/ijms20122986.

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Identification of novel proteins with changed expression in resistant cancer cells could be helpful in elucidation mechanisms involved in the development of acquired resistance to paclitaxel. In this study, we carried out a 2D-PAGE using the mitochondrial-enriched fraction from paclitaxel-resistant MCF7/PacR cells compared to original paclitaxel-sensitive MCF7 breast cancer cells. Differentially expressed proteins were identified employing mass spectrometry. We found that lysosomal cathepsin D and mitochondrial abhydrolase-domain containing protein 11 (ABHD11) had decreased expression in MCF7/

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Tian, Yu Dong. "Research for Experiment of Molten Carbonate Fuel Cells Generation." Applied Mechanics and Materials 193-194 (August 2012): 522–25. http://dx.doi.org/10.4028/www.scientific.net/amm.193-194.522.

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The molten carbonate fuel cell (MCFC) is an important research field of the new energy generation equipment. To aim at the problem that MCFC electrical characteristics reflect the generating performance, the electrochemical process mechanism of MCFC electrochemical reaction was analyzed firstly, then an electrical model of MCFC electrical characteristics based on the electrochemical process was advanced. Thirdly, the hot start process, and the output test of MCFC generation applied the experiment were particularly presented. Finally, the experimental results proved that it was fast and accurat

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Flores-Peña, Yolanda, María Eugenia Pérez-Campa, Hermelinda Ávila-Alpirez, Juana Mercedes Gutiérrez-Valverde, and Gustavo Gutiérrez-Sánchez. "Depressive symptoms, maternal feeding styles, and preschool child’s body weight." Salud mental 44, no. 6 (2021): 261–66. http://dx.doi.org/10.17711/sm.0185-3325.2021.034.

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Introduction. Depressive symptoms (DS) can impact maternal child feeding styles (MCFS), and child’s body weight. Objective. 1. Verify if DS are different depending if the child has, or not, overweight-obesity (OW-OB); 2. Identify the MCFS based on the fact that the child has, or not, OW-OB; 3. Verify it DS are different according to MCFS; 4. Identify DS’s predictors. Method. Correlational cross-sectional study. The participants were 259 dyads (mother- preschool child) residents in Mexico’ Northeast. Mothers answered the Center for Epidemiologic Studies Depression Scale, Revised, and the Caregi

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Sung, Tae Hong, and Kyung Chun Kim. "Design of Dynamic MCFC Simulation Bed for MBOP Feasibility Test of Marine Applications." Applied Mechanics and Materials 291-294 (February 2013): 589–92. http://dx.doi.org/10.4028/www.scientific.net/amm.291-294.589.

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Molten carbonate fuel cell (MCFC) is achieving relatively high output and efficiency and reaching the level of commercialization compared to other fuel cells. Recently many studies are dealt with mobile applications of MCFC to use those superlative properties. But until now, researches are dealt with steady state energy analysis and life cycle assessment analysis. The practical dynamic feasibility analysis has not been done. Here we report, dynamic MCFC model and simultaneous mechanical balance of plant (MBOP) test algorithm can be used for evaluating feasibility of MCFC marine application. We

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Saitoh, Kunimasa, and Shoichiro Matsuo. "Multicore fibers for large capacity transmission." Nanophotonics 2, no. 5-6 (2013): 441–54. http://dx.doi.org/10.1515/nanoph-2013-0037.

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AbstractWe experience Internet traffic growth of 100 times every 10 years. However, the capacity of existing standard single-mode fiber is approaching its fundamental limit regardless of significant realization of transmission technologies which allow for high spectral efficiencies. Space division multiplexing (SDM) based on multicore fibers (MCFs) has emerged as a solution to the problem of saturation of the capacity of optical transmission systems. This article presents the recent progress on the MCFs for future large capacity long-distance transmission systems. In MCFs, there is a tradeoff

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Casali, Nicola, Amy M. White, and Lee W. Riley. "Regulation of the Mycobacterium tuberculosis mce1 Operon." Journal of Bacteriology 188, no. 2 (2006): 441–49. http://dx.doi.org/10.1128/jb.188.2.441-449.2006.

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ABSTRACT In the murine model of infection, a Mycobacterium tuberculosis mce1 operon mutant elicits an aberrant granulomatous response, resulting in uncontrolled replication and failure to enter a persistent state. In this study, we demonstrate that the mce1 genes can be transcribed as a 13-gene polycistronic message encompassing Rv0166 to Rv0178. Quantitative reverse transcriptase PCR and immunoblot analyses revealed that the mce1 genes and proteins are expressed during in vitro growth but are significantly down-regulated in intracellular bacilli isolated from murine macrophages. A homologue o

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Maheshwari, Sunil Kumar, and N. Ravichandran. "Mangalore Chemicals and Fertilizers Limited: Strategic Renewal." Asian Case Research Journal 07, no. 02 (2003): 219–68. http://dx.doi.org/10.1142/s0218927503000409.

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This case provides a comprehensive account of the origin, foundation, growth, managerial and operational problems, labor relationship, decline in performance, change of ownership, and the initiatives taken by the new management team to revive the company. Mangalore was an initiative by Karnataka State Government in India. Originally, MCFL was conceived as a private sector organization. Eventually it was converted to a state-owned public sector undertaking. There was no accountability for the senior managers in managing the plant. Often, they had to make a trade off between their loyalty to the

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van Nocker, S., S. Sadis, D. M. Rubin, et al. "The multiubiquitin-chain-binding protein Mcb1 is a component of the 26S proteasome in Saccharomyces cerevisiae and plays a nonessential, substrate-specific role in protein turnover." Molecular and Cellular Biology 16, no. 11 (1996): 6020–28. http://dx.doi.org/10.1128/mcb.16.11.6020.

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The 26S proteasome is an essential proteolytic complex that is responsible for degrading proteins conjugated with ubiquitin. It has been proposed that the recognition of substrates by the 26S proteasome is mediated by a multiubiquitin-chain-binding protein that has previously been characterized in both plants and animals. In this study, we identified a Saccharomyces cerevisiae homolog of this protein, designated Mcb1. Mcb1 copurified with the 26S proteasome in both conventional and nickel chelate chromatography. In addition, a significant fraction of Mcb1 in cell extracts was present in a low-

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Birchmeier, C., D. Birnbaum, G. Waitches, O. Fasano, and M. Wigler. "Characterization of an activated human ros gene." Molecular and Cellular Biology 6, no. 9 (1986): 3109–16. http://dx.doi.org/10.1128/mcb.6.9.3109-3116.1986.

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A human oncogene, mcf3, previously detected by a combination of DNA-mediated gene transfer and a tumorigenicity assay, derives from a human homology of the avian v-ros oncogene. Both v-ros and mcf3 can encode a protein with homology to tyrosine-specific protein kinases, and both mcf3 and v-ros encode a potential transmembrane domain N terminal to the kinase domain. mcf3 probably arose during gene transfer from a normal human ros gene by the loss of a putative extracellular domain. There do not appear to be any other gross rearrangements in the structure of mcf3.

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Tian, Yu Dong. "Analysis for Modeling of Molten Carbonate Fuel Cells Material Characteristics." Advanced Materials Research 568 (September 2012): 344–47. http://dx.doi.org/10.4028/www.scientific.net/amr.568.344.

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The molten carbonate fuel cell (MCFC) is a difficulty in the research field of high-temperature fuel cells at present, and its strict hot start process and running status influence the material performance and life of the cell greatly. To deal with the problem, the MCFC mathematical modeling was analyzed firstly. Then a model of MCFC process based on material characteristics was advanced. Thirdly, the MCFC modeling structure, algorithm, and simulation applied the electrochemical processes were particularly presented. Finally, the results proved that it was fast and accurate, and provided the s

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Birchmeier, C., D. Birnbaum, G. Waitches, O. Fasano, and M. Wigler. "Characterization of an activated human ros gene." Molecular and Cellular Biology 6, no. 9 (1986): 3109–16. http://dx.doi.org/10.1128/mcb.6.9.3109.

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A human oncogene, mcf3, previously detected by a combination of DNA-mediated gene transfer and a tumorigenicity assay, derives from a human homology of the avian v-ros oncogene. Both v-ros and mcf3 can encode a protein with homology to tyrosine-specific protein kinases, and both mcf3 and v-ros encode a potential transmembrane domain N terminal to the kinase domain. mcf3 probably arose during gene transfer from a normal human ros gene by the loss of a putative extracellular domain. There do not appear to be any other gross rearrangements in the structure of mcf3.

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Novak, Elizabeth M., and Sheila M. Innis. "Impact of maternal dietary n-3 and n-6 fatty acids on milk medium-chain fatty acids and the implications for neonatal liver metabolism." American Journal of Physiology-Endocrinology and Metabolism 301, no. 5 (2011): E807—E817. http://dx.doi.org/10.1152/ajpendo.00225.2011.

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Levels of n-6, n-3, and medium-chain fatty acids (MCFA) in milk are highly variable. Higher carbohydrate intakes are associated with increased mammary gland MCFA synthesis, but the role of unsaturated fatty acids for milk MCFA secretion is unclear. This study addressed whether n-6 and n-3 fatty acids, which are known to inhibit hepatic fatty acid synthesis, influence MCFA in rat and human milk and the implications of varying MCFA, n-6, and n-3 fatty acids in rat milk for metabolic regulation in the neonatal liver. Rats were fed a low-fat diet or one of six higher-fat diets, varying in 16:0, 18

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Novak, Diana D., Olga S. Troitskaya, Anna A. Nushtaeva, et al. "EGFR Suppression Inhibits the Sphere Formation of MCF7 Cells Overexpressing EGFR." Acta Naturae 15, no. 2 (2023): 59–69. http://dx.doi.org/10.32607/actanaturae.17857.

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The epidermal growth factor receptor (EGFR) is an oncogenic tyrosine kinase that is involved in tumor initiation and progression, making EGFR inhibitors and monoclonal antibodies to this receptor essential for anti-tumor therapy. We have previously shown that EGFR transgene expression in the human breast adenocarcinoma cell line MCF7 (MCF7-EGFR) stimulates the 3D spheroid-like growth. The primary focus of our present work was to investigate whether EGFR inhibition could affect the assembly of spheroids or lead to the destruction of pre-existing spheroids. We compared the effects of anti-EGFR s

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Casco-Ojeda, Rubi, Yolanda Flores-Peña, Monserrat Morales-Alducin, Juana Mercedes Gutiérrez-Valverde, Hermelinda Avila-Alpirez, and Corina Mariela Alba-Alba. "Mindful Parenting, Maternal Child Feeding Style and Prescholer's Body Mass Index." Current Developments in Nutrition 5, Supplement_2 (2021): 966. http://dx.doi.org/10.1093/cdn/nzab051_010.

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Abstract Objectives To compare the dimensions and total score of Mindful Parenting (MP) according to the Maternal Child-Feeding Style (MCFS), 2) To identify the MCFS with the highest BMI average score and to verify if there are significant differences. Methods This study was of the descriptive and correlational type. The sample was determined for a multiple linear regression model with eight variables, significance of 0.5, test power of 90%, and effect size of .07. Participated, 334 dyads (mothers and her preschool child). The child attended 10 publish kindergartens in Monterrey, Nuevo Leon, M

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Yang, Chen, Kangjie Deng, Hangxing He, Haochuang Wu, Kai Yao, and Yuanzhe Fan. "Real-Time Interface Model Investigation for MCFC-MGT HILS Hybrid Power System." Energies 12, no. 11 (2019): 2192. http://dx.doi.org/10.3390/en12112192.

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The research on the control strategy and dynamic characteristics of the Molten Carbonate Fuel Cell-Micro Gas Turbine (MCFC-MGT) hybrid power system has received much attention. The use of the Hardware-In-the-Loop Simulation (HILS) method to study the MCFC-MGT hybrid power system, where the MCFC is the model subsystem and the MGT is the physical subsystem, is an effective means to save development cost and time. The difficulty with developing the MCFC-MGT HILS system is the transfer of the mass, energy, and momentum between the physical subsystem and the model subsystem. Hence, a new Simulation

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Sugino, T., A. Tateno, G. Ueno, et al. "Effects of calcium salts of medium-chain fatty acids on plasma metabolite and hormone concentrations in early lactating dairy cows." Animal Production Science 54, no. 10 (2014): 1699. http://dx.doi.org/10.1071/an14233.

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To elucidate the effects of medium-chain fatty acids (MCFA) on milk production and plasma metabolite and hormone concentrations in early lactating dairy cows, 10 multiparous Holstein dairy cows were randomly assigned to two dietary treatment groups after parturition. One group was fed a diet supplemented with calcium salts of MCFA (MCFA-Ca) for 8 weeks after parturition, while the other group was fed the same diet without the supplement (control). MCFA-Ca, containing 60% caprylic acid and 40% capric acid, was added to a total mixed ration (TMR) at 1.5% of the dietary dry matter (DM). Cows were

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Chornoguz, Olesya, Alexei Gapeev, Michael O'Neill, and Suzanne Ostrand-Rosenberg. "Ii- tumor cells present novel MHC II peptides that are tumor specific and immunogenic (52.18)." Journal of Immunology 188, no. 1_Supplement (2012): 52.18. http://dx.doi.org/10.4049/jimmunol.188.supp.52.18.

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Abstract We have generated tumor cell-based vaccines to activate patients’ CD4+ T-cells to facilitate tumor immunity. The vaccines are based on the hypothesis that invariant chain negative (Ii-), MHC II+ , CD80+ human breast cancer cells (MCF10) present novel MHC II peptides and circumvent patients’ tolerance to their cancer. We sequenced MHC II peptides from Ii- (MCF10/DR7/CD80 and MCF10/CIITA/CD80/Ii siRNA) and Ii+ (MCF10/DR7/CD80/Ii and MCF10/CIITA/CD80) cells using LC-MS/MS. 64/116 peptides identified were unique to MCF10/DR7/CD80 and 176/228 peptides were unique to MCF10/DR7/CD80/Ii cells

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Nanua, Suparna, and Fayth K. Yoshimura. "Mink Epithelial Cell Killing by Pathogenic Murine Leukemia Viruses Involves Endoplasmic Reticulum Stress." Journal of Virology 78, no. 21 (2004): 12071–74. http://dx.doi.org/10.1128/jvi.78.21.12071-12074.2004.

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ABSTRACT We previously demonstrated that mink cells undergo apoptosis after MCF13 murine leukemia virus (MLV) infection. In this study, we observed that virus-infected mink epithelial cells had significantly larger amounts of steady-state levels of MCF13 MLV envelope precursor protein (gPr80 env ) than did Mus dunni fibroblasts, which are resistant to virus-induced cytopathicity. Infection of mink cells with the noncytopathic NZB-9 MLV did not result in the accumulation of gPr80 env . MCF13 MLV infection of mink cells produced low cell surface expression of envelope glycoprotein and less effic

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Nakano, Masataka, Takuya Furuichi, Masahiro Sokabe, Hidetoshi Iida, Sachiko Yano, and Hitoshi Tatsumi. "Entanglement of Arabidopsis Seedlings to a Mesh Substrate under Microgravity Conditions in KIBO on the ISS." Plants 11, no. 7 (2022): 956. http://dx.doi.org/10.3390/plants11070956.

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The International Space Station (ISS) provides a precious opportunity to study plant growth and development under microgravity (micro-G) conditions. In this study, four lines of Arabidopsis seeds (wild type, wild-type MCA1-GFP, mca1-knockout, and MCA1-overexpressed) were cultured on a nylon lace mesh placed on Gelrite-solidified MS-medium in the Japanese experiment module KIBO on the ISS, and the entanglement of roots with the mesh was examined under micro-G and 1-G conditions. We found that root entanglement with the mesh was enhanced, and root coiling was induced under the micro-G condition.

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Aoki, Sadao, Jun Takizawa, Yoshinobu Seki, et al. "Micafungin Is Extremely Effective Against Fungal Infections Complicating Hematological Malignancies: Report of a Multicenter Study by N-FISH (Niigata Fungal Infection Study Group in Hematology)." Blood 106, no. 11 (2005): 5350. http://dx.doi.org/10.1182/blood.v106.11.5350.5350.

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Abstract [Background]Micafungin (MCFG) is a candin antifungal agent, and was marketed in Dec. 2002 in Japan and in Apr. 2005 in the United States. The Niigata Fungal Infection Study Group in Hematology (N-FISH) performed a multicenter prospective study to clarify the therapeutic effects of MCFG on deep fungal infections complicating hematological malignancies. [Methods]A total of 36 pts. who had been treated in centers belonging to N-FISH between Oct. 2003 and Apr. 2005 were included in this study. They consisted of 14 men and 22 women with a mean age of 53.5 years: 14 pts. with AML, 10 pts. w

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Thomas, Lori L., Ashley Hartman, Jason C. Woodworth, et al. "138 Evaluation of different combinations of medium chain fatty acids and monolaurin as a dietary additive for nursery pigs." Journal of Animal Science 97, Supplement_2 (2019): 80–81. http://dx.doi.org/10.1093/jas/skz122.146.

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Abstract A total of 360 pigs (DNA 400×200, initial BW=6.8 kg) were used a 35-d trial to evaluate the effects of adding MCFA and monolaurin blends to the diet on growth performance of nursery pigs. Pens of pigs were blocked by BW and randomized to 1 of 6 dietary treatments (12 pens per treatment). Treatments consisted of a basal diet containing no MCFA (control), the control diet with 1.0% added MCFA (a 1:1:1 blend of C6, C8, and C10; Sigma Aldrich, St. Louis, MO), or a 1.0% inclusion of 4 different blends of MCFA, lactic acid, and monolaurin (1, 2, 3, and 4). The 4 blends consisted of 50% C6,

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Moran, Kory, Jan Dirk van der Klis, Glen Almond, and Eric van Heugten. "PSVI-11 Evaluation of essential oils and short-medium chain fatty acids in-vitro and in-vivo on performance of nursery pigs." Journal of Animal Science 97, Supplement_2 (2019): 207. http://dx.doi.org/10.1093/jas/skz122.364.

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Abstract This study evaluated the anti-bacterial effects of two essential oils blends (EO1: garlic-derived allyl disulfide+d-limonene; EO2: garlic-derived allyl disulfide+γ-terpinene) and three mixtures of short-medium chain fatty acids (S-MCFA1: monolaurin enriched+C4-C12 mixture; S-MCFA2: monolaurin; S-MCFA3: monobutyrin enriched+C4-C12 mixture). In Exp. 1, the Minimum Inhibitory Concentration test (MIC; broth microdilution method using CLSI Guidelines) determined the in-vitro synergistic activity of six combinations: 1) EO1+S-MCFA1; 2) EO1+S-MCFA2; 3) EO1+S-MCFA3; 4) EO2+S-MCFA1; 5) EO2+S-M

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