Relevant bibliographies by topics / MDD 93

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Academic literature on the topic 'MDD 93'

Author: Grafiati
Published: 4 June 2021
Last updated: 2 February 2022

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Journal articles on the topic "MDD 93"

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Ageely, Ghofran, Carolina Souza, Kaissa De Boer, Saly Zahra, Marcio Gomes, and Nha Voduc. "The Impact of Multidisciplinary Discussion (MDD) in the Diagnosis and Management of Fibrotic Interstitial Lung Diseases." Canadian Respiratory Journal 2020 (August 17, 2020): 1–6. http://dx.doi.org/10.1155/2020/9026171.

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Accurate diagnosis of interstitial lung disease (ILD) is crucial for management and prognosis but can be challenging even for experienced clinicians. Expert multidisciplinary discussion (MDD) is considered the reference standard for ILD diagnosis; however, there remain concerns regarding lack of validation studies and relative limited information on the impact of MDD in real-life clinical practice. The goal of this study was to assess the effect of MDD in providing a specific ILD diagnosis, changing the diagnosis provided upon referral, and to determine how often and in which way MDD altered management. Material and Methods. Retrospective observational study in an ILD referral tertiary academic center. MDD diagnoses were categorized as specific, provisional, and unclassifiable ILD. Pre-MDD and MDD diagnoses were compared for change in diagnosis and concordance rates for specific diagnoses. Relevant change in management including initiation or change in pharmacological treatment, referral to surgical biopsy, and nonpharmacological management were recorded. Results. 126 cases were included (79M, 47F, 36–93 years, mean 70 y). Specific MDD diagnosis was provided in 62% (78/126); 12% (15/126) had provisional diagnosis, and 21% (27/126) was unclassifiable. Overall agreement for specific pre-MDD and MDD diagnosis was 41% (52/126) and 80% for idiopathic pulmonary fibrosis (IPF) diagnosis. MDD altered diagnosis in 37% (47/126) and changed management in 39% (50/126). Amongst concordant diagnoses, management was altered in 46% (24/52). In summary, MDD provided a specific diagnosis discordant with pre-MDD diagnosis in a significant proportion of cases and was particularly valuable in the diagnosis of non-IPF ILD. MDD often altered management and had relevant impact on management even in cases with concordant pre-MDD diagnosis.
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Chakrabarty, Trisha, Kate L. Harkness, Shane J. McInerney, et al. "Childhood maltreatment and cognitive functioning in patients with major depressive disorder: a CAN-BIND-1 report." Psychological Medicine 50, no. 15 (2019): 2536–47. http://dx.doi.org/10.1017/s003329171900268x.

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AbstractBackgroundPatients with major depressive disorder (MDD) display cognitive deficits in acutely depressed and remitted states. Childhood maltreatment is associated with cognitive dysfunction in adults, but its impact on cognition and treatment related cognitive outcomes in adult MDD has received little consideration. We investigate whether, compared to patients without maltreatment and healthy participants, adult MDD patients with childhood maltreatment display greater cognitive deficits in acute depression, lower treatment-associated cognitive improvements, and lower cognitive performance in remission.MethodsHealthy and acutely depressed MDD participants were enrolled in a multi-center MDD predictive marker discovery trial. MDD participants received 16 weeks of standardized antidepressant treatment. Maltreatment and cognition were assessed with the Childhood Experience of Care and Abuse interview and the CNS Vital Signs battery, respectively. Cognitive scores and change from baseline to week 16 were compared amongst MDD participants with (DM+, n = 93) and without maltreatment (DM−, n = 90), and healthy participants with (HM+, n = 22) and without maltreatment (HM−, n = 80). Separate analyses in MDD participants who remitted were conducted.ResultsDM+ had lower baseline global cognition, processing speed, and memory v. HM−, with no significant baseline differences amongst DM−, HM+, and HM− groups. There were no significant between-group differences in cognitive change over 16 weeks. Post-treatment remitted DM+, but not remitted DM−, scored significantly lower than HM− in working memory and processing speed.ConclusionsChildhood maltreatment was associated with cognitive deficits in depressed and remitted adults with MDD. Maltreatment may be a risk factor for more severe and persistent cognitive deficits in adult MDD.
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Mussolin, Lara, Marta Pillon, Emanuele S. G. d'Amore, et al. "Minimal Disseminated Disease in High-Risk Burkitt's Lymphoma Identifies Patients With Different Prognosis." Journal of Clinical Oncology 29, no. 13 (2011): 1779–84. http://dx.doi.org/10.1200/jco.2010.32.8161.

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Purpose To study minimal disseminated disease (MDD) in children with Burkitt's lymphoma (BL) and to determine its impact on prognosis. Patients and Methods We established a simplified long-distance polymerase chain reaction (LD-PCR) assay that can amplify up to 15 to 20 Kb of DNA sequence, making it possible to detect the t(8;14) at the genomic level with sensitivity of 10−4. We prospectively studied diagnostic biopsies and bone marrow aspirates from 134 patients affected by BL. Results A specific LD-PCR product was detected in 96 (72%) of 134 BL biopsies. Among 84 patients with t(8;14) positivity on tumor biopsy and bone marrow (BM), 26 (31%) had LD-PCR–positive BM, and 15 (18%) were positive at standard morphologic analysis. Twenty (85%) of 26 MDD-positive patients belonged to the R4 risk group, according to Berlin-Frankfurt-Munster definition. The 3-year progression-free survival was 68% (SE, 10%) in MDD-positive patients in R4 compared with 93% (SE, 5%) in MDD-negative patients in R4 (P = .03). By multivariate analysis (including MDD, sex, lactate dehydrogenase, CNS involvement), only MDD was predictive of higher risk of failure (hazard ratio, 4.7; P = .04). Conclusion MDD identifies a poor-prognosis subgroup among children with high-risk BL. To improve disease control in these patients, a more effective risk-adapted therapy, possibly including anti-CD20 monoclonal antibody, should be considered.
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de Jong, Simone, Stephen J. Newhouse, Hamel Patel, et al. "Immune signatures and disorder-specific patterns in a cross-disorder gene expression analysis." British Journal of Psychiatry 209, no. 3 (2016): 202–8. http://dx.doi.org/10.1192/bjp.bp.115.175471.

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BackgroundRecent studies point to overlap between neuropsychiatric disorders in symptomatology and genetic aetiology.AimsTo systematically investigate genomics overlap between childhood and adult attention-deficit hyperactivity disorder (ADHD), autism spectrum disorder (ASD) and major depressive disorder (MDD).MethodAnalysis of whole-genome blood gene expression and genetic risk scores of 318 individuals. Participants included individuals affected with adult ADHD (n = 93), childhood ADHD (n = 17), MDD (n = 63), ASD (n = 51), childhood dual diagnosis of ADHD–ASD (n = 16) and healthy controls (n = 78).ResultsWeighted gene co-expression analysis results reveal disorder-specific signatures for childhood ADHD and MDD, and also highlight two immune-related gene co-expression modules correlating inversely with MDD and adult ADHD disease status. We find no significant relationship between polygenic risk scores and gene expression signatures.ConclusionsOur results reveal disorder overlap and specificity at the genetic and gene expression level. They suggest new pathways contributing to distinct pathophysiology in psychiatric disorders and shed light on potential shared genomic risk factors.
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Homorogan, Claudia, Virgil Radu Enatescu, Diana Nitusca, Anca Marcu, Edward Seclaman, and Catalin Marian. "Distribution of microRNAs associated with major depressive disorder among blood compartments." Journal of International Medical Research 49, no. 4 (2021): 030006052110066. http://dx.doi.org/10.1177/03000605211006633.

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Objective Major depressive disorder (MDD) is a recurrent disorder with an increasing incidence. Alterations in key signaling pathways of the nervous system, such as the Wnt and MAPK pathways, mediated through microRNAs (miRNAs) provide crucial information regarding the etiopathology of MDD. We aimed to analyze whether the heterogeneity of literature findings regarding differential expression of miRNAs in the blood could arise from their different distributions among blood compartments. Methods We performed a pilot study analyzing the differential expression of miR-26a, miR-494, miR-30c, miR-93, and miR-101 and investigated their levels in white blood cells, total plasma (TP), exosomes from plasma, and exosome depleted plasma (EDP) in patients with MDD before and after antidepressant treatment with escitalopram and in healthy controls. Results MiR-494 was more abundant in EDP, and miR-26a and miR-30c were predominantly more abundant in TP relative to other blood compartments. Moreover, miR-30c, miR-101, and miR-26a, were significantly downregulated in TP of patients with MDD compared with controls. After antidepressant treatment, only miR-494 was significantly differently expressed in EDP. Conclusions This proof-of-principle study suggests that identifying the miRNA abundance in different blood compartments is crucial for biomarker development and could enrich the current knowledge regarding MDD pathophysiology.
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Fennema, Peter, and Hassan Achakri. "Getting your devices ready for MDR compliance – a clinical approach and orthopaedic device manufacturers’ perspective." AboutOpen 6, no. 1 (2019): 70–75. http://dx.doi.org/10.33393/abtpn.2019.294.

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On 26 May 2017, the Medical Devices Regulation (MDR 2017/745) was published, with the aim of replacing the current Medical Devices Directive (MDD 93/43/EC). Following a transition period of 3 years, this regulation will be applied in full from 26 May 2020. This article describes and discusses the impact of MDR on the clinical evaluation and gives advice to manufacturers on the preparation, planning and implementation of processes to support compliance with the new regulation. (HTA & Market Access)
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Hughes, Timothy, S. Branford, J. Reynolds, et al. "Higher-Dose Imatinib (600 mg/Day) with Selective Intensification in Newly Diagnosed CML Patients in Chronic Phase; Cytogenetic Response Rates at 12 Months Are Superior to IRIS." Blood 104, no. 11 (2004): 1001. http://dx.doi.org/10.1182/blood.v104.11.1001.1001.

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Abstract The IRIS trial demonstrated that imatinib at 400 mg/day was superior to alpha interferon as first line therapy for chronic phase CML. To assess the tolerability and efficacy of higher doses of imatinib in this setting we are conducting a Phase II trial (TIDEL) using imatinib 600 mg initially, increasing to 800 mg if specified response criteria are not met: complete hematologic response (CHR) at 3 Mo; major cytogenetic response (MCR) at 6 Mo; complete cytogenetic response (CCR) at 9 Mo, and >4 log reduction in BCR-ABL at 12 Mo. Filgrastim was used in cases of neutropenia to maintain dose intensity. Of 103 patients enrolled, 8 came off study in the first 12 Mo (2 unrelated deaths, 3 blast crisis, 3 poor response). 80 patients are currently assessable at 12 Mo (median age 47 years, range 21–75). Protocol mandated dose increases to 800 mg for failure to achieve MCR or CCR targets were activated in 7 patients before 12 months. We made a historical comparison of the best response by 12 Mo to responses in the IRIS trial (95% confidence intervals). Response rates at 12 Mo MCR (0–35% Ph+) CCR (0% Ph+) MMR (≥3 log reduction in BCR-ABL) 400mg - imatinib arm of IRIS n=556 84.1% (81.0 – 87.2%) 69.3% (65.3 – 73.2%) 40% (NA) 600mg - imatinib in TIDEL trial n=80 94.2% (87.3 – 97.5%) 88.5% (80.3 – 93.5%) 47.4% (37.5 – 57.6%) P-value for z-test 0.0004 <0.0001 NA Patients who had a mean daily dose (MDD) <600 mg in the first 2 months (n=27) had a CCR rate at 12 months of 78%, significantly lower than the 12 month CCR rate of 93% in patients receiving a MDD of 600 mg (n=75)(P=0.0015, log-rank test). Within the subgroup of patients receiving a MDD <600 mg in the first 2 Mo who subsequently received a MDD of 600 mg in months 2–6 the CCR rate at 12 Mo remained 73% (n=11) (P=0.004, log rank test). The probability of achieving MMR by 12 Mo was analysed according to the MDD of imatinib received in the first 6 Mo. Patients with a MDD of 600 mg had a probability of 58% (CI 45–71%) (n=62) of achieving MMR compared to 33% (CI 15–59%) in those with a MDD of 500 – 599 mg (n=17) and 32% in those with a MDD of <500 mg (n=20). Given these marked differences even at a MDD of 500–599 mg we looked at the median Sokal score in each group to see if more poor risk patients were present in the groups receiving reduced dose. Median Sokal scores for the groups with MDD of 600mg, 500–599 mg and <500 mg were no different − 0.94, 1.08; and 1.04 respectively. BCR-ABL mutations were detected in 7 patients within 12 Mo (2 had blast crisis, 1 lost CHR, 2 lost CCR and 2 maintain CCR on an increased imatinib dose). Mutation was the main cause of loss of response (5 of 8 patients). We conclude that cytogenetic response rates at 12 Mo are significantly superior to responses observed in the IRIS trial. Major molecular responses are frequent in the cohort able to tolerate a MDD of 600mg. The substantially lower rate of MMR in patients with a moderately reduced MDD was unexpected. These patients did not have less favourable CML biology based on Sokal scores. Although it is possible that other adverse prognostic factors were an influence in these patients, it suggests that dose intensity may be critically important to maximise molecular response.+
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Papmeyer, M., J. E. Sussmann, J. Hall, et al. "Neurocognition in individuals at high familial risk of mood disorders with or without subsequent onset of depression." Psychological Medicine 45, no. 15 (2015): 3317–27. http://dx.doi.org/10.1017/s0033291715001324.

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BackgroundNeurocognitive performance deficits have been observed in mood disorder patients and their unaffected relatives and may therefore qualify as endophenotypes. However, the precise time course of neurocognitive deficits has not been studied so that it is unknown whether neurocognitive abnormalities reflect the early effects of familial vulnerability to mood disorders or if they emerge at illness onset.MethodA neuropsychological test battery was administered at baseline and after a 2-year follow-up interval in 111 initially unaffected young adults at high familial risk of mood disorders and 93 healthy controls (HC). During the follow-up period, 20 high-risk subjects developed major depressive disorder (HR-MDD), with the remainder remaining well (HR-well). Linear mixed-effects models were used to investigate differences and longitudinal changes in the domains of attentional processing, working memory, verbal learning and memory, and cognitive flexibility.ResultsReduced long delay verbal memory and extradimensional set-shifting performance across both time points were found in the HR-well group relative to controls. The HR-MDD group displayed decreased extradimensional set-shifting abilities across both time points as compared with the HC group only. There were no significant performance differences between the two high-risk groups.ConclusionsReduced verbal memory and cognitive flexibility are familial trait markers for vulnerability to mood disorders in individuals with a close family history of bipolar disorder. Both neurocognitive performance deficits appear to be relatively stable over a 2-year time period and do not appear to be linked to the onset of MDD. These findings support their use as stable quantitative endophenotypes for mood disorders.
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Lavori, Philip W., Meredith Warshaw, Gerald Klerman, et al. "Secular trends in lifetime onset of MDD stratified by selected sociodemographic risk factors." Journal of Psychiatric Research 27, no. 1 (1993): 95–109. http://dx.doi.org/10.1016/0022-3956(93)90054-6.

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Sachs-Ericsson, Natalie J., Greg Hajcak, Julia L. Sheffler, et al. "Putamen Volume Differences Among Older Adults: Depression Status, Melancholia, and Age." Journal of Geriatric Psychiatry and Neurology 31, no. 1 (2017): 39–49. http://dx.doi.org/10.1177/0891988717747049.

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Background: Individuals with major depressive disorder (MDD) may exhibit smaller striatal volumes reflecting deficits in the reward circuit. Deficits may change with age and be more pronounced among the melancholic subtype. Limited research has investigated striatal volume differences in older adults and by depression subtypes. Method: We used baseline data from the Neurocognitive Outcomes of Depression in the Elderly study. We examined volumetric differences in the putamen and caudate nucleus among older adults (60 years and older), comparing healthy control participants (n = 134) to depressed participants (n = 226), and comparing nonmelancholic depressed participants (n = 93) to melancholic depressed participants (n = 133). Group-by-age interactions were examined. Results: There were no significant group differences for the caudate nucleus. For the left putamen, investigation of the significant group-by-age interaction revealed that volume size was greater for the healthy controls compared to the depressed participants but only at younger ages (60-65 years); group differences diminished with increasing age. Examining volume by depression subtype revealed that the melancholic depressed participants had a smaller left putamen compared to the nonmelancholic depressed participants. Anhedonia symptoms were related to both smaller left and right putamen. Conclusion: Structural abnormalities in reward regions may underlie the anhedonic phenotype. Volume loss associated with MDD may attenuate in older age.
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Dissertations / Theses on the topic "MDD 93"

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Bernardino, Patrícia Benvinda Gomes. "Desenvolvimento de um elétrodo para peloterapia." Master's thesis, Universidade de Aveiro, 2014. http://hdl.handle.net/10773/14493.

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Mestrado em Materiais e Dispositivos Biomédicos<br>A sociedade tal como a conhecemos tem assistido ao envelhecimento da sua população. Este facto tem potenciado a crescente evolução na área da Medicina Física e de Reabilitação (MFR) como resposta à procura de soluções terapêuticas para reabilitação e bem-estar. Face à procura constante de uma melhor qualidade de vida, a oferta de cuidados médicos por parte das clínicas de reabilitação tem-se acentuado, sendo a Eletroterapia uma das modalidades terapêuticas mais utilizadas em MFR. Esta modalidade tem-se afirmado pelo seu desempenho terapêutico no tratamento de inúmeras doenças, entre as quais as reumatológicas que são as mais frequentes na população portuguesa de idade avançada. Em Portugal outra modalidade presente na MFR é a Peloterapia que, também apresenta resultados notáveis na melhoria do estado de saúde da população. É em centros termais e spas que esta modalidade é facilmente encontrada, uma vez que a sua aplicação recorre a pelóides que consistem em formulações de águas termais com minerais argilosos. É com base no conhecimento do importante contributo destas duas modalidades para a saúde e bem-estar da nossa sociedade que a empresa Exatronic pretende combinar a Eletroterapia e a Peloterapia para introduzir um novo conceito, a Eletropeloterapia. Usando o know-how que detém no campo da engenharia eletrónica aplicada ao desenvolvimento de dispositivos, a Exatronic propôs um dispositivo que materializa este novo conceito. Nesse contexto, o presente trabalho visa o desenvolvimento de um dispositivo de Eletropeloterapia com aplicação transdérmica de pelóides, para ser introduzido no mercado do termalismo, em spa’s e em centros de MFR. Partindo de uma configuração base pré-definida, estudaram-se e otimizaram-se parâmetros de configuração do protótipo, designadamente: (i) o material envolvente da amostra argilosa (pelóide), (ii) a dimensão do protótipo e (iii) a geometria da resistência de aquecimento. Os ensaios de validação da funcionalidade do protótipo permitiram avaliar as dimensões do mesmo como excessivas, tendo sido necessário corrigi-las para valores mais ajustados à utilização do dispositivo. Por outro lado, a pesquisa sobre materiais médicos têxteis identificou o poliéster como o material mais adequado para o fabrico da bolsa do protótipo, em substituição do algodão inicialmente previsto. Os ensaios de monitorização de temperatura do pelóide sob o efeito de resistências de diferentes geometrias permitiu concluir que a utilização de duas resistências elétricas com configuração sinusoidal assegura o melhor desempenho em termos de manutenção do pelóide à temperatura desejada. Realizaram-se também estudos de condução elétrica através da argila que revelaram um contributo iónico para o transporte de carga elétrica, atribuído a iões argilosos, entre os quais iões de Ca, K, Fe e Mg, que se movimentam entre o ânodo e o cátodo. Por outro lado as concentrações destes elementos que se mediram em regiões distintas da argila (junto a cada um dos elétrodos) corroboram a participação desses catiões na condução de corrente através da argila. Associado ao desenvolvimento de um dispositivo médico é particularmente importante para qualquer fabricante a obtenção da marcação CE necessária à comercialização do mesmo no espaço económico europeu (EEE). Nesse sentido foi também elaborado todo o processo necessário à certificação do dispositivo médico desenvolvido de acordo com a Diretiva Médica (93/42/CEE). Em conclusão, o presente trabalho dá um importante contributo para a concretização do conceito de Eletropeloterapia, conceito este que despertou um elevado interesse dos profissionais familiarizados com Peloterapia segundo o estudo de mercado efetuado.<br>Society as we've known has been watching the population grow and age. It's before this fact that we've been seeing a growing trend of physical and rehabilitation medicine (PRM) as an answer to the demand of therapeutical solutions for rehabilitation and well-being. Due to a constant search for a better life quality, the supply of rehabilitation clinics has been increasing and Electrotherapy is the most used therapeutic modality in PRM.This modality has shown a high terapeutic effect in inumerous deseases, of which rematheulogic deseases are also the most frequent on aged portuguese population. In Portugal, one of the modalities that follow the physical and rehabilitation medicine is Pelotherapy that, as Electrotherapy, shows striking results on population's health. However, it is on thermal centers and spas that this modality can be easily found, as it's application is made through peloids that consist in an solution of clay minerals and thermal water. It's based on these two modalities and the knowledge about the important role that both parts play in our society that we create a new concept, Electropelotherapy which is the junction of Electrotherapy and Pelotherapy. Using the know-how that holds in the field of electronic engineering in the development of devices, Exatronic proposed a device that materializes this new concept. In this context, this work aims at the development of a device Eletropeloterapia with transdermal application of peloids, to be introduced in the hydrotherapy market, spa's facilities and at MFR. Starting from a predefined basic configuration is studied and optimized is the prototype configuration parameters, namely: (i) the surrounding material of the clay sample (pelloid), (ii) the size of the prototype and (iii) the geometry resistance heating. The validation tests the functionality of the prototype allowed evaluation of the dimensions the same as excessive, it was necessary to correct them more suited to the use of the device values. Furthermore, research on the medical textile polyester materials identified as the most suitable material for making the pouch of the prototype, replacing the cotton initially expected. Assays for monitoring temperature pelloid under the effect of resistances of different geometries showed that the use of two electric resistances with a sinusoidal configuration provides optimum performance in terms of maintaining the desired temperature of the pelloid. Studies were also carried out electrical conduction through clay which showed an ion for transport of electric charge contribution allocated to clay ions including ions of Ca, K, Fe and Mg, which move between the anode and cathode. Furthermore the concentrations of these elements were measured at different regions of the clay (with each of the electrodes) corroborate the role of these cations in the conduction of current through the clay. Associated with the development of a medical device is particularly important for any manufacturer to obtain the CE marking required for marketing the same in the European Economic Area (EEA). In this regard was also prepared all the necessary certification of medical device developed according to Medical Directive (93/42/EEC) process. In conclusion, this study is an important contribution to the realization of the concept of Eletropeloterapia, a concept that sparked a high interest from professionals familiar with Peloterapia according to market research conducted.
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Foe, Owono Guy. "Impact of EU Medical Device Directive on Medical Device Software." ScholarWorks, 2015. https://scholarworks.waldenu.edu/dissertations/353.

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Directive 2007/47/EC of the European Parliament amending Medical Device Directive (MDD) provides medical device manufacturers with a compliance framework. However, the effects of the amendments to the MDD on competition in the U.S. medical device software industry are unknown. This study examined the impact of this directive on the competitiveness of U.S. medical device software companies, the safety and efficacy of medical device software, employee training, and recruitment. The conceptual framework for this study included 3 dimensions of medical device regulations: safety, performance, and reliability. The overall research design was a concurrent mixed method study using both quantitative and qualitative techniques. The qualitative techniques involved case studies of 5 purposively selected companies. Data collection involved both surveys and interviews. The sample consisted of 56 employees within medical device firms with markets around the European regions. Qualitative data analysis consisted of descriptive thematic analysis along the study questions and hypotheses and summative evaluation. Quantitative data analysis included descriptive statistics and correlation to test the 4 hypotheses. The results suggested that the MDD has realigned medical device software manufacturing practices, and US medical device companies have gained global competitiveness in improving product safety and increasing sales revenue. Key recommendations to medical device manufacturers include adopting MDD 93/42/EEC, using model-based approaches, and being comprehensive in model use. Adopting the MDD will provide positive social change to patients, as human safety improves with better product quality while companies experience fewer product recalls.
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Carlsson, Björn. "From achiral to chiral analysis of citalopram /." Linköping : Univ, 2003. http://www.ep.liu.se/diss/med/07/93/index.html.

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Nordegren, Annica. "Design som teori och empiri: ett designteoretiskt forskningsprojekt med en prototyputveckling av ett symbolsystem för vinsmaker /." Stockholm : KTH Arkitekturskolan, 2004. http://urn.kb.se/resolve?urn=urn:nbn:se:kth:diva-93.

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Frohm, Markus. "Hanteringen av avtal i strid med lag eller goda seder - en kartläggning och en kritik." Thesis, Uppsala universitet, Juridiska institutionen, 2021. http://urn.kb.se/resolve?urn=urn:nbn:se:uu:diva-431934.

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Ekstrand, Johan, and Jennifer Landström. "Den inre digitala marknadens framtid : Medlemsstaternas dilemma med implementeringen av upphovsrättsdirektivet: fokus på svensk respektive fransk rätt." Thesis, Linköpings universitet, Filosofiska fakulteten, 2020. http://urn.kb.se/resolve?urn=urn:nbn:se:liu:diva-169309.

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Upphovsrättsdirektivet, Digital Single Market-direktivet, befinner sig idag i en implementeringsprocess i EU-länderna. Implementeringen syftar till att harmonisera upphovsrätten mellan medlemsstaterna och att upprätthålla en väl fungerande inre marknad. Direktivet medför ett antal dilemman vid harmoniseringen av medlemsländernas lagstiftningar. Somliga länder är positiva till direktivet, medan andra anmärker en ordalydelse som är otydlig, abstrakt och svår att konkretisera. Frankrike var första land inom unionen att lägga fram ett lagförslag baserat på direktivet. Samtliga medlemsländer, däribland Sverige, har fortfarande tid på sig att införliva direktivet i sin lagstiftning. Syftet med uppsatsen är att utreda DSM-direktivets artikel 17 och dess implementering i fransk rätt med utgångspunkt i Frankrikes framställda lagförslag. Vidare är ändamålet att göra en konkret jämförelse mellan förevarande upphovsrättsliga normer i Sverige respektive Frankrike, för att således kunna analysera det franska lagförslagets lämplighet i svensk rättsordning. Lämpligheten ska försöka bedömas utifrån kulturella värderingar bakom nationell lagstiftning och upphovsrättspolitik. För att besvara frågeställningen huruvida det franska lagförslaget på implementering av DSM-direktivets artikel 17 kan vara en förebild för den svenska lagstiftaren, har framställningen disponerats enligt följande: vi har (1) utrett svensk upphovsrätt, (2) redogjort för DSM-direktivet och härrörande kritik, (3) uppgivit Regeringskansliets resonemang och frågeställningar gällande direktivets genomförande i svensk rätt, (4) utrett fransk upphovsrätt samt (5) översatt och tolkat förevarande lagförslag med tillhörande kritik. Utöver rättskällor, har framställningen till övervägande del grund i debattartiklar, tidskrifter samt inlägg online för att klargöra den aktuella problematiken rörande DSM-direktivet. Slutsatsen är att svensk respektive fransk upphovsrätt visserligen framstår som snarlika i stort sett. Däremot kan det franska lagförslaget på implementering av direktivet enbart framstå som en förebild i viss mån. Av artikel 17:s tre huvudområden kan vägledning av det franska lagförslaget endast ges gällande införandet av en klagomåls- och avhjälpningsmekanism.<br><p>Det här är den slutgiltiga examensuppsatsen, en nedskuren version av en mer omfattande och djupgående version. För intressenter finns den första versionen tillgänglig via kontakt med författarna. </p>
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Books on the topic "MDD 93"

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Diane, Lees, and International Conference on Hypermedia and Interactivity in Museums (2nd : 1993 : Cambridge, England), eds. Museums and interactive multimedia: Proceedings of an international conference held in Cambridge, England, 20-24 September 1993 : the Sixth International Conference of the MDA and the Second International Conference on Hypermedia and Interactivity in Museums (ICHIM '93). Museum Documentation Association, 1993.

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Magazine, Mad, and Editors Mad. Bristling Mad (Mad, No 93). Warner Books, 1993.

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Scoutt, Leslie M., Ulrike M. Hamper, and Teresita L. Angtuaco. Case 93. Oxford University Press, 2017. http://dx.doi.org/10.1093/med/9780199988105.003.0093.

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This is a case from the Abdomen section of Ultrasound. The specific content of each case and its diagnosis are necessarily hidden from this abstract. Each case contains case history, followed immediately by the diagnosis, which is supported with findings, differential diagnosis, teaching points, management, and further reading suggestions.
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Lockhart, Mark E., and Rupan Sanyal. Case 93. Oxford University Press, 2015. http://dx.doi.org/10.1093/med/9780199975747.003.0093.

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This is a case from the Testis, Epididymis, and Scrotum section of Genitourinary Imaging Cases. The specific content of each case and its diagnosis are necessarily hidden from this abstract. Each case contains case history, followed immediately by the diagnosis, which is supported with findings, differential diagnosis, teaching points, management, and further reading suggestions.
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Book chapters on the topic "MDD 93"

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Lehtokangas, Mikko, Jukka Saarinen, Pentti Huuhtanen, and Kimmo Kaski. "Neural Network Modeling and Prediction of Multivariate Time Series Using Predictive MDL Principle." In ICANN ’93. Springer London, 1993. http://dx.doi.org/10.1007/978-1-4471-2063-6_233.

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den Boer, Bert, and Antoon Bosselaers. "Collisions for the compression function of MD5." In Advances in Cryptology — EUROCRYPT ’93. Springer Berlin Heidelberg, 1994. http://dx.doi.org/10.1007/3-540-48285-7_26.

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"The Medical Devices Directive (93/42/EEC)." In MDD Compliance Using Quality Management Techniques. Routledge, 2012. http://dx.doi.org/10.4324/9780080523156-6.

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Brant, William E., and Eduard E. de Lange. "Case 93." In Body MRI Cases. Oxford University Press, 2013. http://dx.doi.org/10.1093/med/9780199740710.003.0093.

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Appleton, Catherine M., and Kimberly N. Wiele. "Case 93." In Breast Imaging Cases. Oxford University Press, 2011. http://dx.doi.org/10.1093/med/9780199731923.003.0093.

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Eskey, Clifford J., Clifford J. Belden, David A. Pastel, Arastoo Vossough, and Albert J. Yoo. "Case 93." In Neuroradiology Cases. Oxford University Press, 2012. http://dx.doi.org/10.1093/med/9780199735983.003.0093.

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"Case 93." In Gastrointestinal Imaging Cases, edited by Angela D. Levy, Koenraad Mortele, and Benjamin M. Yeh. Oxford University Press, 2013. http://dx.doi.org/10.1093/med/9780199759439.003.0093.

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Jacene, Heather A., Chun K. Kim, Christopher G. Sakellis, and Katherine A. Zukotynski. "Case 93." In Nuclear Medicine and PET/CT Cases. Oxford University Press, 2015. http://dx.doi.org/10.1093/med/9780199773695.003.0093.

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"Case 93." In Emergency Radiology Cases, edited by Hani H. Abujudeh. Oxford University Press, 2014. http://dx.doi.org/10.1093/med/9780199941179.003.0093.

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Anderson, Mark W., and Stacy E. Smith. "Case 93." In Musculoskeletal Imaging Cases. Oxford University Press, 2013. http://dx.doi.org/10.1093/med/9780195394375.003.0093.

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Conference papers on the topic "MDD 93"

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Shiau, Ting Nung, Chun Pao Kuo, G. J. Sheu, and P. L. Kuo. "A Study on New Identification Technique With Application to Squeeze Film Bearing System." In ASME 1993 International Gas Turbine and Aeroengine Congress and Exposition. American Society of Mechanical Engineers, 1993. http://dx.doi.org/10.1115/93-gt-060.

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Two identification techniques, which are the Method of Feasible Directions (MFD) based on optimization concept and the Hybrid Method (HM) combining the merits of the State Variable Filter method (SVF) and MFD, are proposed for the parameters identification of rotor system with squeeze-film damper (SFD). The parameters of SFD, including hydrodynamic inertia, damping and stiffness, are identified and the results obtained by using MFD and HM are compared to those using SVF. The accuracy and efficiency of using these techniques are demonstrated by the experimental simulation with various noise levels and different initial values. The results indicate that the choice of initial values is of no significant effect on SVF method and the accuracy of SVF depends on the level of noise. However, for MFD method, it is almost independent of noise effect but significantly affected by the choice of initial values. The Hybrid Method (HM) is proposed to overcome these handicaps and found of better accuracy and efficiency than SVF and MFD. Then, it is highly recommended for the parameters identification of system with noise effect.
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"Message from the PhD Forum Chairs." In 2019 20th IEEE International Conference on Mobile Data Management (MDM). IEEE, 2019. http://dx.doi.org/10.1109/mdm.2019.00-93.

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Goldbeck, Robert A., and David S. Kliger. "Monitoring protein dynamics with time-resolved CD and MCD spectroscopy." In OE/LASE'93: Optics, Electro-Optics, & Laser Applications in Science& Engineering, edited by Laurence A. Nafie and Henry H. Mantsch. SPIE, 1993. http://dx.doi.org/10.1117/12.145257.

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Huang, Wan-Jou, Wei-Fan Chang, Chia-Chien Wei та ін. "93% Complexity Reduction of Volterra Nonlinear Equalizer by ℓ1-Regularization for 112-Gbps PAM-4 850-nm VCSEL Optical Interconnect". У Optical Fiber Communication Conference. OSA, 2018. http://dx.doi.org/10.1364/ofc.2018.m2d.7.

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Badger, M., A. Julien, A. D. LeBlanc, S. H. Moustapha, A. Prabhu, and A. A. Smailys. "The PT6 Engine: 30 Years of Gas Turbine Technology Evolution." In ASME 1993 International Gas Turbine and Aeroengine Congress and Exposition. American Society of Mechanical Engineers, 1993. http://dx.doi.org/10.1115/93-gt-006.

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The PT6 engine entered service in the mid-1960’s. Since then, application of new technology, has enabled low cost development of engines approaching 1500 KW, the introduction of electronic controls, improved power-to-weight ratio, higher cycle temperature and reduced specific fuel consumption. At the same time, PT6 field experience in business, commuter, helicopter and trainer applications has resulted in engines with low Direct Operating Cost and a reputation for rugged design and a high standard of engine reliability. This paper will highlight some interesting examples of this technical evolution, including the development of electronic controls and the application of the latest 3D aerodynamic and stress analysis to both compressor and turbine components.
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Lewis, K. L. "Spanwise Transport in Axial-Flow Turbines: Part 1 — The Multistage Environment." In ASME 1993 International Gas Turbine and Aeroengine Congress and Exposition. American Society of Mechanical Engineers, 1993. http://dx.doi.org/10.1115/93-gt-289.

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Selected experimental results, obtained from a detailed investigation into the flowfields within two low speed multistage turbines, are presented. A repeating stage condition occurred typically after two stages, with the secondary flows an important factor in the low aspect ratio geometry. A tracer gas technique was employed to identify the dominant mechanisms of spanwise transport and their relative significance. In the first stages of both machines, tracer transport was more intense near the endwalls than at mid-span whilst in the multistage environment the transport was approximately constant across the whole span. The convective influence of classical secondary flow, shroud leakage and wake passage through a downstream blade was identified and shown to be as significant as turbulent diffusion in effecting cross-passage and spanwise transport. The data show that spanwise transport should be included within any throughflow model and are used to calibrate two scaling models. These models are presented in Part 2 where the influence of incorporating spanwise transport into a throughflow model is investigated.
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Wang, Shuo, and Xijun Huang. "Investigation on Suppression of the Dynamic Distortion of 2-D Diffuser." In ASME 1993 International Gas Turbine and Aeroengine Congress and Exposition. American Society of Mechanical Engineers, 1993. http://dx.doi.org/10.1115/93-gt-135.

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Three passive control methods of dynamic total pressure distortion have been developed in a 2–D diffuser in this paper: a fore–positioned shock stabilizing rod on a porous plate (model Q), a mid–positioned shock stabilizing rod on a porous plate (model Z), a porous plate (model K) and the original model without any control. From the experiment results, we observe that the PCSB (Passive Control of Shock wave / Boundary layer) technique used in the diffuser is effective to decrease the dynamic distortion. We conclude that: a) Different flow regions and their characteristic frequencies in the diffuser have been found. b) The interaction between the terminal shock wave and the boundary layer produces the peak value of the dynamic distortion. c) The steady total pressure varies inversely with the dynamic components of the total pressure along the height at the exit of the diffuser. d) The effects of different positions of the shock stabilizing rod on the dynamic distortion are relative to the upstream total pressure of the diffuser. e) New explanation about the production of the distortion has been given.
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Keller, F. Jeffrey, and Ting Wang. "Effects of Criterion Functions on Intermittency in Heated Transitional Boundary Layers With and Without Streamwise Acceleration." In ASME 1993 International Gas Turbine and Aeroengine Congress and Exposition. American Society of Mechanical Engineers, 1993. http://dx.doi.org/10.1115/93-gt-067.

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Attempting to understand the mechanisms of momentum and thermal transports in transitional boundary layers, has resulted in the use of conditional sampling to separate the flow into turbulent and non-turbulent portions. The choice of a proper criterion function to discriminate between the two flow conditions is critical. A detailed experimental investigation was performed to determine the effects of different criterion functions on the determination of intermittency for application in heated transitional boundary layers with and without streamwise acceleration. Nine separate criterion functions were investigated for the baseline case without pressure gradient and three cases with streamwise pressure gradient. Inherent differences were found to exist between each criterion function’s turbulence recognition capabilities. The results indicate that using a criterion function based on Reynolds shear stress, (∂uv∂τ)2, for turbulent/non-turbulent discrimination in a heated transitional boundary layer is superior to a single velocity or temperature scheme. Peak values in intermittency for the early to mid-transitional region were found to occur away from the wall at approximately y/δ = 0.3 for all cases. To match the universal intermittency distribution of Dhawan and Narasimha (1958), the minimum values of intermittency at y/δ ≈ 0.1 should be used as the representative “near-wall” values.
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Gan, Xiaopeng, Muhsin Kilic, and J. Michael Owen. "Flow Between Contra-Rotating Discs." In ASME 1993 International Gas Turbine and Aeroengine Congress and Exposition. American Society of Mechanical Engineers, 1993. http://dx.doi.org/10.1115/93-gt-286.

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The paper describes a combined experimental and computational study of laminar and turbulent flow between contra-rotating discs. Laminar computations produce Batchelor-type flow: radial outflow occurs in boundary layers on the discs and inflow is confined to a thin shear layer in the mid-plane; between the boundary layers and the shear layer, two contra-rotating cores of fluid are formed. Turbulent computations (using a low-Reynolds-number k-ε turbulence model) and LDA measurements provide no evidence for Batchelor-type flow, even for rotational Reynolds numbers as low as 2.2 × 104. Whilst separate boundary layers are formed on the discs, radial inflow occurs in a single interior core that extends between the two boundary layers; in the core, rotational effects are weak. Although the flow in the core was always found to be turbulent, the flow in the boundary layers could remain laminar for rotational Reynolds numbers up to 1.2 × 105. For the case of a superposed outflow, there is a source region in which the radial component of velocity is everywhere positive; radially outward of this region, the flow is similar to that described above. Although the turbulence model exhibited premature transition from laminar to turbulent flow in the boundary layers, agreement between the computed and measured radial and tangential components of velocity was mainly good over a wide range of nondimensional flow rates and rotational Reynolds numbers.
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Haddara, Sherif Hassan. "Expanded SUMED System a Pipeline for the Future." In ASME 1993 International Gas Turbine and Aeroengine Congress and Exposition. American Society of Mechanical Engineers, 1993. http://dx.doi.org/10.1115/93-gt-379.

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This paper describes the Design, Engineering, Planning and Implementation activities that led up to an advanced, state of the art, optimum and economical solution for expanding an existing system to handle an increase of crude oil throughput from 80 to 117 mta metric tons per year (2.53 t/s to 3.71 t/s). The growing demand and reduced net imports of products will increase Western European crude oil requirements to 11 million b/d (barrel per day) equivalent to 20.24 m3/s by year 2000. SUMED (gulf of SUez - MEDiterranean) the Arab Petroleum Pipelines Company has historically secured about 40% of the market for middle Eastern crude oil movements to Europe. Given these market shares on incremental volume SUMED should achieve its maximum design throughput of 117 mta by year 2000. The SUMED pipelines system which is owned and operated by an Arab company having EGYPT, SAUDI ARABIA, KUWAIT, EMIRATES AND QATAR as share holders has been in operation since 1977. An expansion project has started to increase the throughput capacity of the system from 80 to 117 mta. The project completion is expected by mid 1994 with a total expenditure of 120 million dollars. This paper reviews the evaluation and selection of various electric motor and gas turbines for the main pumping station addition for this pipeline expansion.
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