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Journal articles on the topic 'MCRs'

Author: Grafiati

Published: 3 June 2025

Last updated: 31 July 2025

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1

Arigi, Awwal Mohammed, Gayoung Park, and Jonghyun Kim. "An Approach to Analyze Diagnosis Errors in Advanced Main Control Room Operations Using the Cause-Based Decision Tree Method." Energies 14, no. 13 (2021): 3832. http://dx.doi.org/10.3390/en14133832.

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Advancements in the nuclear industry have led to the development of fully digitized main control rooms (MCRs)—often termed advanced MCRs—for newly built nuclear power plants (NPPs). Diagnosis is a major part of the cognitive activity in NPP MCRs. Advanced MCRs are expected to improve the working environment and reduce human error, especially during the diagnosis of unexpected scenarios. However, with the introduction of new types of tasks and errors by digital MCRs, a new method to analyze the diagnosis errors in these new types of MCRs is required. Task analysis for operator diagnosis in an a

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Wind, Galina, Arlindo M. da Silva, Peter M. Norris, Steven Platnick, Shana Mattoo, and Robert C. Levy. "Multi-sensor cloud and aerosol retrieval simulator and remote sensing from model parameters – Part 2: Aerosols." Geoscientific Model Development 9, no. 7 (2016): 2377–89. http://dx.doi.org/10.5194/gmd-9-2377-2016.

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Abstract. The Multi-sensor Cloud Retrieval Simulator (MCRS) produces a “simulated radiance” product from any high-resolution general circulation model with interactive aerosol as if a specific sensor such as the Moderate Resolution Imaging Spectroradiometer (MODIS) were viewing a combination of the atmospheric column and land–ocean surface at a specific location. Previously the MCRS code only included contributions from atmosphere and clouds in its radiance calculations and did not incorporate properties of aerosols. In this paper we added a new aerosol properties module to the MCRS code that

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Mao, Mao, Shiyong Li, Qingqi Ren, et al. "Development of a blood-based cancer screening assay with a novel multivariate cancer risk score (MCRS) model by integrating shallow WGS data and plasma protein markers." Journal of Global Oncology 5, suppl (2019): 45. http://dx.doi.org/10.1200/jgo.2019.5.suppl.45.

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45 Background: Despite the increase of our knowledge about carcinogenesis and recent successful development of innovative cancer drugs, cancer mortality has only slightly decreased in the past decades. Cancer early detection is probably the most cost-effective means to reduce cancer mortality as prognosis is much better when cancer is detected and treated at the early stage. Recently studies have demonstrated that blood-based mutation detection approaches may be effective to identify asymptomatic cancer patients from general population. Methods: Here we reported a novel multivariate cancer ris

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T Msweli, Nkosikhona, Hossana Twinomurinzi, and Mymoena Ismail (was Sharif). "The International Case for Micro-Credentials for Life-Wide And Life-Long Learning: A Systematic Literature Review." Interdisciplinary Journal of Information, Knowledge, and Management 17 (2022): 151–90. http://dx.doi.org/10.28945/4954.

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Aim/Purpose: Systematic literature reviews seek to locate all studies that contain material of relevance to a research question and to synthesize the relevant outcomes of those studies. The primary aim of this paper was to synthesize both research and practice reports on micro-credentials (MCRs). Background: There has been an increase in reports and research on the plausibility of MCRs to support dynamic human skills development for an increasingly impatient and rapidly changing digital world. The integration of fast-paced emerging technologies and digitalization necessitate alternative learni

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Ugi, Ivar. "Recent progress in the chemistry of multicomponent reactions." Pure and Applied Chemistry 73, no. 1 (2001): 187–91. http://dx.doi.org/10.1351/pac200173010187.

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The chemistry of multicomponent reactions (MCRs) and isocyanides belongs to three periods: In the century 18591958, isocyanide chemistry was moderately active and was separate from the classical name reactions of the MCRs. In the next period, isocyanides became well available, and MCRs of isocyanides became the most variable way of forming chemical compounds. The year 1993 began a new era of the formation and investigation of the products and the libraries of the Ugi reaction (U-4CR) and higher MCRs of the isocyanides. This chemistry is primarily accomplished in the industrial search and prep

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Neto, Brenno A. D., Rafael O. Rocha, and Marcelo O. Rodrigues. "Catalytic Approaches to Multicomponent Reactions: A Critical Review and Perspectives on the Roles of Catalysis." Molecules 27, no. 1 (2021): 132. http://dx.doi.org/10.3390/molecules27010132.

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In this review, we comprehensively describe catalyzed multicomponent reactions (MCRs) and the multiple roles of catalysis combined with key parameters to perform these transformations. Besides improving yields and shortening reaction times, catalysis is vital to achieving greener protocols and to furthering the MCR field of research. Considering that MCRs typically have two or more possible reaction pathways to explain the transformation, catalysis is essential for selecting a reaction route and avoiding byproduct formation. Key parameters, such as temperature, catalyst amounts and reagent qua

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Zhi, Sanjun, Xiaoming Ma, and Wei Zhang. "Consecutive multicomponent reactions for the synthesis of complex molecules." Organic & Biomolecular Chemistry 17, no. 33 (2019): 7632–50. http://dx.doi.org/10.1039/c9ob00772e.

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Garcia-Cifuentes, Elkin, Isabela Marquez, and Carlos Cano. "Motoric Cognitive Risk Syndrome: Prevalence and Cognitive Performance." Innovation in Aging 5, Supplement_1 (2021): 592. http://dx.doi.org/10.1093/geroni/igab046.2277.

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Abstract Cognitive decline and dementia have a significant impact older adult. Motor Cognitive Risk Syndrome (MCRS) is a pre-dementia stage where slow gait speed and subjective memory complaints are present. MCRS increases the risk of frailty, dementia, disability, falls and overall mortality. We used data from the SABE Colombia study (Health, Well-Being, and Aging) conducted in 2015 in adults aged 60 years and older. After adjusting for confounding variables MCRS was associated with MMSE (OR 0.90, CI 0.82-0.99), pre-frail (OR 9.1, CI 3.26-25.47) and frail (OR 21.38, CI 6.30-72.57). This study

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Rodrigues, A. R., D. Sousa, H. Almeida, and A. M. Gouveia. "Structural determinants regulating cell surface targeting of melanocortin receptors." Journal of Molecular Endocrinology 51, no. 2 (2013): R23—R32. http://dx.doi.org/10.1530/jme-13-0055.

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Melanocortin receptors (MCRs) belong to the G-protein-coupled receptor family of transmembrane proteins. They recognize specific ligands named melanocortins that are mainly produced in the pituitary and hypothalamus. Newly synthesized MCRs at the endoplasmic reticulum are subjected to quality control mechanisms that screen for the correct structure, folding or processing, essential for their proper cell surface expression. Some motifs, located at the N- or C-terminus or even on transmembrane and in loop regions, have been implicated in these biological processes. This article reviews these spe

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Yuan, Xiao-Chen, and Ya-Xiong Tao. "Ligands for Melanocortin Receptors: Beyond Melanocyte-Stimulating Hormones and Adrenocorticotropin." Biomolecules 12, no. 10 (2022): 1407. http://dx.doi.org/10.3390/biom12101407.

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The discovery of melanocortins in 1916 has resulted in more than 100 years of research focused on these peptides. Extensive studies have elucidated well-established functions of melanocortins mediated by cell surface receptors, including MSHR (melanocyte-stimulating hormone receptor) and ACTHR (adrenocorticotropin receptor). Subsequently, three additional melanocortin receptors (MCRs) were identified. Among these five MCRs, MC3R and MC4R are expressed primarily in the central nervous system, and are therefore referred to as the neural MCRs. Since the central melanocortin system plays important

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Gulati, Shivani, Stephy Elza John, and Nagula Shankaraiah. "Microwave-assisted multicomponent reactions in heterocyclic chemistry and mechanistic aspects." Beilstein Journal of Organic Chemistry 17 (April 19, 2021): 819–65. http://dx.doi.org/10.3762/bjoc.17.71.

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Microwave-assisted (MWA) multicomponent reactions (MCRs) have successfully emerged as one of the useful tools in the synthesis of biologically relevant heterocycles. These reactions are strategically employed for the generation of a variety of heterocycles along with multiple point diversifications. Over the last few decades classical MCRs such as Ugi, Biginelli, etc. have witnessed enhanced yield and efficiency with microwave assistance. The highlights of MWA-MCRs are high yields, reduced reaction time, selectivity, atom economy and simpler purification techniques, such an approach can accele

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Orru, Romano V. A. "MCRs and Related Chemistry." QSAR & Combinatorial Science 25, no. 5-6 (2006): 421. http://dx.doi.org/10.1002/qsar.200690018.

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Reguera, Leslie, Cecilia I. Attorresi, Javier A. Ramírez, and Daniel G. Rivera. "Steroid diversification by multicomponent reactions." Beilstein Journal of Organic Chemistry 15 (June 6, 2019): 1236–56. http://dx.doi.org/10.3762/bjoc.15.121.

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Reports on structural diversification of steroids by means of multicomponent reactions (MCRs) have significantly increased over the last decade. This review covers the most relevant strategies dealing with the use of steroidal substrates in MCRs, including the synthesis of steroidal heterocycles and macrocycles as well as the conjugation of steroids to amino acids, peptides and carbohydrates. We demonstrate that steroids are available with almost all types of MCR reactive functionalities, e.g., carbonyl, carboxylic acid, alkyne, amine, isocyanide, boronic acid, etc., and that steroids are suit

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Graziano, Giovanni, Angela Stefanachi, Marialessandra Contino, et al. "Multicomponent Reaction-Assisted Drug Discovery: A Time- and Cost-Effective Green Approach Speeding Up Identification and Optimization of Anticancer Drugs." International Journal of Molecular Sciences 24, no. 7 (2023): 6581. http://dx.doi.org/10.3390/ijms24076581.

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Multicomponent reactions (MCRs) have emerged as a powerful strategy in synthetic organic chemistry due to their widespread applications in drug discovery and development. MCRs are flexible transformations in which three or more substrates react to form structurally complex products with high atomic efficiency. They are being increasingly appreciated as a highly exploratory and evolutionary tool by the medicinal chemistry community, opening the door to more sustainable, cost-effective and rapid synthesis of biologically active molecules. In recent years, MCR-based synthetic strategies have foun

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Tandi, Mukesh, Vaibhav Sharma, Balasubramanian Gopal, and Sandeep Sundriyal. "Multicomponent reactions (MCRs) yielding medicinally relevant rings: a recent update and chemical space analysis of the scaffolds." RSC Advances 15, no. 2 (2025): 1447–89. https://doi.org/10.1039/d4ra06681b.

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We have reviewed the recently reported multicomponent reactions (MCRs) yielding cyclic frameworks in a single pot from simple building blocks under mild conditions. These MCRs may prove to be useful for drug discovery projects.

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Davies, Michael N., Brennon L. O'Callaghan, and Howard C. Towle. "Activation and repression of glucose-stimulated ChREBP requires the concerted action of multiple domains within the MondoA conserved region." American Journal of Physiology-Endocrinology and Metabolism 299, no. 4 (2010): E665—E674. http://dx.doi.org/10.1152/ajpendo.00349.2010.

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Carbohydrate response element-binding protein (ChREBP) is a glucose-dependent transcription factor that stimulates the expression of glycolytic and lipogenic genes in mammals. Glucose regulation of ChREBP has been mapped to its conserved NH2-terminal region of 300 amino acids, designated the MondoA conserved region (MCR). Within the MCR, five domains (MCR1–5) have a particularly high level of conservation and are likely to be important for glucose regulation. We carried out a large-scale deletion and substitution mutational analysis of the MCR domain of ChREBP. This analysis revealed that MCRs

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Lee, Daesung, and Sourav Ghorai. "Aryne-Based Multicomponent Coupling Reactions." Synlett 31, no. 08 (2020): 750–71. http://dx.doi.org/10.1055/s-0039-1690824.

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Multicomponent reactions (MCRs) constitute a powerful synthetic tool to generate a large number of small molecules with high atom economy, which thus can efficiently expand the chemical space with molecular diversity and complexity. Aryne-based MCRs offer versatile possibilities to construct functionalized arenes and benzo-fused heterocycles. Because of their electrophilic nature, arynes couple with a broad range of nucleophiles. Thus, a variety of aryne-based MCRs have been developed, the representative of which are summarized in this account.1 Introduction2 Aryne-Based Multicomponent Reactio

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Park, Jongchul, Yeora Chae, and Seo Hyung Choi. "Analysis of Mortality Change Rate from Temperature in Summer by Age, Occupation, Household Type, and Chronic Diseases in 229 Korean Municipalities from 2007–2016." International Journal of Environmental Research and Public Health 16, no. 9 (2019): 1561. http://dx.doi.org/10.3390/ijerph16091561.

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This study analyzed mortality change rate (MCR: daily change rate of mortality at a given temperature per average summer mortality) for 229 municipalities in Korea considering age, occupation, household type, chronic diseases, and regional temperature distribution. We found that the MCR for heat wave differs depending on socioeconomic factors and the temperature distribution in the region. The MCRs for the elderly (≥65 years of age), outdoor workers, one-person households, and chronic disease patients start to increase at lower temperatures and react more sensitively to temperature than others

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Hackenberg, Amy J. "Mathematical Caring Relations in Action." Journal for Research in Mathematics Education 41, no. 3 (2010): 236–73. http://dx.doi.org/10.5951/jresematheduc.41.3.0236.

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In a small-scale, 8-month teaching experiment, the author aimed to establish and maintain mathematical caring relations (MCRs) (Hackenberg, 2005c) with 4 6th-grade students. From a teacher's perspective, establishing MCRs involves holding the work of orchestrating mathematical learning for students together with an orientation to monitor and respond to energetic fluctuations that may accompany student–teacher interactions. From a student's perspective, participating in an MCR involves some openness to the teacher's interventions in the student's mathematical activity and some willingness to pu

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Wang, Qi, Chun-dong Zhu, Xin Liu, and Rong-fei Ma. "Research on plastic deformation law and forming technology of rotary forging with multi-cone rolls." Advances in Mechanical Engineering 13, no. 4 (2021): 168781402110087. http://dx.doi.org/10.1177/16878140211008759.

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With the development of industrial technology, the application of large diameter-thickness ratio integral discs in various high precision vessels is becoming more and more important. At present, the forming processes of large-diameter disc mainly includes welding and multiple local upsetting, but these processes exhibit large defects and cannot meet the requirements of industry. Therefore, a new metal plastic forming technology, namely rotary forging with multi-cone rolls (MCRs) is proposed to integrally form large diameter and ultra-thin discs. The forming process was simulated by DEFORM-3D f

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Song, Xiaohong, Anyi Zhao, Yan Liu, Jintang Cheng, Sha Chen, and An Liu. "Detection-confirmation-standardization-quantification: a novel method for the quantitative analysis of active components in traditional Chinese medicines." PeerJ Analytical Chemistry 3 (April 29, 2021): e10. http://dx.doi.org/10.7717/peerj-achem.10.

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Background Quantitative analysis of the active ingredients of Traditional Chinese Medicine is a research tendency. The objective of this study was to build a novel method, namely, Detection-confirmation-standardization-quantification (DCSQ), for the quantitative analysis of active components in traditional Chinese medicines, without individual reference standard. Methods Danshen (the dried root of Radix Salvia miltiorrhiza) was used as the matrix. The “extraction” function in high-performance liquid chromatography-mass (HPLC-MS) instrument was used to find the peaks corresponding to cryptotans

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Neto, Brenno A. D., Pedro S. Beck, Jenny E. P. Sorto, and Marcos N. Eberlin. "In Melting Points We Trust: A Review on the Misguiding Characterization of Multicomponent Reactions Adducts and Intermediates." Molecules 27, no. 21 (2022): 7552. http://dx.doi.org/10.3390/molecules27217552.

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We discuss herein the problems associated with using melting points to characterize multicomponent reactions’ (MCRs) products and intermediates. Although surprising, it is not rare to find articles in which these MCRs final adducts (or their intermediates) are characterized solely by comparing melting points with those available from other reports. A brief survey among specialized articles highlights serious and obvious problems with this practice since, for instance, cases are found in which as many as 25 quite contrasting melting points have been attributed to the very same MCR adduct. Indee

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Bosica, Giovanna, and Roderick Abdilla. "Combination of aza-Friedel Crafts MCR with Other MCRs Under Heterogeneous Conditions." Catalysts 15, no. 7 (2025): 657. https://doi.org/10.3390/catal15070657.

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Multicomponent reactions (MCRs) enable the efficient assembly of complex small molecules via multiple bond-forming events in a single step. However, individual MCRs typically yield products with similar core structures, limiting access to larger, more intricate scaffolds. Strategic selection of reactants allows the combination of distinct MCRs, thus facilitating the synthesis of advanced molecular architectures with potential biological significance. Using our previously reported method for performing the aza-Friedel Crafts multicomponent reaction under green heterogeneous conditions, we have

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Dömling, Alexander, Eberhardt Herdtweck, and Stefan Heck. "Cyanamide in isocyanide-based MCRs." Tetrahedron Letters 47, no. 11 (2006): 1745–47. http://dx.doi.org/10.1016/j.tetlet.2006.01.032.

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Hird, Nick. "MCRs: changing the chemists’ mindset." Drug Discovery Today 7, no. 12 (2002): 649. http://dx.doi.org/10.1016/s1359-6446(02)02337-1.

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Dores, Robert M., Liang Liang, Perry Davis, Alexa L. Thomas, and Bogdana Petko. "60 YEARS OF POMC: Melanocortin receptors: evolution of ligand selectivity for melanocortin peptides." Journal of Molecular Endocrinology 56, no. 4 (2016): T119—T133. http://dx.doi.org/10.1530/jme-15-0292.

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The evolution of the melanocortin receptors (MCRs) is linked to the evolution of adrenocorticotrophic hormone (ACTH), the melanocyte-stimulating hormones (MSHs), and their common precursor pro-opiomelanocortin (POMC). The origin of the MCRs and POMC appears to be grounded in the early radiation of the ancestral protochordates. During the genome duplications that have occurred during the evolution of the chordates, the organization plan for POMC was established, and features that have been retained include, the high conservation of the amino acid sequences of α-MSH and ACTH, and the presence of

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Ofori, Edward, Madeline Hooten, Marcus Ortega, Jordan Barajas, and Dara James. "IDENTIFYING MARKERS OF NEURODEGENERATION FOR MOTORIC COGNITIVE RISK SYNDROME." Innovation in Aging 7, Supplement_1 (2023): 688. http://dx.doi.org/10.1093/geroni/igad104.2235.

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Abstract Cognitive disorders, particularly dementia, are a major cause of disability in the elderly population. Gait disturbances, decreased grip strength and memory complaints are early signs of dementia that can occur well before the disease manifests. To better understand the close interactions between the physical and cognitive domains, the concept of Motoric Cognitive Risk Syndrome (MCRS) has been proposed. We had 25 older adults (10 cognitively unimpaired and 15 with MCRS) generate multiple force pulses at 15% of their maximum voluntary contraction with a fixed duration of 2 seconds for

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Nitone, Umesh, Jayaveersinh Mahida, and Seema Agrawal. "ONE-POT MCR REACTION VIA DIFFERENT BASE USED AS CATALYST ANDPEG-400 AS A SOLVENT." RASAYAN Journal of Chemistry 15, no. 04 (2022): 2761–66. http://dx.doi.org/10.31788/rjc.2022.1526815.

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Our motto for this work is green and natural resources use for the development of multicomponent reaction (MCRs) significant approach for the fabrication of polyfunctional molecules in an operatively easy and atom-economic manner, and the finding of novel MCRs appeal to various building blocks. Herein, the latest pyran-based phthalazinone pyrazole hybrids were synthesized by a facile one-pot MCR done by triethylamine, di-isopropyl ethyl amine (DIPEA), tripropylamine (TPA) as a catalyst. Check study led to the recognition of tripropylamine (TPA) with PEG-400 as the potential catalyst and green

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Zhang, Liqin, Jun XIE, Xingying CHEN, Yongsheng Zhan, and Lv Zhou. "Cooperative Game-Based Synergistic Gains Allocation Methods for Wind-Solar-Hydro Hybrid Generation System with Cascade Hydropower." Energies 13, no. 15 (2020): 3890. http://dx.doi.org/10.3390/en13153890.

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In order to encourage hybrid generation of multiple wind/solar/hydro power stakeholders, synergistic gains from hybrid generation should be allocated fairly, efficiently and reasonably to all power stakeholders. This paper explores how cooperative game theory resolves conflicts among multiple wind/solar/hydro power stakeholders. Elaborate allocation processes of the nucleolus, Shapley value and MCRS methods are presented in resolve synergistic gains allocation problems of wind–solar–hydro hybrid generation system with cascade hydropower. By analyzing properties such as existence, uniqueness an

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Stephens, Julie A., James L. Fisher, Robert Wesolowski, and Electra D. Paskett. "Missing Components of Receptor Status Among Women With Invasive Breast Cancer." JAMA Network Open 6, no. 8 (2023): e2330791. http://dx.doi.org/10.1001/jamanetworkopen.2023.30791.

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ImportanceThere are well-known differences in patient outcomes and effective therapeutic options across subtypes of breast cancer (BC), defined by the status of estrogen receptor, progesterone receptor, and erb-B2 receptor tyrosine kinase 2 (ERBB2 [formerly HER2]) expression, making testing for these receptors part of the routine workup for all patients with a diagnosis of invasive BC. Despite its importance, this information is missing in some BC cases.ObjectiveTo identify female patients with BC without record of testing for estrogen receptor, progesterone receptor, or ERBB2 status, defined

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Zhou, Yang, Monica K. Chawla, Jose L. Rios-Monterrosa, et al. "Aged Brains Express Less Melanocortin Receptors, Which Correlates with Age-Related Decline of Cognitive Functions." Molecules 26, no. 20 (2021): 6266. http://dx.doi.org/10.3390/molecules26206266.

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Brain G-protein coupled receptors have been hypothesized to be potential targets for maintaining or restoring cognitive function in normal aged individuals or in patients with neurodegenerative disease. A number of recent reports suggest that activation of melanocortin receptors (MCRs) in the brain can significantly improve cognitive functions of normal rodents and of different rodent models of the Alzheimer’s disease. However, the potential impact of normative aging on the expression of MCRs and their potential roles for modulating cognitive function remains to be elucidated. In the present s

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Ji, Ren-Lei, Shan-Shan Jiang, and Ya-Xiong Tao. "Modulation of Canine Melanocortin-3 and -4 Receptors by Melanocortin-2 Receptor Accessory Protein 1 and 2." Biomolecules 12, no. 11 (2022): 1608. http://dx.doi.org/10.3390/biom12111608.

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The neural melanocortin receptors (MCRs), melanocortin-3 and -4 receptors (MC3R and MC4R), have crucial roles in regulating energy homeostasis. The melanocortin-2 receptor accessory proteins (MRAPs, MRAP1 and MRAP2) have been shown to regulate neural MCRs in a species-specific manner. The potential effects of MRAP1 and MRAP2 on canine neural MCRs have not been investigated before. Herein, we cloned canine (c) MC3R and identified one canine MRAP2 splice variant, MRAP2b, with N-terminal extension of cMRAP2a. Canine MC3R showed higher maximal responses to five agonists than those of human MC3R. W

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Andresen, Trine, Dagmar Lunden, Asbjørn M. Drewes, and Lars Arendt-Nielsen. "Pain sensitivity and experimentally induced sensitisation in red haired females." Scandinavian Journal of Pain 2, no. 1 (2011): 3–6. http://dx.doi.org/10.1016/j.sjpain.2010.08.005.

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AbstractIntroduction and aimPain sensitivity has been linked to the melanocortin-1 receptor (MC1R) gene. A mutation in MC1R can result in pale skin and red hair in humans and may modulate pain responses in general. Human studies have shown that women with non-functional MC1R’s were sensitive to experimental induced cold and heat pain. A study demonstrated that females with red hair required higher dose of anesthesia than females with dark hair to experience analgesia to electrical stimulation. Moreover, women expressing non-functional MC1Rs display greater analgesia from opioid analgesia. If r

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Koszytkowska-Stawińska, Mariola, and Włodzimierz Buchowicz. "Multicomponent reactions in nucleoside chemistry." Beilstein Journal of Organic Chemistry 10 (July 29, 2014): 1706–32. http://dx.doi.org/10.3762/bjoc.10.179.

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This review covers sixty original publications dealing with the application of multicomponent reactions (MCRs) in the synthesis of novel nucleoside analogs. The reported approaches were employed for modifications of the parent nucleoside core or for de novo construction of a nucleoside scaffold from non-nucleoside substrates. The cited references are grouped according to the usually recognized types of the MCRs. Biochemical properties of the novel nucleoside analogs are also presented (if provided by the authors).

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Yan, Yiran, Kailun Li, and Xingping Wang. "Urban Networks in the Yangtze River Delta from the Perspective of Transaction Linkages in Manufacturing Industries: Characteristics, Determinants, and Strategies for Intercity Integration Development." Systems 11, no. 8 (2023): 401. http://dx.doi.org/10.3390/systems11080401.

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In recent years, manufacturing development has received renewed attention from developing and developed countries alike. As mega-city regions (MCRs) are where manufacturing industries converge, the research on urban networks of MCRs under the dominance of manufacturing transaction linkages is currently insufficient. Based on the buyer–supplier linkages of listed manufacturing firms, this paper investigated the characteristics of the urban network in the Yangtze River Delta region (YRDR) in China using the social network analysis method; explored the determinants of nodal centrality and city dy

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Iwasa, Masamitsu, Kazumi Kawabe, and Hreday N. Sapru. "Activation of melanocortin receptors in the intermediolateral cell column of the upper thoracic cord elicits tachycardia in the rat." American Journal of Physiology-Heart and Circulatory Physiology 305, no. 6 (2013): H885—H893. http://dx.doi.org/10.1152/ajpheart.00443.2013.

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Melanocortin receptors (MCRs) are present in the intermediolateral cell column of the spinal cord (IML). We tested the hypothesis that activation of MCRs in the IML elicits cardioacceleratory responses and the source of melanocortins in the IML may be the melanocortin-containing neurons in the hypothalamic arcuate nucleus (ARCN). Experiments were done in urethane-anesthetized, artificially ventilated adult male Wistar rats. Microinjections (50 nl) of α-melanocyte stimulating hormone (α-MSH) (0.4–2 mM) and adrenocorticotropic hormone (ACTH) (0.5–2 mM) into the right IML elicited increases in he

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Pyshniy, Igor M., and Anastasia A. Kozlova. "Analysis of technical tools for diagnostics of motor-car rolling stock under “single-person” train operation." Innotrans, no. 4 (2021): 52–56. http://dx.doi.org/10.20291/2311-164x-2021-4-52-56.

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The article covers the safety challenges of motor car rolling stock (MCRS). The indicators of traffic safety violations on the Sverdlovsk Railway sections for 2020 are analysed, and their comparison with the indicators for 2019 is made. The analysis was carried out for each cause of the violation separately: failures, technological violations and transport accidents. The devices for ensuring traffic safety and the peculiar features of operation of the “Barrier” hardware and software complex installed on the MCRS are reviewed.

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Lee, Kyunghee, Youngjin Heo, Mihwa Han, Mijung Kim, and Hyunseok Choi. "Validity and Reliability of Metacognitive Rating Scale for Nursing Students." Journal of Korean Academy of psychiatric and Mental Health Nursing 30, no. 3 (2021): 269–77. http://dx.doi.org/10.12934/jkpmhn.2021.30.3.269.

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Purpose: The aim of this study was to determine the reliability and validity of the metacognition rating scale (MCRS), which is a revised version of the existing metacognition questionnaire (MCQ) with anger and anxiety added.Methods: A survey was conducted on 591 nursing students at colleges in North and South Gyeongsang Provinces, South Korea. The collected data were processed for the reliability and validity of the MCRS through Cronbach’s ⍺ and confirmatory factor analysis using SPSS 26.0.Results: Cronbach’s ⍺ for the reliability of MCRS was calculated at .88, .86, .77, .74, and .66 for five

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Yin, Feng-Wei, Jiao Huang, Ci-Tong Zhan, et al. "Recycling Fermentation Strategy for Waste Cellular Residues in the Production of Polyunsaturated Fatty Acids." Fermentation 10, no. 2 (2024): 81. http://dx.doi.org/10.3390/fermentation10020081.

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Cellular residues after lipid extraction are the primary waste by-products of microbial polyunsaturated fatty acid production. To mitigate the discharge of cellular residues and reduce the cost of DHA and ARA production, this study examined the utilization of enzymatically hydrolyzed Aurantiochytrium cellular residues (ACRs) and Mortierella alpina cellular residues (MCRs) as nitrogen sources. Results demonstrated that ACRs and MCRs could partially substitute yeast extract (YE) without adverse effects on DHA and ARA fermentation. Moreover, the implementation of a new fermentation medium incorpo

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Jaiswal, Manish, and Ali Abbas. "An Analytical Comparison of Methods in Multi-Criteria Recommendation Systems." International Journal of All Research Education and Scientific Methods 13, no. 05 (2025): 4224–29. https://doi.org/10.56025/ijaresm.2025.1304254224.

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Multi-Criteria Recommender Systems (MCRS) have emerged as a significant advancement over traditional singlecriterion recommendation systems by incorporating multiple dimensions of user preferences. This paper presents a comprehensive comparative analysis of three prominent MCRS approaches: Weighted Sum, TOPSIS, and Fuzzy Logic-Based methods. Using the MovieLens 1M dataset extended with multi-criteria ratings (story, acting, direction), we evaluate these approaches across multiple performance metrics including Mean Absolute Error (MAE), Root Mean Square Error (RMSE), Precision, Recall, and F1-S

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Benzenine, Djamila, Zahira Kibou, Fatima Belhadj, et al. "Efficient Multicomponent Catalyst-Free Synthesis of Substituted 2-Aminopyridines." Chemistry Proceedings 3, no. 1 (2020): 125. http://dx.doi.org/10.3390/ecsoc-24-08381.

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2-aminopyridines scaffolds are an important class of nitrogen heterocyclic compounds with a wide range of biological activities. Multicomponent reactions (MCRs) are useful methods for the construction of nitrogen heterocyclic compounds. In this context, syntheses of 2-aminopyridines derivatives via MCRs have attracted considerable attention in recent years. We present, in this work, a rapid and efficient synthesis of 2-aminopyridine derivatives, via the catalyst-free four-component method. This protocol provides a simple and practical approach to functionalized 2-aminopyridnes from readily ava

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Biswas, Swapan Kumar, and Debasis Das. "One-pot Synthesis of Pyrano[2,3-c]pyrazole Derivatives via Multicomponent Reactions (MCRs) and their Applications in Medicinal Chemistry." Mini-Reviews in Organic Chemistry 19, no. 5 (2022): 552–68. http://dx.doi.org/10.2174/1570193x19666211220141622.

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Background: Many pyrano[2,3-c]pyrazole derivatives display diverse biological activities and some of them are known as anticancer, analgesic, anticonvulsant, antimicrobial, antiinflammatory, and anti-malarial agents. In recent years, easy convergent, multicomponent reactions (MCRs) have been adopted to make highly functionalizedpyrano[2,3-c]pyrazole derivatives of biological interest. The synthesis of 1,4-dihydropyrano[2,3-c]pyrazole (1,4-DHPP, 2), 2,4- dihydropyrano[2,3-c]pyrazole (2,4-DHPP, 3), 4-hydroxypyrano[2,3-c]pyrazole (4-HPP, 4) derivatives, 1,4,4-substitied pyranopyrazole (SPP, 5) we

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Ramli, Ismail, Al Amin Al Amin, and Muhammad Huzairi. "Analisa Kerusakan Cylinder Head pada Diesel Engine QSK 50 MCRS Di Bengkel Sungai Sembilan Nunukan." Syntax Idea 3, no. 7 (2021): 1656. http://dx.doi.org/10.36418/syntax-idea.v3i7.1381.

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Diesel Engine adalah motor bakar pembakaran dalam (Internal Combustion Engine), yang bahan bakarnya disemprotkan ke dalam ruang silinder pada waktu piston berada di titik mati atas (TMA). Penelitian ini bertujuan untuk mengetahui permasalahan yang terjadi pada kepala silinder, khususnya pada mesin QSK 50 MCRS, sehingga perawatan kepala silinder lebih baik, guna mengoptimalkan pengoperasian mesin dalam proses industri. Penelitian ini dilakukan untuk mendapatkan data guna mengetahui penyebab kerusakan kepala silinder pada mesin QSK 50 MCRS. Ada beberapa langkah yang dilakukan termasuk pembersiha

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Shehzad, Muhammad Waleed, Ishtiaq Hussain, Amer Akhtar, and Saadia Fatima. "Self-Efficacy Sources, Reading Self-Efficacy, Metacognitive Reading Strategies and Reading Comprehension Performance: A Correlational Study in Saudi EFL Context." International Journal of Innovation in Teaching and Learning (IJITL) 7, no. 2 (2021): 19–35. http://dx.doi.org/10.35993/ijitl.v7i2.1264.

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Abstract The intended aim of this research was to identify the connection of Self-Efficacy Sources (SES) and Metacognitive Reading Strategies (MCRS) with Reading Comprehension (RC) by deploying reading Self-Efficacy Beliefs (SEB) as a mediating construct. A correlational design was utilized. Proportionate stratified random sampling was deployed to select a sample of 383 Saudi EFL university learners. Questionnaires and a reading comprehension test were employed to gather the data. Structural equation modelling was used to test the relationships. Results indicated that SES were substantia

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Nadhifah, Rizqi Aulia, Yunifa Miftachul Arif, Hani Nurhayati, and Linda Salma Angreani. "Performance of Multi-Criteria Recommender System Using Cosine-Based Similarity for Selecting Halal Tourism." Applied Information System and Management (AISM) 5, no. 2 (2022): 111–16. http://dx.doi.org/10.15408/aism.v5i2.25035.

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Tourism is an activity where people or groups travel voluntarily for relaxation, seeking entertainment, or enjoy cultural diversity both within the city, outside the city, or even abroad. For traveling, information about halal tourism is essential that tourists must know. Tourists can contact a tour guide to find information and recommendations for halal tourism. However, it will cost quite a bit and need for a recommendation system to obtain recommendations and make it easier for tourists to determine which halal tourism to visit. This study aims to obtain the Multi-Criteria Recommender Syste

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Ramli, Ismail, Al Amin Al Amin, and Muhammad Huzairi. "Analisa Kerusakan Cylinder Head pada Diesel Engine QSK 50 MCRS Di Bengkel Sungai Sembilan Nunukan." Syntax Idea 3, no. 7 (2021): 1656–64. http://dx.doi.org/10.46799/syntax-idea.v3i7.1381.

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Diesel Engine adalah motor bakar pembakaran dalam (Internal Combustion Engine), yang bahan bakarnya disemprotkan ke dalam ruang silinder pada waktu piston berada di titik mati atas (TMA). Penelitian ini bertujuan untuk mengetahui permasalahan yang terjadi pada kepala silinder, khususnya pada mesin QSK 50 MCRS, sehingga perawatan kepala silinder lebih baik, guna mengoptimalkan pengoperasian mesin dalam proses industri. Penelitian ini dilakukan untuk mendapatkan data guna mengetahui penyebab kerusakan kepala silinder pada mesin QSK 50 MCRS. Ada beberapa langkah yang dilakukan termasuk pembersiha

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John, Stephy Elza, Shivani Gulati, and Nagula Shankaraiah. "Recent advances in multi-component reactions and their mechanistic insights: a triennium review." Organic Chemistry Frontiers 8, no. 15 (2021): 4237–87. http://dx.doi.org/10.1039/d0qo01480j.

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Platier, Bart, Tim Staps, Peter Koelman, Marc van der Schans, Job Beckers, and Wilbert IJzerman. "Probing Collisional Plasmas with MCRS: Opportunities and Challenges." Applied Sciences 10, no. 12 (2020): 4331. http://dx.doi.org/10.3390/app10124331.

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Since the 1940s, Microwave Cavity Resonance Spectroscopy (MCRS) has been used to investigate a variety of solids, gases, and low-pressure plasmas. Recently, the working terrain of the diagnostic method has been expanded with atmospheric-pressure plasmas. This review discusses the advancements that were required for this transition and implications of studying highly collisional, with respect to the probing frequencies, plasmas. These developments and implications call for a redefinition of the limitations of MCRS, which also impact studies of low-pressure plasmas using the diagnostic method. M

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da Silva, Allan, Deborah dos Santos, Marcio Paixão, and Arlene Corrêa. "Stereoselective Multicomponent Reactions in the Synthesis or Transformations of Epoxides and Aziridines." Molecules 24, no. 3 (2019): 630. http://dx.doi.org/10.3390/molecules24030630.

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Small ring heterocycles, such as epoxides and aziridines, are present in several natural products and are also highly versatile building blocks, frequently involved in the synthesis of numerous bioactive products and pharmaceuticals. Because of the potential for increased efficiency and selectivity, along with the advantages of environmentally benign synthetic procedures, multicomponent reactions (MCRs) have been explored in the synthesis and ring opening of these heterocyclic units. In this review, the recent advances in MCRs involving the synthesis and applications of epoxides and aziridines

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Dai, Qiang, Yan Jiang, Songjin Guo, Jin-Tao Yu та Jiang Cheng. "3-Aza π-allyl palladium derived from imino migration in palladium-carbene: MCRs toward multiple substituted indole skeleton". Chemical Communications 51, № 79 (2015): 14781–84. http://dx.doi.org/10.1039/c5cc05984d.

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