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Journal articles on the topic 'MCM paradox'

Author: Grafiati

Published: 4 June 2021

Last updated: 18 February 2022

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1

Das, Mitali, Sunita Singh, Satyajit Pradhan, and Gopeshwar Narayan. "MCM Paradox: Abundance of Eukaryotic Replicative Helicases and Genomic Integrity." Molecular Biology International 2014 (October 19, 2014): 1–11. http://dx.doi.org/10.1155/2014/574850.

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As a crucial component of DNA replication licensing system, minichromosome maintenance (MCM) 2–7 complex acts as the eukaryotic DNA replicative helicase. The six related MCM proteins form a heterohexamer and bind with ORC, CDC6, and Cdt1 to form the prereplication complex. Although the MCMs are well known as replicative helicases, their overabundance and distribution patterns on chromatin present a paradox called the “MCM paradox.” Several approaches had been taken to solve the MCM paradox and describe the purpose of excess MCMs distributed beyond the replication origins. Alternative functions

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2

De Schutter, Alban, Carl J. Lavie, Dharmendrakumar A. Patel, and Richard V. Milani. "Obesity paradox and the heart." Current Opinion in Clinical Nutrition and Metabolic Care 16, no. 5 (2013): 517–24. http://dx.doi.org/10.1097/mco.0b013e328363bcca.

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3

Ades, Philip A., and Patrick D. Savage. "The Obesity Paradox: Perception vs Knowledge." Mayo Clinic Proceedings 85, no. 2 (2010): 112–14. http://dx.doi.org/10.4065/mcp.2009.0777.

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4

Prado, Carla M., M. Cristina Gonzalez, and Steven B. Heymsfield. "Body composition phenotypes and obesity paradox." Current Opinion in Clinical Nutrition and Metabolic Care 18, no. 6 (2015): 535–51. http://dx.doi.org/10.1097/mco.0000000000000216.

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5

Kalantar-Zadeh, Kamyar, Tamara B. Horwich, Antigone Oreopoulos, et al. "Risk factor paradox in wasting diseases." Current Opinion in Clinical Nutrition and Metabolic Care 10, no. 4 (2007): 433–42. http://dx.doi.org/10.1097/mco.0b013e3281a30594.

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6

Guenette, Jordan A., Dennis Jensen, and Denis E. OʼDonnell. "Respiratory function and the obesity paradox." Current Opinion in Clinical Nutrition and Metabolic Care 13, no. 6 (2010): 618–24. http://dx.doi.org/10.1097/mco.0b013e32833e3453.

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7

Lee, Jieun, Kwangil Yim, Dong-Min Kim, Young-Seok Song та Ahwon Lee. "miR-106b-5p, miR-17-5p to predict recurrence and progression in breast DCIS model based on TGFβ paradox." Journal of Clinical Oncology 35, № 15_suppl (2017): e23019-e23019. http://dx.doi.org/10.1200/jco.2017.35.15_suppl.e23019.

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e23019 Background: Ductal carcinoma in situ (DCIS) is a well-known precursor of invasive ductal carcinoma (IDC). Part of patients show disease recurrence as DCIS or IDC after local treatment, but there are no established markers for prediction of recurrence. Methods: Authors analyzed 30 patients diagnosed as pure DCIS, recurrent DCIS, and IDC progressed in DCIS background. miRNA was extracted from archival tissue, and hierarchical clustering of miRNA microarray was performed. We selected highly expressed miR-17-5p and miR-106b-5p as marker for recurrence of DCIS. Two miRNAs were transfected to

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8

Pringle, Ramona. "Periscope's Paradox: The promise and peril of uncensored live video." IEEE Consumer Electronics Magazine 5, no. 4 (2016): 101–2. http://dx.doi.org/10.1109/mce.2016.2590582.

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9

Thornton, Daniel L. "Tests of the Expectations Hypothesis: Resolving the Campbell-Shiller Paradox." Journal of Money, Credit, and Banking 38, no. 2 (2006): 511–42. http://dx.doi.org/10.1353/mcb.2006.0036.

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10

Lavie, Carl J., Sergey Kachur, and Alban De Schutter. "Is there an obesity paradox in coronary heart disease in Asia?" Coronary Artery Disease 28, no. 4 (2017): 273–74. http://dx.doi.org/10.1097/mca.0000000000000471.

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11

Faizi, Shahzad, Wojciech Sałabun, Samee Ullah, Tabasam Rashid, and Jakub Więckowski. "A New Method to Support Decision-Making in an Uncertain Environment Based on Normalized Interval-Valued Triangular Fuzzy Numbers and COMET Technique." Symmetry 12, no. 4 (2020): 516. http://dx.doi.org/10.3390/sym12040516.

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Multi-criteria decision-making (MCDM) plays a vibrant role in decision-making, and the characteristic object method (COMET) acts as a powerful tool for decision-making of complex problems. COMET technique allows using both symmetrical and asymmetrical triangular fuzzy numbers. The COMET technique is immune to the pivotal challenge of rank reversal paradox and is proficient at handling vagueness and hesitancy. Classical COMET is not designed for handling uncertainty data when the expert has a problem with the identification of the membership function. In this paper, symmetrical and asymmetrical

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12

Braiteh, Fadi, and Razelle Kurzrock. "Uncommon tumors and exceptional therapies: paradox or paradigm?" Molecular Cancer Therapeutics 6, no. 4 (2007): 1175–79. http://dx.doi.org/10.1158/1535-7163.mct-06-0674.

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13

Lavie, Carl J., Alban De Schutter, Dharmendrakumar Patel, Surya M. Artham, and Richard V. Milani. "Body Composition and Coronary Heart Disease Mortality—An Obesity or a Lean Paradox?" Mayo Clinic Proceedings 86, no. 9 (2011): 857–64. http://dx.doi.org/10.4065/mcp.2011.0092.

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14

Ferlini, Marco, Giuseppe Musumeci, Niccolò Grieco, et al. "The paradox of clopidogrel use in patients with acute coronary syndromes and diabetes." Coronary Artery Disease 29, no. 4 (2018): 309–15. http://dx.doi.org/10.1097/mca.0000000000000601.

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15

McAuley, Paul A., Peter F. Kokkinos, Ricardo B. Oliveira, Brian T. Emerson, and Jonathan N. Myers. "Obesity Paradox and Cardiorespiratory Fitness in 12,417 Male Veterans Aged 40 to 70 Years." Mayo Clinic Proceedings 85, no. 2 (2010): 115–21. http://dx.doi.org/10.4065/mcp.2009.0562.

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16

Crowe, Nadine Y., Jonathan M. Coquet, Stuart P. Berzins, et al. "Differential antitumor immunity mediated by NKT cell subsets in vivo." Journal of Experimental Medicine 202, no. 9 (2005): 1279–88. http://dx.doi.org/10.1084/jem.20050953.

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We showed previously that NKT cell–deficient TCR Jα18−/− mice are more susceptible to methylcholanthrene (MCA)-induced sarcomas, and that normal tumor surveillance can be restored by adoptive transfer of WT liver-derived NKT cells. Liver-derived NKT cells were used in these studies because of their relative abundance in this organ, and it was assumed that they were representative of NKT cells from other sites. We compared NKT cells from liver, thymus, and spleen for their ability to mediate rejection of the sarcoma cell line (MCA-1) in vivo, and found that this was a specialized function of li

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17

Svyatoslavsky, Alexey V. "M.M. Prishvin and B.A. Pilnyak: To the history of creative relations." Philological Sciences. Scientific Essays of Higher Education, no. 6 (November 2020): 118–27. http://dx.doi.org/10.20339/phs.6-20.118.

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The article considers the history of creative and personal relationships of M. Prishvin and B. Pilnyak from 1922 to the beginning of the 1930s, basing on epistolary and diary entries. In the presence of stable, largely friendly relations between the two writers, their character was complicated by Prishvin’s very critical attitude towards his fellow writer, expressed in a number of sharp assessments of some of Pilnyak’s works. On the other hand, it is noted that Prishvin appreciates the artistic talent of Pilnyak as a master of vivid sketchy images. The discussion on the comparative analysis of

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18

GUNAWARDENA, SHARMINI, MARCELO U. FERREIRA, G. M. G. KAPILANANDA, DYANN F. WIRTH, and NADIRA D. KARUNAWEERA. "The Sri Lankan paradox: high genetic diversity in Plasmodium vivax populations despite decreasing levels of malaria transmission." Parasitology 141, no. 7 (2014): 880–90. http://dx.doi.org/10.1017/s0031182013002278.

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SUMMARYHere we examined whether the recent dramatic decline in malaria transmission in Sri Lanka led to a major bottleneck in the local Plasmodium vivax population, with a substantial decrease in the effective population size. To this end, we typed 14 highly polymorphic microsatellite markers in 185 P. vivax patient isolates collected from 13 districts in Sri Lanka over a period of 5 years (2003–2007). Overall, we found a high degree of polymorphism, with 184 unique haplotypes (12–46 alleles per locus) and average genetic diversity (expected heterozygosity) of 0·8744. Almost 69% (n = 127) isol

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19

Kalantar-Zadeh, Kamyar, Elani Streja, Csaba P. Kovesdy, et al. "The Obesity Paradox and Mortality Associated With Surrogates of Body Size and Muscle Mass in Patients Receiving Hemodialysis." Mayo Clinic Proceedings 85, no. 11 (2010): 991–1001. http://dx.doi.org/10.4065/mcp.2010.0336.

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20

Lavie, Carl J., Richard V. Milani, Hector O. Ventura, and Abel Romero-Corral. "Body Composition and Heart Failure Prevalence and Prognosis: Getting to the Fat of the Matter in the “Obesity Paradox”." Mayo Clinic Proceedings 85, no. 7 (2010): 605–8. http://dx.doi.org/10.4065/mcp.2010.0333.

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21

Gottesfeld, J. M. "DNA sequence-directed nucleosome reconstitution on 5S RNA genes of Xenopus laevis." Molecular and Cellular Biology 7, no. 5 (1987): 1612–22. http://dx.doi.org/10.1128/mcb.7.5.1612.

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Nucleosomes were reconstituted in vitro with several singly end-labeled restriction fragments derived from a cloned somatic-type 5S RNA gene of Xenopus laevis and purified nucleosome core particles from Xenopus cultured cells or chicken erythrocytes. Nucleosome locations were determined by digestion of the reconstitutes with exonuclease III and DNase I and were the same for all fragments investigated, extending from 20 base pairs (bp) within the 5S gene to 80 bp beyond the 3' end of the gene. Both core particles and crude nuclear extracts gave equivalent results, suggesting that no factors oth

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22

Johnson, David G. "The paradox ofE2F1: Oncogene and tumor suppressor gene." Molecular Carcinogenesis 27, no. 3 (2000): 151–57. http://dx.doi.org/10.1002/(sici)1098-2744(200003)27:3<151::aid-mc1>3.0.co;2-c.

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23

Hartsough, Edward J., Curtis H. Kugel, Michael J. Vido, et al. "Response and Resistance to Paradox-Breaking BRAF Inhibitor in Melanomas In Vivo and Ex Vivo." Molecular Cancer Therapeutics 17, no. 1 (2017): 84–95. http://dx.doi.org/10.1158/1535-7163.mct-17-0705.

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24

Goldberg, I. G., H. Sawhney, A. F. Pluta, P. E. Warburton, and W. C. Earnshaw. "Surprising deficiency of CENP-B binding sites in African green monkey alpha-satellite DNA: implications for CENP-B function at centromeres." Molecular and Cellular Biology 16, no. 9 (1996): 5156–68. http://dx.doi.org/10.1128/mcb.16.9.5156.

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Centromeres of mammalian chromosomes are rich in repetitive DNAs that are packaged into specialized nucleoprotein structures called heterochromatin. In humans, the major centromeric repetitive DNA, alpha-satellite DNA, has been extensively sequenced and shown to contain binding sites for CENP-B, an 80-kDa centromeric autoantigen. The present report reveals that African green monkey (AGM) cells, which contain extensive alpha-satellite arrays at centromeres, appear to lack the well-characterized CENP-B binding site (the CENP-B box). We show that AGM cells express a functional CENP-B homolog that

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25

Simon, R., and J. D. Richter. "The degradation sequence of adenovirus E1A consists of the amino-terminal tetrapeptide Met-Arg-His-Ile." Molecular and Cellular Biology 10, no. 11 (1990): 5609–15. http://dx.doi.org/10.1128/mcb.10.11.5609.

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The adenovirus E1A gene product is a potent transcriptional activator and nuclear oncoprotein. Like other regulatory proteins, E1A has a short half-life, in the range of 30 to 120 min. This short half-life, which was measured in cells synthesizing E1A, is not observed in cells injected with E1A protein made in bacteria or in vitro. In these cases, E1A is essentially refractory to degradation. In an attempt to reconcile this apparent paradox, we suggested that E1A was marked for degradation during its synthesis. Furthermore, we showed that a domain in the amino terminus of E1A was required for

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26

Popineau, Lucie, Lucille Morzyglod, Nadège Carré, et al. "Novel Grb14-Mediated Cross Talk between Insulin and p62/Nrf2 Pathways Regulates Liver Lipogenesis and Selective Insulin Resistance." Molecular and Cellular Biology 36, no. 16 (2016): 2168–81. http://dx.doi.org/10.1128/mcb.00170-16.

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A long-standing paradox in the pathophysiology of metabolic diseases is the selective insulin resistance of the liver. It is characterized by a blunted action of insulin to reduce glucose production, contributing to hyperglycemia, whilede novolipogenesis remains insulin sensitive, participating in turn to hepatic steatosis onset. The underlying molecular bases of this conundrum are not yet fully understood. Here, we established a model of selective insulin resistance in mice by silencing an inhibitor of insulin receptor catalytic activity, the growth factor receptor binding protein 14 (Grb14)

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27

Herdratmoko, Mohamad, and DIDI ACHJARI. "DAMPAK PENGUMUMAN PENERAPAN TEKNOLOGI INFORMASI TERHADAP NILAI PERUSAHAAN." Jurnal Riset Akuntansi dan Keuangan 4, no. 1 (2008): 1. http://dx.doi.org/10.21460/jrak.2008.41.139.

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Nowadays, orgonizations tend to invest highty in infprmation technologt However the notion of podrctivity puadox indicates that the investments may not attain intended results. past studies show that the relationship between IT investment and productivity/company perform{mce shows mixed results. This stt$t aims to investigate-market reaction towwds IT implementatibn (mnotn cement in the context of Indonesia.The implementation is expected to provide a signal to tie market since it may have information content of pontential future economic benefits. The current research employs datafrom Inionesi

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28

Jacoby, D. B., J. A. Engle, and H. C. Towle. "Induction of a rapidly responsive hepatic gene product by thyroid hormone requires ongoing protein synthesis." Molecular and Cellular Biology 7, no. 4 (1987): 1352–57. http://dx.doi.org/10.1128/mcb.7.4.1352.

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The regulation of a gene, designated spot 14, which is rapidly induced in rat liver in response to 3,5,3'-triiodo-L-thyronine (T3) was studied as a model for exploring the molecular basis of thyroid hormone action. The time course of induction of the nuclear precursor to spot 14 mRNA after intramuscular injection of T3 displayed a very short lag period of between 10 and 20 min. The rapidity of this effect suggests that the induction in gene expression occurs as a primary response to the hormone-receptor interaction. The protein synthesis inhibitor cycloheximide injected 15 min before T3 comple

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29

al-Alawi, N., D. W. Rose, C. Buckmaster, et al. "Thyrotropin-induced mitogenesis is Ras dependent but appears to bypass the Raf-dependent cytoplasmic kinase cascade." Molecular and Cellular Biology 15, no. 3 (1995): 1162–68. http://dx.doi.org/10.1128/mcb.15.3.1162.

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Cellular growth control requires the coordination and integration of multiple signaling pathways which are likely to be activated concomitantly. Mitogenic signaling initiated by thyrotropin (TSH) in thyroid cells seems to require two distinct signaling pathways, a cyclic AMP (cAMP)-dependent signaling pathway and a Ras-dependent pathway. This is a paradox, since activated cAMP-dependent protein kinase disrupts Ras-dependent signaling induced by growth factors such as epidermal growth factor and platelet-derived growth factor. This inhibition may occur by preventing Raf-1 protein kinase from bi

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30

Ma, Chunqi, Cathy Cummings, and X. Johné Liu. "Biphasic Activation of Aurora-A Kinase during the Meiosis I- Meiosis II Transition in Xenopus Oocytes." Molecular and Cellular Biology 23, no. 5 (2003): 1703–16. http://dx.doi.org/10.1128/mcb.23.5.1703-1716.2003.

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ABSTRACT Xenopus Aurora-A (also known as Eg2) is a member of the Aurora family of mitotic serine/threonine kinases. In Xenopus oocytes, Aurora-A phosphorylates and activates a cytoplasmic mRNA polyadenylation factor (CPEB) and therefore plays a pivotal role in MOS translation. However, hyperphosphorylation and activation of Aurora-A appear to be dependent on maturation-promoting factor (MPF) activation. To resolve this apparent paradox, we generated a constitutively activated Aurora-A by engineering a myristylation signal at its N terminus. Injection of Myr-Aurora-A mRNA induced germinal vesic

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31

Gottesfeld, J. M. "DNA sequence-directed nucleosome reconstitution on 5S RNA genes of Xenopus laevis." Molecular and Cellular Biology 7, no. 5 (1987): 1612–22. http://dx.doi.org/10.1128/mcb.7.5.1612-1622.1987.

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Nucleosomes were reconstituted in vitro with several singly end-labeled restriction fragments derived from a cloned somatic-type 5S RNA gene of Xenopus laevis and purified nucleosome core particles from Xenopus cultured cells or chicken erythrocytes. Nucleosome locations were determined by digestion of the reconstitutes with exonuclease III and DNase I and were the same for all fragments investigated, extending from 20 base pairs (bp) within the 5S gene to 80 bp beyond the 3' end of the gene. Both core particles and crude nuclear extracts gave equivalent results, suggesting that no factors oth

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32

Garrett, J. E., D. S. Knutzon, and D. Carroll. "Composite transposable elements in the Xenopus laevis genome." Molecular and Cellular Biology 9, no. 7 (1989): 3018–27. http://dx.doi.org/10.1128/mcb.9.7.3018.

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Members of two related families of transposable elements, Tx1 and Tx2, were isolated from the genome of Xenopus laevis and characterized. In both families, two versions of the elements were found. The smaller version in each family (Tx1d and Tx2d) consisted largely of two types of 400-base-pair tandem internal repeats. These elements had discrete ends and short inverted terminal repeats characteristic of mobile DNAs that are presumed to move via DNA intermediates, e.g., Drosophila P and maize Ac elements. The longer versions (Tx1c and Tx2c) differed from Tx1d and Tx2d by the presence of a 6.9-

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33

Raught, B., B. Khursheed, A. Kazansky, and J. Rosen. "YY1 represses beta-casein gene expression by preventing the formation of a lactation-associated complex." Molecular and Cellular Biology 14, no. 3 (1994): 1752–63. http://dx.doi.org/10.1128/mcb.14.3.1752.

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Site-specific mutagenesis of the highly conserved milk box (-140 to -110) region suggested that beta-casein expression is regulated by a hormone-mediated relief of repression (M. Schmitt-Ney, W. Doppler, R. K. Ball, and B. Groner, Mol. Cell. Biol. 11:3745-3755, 1991). However, when this sequence was placed upstream of a heterologous thymidine kinase promoter, it activated reporter gene expression. This apparent paradox was resolved when the trans-acting factor YY1, capable of acting as both a positive and negative regulator, was shown to interact with the milk box region, using bacterially exp

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34

Adler, A. J., A. Scheller, and D. M. Robins. "The stringency and magnitude of androgen-specific gene activation are combinatorial functions of receptor and nonreceptor binding site sequences." Molecular and Cellular Biology 13, no. 10 (1993): 6326–35. http://dx.doi.org/10.1128/mcb.13.10.6326.

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The mechanism by which specific hormonal regulation of gene expression is attained in vivo is a paradox in that several of the steroid receptors recognize the same DNA element in vitro. We have characterized a complex enhancer of the mouse sex-limited protein (Slp) gene that is activated exclusively by androgens but not by glucocorticoids in transfection. Potent androgen induction requires both the consensus hormone response element (HRE) and auxiliary elements residing within the 120-bp DNA fragment C' delta 9. Multiple nonreceptor factors are involved in androgen specificity, with respect to

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35

Mograbi, Baharia, Renata Bocciardi, Isabelle Bourget, et al. "The Sensitivity of Activated Cys Ret Mutants to Glial Cell Line-Derived Neurotrophic Factor Is Mandatory To Rescue Neuroectodermic Cells from Apoptosis." Molecular and Cellular Biology 21, no. 20 (2001): 6719–30. http://dx.doi.org/10.1128/mcb.21.20.6719-6730.2001.

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ABSTRACT Hirschsprung's disease (HSCR), a frequent developmental defect of the enteric nervous system is due to loss-of-function mutations of RET, a receptor tyrosine kinase essential for the mediation of glial cell-derived neurotrophic factor (GDNF)-induced cell survival. Instead, gain-of-function Cys mutations (e.g., Cys609, Cys620, and Cys634) of the same gene are responsible for thyroid carcinoma (MEN2A/familial medullary thyroid carcinoma) by causing a covalent Ret dimerization, leading to ligand-independent activation of its tyrosine kinase. In this context, the association of Cys609- or

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36

Wang, Liangjun, Neal Jahren, Marcus L. Vargas, et al. "Alternative ESC and ESC-Like Subunits of a Polycomb Group Histone Methyltransferase Complex Are Differentially Deployed during Drosophila Development." Molecular and Cellular Biology 26, no. 7 (2006): 2637–47. http://dx.doi.org/10.1128/mcb.26.7.2637-2647.2006.

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ABSTRACT The Extra sex combs (ESC) protein is a Polycomb group (PcG) repressor that is a key noncatalytic subunit in the ESC-Enhancer of zeste [E(Z)] histone methyltransferase complex. Survival of esc homozygotes to adulthood based solely on maternal product and peak ESC expression during embryonic stages indicate that ESC is most critical during early development. In contrast, two other PcG repressors in the same complex, E(Z) and Suppressor of zeste-12 [SU(Z)12], are required throughout development for viability and Hox gene repression. Here we describe a novel fly PcG repressor, called ESC-

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37

Simon, R., and J. D. Richter. "The degradation sequence of adenovirus E1A consists of the amino-terminal tetrapeptide Met-Arg-His-Ile." Molecular and Cellular Biology 10, no. 11 (1990): 5609–15. http://dx.doi.org/10.1128/mcb.10.11.5609-5615.1990.

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Abstract:

The adenovirus E1A gene product is a potent transcriptional activator and nuclear oncoprotein. Like other regulatory proteins, E1A has a short half-life, in the range of 30 to 120 min. This short half-life, which was measured in cells synthesizing E1A, is not observed in cells injected with E1A protein made in bacteria or in vitro. In these cases, E1A is essentially refractory to degradation. In an attempt to reconcile this apparent paradox, we suggested that E1A was marked for degradation during its synthesis. Furthermore, we showed that a domain in the amino terminus of E1A was required for

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38

Jacoby, D. B., J. A. Engle, and H. C. Towle. "Induction of a rapidly responsive hepatic gene product by thyroid hormone requires ongoing protein synthesis." Molecular and Cellular Biology 7, no. 4 (1987): 1352–57. http://dx.doi.org/10.1128/mcb.7.4.1352-1357.1987.

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Abstract:

The regulation of a gene, designated spot 14, which is rapidly induced in rat liver in response to 3,5,3'-triiodo-L-thyronine (T3) was studied as a model for exploring the molecular basis of thyroid hormone action. The time course of induction of the nuclear precursor to spot 14 mRNA after intramuscular injection of T3 displayed a very short lag period of between 10 and 20 min. The rapidity of this effect suggests that the induction in gene expression occurs as a primary response to the hormone-receptor interaction. The protein synthesis inhibitor cycloheximide injected 15 min before T3 comple

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39

Garrett, J. E., D. S. Knutzon, and D. Carroll. "Composite transposable elements in the Xenopus laevis genome." Molecular and Cellular Biology 9, no. 7 (1989): 3018–27. http://dx.doi.org/10.1128/mcb.9.7.3018-3027.1989.

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Abstract:

Members of two related families of transposable elements, Tx1 and Tx2, were isolated from the genome of Xenopus laevis and characterized. In both families, two versions of the elements were found. The smaller version in each family (Tx1d and Tx2d) consisted largely of two types of 400-base-pair tandem internal repeats. These elements had discrete ends and short inverted terminal repeats characteristic of mobile DNAs that are presumed to move via DNA intermediates, e.g., Drosophila P and maize Ac elements. The longer versions (Tx1c and Tx2c) differed from Tx1d and Tx2d by the presence of a 6.9-

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40

Raught, B., B. Khursheed, A. Kazansky, and J. Rosen. "YY1 represses beta-casein gene expression by preventing the formation of a lactation-associated complex." Molecular and Cellular Biology 14, no. 3 (1994): 1752–63. http://dx.doi.org/10.1128/mcb.14.3.1752-1763.1994.

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Abstract:

Site-specific mutagenesis of the highly conserved milk box (-140 to -110) region suggested that beta-casein expression is regulated by a hormone-mediated relief of repression (M. Schmitt-Ney, W. Doppler, R. K. Ball, and B. Groner, Mol. Cell. Biol. 11:3745-3755, 1991). However, when this sequence was placed upstream of a heterologous thymidine kinase promoter, it activated reporter gene expression. This apparent paradox was resolved when the trans-acting factor YY1, capable of acting as both a positive and negative regulator, was shown to interact with the milk box region, using bacterially exp

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41

Yeilding, N. M., and W. M. Lee. "Coding elements in exons 2 and 3 target c-myc mRNA downregulation during myogenic differentiation." Molecular and Cellular Biology 17, no. 5 (1997): 2698–707. http://dx.doi.org/10.1128/mcb.17.5.2698.

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Downregulation in expression of the c-myc proto-oncogene is an early molecular event in differentiation of murine C2C12 myoblasts into multinucleated myotubes. During differentiation, levels of c-myc mRNA decrease 3- to 10-fold despite a lack of change in its transcription rate. To identify cis-acting elements that target c-myc mRNA for downregulation during myogenesis, we stably transfected C2C12 cells with mutant myc genes or chimeric genes in which various myc sequences were fused to the human beta-globin gene or to the bacterial chloramphenicol acetyltransferase (CAT) gene. Deletion of cod

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42

Adler, A. J., A. Scheller, and D. M. Robins. "The stringency and magnitude of androgen-specific gene activation are combinatorial functions of receptor and nonreceptor binding site sequences." Molecular and Cellular Biology 13, no. 10 (1993): 6326–35. http://dx.doi.org/10.1128/mcb.13.10.6326-6335.1993.

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The mechanism by which specific hormonal regulation of gene expression is attained in vivo is a paradox in that several of the steroid receptors recognize the same DNA element in vitro. We have characterized a complex enhancer of the mouse sex-limited protein (Slp) gene that is activated exclusively by androgens but not by glucocorticoids in transfection. Potent androgen induction requires both the consensus hormone response element (HRE) and auxiliary elements residing within the 120-bp DNA fragment C' delta 9. Multiple nonreceptor factors are involved in androgen specificity, with respect to

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Biricheva, E. V. "Existential foundations of social responsibility." RUDN Journal of Sociology 20, no. 4 (2020): 763–77. http://dx.doi.org/10.22363/2313-2272-2020-20-4-763-777.

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Issues of vicarious, collective and other types of responsibility become more urgent under the growing global interconnectedness and interdependence. Since most actors are collective ones, we need a theoretical study of the grounds for social responsibility and its essential features as represented in diverse manifestations. The article considers social responsibility in terms of the existential-phenomenological approach developed by M.M. Bakhtin, J.-P. Sartre, M.K. Mamardashvili, H. Arendt, H. Blumer, etc. Social responsibility is a type of responsibility; therefore, the author searches for t

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Greenberg, Charles S., James L. Wells, Caroline D. Vaughn, and Adrian Reuben. "Platelet Count Plays a Major Role in Regulating Fibrin Formation in Cirrhosis: Clinical Study of Whole Blood Coagulation." Blood 118, no. 21 (2011): 2290. http://dx.doi.org/10.1182/blood.v118.21.2290.2290.

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Abstract Abstract 2290 Recent studies document a paradoxical absence of bleeding in the setting of an abnormal PT and aPTT in cirrhosis. A new equilibrium is established between thrombin generation, fibrin formation and fibrinolysis in cirrhosis that confers protection from spontaneous bleeding and may pose a thrombotic risk. The purpose of this study was to evaluate the coagulation paradox in cirrhosis by using whole blood thromboelastometry. Citrate anticoagulated whole blood is added to a cuvette and coagulation is initiated by adding calcium with either a tissue factor (TF)-based reagent (

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El Kholy, Mohamed, Heba Elsedfy, Laurence Perin, et al. "Normal Growth despite Combined Pituitary Hormone Deficiency." Hormone Research in Paediatrics 92, no. 2 (2019): 133–42. http://dx.doi.org/10.1159/000499318.

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Background: The paradox of normal growth despite a lack of growth hormone (GH) is an unexplained phenomenon described in some pathological (sellar, suprasellar, and hypothalamic disorders) and overgrowth syndromes. It has been suggested that the paradoxical growth is due to other GH variants, GH-like moieties, prolactin, insulin, insulin-like growth factors (IGFs), and unidentified serum factors or growth mechanisms. The objective of this study was to determine the mechanism underlying this normal growth without GH. Case Description: We describe here growth, hormonal, and genetic analyses for

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Jones, Steven, Lisa Riste, Christine Barrowclough, et al. "Reducing relapse and suicide in bipolar disorder: practical clinical approaches to identifying risk, reducing harm and engaging service users in planning and delivery of care – the PARADES (Psychoeducation, Anxiety, Relapse, Advance Directive Evaluation and Suicidality) programme." Programme Grants for Applied Research 6, no. 6 (2018): 1–296. http://dx.doi.org/10.3310/pgfar06060.

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BackgroundBipolar disorder (BD) costs £5.2B annually, largely as a result of incomplete recovery after inadequate treatment.ObjectivesA programme of linked studies to reduce relapse and suicide in BD.DesignThere were five workstreams (WSs): a pragmatic randomised controlled trial (RCT) of group psychoeducation (PEd) versus group peer support (PS) in the maintenance of BD (WS1); development and feasibility RCTs of integrated psychological therapy for anxiety in bipolar disorder (AIBD) and integrated for problematic alcohol use in BD (WS2 and WS3); survey and qualitative investigations of suicid

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Bergman, Zinette, and Manfred Max Bergman. "Addendum: Bergman, Z.; Bergman, M.M. A Case Study of the Sustainable Mobility Problem–Solution Paradox: Motility and Access of Metrorail Commuters in the Western Cape. Sustainability 2019, 11, 2842." Sustainability 11, no. 23 (2019): 6694. http://dx.doi.org/10.3390/su11236694.

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"Alcohol, ischemic heart disease, and the French paradox." Coronary Artery Disease 27, no. 1 (2016): 74. http://dx.doi.org/10.1097/mca.0000000000000328.

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Fessel, Jeffrey. "The paradox of opposite directions of gene expressions in MCI and AD suggests possible therapy to prevent progression of MCI to AD." Alzheimer's & Dementia: Translational Research & Clinical Interventions 6, no. 1 (2020). http://dx.doi.org/10.1002/trc2.12003.

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Davis, Ryan J., Jherek Swanger, Bridget T. Hughes, and Bruce E. Clurman. "The PP2A-B56 Phosphatase Opposes Cyclin E Autocatalytic Degradation via Site-Specific Dephosphorylation." Molecular and Cellular Biology 37, no. 8 (2017). http://dx.doi.org/10.1128/mcb.00657-16.

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ABSTRACT Cyclin E, in conjunction with its catalytic partner cyclin-dependent kinase 2 (CDK2), regulates cell cycle progression as cells exit quiescence and enter S-phase. Multiple mechanisms control cyclin E periodicity during the cell cycle, including phosphorylation-dependent cyclin E ubiquitylation by the SCFFbw7 ubiquitin ligase. Serine 384 (S384) is the critical cyclin E phosphorylation site that stimulates Fbw7 binding and cyclin E ubiquitylation and degradation. Because S384 is autophosphorylated by bound CDK2, this presents a paradox as to how cyclin E can evade autocatalytically indu

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