Relevant bibliographies by topics / MDeNM / Journal articles
To see the other types of publications on this topic, follow the link: MDeNM.

Journal articles on the topic 'MDeNM'

Author: Grafiati
Published: 25 May 2024

Create a spot-on reference in APA, MLA, Chicago, Harvard, and other styles

Select a source type:

Consult the top 46 journal articles for your research on the topic 'MDeNM.'

Next to every source in the list of references, there is an 'Add to bibliography' button. Press on it, and we will generate automatically the bibliographic reference to the chosen work in the citation style you need: APA, MLA, Harvard, Chicago, Vancouver, etc.

You can also download the full text of the academic publication as pdf and read online its abstract whenever available in the metadata.

Browse journal articles on a wide variety of disciplines and organise your bibliography correctly.

1

Costa, Mauricio G. S., Charline Fagnen, Catherine Vénien-Bryan, and David Perahia. "A New Strategy for Atomic Flexible Fitting in Cryo-EM Maps by Molecular Dynamics with Excited Normal Modes (MDeNM-EMfit)." Journal of Chemical Information and Modeling 60, no. 5 (2020): 2419–23. http://dx.doi.org/10.1021/acs.jcim.9b01148.

Full text
APA, Harvard, Vancouver, ISO, and other styles
2

Mbaoji, Florence Nwakaego, Akachukwu Marytheresa Onwuka, Sunday Onu, Ikechukwu Emmanuel Peter, Justus Amuche Nweze, and Lilian Eleje Okonta. "Evaluation of Methanol-Dichloromethane Extract of Stemonocoleus micranthus Harms (Fabaceae) Stem Bark for Anti-Inflammatory and Immunomodulatory Activities." Evidence-Based Complementary and Alternative Medicine 2020 (May 7, 2020): 1–10. http://dx.doi.org/10.1155/2020/1738163.

Full text
Abstract:
Background. The stem bark decoction of Stemonocoleus micranthus Harms (Fabaceae) is most widely used traditionally as a remedy for various diseases such as malaria and boil. In this study, the anti-inflammatory and immunomodulatory activities of the methanol-dichloromethane extract (MDE) from the stem bark of the plant in rodents were evaluated. Methods. The carrageenan-induced rat paw oedema, cotton pellet-induced granuloma in rat, and xylene-induced ear oedema in mice were used to study the anti-inflammatory activity of methanol-dichloromethane extract of Stemonocoleus micranthus (MDESm) (10
APA, Harvard, Vancouver, ISO, and other styles
3

Senanayake, Bimsara. "Multiphasic disseminating encephalomyelitis (MDEM)." Sri Lanka Journal of Neurology 2, no. 1 (2013): 17. http://dx.doi.org/10.4038/sljon.v2i1.101.

Full text
APA, Harvard, Vancouver, ISO, and other styles
4

Xiao, Jin, Cyril Meyerowitz, Patricia Ragusa, et al. "Assessment of an Innovative Mobile Dentistry eHygiene Model Amid the COVID-19 Pandemic in the National Dental Practice–Based Research Network: Protocol for Design, Implementation, and Usability Testing." JMIR Research Protocols 10, no. 10 (2021): e32345. http://dx.doi.org/10.2196/32345.

Full text
Abstract:
Background Amid COVID-19, and other possible future infectious disease pandemics, dentistry needs to consider modified dental examination regimens that render quality care, are cost effective, and ensure the safety of patients and dental health care personnel (DHCP). Traditional dental examinations, which number more than 300 million per year in the United States, rely on person-to-person tactile examinations, pose challenges to infection control, and consume large quantities of advanced-level personal protective equipment (PPE). Therefore, our long-term goal is to develop an innovative mobile
APA, Harvard, Vancouver, ISO, and other styles
5

Wang, Rui, Jialing Zou, and James Zhiqing Wen. "SFA-MDEN: Semantic-Feature-Aided Monocular Depth Estimation Network Using Dual Branches." Sensors 21, no. 16 (2021): 5476. http://dx.doi.org/10.3390/s21165476.

Full text
Abstract:
Monocular depth estimation based on unsupervised learning has attracted great attention due to the rising demand for lightweight monocular vision sensors. Inspired by multi-task learning, semantic information has been used to improve the monocular depth estimation models. However, multi-task learning is still limited by multi-type annotations. As far as we know, there are scarcely any large public datasets that provide all the necessary information. Therefore, we propose a novel network architecture Semantic-Feature-Aided Monocular Depth Estimation Network (SFA-MDEN) to extract multi-resolutio
APA, Harvard, Vancouver, ISO, and other styles
6

Baumann, Matthias, Eva-Maria Hennes, Kathrin Schanda, et al. "Children with multiphasic disseminated encephalomyelitis and antibodies to the myelin oligodendrocyte glycoprotein (MOG): Extending the spectrum of MOG antibody positive diseases." Multiple Sclerosis Journal 22, no. 14 (2016): 1821–29. http://dx.doi.org/10.1177/1352458516631038.

Full text
Abstract:
Background: Myelin oligodendrocyte glycoprotein (MOG) antibodies have been described in children with acute disseminated encephalomyelitis (ADEM), recurrent optic neuritis, neuromyelitis optica spectrum disorders and more recently in children with multiphasic disseminated encephalomyelitis (MDEM). Objective: To delineate the clinical, cerebrospinal fluid (CSF) and radiological features of paediatric MDEM with MOG antibodies. Methods: Clinical course, serum antibodies, CSF, magnetic resonance imaging (MRI) studies and outcome of paediatric MDEM patients were reviewed. Results: A total of 8 chil
APA, Harvard, Vancouver, ISO, and other styles
7

Cantarelli, Vinícius de Souza, Elias Tadeu Fialho, Raimundo Vicente de Sousa, Rilke Tadeu Fonseca de Freitas, and José Augusto de Freitas Lima. "Composição química, vitreosidade e digestibilidade de diferentes híbridos de milho para suínos." Ciência e Agrotecnologia 31, no. 3 (2007): 860–64. http://dx.doi.org/10.1590/s1413-70542007000300036.

Full text
Abstract:
Objetivou-se avaliar a composição química, vitreosidade e valores nutricionais de diferentes híbridos de milho através de análises laboratoriais e de um ensaio de metabolismo com suínos em crescimento. Foram utilizados 24 suínos em fase de crescimento (35,6 Kg ±± 3,05 kg de PV) machos castrados mestiços (LD x LW), os quais foram mantidos em gaiolas de metabolismo e distribuídos em um delineamento inteiramente ao acaso totalizando 24 parcelas. Os tratamentos experimentais consistiram de 6 rações com os seguintes híbridos de milho: milho óleo (Móleo), milho QPM (MQPM), milho dentado (Mdent), mil
APA, Harvard, Vancouver, ISO, and other styles
8

Prieto-López, Yeimer, Mario Ayala-Pazmiño, and Sedolfo Carrasquero-Ferrer. "Estimulación de los hábitos lectores desde las materias de Metodología de Investigación y Titulación en los estudiantes de la Maestría en Gestión Educativa de la Universidad de Especialidades Espíritu Santo (UEES)." 593 Digital Publisher CEIT 7, no. 1-1 (2022): 317–31. http://dx.doi.org/10.33386/593dp.2022.1-1.977.

Full text
Abstract:
Esta investigación resulta de la experiencia de los investigadores durante tres años consecutivos dictando la materia de Metodología de la Investigación (MR) en la Maestría en Gestión Educativa (MDEM) de la Universidad Espíritu Santo (UEES), detectando los malos hábitos lectores como una de las principales limitantes en los estudiantes. Existe la necesidad de profundizar el componente lector y la producción científica y académica, evidenciado por el diagnóstico aplicado en las diferentes promociones del 2019 al 2022.Para su desarrollo se consultó una extensa bibliografía considerando los vacío
APA, Harvard, Vancouver, ISO, and other styles
9

Pan, Feifei, Xiaohuan Xi, and Cheng Wang. "A MATLAB-based digital elevation model (DEM) data processing toolbox (MDEM)." Environmental Modelling & Software 122 (December 2019): 104566. http://dx.doi.org/10.1016/j.envsoft.2019.104566.

Full text
APA, Harvard, Vancouver, ISO, and other styles
10

Jo, Yun Suk, Do-Kyung Kim, Young Keun Jeong, Kyung Ja Kim, and Mamoun Muhammed. "A Novel Thermosensitive Composite Fabricated with Au Nanoparticles, Poly(Lactide), and Poly(N-Isopropylacrylamide)." Solid State Phenomena 99-100 (July 2004): 161–64. http://dx.doi.org/10.4028/www.scientific.net/ssp.99-100.161.

Full text
Abstract:
A novel approach to load a hydrophilic bovine serum albumin (BSA) into the drug carriers was proposed in terms of thermosensitive dual-shell structures which were fabricated with poly(N-isopropylacrylamide), poly(lactide) and Au nanoparticles. Spherically well-defined dualshell structures were constructed by a modified-double-emulsion method (MDEM). The lower critical solubility temperature of the structures was shifted to 36.4 °C which was confirmed by UVVis spectroscopy.
APA, Harvard, Vancouver, ISO, and other styles
11

Li, Zong, Wenqiang Yan, Fengyuan Zhao, et al. "Regional specific tunable meniscus decellularized extracellular matrix (MdECM) reinforced bioink promotes anistropic meniscus regeneration." Chemical Engineering Journal 473 (October 2023): 145209. http://dx.doi.org/10.1016/j.cej.2023.145209.

Full text
APA, Harvard, Vancouver, ISO, and other styles
12

Santos, Georgianna Silva dos, and Maria de Fátima Alves de Oliveira. "Estratégias de ensino voltadas para educação alimentar: um artigo de revisão." Debates em Educação 13, no. 31 (2021): 621. http://dx.doi.org/10.28998/2175-6600.2021v13n31p621-647.

Full text
Abstract:
<p>Ações voltadas para a educação alimentar e incentivo à prática de atividades físicas, vem sendo discutido com frequência no Ensino de Ciências e nas políticas relacionadas a saúde pública, devido aos altos percentuais de sobrepeso e obesidade no Brasil. Neste sentido, o ambiente escolar é considerado como local propício para desenvolver ações de Educação Alimentar e Nutricional (EAN), visto que o aluno passa um bom tempo nesse espaço. Diante destes aspectos, traçamos como objetivo deste estudo analisar artigos, dissertações e teses no período de 2013 a 2019, disponíveis na base de dad
APA, Harvard, Vancouver, ISO, and other styles
13

Ruoqiang, Feng, Zhong Yuting, Wang Sini, and Chen Gang. "Research on single-layer grid structures considering joint connection failure based on MDEM." Journal of Constructional Steel Research 198 (November 2022): 107566. http://dx.doi.org/10.1016/j.jcsr.2022.107566.

Full text
APA, Harvard, Vancouver, ISO, and other styles
14

Sugimura, Yoko, Makoto Kinoshita, Kei Fukada, Kimiko Inoue, Harutoshi Fujimura, and Takanori Hazama. "An adult-onset multiphasic disseminated encephalomyelitis (MDEM) presenting favorable response to steroid therapy." Rinsho Shinkeigaku 56, no. 12 (2016): 846–51. http://dx.doi.org/10.5692/clinicalneurol.cn-000902.

Full text
APA, Harvard, Vancouver, ISO, and other styles
15

Azumagawa, Kohji, Shohei Nomura, Yasushi Shigeri, et al. "Post-vaccination MDEM associated with MOG antibody in a subclinical Chlamydia infected boy." Brain and Development 38, no. 7 (2016): 690–93. http://dx.doi.org/10.1016/j.braindev.2016.02.004.

Full text
APA, Harvard, Vancouver, ISO, and other styles
16

Poma Gutiérrez, Adolfo Guillermo, René Antonio Hinojosa Benavides, and Edgar Carlos Quispe Peña. "Efecto de raza, momento del día y características del pelo sobre la frecuencia cardiaca y respiratoria, y temperatura rectal y de piel en vacunos en zona de confort." Revista de Investigaciones Veterinarias del Perú 33, no. 4 (2022): e21804. http://dx.doi.org/10.15381/rivep.v33i4.21804.

Full text
Abstract:
El estudio tuvo como objetivo evaluar el efecto de la raza, momento del día y media de la densidad de pelos (MDenP) sobre la frecuencia cardiaca (FC), frecuencia respiratoria (FR), temperatura de piel (T°P), temperatura rectal (T°R) y diferencia T°R- T°P. Se trabajó con 10 vaquillas (4 Holstein y 6 criollas) entre 14 y 18 meses de edad, criadas al pastoreo y con temperatura ambiental (T°A) promedio de 17.6 °C y humedad relativa (H°R) promedio de 60.5%. Para el monitoreo de la FC, FR y T°P se utilizó un monitor de signos vitales llevable. Las mediciones se hicieron en la mañana, tarde y noche.
APA, Harvard, Vancouver, ISO, and other styles
17

Alassi, Haitham, and Rune Holt. "Modeling Fracturing in Rock Using a Modified Discrete Element Method with Plasticity." Key Engineering Materials 452-453 (November 2010): 861–64. http://dx.doi.org/10.4028/www.scientific.net/kem.452-453.861.

Full text
Abstract:
In this contribution we present more developments in the modified discrete element approach (MDEM) which was proposed to model fractures propagation in reservoir rock during production and fluid injection. The new development in this paper includes adding plasticity which allows the material to go into plastic deformation before initiating fractures. Several numerical tests are performed which mimic the real lab tests usually perform on rock samples, this includes direct tension test with initial crack to model crack propagation, and several biaxial compression tests to model the development o
APA, Harvard, Vancouver, ISO, and other styles
18

Banerjee, Asish, and Meenakshi Mitra. "Prognostic relevance of persistence of myelin oligodendrocyte glycoprotein antibody in pediatric acute disseminated encephalomyelitis." Asian Journal of Medical Sciences 13, no. 3 (2022): 59–64. http://dx.doi.org/10.3126/ajms.v13i3.41220.

Full text
Abstract:
Background: Myelin oligodendrocyte glycoprotein (MOG) antibody plays a significant role in demyelination in pediatric acute disseminated encephalomyelitis (ADEM). Aims and Objectives: To assess the prognostic relevance of persistence of MOG antibody in pediatric ADEM. Materials and Methods: A prospective observational study was conducted over a period of 3 years. Data were collected from Department of Pediatrics of a tertiary care hospital in Durgapur. Neurological examination findings, magnetic resonance imaging brain and spinal cord, electroencephalogram findings, and MOG antibody titer were
APA, Harvard, Vancouver, ISO, and other styles
19

Jockusch, Julia, Siri Nitschke, Werner Hopfenmüller, Oliver Schierz, Sebastian Hahnel, and Ina Nitschke. "Impact of an Oral Hygiene Intervention in People with and without Dementia on Oral Health Parameters—Results from the Oral Health, Bite Force, and Dementia (OrBiD) Pilot Study." Journal of Clinical Medicine 11, no. 5 (2022): 1356. http://dx.doi.org/10.3390/jcm11051356.

Full text
Abstract:
This study aimed to assess the influence of an oral hygiene intervention on oral health, depending on the degree of dementia. A clinical evaluation of oral health parameters (index of decayed, missing, and filled teeth (DMFT-index), periodontal screening index (PSI), oral hygiene index (OHI), and bleeding on probing (BOP)) was performed in 120 subjects assigned to five groups, based on the mini mental state examination (MMSE) at baseline and after 12 months. Each MMSE group (no dementia (noDem, MMSE 28–30), mild cognitive impairment (mCI, MMSE 25–27), mild dementia (mDem, MMSE 18–24), moderate
APA, Harvard, Vancouver, ISO, and other styles
20

Ching, BH, AR Mohamed, TB Khoo, and HIHM Ismail. "Multiphasic disseminated encephalomyelitis followed by optic neuritis in a child with gluten sensitivity." Multiple Sclerosis Journal 21, no. 9 (2015): 1209–11. http://dx.doi.org/10.1177/1352458515593404.

Full text
Abstract:
Multiphasic disseminated encephalomyelitis (MDEM) followed by optic neuritis (ON) has been described as a new entity in recent years. Gluten encephalopathy has also been recognized as a neurological manifestation of celiac disease. Accurate diagnosis of both is important due to the therapeutic implications. We report a girl presenting with recurrent encephalopathic polyfocal demyelinating episodes followed by optic neuritis, and a clinical history suggestive of gluten sensitivity. She had persistently high ESR, neutrophilia, and tested positive for anti-MOG (myelin oligodendrocyte glycoprotein
APA, Harvard, Vancouver, ISO, and other styles
21

Hacohen, Yael, Kshitij Mankad, W. K. Chong, et al. "Diagnostic algorithm for relapsing acquired demyelinating syndromes in children." Neurology 89, no. 3 (2017): 269–78. http://dx.doi.org/10.1212/wnl.0000000000004117.

Full text
Abstract:
Objective:To establish whether children with relapsing acquired demyelinating syndromes (RDS) and myelin oligodendrocyte glycoprotein antibodies (MOG-Ab) show distinctive clinical and radiologic features and to generate a diagnostic algorithm for the main RDS for clinical use.Methods:A panel reviewed the clinical characteristics, MOG-Ab and aquaporin-4 (AQP4) Ab, intrathecal oligoclonal bands, and Epstein-Barr virus serology results of 110 children with RDS. A neuroradiologist blinded to the diagnosis scored the MRI scans. Clinical, radiologic, and serologic tests results were compared.Results
APA, Harvard, Vancouver, ISO, and other styles
22

Nasim, Fathima N., Mohamed Z. F. Fasrina, Sunil B. Bowattage, Wickramasooriyage K. Kularatne, and Vipuli J. Kobbegala. "Acute hemorrhagic leukoencephalitis in a young female with excellent response to corticosteroids." Ceylon Medical Journal 68, no. 1 (2023): 29–35. http://dx.doi.org/10.4038/cmj.v68i1.9677.

Full text
Abstract:
Background: Acute hemorrhagic leukoencephalitis (AHLE) is a rare fulminant entity of acute disseminated leukoencephalitis (ADEM) that has a rapidly progressive polysymptomatology corresponding to areas of brain affected. It’s characterized by rapid cognitive decline, coma or even rapid death. It is postulated to be a post infective immune mediated monophasic demyelinating disease. Diagnosis is clinical supported by CSF and MRI findings. It is challenging to differentiate the disease from MDEM (multiphasic demyelinating encephalomyelitis) and multiple sclerosis during the initial presentation.C
APA, Harvard, Vancouver, ISO, and other styles
23

Gheibi, Sohrab, Nicolaine Agofack, and Sigbjørn Sangesland. "Modified discrete element method (MDEM) as a numerical tool for cement sheath integrity in wells." Journal of Petroleum Science and Engineering 196 (January 2021): 107720. http://dx.doi.org/10.1016/j.petrol.2020.107720.

Full text
APA, Harvard, Vancouver, ISO, and other styles
24

Wang, Chi-Kuei, and Nadeem Fareed. "Mapping Drainage Structures Using Airborne Laser Scanning by Incorporating Road Centerline Information." Remote Sensing 13, no. 3 (2021): 463. http://dx.doi.org/10.3390/rs13030463.

Full text
Abstract:
Wide-area drainage structure (DS) mapping is of great concern, as many DSs are reaching the end of their design life and information on their location is usually absent. Recently, airborne laser scanning (ALS) has been proven useful for DS mapping through manual methods using ALS-derived digital elevation models (DEMs) and hillshade images. However, manual methods are slow and labor-intensive. To overcome these limitations, this paper proposes an automated DS mapping algorithm (DSMA) using classified ALS point clouds and road centerline information. The DSMA begins with removing ALS ground poi
APA, Harvard, Vancouver, ISO, and other styles
25

Hennes, Eva-Maria, Matthias Baumann, Christian Lechner, and Kevin Rostásy. "MOG Spectrum Disorders and Role of MOG-Antibodies in Clinical Practice." Neuropediatrics 49, no. 01 (2017): 003–11. http://dx.doi.org/10.1055/s-0037-1604404.

Full text
Abstract:
AbstractMyelin oligodendrocyte glycoprotein (MOG) antibodies (abs) are present in one third of all children with an acute demyelinating syndrome (ADS). MOG-abs can be found in acute disseminated encephalomyelitis (ADEM), transverse myelitis, isolated optic neuritis (ON), or recurrent demyelinating diseases, such as multiphasic neuromyelitis optica spectrum disorders (NMOSD) without aquaporin-4 (AQP4) abs or multiphasic ADEM (MDEM), but rarely in children who subsequently develop multiple sclerosis (MS). The presence of MOG-abs is age dependent with the highest seropositivity rates found in you
APA, Harvard, Vancouver, ISO, and other styles
26

Takai, Yoshiki, Tatsuro Misu, Kimihiko Kaneko, et al. "Myelin oligodendrocyte glycoprotein antibody-associated disease: an immunopathological study." Brain 143, no. 5 (2020): 1431–46. http://dx.doi.org/10.1093/brain/awaa102.

Full text
Abstract:
Abstract Conformation-sensitive antibodies against myelin oligodendrocyte glycoprotein (MOG) are detectable in patients with optic neuritis, myelitis, opticomyelitis, acute or multiphasic disseminated encephalomyelitis (ADEM/MDEM) and brainstem/cerebral cortical encephalitis, but are rarely detected in patients with prototypic multiple sclerosis. So far, there has been no systematic study on the pathological relationship between demyelinating lesions and cellular/humoral immunity in MOG antibody-associated disease. Furthermore, it is unclear whether the pathomechanisms of MOG antibody-mediated
APA, Harvard, Vancouver, ISO, and other styles
27

Bruyneel, E. A., M. De Mets, C. H. Dragonetti, R. J. Hooghe, S. Di Virgilio, and M. M. Mareel. "Effect of glycosylation inhibitors on N-glycosylpeptides and on invasion of malignant mouse MO4 cells in vitro." Journal of Cell Science 95, no. 2 (1990): 279–86. http://dx.doi.org/10.1242/jcs.95.2.279.

Full text
Abstract:
Cell surface glycans are believed to play a role in tumour invasion and metastasis. Yet, we have previously shown that the inhibitors of N-linked glycan processing swainsonine (SW) and 1-deoxynojirimycin (dNM) did not prevent invasion of chick heart fragments by MO4 murine fibrosarcoma cells in organ culture. We now present biochemical evidence that these and other inhibitors of processing were indeed effective in remodeling glycans, including those expressed at the cell surface. After metabolic labeling with tritiated mannose or fucose, glycosylpeptides were obtained by Pronase treatment of m
APA, Harvard, Vancouver, ISO, and other styles
28

Mohamed, Yasien. "Islamization of Knowledge." American Journal of Islam and Society 11, no. 2 (1994): 283–94. http://dx.doi.org/10.35632/ajis.v11i2.2439.

Full text
Abstract:
The Islamization of knowledge, as envisioned by al Faruqi, is acritical, revivalistic response to intellectual modernity.' Its objective is atimeless but it can only be realized by challenging it and engagingMuslim scholars in debate over it. By so doing, we are able to refine thework plan for Islamization. The following critique is therefore presentedin the hope that its suggestions will contribute toward an authenticIslamic tespotlse to intellectual modernity.Exposition of IslamizationFor al Faruqi (1982), the some of the crisis of Muslim society liesin the mdem-Islamic dichotomy of the curr
APA, Harvard, Vancouver, ISO, and other styles
29

Kesercioğlu, Muhammed Asım, Abdullah Feyzi Keles, Nedim Sözbir, and Yusuf Çay. "Havacılıkta Kullanılan Elektronik Podun Isıl Kontrolü." Academic Perspective Procedia 2, no. 3 (2019): 621–33. http://dx.doi.org/10.33793/acperpro.02.03.66.

Full text
Abstract:
Pod, havacılıkta farklı görevler için kullanılmak üzere içerisinde çeşitli faydalı yükler bulunduran kutudur. Bu faydalı yükler elektronik ekipmanlardan oluşurken; navigasyon, keşif, hedefleme, arazi gözetleme, kızılötesi görüş gibi görevlerde kullanılmak üzere pod içerisine yerleştirilir. Pod; ön, orta ve arka olmak üzere üç ana böl&amp
APA, Harvard, Vancouver, ISO, and other styles
30

Dudas, Balint, Daniel Toth, David Perahia, Arnaud B. Nicot, Erika Balog, and Maria A. Miteva. "Insights into the substrate binding mechanism of SULT1A1 through molecular dynamics with excited normal modes simulations." Scientific Reports 11, no. 1 (2021). http://dx.doi.org/10.1038/s41598-021-92480-w.

Full text
Abstract:
AbstractSulfotransferases (SULTs) are phase II drug-metabolizing enzymes catalyzing the sulfoconjugation from the co-factor 3′-phosphoadenosine 5′-phosphosulfate (PAPS) to a substrate. It has been previously suggested that a considerable shift of SULT structure caused by PAPS binding could control the capability of SULT to bind large substrates. We employed molecular dynamics (MD) simulations and the recently developed approach of MD with excited normal modes (MDeNM) to elucidate molecular mechanisms guiding the recognition of diverse substrates and inhibitors by SULT1A1. MDeNM allowed explori
APA, Harvard, Vancouver, ISO, and other styles
31

Fagnen, Charline, Ludovic Bannwarth, Dania Zuniga, et al. "Unexpected Gating Behaviour of an Engineered Potassium Channel Kir." Frontiers in Molecular Biosciences 8 (June 10, 2021). http://dx.doi.org/10.3389/fmolb.2021.691901.

Full text
Abstract:
In this study, we investigated the dynamics and functional characteristics of the KirBac3.1 S129R, a mutated bacterial potassium channel for which the inner pore-lining helix (TM2) was engineered so that the bundle crossing is trapped in an open conformation. The structure of this channel has been previously determined at high atomic resolution. We explored the dynamical characteristics of this open state channel using an in silico method MDeNM that combines molecular dynamics simulations and normal modes. We captured the global and local motions at the mutation level and compared these data w
APA, Harvard, Vancouver, ISO, and other styles
32

Czigleczki, Janka, Pedro Tulio de Resende Lara, Balint Dudas, et al. "Small GTPase Ran: Depicting the nucleotide-specific conformational landscape of the functionally important C-terminus." Frontiers in Molecular Biosciences 10 (January 16, 2023). http://dx.doi.org/10.3389/fmolb.2023.1111574.

Full text
Abstract:
The small GTPase Ran is the main regulator of the nucleo-cytoplasmic import and export through the nuclear pore complex. It functions as a molecular switch cycling between the GDP-bound inactive and GTP-bound active state. It consists of a globular (G) domain and a C-terminal region, which is bound to the G-domain in the inactive, GDP-bound states. Crystal structures of the GTP-bound active form complexed with Ran binding proteins (RanBP) show that the C-terminus undergoes a large conformational change, embracing Ran binding domains (RanBD). Whereas in the crystal structures of macromolecular
APA, Harvard, Vancouver, ISO, and other styles
33

Kaynak, Burak T., James M. Krieger, Balint Dudas, et al. "Sampling of Protein Conformational Space Using Hybrid Simulations: A Critical Assessment of Recent Methods." Frontiers in Molecular Biosciences 9 (February 4, 2022). http://dx.doi.org/10.3389/fmolb.2022.832847.

Full text
Abstract:
Recent years have seen several hybrid simulation methods for exploring the conformational space of proteins and their complexes or assemblies. These methods often combine fast analytical approaches with computationally expensive full atomic molecular dynamics (MD) simulations with the goal of rapidly sampling large and cooperative conformational changes at full atomic resolution. We present here a systematic comparison of the utility and limits of four such hybrid methods that have been introduced in recent years: MD with excited normal modes (MDeNM), collective modes-driven MD (CoMD), and ela
APA, Harvard, Vancouver, ISO, and other styles
34

Xie, Yufang, Lijun Gao, and Suo Yang. "Input-to-state stability of impulsive switched systems under mode-dependent event-triggered impulsive control." Transactions of the Institute of Measurement and Control, May 21, 2024. http://dx.doi.org/10.1177/01423312241248489.

Full text
Abstract:
This paper aims to investigate input-to-state stability (ISS) of nonlinear impulsive switched systems under mode-dependent event-triggered impulsive control (MDETIC) method. A novel mode-dependent event-triggered mechanism (MDETM) is devised, where triggering impulsive instants are determined by some predesigned event conditions. Different from existing MDETM, there are two types of impulsive behavior involved, including the impulsive behavior of system itself and event-triggered one. The novel MDETM not only reduces communication cost and energy consumption but also excludes “Zeno behavior.”
APA, Harvard, Vancouver, ISO, and other styles
35

Zhang, Jinjie, Chengxiao Xu, Yingjie Zhang, et al. "Structural and compositional analysis of MOF-derived carbon nanomaterials for the oxygen reduction reaction." Chemical Communications, 2024. http://dx.doi.org/10.1039/d3cc05653h.

Full text
Abstract:
An in-depth analysis of the fundamental mechanism of MOF-derived carbon nanomaterials (MDCNM) for ORR promotion is presented through both the low-dimensional morphological structure and chemical composition.
APA, Harvard, Vancouver, ISO, and other styles
36

Luperchio, Teresa Romeo, Leandros Boukas, Li Zhang, et al. "Leveraging the Mendelian disorders of the epigenetic machinery to systematically map functional epigenetic variation." eLife 10 (August 31, 2021). http://dx.doi.org/10.7554/elife.65884.

Full text
Abstract:
Although each Mendelian Disorder of the Epigenetic Machinery (MDEM) has a different causative gene, there are shared disease manifestations. We hypothesize that this phenotypic convergence is a consequence of shared epigenetic alterations. To identify such shared alterations, we interrogate chromatin (ATAC-seq) and expression (RNA-seq) states in B cells from three MDEM mouse models (Kabuki [KS] type 1 and 2 and Rubinstein-Taybi type 1 [RT1] syndromes). We develop a new approach for the overlap analysis and find extensive overlap primarily localized in gene promoters. We show that disruption of
APA, Harvard, Vancouver, ISO, and other styles
37

Lyons, Naomi, Alexa Strasser, Bernard Beitz, et al. "Bodily Maps of Emotion in Major Depressive Disorder." Cognitive Therapy and Research, December 28, 2020. http://dx.doi.org/10.1007/s10608-020-10195-0.

Full text
Abstract:
Abstract Background Emotions play a central role in mental disorder and especially in depression. They are sensed in the body, and it has recently been shown in healthy participants that these sensations can be differentiated between emotions. The aim of the current study was to assess bodily sensations for basic emotions induced by emotion eliciting pictures in depression. Methods 30 healthy controls (HC), 30 individuals suffering from Major depressive disorder (MDD) without medication use (MDDnm) and 30 individuals with MDD with medication use (MDDm) were shown emotional and neutral pictures
APA, Harvard, Vancouver, ISO, and other styles
38

Acharya, Subhajit, and Biman Bagchi. "Rate theory of gas–liquid nucleation: Quest for the elusive quantitative accuracy." Journal of Chemical Physics 160, no. 17 (2024). http://dx.doi.org/10.1063/5.0202884.

Full text
Abstract:
The task of a first principles theoretical calculation of the rate of gas–liquid nucleation has remained largely incomplete despite the existence of reliable results from unbiased simulation studies at large supersaturation. Although the classical nucleation theory formulated by Becker–Doring–Zeldovich about a century ago provides an elegant, widely used picture of nucleation in a first-order phase transition, the theory finds difficulties in predicting the rate accurately, especially in the case of gas-to-liquid nucleation. Here, we use a multiple-order parameter description to construct the
APA, Harvard, Vancouver, ISO, and other styles
39

Sankhyan, Naveen, Amit Rawat, Sameer Vyas, et al. "Seroprevalence of MOG and AQP4 antibodies and outcomes in an Indian cohort of Pediatric Acquired Demyelinating Syndromes." Neuropediatrics, May 26, 2022. http://dx.doi.org/10.1055/a-1863-1862.

Full text
Abstract:
This study aimed to determine the seropositivity of myelin oligodendrocyte glycoprotein antibodies (MOG-Ab) and aquaporin-4 antibodies (AQP4-Ab) and outcomes in children with acquired demyelinating syndromes (ADS). Children (6months-15years) with suspected ADS were enrolled and tested for MOG-Ab and AQP4-Ab prospectively over 18 months at a tertiary-care hospital in North India. Children with proven non-immune mediated neurological disorders were enrolled as controls. Of 79 children with suspected ADS, 66 were enrolled. Among the enrolled children with ADS, ADEM (25) was the commonest first cl
APA, Harvard, Vancouver, ISO, and other styles
40

M. Anzidei. "The marine digital terrain model of the Panarea caldera (Aeolian Islands, Southern Italy)." Annals of Geophysics 41, no. 2 (1998). http://dx.doi.org/10.4401/ag-4328.

Full text
Abstract:
A Marine Digital Elevation Model (MDEM) of the still active volcanic area of Panarea caldera is presented in this paper. A fast and accurate survey was performed by means of the Differential Global Positioning System (DGPS) geodetic technique coupled with an echo-sounding gear and a real time navigation software. The instrumentation was installed on board of a low draught boat in order to collect data starting from the bathymeter of one meter. Planar positions and depths were obtained with average accuracies of 30 cm and 10 cm respectively providing a 3D map of the seafloor useful for geomorph
APA, Harvard, Vancouver, ISO, and other styles
41

Zhang, Ziyu, Xinsong Yang, Ju H. Park, and Zhilu Xu. "Observer‐based dual event‐triggered control for non‐weighted L2$$ {\mathcal{L}}_2 $$‐gain of switched linear systems." Asian Journal of Control, March 3, 2024. http://dx.doi.org/10.1002/asjc.3351.

Full text
Abstract:
AbstractAs everyone knows, strict mode‐dependent event‐triggered mechanism (MDETM) is rarely studied for switched systems due to the difficulty in settling down the relationship between the dwell time (DT) and triggered intervals. This problem is satisfactorily solved by considering the exponential stabilization via observer‐based dual MDETMs in switched linear systems. The dual MDETMs on the sensor‐controller (S‐C) channel and controller‐actuator (C‐A) channel are designed respectively according to mode‐dependent average dwell time (MDADT). The MDETMs on the C‐A channel are generated based on
APA, Harvard, Vancouver, ISO, and other styles
42

Bouman, Arianne, Joyce M. Geelen, Joost Kummeling, et al. "Growth, body composition, and endocrine‐metabolic profiles of individuals with Kleefstra syndrome provide directions for clinical management and translational studies." American Journal of Medical Genetics Part A, December 29, 2023. http://dx.doi.org/10.1002/ajmg.a.63472.

Full text
Abstract:
AbstractMendelian neurodevelopmental disorders caused by variants in genes encoding chromatin modification can be categorized as Mendelian disorders of the epigenetic machinery (MDEMs). These disorders have significant overlap in molecular pathways and phenotypes including intellectual disability, short stature, and obesity. Among the MDEMs is Kleefstra syndrome (KLFS), which is caused by haploinsufficiency of EHMT1. Preclinical studies have identified metabolic dysregulation and obesity in KLFS models, but proper clinical translation lacks. In this study, we aim to delineate growth, body comp
APA, Harvard, Vancouver, ISO, and other styles
43

Jockusch, Julia, Sebastian Hahnel, and Ina Nitschke. "Use of handgrip strength measurement as an alternative for assessing chewing function in people with dementia." BMC Geriatrics 22, no. 1 (2022). http://dx.doi.org/10.1186/s12877-022-03452-2.

Full text
Abstract:
Abstract Background Chewing ability and handgrip strength can be independent explanatory factors of physical fitness. The usability of measurement procedures for assessing chewing function in people with dementia seems to be limited. This study aimed to show an association between handgrip strength and chewing function to enable the use of handgrip strength measurement as an alternative for determining chewing parameters in people with dementia. Methods The data analysed here are part of the OrBiD (Oral Health, Bite Force and Dementia) pilot study. A total of 120 participants were assigned to
APA, Harvard, Vancouver, ISO, and other styles
44

Li, Shun, Huijuan Li, Dihua Liu, et al. "Identification of novel mendelian disorders of the epigenetic machinery (MDEMs) associated functional mutations and neurodevelopmental disorders." QJM: An International Journal of Medicine, January 10, 2023. http://dx.doi.org/10.1093/qjmed/hcad005.

Full text
Abstract:
Summery Background Mendelian disorders of the epigenetic machinery (MDEMs) are a newly identified group of neurodevelopmental disorders (NDDs) and multiple congenital anoMalies caused by mutations in genes encoding components of the epigenetic machinery. Many studies have shown that MDEM-associated mutations may disrupt the balance between chromatin states and trigger dysplasia. Aim To help eight Chinese families with neurodevelopmental disorders acquire a definitive diagnosis. Methods In this study, we used whole-exome sequencing (WES) to diagnose eight unrelated Chinese families with NDDs. W
APA, Harvard, Vancouver, ISO, and other styles
45

Hor, Jyh Yung, and Kazuo Fujihara. "Epidemiology of myelin oligodendrocyte glycoprotein antibody-associated disease: a review of prevalence and incidence worldwide." Frontiers in Neurology 14 (September 15, 2023). http://dx.doi.org/10.3389/fneur.2023.1260358.

Full text
Abstract:
Myelin oligodendrocyte glycoprotein (MOG) antibody-associated disease (MOGAD) is an inflammatory demyelinating disease of the central nervous system (CNS) with the presence of conformation-sensitive antibodies against MOG. The spectrum of MOGAD includes monophasic/relapsing optic neuritis, myelitis, neuromyelitis optica spectrum disorder (NMOSD) phenotype without aquaporin 4 (AQP4) antibodies, acute/multiphasic demyelinating encephalomyelitis (ADEM/MDEM)-like presentation, and brainstem and cerebral cortical encephalitis. There is no apparent female preponderance in MOGAD, and MOGAD can onset
APA, Harvard, Vancouver, ISO, and other styles
46

Kalinousky, Allison J., Tyler Rapp, Hadia Hijazi, Jennifer Johnson, Hans Tomas Bjornsson, and Jacqueline R. Harris. "Neurobehavioral phenotype of Kabuki syndrome: Anxiety is a common feature." Frontiers in Genetics 13 (October 6, 2022). http://dx.doi.org/10.3389/fgene.2022.1007046.

Full text
Abstract:
Kabuki syndrome (KS) is a Mendelian Disorder of the Epigenetic Machinery (MDEM) caused by loss of function variants in either of two genes involved in the regulation of histone methylation, KMT2D (34–76%) or KDM6A (9–13%). Previously, representative neurobehavioral deficits of KS were recapitulated in a mouse model, emphasizing the role of KMT2D in brain development, specifically in ongoing hippocampal neurogenesis in the granule cell layer of the dentate gyrus. Interestingly, anxiety, a phenotype that has a known association with decreased hippocampal neurogenesis, has been anecdotally report
APA, Harvard, Vancouver, ISO, and other styles
We offer discounts on all premium plans for authors whose works are included in thematic literature selections. Contact us to get a unique promo code!

To the bibliography