Academic literature on the topic 'MCHR1'
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Journal articles on the topic "MCHR1"
Chee, Melissa J. S., Pavlos Pissios, Deepthi Prasad, and Eleftheria Maratos-Flier. "Expression of Melanin-Concentrating Hormone Receptor 2 Protects Against Diet-Induced Obesity in Male Mice." Endocrinology 155, no. 1 (January 1, 2014): 81–88. http://dx.doi.org/10.1210/en.2013-1738.
Full textÅstrand, Annika, Mohammad Bohlooly-Y, Sara Larsdotter, Margit Mahlapuu, Harriet Andersén, Jan Tornell, Claes Ohlsson, Mike Snaith, and David G. A. Morgan. "Mice lacking melanin-concentrating hormone receptor 1 demonstrate increased heart rate associated with altered autonomic activity." American Journal of Physiology-Regulatory, Integrative and Comparative Physiology 287, no. 4 (October 2004): R749—R758. http://dx.doi.org/10.1152/ajpregu.00134.2004.
Full textFrancke, Felix, Richard J. Ward, Laura Jenkins, Elaine Kellett, Dietmar Richter, Graeme Milligan, and Dietmar Bächner. "Interaction of Neurochondrin with the Melanin-concentrating Hormone Receptor 1 Interferes with G Protein-coupled Signal Transduction but Not Agonist-mediated Internalization." Journal of Biological Chemistry 281, no. 43 (August 31, 2006): 32496–507. http://dx.doi.org/10.1074/jbc.m602889200.
Full textLim, Gyutae, Ka Young You, Jeong Hyun Lee, Moon Kook Jeon, Byung Ho Lee, Jae Yong Ryu, and Kwang-Seok Oh. "Identification and New Indication of Melanin-Concentrating Hormone Receptor 1 (MCHR1) Antagonist Derived from Machine Learning and Transcriptome-Based Drug Repositioning Approaches." International Journal of Molecular Sciences 23, no. 7 (March 30, 2022): 3807. http://dx.doi.org/10.3390/ijms23073807.
Full textBohlooly-Y, Mohammad, Margit Mahlapuu, Harriet Andersén, Annika Åstrand, Stephan Hjorth, Lennart Svensson, Jan Törnell, Michael R. Snaith, David G. Morgan, and Claes Ohlsson. "Osteoporosis in MCHR1-deficient mice." Biochemical and Biophysical Research Communications 318, no. 4 (June 2004): 964–69. http://dx.doi.org/10.1016/j.bbrc.2004.04.122.
Full textPałasz, Artur, Aneta Piwowarczyk-Nowak, Aleksandra Suszka-Świtek, Katarzyna Bogus, Łukasz Filipczyk, Alessandra Della Vecchia, Kinga Mordecka-Chamera, et al. "Escitalopram as a modulator of proopiomelanocortin, kisspeptin, Kiss1R and MCHR1 gene expressions in the male rat brain." Molecular Biology Reports 47, no. 10 (September 10, 2020): 8273–78. http://dx.doi.org/10.1007/s11033-020-05806-8.
Full textVetlugin, Eduard A., Eugenii R. Bychkov, Maxim E. Abrosimov, Alexandr R. Moskalyev, Anna G. Pshenichnaya, Sarng S. Pyurveev, Victor A. Lebedev, Andrei A. Lebedev, and Petr D. Shabanov. "Anxiolytic and antidepressant effects of melanin-concentrating hormone 1 receptor antagonist SNAP 94847." Pediatrician (St. Petersburg) 13, no. 1 (May 31, 2022): 25–34. http://dx.doi.org/10.17816/ped13125-34.
Full textAndersen, Denise, Thomas Storz, Pingli Liu, Xin Wang, Leping Li, Pingchen Fan, Xiaoqi Chen, et al. "Stereoselective Synthesis of a MCHr1 Antagonist." Journal of Organic Chemistry 72, no. 25 (December 2007): 9648–55. http://dx.doi.org/10.1021/jo701894v.
Full textWermter, Anne-Kathrin, Kathrin Reichwald, Thomas Büch, Frank Geller, Cornelia Platzer, Klaus Huse, Claudia Hess, et al. "Mutation analysis of the MCHR1 gene in human obesity." European Journal of Endocrinology 152, no. 6 (June 2005): 851–62. http://dx.doi.org/10.1530/eje.1.01917.
Full textBerbari, Nicolas F., Andrew D. Johnson, Jacqueline S. Lewis, Candice C. Askwith, and Kirk Mykytyn. "Identification of Ciliary Localization Sequences within the Third Intracellular Loop of G Protein-coupled Receptors." Molecular Biology of the Cell 19, no. 4 (April 2008): 1540–47. http://dx.doi.org/10.1091/mbc.e07-09-0942.
Full textDissertations / Theses on the topic "MCHR1"
Schaller, David Andreas [Verfasser]. "Synergistic Target Combinations Against Obesity: Focus on MCHR1/H3R Modulation / David Andreas Schaller." Berlin : Freie Universität Berlin, 2020. http://d-nb.info/1215099746/34.
Full textAppl, Thomas. "Neurochemical and functional characterisation of the melanin concentrating hormone system in the rat brain." Phd thesis, [S.l.] : [s.n.], 2007. http://opus.kobv.de/ubp/volltexte/2007/1460.
Full textThody, Anthony J., Martin J. Hoogduijn, Janis Ancans, Siân E. Estdale, and I. Suzuki. "Melanin-concentrating hormone and its receptor are expressed and functional in human skin." 2009. http://hdl.handle.net/10454/2739.
Full textIn this study, we have demonstrated the presence of melanin-concentrating hormone (MCH) and melanin-concentrating hormone receptor (MCHR1) transcripts in human skin. Sequence analysis confirmed that the transcripts of both genes were identical to those previously found in human brain. In culture, endothelial cells showed pro-MCH expression whereas no signal was found in keratinocytes, melanocytes, and fibroblasts. MCHR1 expression was restricted to melanocytes and melanoma cells. Stimulation of cultured human melanocytes with MCH reduced the ¿-MSH-induced increase in cAMP production. Furthermore, the melanogenic actions of ¿-MSH were inhibited by MCH. We propose that the MCH/MCHR1 signalling system is present in human skin and may have a role with the melanocortins in regulating the melanocyte.
Kamba, Tisianna K. "Assessing neuronal ciliary localization of Melanin Concentrating Hormone Receptor 1 in vivo." Thesis, 2021. http://dx.doi.org/10.7912/C2/78.
Full textObesity is a growing pandemic that claims close to three hundred thousand lives per year in the United States alone. Despite strong interest and investment in potential treatments, obesity remains a complex and challenging disorder. In the study of obesity, mouse models have been excellent tools that help in understanding the function of different genes that contribute to this disease of energy homeostasis. However, it was surprising when disfunction in primary cilia was found to be linked to syndromic obesity. To understand the role of primary cilia in obesity, a growing subset of GPCRs have been identified to selectively localize to the organelle. Several of which have known roles in energy homeostasis. In some examples, ciliary GPCRs appear to dynamically localize to the organelle; such is the case of GPR161 and smoothened in the hedgehog signaling pathway. Thus, we were interested to see if other GPCRs dynamically localize to the primary cilia as part of their regulation of energy homeostasis. For example, the GPCR MCHR1 selectively localizes to the cilia and is involved in energy homeostasis. Although much is known about the expression of the receptor in the brain, how its ciliary subcellular localization impacts its roles in energy homeostasis is unknown. Observing neuronal cilia in vivo remains a difficult task as some of the available tools such as tagged alleles rely on overexpression of ciliary protein which may impact function. Additionally, most of the work is done in vitro, leaving much to be discovered about neuronal cilia in vivo. In this thesis, we show that using a newly constructed reporter allele mCherryMCHR1, we can see ciliary expression of MCHR1 in the brain of developing and adult mice; more specifically in the ARC and PVN. Subsequently, using a novel Artificial intelligence analysis approach, we measured the length and composition of MCHR1 positive cilia under physiological conditions associated with MCHR1 function. Although in this work we are reporting no changes in dynamic localization of MCHR1 in the hypothalamus specifically, we are not excluding the potential for changes in other regions of the brain or under other conditions; and we are suggesting that pharmacological approaches may help highlight potential ciliary GPCR dynamic localization.
Plamondon, Pascale. "Identification and characterization of a novel two-partner secretion system in Moraxella catarrhalis composed of MCHA1, MCHA2, and MCHB." 2008. http://proquest.umi.com/pqdweb?did=1546808251&sid=8&Fmt=2&clientId=39334&RQT=309&VName=PQD.
Full textTitle from PDF title page (viewed on Dec. 4, 2008) Available through UMI ProQuest Digital Dissertations. Thesis adviser: Campagnari, Anthony A. Includes bibliographical references.
Books on the topic "MCHR1"
More sourcesBook chapters on the topic "MCHR1"
Hamamoto, Akie, Yuki Kobayashi, and Yumiko Saito. "Melanin-Concentrating Hormone Receptor 1 (MCHR1)." In Encyclopedia of Signaling Molecules, 3075–82. Cham: Springer International Publishing, 2018. http://dx.doi.org/10.1007/978-3-319-67199-4_101710.
Full textHamamoto, Akie, Yuki Kobayashi, and Yumiko Saito. "Melanin-Concentrating Hormone Receptor 1 (MCHR1)." In Encyclopedia of Signaling Molecules, 1–8. New York, NY: Springer New York, 2016. http://dx.doi.org/10.1007/978-1-4614-6438-9_101710-1.
Full textSingh, Nivedita, M. Balasubramaniam, and Jitendra Singh. "Speech Recognition for Medical Conversations Health Record (MCHR)." In Proceedings of Emerging Trends and Technologies on Intelligent Systems, 191–201. Singapore: Springer Singapore, 2021. http://dx.doi.org/10.1007/978-981-16-3097-2_16.
Full text"MCHR1." In Encyclopedia of Signaling Molecules, 3020. Cham: Springer International Publishing, 2018. http://dx.doi.org/10.1007/978-3-319-67199-4_102213.
Full textPhilippe, Cécile, and Markus Mitterhauser. "The Potential Role of the MCHR1 in Diagnostic Imaging: Facts and Trends." In Melanin. InTech, 2017. http://dx.doi.org/10.5772/67185.
Full text"MCH1R." In Encyclopedia of Signaling Molecules, 3020. Cham: Springer International Publishing, 2018. http://dx.doi.org/10.1007/978-3-319-67199-4_102212.
Full textOh, Kean T., and Kent Small. "North Carolina Macular Dystrophy/Mcdr1." In Genetic Diseases of the Eye, 421–25. Oxford University Press, 2012. http://dx.doi.org/10.1093/med/9780195326147.003.0027.
Full text"Marriage by Cohabitation with Habit and Repute: Review And Requiem?" In Continuity, Influences and Integration in Scottish Legal History, edited by Hector L. MacQueen, 191–215. Edinburgh University Press, 2021. http://dx.doi.org/10.3366/edinburgh/9781474488761.003.0010.
Full textConference papers on the topic "MCHR1"
Li, Haifeng, Xiaoxia Yang, and Yiqiang Ouyang. "MCHRC: Min-Conflict Heuristic Based Web Services Chain Reconfiguration Approach." In 2009 International Conference on Computational Intelligence and Software Engineering. IEEE, 2009. http://dx.doi.org/10.1109/cise.2009.5365664.
Full textNowakowski, Kevin E., Jithma P. Abeykoon, Mary J. Stenson, Michael M. Timm, Curtis A. Hanson, Daniel L. Van Dyke, Anne J. Novak, Xiaosheng Wu, and Thomas E. Witzig. "Abstract 650: MCIR1: A patient-derived ibrutinib-resistant mantle cell lymphoma line for the study of ibrutinib resistance and drug discovery." In Proceedings: AACR Annual Meeting 2020; April 27-28, 2020 and June 22-24, 2020; Philadelphia, PA. American Association for Cancer Research, 2020. http://dx.doi.org/10.1158/1538-7445.am2020-650.
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