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Journal articles on the topic 'MDNA'

Author: Grafiati

Published: 6 September 2023

Last updated: 25 July 2025

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1

Chandran, Harish, Nikhil Gopalkrishnan, Bernard Yurke, and John Reif. "Meta-DNA: synthetic biology via DNA nanostructures and hybridization reactions." Journal of The Royal Society Interface 9, no. 72 (2012): 1637–53. http://dx.doi.org/10.1098/rsif.2011.0819.

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Can a wide range of complex biochemical behaviour arise from repeated applications of a highly reduced class of interactions? In particular, can the range of DNA manipulations achieved by protein enzymes be simulated via simple DNA hybridization chemistry? In this work, we develop a biochemical system which we call meta-DNA (abbreviated as mDNA), based on strands of DNA as the only component molecules. Various enzymatic manipulations of these mDNA molecules are simulated via toehold-mediated DNA strand displacement reactions. We provide a formal model to describe the required properties and op

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Shockett, Penny, Januka Khanal, Alina Sitaula, and Robert Kraemer. "Decline in relative plasma cell-free mitochondrial DNA levels in response to prolonged moderate aerobic and eccentric exercise (HUM1P.306)." Journal of Immunology 194, no. 1_Supplement (2015): 52.31. http://dx.doi.org/10.4049/jimmunol.194.supp.52.31.

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Abstract Elevated plasma levels of cell-free mitochondrial DNA (cf-mDNA), a cell damage-associated molecular pattern (DAMP), contribute to neutrophil activation and inflammation in trauma patients, and may occur in cancer and autoimmunity. To further understand relationships between cf-mDNA released by tissue injury, inflammation, and health benefits of exercise, we conducted trial by time experiments for plasma cf-mDNA response to prolonged moderate aerobic exercise, and to eccentric exercise. Seven healthy moderately-trained young men (n=7) completed treadmill exercise trials for 90 min at 6

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Vallée, Nicolas, Sandrine Gaillard, André Peinnequin, Jean-Jacques Risso, and Jean-Eric Blatteau. "Evidence of cell damages caused by circulating bubbles: high level of free mitochondrial DNA in plasma of rats." Journal of Applied Physiology 115, no. 10 (2013): 1526–32. http://dx.doi.org/10.1152/japplphysiol.00025.2013.

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Bubble formation can occur in the vascular system after diving, leading to decompression sickness (DCS). DCS signs and symptoms range from minor to death. Too often, patients are admitted to a hyperbaric center with atypical symptoms, as bubbles cannot be detected anymore. In the absence of a relevant biomarker for humans, the therapeutic management remains difficult. As circulating DNA was found in the blood of healthy humans and animals, our study was made to correlate the extracellular mitochondrial DNA (mDNA) concentration with the occurrence of clinical DCS symptoms resulting from initial

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Peletiri, I. C., E. I. Ikeh, E. Nna, et al. "Quality of metagenomic DNA extracted for molecular identification of microorganisms from CSF samples of patients with suspected cerebrospinal meningitis in northern Nigeria." African Journal of Clinical and Experimental Microbiology 22, no. 2 (2021): 146–56. http://dx.doi.org/10.4314/ajcem.v22i2.6.

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Background: Following an increase in the practice of starting antimicrobial therapy prior to clinical sample collection, the ability to confirm pathogenic microorganisms of bacterial meningitis has decreased by approximately 30%. Culture results may be false negative when fastidious or culture-resistant bacteria are involved or when patient samples are obtained after antimicrobial therapy has started. Molecular diagnosis using PCR can be performed directly on clinical samples after metagenomic DNA (mDNA) extraction not requiring live organisms for a positive result. The specific objectives of

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Chen, Jenhui, Obinna Agbodike, and Lei Wang. "Memory-Based Deep Neural Attention (mDNA) for Cognitive Multi-Turn Response Retrieval in Task-Oriented Chatbots." Applied Sciences 10, no. 17 (2020): 5819. http://dx.doi.org/10.3390/app10175819.

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One of the important criteria used in judging the performance of a chatbot is the ability to provide meaningful and informative responses that correspond with the context of a user’s utterance. Nowadays, the number of enterprises adopting and relying on task-oriented chatbots for profit is increasing. Dialog errors and inappropriate response to user queries by chatbots can result in huge cost implications. To achieve high performance, recent AI chatbot models are increasingly adopting the Transformer positional encoding and the attention-based architecture. While the transformer performs optim

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de Laat, Paul, Richard R. Rodenburg, Nel Roeleveld, Saskia Koene, Jan A. Smeitink, and Mirian CH Janssen. "Six-year prospective follow-up study in 151 carriers of the mitochondrial DNA 3243 A>G variant." Journal of Medical Genetics 58, no. 1 (2020): 48–55. http://dx.doi.org/10.1136/jmedgenet-2019-106800.

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BackgroundThe mitochondrial DNA (mDNA) 3243A>G variant is the most common pathogenic variant of the mDNA. To interpret results of clinical trials in mitochondrial disease, it is important to have a clear understanding of the natural course of disease. To obtain more insight into the disease burden and the progression of disease in carriers of the mDNA 3243 A>G variant, we followed a cohort of 151 carriers from 61 families prospectively for up to 6 years.MethodsThe disease severity was scored using the Newcastle Mitochondrial Disease Adult Scale (NMDAS), including SF-36 quality of life (Q

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Smail, Emily, Brion Maher, Ann Moore, et al. "Links of Sleep Duration with Biomarkers of Accelerated Aging: the Baltimore Longitudinal Study of Aging." Innovation in Aging 5, Supplement_1 (2021): 665–66. http://dx.doi.org/10.1093/geroni/igab046.2512.

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Abstract Sleep disorders and sleep deprivation have been linked to markers of biological aging, including methylation change and increases in white blood cell and neutrophil counts. However, little is known regarding the association of sleep duration with biological markers of aging. We investigated links of self-reported sleep duration with biological aging markers in 615 participants in the Baltimore Longitudinal Study of Aging (BLSA) aged ≥50 years (mean = 71.0 ± 11.2, 49.6% women, 68.8% white) with data on self-reported sleep duration in hours (i.e., ≤6 (n=131), &gt;6 to 7 (n=234), &am

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Magnani, M., G. Brandi, A. Casabianca, et al. "2′,3′-Dideoxycytidine metabolism in a new drug-resistant cell line." Biochemical Journal 312, no. 1 (1995): 115–23. http://dx.doi.org/10.1042/bj3120115.

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2′,3′-Dideoxycytidine (ddC) is a nucleoside analogue that inhibits human immunodeficiency virus type 1 (HIV-1) replication in vitro and is currently used in the therapy of acquired immune deficiency syndrome (AIDS). This compound exerts a delayed cytotoxicity due to inhibition of mitochondrial DNA (mDNA) synthesis. Long-term exposure of U937 human monoblastoid cells to ddC resulted in a time- and concentration-dependent decrease in mDNA content and Rhodamine 123 fluorescence. However, after 2 months on 0.1 microM ddC, a drug-resistant cell line (U937-R) with 66% of the normal amount of mDNA wa

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Schuliga, Michael, Jane Read, Kaj E. C. Blokland, et al. "Self DNA perpetuates IPF lung fibroblast senescence in a cGAS-dependent manner." Clinical Science 134, no. 7 (2020): 889–905. http://dx.doi.org/10.1042/cs20191160.

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Abstract Senescence and mitochondrial stress are mutually reinforcing age-related processes that contribute to idiopathic pulmonary fibrosis (IPF); a lethal disease that manifests primarily in the elderly. Whilst evidence is accumulating that GMP-AMP synthase (cGAS) is crucial in perpetuating senescence by binding damaged DNA released into the cytosol, its role in IPF is not known. The present study examines the contributions of cGAS and self DNA to the senescence of lung fibroblasts from IPF patients (IPF-LFs) and age-matched controls (Ctrl-LFs). cGAS immunoreactivity was observed in regions

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Lobanovskaya, P. Y., L. N. Akimova, and E. E. Kheidorova. "Distribution and characteristics of <i>Ashworthius sidemi</i> Schulz, 1933 (Nematoda, Trichostrongylidae) in wild ungulates in Belarus." Proceedings of the National Academy of Sciences of Belarus, Biological Series 67, no. 2 (2022): 172–80. http://dx.doi.org/10.29235/1029-8940-2022-67-2-172-180.

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The material was collected during the period 2018‒2021 by dissection of internal organs of European bisons, red deers, European roe deers and elks. The found helminths were identified morphologically and using molecular genetic tools. Analysis of 16 ND4 mDNA sequences of A. sidemi revealed low level of genetic diversity which may indicate that Ashworthius sidemi in Belarus spread from one source.

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Godler, David E., and David J. Amor. "DNA methylation analysis for screening and diagnostic testing in neurodevelopmental disorders." Essays in Biochemistry 63, no. 6 (2019): 785–95. http://dx.doi.org/10.1042/ebc20190056.

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Abstract DNA methylation (mDNA) plays an important role in the pathogenesis of neurodevelopmental disorders (NDDs), however its use in diagnostic testing has been largely restricted to a handful of methods for locus-specific analysis in monogenic syndromes. Recent studies employing genome-wide methylation analysis (GWMA) have explored utility of a single array-based test to detect methylation changes in probands negative by exome sequencing, and to diagnose different monogenic NDDs with defined epigenetic signatures. While this may be a more efficient approach, several significant barriers rem

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Uzunov, Blagoy, Katerina Stefanova, Mariana Radkova, Jean-Pierre Descy, Georg Gärtner, and Maya Stoyneva-Gärtner. "First Report on Microcystis as a Potential Microviridin Producer in Bulgarian Waterbodies." Toxins 13, no. 7 (2021): 448. http://dx.doi.org/10.3390/toxins13070448.

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Bulgaria, situated on the Balkan Peninsula, is rich in small and shallow, natural and man-made non-lotic waterbodies, which are threatened by blooms of Cyanoprokaryota/Cyanobacteria. Although cyanotoxins in Bulgarian surface waters are receiving increased attention, there is no information on microviridins and their producers. This paper presents results from a phytoplankton study, conducted in August 2019 in three lakes (Durankulak, Vaya, Uzungeren) and five reservoirs (Duvanli, Mandra, Poroy, Sinyata Reka, Zhrebchevo) in which a molecular-genetic analysis (PCR based on the precursor mdnA gen

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Choi, Byung-Moon, Bong Jin Kang, Ho-Yong Yun, Bokyoung Jeon, Ji-Yeon Bang, and Gyu-Jeong Noh. "Performance of the MP570T pulse oximeter in volunteers participating in the controlled desaturation study: a comparison of seven probes." Anesthesia and Pain Medicine 15, no. 3 (2020): 371–77. http://dx.doi.org/10.17085/apm.20028.

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Background: The performance of the pulse oximeter was evaluated based on the ISO 80601-2-61:2011 (E) guidelines. This study aimed to determine whether the various finger probes of the MP570T pulse oximeter (MEK-ICS Co., Ltd., Korea) would provide clinically reliable peripheral oxygen saturation (SpO2) readings over a range of 70100% arterial oxygen saturation (SaO2) during non-motion conditions.Methods: Each volunteer (n = 12) was connected to a breathing circuit for the administration of a hypoxic gas mixture. For frequent blood sampling, an arterial cannula was placed in a radial artery. Th

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Liedtke, Victoria, Laura Rose, Rico Hiemann, et al. "Over-Expression of LEDGF/p75 in HEp-2 Cells Enhances Autoimmune IgG Response in Patients with Benign Prostatic Hyperplasia—A Novel Diagnostic Approach with Therapeutic Consequence?" International Journal of Molecular Sciences 24, no. 7 (2023): 6166. http://dx.doi.org/10.3390/ijms24076166.

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Lens epithelium-derived growth factor splice variant of 75 kDa (LEDGF/p75) is an autoantigen over-expressed in solid tumors and acts as a stress-related transcriptional co-activator. Participation of autoimmune responses in the pathophysiology of benign prostatic hyperplasia (PBH) and a corresponding immunosuppressive therapy by TNFalpha antagonists has been recently suggested. Thus, autoAb testing could aid in the diagnosis of BPH patients profiting from such therapy. We generated CRISPR/Cas9 modified HEp-2 LEDGF knock-out (KO) and HEp-2 LEDGF/p75 over-expressing (OE) cells and examined IgG a

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Tessa, Alessandro, Aldo Giannotti, Luigi Tieri, Laura Vilarinho, Giacomo Marotta, and Filippo M. Santorelli. "Maternally inherited deafness associated with a T1095C mutation in the mDNA." European Journal of Human Genetics 9, no. 2 (2001): 147–49. http://dx.doi.org/10.1038/sj.ejhg.5200601.

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Grzeczka, Arkadiusz, Szymon Graczyk, and Pawel Kordowitzki. "DNA Methylation and Telomeres—Their Impact on the Occurrence of Atrial Fibrillation during Cardiac Aging." International Journal of Molecular Sciences 24, no. 21 (2023): 15699. http://dx.doi.org/10.3390/ijms242115699.

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Atrial fibrillation (AF) is the most common arrhythmia in humans. AF is characterized by irregular and increased atrial muscle activation. This high-frequency activation obliterates the synchronous work of the atria and ventricles, reducing myocardial performance, which can lead to severe heart failure or stroke. The risk of developing atrial fibrillation depends largely on the patient’s history. Cardiovascular diseases are considered aging-related pathologies; therefore, deciphering the role of telomeres and DNA methylation (mDNA), two hallmarks of aging, is likely to contribute to a better u

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Pirnay, Stephane O., Tsadik T. Abraham, and Marilyn A. Huestis. "Sensitive Gas Chromatography-Mass Spectrometry Method for Simultaneous Measurement of MDEA, MDMA, and Metabolites HMA, MDA, and HMMA in Human Urine." Clinical Chemistry 52, no. 9 (2006): 1728–34. http://dx.doi.org/10.1373/clinchem.2006.069054.

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Abstract Background: A sensitive gas chromatography-mass spectrometry method was developed and validated for the simultaneous measurement of MDEA, MDMA, and its metabolites, 3,4-methylenedioxy-N-ethylamphetamine (MDEA), 3,4-methylenedioxymethamphetamine (MDMA or Ecstasy), and its metabolites, 4-hydroxy-3-methoxyamphetamine (HMA), 3,4-methylenedioxyamphetamine (MDA), and 4-hydroxy-3-methoxyamphetamine (HMMA) in human urine. Methods: We hydrolyzed 1 mL urine, fortified with MDMA-d5, MDA-d5, and MDEA-d6, with 100 μL of concentrated hydrochloric acid at 120 °C for 40 min, then added 100 μL 10 N so

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Nye, Verity, Jon Copley, Sophie Plouviez, and Cindy Lee Van Dover. "A new species ofLebbeus(Crustacea: Decapoda: Caridea: Hippolytidae) from the Von Damm Vent Field, Caribbean Sea." Journal of the Marine Biological Association of the United Kingdom 93, no. 3 (2012): 741–51. http://dx.doi.org/10.1017/s0025315412000884.

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A new species of the hippolytid shrimp genusLebbeusWhite, 1847 is described from the Von Damm Vent Field (VDVF) on the Mid-Cayman Spreading Centre, Caribbean Sea, at 2294 m water depth.Lebbeus virentovasp. nov. is defined and illustrated from seven specimens, with brief notes on its distribution and habitat. Molecular phylogenetic data from the COI mDNA region are used to analyse the species’ phylogenetic position, and its morphology is compared with previously described species. This new species represents the second family of caridean shrimp to be reported from the VDVF.Lebbeus virentovasp.

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Ziemert, Nadine, Keishi Ishida, Annika Weiz, Christian Hertweck, and Elke Dittmann. "Exploiting the Natural Diversity of Microviridin Gene Clusters for Discovery of Novel Tricyclic Depsipeptides." Applied and Environmental Microbiology 76, no. 11 (2010): 3568–74. http://dx.doi.org/10.1128/aem.02858-09.

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ABSTRACT Microviridins are ribosomally synthesized tricyclic depsipeptides produced by different genera of cyanobacteria. The prevalence of the microviridin gene clusters and the natural diversity of microviridin precursor sequences are currently unknown. Screening of laboratory strains and field samples of the bloom-forming freshwater cyanobacterium Microcystis via PCR revealed global occurrence of the microviridin pathway and an unexpected natural variety. We could detect 15 new variants of the precursor gene mdnA encoding microviridin backbones that differ in up to 4 amino acid positions fr

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Chen, Hai-Ying, Jia-Long Guo, and Zhan-Guo Li. "Significance of anti-cell membrane-associated DNA (mDNA) antibodies in systemic lupus erythematosus." Clinical Rheumatology 27, no. 2 (2007): 183–87. http://dx.doi.org/10.1007/s10067-007-0675-1.

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Zhao, Yufen, Wenjie Cheng, Corinne L. D. Gibb, Goutam Gupta, and Neville R. Kallenbach. "HMG Box Proteins Interact With Multiple Tandemly Repeated (GCC)n•(GGC)mDNA Sequences." Journal of Biomolecular Structure and Dynamics 14, no. 2 (1996): 235–38. http://dx.doi.org/10.1080/07391102.1996.10508113.

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Jorge De Souza, Tiago Alves. "Mitochondrial DNA: From Forensic Genetics to the Origins of Humanity." Kerygma 17, no. 1 (2023): e01568. http://dx.doi.org/10.19141/1809-2454.kerygma.v17.n1.pe01568.

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Mitochondria are cellular organelles that provide cellular energy. Along with chloroplasts of plant cells, mitochondria are the only organelles that have genetic material. These peculiarities make mitochondrial DNA (DNA) one of the main research topics in the field of Cytology and Genetics. Interest shared by Criminalistics, which uses mDNA analysis for forensic identification of DNA traces in which nuclear DNA analysis is not possible. In addition to being used in forensic investigation, mtDNA analysis has also been widely used in paleoanthropological investigation through the elaboration of

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Berbegal, Carmen, Lucía Polo, Victoria Lizama, et al. "Influence of Native S. cerevisiae Strains on the Final Characteristics of “Pago” Garnacha Wines from East Spain." Beverages 9, no. 1 (2023): 17. http://dx.doi.org/10.3390/beverages9010017.

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This work studies the variability of the Saccharomyces cerevisiae present during the spontaneous fermentation of Garnacha grapes’ musts from a “Pago” winery from the east of Spain. The parameters used to select yeast are those related to growth, fermentative behaviour, and the influence on the wine’s aroma and polyphenolic composition. Yeast identification was performed by ITS analysis and typed by Hinfl mDNA restriction profile analysis. Growth and metabolic characteristics of the isolates were determined by laboratory-scale fermentations of sterile Garnacha must, and the composition of the p

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Belhadj-Tahar, Hafid, Pierre Payoux, Mathieu Tafani, Yvon Coulais, Serge Calet, and Azzedine Bousseksou. "Toxicological Methods for Tracing Drug Abuse: Chromatographic, Spectroscopic and Biological Characterisation of Ecstasy Derivatives." Archives of Industrial Hygiene and Toxicology 61, no. 1 (2010): 53–59. http://dx.doi.org/10.2478/10004-1254-61-2010-1937.

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Toxicological Methods for Tracing Drug Abuse: Chromatographic, Spectroscopic and Biological Characterisation of Ecstasy DerivativesAnalysis often reveals variability in the composition of ecstasy pills from pure 3,4-methylenedioxymethamphetamine (MDMA) to mixtures of MDMA derivatives, amphetamine, and other unidentified substances. For a comprehensive toxicological analysis one needs to know all steps to MDMA synthesis which may originate impurities. The aim of this study was to synthesise and determine the chemical-physical andin vitrobiological properties of a series of MDMA derivatives.3,4-

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Kim, Yoo Taek, Seung Gu Kang, and Chang Sam Kim. "Lightweight Aggregate Made of Desulfurized Fly Ash and Bottom Ash after Magnetic Separation." Applied Mechanics and Materials 174-177 (May 2012): 1450–54. http://dx.doi.org/10.4028/www.scientific.net/amm.174-177.1450.

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This research provides a comparison of ALAs which was made up of two different raw materials, that is, MDFA and MDBA which were produced from fluidized bed type boiler of power plant and then magnetically separated. ALAs made up of MDFA had too much liquid phase at high temperature; on the other hand, those made up of MDBA showed a black core region as well as good distribution of various sizes of pores inside ALA. Although a good quality of ALA can be made of MDBA only, the optimum composition was obtained under the conditions of MDBA:DS=5:5 and at 1200°C. Nonetheless for its high sintering t

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Schmidt, Vanina, Ornella Lo Giusto, Gabriela Di Puglia, Florencia Martucci, Analía Alvarez Ituraín, and Ayelén Bustamante. "Riesgos y cuidados de jóvenes usuarios/as de sustancias psicoactivas. Una aproximación cuantitativa a sus prácticas en eventos nocturnos de la ciudad de Buenos Aires." OBETS. Revista de Ciencias Sociales 18, no. 2 (2023): 365–80. http://dx.doi.org/10.14198/obets.23150.

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Introducción. El presente estudio indaga los riesgos y cuidados de jóvenes usuarios/as de sustancias psicoactivas que asisten a eventos nocturnos de presencia masiva. Como objetivo adicional, se construyó y validó un instrumento para evaluar las prácticas que se desarrollan en tales escenarios. Método. Participantes: 115 sujetos usuarios/as de sustancias psicoactivas (65% mujeres y 35% varones) de 18 a 30 años que asistían a eventos nocturnos de presencia masiva de la Ciudad de Buenos Aires/Argentina. Instrumentos: Cuestionario sociodemográfico, Escala de Prácticas de Riesgo y Cuidados en Esce

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Peters, Frank T., Nele Samyn, Thomas Kraemer, Wim J. Riedel, and Hans H. Maurer. "Negative-Ion Chemical Ionization Gas Chromatography–Mass Spectrometry Assay for Enantioselective Measurement of Amphetamines in Oral Fluid: Application to a Controlled Study with MDMA and Driving Under the Influence Cases." Clinical Chemistry 53, no. 4 (2007): 702–10. http://dx.doi.org/10.1373/clinchem.2006.081547.

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Abstract Background: Enantioselective analysis of amphetamine (AM), methamphetamine (MA), 3,4-methylenedioxyamphetamine (MDA), 3,4-methylenedioxymethamphetamine (MDMA), and 3,4-methylenedioxyethylamphetamine (MDEA) helps interpret toxicological results. Methods have been described for various matrices, but so far not for oral fluid, a matrix of increasing importance in testing for drugs of abuse, especially in the context of driving under the influence of drugs (DUID). Methods: After dilution with 200 μL carbonate buffer (pH 9), oral fluid samples (10–50 μL) were derivatized with S-heptafluoro

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Kolbrich, Erin A., Ross H. Lowe, and Marilyn A. Huestis. "Two-Dimensional Gas Chromatography/Electron-Impact Mass Spectrometry with Cryofocusing for Simultaneous Quantification of MDMA, MDA, HMMA, HMA, and MDEA in Human Plasma." Clinical Chemistry 54, no. 2 (2008): 379–87. http://dx.doi.org/10.1373/clinchem.2007.096800.

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Abstract Background: 3,4-Methylenedioxymethamphetamine (MDMA, or Ecstasy) is a popular recreational drug. Analysis of MDMA and metabolites in human plasma, particularly in pharmacokinetic studies, requires low limits of quantification. Two-dimensional GC/MS with cryofocusing is a chromatographic technique recognized for its increased selectivity and resolution. Methods: This method simultaneously quantifies 3,4-methylenedioxyethylamphetamine (MDEA), MDMA, and its metabolites, 3,4-methylenedioxyamphetamine (MDA), 4-hydroxy-3-methoxymethamphetamine (HMMA), and 4-hydroxy-3-methoxyamphetamine (HMA

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Peters, Frank T., Nele Samyn, Caroline TJ Lamers, et al. "Drug Testing in Blood: Validated Negative-Ion Chemical Ionization Gas Chromatographic–Mass Spectrometric Assay for Enantioselective Measurement of the Designer Drugs MDEA, MDMA, and MDA and Its Application to Samples from a Controlled Study with MDMA." Clinical Chemistry 51, no. 10 (2005): 1811–22. http://dx.doi.org/10.1373/clinchem.2005.052746.

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Abstract Background: The enantiomers of the designer drugs 3,4-methylenedioxyamphetamine (MDA), 3,4-methylenedioxymethamphetamine (MDMA), and 3,4-methylenedioxyethylamphetamine (MDEA) differ in their pharmacologic and toxicologic potency. The aim of this study was to develop an assay for measuring these enantiomers in small plasma volumes and to analyze samples from a controlled study with MDMA. Methods: The analytes were extracted from ≤0.2 mL of plasma by mixed-mode solid-phase extraction. After derivatization with S-(−)-heptafluorobutyrylprolyl chloride, the resulting diastereomers were sep

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Nye, Verity, Jon Copley, Katrin Linse, and Sophie Plouviez. "Iheyaspira bathycodon new species (Vetigastropoda: Trochoidea: Turbinidae: Skeneinae) from the Von Damm Vent Field, Mid-Cayman Spreading Centre, Caribbean." Journal of the Marine Biological Association of the United Kingdom 93, no. 4 (2012): 1017–24. http://dx.doi.org/10.1017/s0025315412000823.

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Iheyaspira bathycodon sp. nov. is described from the Von Damm Vent Field on the world's deepest spreading centre, the Mid-Cayman Spreading Centre (MCSC), Caribbean, at 2300 m depth. The new species is defined and illustrated from 11 specimens, with brief notes on habitat and known distribution. Molecular phylogenetic data from partial COI mDNA, 16S rDNA and nuclear 18S rDNA regions are used to analyse the species’ phylogenetic position and its morphology is compared with previously described skeneid and vent taxa. The new species is distinguished from the most closely allied vent species, Ihey

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Laughrea, Michael, and John Tam. "Ribosomal protein S1 and initiation factor IF3 do not promote the ribosomal binding of ~ 19-nucleotide-long mDNA and mRNA models." Biochemistry and Cell Biology 67, no. 11-12 (1989): 812–17. http://dx.doi.org/10.1139/o89-120.

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A number of model mDNAs and mRNAs, about 19 nucleotides in length, were obtained by automated synthesis and T7 RNA polymerase directed transcription from synthetic DNA templates, respectively. These mDNAs and mRNAs had Shine-Dalgarno sequences that were four to eight nucleotides long and their sequence was similar to the R17 coat protein initiation site. The effect of S1 or initiation factors (IFs) on the rate and extent of ribosomal binding of these mDNAs and mRNAs was investigated by nitrocellulose filtration. No effect was detected, suggesting that the main function of S1 or IFs included ne

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Holmes, Laurens, Andrew Lim, Camillia R. Comeaux, Kirk W. Dabney та Osatohamwen Okundaye. "DNA Methylation of Candidate Genes (ACE II, IFN-γ, AGTR 1, CKG, ADD1, SCNN1B and TLR2) in Essential Hypertension: A Systematic Review and Quantitative Evidence Synthesis". International Journal of Environmental Research and Public Health 16, № 23 (2019): 4829. http://dx.doi.org/10.3390/ijerph16234829.

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Physical, chemical, and social environments adversely affect the molecular process and results in cell signal transduction and the subsequent transcription factor dysregulation, leading to impaired gene expression and abnormal protein synthesis. Stressful environments such as social adversity, isolation, sustained social threats, physical inactivity, and highly methylated diets predispose individuals to molecular level alterations such as aberrant epigenomic modulations that affect homeostasis and hemodynamics. With cardiovascular disease as the leading cause of mortality in the US and blacks/

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Zhu, Liang, Xingqing Feng, Shenhao Yang, et al. "Colorimetric detection of immunomagnetically captured rare number CTCs using mDNA-wrapped single-walled carbon nanotubes." Biosensors and Bioelectronics 172 (January 2021): 112780. http://dx.doi.org/10.1016/j.bios.2020.112780.

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Castrillo, David, Noemi Neira, and Pilar Blanco. "Saccharomyces cerevisiae Strain Diversity Associated with Spontaneous Fermentations in Organic Wineries from Galicia (NW Spain)." Fermentation 6, no. 3 (2020): 89. http://dx.doi.org/10.3390/fermentation6030089.

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Yeast play an essential role in wine quality. The dynamics of yeast strains during fermentation determine the final chemical and sensory characteristics of wines. This study aims to evaluate the Saccharomyces cerevisiae strains diversity in organic wineries from Galicia (NW Spain). Samples from spontaneous fermentations were taken in five wineries over three consecutive years (2013 to 2015). The samples were transported to the laboratory and processed following standard methodology for yeast isolation. S. cerevisiae strains were differentiated by mDNA-RFLPs. A total of 66 different strains wer

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Tanaka, Keiko, Takashi Shiina, Taketeru Tomita, et al. "Evolutionary Relations of Hexanchiformes Deep-Sea Sharks Elucidated by Whole Mitochondrial Genome Sequences." BioMed Research International 2013 (2013): 1–11. http://dx.doi.org/10.1155/2013/147064.

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Hexanchiformes is regarded as a monophyletic taxon, but the morphological and genetic relationships between the five extant species within the order are still uncertain. In this study, we determined the whole mitochondrial DNA (mtDNA) sequences of seven sharks including representatives of the five Hexanchiformes, one squaliform, and one carcharhiniform and inferred the phylogenetic relationships among those species and 12 other Chondrichthyes (cartilaginous fishes) species for which the complete mitogenome is available. The monophyly of Hexanchiformes and its close relation with all other Squa

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Clauwaert, Karine M., Jan F. Van Bocxlaer, Els A. De Letter, Serge Van Calenbergh, Willy E. Lambert, and André P. De Leenheer. "Determination of the Designer Drugs 3,4-Methylenedioxymethamphetamine, 3,4-Methylenedioxyethylamphetamine, and 3,4-Methylenedioxyamphetamine with HPLC and Fluorescence Detection in Whole Blood, Serum, Vitreous Humor, and Urine." Clinical Chemistry 46, no. 12 (2000): 1968–77. http://dx.doi.org/10.1093/clinchem/46.12.1968.

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Abstract Background: The popular designer drugs 3,4-methylenedioxymethamphetamine (MDMA) and 3,4-methylenedioxyethylamphetamine (MDEA) can be determined in serum, whole blood, and urine, but also in vitreous humor. The latter matrix is interesting when dealing with decomposed bodies in a toxicological setting. Methods: After extraction, chromatographic separation was achieved on a narrow-bore C18 column by gradient elution with fluorometric detection; results were confirmed by liquid chromatography-tandem mass spectrometry (LC-MS/MS). Results: The method was linear over the range of 2–1000 μg/

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Kumazawa, Takeshi, Kenji Hara, Chika Hasegawa, et al. "Fragmentation Pathways of Trifluoroacetyl Derivatives of Methamphetamine, Amphetamine, and Methylenedioxyphenylalkylamine Designer Drugs by Gas Chromatography/Mass Spectrometry." International Journal of Spectroscopy 2011 (August 22, 2011): 1–12. http://dx.doi.org/10.1155/2011/318148.

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Methamphetamine (MA), amphetamine (AM), and the methylenedioxyphenylalkylamine designer drugs, such as 3,4-methylenedioxymethamphetamine (MDMA), 3,4-methylenedioxyethylamphetamine (MDEA), N-methyl-1-(3,4-methylenedioxyphenyl)-2-butanamine (MBDB), 3,4-methylenedioxyamphetamine (MDA), and 3,4-(methylenedioxyphenyl)-2-butanamine (BDB), are widely abused as psychedelics. In this paper, these compounds were derivatized with trifluoroacetic (TFA) anhydride and analyzed by gas chromatography/mass spectrometry using electron ionization in positive mode. Gas chromatographic separation for TFA derivativ

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Sarhan, Moustafa, Ahmed Badry, Mahmoud Younes, and Mostafa Saleh. "Genetic diversity within Leiurus quinquestriatus (Scorpiones: Buthidae) populations in Egypt as inferred from 16S mDNA sequence analysis." Zoology in the Middle East 66, no. 3 (2020): 269–76. http://dx.doi.org/10.1080/09397140.2020.1788256.

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Hernández-Esquivel, Luz, Natalia Pavón, Mabel Buelna-Chontal, Héctor González-Pacheco, Javier Belmont, and Edmundo Chávez. "Cardioprotective properties of citicoline against hyperthyroidism-induced reperfusion damage in rat hearts." Biochemistry and Cell Biology 93, no. 3 (2015): 185–91. http://dx.doi.org/10.1139/bcb-2014-0116.

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Hyperthyroidism represents an increased risk factor for cardiovascular morbidity, especially when the heart is subjected to an ischemia/reperfusion process. The aim of this study was to explore the possible protective effect of the nucleotide citicoline on the susceptibility of hyperthyroid rat hearts to undergo reperfusion-induced damage, which is associated with mitochondrial dysfunction. Hence, we analyzed the protective effect of citicoline on the electrical behavior and on the mitochondrial function in rat hearts. Hyperthyroidism was established after a daily i.p. injection of triiodothyr

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Ahn, Jung Hyun, Kwang Hyun Byun, Bo Kyeung Jung, and Min Young Lee. "Screening of A1555G mDNA Variant Using U-TOP™HL Genotyping Kit in Korean Family with Progressive Hearing Loss." Korean Journal of Otorhinolaryngology-Head and Neck Surgery 64, no. 2 (2021): 108–13. http://dx.doi.org/10.3342/kjorl-hns.2020.00304.

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Recently, real-time polymerase chain reaction (PCR) using the U-TOP™HL Genotyping Kit has been introduced to detect genetic hearing loss caused by certain type of gene variants popularly found in Korea. The mitochondrial 12S ribosomal ribonucleic acid (rRNA) genes are related to aminoglycoside induced or non-syndromic, sensorineural hearing loss. Among them, 1555A>G is commonly found and reported worldwide. We are presenting the case of a mother and a son, who were screened by real-time PCR using the U-TOP™HL Genotyping Kit and were found both to have the mitochondrial 12s rRNA 1555A>G v

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Cassidy, Geraldine, and Clive G. Ballard. "Psychiatric sequelae of MDMA (ecstasy) and related drugs." Irish Journal of Psychological Medicine 11, no. 3 (1994): 132–33. http://dx.doi.org/10.1017/s0790966700014841.

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AbstractTwo cases of psychiatric disorder temporally related to the abuse of hallucinogenic amphetamines 3, 4 methylenedi-oxymethamphetamine (MDMA), methylenedioxyamphetamine (MDA) and methylenedioxyethylamphetamine (MDEA) are described, suggesting that a variety of psychiatric morbidity may be precipitated by abuse of these drugs, including paranoid psychosis, mixed affective psychosis and symptoms of obsessive compulsive disorder.

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Kamble, Shripat T. "Morphological Characterization and Molecular Mediated Genetic Variation of Thief Ants (Hymenoptera: Formicidae)." Sociobiology 59, no. 3 (2014): 617–31. http://dx.doi.org/10.13102/sociobiology.v59i3.537.

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The morphological characterization and molecular genetic variation were determined in populations of thief ants, Solenopsis molesta (Say). The genetic variations were elucidated using mitochondrial deoxyribonucleic acid (mDNA) sequences of cytochrome oxidase I. DNA from thief ants was extracted with Qiagen’s Gentra PUREGENE® DNA Isolation Kit using their solid tissue protocol. Polymerase chain reactions (PCR) were run on the extracted DNA using primers Lep-F1 (forward) and Lep-R1 (reverse). The DNA products were concentrated and purified by Microcon Centrifugal Filter Unit YM-100. Purified DNA

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Mohamed, Khaled M., and Abdulsallam Bakdash. "Comparison of 3 Derivatization Methods for the Analysis of Amphetamine-Related Drugs in Oral Fluid by Gas Chromatography-Mass Spectrometry." Analytical Chemistry Insights 12 (January 1, 2017): 117739011772753. http://dx.doi.org/10.1177/1177390117727533.

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The heptafluorobutyric anhydride (HFBA), pentafluoropropionic anhydride (PFPA), and trifluoroacetic anhydride (TFAA) are compared as derivatizing reagents to use as the optimal method for the analysis of 10 amphetamines and cathinones in oral fluid. The target compounds were amphetamine (AMP), methamphetamine (MA), 4-methylamphetamine, 3,4-methylenedioxyamphetamine (MDA), 3,4-methylenedioxymethamphetamine (MDMA), 3,4-methylenedioxy- N-ethylamphetamine (MDEA), cathinone (CAT), methcathinone, mephedrone, and ephedrine. Amphetamine-D5, MA-D5, MDA-D5, MDMA-D5, and MDEA-D5 use as internal standards

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Zgonjanin, Dragana, Eva Loncar, and Milos Tasic. "Analysis of forensic samples of "Ecstasy" tablets seized in Novi Sad during the 2004 year." Acta Periodica Technologica, no. 36 (2005): 247–59. http://dx.doi.org/10.2298/apt0536247z.

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The paper presents results of the analysis of illicit synthetic drugs in the form of tablets distributed under the name "Ecstasy", seized by the police in the broader area of Novi Sad 2004. A huge number of tablets has been analyzed (n=121), of various colours and with impressed symbols from the total amount of 93 seizures, which totally amounted to 1458 tablets. Regarding the number of seizures ecstasy (3,4-methylendioxy-N-meth-yl-amphetamine - MDMA) is dominant among all, and according to the quantity of seized tablets it is amphetamine (AP), while other amphetamine-type drugs (methamphetami

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Öztunç, Aysel, Armağan Önal, and Sidika Ertürk Toker. "Detection of Methamphetamine, Methylenedioxymethamphetamine, and 3,4-Methylenedioxy-N-ethylamphetamine in Spiked Plasma by HPLC and TLC." Journal of AOAC INTERNATIONAL 93, no. 2 (2010): 556–61. http://dx.doi.org/10.1093/jaoac/93.2.556.

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Abstract HPLC and TLC methods were developed for separation and detection of some amphetamine analogs: methamphetamine (MA); 3,4-methylenedioxymethamphetamine (MDMA, ecstasy); and 3,4-methylenedioxy-N-ethylamphetamine (MDEA) in spiked plasma samples. The methods are based on purple chromogens formed by displacement reaction of these secondary aliphatic amine-bearing drugs with 7,7,8,8-tetracyanoquinodimethane at 80C for 25 min. For HPLC, both normal phase (silica gel) and RP (C18) columns were used. With the former, good detection limits in plasma were obtained with a 6 min run: 70, 100, and 5

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Noggle, F. Taylor, Jack DeRuiter, and Melinda J. Long. "Spectrophotometric and Liquid Chromatographic Identification of 3,4-Methylenedioxyphenylisopropylamine and Its N-Methyl and N-Ethyl Homologs." Journal of AOAC INTERNATIONAL 69, no. 4 (1986): 681–86. http://dx.doi.org/10.1093/jaoac/69.4.681.

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Abstract 3,4-Methylenedioxyphenylisopropylamine (MDA) is an hallucinogenic drug that somewhat resembles lysergic acid diethylamide (LSD) in its effects. Recently, widespread abuse of the N-methyl homolog (MDMA) of MDA has led to federal control. This article reports on the synthesis of the N-ethyl homolog (MDEA) of MDA as well as spectrophotometric and chromatographic methods for identification of the 3 homologs.

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Berezina, Tetiana A., Mykola P. Kopytsya, Olga V. Petyunina, et al. "Lower Circulating Cell-Free Mitochondrial DNA Is Associated with Heart Failure in Type 2 Diabetes Mellitus Patients." Cardiogenetics 13, no. 1 (2023): 15–30. http://dx.doi.org/10.3390/cardiogenetics13010003.

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Cell-free nuclear (cf-nDNA) and mitochondrial (cf-mDNA) DNA are released from damaged cells in type 2 diabetes mellitus (T2DM) patients, contributing to adverse cardiac remodeling, vascular dysfunction, and inflammation. The purpose of this study was to correlate the presence and type of cf-DNAs with HF in T2DM patients. A total of 612 T2DM patients were prescreened by using a local database, and 240 patients (120 non-HF and 120 HF individuals) were ultimately selected. The collection of medical information, including both echocardiography and Doppler imagery, as well as the assessment of bioc

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Hensley, D., and J. T. Cody. "Simultaneous Determination of Amphetamine, Methamphetamine, Methylenedioxyamphetamine (MDA), Methylenedioxymethamphetamine (MDMA), and Methylenedioxyethylamphetamine (MDEA) Enantiomers by GC-MS." Journal of Analytical Toxicology 23, no. 6 (1999): 518–23. http://dx.doi.org/10.1093/jat/23.6.518.

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DACOSTA, J., and A. CHASIN. "Determination of MDMA, MDEA and MDA in urine by high performance liquid chromatography with fluorescence detection." Journal of Chromatography B 811, no. 1 (2004): 41–45. http://dx.doi.org/10.1016/s1570-0232(04)00630-0.

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DACOSTA, J., and A. CHASIN. "Determination of MDMA, MDEA and MDA in urine by high performance liquid chromatography with fluorescence detection." Journal of Chromatography B 811, no. 1 (2004): 41–45. http://dx.doi.org/10.1016/j.jchromb.2004.03.076.

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