Log in

Relevant bibliographies by topics / MCR - Multicomponent reactions / Journal articles

To see the other types of publications on this topic, follow the link: MCR - Multicomponent reactions.

Journal articles on the topic 'MCR - Multicomponent reactions'

Author: Grafiati

Published: 4 June 2021

Last updated: 4 February 2022

Create a spot-on reference in APA, MLA, Chicago, Harvard, and other styles

Select a source type:

Consult the top 47 journal articles for your research on the topic 'MCR - Multicomponent reactions.'

Next to every source in the list of references, there is an 'Add to bibliography' button. Press on it, and we will generate automatically the bibliographic reference to the chosen work in the citation style you need: APA, MLA, Harvard, Chicago, Vancouver, etc.

You can also download the full text of the academic publication as pdf and read online its abstract whenever available in the metadata.

Browse journal articles on a wide variety of disciplines and organise your bibliography correctly.

1

Huang, Wenhua, Jinglong Jiang, and Tanmay Mandal. "Ferrite nanoparticles: Catalysis in multicomponent reactions (MCR)." Synthetic Communications 51, no. 16 (2021): 2397–422. http://dx.doi.org/10.1080/00397911.2021.1939883.

Full text

APA, Harvard, Vancouver, ISO, and other styles

2

Zarganes-Tzitzikas, Tryfon, and Alexander Dömling. "Modern multicomponent reactions for better drug syntheses." Organic Chemistry Frontiers 1, no. 7 (2014): 834–37. http://dx.doi.org/10.1039/c4qo00088a.

Full text

APA, Harvard, Vancouver, ISO, and other styles

3

Ramírez-López, Sandra C., Àngel Rentería-Gómez, Luis E. Cárdenas Galindo, and Rocío Gámez-Montaño. "Synthesis of Tetrakis-Tetrazole via a Repetitive MCR." Chemistry Proceedings 3, no. 1 (2020): 44. http://dx.doi.org/10.3390/ecsoc-24-08395.

Full text

Abstract:

The synthesis of novel and complex molecules of tetrakis-tetrazole was done via a Ugi-azide repetitive reaction from easily accessible starting materials in good yields. The use of orthogonal bifunctional reagents in isocyanide-based multicomponent reactions (IMCR) allowed the synthesis of structurally complex molecules in one pot manner. The molecules herein synthesized could have applications such as use as chelating agents and organocatalysts.

APA, Harvard, Vancouver, ISO, and other styles

4

Reguera, Leslie, Cecilia I. Attorresi, Javier A. Ramírez, and Daniel G. Rivera. "Steroid diversification by multicomponent reactions." Beilstein Journal of Organic Chemistry 15 (June 6, 2019): 1236–56. http://dx.doi.org/10.3762/bjoc.15.121.

Full text

Abstract:

Reports on structural diversification of steroids by means of multicomponent reactions (MCRs) have significantly increased over the last decade. This review covers the most relevant strategies dealing with the use of steroidal substrates in MCRs, including the synthesis of steroidal heterocycles and macrocycles as well as the conjugation of steroids to amino acids, peptides and carbohydrates. We demonstrate that steroids are available with almost all types of MCR reactive functionalities, e.g., carbonyl, carboxylic acid, alkyne, amine, isocyanide, boronic acid, etc., and that steroids are suit

APA, Harvard, Vancouver, ISO, and other styles

5

Pharande, Shrikant G., Manuel A. Rentería-Gómez, and Rocío Gámez-Montaño. "Synthesis of Polyheterocyclic Dimers Containing Restricted and Constrained Peptidomimetics via IMCR-Based Domino/Double CuAAC Click Strategy." Molecules 25, no. 22 (2020): 5246. http://dx.doi.org/10.3390/molecules25225246.

Full text

Abstract:

A novel strategy via the triple process (multicomponent reactions (MCR)-domino)/tandem was developed for the synthesis of restricted and constrained bis-1,2,3-triazole-linked pyrrolo[3,4-b]pyridine peptidomimetics dimers in overall yields of 20–55%. This strategy allows the construction of six heterocycles in two stages of the reaction.

APA, Harvard, Vancouver, ISO, and other styles

6

Sarkar, Satavisha, Deb K. Das, and Abu T. Khan. "Synthesis of fully-substituted pyridines and dihydropyridines in a highly chemoselective manner utilizing a multicomponent reaction (MCR) strategy." RSC Adv. 4, no. 96 (2014): 53752–60. http://dx.doi.org/10.1039/c4ra08237k.

Full text

APA, Harvard, Vancouver, ISO, and other styles

7

Zarganes-Tzitzikas, Tryfon, Gonçalo Clemente, Philip Elsinga, and Alexander Dömling. "MCR Scaffolds Get Hotter with 18F-Labeling." Molecules 24, no. 7 (2019): 1327. http://dx.doi.org/10.3390/molecules24071327.

Full text

Abstract:

Imaging techniques, such as positron emission tomography (PET), represent great progress in the clinical development of drugs and diagnostics. However, the efficient and timely synthesis of appropriately labeled compounds is a largely unsolved problem. Numerous small drug-like molecules with high structural diversity can be synthesized via convergent multicomponent reactions (MCRs). The combination of PET labeling with MCR synthesis of biologically active compounds can greatly simplify radioanalytical and imaging-based analysis. In a proof-of-concept study, we optimized robust on-site radiolab

APA, Harvard, Vancouver, ISO, and other styles

8

Raghava Sharma, Ganapavarapu Veera, Bandaru Devi, Karri Someswara Reddy, Mallidi Veeraghava Reddy, Anand Kumar Kondapi, and Cherukuvada Bhaskar. "Montmorillonite K10 catalyzed multi component reactions (MCR): synthesis of novel thiazolidinones as anticancer agents." Heterocyclic Communications 21, no. 4 (2015): 187–90. http://dx.doi.org/10.1515/hc-2015-0035.

Full text

Abstract:

AbstractMontmorillonite K10 is a suitable catalyst in a multicomponent reaction involving an aldehyde, an amine, and thioglycolic acid in N,N-dimethylformamide as solvent at moderate (50°C) to reasonably high (120°C) temperatures to form thiazolidinones. The reaction involves easy workup and purification. Several thiazolidinones were prepared. In particular, campholenic aldehyde obtained from α-pinene was used to synthesize potentially bioactive thiazolidinones. All products were characterized by IR, 1H NMR, and mass spectra. Preliminary anticancer screening tests revealed that two compounds s

APA, Harvard, Vancouver, ISO, and other styles

9

UGI, I., and T. SCHMID. "ChemInform Abstract: Multicomponent Reactions (MCR). Part 8. Synthesis of Aziridine Compounds via Ugi-Reaction." ChemInform 29, no. 2 (2010): no. http://dx.doi.org/10.1002/chin.199802210.

Full text

APA, Harvard, Vancouver, ISO, and other styles

10

Koopmanschap, Gijs, Eelco Ruijter, and Romano VA Orru. "Isocyanide-based multicomponent reactions towards cyclic constrained peptidomimetics." Beilstein Journal of Organic Chemistry 10 (March 4, 2014): 544–98. http://dx.doi.org/10.3762/bjoc.10.50.

Full text

Abstract:

In the recent past, the design and synthesis of peptide mimics (peptidomimetics) has received much attention. This because they have shown in many cases enhanced pharmacological properties over their natural peptide analogues. In particular, the incorporation of cyclic constructs into peptides is of high interest as they reduce the flexibility of the peptide enhancing often affinity for a certain receptor. Moreover, these cyclic mimics force the molecule into a well-defined secondary structure. Constraint structural and conformational features are often found in biological active peptides. For

APA, Harvard, Vancouver, ISO, and other styles

11

Stalling, Timo, Wolfgang Saak, and Jürgen Martens. "Synthesis of Bicyclic Thiazolidinethiones and Oxazolidinones by Water-Mediated Multicomponent Reactions (MCR) and Ring-Closing Metathesis (RCM)." European Journal of Organic Chemistry 2013, no. 35 (2013): 8022–32. http://dx.doi.org/10.1002/ejoc.201301162.

Full text

APA, Harvard, Vancouver, ISO, and other styles

12

Sharma, Sulochana, Kailash Sharma, Sakshi Pathak, Mahendra Kumar, and Praveen Kumar Sharma. "Synthesis of Medicinally Important Quinazolines and Their Derivatives: A Review." Open Medicinal Chemistry Journal 14, no. 1 (2020): 108–21. http://dx.doi.org/10.2174/1874104502014010108.

Full text

Abstract:

The study of biodynamic heterosystems has proved to be the most attractive and useful for the development of potential drugs with superior properties and works effectively for the treatment of a variety of diseases, including pandemic ones. Out of the thousand biodynamic heterosystems, the quinazoline heterosystem is one that exhibits wide-ranging biological and pharmacological properties. Synthesis of potential medicinal material is comparatively challenging and needed enough time for clinical trials, testing, permissions for concerned authorities, production and supply. Therefore, researcher

APA, Harvard, Vancouver, ISO, and other styles

13

Stalling, Timo, Wolfgang Saak, and Juergen Martens. "ChemInform Abstract: Synthesis of Bicyclic Thiazolidinethiones and Oxazolidinones by Water-Mediated Multicomponent Reactions (MCR) and Ring-Closing Metathesis (RCM)." ChemInform 45, no. 23 (2014): no. http://dx.doi.org/10.1002/chin.201423151.

Full text

APA, Harvard, Vancouver, ISO, and other styles

14

Chattopadhyaya, Jyoti, Alexander Dömling, Klaus Lorenz, Wolfgang Richter, Ivar Ugi, and Birgit Wener. "MCR III1. Multicomponent Reactions and Their Libraries, a New Type of Organic Chemistry of the Isocyanides and Phosphorus Derivatives." Nucleosides and Nucleotides 16, no. 5-6 (1997): 843–48. http://dx.doi.org/10.1080/07328319708002961.

Full text

APA, Harvard, Vancouver, ISO, and other styles

15

Changmai, Bishwajit, Kalyani Rajkumari, Diparjun Das, and Lalthazuala Rokhum. "Microwave-assisted Synthesis of 3,4-Dihydropyrimidin-2(1H)-ones Using Acid-Functionalized Mesoporous Polymer." Current Microwave Chemistry 8, no. 1 (2021): 44–53. http://dx.doi.org/10.2174/2213335608666210329130736.

Full text

Abstract:

Background: In recent years, 3,4-dihydro-pyrimidin-2-(1H)-ones (DHPMs) have attracted significant attention due to their diverse range of biological properties such as antibacterial, antiviral, antitumor, anti-inflammatory, calcium channel blocking activities, etc. Taking into account, in this present work, a polymer-based solid acid catalyst is employed for the microwaveassisted synthesis of DHPMs. Introduction: Multicomponent reactions (MCRs) are attracting utmost attention as they promote the formation of several bonds in a single process with diverse advantages. Biginelli reaction is the t

APA, Harvard, Vancouver, ISO, and other styles

16

Ugi, Ivar Karl. "ChemInform Abstract: MCR. Part 23. The Highly Variable Multidisciplinary Preparative and Theoretical Possibilities of the Ugi Multicomponent Reactions in the Past, Now, and in the Future." ChemInform 30, no. 18 (2010): no. http://dx.doi.org/10.1002/chin.199918278.

Full text

APA, Harvard, Vancouver, ISO, and other styles

17

Sharma, Upendra K., Prabhat Ranjan, Erik V. Van der Eycken, and Shu-Li You. "Sequential and direct multicomponent reaction (MCR)-based dearomatization strategies." Chemical Society Reviews 49, no. 23 (2020): 8721–48. http://dx.doi.org/10.1039/d0cs00128g.

Full text

APA, Harvard, Vancouver, ISO, and other styles

18

Gong, Shan-Shan, Rui Kong, Chunhong Zheng, et al. "Multicomponent reaction-based discovery of pyrimido[2,1-b][1,3]benzothiazole (PBT) as a novel core for full-color-tunable AIEgens." Journal of Materials Chemistry C 9, no. 31 (2021): 10029–36. http://dx.doi.org/10.1039/d1tc02301b.

Full text

APA, Harvard, Vancouver, ISO, and other styles

19

Selvarani, Sivasamy, and Perumal Rajakumar. "Synthesis and antibacterial activity of some novel piperazinophanes with an intraannular ester functionality." New Journal of Chemistry 40, no. 11 (2016): 9494–99. http://dx.doi.org/10.1039/c6nj01956k.

Full text

Abstract:

Ester based 1 : 1 and 2 : 2 oligomeric piperazinophanes were synthesized using a multicomponent reaction (MCR) technique and assessed for their antibacterial activity and further supported by molecular docking studies.

APA, Harvard, Vancouver, ISO, and other styles

20

Serafini, Marta, Alessia Griglio, Sara Viarengo, Silvio Aprile та Tracey Pirali. "An aryne-based three-component access to α-aroylamino amides". Organic & Biomolecular Chemistry 15, № 31 (2017): 6604–12. http://dx.doi.org/10.1039/c7ob01715d.

Full text

Abstract:

A novel multicomponent reaction among arynes, tertiary α-monosubstituted α-isocyanoacetamides and water was discovered to access densely functionalized α-aroylamino amides. The stereoconservative course of the MCR was investigated.

APA, Harvard, Vancouver, ISO, and other styles

21

Sarkar, Satavisha, and Abu T. Khan. "Beyond conventional routes, an unprecedented metal-free chemoselective synthesis of anthranilate esters via a multicomponent reaction (MCR) strategy." Chemical Communications 51, no. 63 (2015): 12673–76. http://dx.doi.org/10.1039/c5cc03369a.

Full text

Abstract:

A hitherto unreported route for the synthesis of anthranilate esters is demonstrated using 2-nitrobenzaldehyde, malonitrile and an alcohol or amine via a metal and oxidant free multicomponent reaction (MCR) strategy.

APA, Harvard, Vancouver, ISO, and other styles

22

Thirunarayanan, Ayyavu, Sivasamy Selvarani, Gracia Francisco, and Perumal Rajakumar. "Efficient Straightforward Synthesis of Amidopiperazinophanes as Versatile Novel Supramolecular Scaffolds." SynOpen 03, no. 04 (2019): 157–63. http://dx.doi.org/10.1055/s-0039-1690333.

Full text

Abstract:

A simple one-pot synthesis of amidopiperazinophanes with a combination of electron-deficient amide groups and electron-rich alkyne and piperazine functionalities has been achieved by using multicomponent reaction (MCR) methodology with the Mannich reaction. Herein, we demonstrate the synthesis of macrocyclic amide structures in good yields. These macrocycles, with electron donor/acceptor sites, are versatile molecules for host–guest and binding.

APA, Harvard, Vancouver, ISO, and other styles

23

Fang, Zheng, Feng Zhang, Bao Hua Zou, et al. "Investigation of Microwave Irradiation in Synthesis of Pyridine-3,5-dicarbonitriles via a Multi-Component Reaction." Advanced Materials Research 749 (August 2013): 293–98. http://dx.doi.org/10.4028/www.scientific.net/amr.749.293.

Full text

Abstract:

Microwave irradiation was employed to synthesise pyridine-3,5-dicarbontriles via a multicomponent reaction. It was discovered that MWI could accelerate the MCR dramatically, either with active aldehydes in ethanol or sterically hindered aldehydes in acetonitrile. MWI showed more dramatically effect upon the MCR using active aldehydes in ethanol, since ethanol was a good MWI solvent. Acetonitrile, which was a poor MWI solvent, was found to be more efficient than ethanol in either MWI system or conventional heating system with sterically hindered aldehydes as building blocks.

APA, Harvard, Vancouver, ISO, and other styles

24

Ciccolini, Cecilia, Giacomo Mari, Gianfranco Favi, Fabio Mantellini, Lucia De Crescentini, and Stefania Santeusanio. "Sequential MCR via Staudinger/Aza-Wittig versus Cycloaddition Reaction to Access Diversely Functionalized 1-Amino-1H-Imidazole-2(3H)-Thiones." Molecules 24, no. 20 (2019): 3785. http://dx.doi.org/10.3390/molecules24203785.

Full text

Abstract:

A multicomponent reaction (MCR) strategy, alternative to the known cycloaddition reaction, towards variously substituted 1-amino-1H-imidazole-2(3H)-thione derivatives has been successfully developed. The novel approach involves α-halohydrazones whose azidation process followed by tandem Staudinger/aza-Wittig reaction with CS2 in a sequential MCR regioselectively leads to the target compounds avoiding the formation of the regioisomer iminothiazoline heterocycle. The approach can be applied to a range of differently substituted α-halohydrazones bearing also electron-withdrawing groups confirming

APA, Harvard, Vancouver, ISO, and other styles

25

Ali, Parvez, Naziyanaz Pathan, and Taibi Ben Hadda. "Benign Methodology and Efficient Catalysis for the One-Pot Multicomponent Synthesis of Dihydropyrimidinones and Thiones: A New Key for Old Lock." Journal of Applied Chemistry 2014 (April 9, 2014): 1–6. http://dx.doi.org/10.1155/2014/835758.

Full text

Abstract:

In the present communication, under the influence of microwaves, cuprous chloride has been demonstrated to be safe, mild, efficient, and inexpensive catalyst for the Biginelli discovered multicomponent reaction (MCR) between aromatic aldehydes, urea/substituted urea, and ethyl acetoacetate to produce structurally diverse dihydropyrimidin-2(1H)-ones (DHPMs) and thiones in an ecofriendly solvent-free protocol. The practical and simple protocol led to excellent yields of the dihydropyrimidin-2(1H)-one derivatives under mild reaction conditions and within short span of reaction times with easy rea

APA, Harvard, Vancouver, ISO, and other styles

26

Sachdeva, Harshita, Rekha Saroj, Sarita Khaturia, and Diksha Dwivedi. "Environ-Economic Synthesis and Characterization of Some New 1,2,4-Triazole Derivatives as Organic Fluorescent Materials and Potent Fungicidal Agents." Organic Chemistry International 2013 (May 12, 2013): 1–19. http://dx.doi.org/10.1155/2013/659107.

Full text

Abstract:

A multicomponent one-pot clean cyclocondensation reaction of 4-chloro-2-nitro aniline/amino acids and aromatic aldehydes/indole-2,3-diones with thiosemicarbazide in water yielding triazole/spiro indole-triazole derivatives in high yields and shorter reaction time and displaying excellent florescent property is reported. The developed MCR may provide a valuable practical tool for the synthesis of new drugs containing the title core fragment. All the newly synthesized compounds have been characterized by IR, 1HNMR, 13CNMR, and fluorescence study and also been screened for antimicrobial activity.

APA, Harvard, Vancouver, ISO, and other styles

27

Ganta, Ravi Kumar, Nagaraju Kerru, Suresh Maddila, and Sreekantha B. Jonnalagadda. "Advances in Pyranopyrazole Scaffolds’ Syntheses Using Sustainable Catalysts—A Review." Molecules 26, no. 11 (2021): 3270. http://dx.doi.org/10.3390/molecules26113270.

Full text

Abstract:

Heterogeneous catalysis plays a crucial role in many chemical processes, including advanced organic preparations and the design and synthesis of new organic moieties. Efficient and sustainable catalysts are vital to ecological and fiscal viability. This is why green multicomponent reaction (MCR) approaches have gained prominence. Owing to a broad range of pharmacological applications, pyranopyrazole syntheses (through the one-pot strategy, employing sustainable heterogeneous catalysts) have received immense attention. This review aimed to emphasise recent developments in synthesising nitrogen-

APA, Harvard, Vancouver, ISO, and other styles

28

Azad, Iqbal, Firoj Hassan, Mohammad `Saquib, et al. "A Critical Review on Advances in the Multicomponent Synthesis of Pyrroles." Oriental Journal of Chemistry 34, no. 4 (2018): 1670–700. http://dx.doi.org/10.13005/ojc/340401.

Full text

Abstract:

Nitrogen containing heterocyclic compounds are biologically significant molecules. This is especially true for pyrrole a five membered nitrogen containing aromatic molecule, which is present as a key structural motif in a large number of drugs and lead molecules. This review aims to provide an overview of the multi-component reaction (MCR) based methodologies used for the synthesis of pyrrole and its derivatives, focusing particularly on eco-friendly methods that avoid the use of hazardous reagents, solvents and catalysts are deemed especially relevant to the disciplines of medicinal chemistry

APA, Harvard, Vancouver, ISO, and other styles

29

Ramírez-López, Sandra C., M. V. Basavanag Unnamatla, and Rocío Gámez-Montaño. "A One-Pot Process for the Synthesis of Alkyne-3-tretrazolyl-tetrazolo [1,5-a] Quinolines." Proceedings 9, no. 1 (2018): 42. http://dx.doi.org/10.3390/ecsoc-22-05798.

Full text

Abstract:

An efficient synthesis of alkyne-3-tetrazolyl-tetrazolo[1,5-a] quinolones via a one-pot isocyanide-based multicomponent reaction (IMCR) process: I-MCR Ugi-azide/SNAr/ring-chain azido tautomerization was performed under eco-friendly conditions. We report the one-pot synthesis of tris-heterocycles containing a tetrazolo[1,5-a] quinoline connected to a 1,5-disubstituted-tetrazole (1,5-DS-T). The synthesis of these compounds is of great interest in synthetic and medicinal chemistry because these heterocycles are considered privileged scaffolds and their preparation and evaluation may lead to the d

APA, Harvard, Vancouver, ISO, and other styles

30

Elsayed, Galal A., Naglaa F. H. Mahmoud, and Sameh A. Rizk. "Solvent-free Synthesis and Antimicrobial Properties of Some Novel Furanone and Spiropyrimidone Derivatives." Current Organic Synthesis 15, no. 3 (2018): 404–13. http://dx.doi.org/10.2174/1570179414666170830124447.

Full text

Abstract:

Background: The regioselective synthesis of spiro-heterocyclic compounds is intriguing since those compounds have unique non-planar structures and great potential for binding to biomolecules because of their inherent rigid chiral structure. A novel class of furanone and spiro-heterocyclic derivatives were synthesized and evaluated for antifungal activities to establish structure-activity relationship (SAR). Results: The synthesis was carried out through one-pot multicomponent reaction (MCR) of 4-aryl-4-oxo-2- butenoic acids, camphor, urea, and hydrogen peroxide in the presence of sodium ethoxi

APA, Harvard, Vancouver, ISO, and other styles

31

Radwan, Mohamed A. A., Fahad M. Alminderej, and Hanem M. Awad. "One-Pot Multicomponent Synthesis and Cytotoxic Evaluation of Novel 7-Substituted-5-(1H-Indol-3-yl)Tetrazolo[1,5-a] Pyrimidine-6-Carbonitrile." Molecules 25, no. 2 (2020): 255. http://dx.doi.org/10.3390/molecules25020255.

Full text

Abstract:

A series of novel 7-substituted-5-(1H-indol-3-yl)tetrazolo[1,5-a]pyrimidine-6-carbonitrile was synthesized via a one-pot, three-multicomponent reaction of appropriate aldehydes, 1H-tetrazole-5-amine and 3-cyanoacetyl indole in catalytic triethylamine. The cytotoxic activity of the new synthesized tetrazolopyrimidine-6-carbonitrile compounds was investigated against HCT-116, MCF-7, MDA-MB-231, A549 human cancer cell lines and one human healthy normal cell line (RPE-1) using the MTT cytotoxicity assay. Compounds 4h, 4b, 4c, 4i and 4a showed potent anticancer activities against human colon cancer

APA, Harvard, Vancouver, ISO, and other styles

32

Wilusz, J., T. Shenk, Y. Takagaki, and J. L. Manley. "A multicomponent complex is required for the AAUAAA-dependent cross-linking of a 64-kilodalton protein to polyadenylation substrates." Molecular and Cellular Biology 10, no. 3 (1990): 1244–48. http://dx.doi.org/10.1128/mcb.10.3.1244.

Full text

Abstract:

A 64-kilodalton (kDa) polypeptide that is cross-linked by UV light specifically to polyadenylation substrate RNAs containing a functional AAUAAA element has been identified previously. Fractionated HeLa nuclear components that can be combined to regenerate efficient and accurate polyadenylation in vitro have now been screened for the presence of the 64-kDa protein. None of the individual components contained an activity which could generate the 64-kDa species upon UV cross-linking in the presence of substrate RNA. It was necessary to mix two components, cleavage stimulation factor and specific

APA, Harvard, Vancouver, ISO, and other styles

33

Hao, Er-Jun, Gong-Xin Li, Zhen-Zhen Lv, et al. "“In situ immobilization” of a multicomponent chiral catalyst (MCC) via non-covalent interactions for heterogeneous asymmetric hydrogenation reactions." Organic Chemistry Frontiers 7, no. 2 (2020): 345–49. http://dx.doi.org/10.1039/c9qo01331h.

Full text

Abstract:

Novel hybrid catalysts that resulted from the anchoring of pyrene-tagged Rh(i) complexes onto graphene materials via π–π stacking interactions show excellent catalytic activity towards the hydrogenation of dehydroamino acid.

APA, Harvard, Vancouver, ISO, and other styles

34

Wilusz, J., T. Shenk, Y. Takagaki, and J. L. Manley. "A multicomponent complex is required for the AAUAAA-dependent cross-linking of a 64-kilodalton protein to polyadenylation substrates." Molecular and Cellular Biology 10, no. 3 (1990): 1244–48. http://dx.doi.org/10.1128/mcb.10.3.1244-1248.1990.

Full text

Abstract:

A 64-kilodalton (kDa) polypeptide that is cross-linked by UV light specifically to polyadenylation substrate RNAs containing a functional AAUAAA element has been identified previously. Fractionated HeLa nuclear components that can be combined to regenerate efficient and accurate polyadenylation in vitro have now been screened for the presence of the 64-kDa protein. None of the individual components contained an activity which could generate the 64-kDa species upon UV cross-linking in the presence of substrate RNA. It was necessary to mix two components, cleavage stimulation factor and specific

APA, Harvard, Vancouver, ISO, and other styles

35

Zarco Juarez, Mónica, Joel Omar Martínez, Olivia Noguez Cordova, et al. "A Green Approach to the Production of Hybrid Diindolylmethane-Phenylboronic Acids via a 3MCR: Promising Antineoplasic Molecules." Journal of Chemistry 2013 (2013): 1–9. http://dx.doi.org/10.1155/2013/531208.

Full text

Abstract:

The current role of the “Green Chemistry Protocol” in multicomponent reactions is first highlighted. Then, the green approach to the production of three novel hybrid diindolylmethanes-phenylboronic acids via a 3MCR is discussed, which features the following: solventless conditions, the use of microwave irradiation to activate the reactions, the absence of catalyst, and an efficient atom economy. The products were achieved with moderate yields (41–61%) within a short time frame (5 min) and appropriately characterized by elemental analysis and spectroscopic methods (NMR:1H,13C,11B; MS: EI, CI, F

APA, Harvard, Vancouver, ISO, and other styles

36

Addoum, Boutaina, Bouchra El khalfi, Mohamed Idiken, et al. "Synthesis, Characterization of Pyrano-[2,3-c]-Pyrazoles Derivatives and Determination of Their Antioxidant Activities." Iranian Journal of Toxicology 15, no. 3 (2021): 175–94. http://dx.doi.org/10.32598/ijt.15.3.798.1.

Full text

Abstract:

Background: Antioxidants are developed to assist the immune system and overcome oxidative stress, the aggression of cellular constituents due to imbalance between reactive oxygen species and the inner antioxidant system. The main objective of this study was to search for new and potent antioxidants to protect humans against diseases associated with oxidative stress. Methods: In this study, three pyrano-[2,3-c]-pyrazole derivatives were synthesized via Multicomponent Reaction (MCR) approach and were characterized, using a melting point, High-Performance Liquid Chromatography (HPLC), and spectro

APA, Harvard, Vancouver, ISO, and other styles

37

Nguyen, Vinh Phu, Hieu Le Trung, Thu Huong Nguyen, DongQuy Hoang, and Thai Hoa Tran. "Synthesis of Biogenic Silver Nanoparticles with Eco-Friendly Processes Using Ganoderma lucidum Extract and Evaluation of Their Theranostic Applications." Journal of Nanomaterials 2021 (August 3, 2021): 1–11. http://dx.doi.org/10.1155/2021/6135920.

Full text

Abstract:

The green synthesis of silver nanoparticles (AgNPs) using plant extract, the cost-effective solution, and the abundance and environmental issue have been gaining much attention to scientists. Ganoderma lucidum (GL) commonly known as Lingzhi in Chinese and Reishi in Japanese, with a proven anticancer benefit, is discovered in the buffer zone of Bach Ma National Park, Nam Dong district, Thua Thien Hue province. In this work, the AgNPs were synthesized in a simple and effective biochemical reduction process using GL which is one of the biological organisms, as a reducing and stable agent. The opt

APA, Harvard, Vancouver, ISO, and other styles

38

Assirey, Eman, Azhaar Alsaggaf, Arshi Naqvi, et al. "Synthesis, Biological Assessment, and Structure Activity Relationship Studies of New Flavanones Embodying Chromene Moieties." Molecules 25, no. 3 (2020): 544. http://dx.doi.org/10.3390/molecules25030544.

Full text

Abstract:

Novel flavanones that incorporate chromene motifs are synthesized via a one-step multicomponent reaction. The structures of the new chromenes are elucidated by using IR, 1H-NMR, 13C-NMR, 1H-1H COSY, HSQC, HMBC, and elemental analysis. The new compounds are screened for their in vitro antimicrobial and cytotoxic activities. The antimicrobial properties are investigated and established against seven human pathogens, employing the agar well diffusion method and the minimum inhibitory concentrations. A majority of the assessed derivatives are found to exhibit significant antimicrobial activities a

APA, Harvard, Vancouver, ISO, and other styles

39

Gad, Emad M., Mohamed S. Nafie, Elsayed H. Eltamany, Magdy S. A. G. Hammad, Assem Barakat, and Ahmed T. A. Boraei. "Discovery of New Apoptosis-Inducing Agents for Breast Cancer Based on Ethyl 2-Amino-4,5,6,7-Tetra Hydrobenzo[b]Thiophene-3-Carboxylate: Synthesis, In Vitro, and In Vivo Activity Evaluation." Molecules 25, no. 11 (2020): 2523. http://dx.doi.org/10.3390/molecules25112523.

Full text

Abstract:

A multicomponent synthesis was empolyed for the synthesis of ethyl 2-amino-4,5,6,7-tetrahydrobenzo[b]thiophene-3-carboxylate 1. An interesting cyclization was obtained when the amino-ester 1 reacted with ethyl isothiocyanate to give the benzo[4,5]thieno[2,3-d][1,3]thiazin-4-one 3. Acylation of the amino-ester 1 with chloroacetyl chloride in DCM and Et3N afforded the acylated ester 4. The amino-ester 1 was cyclized to benzo[4,5]thieno[2,3-d]pyrimidin-4(3H)-one 8, which was reacted with some alkylating agents leading to alkylation at nitrogen 9–13. Hydrazide 14 was utilized as a synthon for the

APA, Harvard, Vancouver, ISO, and other styles

40

Shukla, Paritosh, Ashok Sharma, Leena Fageria, and Rajdeep Chowdhury. "Novel Spiro/non-Spiro Pyranopyrazoles: Eco-Friendly Synthesis, In-vitro Anticancer Activity, DNA Binding, and In-silico Docking Studies." Current Bioactive Compounds 15, no. 2 (2019): 257–67. http://dx.doi.org/10.2174/1573407213666170828165512.

Full text

Abstract:

Background: Cancer being a deadly disease, many reports of new chemical entities are available. Pyranopyrazole (PPZ) compounds have also been disclosed as bioactive molecules but mainly as antimicrobial agents. Based on one previous report and our interest in anticancer drug design, we decided to explore PPZs as anticancer agents. To the best of our knowledge, we found that a comprehensive study, involving synthesis, in-vitro biological activity determination, exploration of the mechanism of inhibition and finally in-silico docking studies, was missing in earlier reports. This is what the pres

APA, Harvard, Vancouver, ISO, and other styles

41

Imamaliyeva, Samira Zakir. "New Thallium Tellurides with Rare Earth Elements." Kondensirovannye sredy i mezhfaznye granitsy = Condensed Matter and Interphases 22, no. 4 (2020): 460–65. http://dx.doi.org/10.17308/kcmf.2020.22/3117.

Full text

Abstract:

Compounds of the Tl4LnTe3 (Ln-Nd, Sm, Tb, Er, Tm) composition were synthesized by the direct interaction of stoichiometric amounts of thallium telluride Tl2Te elementary rare earth elements (REE) and tellurium in evacuated (10-2 Pa) quartz ampoules. The samples obtained were identified by differential thermal and X-ray phase analyses. Based on the data from the heating thermograms, it was shown that these compounds melt with decomposition by peritectic reactions. Analysis of powder diffraction patterns showed that they were completely indexed in a tetragonal lattice of the Tl5Te3 type (space g

APA, Harvard, Vancouver, ISO, and other styles

42

Younus, Hafiza Amna, Mariya Al-Rashida, Abdul Hameed, et al. "Multicomponent reactions (MCR) in medicinal chemistry: a patent review (2010-2020)." Expert Opinion on Therapeutic Patents, December 29, 2020, 1–23. http://dx.doi.org/10.1080/13543776.2021.1858797.

Full text

APA, Harvard, Vancouver, ISO, and other styles

43

Dhananjaya, G., Akula Raghunadh, P. Mahesh Kumar, et al. "Urea as an ammonia surrogate in the Hantzsch’s synthesis of polyhydroquinolines /1,4-dihydropyridines under green reaction conditions." Letters in Organic Chemistry 17 (July 13, 2020). http://dx.doi.org/10.2174/1570178617999200713144504.

Full text

Abstract:

: Synthesis of polyhydroquinolines via Hantzsch’s multicomponent reaction (MCR) involves the use of a hygroscopic and moderately toxic ammonium salt as one of the key reactants. In our effort we have found urea as an effective ammonia surrogate when the MCR was performed in the presence of sulphonic acid functionalized Wang resin (Wang-OSO3H) as a polymeric and recoverable acidic catalyst under green conditions. Urea is relatively less hygroscopic / toxic than the commonly used ammonium salts used in this MCR. The methodology afforded a range of polyhydroquinolines in good yields. Depending on

APA, Harvard, Vancouver, ISO, and other styles

44

Giustiniano, Mariateresa, Camilla Russo, Rolando Cannalire, Paolo Luciano, Francesca Brunelli, and Gian Cesare Tron. "Visible-Light Photocatalytic Ugi/Aza-Wittig Cascade towards 2-Aminomethyl-1,3,4-oxadiazole Derivatives." Synthesis, July 2, 2021. http://dx.doi.org/10.1055/a-1543-3924.

Full text

Abstract:

AbstractA new visible-light photocatalytic multicomponent reaction (MCR) involving N-alkyl-N-methylanilines, N-isocyanoiminotriphenylphosphorane, and carboxylic acids leading to 1,3,4-oxadiazole derivatives is reported. The developed mild reaction conditions enable a broad substrate scope and good functional group tolerance, as further highlighted in the late-stage functionalization of amino acids and drugs. Additionally, a two-step one-pot protocol for the synthesis of non-symmetrical diacylhydrazines is also reported.

APA, Harvard, Vancouver, ISO, and other styles

45

Kerru, Nagaraju, Lalitha Gummidi, Suresh Maddila, and Sreekantha B. Jonnalagadda. "A review of recent advances in the green synthesis of azole- and pyranbased fused heterocycles using MCRs and sustainable catalysts." Current Organic Chemistry 24 (October 20, 2020). http://dx.doi.org/10.2174/1385272824999201020204620.

Full text

Abstract:

Abstract:: Nitrogen, oxygen and sulfur-containing fused heterocycles are of great importance because of their exciting and diverse biological activities. The construction of the carbon-nitrogen and carbon-oxygen through a multicomponent reaction approach by using eco-friendly reusable heterogeneous catalysts are of significant importance as it opens avenues for the introduction of nitrogen and oxygen in organic molecules. Thus, green methodologies have got particular significance in this field; today, green chemistry is considered a tool for introduction sustainable concepts at the fundamental

APA, Harvard, Vancouver, ISO, and other styles

46

El-Saghier, Ahmed M., Mohamed El-Naggar, Abdel Haleem M. Hussein, Abu-Bakr A. El-Adasy, M. Olish, and Aboubakr H. Abdelmonsef. "Eco-Friendly Synthesis, Biological Evaluation, and In Silico Molecular Docking Approach of Some New Quinoline Derivatives as Potential Antioxidant and Antibacterial Agents." Frontiers in Chemistry 9 (June 10, 2021). http://dx.doi.org/10.3389/fchem.2021.679967.

Full text

Abstract:

A new series of quinoline derivatives 5–12 were efficiently synthesized via one-pot multicomponent reaction (MCR) of resorcinol, aromatic aldehydes, β-ketoesters, and aliphatic/aromatic amines under solvent-free conditions. All products were obtained in excellent yields, pure at low-cost processing, and short time. The structures of all compounds were characterized by means of spectral and elemental analyses. In addition, all the synthesized compounds 5–12 were in vitro screened for their antioxidant and antibacterial activity. Moreover, in silico molecular docking studies of the new quinoline

APA, Harvard, Vancouver, ISO, and other styles

47

AL-Mahmoudy, Amany, Alaa Hassan, Tarek Ibrahim, et al. "Novel Benzyloxyphenyl Pyrimidine-5-Carbonitrile Derivatives as Potential Apoptotic Antiproliferative Agents." Anti-Cancer Agents in Medicinal Chemistry 21 (June 12, 2021). http://dx.doi.org/10.2174/1871520621666210612043812.

Full text

Abstract:

Background: Pyrimidine-5-carbonitrile had a broad spectrum of biological activities such as antiviral, antioxidant and anticancer activity. Among similar compounds, monastrol being the most prominent due to cell-permeant inhibitor of mitosis therefore, we investigated the new Pyrimidine-5-carbonitrile as a cytotoxic agent for p53 pathway. Objective: Several new benzyloxyphenyl pyrimidine-5-carbonitrile derivatives were designed, synthesized, characterized, and their cytotoxicity was evaluated. The most active compounds were tested for their activity against p53 as a mechanistic target for anti

APA, Harvard, Vancouver, ISO, and other styles

We offer discounts on all premium plans for authors whose works are included in thematic literature selections. Contact us to get a unique promo code!