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Journal articles on the topic 'Mcgrail'

Author: Grafiati

Published: 4 June 2021

Last updated: 27 July 2025

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1

McGrail, Carmen France. "Ensuring kidney patients and their families stay well during the winter." Journal of Kidney Care 7, no. 1 (2022): 40–41. http://dx.doi.org/10.12968/jokc.2022.7.1.40.

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2

van der Merwe, Pieter. "Seán McGrail (1928–2021)." Mariner's Mirror 107, no. 4 (2021): 390–92. http://dx.doi.org/10.1080/00253359.2021.1978253.

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3

CROOME, ANGELA. "Ancient Boats and Ships - by Seán McGrail." International Journal of Nautical Archaeology 36, no. 1 (2007): 196–97. http://dx.doi.org/10.1111/j.1095-9270.2007.140_2.x.

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4

Duran, Leandro Domingues. "Arqueologia Subaquática ou Arqueologia Marítima?: definindo conceitos, contextualizando práticas e assumindo posições." Vestígios - Revista Latino-Americana de Arqueologia Histórica 6, no. 2 (2012): 10–34. http://dx.doi.org/10.31239/vtg.v6i2.10628.

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Este artigo explora as diferenças existentes entre os conceitos de "Arqueologia Subaquática" e "Arqueologia Marítima", entendendo-se enquanto fruto de propostas interconectadas, porém distintas. Partindo de uma análise histórica sobre o desenvolvimento da relação entre a prática do mergulho e a fundação de uma "arqueologia dos ambientas aquáticos", tomamos como base as proposições inicialmente desenvolvidas pelo arqueólogo Keith Muckelroy no final dos anos de 1970 e discutimos posicionamento mais recentes formulados por autores como David Gibbins, Sean McGrail e Jonathan Adams, para desenvolve

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5

Süer, Sonat. "On subgroups of the additive group in differentially closed fields." Journal of Symbolic Logic 77, no. 2 (2012): 369–91. http://dx.doi.org/10.2178/jsl/1333566628.

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AbstractIn this paper we deal with the model theory of differentially closed fields of characteristic zero with finitely many commuting derivations. First we observe that the only known lower bound for the Lascar rank of types in differentially closed fields, announced in a paper of McGrail, is false. This gives us a new class of regular types which are orthogonal to fields. Then we classify the subgroups of the additive group of Lascar rank omega with differential-type 1 which are nonorthogonal to fields. The last parts consist of an analysis of the quotients of the heat variety. We show that

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Hashmi, N. "Implementing Multi-Media as a Pedagogical Tool in an EFL classroom: Benefits and Barriers." Journal of Arts and Humanities 5, no. 9 (2016): 13. http://dx.doi.org/10.18533/journal.v5i9.999.

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<p>The implementation of computer technologies especially the use of multimedia and internet in Saudi Arabian education system has attracted Arab students a lot. They have shown great interest in using computers technology for foreign language learning because computer technologies have transformed their contemporary society, changing the way they live, work and learn. As a response to such societal transformation, computer technologies have been brought into classrooms where they are considered to be effective in enhancing students learning and addressing certain education problems (McG

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7

Westerdahl, Christer. "The trireme-an experimental form?:An answer to Sean McGrail in IJNA 21.3." International Journal of Nautical Archaeology 22, no. 3 (1993): 205–6. http://dx.doi.org/10.1111/j.1095-9270.1993.tb00412.x.

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8

Colberg, Kristin. "The Rite of Christian Initiation: Adult Rituals and Roman Catholic Ecclesiology by Peter McGrail." Antiphon: A Journal for Liturgical Renewal 21, no. 2 (2017): 181–83. http://dx.doi.org/10.1353/atp.2017.0016.

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9

Flatman, Joe. "Nigel Nayling and Seán McGrail, The Barland’s Farm Romano-Celtic Boat (CBA Research Report 138)." Journal of Maritime Archaeology 2, no. 1 (2007): 61–62. http://dx.doi.org/10.1007/s11457-007-9014-6.

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10

Cronshaw, Darren. "Together for the Common Good: Towards a National Conversation, written by Nicholas Sagovsky and Peter McGrail." International Journal of Public Theology 9, no. 4 (2015): 485–87. http://dx.doi.org/10.1163/15697320-12341421.

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11

de Courcy Ireland, John. "Seán McGrail, Ancient boats in N. W. Europe: the archaeology of water transport to 1500 A. D." Peritia 8 (January 1994): 239–40. http://dx.doi.org/10.1484/j.peri.3.223.

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12

Kaundal, Babita, Daniel J. McGrail, Yang Li, et al. "Abstract 3344: Widespread BRCA1/2-independent homologous recombination defects are caused by alterations in RNA binding proteins." Cancer Research 84, no. 6_Supplement (2024): 3344. http://dx.doi.org/10.1158/1538-7445.am2024-3344.

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Abstract Summary: Defects in homologous recombination DNA repair (HRD) both predispose to cancer development and produce therapeutic vulnerabilities, making it critical to define the spectrum of genetic events that cause HRD. However, we found that mutations in BRCA1/2 and other canonical HR genes only identified 10-20% of tumors that display genomic evidence of HRD. Using a networks-based approach, we discovered that over half of putative genes causing HRD originated outside of canonical DNA damage response genes, with a particular enrichment for RNA binding protein (RBP)-encoding genes. Thes

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McGrail, Maura, Fang Liu, Sekhar Kambakam, and Zhitao Ming. "Abstract PR-010: Asc1lb progenitor-specific RB conditional inactivation in zebrafish models rare CNS primitive neuroectodermal tumors." Cancer Research 84, no. 5_Supplement_1 (2024): PR—010—PR—010. http://dx.doi.org/10.1158/1538-7445.brain23-pr-010.

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Abstract We generated a new zebrafish model of human brain cancer by Cre/lox regulated conditional inactivation of the tumor suppressor RB in embryonic neural progenitors. An ascl1b progenitor Cre driver was used to inactivate RB by Cre recombination of an intronic floxed mRFP gene trap cassette, leading to mRFP expression and lineage labeling of RB mutated cells. Beginning at 6 months of age adult fish developed poorly differentiated brain tumors, similar to our previous zebrafish brain tumor model generated by CRISPR targeting of RB in embryos. Tumor transcriptome analysis revealed a proneur

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14

Polinski, Jennifer M., and Joshua D. Voss. "Evidence of photoacclimatization at mesophotic depths in the coral-Symbiodinium symbiosis at Flower Garden Banks National Marine Sanctuary and McGrail Bank." Coral Reefs 37, no. 3 (2018): 779–89. http://dx.doi.org/10.1007/s00338-018-1701-2.

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15

Kramer, Michael J. "Review: People, Practice, Power: Digital Humanities Outside the Center, edited by Anne B. McGrail, Angel David Nieves, and Siobhan Senier." Afterimage 49, no. 3 (2022): 107–11. http://dx.doi.org/10.1525/aft.2022.49.3.107.

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16

Li, Yang, Daniel J. McGrail, Sharad Awasthi, S. Stephen Yi, Mark T. Bedford, and Nidhi Sahni. "Abstract LB182: Targeting arginine methylation for improved therapy in triple negative breast cancer." Cancer Research 83, no. 8_Supplement (2023): LB182. http://dx.doi.org/10.1158/1538-7445.am2023-lb182.

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Abstract Since the discovery of DNA repair deficiency as risk factors for breast cancer, our knowledge of their function in maintaining human genomic integrity and a normal biological function has greatly advanced, ultimately culminating in development of PARP inhibitors that can specifically target patients who harbor these mutations. However, to date PARP inhibitors have demonstrated only modest clinical success as monotherapy in triple-negative breast cancer. In addition, conventional therapies are often coupled with severe toxicity. Therefore, there is a dire need to develop more effective

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17

Awasthi, Sharad, Daniel J. McGrail, S. Stephen Yi, and Nidhi Sahni. "Abstract LB427: UBA1 blockade induces homologous recombination deficiency and is synthetic lethal with PARP inhibition." Cancer Research 84, no. 7_Supplement (2024): LB427. http://dx.doi.org/10.1158/1538-7445.am2024-lb427.

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Abstract Therapeutic strategies targeting DNA damage have revolutionized cancer treatment, yet their efficacy often comes at the cost of substantial adverse effects. The emergence of poly-ADP-ribose polymerase (PARP) inhibition as a targeted approach to disrupt DNA repair in tumors deficient in homologous recombination (HR) has shown promise. However, the limited response of most cancers to PARP inhibitors has posed a significant challenge. This study employs a genome-wide CRISPR knockout functional genomics screen, revealing that depletion of ubiquitin-activating enzyme E1 (UBA1) enhances sen

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18

Zhao, Mei, Tianxiao Wang, Frederico O. Gleber-Netto, et al. "Abstract 2585: Mutant p53 gains oncogenic functions through a cytosolic DNA response." Cancer Research 83, no. 7_Supplement (2023): 2585. http://dx.doi.org/10.1158/1538-7445.am2023-2585.

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Abstract TP53 mutations are the most common cancer driver mutations among all cancers. Although some TP53 mutations lead to a loss of function of wild-type p53, many other TP53 mutations confer gain-of-function (GOF) activities, which promote cancer cell metastasis and pro-tumorigenic inflammation. Despite that many functional models of GOF mutant p53 (mutp53) have been proposed previously, the mechanisms involved in mutp53 GOF still remain largely elusive. Here we show that by directly targeting minichromosome maintenance complex component 5 (MCM5), a component of the hexametric DNA helicase

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19

Awasthi, Sharad, S. Stephen Yi, Daniel J. McGrail, and Nidhi Sahni. "Abstract LB043: Pharmacological inhibition of ubiquitination sensitizes to DNA damaging agents by preventing homologous recombination repair." Cancer Research 83, no. 8_Supplement (2023): LB043. http://dx.doi.org/10.1158/1538-7445.am2023-lb043.

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Abstract Therapies inducing DNA damage have been the backbone of cancer treatment for decades, but they often cause significant adverse effects reducing quality of life. Recently, inhibition of poly-ADP-ribose polymerase (PARP) has been shown to target tumor cells with deficient DNA homologous recombination (HR) double-strand break repair by converting single-strand DNA breaks into toxic double-strand breaks that cannot be resolved. This approach has been advantageous as healthy cells with functional HR repair are less effective, resulting in a more tolerable treatment. However, most cancers w

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20

Agrawal, Anjali, Daniel McGrail, Nidhi Sahni, and S. Stephen Yi. "Abstract 858: A functional atlas of cancer mutation-rewired protein interactome networks." Cancer Research 84, no. 6_Supplement (2024): 858. http://dx.doi.org/10.1158/1538-7445.am2024-858.

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Abstract Somatic mutations in cancer can exert effects on protein-protein interactions (PPIs), leaving some wild-type (WT) interactions perturbed while others unperturbed. The type of PPI perturbations can be used to link the mutation to its phenotypic effects. Here, we apply a technique known as functional variomics to characterize PPI profile changes for around 1,000 cancer missense mutations. Remarkably, our results reveal 5 distinct classes (edgotypes) of mutations: mutations losing PPIs compared to WT (edgetic), gaining PPIs (gain), gaining & losing PPIs (gain/loss), losing all PPIs (

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21

Sanders, Damien. "The Dover Boat; Some Responses to Ole Crumlin-Pedersen and Seán McGrail Concerning its Propulsion, Hull-Form, and Assembly, and Some Observations on the Reappraisal Process." International Journal of Nautical Archaeology 36, no. 1 (2007): 184–92. http://dx.doi.org/10.1111/j.1095-9270.2007.00138.x.

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22

Power, Maria. "Together for the Common Good: Towards a National Conversation, Nicholas Sagovsky and Peter McGrail (eds), SCM, 2015, (ISBN 978-0-334053248), xxx + 212 pp., pb £25." Reviews in Religion & Theology 23, no. 1 (2016): 72–74. http://dx.doi.org/10.1111/rirt.12596.

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23

McCartin, James P. "The Rite of Christian Initiation: Adult Rituals and Roman Catholic Ecclesiology. By Peter McGrail . Liturgy, Worship and Society. Burlington, Vt.: Ashgate, 2013. xii + 217 pp. $75.00 cloth." Church History 85, no. 3 (2016): 635–37. http://dx.doi.org/10.1017/s0009640716000597.

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24

Noort, Robert Van De. "Boats of the World. From the Stone Age to Medieval Times. By Seán McGrail. 290mm. Pp xi plus 480, ills. Oxford: Oxford University Press, 2001. ISBN 0198144687. £120." Antiquaries Journal 82 (September 2002): 368–69. http://dx.doi.org/10.1017/s0003581500073935.

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25

Liscoe, Stephen. "Early Ships and Seafaring: water transport beyond Europe SEÁN McGRAIL 220pp, 88 b&w photographs, illustrations and tables, Pen & Sword Books, £19.99 (hbk), ISBN 978-1473825598." International Journal of Nautical Archaeology 46, no. 1 (2017): 216–18. http://dx.doi.org/10.1111/1095-9270.12222.

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26

Perlee, Sarah, Yilun Ma, Jacob Swanson, et al. "Abstract 6621: Development of a melanocyte lineage-specific knockout system in zebrafish." Cancer Research 84, no. 6_Supplement (2024): 6621. http://dx.doi.org/10.1158/1538-7445.am2024-6621.

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Abstract Zebrafish have emerged as an ideal model organism for investigating melanocyte and melanoma biology. While CRISPR-Cas9 technology has significantly advanced our understanding of gene functions in zebrafish, two challenges remain: 1) how do we knock out embryonic lethal genes in adult melanocytes? and 2) how do we knock out tumor promoting genes (rather than tumor suppressors)? To address this, we have developed a new transgenic line in which Cas9 is knocked into the melanocyte-specific endogenous mitfa locus. To test this system in normal melanocytes, Tg(mitfa:Cas9) embryos were injec

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27

Kerr, Travis D., Patrick G. Pilie, Hui Dai, et al. "Abstract 7126: Divergent molecular features associated with immune checkpoint blockade response." Cancer Research 85, no. 8_Supplement_1 (2025): 7126. https://doi.org/10.1158/1538-7445.am2025-7126.

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Abstract The advent of immune checkpoint blockade (ICB) has revolutionized cancer management. However, not all patients will benefit from this powerful therapy, necessitating clinical biomarkers and combination treatment strategies to enhance therapeutic efficacy. Recently, high tumor mutation burden (TMB-H) was FDA-approved as a pan-cancer biomarker for treatment with ICB based on a limited sample size and diversity of tumors. In systematic analysis across cancer types, we observed that immune cell infiltration was only associated with TMB in a subset of cancers. Based on this, we divided can

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28

Greenhill, Basil. "Seán McGrail. Ancient boats in NW Europe: the archaeology of water transport to AD 1500. London & New York: Longmans, 1987. xxii + 321 pages, 177 illustrations. £45 & $79.95 hardback." Antiquity 61, no. 233 (1987): 483–84. http://dx.doi.org/10.1017/s0003598x00073191.

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29

WESTERDAHL, C. "(BAR British series 256)Sean McGrail, Studies in Maritime Archaeology £53, BAR, Oxford via Hadrian Books, Fort Cumberland, Fort Cumberland Road, Portsmouth PO4 9LD (1997) 0-86053-903-8 £53." International Journal of Nautical Archaeology 27, no. 4 (1998): 363–65. http://dx.doi.org/10.1016/s1057-2414(98)80010-1.

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30

van de Noort, Robert. "The Borland's Farm Romano-Celtic Boat. By Nigel Nayling and Seán McGrail. 300mm. Pp xxi + 327, ills. York: Council for British Archaeology Research Report 138, 2004. ISBN 1902771400. £30 (pbk)." Antiquaries Journal 86 (September 2006): 419. http://dx.doi.org/10.1017/s0003581500000329.

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31

Bisht, Deepa, Yang Li, Lacey E. Dobrolecki, et al. "Abstract 3371: PRMT blockade induces defective DNA replication stress response via ATR suppression and synergizes with PARP inhibition." Cancer Research 84, no. 6_Supplement (2024): 3371. http://dx.doi.org/10.1158/1538-7445.am2024-3371.

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Abstract Aberrant protein arginine methylation has been observed in multiple cancer types, making it an attractive drug target. Proteins can undergo asymmetric arginine methylation by type I protein arginine methyltransferases (PRMTs), predominately by PRMT1 and to a lesser extent PRMT4, or symmetric arginine methylation by type II PRMTs, predominately PRMT5. Here, we performed targeted proteomics following inhibition of PRMT1, PRMT4, and PRMT5 across cancer cell lines. We found that inhibition of both type I and type II PRMTs suppressed levels of total and phosphorylated ATR protein in cancer

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32

Shelden, E., and P. Wadsworth. "Observation and quantification of individual microtubule behavior in vivo: microtubule dynamics are cell-type specific." Journal of Cell Biology 120, no. 4 (1993): 935–45. http://dx.doi.org/10.1083/jcb.120.4.935.

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Recent experiments have demonstrated that the behavior of the interphase microtubule array is cell-type specific: microtubules in epithelial cells are less dynamic than microtubules in fibroblasts (Pepper-kok et al., 1990; Wadsworth and McGrail, 1990). To determine which parameters of microtubule dynamic instability behavior are responsible for this difference, we have examined the behavior of individual microtubules in both cell types after injection with rhodamine-labeled tubulin subunits. Individual microtubules in both cell types were observed to grow, shorten, and pause, as expected. The

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33

Greenhill, Basil. "Aspects of Maritime Archaeology and Ethnography. Edited by Sean McGrail. 21 × 15 cm. Pp. 226, 90 ills. London: National Maritime Museum, 1984. ISBN 0-905555-74-0. £7·50 (p/b)." Antiquaries Journal 66, no. 1 (1986): 135. http://dx.doi.org/10.1017/s0003581500084572.

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Pilie, Patrick G., Lijun Zhou, Yan-Ting Zhang, et al. "Abstract LB039: VHL-deficient renal cell carcinoma displays defective ATM activation and sensitivity to ATR inhibition." Cancer Research 82, no. 12_Supplement (2022): LB039. http://dx.doi.org/10.1158/1538-7445.am2022-lb039.

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Abstract Introduction: Clear cell renal cell carcinoma (ccRCC) displays genomic instability, but lacks mutations in canonical DNA damage response (DDR) genes. Bi-allelic loss of VHL is a near ubiquitous, truncal event in ccRCC development. Herein, we performed preclinical and clinical analysis to understand how VHL loss impacts DDR pathway activity and how specific DDR deficiencies (DDR-D) may be targeted in ccRCC. Methods: We performed DNA whole exome sequencing (WES) and reverse phase protein array (RPPA) early stage ccRCC tumors. All patients were consented under an IRB-approved protocol fo

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Pilie, Patrick G., Daniel Mcgrail, Wei-Lien Wang, et al. "Abstract 3432: Ataxia-telangiectasia mutated loss of function displays variant and tissue specific differences across tumor types." Cancer Research 83, no. 7_Supplement (2023): 3432. http://dx.doi.org/10.1158/1538-7445.am2023-3432.

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Abstract Introduction: ATM loss of function (LOF) in cancer may serve as a predictive biomarker of response for antitumor therapies. However, clinical studies of targeted treatments in ATM-aberrant patients have yielded mixed results; thus, identifying the optimal strategy for selecting patients with ATM LOF tumors remains a critical area of unmet need. Methods: In order to investigate the heterogeneity observed in ATM aberrant tumors, we conducted a pan-cancer genomic and proteomic profiling of ATM LOF, and also performed retrospective review of clinical outcomes for a subset of patients with

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Liu, Xiande, Yanting Zhang, Xuesong Zhang, et al. "Abstract 4153: SETD2 loss and ATR inhibition synergistically promote cGAS signaling and immunotherapy response in renal cell carcinoma." Cancer Research 83, no. 7_Supplement (2023): 4153. http://dx.doi.org/10.1158/1538-7445.am2023-4153.

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Abstract Rationale: Immune checkpoint blockade (ICB) demonstrates durable clinical benefit only in a minority of renal cell carcinoma (RCC) patients. Identifying molecular features that determine response and developing approaches to enhance the response remain an urgent clinical need. Targeting S phase DNA damage repair (S-DDR) network has been reported to activate cGAS signaling and convert a non-immunogenic tumor microenvironment to an immunogenic tumor microenvironment, thus improving immunotherapy response in breast cancer and small cell lung cancer. SETD2 has been known to be required fo

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Scoffin, T. P. "Reefs and banks of the Northwestern Gulf of Mexico by R. Rezak T. J. Bright and D. W. McGrail, Wiley, New York, 1985. No. of pages: 259. Price: £54.25 (hardback). ISBN 471 89379 X." Geological Journal 21, no. 4 (1986): 425–26. http://dx.doi.org/10.1002/gj.3350210408.

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Parker, A. J. "The Barland's Farm Romano-Celtic Boat. By N. Nayling and S. McGrail. Council for British Archaeology Research Report 138. Council for British Archaeology, York, 2004. Pp. 327, illus. Price: £30.00. ISBN 1 902771 40 0." Britannia 37 (November 2006): 513–14. http://dx.doi.org/10.1017/s0068113x00002099.

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Christensen, Arne Emil. "Early Ships and Seafaring: European water transport SEAN McGRAIL 192 pp., b&w drawings and photographs Pen and Sword Archaeology, 47 Church Street, Barnsley, South Yorkshire, S70 2AS, 2014, £19.99 (hbk), ISBN 978-1781593929." International Journal of Nautical Archaeology 45, no. 2 (2016): 471. http://dx.doi.org/10.1111/1095-9270.12193.

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Galan-Cobo, Ana, Yu Qian, Fuduan Peng, et al. "Abstract 2113: Suppression of macrophage migration inhibitory factor (MIF) impairs tumor growth and overcomes immunotherapy resistance in KEAP1-deficient NSCLC tumors." Cancer Research 82, no. 12_Supplement (2022): 2113. http://dx.doi.org/10.1158/1538-7445.am2022-2113.

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Abstract Background: KEAP1, which regulates the degradation of the antioxidant transcription factor NRF2, is the third most commonly mutated tumor suppressor in lung adenocarcinoma (LUAD). Recent reports have provided clinical evidence that mutations in STK11/LKB1 and KEAP1 are strongly associated with immune checkpoint blockade resistance in LUAD, particularly those harboring KRAS mutations. Nevertheless, the specific mechanisms by which loss of KEAP1 impacts anti-tumor immunity in KRAS mutant tumors remains to be determined. Methods: KRAS-mutant (K) and LKB1 (KL), and/or KEAP1-deficient (KK

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Anh Nguyen, Thai Quynh, Daniel J. McGrail, Hui Dai, et al. "Abstract 4209: Targeting RNase H2: a dual mechanism strategy to elevate replication stress, DNA damage, and antitumor immunity in triple-negative breast cancer." Cancer Research 85, no. 8_Supplement_1 (2025): 4209. https://doi.org/10.1158/1538-7445.am2025-4209.

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Abstract The inhibition of Ribonuclease H2 (RNase H2) activity offers a promising therapeutic approach for suppressing tumor growth in triple-negative breast cancers (TNBCs) by elevating DNA replication stress, inducing DNA damage, inducing cell death, and enhancing sensitivity to immunotherapy. RNase H2, a key enzyme responsible for removing misincorporated ribonucleotides from the genome, plays a pivotal role in maintaining genomic integrity. Overexpression of the RNASEH2A gene, which encodes the catalytic subunit of the RNase H2 complex, has been observed in breast tumors, with the highest

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Mudie, Colin. "Boats of the World: From the Stone Age to Medieval Times. Seán McGrail. Oxford University Press, 2002. ISBN 0-19-814468-7. 496 pages, halftone and line drawings, 3 maps, 276×219 mm. 480 pages. Price £120." Journal of Navigation 55, no. 3 (2002): 507–9. http://dx.doi.org/10.1017/s0373463302222018.

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43

Rule, Margaret. "Ancient Boats in N.W. Europe. The Archaeology of Water Transport to A.D. 1500. By Sean McGrail. 25·5 × 19·4 cm. Pp. xx + 321, 181 figs. London: Longman (Longman Archaeology Series), 1987. ISBN 0-582-49267-X. £45." Antiquaries Journal 68, no. 2 (1988): 337–38. http://dx.doi.org/10.1017/s0003581500069651.

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Ruetzler, Kurt, Lukasz Szarpak, Jacek Smereka, et al. "Comparison of Direct and Video Laryngoscopes during Different Airway Scenarios Performed by Experienced Paramedics: A Randomized Cross-Over Manikin Study." BioMed Research International 2020 (February 18, 2020): 1–8. http://dx.doi.org/10.1155/2020/5382739.

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Introduction. Airway management plays an essential role in anaesthesia practice, during both elective and urgent surgery procedures and emergency medicine. Aim. The aim of the study was to compare Macintosh laryngoscope (MAC), McGrath, and TruView PCD in 5 separate airway management scenarios. Methods. This prospective cross-over simulation study involved 93 paramedics. All paramedics performed intubation using direct laryngoscope (MAC), McGrath, and TruView PCD video laryngoscopes. The study was performed in 5 different scenarios: (A) normal airway, (B) tongue oedema, (C) pharyngeal obstructi

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Mihara, Ryosuke, Nobuyasu Komasawa, Sayuri Matsunami, and Toshiaki Minami. "Comparison of Direct and Indirect Laryngoscopes in Vomitus and Hematemesis Settings: A Randomized Simulation Trial." BioMed Research International 2015 (2015): 1–6. http://dx.doi.org/10.1155/2015/806243.

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Background.Videolaryngoscopes may not be useful in the presence of hematemesis or vomitus. We compared the utility of the Macintosh laryngoscope (McL), which is a direct laryngoscope, with that of the Pentax-AWS Airwayscope (AWS) and McGRATH MAC (McGRATH), which are videolaryngoscopes, in simulated hematemesis and vomitus settings.Methods.Seventeen anesthesiologists with more than 1 year of experience performed tracheal intubation on an adult manikin using McL, AWS, and McGRATH under normal, hematemesis, and vomitus simulations.Results.In the normal setting, the intubation success rate was 100

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Gadek, Leszek, Lukasz Szarpak, Lars Konge, et al. "Direct vs. Video-Laryngoscopy for Intubation by Paramedics of Simulated COVID-19 Patients under Cardiopulmonary Resuscitation: A Randomized Crossover Trial." Journal of Clinical Medicine 10, no. 24 (2021): 5740. http://dx.doi.org/10.3390/jcm10245740.

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A safe way of securing the airway with an endotracheal tube is one of the priorities of an advanced cardiovascular life support algorithm for suspected or confirmed COVID-19 patients. The aim of this study was to compare intubation success rates (ISR) and intubation time (IT) of different laryngoscopes for simulated COVID-19 patients under cardiopulmonary resuscitation. The study was designed as a prospective, randomized, crossover trial. Fifty four active paramedics performed endotracheal intubation with a Macintosh direct laryngoscope (MAC) and McGrath videolaryngoscope (McGrath) with and wi

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Shah, Prerana N., and Kaveri Das. "McGrath Video Laryngoscope May Take a Longer Intubation Time Than Macintosh Laryngoscope." Journal of Anesthesiology 2015 (November 26, 2015): 1–4. http://dx.doi.org/10.1155/2015/901903.

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Background. Video laryngoscopes provide better view and can improve ease of intubation compared with standard laryngoscopes. Methods. A prospective randomized study was done on 60 patients, 18 to 65 years old, comparing McGrath video laryngoscope and Macintosh laryngoscope. The aim was to compare the ease, efficacy, and usability of them during routine airway management. The primary endpoint was duration of intubation and the secondary endpoints were Cormack and Lehane grade of laryngoscopic view, number of intubation attempts, and incidence of complications. Results. There was an increase in

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Le, Xiuning, Ruiping Wang, Natalie Vokes, et al. "Abstract 3260: Enhanced lineage plasticity in RTK-independent TKI-resistant EGFR-mutant NSCLC." Cancer Research 82, no. 12_Supplement (2022): 3260. http://dx.doi.org/10.1158/1538-7445.am2022-3260.

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Abstract Background: Resistance to targeted tyrosine kinase inhibitors (TKI) inevitably develops in metastatic EGFR-mutant non-small cell lung cancer (NSCLC). Resistance mechanisms are diverse, and mechanisms beyond receptor tyrosine kinase (RTK) pathway mutations are poorly understood. We hypothesized that the use of osimertinib as first-line therapy is increasing the prevalence of RTK-independent resistance mechanisms, and that RTK-independent resistant tumors undergo enhanced tumor cell lineage plasticity as an escape mechanism to EGFR TKI therapy. Methods: We identified patients who develo

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Yilmaz, Emrullah, Jacob A. Miller, Shlomo A. Koyfman, Jessica L. Geiger, Natalie Silver, and Daniel McGrail. "Abstract PO-028: Clinical and genomic correlates of intratumoral HPV for oropharyngeal and cervical cancers." Clinical Cancer Research 29, no. 18_Supplement (2023): PO—028—PO—028. http://dx.doi.org/10.1158/1557-3265.aacrahns23-po-028.

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Abstract Introduction: p16 immunohistochemistry (IHC) is the most commonly used test for diagnosing Human Papillomavirus (HPV) related oropharyngeal cancers. HPV DNA or RNA tests have been used increasingly more recently. However, the significance of the intratumoral HPV expression levels is not established yet. Here, we analyzed the intratumoral HPV expression levels using The Cancer Genome Atlas (TCGA) database. Methods: HPV levels were analyzed for oropharyngeal and cervical cancers using the TCGA database at cBioPortal.1,2 Alphapapilloma virus genus was included in the analysis to capture

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Silver, Natalie, David Hoying, Eric Lamarre, et al. "Abstract PO-090: Characterizing the intra-tumoral microbiome of laryngeal squamous cell carcinoma." Clinical Cancer Research 29, no. 18_Supplement (2023): PO—090—PO—090. http://dx.doi.org/10.1158/1557-3265.aacrahns23-po-090.

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Abstract Background: While the microbiome of oral squamous cell carcinoma has been intensely studied, little is known about the role of bacteria in laryngeal squamous cell carcinoma (LSCC). Our group recently demonstrated that pathogenic bacteria, such as Fusobacterium, are associated with oral cavity cancer and influence checkpoint ligand expression. To understand the potential role of bacteria in LSCC, we comprehensively profiled the intra-tumoral bacterial microbiome. Methods: DNA from tumor and adjacent normal tissue was isolated from formalin-fixed paraffin-embedded (FFPE) samples for 18

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