Academic literature on the topic 'MCR - Multicomponent reactions'

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Journal articles on the topic "MCR - Multicomponent reactions"

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Huang, Wenhua, Jinglong Jiang, and Tanmay Mandal. "Ferrite nanoparticles: Catalysis in multicomponent reactions (MCR)." Synthetic Communications 51, no. 16 (2021): 2397–422. http://dx.doi.org/10.1080/00397911.2021.1939883.

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Zarganes-Tzitzikas, Tryfon, and Alexander Dömling. "Modern multicomponent reactions for better drug syntheses." Organic Chemistry Frontiers 1, no. 7 (2014): 834–37. http://dx.doi.org/10.1039/c4qo00088a.

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Ramírez-López, Sandra C., Àngel Rentería-Gómez, Luis E. Cárdenas Galindo, and Rocío Gámez-Montaño. "Synthesis of Tetrakis-Tetrazole via a Repetitive MCR." Chemistry Proceedings 3, no. 1 (2020): 44. http://dx.doi.org/10.3390/ecsoc-24-08395.

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The synthesis of novel and complex molecules of tetrakis-tetrazole was done via a Ugi-azide repetitive reaction from easily accessible starting materials in good yields. The use of orthogonal bifunctional reagents in isocyanide-based multicomponent reactions (IMCR) allowed the synthesis of structurally complex molecules in one pot manner. The molecules herein synthesized could have applications such as use as chelating agents and organocatalysts.
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Reguera, Leslie, Cecilia I. Attorresi, Javier A. Ramírez, and Daniel G. Rivera. "Steroid diversification by multicomponent reactions." Beilstein Journal of Organic Chemistry 15 (June 6, 2019): 1236–56. http://dx.doi.org/10.3762/bjoc.15.121.

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Reports on structural diversification of steroids by means of multicomponent reactions (MCRs) have significantly increased over the last decade. This review covers the most relevant strategies dealing with the use of steroidal substrates in MCRs, including the synthesis of steroidal heterocycles and macrocycles as well as the conjugation of steroids to amino acids, peptides and carbohydrates. We demonstrate that steroids are available with almost all types of MCR reactive functionalities, e.g., carbonyl, carboxylic acid, alkyne, amine, isocyanide, boronic acid, etc., and that steroids are suit
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Pharande, Shrikant G., Manuel A. Rentería-Gómez, and Rocío Gámez-Montaño. "Synthesis of Polyheterocyclic Dimers Containing Restricted and Constrained Peptidomimetics via IMCR-Based Domino/Double CuAAC Click Strategy." Molecules 25, no. 22 (2020): 5246. http://dx.doi.org/10.3390/molecules25225246.

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A novel strategy via the triple process (multicomponent reactions (MCR)-domino)/tandem was developed for the synthesis of restricted and constrained bis-1,2,3-triazole-linked pyrrolo[3,4-b]pyridine peptidomimetics dimers in overall yields of 20–55%. This strategy allows the construction of six heterocycles in two stages of the reaction.
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Sarkar, Satavisha, Deb K. Das, and Abu T. Khan. "Synthesis of fully-substituted pyridines and dihydropyridines in a highly chemoselective manner utilizing a multicomponent reaction (MCR) strategy." RSC Adv. 4, no. 96 (2014): 53752–60. http://dx.doi.org/10.1039/c4ra08237k.

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Zarganes-Tzitzikas, Tryfon, Gonçalo Clemente, Philip Elsinga, and Alexander Dömling. "MCR Scaffolds Get Hotter with 18F-Labeling." Molecules 24, no. 7 (2019): 1327. http://dx.doi.org/10.3390/molecules24071327.

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Imaging techniques, such as positron emission tomography (PET), represent great progress in the clinical development of drugs and diagnostics. However, the efficient and timely synthesis of appropriately labeled compounds is a largely unsolved problem. Numerous small drug-like molecules with high structural diversity can be synthesized via convergent multicomponent reactions (MCRs). The combination of PET labeling with MCR synthesis of biologically active compounds can greatly simplify radioanalytical and imaging-based analysis. In a proof-of-concept study, we optimized robust on-site radiolab
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Raghava Sharma, Ganapavarapu Veera, Bandaru Devi, Karri Someswara Reddy, Mallidi Veeraghava Reddy, Anand Kumar Kondapi, and Cherukuvada Bhaskar. "Montmorillonite K10 catalyzed multi component reactions (MCR): synthesis of novel thiazolidinones as anticancer agents." Heterocyclic Communications 21, no. 4 (2015): 187–90. http://dx.doi.org/10.1515/hc-2015-0035.

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AbstractMontmorillonite K10 is a suitable catalyst in a multicomponent reaction involving an aldehyde, an amine, and thioglycolic acid in N,N-dimethylformamide as solvent at moderate (50°C) to reasonably high (120°C) temperatures to form thiazolidinones. The reaction involves easy workup and purification. Several thiazolidinones were prepared. In particular, campholenic aldehyde obtained from α-pinene was used to synthesize potentially bioactive thiazolidinones. All products were characterized by IR, 1H NMR, and mass spectra. Preliminary anticancer screening tests revealed that two compounds s
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UGI, I., and T. SCHMID. "ChemInform Abstract: Multicomponent Reactions (MCR). Part 8. Synthesis of Aziridine Compounds via Ugi-Reaction." ChemInform 29, no. 2 (2010): no. http://dx.doi.org/10.1002/chin.199802210.

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Koopmanschap, Gijs, Eelco Ruijter, and Romano VA Orru. "Isocyanide-based multicomponent reactions towards cyclic constrained peptidomimetics." Beilstein Journal of Organic Chemistry 10 (March 4, 2014): 544–98. http://dx.doi.org/10.3762/bjoc.10.50.

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In the recent past, the design and synthesis of peptide mimics (peptidomimetics) has received much attention. This because they have shown in many cases enhanced pharmacological properties over their natural peptide analogues. In particular, the incorporation of cyclic constructs into peptides is of high interest as they reduce the flexibility of the peptide enhancing often affinity for a certain receptor. Moreover, these cyclic mimics force the molecule into a well-defined secondary structure. Constraint structural and conformational features are often found in biological active peptides. For
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Dissertations / Theses on the topic "MCR - Multicomponent reactions"

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Saxer, Samantha. "Synthèse de structures macromoléculaires aromatiques et hétérocycliques originales par voies non conventionnelles." Thesis, Lyon, 2018. http://www.theses.fr/2018LYSEI038.

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Le travail réalisé dans cette thèse concerne la synthèse de nouvelles structures macromoléculaires aromatiques et hétérocycliques. La synthèse de ces polymères a été envisagée par des procédés de polycondensation non conventionnels. A la différence des réactions classiques utilisées en polycondensation, des réactions de condensation « multi-composants » faisant intervenir trois ou quatre fonctions réactives ont été considérées. Les réactions de Debus-Radziszewski, Hantzsch, et Chichibabin, permettant la formation directe de structures aromatiques et ou hétérocycliques ont été plus particulière
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Vasconcelos, Stanley Nunes Siqueira. "Síntese de 5-organoteluro-1H-1,2,3-triazóis-1,4-dissubstituídos, funcionalização via reação de acoplamento cruzado de Sonogashira e síntese one-pot de derivados do indol-3-glioxila e indol-3-glioxil-1,2,3-triazóis." Universidade de São Paulo, 2013. http://www.teses.usp.br/teses/disponiveis/9/9138/tde-16012014-141941/.

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No capítulo 1 apresentamos uma síntese eficiente de compostos 5-organoteluro-1H- 1,2,3-triazóis realizada via reação de cicloadição [3+2] entre azidas orgânicas e alquinos substituídos com organotelúrio. Além disso, os 5-organoteluro-1H-1,2,3-triazóis foram funcionalizados na posição 5 do anel triazólico por reação de acoplamento cruzado de Sonogashira. A regioquímica dos produtos de cicloadição foram descritas com base em experimentos de RMN, cálculos teóricos e cristalografia de raio-x. Apresentamos uma proposta mecanística para a cicloadição mediada por cobre, baseada em experimentos de esp
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Fan, Weigang. "Utilisation du HMF en réactions multicomposantes : Accès rapide vers de nouvelles cibles en chimie fine." Thesis, Lyon, 2019. http://www.theses.fr/2019LYSEI022/document.

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L’utilisation de matières premières renouvelables pour la production de produits chimiques est un enjeu majeur de l’industrie chimique. Elle vise à répondre aux contraintes environnementales et économiques de disponibilité des ressources fossiles et de limitation de l’empreinte carbone des produits chimiques. Il existe une famille de molécules fonctionnelles directement issues de la biomasse dénommées « molécules plateforme ». Parmi elles, le 5-hydroxyméthylfurfural (HMF), porteur d’une fonction aldéhyde, un motif furanique et un groupe CH2OH, est particulièrement intéressante. Cependant, sa s
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Book chapters on the topic "MCR - Multicomponent reactions"

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Huang, Yijun, Kareem Khoury, and Alexander Dömling. "The Piperazine Space in Isocyanide-based MCR Chemistry." In Synthesis of Heterocycles via Multicomponent Reactions I. Springer Berlin Heidelberg, 2010. http://dx.doi.org/10.1007/7081_2010_27.

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Banfi, Luca, Andrea Basso, Giuseppe Guanti, and Renata Riva. "Asymmetric Isocyanide-Based MCRs." In Multicomponent Reactions. Wiley-VCH Verlag GmbH & Co. KGaA, 2005. http://dx.doi.org/10.1002/3527605118.ch1.

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Zhang, Wei, and Wen-Bin Yi. "Multicomponent Reactions (MCRs)." In SpringerBriefs in Molecular Science. Springer International Publishing, 2019. http://dx.doi.org/10.1007/978-3-030-22596-4_4.

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Ruijter, Eelco, and Romano V. A. Orru. "Discovery of MCRs." In Multicomponent Reactions in Organic Synthesis. Wiley-VCH Verlag GmbH & Co. KGaA, 2014. http://dx.doi.org/10.1002/9783527678174.ch02.

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Vicente-García, Esther, Nicola Kielland, and Rodolfo Lavilla. "Functionalization of Heterocycles by MCRs." In Multicomponent Reactions in Organic Synthesis. Wiley-VCH Verlag GmbH & Co. KGaA, 2014. http://dx.doi.org/10.1002/9783527678174.ch06.

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Dömling, Alexander, and AlAnod D. AlQahtani. "General Introduction to MCRs: Past, Present, and Future." In Multicomponent Reactions in Organic Synthesis. Wiley-VCH Verlag GmbH & Co. KGaA, 2014. http://dx.doi.org/10.1002/9783527678174.ch01.

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Xing, Dong, and Wenhao Hu. "Diazoacetate and Related Metal-Stabilized Carbene Species in MCRs." In Multicomponent Reactions in Organic Synthesis. Wiley-VCH Verlag GmbH & Co. KGaA, 2014. http://dx.doi.org/10.1002/9783527678174.ch07.

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del Duque, Maria Mar Sanchez, Christophe Allais, Nicolas Isambert, Thierry Constantieux, and Jean Rodriguez. "β-Diketo Building Blocks for MCRs-Based Syntheses of Heterocycles." In Synthesis of Heterocycles via Multicomponent Reactions I. Springer Berlin Heidelberg, 2010. http://dx.doi.org/10.1007/7081_2010_26.

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Vinicius Nora de Souza, Marcus. "Multicomponent Reaction (MCR)." In Exercises in Organic Synthesis Based on Synthetic Drugs. BENTHAM SCIENCE PUBLISHERS, 2020. http://dx.doi.org/10.2174/9789811487569120010009.

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Heravi, Majid, and Vahideh Zadsirjan. "Direct synthesis of heterocycles via MCRs, using a name reaction." In Recent Advances in Applications of Name Reactions in Multicomponent Reactions. Elsevier, 2020. http://dx.doi.org/10.1016/b978-0-12-818584-1.00002-1.

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