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1

Davidson, Alexander F. "Elucidating the mechanism of localised mDNA translation during Drosophila oogenesis." Thesis, University of Oxford, 2015. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.711933.

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2

Costa, José Luiz da. "Determinação de 3,4-metilenodioximetanfetamina (MDMA - Ecstasy), 3,4-metilenodioxietilanfetamina (MDEA - Eve) e 3,4-metilenodioxianfetamina (MDA) em fluidos biológicos por cromatografia líquida de alta eficiência: aspecto forense." Universidade de São Paulo, 2004. http://www.teses.usp.br/teses/disponiveis/9/9141/tde-11032005-190039/.

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Em todo o mundo é crescente o uso drogas de abuso sintéticas conhecidas com designer drugs. Os principais representantes desta classe são o Ecstasy ou 3,4-metilenodioximetanfetamina (MDMA) e o Eve ou 3,4-metilenodioxietilanfetamina (MDEA), substâncias com efeitos estimulantes e alucinógenos. No Brasil é crescente sua divulgação pela mídia e o uso recreacional tem sido constatado em vários pacientes que buscam tratamento nas clínicas para dependentes. O presente trabalho constitui validação de metodologia analítica para o diagnóstico laboratorial do uso de MDMA, MDEA e seu produto de biotransfo
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3

Cormick, Justin. "Isotope ratio analysis of 3,4-methylenedioxyamphetamine (MDA) and 3,4-methylenedioxymethylamphetamine (MDMA) synthesised from helional." Thesis, Griffith University, 2022. http://hdl.handle.net/10072/415810.

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Illicit drug profiling describes the applications of chemical or physical drug profiles to areas such as law enforcement and legislation. Stable isotope analysis by stable isotope ratio mass spectrometry (IRMS) has become a useful tool for illicit drug profiling purposes. The following research was focused on the illicit drug profiling of 3,4-methylenedioxyamphetamine (MDA) and 3,4-methylenedioxmethylamphetamine (MDMA) by IRMS. Following an extensive literature review, it was surmised that the illicit drug profiling of MDMA (and a lesser extent MDA) by IRMS was complicated. Previous research s
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4

Wieliczko, Monika J. "Psychological effects of MDMA." Thesis, Canterbury Christ Church University, 2016. http://create.canterbury.ac.uk/14928/.

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Zinberg's Interaction Model implies that the content of a drug-induced experience is a function of the pharmacological properties of the drug, the set (the user’s characteristics e.g. motivation and personality), and the setting (the physical and social context). The current research investigated the function of the set and setting and their role in shaping the psychological effects of 3,4-methylenedioxmethamphetamine (MDMA), as well as their role in reducing the risk of drug abuse. An online survey was distributed among adult MDMA polydrug users (n = 158) and MDMA-naïve controls (alcohol, nic
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5

Giesen, Ralf. "Mathematische Modellierung des MDEA-Absorptionsprozesses." [S.l.] : [s.n.], 2004. http://deposit.ddb.de/cgi-bin/dokserv?idn=973450738.

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6

Anneken, John H. "Glutamate and MDMA Neurobehavioral Toxicity." University of Cincinnati / OhioLINK, 2012. http://rave.ohiolink.edu/etdc/view?acc_num=ucin1353342344.

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7

Bósio, Graziela Costa. "Contribuição individual dos enatiômeros isolados da 3,4-metilenodioximetanfetamina (MDMA) comparativamente com a mistura racêmica no estresse oxidativo hepático, renal e estriatal de ratos." Universidade de São Paulo, 2012. http://www.teses.usp.br/teses/disponiveis/9/9141/tde-19062013-160903/.

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A 3,4-metilenodioximetanfetamina (MDMA, ecstasy), derivada da anfetamina, é uma droga largamente utilizada para fins recreacionais devido à sensação de euforia, energia e desejo de socialização. Apesar de ter a reputação de ser uma droga segura, um número crescente de relatos clínicos e estudos experimentais indica que a MDMA pode produzir toxicidade no SNC, rim, fígado e coração. Embora esteja contida nos comprimidos de ecstasy como racemato (uma mistura de 50% de seus enantiômeros), sua biotransformação é enantioseletiva; em ratos, o enantiômero R é biotransformado mais rapidamente que o S.
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8

Chaves, Rafael Alves. "Aspectos e MDA." Florianópolis, SC, 2004. http://repositorio.ufsc.br/xmlui/handle/123456789/87201.

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Dissertação (mestrado) - Universidade Federal de Santa Catarina, Centro Tecnológico. Programa de Pós-Graduação em Ciência da Computação.<br>Made available in DSpace on 2012-10-21T16:17:57Z (GMT). No. of bitstreams: 1 235612.pdf: 591706 bytes, checksum: 504520bc0ea1832a0e9fadc7b3c69fed (MD5)<br>As principais contribuições deste trabalho consistem em analisar o potencial do uso conjunto das abordagens MDA e orientação a aspectos, e propor extensões à UML para comportar a criação de modelos executáveis usando o paradigma de aspectos.
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9

Chakma, Amitabha. "Studies on DEA and MDEA degradation." Thesis, University of British Columbia, 1987. http://hdl.handle.net/2429/26971.

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Aqueous diethanolamine ("DEA") is widely used for the removal of acid gases such as C0₂ and H₂S while aqueous methyl diethanoamine("MDEA") is primarily used for the selective removal of H₂S in the presence of C0₂ from light hydrocarbon gases. In addition to normal absorption and desorption reactions, some side reactions occur between C0₂, DEA and MDEA resulting in the formation of degradation compounds. Degradation not only represents a loss of valuable solvent, but may also lead to operational problems such as corrosion, foaming and fouling. C0₂ equilibrium solubility in aqueous MDEA solutio
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10

Christian, Michael. "Exploring MDMA and its therapeutic potential." Honors in the Major Thesis, University of Central Florida, 2012. http://digital.library.ucf.edu/cdm/ref/collection/ETH/id/672.

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The clinical application of MDMA has long been an issue of great interest for doctors, counselors, researchers, and users alike. Originally synthesized by a pharmaceutical company and subsequently tested on military personnel, the drug was then used by many clinicians and physicians prior to the DEA's strict regulation of the drug, which began in the mid 1980s (Mithoefer et al, 2010). The DEA has classified MDMA a "Schedule 1" drug, which means that it among the most controlled substances, a fact which has hindered the progress of research. For a detailed explanation of the DEA's scheduling of
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11

Bhide, Nirmal S. "Tolerance to MDMA-induced serotonergic neurotoxicity." University of Cincinnati / OhioLINK, 2010. http://rave.ohiolink.edu/etdc/view?acc_num=ucin1267719790.

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12

Palhol, Fabien. "Contribution à l'étude des saisies d'Ecstasy par spectrométrie de masse de rapports isotopiques : apport du rapport 15N/14N." Nantes, 2002. http://www.theses.fr/2002NANT2057.

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Illicit drugs have always been used by humans. With scientific progress, new drugs appear each year. At the present time, in France, Ecstasy is the most widespread illicit synthetic drug. The term Ecstasy generally refers to tablets containing 3,4-méthylendioxy-methamphetamine (MDMA). In order to struggle against traffics of drugs of abuse, many methods can be employed. In this study, 13C/12C and 15N/14N ratios of MDMA samples were measured by isotopic techniques, in particular by using a Gas chromatograph-combustion-isotope ratio mass spectrometer (GC-C-IRMS). The aim of such analyses was to
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13

Yubero, Lahoz Samanta 1985. "MDMA pharmacology in humans and serotonergic effects." Doctoral thesis, Universitat Pompeu Fabra, 2013. http://hdl.handle.net/10803/145481.

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3,4-methylenedioxymethamphetamine (MDMA, ecstasy) is one of the most abused recreational drugs in the world. It has been extensively reported that this drug inhibits its own metabolism by inhibiting a polymorphic liver enzyme, CYP2D6, which is responsible for the clearance of one quarter of drugs used in therapeutics. This phenomenon has important clinical implications, since MDMA users display a higher prevalence of psychopathology, particularly of mood disorders, compared to control population. Importantly, these psychiatric diseases are treated with drugs most of them substrate of thi
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Lebsanft, Heike Birgit. "MDMA ("Ecstasy") in Tiermodellen des Morbus Parkinson." [S.l.] : [s.n.], 2004. http://deposit.ddb.de/cgi-bin/dokserv?idn=972748601.

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15

ABLE, JESSICA ANN. "MDMA ADMINISTRATION AFFECTS COGNITION IN THE RAT." University of Cincinnati / OhioLINK, 2006. http://rave.ohiolink.edu/etdc/view?acc_num=ucin1147890602.

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16

BARBOSA, Paulo Eduardo e. Silva. "MDA-VERITAS: uma arquitetura MDA estendida para transformações de sistemas concorrentes preservadoras de semântica." Universidade Federal de Campina Grande, 2011. http://dspace.sti.ufcg.edu.br:8080/jspui/handle/riufcg/1764.

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Submitted by Johnny Rodrigues (johnnyrodrigues@ufcg.edu.br) on 2018-09-20T18:52:30Z No. of bitstreams: 1 PAULO EDUARDO E SILVA BARBOSA - TESE PPGCC 2011..pdf: 8460190 bytes, checksum: 711c8b40aaed80c81ec520880038d9b8 (MD5)<br>Made available in DSpace on 2018-09-20T18:52:30Z (GMT). No. of bitstreams: 1 PAULO EDUARDO E SILVA BARBOSA - TESE PPGCC 2011..pdf: 8460190 bytes, checksum: 711c8b40aaed80c81ec520880038d9b8 (MD5) Previous issue date: 2011-09-08<br>MDA é uma tendência de desenvolvimento de software que visa alterar o foco e os esforços dos modelos de desenvolvimento atuais. O método de im
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17

Turner, Alexandra. "What is the difference between Ecstasy and MDMA?" Thesis, Anglia Ruskin University, 2016. http://arro.anglia.ac.uk/701011/.

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In society there is a discrepancy that has developed in what the public understands about what Ecstasy is, in relation to the term ‘MDMA’. MDMA, the abbreviation for 3, 4-methylenedioxymethamphetamine, is the chemical constituent that has most commonly been associated with the street drug known as Ecstasy. Though the use of Ecstasy was reportedly on the decrease, a new product has emerged known as crystal or MDMA powder. This is alongside new competing compounds entering the market, most notably Mephedrone. The research examined explores the changing perception around what the terms Ecstasy an
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Turner, Alexandra. "What is the difference between Ecstasy and MDMA?" Thesis, Anglia Ruskin University, 2016. https://arro.anglia.ac.uk/id/eprint/701011/1/Alexandra_Turner_Thesis_03.03.2016.pdf.

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In society there is a discrepancy that has developed in what the public understands about what Ecstasy is, in relation to the term ‘MDMA’. MDMA, the abbreviation for 3, 4-methylenedioxymethamphetamine, is the chemical constituent that has most commonly been associated with the street drug known as Ecstasy. Though the use of Ecstasy was reportedly on the decrease, a new product has emerged known as crystal or MDMA powder. This is alongside new competing compounds entering the market, most notably Mephedrone. The research examined explores the changing perception around what the terms Ecstasy a
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19

Huff, Courtney L. M. S. "MDMA and Glutamate: Implications for Hippocampal GABAergic Neurotoxicity." University of Cincinnati / OhioLINK, 2016. http://rave.ohiolink.edu/etdc/view?acc_num=ucin1460444662.

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20

Fonsart, Julien. "Toxicité aiguë, métabolisme et pharmacocinétique de la 3,4-méthylènedioxyméthamphétamine (MDMA, ecstasy) : influence du sexe chez le rat Sprague-Dawley." Paris 5, 2008. http://www.theses.fr/2008PA05P651.

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La consommation de 3,4-méthylènedioxyméthamphétamine (MDMA, ecstasy), amphétamine synthétique provoquant une hyperthermie et un syndrome sérotoninergique mortels, s'est considérablement accrue. Les hommes semblent plus sensibles à sa toxicité aiguë et ses effets secondaires physiologiques que les femmes (sex-ratio de 4:1). Plusieurs études ont rapporté des constatations similaires chez le rongeur. La présenté étude montre une différence de DL50 marquée chez les rats mâles et femelles (18 contre 42,5 mg/kg), mais aussi d'effet hyperthermique (0,9°C) de la MDMA, tout en évaluant l'hypothèse d'un
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21

Ben, Hamida Sami. "Interactions entre MDMA et éthanol : effets comportementaux, physiologiques et pharmacologiques." Strasbourg, 2009. http://www.theses.fr/2009STRA6036.

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Des expériences réalisées dans notre laboratoire sur des rats mâles de la souche Long-Evans, ont montré que l’éthanol, administré en même temps que la 3,4- méthylènedioxymethamphétamine (MDMA ; ecstasy), atténue l'hyperthermie et potentialise les effets locomoteurs induits par cette drogue. Ce travail de thèse s’inscrit dans la continuité de ces observations. Ma démarche expérimentale a consisté en une étude fondamentale, dont l’objectif était de mieux comprendre les interactions pharmacocinétiques et pharmacodynamiques entre la MDMA et l’éthanol. Nous avons montré l’aspect unique de l’interac
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22

Soares, Inali Wisniewski. "PM-MDA: um método para o desenvolvimento de modelos de plataforma no contexto da MDA." Universidade Tecnológica Federal do Paraná, 2012. http://repositorio.utfpr.edu.br/jspui/handle/1/716.

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Esta tese propõe um método denominado PM-MDA para o desenvolvimento de Modelos de Plataforma (Platform Model - PM) no contexto da abordagem Model Driven Architecture (MDA). O método PM-MDA tem como foco o desenvolvimento de projetos de Software embarcado baseados em Sistemas Operacionais em Tempo Real (Real-Time Operating System - RTOS). Adicionalmente, este estudo define um perfil UML 2.0 para modelagem da aplicação e plataforma de software embarcado denominado Profile for modeling Application and Platform of Embedded Software (PROAPES) que é usado no método PM-MDA. Tal perfil define um conju
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23

Medina, Krista Lisdahl. "Ecstasy (MDMA) Exposure and Neuropsychological Functioning: A Polydrug Perspective." Cincinnati, Ohio : University of Cincinnati, 2005. http://www.ohiolink.edu/etd/view.cgi?acc%5Fnum=ucin1112218607.

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24

Orejarena, Maria Juliana. "Neurobiological mechanisms involved in MDMA-Seeking behaviour and relapse." Doctoral thesis, Universitat Pompeu Fabra, 2010. http://hdl.handle.net/10803/7229.

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(+) 3,4-metilendioximetanfetamina (MDMA), popularmente conocida como "éxtasis", es una droga susceptible de producir adicción en algunos individuos. Actualmente es consumida principalmente por adolescentes y jóvenes. Los particulares efectos psicoactivos inducidos por la MDMA, permiten distinguirlo de manera clara de otros psicoestimulantes o compuestos alucinógenos. Esta droga actúa principalmente activando el sistema dopaminérgico y serotonérgico en los circuitos neurales de placer. Sin embargo, los mecanismos neurobiológicos implicados en las propiedades adictivas de esta droga no han sido
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Kuypers, Kim Paula Colette. "Psychedelic bliss: memory and risk taking during MDMA intoxication." [Maastricht : Maastricht : Universiteit Maastricht ] ; University Library, Universiteit Maastricht [host], 2007. http://arno.unimaas.nl/show.cgi?fid=8303.

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Straiko, Megan M. W. "Consequences of ± 3,4-methylenedioxymethamphetamine (MDMA) administration in the rat." Cincinnati, Ohio : University of Cincinnati, 2006. http://www.ohiolink.edu/etd/view.cgi?acc%5Fnum=ucin1153777964.

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Thesis (Ph. D.)--University of Cincinnati, 2006.<br>Title from electronic thesis title page (viewed Sept. 11, 2007). Includes abstract. Keywords: MDMA; neurotoxicity; C-tau; sex behavior; nitric oxide. Includes bibliographical references.
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Rodsiri, Ratchanee. "MDMA : binge use and functional outcomes in the rat." Thesis, University of Nottingham, 2009. http://eprints.nottingham.ac.uk/13386/.

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3,4-Methylenedioxymethamphetamine (MDMA) use has increased dramatically and more intensive patterns of use such as binging have become common. This thesis pays particular attention to the translation of animal data to humans by examining low doses and binge type repeated regimen of MDMA in the rat. The functional effects especially acute and long-term effects on memory have been investigated together with the measurement of changes in 5-HT and dopamine to investigate the possible link of these neurotransmitters and the functional effects of MDMA. The acute effect of single low doses of MDMA on
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28

Easton, Neil. "3,4-Methylenedioxymethamphetamine (MDMA, Ecstacy) neurotoxicity : role of thioether adducts." Thesis, Nottingham Trent University, 2003. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.272853.

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Sharifimonfared, Ghazaleh. "Pathways through MDMA use : a qualitative life story study." Thesis, University of Hull, 2016. http://hydra.hull.ac.uk/resources/hull:15621.

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MDMA is a popular psychoactive drug that is highly associated with raves and clubbing culture. Consumers experience feelings of euphoria, joy, and confidence. Despite the considerable research on MDMA, non-problematic aspects of use remain under researched. The aim of this study was to understand MDMA use and pathways into and out of consumption. More specifically, the research examines the experience of ex-heavy MDMA users through their MDMA journeys. This qualitative study employed an online questionnaire inspired by the Life Story Approach. Participants were recruited using ethnographic res
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Wareing, M. "Working memory and executive deficits among MDMA (Ecstasy) users." Thesis, Edge Hill University, 2005. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.439660.

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31

Roberts, C. A. "Neurophysiological correlates of ecstasy/MDMA use on executive functioning." Thesis, Liverpool John Moores University, 2014. http://researchonline.ljmu.ac.uk/4524/.

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The purpose of this thesis was to assess the integrity of the serotonin system, by measuring the neurophysiological response to tasks that measure executive functions, and neuroendocrine function in ecstasy users and non-users. Each of the proposed executive functions outlined in Miyake et al.’s (2000) conceptual framework (inhibition, switching and updating) as well as the addition of access to semantic/long term memory made by Fisk and Sharp (2004), was assessed using behavioural tasks in combination with EEG and fNIRS. Behavioural performance between ecstasy users and various controls (poly
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Hatala, Elaine M. "Characteristics and Predictors of Ecstasy (MDMA) Use During College." Diss., Temple University Libraries, 2008. http://cdm16002.contentdm.oclc.org/cdm/ref/collection/p245801coll10/id/882.

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Public Health<br>Ph.D.<br>This cross-sectional investigation examined characteristics of ecstasy use during college and associations between ecstasy use during college and demographic factors, family functioning, mental health, and stage of change for ecstasy use. In addition a multivariate model was developed to predict characteristics of ecstasy use during college. An electronic survey was sent to all undergraduate students enrolled at a large urban university in the mid-Atlantic region of the United States during the spring of 2007. Demographic factors and characteristics of ecstasy use wer
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Gabay, Anthony Stuart. "An investigation of social cognition using psilocybin and MDMA." Thesis, King's College London (University of London), 2017. https://kclpure.kcl.ac.uk/portal/en/theses/an-investigation-of-social-cognition-using-psilocybin-and-mdma(dedc1c2c-5023-4cba-9994-6178214334f3).html.

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Impairments of social function are increasingly thought to be fundamental to the psychopathology of psychiatric disorders. Current treatments are not assessed against these social domains and the effects of medication are poorly understood. Furthermore, the neural mechanisms and psychopharmacology underlying these functions in the healthy population are poorly understood. This thesis addresses this knowledge gap. A meta-analysis of antipsychotic treatment effects on emotion processing in schizophrenia confirms the lack of efficacy of current treatments in treating these social deficits. Follow
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Gall, Dariusz, and Michał Molenda. "EDOC to EJB transformations within MDA." Thesis, Blekinge Tekniska Högskola, Avdelningen för programvarusystem, 2005. http://urn.kb.se/resolve?urn=urn:nbn:se:bth-4159.

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The Model Driven Architecture is a proposition of the framework of software development process where main accent is put on system models, i.e. platform independent and platform dependent models, and transformations between them. Applying the MDA is related with preparation of these two types of assets. In the thesis, the EDOC and the EJB platform are considered as an examples of platform-independent and platform dependent models. In order to complete this picture, additionally transformations between these two models are required. The authors focus in the thesis on transformations. In particu
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Škultinas, Tomas. "MDA panaudojimo programinės įrangos kūrimui tyrimas." Master's thesis, Lithuanian Academic Libraries Network (LABT), 2005. http://vddb.library.lt/obj/LT-eLABa-0001:E.02~2005~D_20050524_163850-89727.

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IT industry all time is looking for ways to improve software development productivity as well as the quality and longevity of the software that it creates. OMG announced Model Driven Architecture as its strategic direction. It is software development methodology that provides new viewpoint in software development process. The modeling of problem domain and model transformation are key elements of MDA architecture and they are analyzed in this work using OMG specifications and other resources. The purpose of this work is to evaluate benefits of MDA framework in software development process. The
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Michl, Zbyněk. "T-Mobile MDA II v Linuxu." Master's thesis, Vysoké učení technické v Brně. Fakulta informačních technologií, 2009. http://www.nusl.cz/ntk/nusl-236630.

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MSc. thesis deals with mobile digital assistant T-Mobile MDA II running Linux operating system. The first part presents device identification and parameters' specification of the MDA II. The second part focuses on selection of GNU distribution with Linux bootloader and Linux kernel support comparison. The subject of the last part is MDA II component code implementation and its merging into Linux kernel.
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Becker, Steffen. "Coupled model transformations for QoS enabled component-based software design." Karlsruhe Univ.-Verl. Karlsruhe, 2008. http://d-nb.info/990667650/04.

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Almeida, Stella Pereira de. "Primeiro perfil do usuário de "êxtase" (MDMA) em São Paulo." Universidade de São Paulo, 2000. http://www.teses.usp.br/teses/disponiveis/47/47132/tde-17012006-152155/.

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O presente estudo teve como objetivo identificar os padrões de uso de "êxtase" na cidade de São Paulo. Os usuários foram recrutados através da técnica de amostragem snowball, também utilizada para o recrutamento do grupo controle, composto de indivíduos com estilo de vida semelhante aos primeiros mas que nunca haviam experimentado "êxtase" (não usuários). Usuários (52) e não usuários (52) foram entrevistados quanto às características sócio-demográficas e quanto ao uso de drogas psicotrópicas; usuários também responderam questões sobre circunstâncias de uso e efeitos do "êxtase". Através da Esc
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Agostinho, Túlio de Castro. "Análise voltamétrica de 3,4-metilenodioximetanfetamina." Universidade de São Paulo, 2013. http://www.teses.usp.br/teses/disponiveis/59/59138/tde-12122012-102825/.

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O propósito do estudo realizado foi de investigar o comportamento voltamétrico da 3,4-metilenodioximetanfetamina (MDMA), substância psicoativa do ecstasy, uma droga que tem se tornado cada vez mais popular entre os usuários de drogas. Empregou-se o uso da técnica de cromatografia líquida de alta eficiência, para isolar a substância a partir de amostras de ecstasy obtidas em parceria com a Polícia Científica de Ribeirão Preto, bem como a técnica de espectrometria de massas, para confirmar a presença da MDMA nas mesmas. Os estudos voltamétricos foram realizados utilizando-se um sistema de três
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Wagenborg, David. "MDA development by design or by policy." Thesis, Monterey, Calif. : Naval Postgraduate School, 2008. http://bosun.nps.edu/uhtbin/hyperion-image.exe/08Mar%5FWagenborg.pdf.

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Thesis (M.S. in Information Systems and Operations)--Naval Postgraduate School, March 2008.<br>Thesis Advisor(s): Gallup, Shelley. "March 2008." Description based on title screen as viewed on May 16, 2008. Includes bibliographical references (p. 59-60). Also available in print.
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Peat, Jonathan David. "The human Mda-7 / IL-24 gene." Thesis, University of Glasgow, 2003. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.398630.

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Beveridge, Thomas James Ramsey. "An investigation into the neuronal activity induced by direct and indirect 5-HTâ‚‚ agonists as indicated by Arc mRNA." Thesis, De Montfort University, 2003. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.271936.

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Theodoro, Júnior Marcelo Brandão. "MDWA : Uma abordagem guiada por modelos para desenvolvimento de software Web." Universidade Federal de São Carlos, 2012. https://repositorio.ufscar.br/handle/ufscar/515.

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Made available in DSpace on 2016-06-02T19:06:01Z (GMT). No. of bitstreams: 1 4801.pdf: 4117819 bytes, checksum: b4df67024157ee1a2c79256315a97e7d (MD5) Previous issue date: 2012-11-13<br>Universidade Federal de Sao Carlos<br>Software development techniques continually evolve in order to improve development and maintenance processes in addition to lower costs and higher quality. The goal of MDD is to reduce the semantic distance between a problem and its solution specification. Therefore MDD focuses on high-level abstraction modeling and successive model transformations, until finally, generat
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44

Fallon, John Kevin. "Stereospecific analysis and enantiomeric disposition of 3,4-methylenedioxymethamphetamine (MDMA) in man." Thesis, King's College London (University of London), 1999. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.313776.

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45

Leão, Anabela Pereira. "Lesões musculares esqueléticas induzidas pela MDMA (‘Ecstasy’) e pelo exercício físico." Master's thesis, Universidade de Aveiro, 2003. http://hdl.handle.net/10773/18837.

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Mestrado em Métodos Biomoleculares Avançados<br>Com este trabalho procurou-se estudar, no músculo soleus de ratinho, os efeitos da administração da MDMA e da sua associação com o exercício físico. Para isso utilizaram-se 72 ratinhos Charles River CD1, distribuídos ao acaso por quatro grupos experimentais (n=18/grupo), que foram sujeitos à administração intraperitoneal de soro fisiológico e/ou 3,4- metilenodioxometanfetamina (MDMA) na dose de 10 mg/Kg. Destes grupos organizaram-se subgrupos (n=6), dos quais alguns foram submetidos ao exercício físico em tapete rolante, no plano horizonta
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46

Hoshi, Rosa. "The neuropharmacological, cognitive and mood effects of ±3,4-methylenedioxymethamphetamine (MDMA, 'ecstasy')." Thesis, University College London (University of London), 2006. http://discovery.ucl.ac.uk/1445586/.

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This thesis investigates the sub-acute and long-term neuropharmacological, cognitive and mood effects of ecstasy use. The first Positron Emission Tomography (PET) study used the 18F-dopa ligand to assess presynaptic dopaminergic function in ex-ecstasy users, poly-drug controls and drug-naive controls. Increased F-dopa uptake was found in the putamen of ex-ecstasy users compared to controls. This could suggest a compensatory upregulation of the dopaminergic system. The second PET study used the 11CDASB ligand to assess 5- HT transporter density in ex-ecstasy users, poly-drug controls and drug-n
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Soar, Kirstie. "Problematic and non-problematic ecstasy (MDMA) usage : cognitive and psychopathological aspects." Thesis, University of East London, 2005. http://roar.uel.ac.uk/3408/.

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This research thesis aimed to explore the apparent dichotomy of ecstasy (MDMA) users who report cognitive and psychopathological problems which they attribute to their use of this drug ("problematic" users), and those who report no adverse ecstasy-related effects ("nonproblematic" users). In the first study, possible psychological sequalae linked to past ecstasy use were assessed in problematic and non-problematic ecstasy users using the modified Brief Symptom Inventory, aspects of the Rivermead Behavioural Memory Test, Tower of London and Auditory Verbal Learning Task. Problematic ecstasy use
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O'Mahony, Brian. "Clinical and toxicological significance of the involvement of the cytocrhome p450 system in the metabolism of 3,4-methylenedioxymethamphetamine." Doctoral thesis, Universitat Pompeu Fabra, 2008. http://hdl.handle.net/10803/7209.

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La 3,4-metilenodioximetanfetamina (MDMA, éxtasis) es una anfetamina sustituida de consumo frecuente y abusivo. La enzima principal que participa en el metabolismo de fase I de la MDMA, la isoforma 2D6 (CYP2D6) del citocromo P450, resulta también inhibida por la MDMA. Además, ésta es a la vez metabolizada por otras isoformas de CYP, por ejemplo la CYP1A2. La contribución de esta enzima y los posibles cambios en su actividad tras una administración de MDMA nunca han sido estudiados in-vivo. En consecuencia, se realizó un ensayo clínico donde los marcadores, dextrometorfano y cafeína se administr
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Cirtautas, Alfonsas. "Programavimo kalbų taikymas modelių transformacijoms realizuoti MDA architektūroje." Master's thesis, Lithuanian Academic Libraries Network (LABT), 2005. http://vddb.library.lt/obj/LT-eLABa-0001:E.02~2005~D_20050527_103708-63400.

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Presented work covers one of the most important areas of OMG’s model driven architecture (MDA) – problems of object model transformations. Based on research of OMG specifications and other sources, author analyzes transformation process, states importance of modeling and metamodeling for designing of UML like modeling languages. Research work describes designed PIM ant PSM metamodels of aggregate systems. Structure and syntax of ATL and MTL model transformation languages was introduced. Author gives a short overview of model editors and graphical representation for these languages, created usi
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Ambraziūnas, Martas. "Enterprise model based MDA information systems engineering method." Doctoral thesis, Lithuanian Academic Libraries Network (LABT), 2014. http://vddb.library.lt/obj/LT-eLABa-0001:E.02~2014~D_20141111_114310-77387.

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Although new methods of information systems engineering are being researched and developed, they are empirical in nature. The problem domain knowledge acquisition process relies heavily on the system analyst and user; therefore it is not clear whether the knowledge of the problem domain is comprehensive. This may lead to occurrence of logical gaps, misinterpretation of system requirements, thus causing issues for project. The research work is meant to develop new IS engineering method that will allow validation of the problem domain knowledge against formal criteria. In order to create such me
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