Relevant bibliographies by topics / MDA

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Academic literature on the topic 'MDA'

Author: Grafiati
Published: 4 June 2021
Last updated: 15 June 2025

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Journal articles on the topic "MDA"

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Rahardjani, Kamilah Budhi. "Hubungan antara Malondialdehyde (MDA) dengan Hasil Luaran Sepsis Neonatorum." Sari Pediatri 12, no. 2 (2016): 82. http://dx.doi.org/10.14238/sp12.2.2010.82-7.

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Latar belakang. Sepsis merupakan penyebab morbiditas dan mortalitas terbanyak pada neonatus. Pada sepsis terjadi peningkatan stres oksidatif yang menyebabkan kerusakan jaringan dan hemolisis. Kadar MDA serum merupakan biomarker adanya stress oksidatif.Tujuan. Mengetahui hubungan antara MDA serum dengan hasil luaran sepsis pada neonatus.Metode. Penelitian observasional prospektif dilakukan pada neonatus sepsis yang dirawat di PBRT (Peawatan Bangsal Risiko Tinggi) RSUP Dr. Kariadi Semarang, Oktober 2007 sampai dengan Januari 2008. Diagnosis sepsis berdasar gejala klinik dan pemeriksaan laboratorium. Keluaran sepsis dikelompokkan menjadi dua yaitu perburukan (BR) dan perbaikan (BI). Kadar MDA serum diukur dua kali saat terdiagnosis sepsis (MDA1) dan pada hari ke-5 atau bila terjadi disfungsi organ / meninggal / perburukan (MDA2) dengan menggunakan metode spektofotometri. Analisis statistik menggunakan Uji Wilcoxon Signed – Rank, Mann-Whitney, ROC analysis dan Fisher-exact.Hasil. Subjek penelitian terdiri dari 41 neonatus sepsis, 33 neonatus BI dan 8 neonatus BR. Rerata kadar MDA1 2,97±0,14 dan MDA2 3,05±0,34. Kadar MDA 1 kelompok BI 2,95±0,117, kelompok BR 3,08±0,172 (p=0,03). Kadar MDA2 kelompok BI 2,97±0,182, kelompok BR 3,38±0,591 (p=0,006). Kelompok BI MDA2 meningkat tak bermakna (p=0,9), kelompok BR, MDA2 meningkat bermakna (p=0,01). Kurva ROC luas area bawah kurva MDA1 0,75 (p=0,03), cut-off-point= 2,928 ng/mL. Dijumpai hubungan bermakna antara kategori MDA1 dengan luaran sepsis (p=0,02). Risiko relatif MDA1 ≥2,928 ng/mL untuk hasil luaran sepsis perburukan 7,4 X (95% CI=1,4-37,2).Kesimpulan. Terdapat hubungan antara kadar MDA serum dengan hasil luaran sepsis neonatorum. (
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Sahlström, P., M. Gomes Afonso, V. Joshua, et al. "POS0004 PRO-INFLAMMATORY ANTI-MODIFIED PROTEIN AUTOANTIBODIES DERIVED FROM BONE MARROW, SYNOVIAL, AND LUNG B CELLS PREFERENTIALLY TARGET MALONDIALDEHYDE-ACETALDEHYDE CROSS-LINKED MOLECULAR STRUCTURES." Annals of the Rheumatic Diseases 82, Suppl 1 (2023): 207.1–207. http://dx.doi.org/10.1136/annrheumdis-2023-eular.4681.

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BackgroundAutoantibodies to malondialdehyde (MDA) proteins constitute a subset of anti-modified protein autoantibodies (AMPA) in rheumatoid arthritis (RA), which is not directly overlapping with citrulline reactivity. We have previously shown that IgM anti-MDA is prominent in the natural antibody repertoire at birth and may have homeostatic roles. Yet, IgG anti-MDA is elevated in RA and correlates with DAS28, CRP, IL6 and TNF-α [1]. Moreover, RA-derived anti-MDA monoclonal antibodies induce bone erosion and osteoclastogenesis by modulating cell metabolism [2]. MDA is an oxidation-associated reactive aldehyde that together with acetaldehyde (AA) mediates formation of a range of amino acid adducts including linear MDA-lysine, fluorescent MAA-lysine, and intramolecular cross-linking. MDA/MAA proteins carry multiple adduct-variants, and we here propose that distinct subsets of anti-MDA/MAA antibodies, defined based on the MDA-induced molecular structures recognized, have different pathogenic properties. Moreover, we have investigated the presence of class-switched MDA+ B cells in RA synovium, bone marrow, and bronchoalveolar lavage (BAL).ObjectivesIdentification of RA MDA+ B cells from different compartments and distinct MDA/MAA reactivity patterns.MethodsHuman recombinant mAbs were generated from single-cell sorted B cells from BAL and bone marrow (n=148) and screened for reactivity to MDA and MAA modified antigens. MDA-cyanoborohydride and MDA/MAA-hapten proteins without cross-linking were used for characterization. Serology screening of IgG reactivity to MAA-BSA was performed as previously described [3].ResultsIgG MAA-reactivity is elevated in 49% of ACPA+ RA patients (n=278) compared to 14% of population controls (n=437). We did not detect any significant increase in IgG anti-MAA in ACPA+ RA-risk individuals at baseline,14% had high anti-MAA (n=263), compared to controls. But for risk-individuals that developed arthritis, anti-MAA levels increased at onset of arthritis with 26% displaying elevated levels (n=53). We identified IgG+ MDA+ cells among RA bone marrow plasma cells and BAL B cells from both early RA and ACPA+ RA-risk, which could be compared to three previously identified RA synovial clones. Seven out of eight investigated clones carried somatic hypermutations (SHM). Interestingly, all clones with SHM were found to specifically target MAA cross-linked structures rather than MDA- or MAA-hapten, while the germline-encoded synovial clone F04 bound strongly to linear MDA-lysine in proteins and peptides. Germline converting resulted in reduced MDA/MAA binding, suggesting different origin of the clones compared to F04. All binding was independent of protein backbone. Yet, only a subset of MAA-selective clones with SHM induced robust TNF-α expression in monocyte-derived macrophages and enhanced osteoclastogenesis.ConclusionMDA/MAA positive B cells can be identified in bone marrow and synovium in established RA and in the lungs of early and RA-risk individuals, but serum levels are only increased in conjunction with onset of arthritis and with inflammation. SHM and class-switching suggest affinity maturation and T-cell dependence of these responses. Distinct targeting of different MDA/MAA molecular structures was observed. Future studies will elucidate how MDA recognition patters are related to the anti-MDA inflammatory and bone-modulating properties and disease stages.References[1]Grönwall, C., et al J Autoimmun. 2017 84:29-45[2]Sakuraba, K., et al J Autoimmun. 2022 133:102903[3]Grönwall, C., et al Front Immunol. 202112:627986Acknowledgements:NIL.Disclosure of InterestsNone Declared.
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Sakuraba, K., A. Krishnamurthy, A. Circiumaru, et al. "SAT0017 METABOLIC CHANGES INDUCED BY ANTI-MALONDIALDEHYDE/MALINDIALDEHYDE-ACETALDEHYDE ANTIBODIES PROMOTE OSTEOCLAST DEVELOPMENT." Annals of the Rheumatic Diseases 79, Suppl 1 (2020): 938.2–939. http://dx.doi.org/10.1136/annrheumdis-2020-eular.5013.

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Background:Malondialdehyde (MDA) is a highly reactive compound produced by lipid-peroxidation in situations associated with oxidative stress. MDA can irreversibly modify proteins residues such as lysine, arginine and histidine. In addition, MDA adducts can further react with acetaldehyde to generate malondialdehyde-acetaldehyde (MAA) modifications. Such modifications can give rise to immunogenic neo-epitopes that are recognized by autoantibodies. In fact, anti-MDA/MAA IgG antibodies are significantly increased in the serum of patients with autoimmune diseases, such as rheumatoid arthritis (RA) (1) and systemic lupus erythematosus (2). Recently, we have shown that anti-MDA/MAA IgG antibodies are able to promote osteoclast (OC) differentiationin vitro(1).Objectives:To investigate the molecular mechanisms triggered by anti-MDA/MAA autoantibodies during osteoclastogenesis.Methods:OCs were generated from monocyte-derived macrophages in the presence of the cytokines RANK-L and M-CSF. The development of OCs was monitored by light microscopy following tartrate-resistant acid phosphatase (TRAP) staining and erosion area on synthetic calcium phosphate-coated plates. Three different recombinant human monoclonal anti-MDA/MAA antibodies, cloned from single synovial B cells of RA patients, control antibodies and Fab fragments of the antibodies were added to OC cultures. Glycolysis was inhibited by 2-deoxyglucose, and Fc-gamma receptor I or II by anti-CD64 or anti-CD16 neutralizing antibodies. IL-8 levels were measured by enzyme linked immunosorbent assay. Cellular metabolism was monitored using Seahorse XF Analyzer (extracellular acidification rate and oxygen consumption) and a colorimetric L-Lactate assay.Results:Lactic acid production correlated with the osteoclastogenetic effect of some but not all anti-MDA/MAA antibodies on OCs (R=0.4758, p=0.0252) suggesting an antibody-mediated regulation of glycolysis. Further, extracellular acidification (ECAR) and oxygen consumption (OCR) rate of the developing OCs were increased by the osteoclastogenic anti-MDA/MAA clones (maximum increase of 54% for the ECAR and 78% for the OCR by clone 146+:01G07, and maximum increase of 28% for the ECAR and 39% for the OCR by clone 1103:01H05), but not by the non-osteoclastogenetic anti-MDA/MAA clones or control antibodies. The glycolysis inhibitor 2-deoxyglucose completely abolished the osteoclastogenetic effect of the anti-MDA/MAA clones at drug concentrations that did not influenced baseline OC development. Fab2 fragments of the osteocalstogenetic anti-MDA/MAA clones had no effect on OC development and metabolism. In accordance with this, Fc-gamma receptor I neutralizing antibodies completely abolished the osteocalstogenetic effect of the anti-MDA/MAA clones. The osteoclastogenetic effect of the anti-MDA/MAA antibodies was independent of IL-8 production. In contrast to anti MDA/MAA antibodies, ACPA-mediated osteoclastogenesis was independent of glycolysis and Fc-gamma receptors but dependent on IL-8.Conclusion:Our results describe a novel glycolysis-dependent mechanism by which anti-MDA/MAA antibodies promote osteoclast development that is different from the one previously described for ACPA.References:[1] C. Grönwall et al. Journal of Autoimmunity 84 (2017) 29-45.[2] C. Wang et al. Arthritis and Rheumatism 62 (2010) 2064-2072Disclosure of Interests:Koji Sakuraba: None declared, Akilan Krishnamurthy: None declared, Alexandra Circiumaru: None declared, Meng Sun: None declared, Vijay Joshua: None declared, Marianne Engström: None declared, Xiaowei Zheng: None declared, Cheng Xu: None declared, Khaled Amara: None declared, Vivianne Malmström Grant/research support from: VM has had research grants from Janssen Pharmaceutica, Sergiu-Bogdan Catrina: None declared, Caroline Grönwall: None declared, Bence Réthi: None declared, Anca Catrina: None declared
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Bowo, Prasetyo, Sumarmi Sumarmi, and Sri Hardiatmi. "PENERAPAN MACAM DAN DOSIS PUPUK ORGANIK TERHADAP PERTUMBUHAN DAN HASIL TANAMAN GANDUM (Triticum aestivum L.)." Innofarm:Jurnal Inovasi Pertanian 21, no. 1 (2019): 1. http://dx.doi.org/10.33061/innofarm.v21i1.3311.

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Penelitian tentang “Penerapan macam dan dosis pupuk organik terhadap pertumbuhan dan hasil tanaman Gandum (Triticum aestivum L.)’’ telah dilaksanakan tanggal 08 November 2018 sampai 31 januari 2019 di Green House Fakultas Pertanian Universitas Slamet Riyadi Surakarta. Penelitian ini bertujuan untuk mengetahui dan menentukan pengaruh terbaik terhadap pertumbuhan dan hasil tanaman gandum. Rancangan penelitian yang digunakan adalah rancangan acak lengkap yang terdiri dari 7 perlakuan dan 5 ulangan. Perlakuan : 1) MD0 = tanpa pupk (kontrol), 2) MD1= pupuk kandang dosis 200 g/polybag, 3) MD2 = pupuk kandang dosis 400 g/polybag , 4) MD3 = pupuk guano dosis 200 g/polybag, 5) MD4 = pupuk guano dosis 400 g/polybag, 6) MD5 = pupuk kascing dosis 200 g/polybag, 7) MD6 = pupuk kascing dosis 400 g/polybag. Hasil penelitian menunjukkan bahwa : 1) penerapan macam dan dosis pupuk organik berpengaruh terhadap tinggi tanaman, jumlah daun, dan jumlah anakan, 2) penerapan macam dan dosis pupuk organik tidak berpengaruh terhadaap berat segar brangkasan, berat kering brangkasan, jumlah biji, berat biji, dan berat 100 biji, 3) macam dan dosis pupuk terbaik adalah MD2 (pupuk kandang dosis 400 g/polybag) karena dapat meningkatkan jumlah daun dan jumlah anakan.
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Sakuraba, K., A. Krishnamurthy, A. Circiumaru, et al. "POS0400 METABOLIC CHANGES INDUCED BY ANTI-MALONDIALDEHYDE/MALINDIALDEHYDE-ACETALDEHYDE ANTIBODIES PROMOTE OSTEOCLAST DEVELOPMENT." Annals of the Rheumatic Diseases 80, Suppl 1 (2021): 429. http://dx.doi.org/10.1136/annrheumdis-2021-eular.3678.

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Background:Malondialdehyde (MDA) is a highly reactive compound generated during lipid-peroxidation in conditions associated with oxidative stress. MDA can irreversibly modify proteins (e.g. lysine, arginine and histidine residues). In addition, acetaldehyde can further react with MDA adducts to form malondialdehyde-acetaldehyde (MAA) modification. Such protein modifications can lead to immunogenic neo-epitopes that are recognized by autoantibodies. In fact, anti-MDA/MAA IgG antibodies are significantly increased in the serum of patients with autoimmune diseases, such as rheumatoid arthritis (RA) (1). Interestingly, anti-MDA/MAA antibodies have been shown to promote osteoclast (OC) differentiation in vitro suggesting a potential role for these autoantibodies in bone damage associated with RA (1).Objectives:Little is known about the molecular mechanisms activated by autoantibodies in RA. Here, we elucidate the pathways specifically triggered by anti-MDA/MAA autoantibodies in developing osteoclasts.Methods:Recombinant human monoclonal anti-MDA/MAA antibodies, which were previously cloned from single synovial B cells of RA patients, were added to different OC assays. OCs were generated from monocyte-derived macrophages in the presence of the cytokines RANK-L and M-CSF. OC development was monitored by light microscopy following tartrate-resistant acid phosphatase staining and by erosion assays using calcium phosphate-coated plates. Bone morphometrics were studied in anti-MDA/MAA-injected mice using X-ray microscopy. Cellular metabolism was analyzed by mass spectrometry, Seahorse XF Analyzer and a colorimetric L-Lactate assay.Results:Anti-MDA/MAA antibodies induced a robust OC differentiation in vitro and bone loss in vivo. The anti-MDA/MAA antibodies acted on developing OCs by increasing glycolysis via an Fcγ receptor I-mediated pathway and the upregulation of the transcription factors HIF-1α, Myc and CHREBP. Such regulation of cellular metabolism was exclusively observed in the presence of the osteoclastogenic anti-MDA/MAA clones, whereas other RA-associated autoantibodies (anti-MDA/MAA or anti-citrullinated protein antibodies) had no effect on metabolism. The anti-MDA/MAA treatment induced a shift in the tricarboxylic acid (TCA) cycle activity in developing OCs, leading to the accumulation of citrate and aconitate.Conclusion:We described a novel type of autoantibody-induced pathway in RA, which might contribute to increased OC activation and a consequent bone loss. Anti-MDA/MAA antibodies promoted osteoclast development by increasing glycolysis and by modulating the TCA cycle through a signaling pathway that included Fcγ receptor I and a network of transcription factors acting on glycolysis. A TCA cycle bias towards citrate production suggests that the anti-MDA/MAA antibodies might stimulate OCs via increasing lipid biosynthesis in the cells.References:[1]Grönwall C. et al. J. Autoimmunity 84 (2017): 29-45.Acknowledgements:This Project has received funding from FOREUM, Foundation for Research in Rheumatology, from the European Research Council (ERC) grant agreement CoG 2017 - 7722209_PREVENT RA, the EU/EFPIA Innovative Medicine Initiative grant agreement 777357_RTCure, the Konung Gustaf V:s och Drottning Victorias Frimurarestiftelse and Knut and Alice Wallenberg Foundation.Disclosure of Interests:Koji Sakuraba: None declared, Akilan Krishnamurthy: None declared, Alexandra Circiumaru: None declared, Vijay Joshua: None declared, Heidi Wähämaa: None declared, Marianne Engström: None declared, Meng Sun: None declared, Xiaowei Zheng: None declared, Cheng Xu: None declared, Khaled Amara: None declared, Vivianne Malmström Grant/research support from: collaboration with Pfizer, unrelated to the abstract, Sergiu-Bogdan Catrina: None declared, Caroline Grönwall: None declared, Bence Réthi: None declared, Anca Catrina Grant/research support from: collaboration with BMS and Pfizer, unrelated to the present abstract
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Lu, Na, Junji Li, Changwei Bi, et al. "ChimeraMiner: An Improved Chimeric Read Detection Pipeline and Its Application in Single Cell Sequencing." International Journal of Molecular Sciences 20, no. 8 (2019): 1953. http://dx.doi.org/10.3390/ijms20081953.

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As the most widely-used single cell whole genome amplification (WGA) approach, multiple displacement amplification (MDA) has a superior performance, due to the high-fidelity and processivity of phi29 DNA polymerase. However, chimeric reads, generated in MDA, cause severe disruption in many single-cell studies. Herein, we constructed ChimeraMiner, an improved chimeric read detection pipeline for analyzing the sequencing data of MDA and classified the chimeric sequences. Two datasets (MDA1 and MDA2) were used for evaluating and comparing the efficiency of ChimeraMiner and previous pipeline. Under the same hardware condition, ChimeraMiner spent only 43.4% (43.8% for MDA1 and 43.0% for MDA2) processing time. Respectively, 24.4 million (6.31%) read pairs out of 773 million reads, and 17.5 million (6.62%) read pairs out of 528 million reads were accurately classified as chimeras by ChimeraMiner. In addition to finding 83.60% (17,639,371) chimeras, which were detected by previous pipelines, ChimeraMiner screened 6,736,168 novel chimeras, most of which were missed by the previous pipeline. Applying in single-cell datasets, all three types of chimera were discovered in each dataset, which introduced plenty of false positives in structural variation (SV) detection. The identification and filtration of chimeras by ChimeraMiner removed most of the false positive SVs (83.8%). ChimeraMiner revealed improved efficiency in discovering chimeric reads, and is promising to be widely used in single-cell sequencing.
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Oida, Yasuhisa, Began Gopalan, Ryo Miyahara, et al. "Sulindac enhances adenoviral vector expressing mda-7/IL-24–mediated apoptosis in human lung cancer." Molecular Cancer Therapeutics 4, no. 2 (2005): 291–304. http://dx.doi.org/10.1158/1535-7163.291.4.2.

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Abstract Several studies have shown antitumor activities of the melanoma differentiation–associated gene 7 (mda-7) and the nonsteroidal anti-inflammatory drug sulindac when used as a monotherapies against a wide variety of human cancers. However, the combined effects of mda-7 and sulindac have not previously been tested. Therefore, we tested the antitumor activity of an adenoviral vector expressing mda-7 (Ad-mda7) in combination with sulindac against non–small cell lung cancer cells in vitro and in vivo. When treated with Ad-mda7 in combination with sulindac, human lung cancer cells (A549 and H1299) underwent growth suppression resulting in apoptosis. The growth inhibition induced by Ad-mda7 in combination with sulindac was significantly greater than that observed with Ad-mda7 or sulindac alone. Furthermore, the degree of growth inhibition induced using this combination was dose-dependent for sulindac. Treatment with Ad-mda7 in combination with sulindac had no growth inhibitory effects on human normal lung (CCD-16) fibroblasts. We then investigated the mechanism by which sulindac enhances Ad-mda7-mediated apoptosis. Sulindac increased expression of ectopic MDA-7 protein in tumor cells, thereby increasing the expression of downstream effectors RNA-dependent protein kinase, p38MAPK, caspase-9, and caspase-3 and enhancing apoptosis of non–small cell lung cancer cells. Pulse-chase experiments showed that the increased expression of MDA-7 protein in sulindac-treated cells was due to increased half-life of the MDA-7 protein. Finally, treatment of human lung tumor xenografts in nude mice with Ad-mda7 plus sulindac significantly suppressed growth (P = 0.001) compared with Ad-mda7 or sulindac alone. Our results show for the first time that combined treatment with Ad-mda7 plus sulindac enhances growth inhibition and apoptosis of human lung cancer cells. The increased antitumor activity observed with the combination treatment is a result of increased half-life of MDA-7 protein. Regulation of protein turnover is a heretofore-unrecognized mechanism of this nonsteroidal anti-inflammatory drug.
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Lee, Seung-Han, and Jae-Pyo Park. "A Case Study of Software Development Quality Improvement by Agile Methodology and MDA/MDD Technology." Journal of the Korea Academia-Industrial cooperation Society 16, no. 4 (2015): 2744–48. http://dx.doi.org/10.5762/kais.2015.16.4.2744.

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Hayati, Alfiah, Soesanto Mangkoewidjojo, Aucky Hinting, and Sukarti Moeljopawiro. "HUBUNGAN KADAR MDA SPERMA DENGAN INTEGRITAS MEMBRAN SPERMATOZOA TIKUS (Rattus norvegicus) SETELAH PEMAPARAN 2–METHOXYETHANOL." Berkala Penelitian Hayati 11, no. 2 (2006): 151–54. http://dx.doi.org/10.23869/bphjbr.11.2.20069.

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In the body, 2-methoxyethanol compound may be converted to MAA. MAA is a strong oxidant and may cause oxidation stress in spermatozoa. Oxidation stress is a disturbance on phosphorilation that increases ROS concentration, and it produces lipid peroxide in spermatozoa membrane resulted in high MDA concentration. One of indicator of spermatozoa membrane disturbances is a lack of spermatozoa membrane integrity. The main purpose of this research was to determine the relationship between MDA concentration in sperm and membrane integrity of spermatozoa in rats. The animal of treated groups (n = 40) were divide into 8 groups of 5 each. The rats were given subcutaneous injection with 0,2 ml of 200 mg/kg/day for 1 day (P1), 3 days (P2), 6 days/week (P3), and 12 days/two weeks (P4), respectively the control group was injected with physiological saline of the same volume. The concentration of MDA was measured by spectrophotometer and observing membrane integrity used HOS method to watch the spermatozoa response on hypoosmotic condition. The results of the research indicated that 2-ME caused the increasing in sperm MDA concentration and the decrease of spermatozoa membrane integrity. There was negative correlations between MDA concentration and spermatozoa membrane integrity.
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Ellerhorst, Julie A., Victor G. Prieto, Suhendan Ekmekcioglu, et al. "Loss of MDA-7 Expression With Progression of Melanoma." Journal of Clinical Oncology 20, no. 4 (2002): 1069–74. http://dx.doi.org/10.1200/jco.2002.20.4.1069.

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PURPOSE: Ectopic transfer of the melanoma differentiation-associated gene-7 (mda-7) has been shown in vitro to suppress growth and induce apoptosis in a variety of human tumor cell lines; similar effects are not elicited in normal cells. Thus, the mda-7 gene seems to function as a novel tumor suppressor, and there is interest in the potential of mda-7 gene transfer as cancer therapy. The objective of this study was to determine if MDA-7 protein is lost during primary melanoma progression from superficial to invasive stages and from localized to metastatic tumor. As a secondary objective, we analyzed MDA-7 protein expression in primary melanomas for correlation with predictors of outcome and with survival. MATERIALS AND METHODS: MDA-7 protein expression was evaluated by immunohistochemistry in 41 primary melanomas and 41 metastases, including 24 paired samples. Each sample was scored for the percentage of positive cells and the overall intensity of immunolabeling. RESULTS: Significant decreases in MDA-7 immunostaining, reflected in both number and intensity scores, were observed when comparing the intraepidermal and superficially invasive portions with the deeply invasive portions of primary tumors. Significant differences were also observed when comparing primary tumors to paired metastases. CONCLUSION: Downregulation of MDA-7 expression in primary melanomas facilitates progression to invasive and metastatic stages. These data support the development of Ad-mda7 as gene therapy for advanced melanoma.
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Dissertations / Theses on the topic "MDA"

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Chaves, Rafael Alves. "Aspectos e MDA." Florianópolis, SC, 2004. http://repositorio.ufsc.br/xmlui/handle/123456789/87201.

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Dissertação (mestrado) - Universidade Federal de Santa Catarina, Centro Tecnológico. Programa de Pós-Graduação em Ciência da Computação.<br>Made available in DSpace on 2012-10-21T16:17:57Z (GMT). No. of bitstreams: 1 235612.pdf: 591706 bytes, checksum: 504520bc0ea1832a0e9fadc7b3c69fed (MD5)<br>As principais contribuições deste trabalho consistem em analisar o potencial do uso conjunto das abordagens MDA e orientação a aspectos, e propor extensões à UML para comportar a criação de modelos executáveis usando o paradigma de aspectos.
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BARBOSA, Paulo Eduardo e. Silva. "MDA-VERITAS: uma arquitetura MDA estendida para transformações de sistemas concorrentes preservadoras de semântica." Universidade Federal de Campina Grande, 2011. http://dspace.sti.ufcg.edu.br:8080/jspui/handle/riufcg/1764.

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Submitted by Johnny Rodrigues (johnnyrodrigues@ufcg.edu.br) on 2018-09-20T18:52:30Z No. of bitstreams: 1 PAULO EDUARDO E SILVA BARBOSA - TESE PPGCC 2011..pdf: 8460190 bytes, checksum: 711c8b40aaed80c81ec520880038d9b8 (MD5)<br>Made available in DSpace on 2018-09-20T18:52:30Z (GMT). No. of bitstreams: 1 PAULO EDUARDO E SILVA BARBOSA - TESE PPGCC 2011..pdf: 8460190 bytes, checksum: 711c8b40aaed80c81ec520880038d9b8 (MD5) Previous issue date: 2011-09-08<br>MDA é uma tendência de desenvolvimento de software que visa alterar o foco e os esforços dos modelos de desenvolvimento atuais. O método de implementação deixa de ser apenas a produção e código, e passa a também envolver modelos, metamodelos e transformações. Atualmente, essa abordagem tem sido diversificada com a inclusão de novos paradigmas que vão bem além do uso exclusivo dos padrões da OMG, como proposto originalmente. Contudo, a arquitetura MDA ainda sofre com a falta de formalização de alguns de seus artefatos e processos, levando a vários tipos de questionamentos. Um exemplo pertinente de questionamento se dá sobre o alto grau de ambigüidade dos modelos e transformações, originando problemas de baixa confiabilidade. Uma das conseqüências disso é o fato de que atualmente não existe uma maneira de garantir que transformações MDA sejam preservadoras de semântica, e nem que seus modelos envolvidos nas transformações sejam formais o suficiente para se permitir o uso de técnicas deverificação de equivalência, gerando críticas sobre a eficácia dessa abordagem. Esta tese de doutorado propõe lidar com esse problema, incorporando abordagens consolidadas de métodos formais na arquitetura MDA, tendo como contexto específico o desenvolvimento de software para sistemas embarcados com características de concorrência. Propomos extensões para parte da arquitetura MDA para que se possa construir modelos semânticos que representem aspectos estáticos e dinâmicos, ambos essenciais na semântica dos modelos envolvidos nas transformações e nos mecanismos de verificação de equivalência desses modelos. Com isso,obtemos a verificação de equivalência em transformações envolvendo modelos de sistemas concorrentes. Como avaliação do trabalho, provas de conceito, estudos de caso e avaliação experimental seguindo a abordagem GQM, envolvendo parcerias na academia e na indústria através de sistemas reais, foram implementados e avaliados. Verificamos equivalência entre modelos ao nível de transformações PIM-para-PIM, PSM-para-PSM e PIMpara-PSM como modelos de sistemas concorrentes descritos em redes de Petri e algumas de suas extensões.<br>MDA is a software development trend that aims to shift the focus and efforts of the current development methodologies. The implementation method changes from only code production to the usage of models, metamodels and transformations. Currently, this approach has been diversified with the inclusion of new paradigms that go beyond the only use of the MDA standards, as originally proposed. However, the MDA architecture still suffers from the lack of formalization of its artifacts and processes, leading to several sorts of questions. An important example of question is about the high ambiguity levels of models and transformations, originating problems of low reliability. One of the main consequences of this problem is the fact that still there is no way to ensure that MDA transformations are semantics preserving and neither the involved models are formal enough to allow the use of equivalence verification techniques, criticizing the effectiveness of this approach. This thesis proposes to deal with this problem by incorporating well consolidated formal methods techniques in the MDA architecture, having as specific context the software development for embedded systems with concurrent features. We propose extensions to part of the MDA architecture in order to construct semantic models to represent static and dynamic aspects, both essentials in the semantics of the involved models in the transformations and in the verification mechanisms of these models. With this, we achieve the verification of equivalence in transformations with models of concurrent systems. Asevaluationofthework,conceptualproofs, case studies and an experimental evaluation following the GQM approach, involving partners in the academy and industry, were implmented and evaluated. We verify models equivalence at the level of PIM-to-PIM, PSM-to-PSM and PIM-to-PSM transformations with models of concurrent systems described and inPetri nets and some of its extensions.
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Lorio, Ryan. "Feasibility of Determining Radioactivity in Lungs Using a Thyroid Uptake Counter." Thesis, Available online, Georgia Institute of Technology, 2005, 2005. http://etd.gatech.edu/theses/available/etd-08102005-173443/.

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Thesis (M. S.)--Mechanical Engineering, Georgia Institute of Technology, 2006.<br>Ansari, Armin, Committee Member ; Hertel, Nolan, Committee Chair ; Wang, Chris, Committee Member. Includes bibliographical references.
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Soares, Inali Wisniewski. "PM-MDA: um método para o desenvolvimento de modelos de plataforma no contexto da MDA." Universidade Tecnológica Federal do Paraná, 2012. http://repositorio.utfpr.edu.br/jspui/handle/1/716.

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Esta tese propõe um método denominado PM-MDA para o desenvolvimento de Modelos de Plataforma (Platform Model - PM) no contexto da abordagem Model Driven Architecture (MDA). O método PM-MDA tem como foco o desenvolvimento de projetos de Software embarcado baseados em Sistemas Operacionais em Tempo Real (Real-Time Operating System - RTOS). Adicionalmente, este estudo define um perfil UML 2.0 para modelagem da aplicação e plataforma de software embarcado denominado Profile for modeling Application and Platform of Embedded Software (PROAPES) que é usado no método PM-MDA. Tal perfil define um conjunto de estereótipos para descrever genericamente Modelos de Plataforma e Modelos Independentes de Plataforma (Platform Independent Model - PIM). Além disso, são definidas extensões desse perfil, tal como o perfil PROAPESX que permite a modelagem de PMs para versões do RTOS X Real-Time Kernel e hardware associados. Além disso, o perfil PROAPES possibilita vincular um PIM a um PM, permitindo que esses modelos sejam inseridos como atributos de entrada em uma Transformação de Modelos. No contexto da MDA, esse perfil constitui-se em um metamodelo de plataforma (um metamodelo de uma família de plataformas similares) para a construção de modelos de plataforma. Desse modo, um PM é usado como parte fundamental para o desenvolvimento de software embarcado na abordagem MDA, fornecendo meios de obter independência de plataforma. Em abordagens atuais de MDA, as transformações de modelos empregam implicitamente os modelos de plataforma. Como os interesses referentes à plataforma não são separados dos interesses referentes às transformações de modelos, para cada plataforma requerida deve existir uma ou mais transformações de modelos correspondentes que são configuradas especificamente para aquela plataforma. O resultado são processos de transformações de modelos difíceis de serem automatizados. No domínio de sistemas embarcados, o uso de MDA é ainda mais importante devido à heterogeneidade de plataformas e à complexidade destes sistemas. O método PM-MDA, que faz uso do perfil PROAPES, visa sistematizar o processo de criação e disponibilização de modelos de plataforma separados do processo de transformação de modelos, possibilitando a geração de processos de transformações de modelos eficientes e adaptáveis.<br>This thesis proposes a method called PM-MDA for the development of Platform Models in the context of Model Driven Architecture (MDA). The PM-MDA method focuses on the development of embedded software projects based on Real-Time Operating Systems (RTOS). Additionally, this study defines a UML 2.0 Profile for Modeling Application and Platform of Embedded Software (PROAPES), which is used in the PM-MDA method. Such profile defines a set of stereotypes to generically describe Platform Models (PMs) and Platform Independent Models (PIMs). Further, extensions are defined in this profile, e.g. the PROAPESX profile, allowing the modeling of PMs into versions of the X RTOS Real-Time Kernel and associated hardware. In its turn, the PROAPES profile enables the link of a PIM to a PM, allowing these models to be entered as input attributes in a Model Transformation. In the context of MDA, this profile is a platform metamodel for building PMs, i.e., a metamodel of a family of similar platforms. In this way, a PM is used as a fundamental part in the development of embedded software in the MDA approach by providing means of obtaining platform independence. In current MDA approaches, model transformations implicitly employ PMs. As the concerns regarding the platform are not separated from the concerns related to model transformations, for each required platform there must be one or more corresponding model transformations that are configured specifically for that platform. This results in model transformation processes that are expensive and difficult to be automated. In some application domains such as embedded systems, the use of MDA is more motivating because of the heterogeneity of platforms and the complexity of these systems. The PM-MDA method, which makes use of the PROAPES profile, aims to systematize the process of creating and providing platform models separated from the model transformation process, enabling the generation of efficient and adaptable model transformations.
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Heicke, Matthias. "Automated sequential composition of deltas and related optimization operations : An additional research to metamodel independent difference representation." Thesis, Mälardalen University, Mälardalen University, Mälardalen University, 2009. http://urn.kb.se/resolve?urn=urn:nbn:se:mdh:diva-7478.

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<p>Model-Driven Engineering (MDE) leverages models to first-class status by shifting the focus of software development from coding to modeling. This thesis extends Antonio Cicchettis paper Difference Representation and Conflict Management in Model-Driven Engineering, adding concrete research corresponding to sequential composition.Differences between models can be displayed as deltas in a metamodel independent way. Working with these deltas, a need for sequential composites appears. This means, that several sequently deltas are marged together to a new delta. Since this delta contains a lot of unnecessary information, it needs to be optimized regarding to the minimal paradigm which is mentioned in the corresponding paper. This paper supplies the reader with a broad overview of the basic concepts, the difference representation and application including the metamodel independent approach, and finally a narrow examination of the research topic, including constraints, examples and implementation details.</p>
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Cormick, Justin. "Isotope ratio analysis of 3,4-methylenedioxyamphetamine (MDA) and 3,4-methylenedioxymethylamphetamine (MDMA) synthesised from helional." Thesis, Griffith University, 2022. http://hdl.handle.net/10072/415810.

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Illicit drug profiling describes the applications of chemical or physical drug profiles to areas such as law enforcement and legislation. Stable isotope analysis by stable isotope ratio mass spectrometry (IRMS) has become a useful tool for illicit drug profiling purposes. The following research was focused on the illicit drug profiling of 3,4-methylenedioxyamphetamine (MDA) and 3,4-methylenedioxmethylamphetamine (MDMA) by IRMS. Following an extensive literature review, it was surmised that the illicit drug profiling of MDMA (and a lesser extent MDA) by IRMS was complicated. Previous research suggested that stable isotopic compositions of MDA/MDMA may not be characteristic of the synthetic history. Traditional precursors for these drugs have similar, plant-based origins and similar isotopic compositions. The changes to isotopic compositions during the synthesis of MDA/MDMA made it difficult to establish links back to specific precursors. The control of traditional precursors has seen illicit manufacturing utilise alternative compounds. Helional has emerged as a novel precursor for MDA and MDMA, and although recently legislated against in Queensland, Australia, remains largely uncontrolled in many other jurisdictions. The aim of this research was to investigate further the analysis of MDA and MDMA by IRMS, with particular focus on the alternative precursor helional. This was performed with the following individual aims: 1. To investigate the δ2H, δ13C and δ18O composition variation in traditional and alternative MDA/MDMA precursors available in Queensland, Australia including the novel precursor helional. 2. To investigate the δ13C and δ15N composition variation in nitrogen sources used for the synthesis of MDA and MDMA. 3. To investigate the synthesis of MDA and MDMA from helional, and characterisation to determine what, if any isotopic changes occur during each stage of synthesis. 4. To investigate the HCl salt precipitation of MDA and MDMA and to determine what, if any isotopic changes occur during this process. A survey of traditional and alternative precursors and pre-precursors, from which MDA/MDMA can be produced, found a greater variation in stable isotope ratios than previously reported. Of particular interest were samples found with δ13C values more negative than traditional precursors, including helional (between –32.47 and –32.21‰) and 3,4-methylenedioxyphenyl-2-propanone (MDP2P) prepared from the methyl-glycidate masking group (methyl-3-[3,4- (methylenedioxy)phenyl]-2-methyl-glycidate (MMDMG)) (–31.39‰). A survey of ATS nitrogen sources by IRMS was also conducted. Much greater variation was found in the δ15N compositions for the alternative nitrogen sources nitromethane (–37.21 to – 0.10‰) and hydroxylamine (–97.87 to +2.19‰). Hydroxylamine is utilised in the production of MDA from helional, and can itself be produced from nitromethane. Changes to stable isotope ratios from precursors and nitrogen sources to MDA and MDMA, and during the HCl salt precipitation, were next investigated. One pathway from helional to MDP2P was investigated via an enamine intermediate, and from MDP2P to MDMA by reductive amination. From helional to MDA two methods were investigated, both proceeding through an amide intermediate. Minimal change was observed in δ13C composition from helional to MDA and MDMA, however, isotopic changes occurred in δ2H, δ15N and δ18O compositions. During the HCl salt precipitation minimal change was seen in δ13C and δ18O composition. When multiple precipitations of the HCl salt were collected, changes occurred to δ2H and δ15N values. If high yields of MDA/MDMA were collected as the HCl salt and homogenised, this isotopic fractionation is expected to be reduced. These results have implications to the illicit drug profiling of MDA and MDMA by IRMS. With minimal changes to δ13C composition, this element may provide limited information about the synthetic history of a sample, especially when MDA or MDMA was prepared from alternative precursors with more negative δ13C values. Changes observed in δ2H, δ15N and δ18O values suggest that these elements may be more useful in characterising batch-to-batch variations between MDA or MDMA samples.<br>Thesis (PhD Doctorate)<br>Doctor of Philosophy (PhD)<br>School of Environment and Sc<br>Science, Environment, Engineering and Technology<br>Full Text
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Gall, Dariusz, and Michał Molenda. "EDOC to EJB transformations within MDA." Thesis, Blekinge Tekniska Högskola, Avdelningen för programvarusystem, 2005. http://urn.kb.se/resolve?urn=urn:nbn:se:bth-4159.

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The Model Driven Architecture is a proposition of the framework of software development process where main accent is put on system models, i.e. platform independent and platform dependent models, and transformations between them. Applying the MDA is related with preparation of these two types of assets. In the thesis, the EDOC and the EJB platform are considered as an examples of platform-independent and platform dependent models. In order to complete this picture, additionally transformations between these two models are required. The authors focus in the thesis on transformations. In particular, the authors present the transformation specification description, and specify set of transformations between the EDOC and EJB models. The transformations are narrowed to the subset of structural aspects of the EDOC models.
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Škultinas, Tomas. "MDA panaudojimo programinės įrangos kūrimui tyrimas." Master's thesis, Lithuanian Academic Libraries Network (LABT), 2005. http://vddb.library.lt/obj/LT-eLABa-0001:E.02~2005~D_20050524_163850-89727.

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IT industry all time is looking for ways to improve software development productivity as well as the quality and longevity of the software that it creates. OMG announced Model Driven Architecture as its strategic direction. It is software development methodology that provides new viewpoint in software development process. The modeling of problem domain and model transformation are key elements of MDA architecture and they are analyzed in this work using OMG specifications and other resources. The purpose of this work is to evaluate benefits of MDA framework in software development process. The new MDA framework is developed according to the results of MDA architecture analysis. Experimental usage of new MDA framework concentrates on productivity of software development process, automation of repeated tasks and required skill set of application developers.
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Michl, Zbyněk. "T-Mobile MDA II v Linuxu." Master's thesis, Vysoké učení technické v Brně. Fakulta informačních technologií, 2009. http://www.nusl.cz/ntk/nusl-236630.

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MSc. thesis deals with mobile digital assistant T-Mobile MDA II running Linux operating system. The first part presents device identification and parameters' specification of the MDA II. The second part focuses on selection of GNU distribution with Linux bootloader and Linux kernel support comparison. The subject of the last part is MDA II component code implementation and its merging into Linux kernel.
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Becker, Steffen. "Coupled model transformations for QoS enabled component-based software design." Karlsruhe Univ.-Verl. Karlsruhe, 2008. http://d-nb.info/990667650/04.

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Books on the topic "MDA"

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Aaron, Mnguni, ed. Imidlalo kaZakes Mda. Yunivesithi yeSewula Afrika, 2003.

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Z, Ntuli D. B., and AALRDISA (Organization), eds. Imidlalo kaZakes Mda: IsiZulu. Yunivesithi yaseNingizimu Afrika, 2002.

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adom, Magen Daṿid. Le Passeport du MDA. Magen David Adom, 2002.

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K, Moropa C., and AALRDISA (Organization), eds. Imidlalo kaZakes Mda: IsiXhosa. Yunivesithi yaseMzantsi Afrika, 2002.

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Mda, Zakes. Imidlalo yaZakes Mda: SiSwati. Nyuvesi yeNingizimu Afrika, 2002.

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Heritage, English, Royal Commission on Historical Monuments (England), and Museum Documentation Association (Great Britain). Archaelogical Objects Thesaurus Working Party., eds. MDA archaeological objects thesaurus. Museum Documentation Association, 1997.

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A, Holm Stuart, and MDA Railway Terminology Working Group., eds. MDA railway object name thesaurus. MDA, 2002.

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Mda, Zakes. Mintlangu ya Zakes Mda: Xitsonga. Yunivhesithi ya Afrika-Dzonga, 2002.

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Andrew, Horn, ed. The plays of Zakes Mda. Ravan Press, 1990.

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United States. Occupational Safety and Health Administration, ed. 4,4' Methylenedianiline (MDA) for general industry. U.S. Dept. of Labor, Occupational Safety and Health Administration, 1992.

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Book chapters on the topic "MDA"

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Shekhar, Shashi, and Hui Xiong. "MDA." In Encyclopedia of GIS. Springer US, 2008. http://dx.doi.org/10.1007/978-0-387-35973-1_772.

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Gohrisch, Jana. "Mda, Zakes." In Kindlers Literatur Lexikon (KLL). J.B. Metzler, 2020. http://dx.doi.org/10.1007/978-3-476-05728-0_16648-1.

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van Gool, Louis, Teade Punter, Marc Hamilton, and Remco van Engelen. "Compositional MDA." In Model Driven Engineering Languages and Systems. Springer Berlin Heidelberg, 2006. http://dx.doi.org/10.1007/11880240_10.

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Ricchiuti, Diego. "MDA Framework." In Game Design Tools. CRC Press, 2022. http://dx.doi.org/10.1201/9781003229438-15.

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Favre, Liliana, and Liliana Martinez. "Formalizing MDA Components." In Lecture Notes in Computer Science. Springer Berlin Heidelberg, 2006. http://dx.doi.org/10.1007/11763864_24.

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Bendraou, Reda, Philippe Desfray, and Marie-Pierre Gervais. "MDA Components: A Flexible Way for Implementing the MDA Approach." In Model Driven Architecture – Foundations and Applications. Springer Berlin Heidelberg, 2005. http://dx.doi.org/10.1007/11581741_6.

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Papajorgji, Petraq J., and Panos M. Pardalos. "MDA with Oliva Nova." In Springer Optimization and Its Applications. Springer US, 2014. http://dx.doi.org/10.1007/978-1-4899-7463-1_15.

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Mazón, Jose-Norberto, and Juan Trujillo. "Data Warehousing Meets MDA." In Annals of Information Systems. Springer US, 2008. http://dx.doi.org/10.1007/978-0-387-87431-9_3.

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Brambilla, Marco, Jordi Cabot, and Manuel Wimmer. "Model-Driven Architecture (MDA)." In Model-Driven Software Engineering in Practice. Springer International Publishing, 2012. http://dx.doi.org/10.1007/978-3-031-02546-4_4.

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Lopata, Audrius, and Martas Ambraziunas. "Knowledge-Based MDA Approach." In Business Information Systems Workshops. Springer Berlin Heidelberg, 2011. http://dx.doi.org/10.1007/978-3-642-25370-6_16.

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Conference papers on the topic "MDA"

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Semerad, V. A. W., F. A. Corsiglia, D. Weaver, and G. Cox. "Testing of Epoxy Adhesives for a Splash-Zone Coating Retrofit System for Marine Pipeline Riser Applications." In CORROSION 2003. NACE International, 2003. https://doi.org/10.5006/c2003-03042.

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Abstract In the 1992/96 Joint Industry Project test program an epoxy adhesive was qualified, which was applicable and curable under water. However, it used a curative, which contained a man-made chemical called MDA (4,4' methylenedianiline). The MDA-containing curative was shown to be carcinogenic and was later withdrawn from the market. After removal of the MDA and reformulation, application and performance properties of epoxies for underwater application and curing were significantly affected. Since the reformulated epoxy adhesives did not meet the properties of the original (MDA-containing) adhesive, the application process for the riser coating retrofit system was significantly affected. An extensive research and testing program was conducted recently to find a suitable and effective replacement. This paper describes and discusses the testing methodology, which was used during the recent evaluation of replacement candidate epoxies.
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"MDA [advertisement]." In 2010 IEEE International Symposium Antennas and Propagation and CNC-USNC/URSI Radio Science Meeting. IEEE, 2010. http://dx.doi.org/10.1109/aps.2010.5562068.

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Andreasen, Christian, and Chung Hye Read. "GEOINT for MDA." In Defense and Security Symposium, edited by Raja Suresh. SPIE, 2007. http://dx.doi.org/10.1117/12.724505.

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Shi, Renhe, Li Liu, Teng Long, Yufei Wu, and G. Gary Wang. "Multi-Fidelity Modeling and Adaptive Co-Kriging Based Optimization for All-Electric GEO Satellite Systems." In ASME 2018 International Design Engineering Technical Conferences and Computers and Information in Engineering Conference. American Society of Mechanical Engineers, 2018. http://dx.doi.org/10.1115/detc2018-85335.

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All-electric GEO satellite systems design is a challenging multidisciplinary design optimization (MDO) problem, which is computation-intensive due to the employment of expensive simulations. In this paper, the all-electric GEO satellite MDO problem with multi-fidelity models is investigated. The MDO problem involving six inter-coupled disciplines is formulated to minimize the total mass of the satellite system subject to a number of engineering constraints. To reduce the computational cost of the multidisciplinary analysis (MDA) process, multi-fidelity transfer dynamics models and finite element analysis (FEA) models are developed for the geosynchronous transfer orbit (GTO) and structure disciplines respectively. To effectively solve the all-electric GEO satellite MDO problem using multi-fidelity models, an adaptive Co-Kriging based optimization framework is proposed. In this framework, the samples from a high-fidelity MDA process are integrated with those from a low-fidelity MDA process to create a Co-Kriging metamodel with moderate computational cost for optimization. Besides, for refining the Co-Kriging metamodels, a multi-objective adaptive infill sampling approach is developed to produce the infill sample points in terms of expected improvement (EI) and probability of feasibility (PF) functions. Optimization results show that the proposed optimization framework can significantly reduce the total mass of satellite system with limited computational budget, which demonstrates the effectiveness and practicality of the multi-fidelity modeling and adaptive Co-Kriging based optimization framework for all-electric GEO satellite systems design.
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Jezequel, J. M., and W. Emmerich. "Panel MDA in practice." In Proceedings. 26th International Conference on Software Engineering. IEEE, 2004. http://dx.doi.org/10.1109/icse.2004.1317491.

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Favre, Liliana, and Claudia Pereira. "Formalizing MDA-Based Refactorings." In 2008 19th Australian Conference on Software Engineering ASWEC. IEEE, 2008. http://dx.doi.org/10.1109/aswec.2008.4483226.

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Verdickt, Tom, Bart Dhoedt, and Frank Gielen. "Incorporating SPE into MDA." In the fourth international workshop. ACM Press, 2004. http://dx.doi.org/10.1145/974044.974063.

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Chard, J. "MDA and systems engineering." In IEE Seminar on UML Systems Engineering. IEE, 2005. http://dx.doi.org/10.1049/ic:20050132.

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Mahdy, Tarek, Abdulaziz Al-Sulaiti, Yasser Abdelqader, Abdelrahman Fikry, Gaffar Hag, and Mohammad I. Ahmad. "A Validated and Applicable Direct Injection LC/MS/MS Method of Fourteen Drugs of Abuse in Urine Samples to Avoid the False Positive/Negative Results of Immunoassay Techniques in Forensic Cases." In Qatar University Annual Research Forum & Exhibition. Qatar University Press, 2020. http://dx.doi.org/10.29117/quarfe.2020.0146.

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Many false positive and false negative results have been detected in immunoassay analyses of drugs of abuse in urine samples. A method of direct injection of diluted urine into LC/MS/MS was developed and validated for detection and quantitation of Amphetamine, Methamphetamine, MDMA, MDA, Benzoylecgonine, Ecgonine, Norpseudoephedrine, Ephedrine, Tapentadol, Tramadol, O-desmethyltramadol, Tapentadol, Pregabline, Gabapentine and Methadone to avoid the false positive and false negative results in urine samples. Linearity of Amphetamine, Methamphetamine MDMA, MDA, Benzoylecgonine, Ecgonine, Norpseudoephedrine and Ephedrine was (60-2400ng/mL), for Tapentadol, Tramadol, O-desmethyltramadol, and Methadone was (50-1600 ng/mL), and for Pregabline and Gabapentine was (100-4000ng/mL) and r2 ˃ 0.992 for all analysts. A 440 urine samples have been analyzed using both immunoassay technique and LC/MS/MS by direct injection method giving a good comparison to illustrate how this method was specific, accurate, precise, and applicable for forensic urine samples
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Singh, Yashwant, and Manu Sood. "Models and Transformations in MDA." In 2009 First International Conference on Computational Intelligence, Communication Systems and Networks (CICSYN). IEEE, 2009. http://dx.doi.org/10.1109/cicsyn.2009.52.

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Reports on the topic "MDA"

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Hodgkiss, William S. MDA-1 Data Analysis and Report. Defense Technical Information Center, 1995. http://dx.doi.org/10.21236/ada306522.

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Castro, Richard G., and Raymond L. Flesner. LANL/UK Mutual Defense Agreement (MDA) Program. Office of Scientific and Technical Information (OSTI), 2012. http://dx.doi.org/10.2172/1055241.

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Wilson, III, George R., and Nigil Jeyashekar. Metal Deactivator Additive (MDA) Impacts on Thermal Stability. Coordinating Research Council, Inc., 2010. http://dx.doi.org/10.21813/crcav-6-06.

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Hodgkiss, William S. VAST and MDA-1 Experiment Support and Data Analysis. Defense Technical Information Center, 1995. http://dx.doi.org/10.21236/ada306712.

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Toutin, Th, K. E. Mattar, B. Brisco, A. L. Gray, and M J Manore. PRODUCCIÓN DE MDA A PARTIR DE RADARSAT: PANORAMA Y EJEMPLOS. Natural Resources Canada/ESS/Scientific and Technical Publishing Services, 2000. http://dx.doi.org/10.4095/219725.

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Springer, E. P. Surface water and erosion calculations to support the MDA G performance assessment. Office of Scientific and Technical Information (OSTI), 1997. http://dx.doi.org/10.2172/444073.

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Green, Darren C. MDA B Characterization and Remediation Geospatial Materials for Portage, Inc. External Marketing. Office of Scientific and Technical Information (OSTI), 2013. http://dx.doi.org/10.2172/1088357.

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Sarkar, Devanand, and Paul B. Fisher. Characterization of a Novel Tumor Suppressor Gene, mda-7, and its Ability to Induce Apoptosis. Defense Technical Information Center, 2002. http://dx.doi.org/10.21236/ada409484.

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Warren, R. G., E. V. McDonald, and R. T. Ryti. Baseline geochemistry of soil and bedrock Tshirege Member of the Bandelier Tuff at MDA-P. Office of Scientific and Technical Information (OSTI), 1997. http://dx.doi.org/10.2172/563234.

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Szwed, Paul, Yvan Gauthier, and Rafael Matos. Analytic Support for Maritime Domain Awareness and Counter-Piracy. Working Group 4: MDA in National Waters. Defense Technical Information Center, 2009. http://dx.doi.org/10.21236/ada535590.

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