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Journal articles on the topic 'MDR XDR PDR ANTIMICROBIAL RESISTANCE MEXICO'

Author: Grafiati

Published: 5 June 2025

Last updated: 2 August 2025

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1

Luis, Arturo Camacho Silvas, Horacio Portillo Gallo Jorge, Cecilia Ishida Gutiérrez María, et al. "Clinical factors associated with bacterial resistance derived from health care in Chihuahua, Mexico." International Journal Of Medical Science And Clinical Research Studies 03, no. 04 (2023): 684–92. https://doi.org/10.5281/zenodo.7824527.

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Objective: Describe the profile of Multidrug Resistance (MDR), Extended Resistance (XDR) and Pan-Resistance (PDR) to antibacterials and identify the associated clinical factors in a hospital in Chihuahua, Mexico.   Materials and methods: An observational, analytical, case-control study was carried out during the period from January 2018 to December 2020. From 308 clinical records, 506 bacteria were isolated, the variables included previous admission and treatment, days of hospital stay, site of infection, days of antibiotic use, use of 2 or more antibiotics, relationship with nosocomial i

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Angulo-Zamudio, Uriel A., Maria Luisa Velazquez-Meza, Jesus J. Martinez-Garcia, et al. "Characteristics of Neonates with Sepsis Associated with Antimicrobial Resistance and Mortality in a Tertiary Hospital in Mexico: A Retrospective Observational Study." Pathogens 14, no. 6 (2025): 588. https://doi.org/10.3390/pathogens14060588.

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The objective of this study was to determine the epidemiological, clinical, and laboratory characteristics of newborns with sepsis in northwestern Mexico, identify the microorganisms causing early- and late-onset sepsis, and assess antimicrobial resistance. Additionally, it sought to associate neonatal characteristics with antimicrobial resistance or mortality. A retrospective study was conducted from August 2021 to April 2023, during which 8382 neonatal clinical records were analyzed to collect epidemiological, clinical, and laboratory characteristics, as well as microorganisms isolated from

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Tapia-Pastrana, Gabriela, Metztli Rojas-Bautista, Pilar Hernández-Pérez, et al. "Virulence genes, antimicrobial resistance profile, phylotyping and pathotyping of diarrheagenic Escherichia coli isolated from children in Southwest Mexico." PLOS ONE 19, no. 3 (2024): e0300304. http://dx.doi.org/10.1371/journal.pone.0300304.

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Diarrheagenic E. coli (DEC) strains are one of the most important etiology factors causing diarrhea in children worldwide, especially in developing countries. DEC strains have characteristic virulence factors; however, other supplemental virulence genes (SVG) may contribute to the development of diarrhea in children. Therefore, this study aimed to determine the prevalence of DEC in children with diarrhea in southwestern Mexico and to associate childhood symptoms, SVG, and pathotypes with diarrhea-causing DEC strains. DEC strains were isolated from 230 children with diarrhea aged 0–60 months fr

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Basak, Silpi, Priyanka Singh, and Monali Rajurkar. "Multidrug Resistant and Extensively Drug Resistant Bacteria: A Study." Journal of Pathogens 2016 (2016): 1–5. http://dx.doi.org/10.1155/2016/4065603.

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Background and Objective. Antimicrobial resistance is now a major challenge to clinicians for treating patients. Hence, this short term study was undertaken to detect the incidence of multidrug-resistant (MDR), extensively drug-resistant (XDR), and pandrug-resistant (PDR) bacterial isolates in a tertiary care hospital.Material and Methods. The clinical samples were cultured and bacterial strains were identified in the department of microbiology. The antibiotic susceptibility profile of different bacterial isolates was studied to detect MDR, XDR, and PDR bacteria.Results. The antibiotic suscept

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John-Onwe, Beatrice Ngozi, Ugonna Cassandra Aniokete, Francis Amadi Ibiam, Ikemesit Udeme Peter, Chidinma Stacy Iroha, and Ifeanyichukwu Romanus Iroha. "Dissemination of Multidrug-Resistant, Extensively Drug Resistant and Pandrug-Resistant Pseudomonas aeruginosa Isolates among In-Patients and Out-Patients in a Multi-Profile Health Care Settings." Journal of Advances in Microbiology 23, no. 10 (2023): 109–15. http://dx.doi.org/10.9734/jamb/2023/v23i10761.

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Pseudomonas aeruginosa is one of the most life-threatening pathogens, especially in healthcare settings, and a main contributor to multi-drug resistance (MDR), extensive-drug resistance (XDR), and pan-drug resistant (PDR) phenotypes. However, there is limited data on the degree of resistance of these isolates in this region. This study seeks to determine the distribution of MDR, XDR, and PDR Pseudomonas aeruginosa strains from different patient groups. A total of five hundred (500) non-duplicated strains of Pseudomonas aeruginosa of human clinical samples were collected from the Microbiology L

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Inusah, Abass, Elvis Quansah, Kwabena Fosu, and Isaac Dadzie. "Resistance Status of Bacteria from a Health Facility in Ghana: A Retrospective Study." Journal of Pathogens 2021 (March 4, 2021): 1–7. http://dx.doi.org/10.1155/2021/6648247.

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Background. Regardless of the global concerted effort to control the development and spread of antimicrobial resistance, increasing cases are continually documented at many medical centres. This situation is reinforced by inadequate information on the trend of resistance resulting from lack of regular antimicrobial resistance surveillance. The present study sought to detect the number of multidrug-resistant (MDR), extended drug-resistant (XDR), and pandrug-resistant (PDR) bacterial isolates at a health facility in Ghana from January 2018 to July 2020. Method. A total of 800 data on antimicrobi

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Souza, Gregory Lauar, Rhayssa Fernanda de Andrade Rocha, Andressa Do nascimento Silveira, et al. "2475. Incidence of Multidrug-Resistant, Extensively Drug-Resistant and Pandrug-Resistant Gram-Negative Bacteria in Brazilian Intensive Care Units." Open Forum Infectious Diseases 6, Supplement_2 (2019): S857. http://dx.doi.org/10.1093/ofid/ofz360.2153.

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Abstract Background The Centers for Disease Control and Prevention (CDC) proposed standard definitions for acquired resistance in bacterias. Resistant bacteria were categorized as multidrug-resistant (MDR), extensively drug-resistant (XDR) and pandrug-resistant (PDR). This study describes the incidence of Gram-negative MDR, XDR and PDR in 12 private and adult intensive care units (ICU’s) from Belo Horizonte, Minas Gerais, the sixth most populated city in Brazil, with approximately 3 million inhabitants. Methods Data were collected between January/2013 to December/2017 from 12 ICU’s. The hospit

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Karampatakis, Theodoros. "Molecular Characterization of Gram-Negative Bacteria: Antimicrobial Resistance, Virulence and Epidemiology." Antibiotics 13, no. 5 (2024): 402. http://dx.doi.org/10.3390/antibiotics13050402.

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Begum, Nurjahan, and S. M. Shamsuzzaman. "Emergence of multidrug resistant and extensively drug resistant community acquired uropathogens in Dhaka city, Bangladesh." Bangladesh Journal of Medical Microbiology 9, no. 2 (2017): 7–12. http://dx.doi.org/10.3329/bjmm.v9i2.31414.

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Because of indiscriminate, inadequate and irrational usage of antimicriobials, the sensitivity pattern of community acquired uropathogens is changing drastically, specifically in developing countries, such as Bangladesh. This study was undertaken to investigate the profile of common uropathogens in community settings and to evaluate their antimicrobial resistance profile in order to categorize them into multidrug resistant (MDR), extensively drug resistant (XDR) and pandrug resistant (PDR) organisms.Total 800 urine samples were collected from symptomatic UTI cases and processed in the Departme

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Hogea, Elena, Alexandra-Cristina Muntean, Oana Plavitu, et al. "Six-Year Epidemiologic Analysis of Antibiotic Resistance Patterns of Klebsiella pneumoniae Infections in a Tertiary Healthcare Center in Western Romania." Microbiology Research 15, no. 4 (2024): 2661–72. https://doi.org/10.3390/microbiolres15040176.

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Background and Objectives: Klebsiella pneumoniae is a major nosocomial pathogen with a remarkable ability to develop resistance to multiple antibiotics, posing significant treatment challenges. This study aims to evaluate the antimicrobial resistance patterns among multidrug-resistant (MDR) and non-MDR strains of K. pneumoniae isolated over a six-year period (2018–2023) at the Clinical Hospital of Infectious Diseases and Pulmonology “Dr. Victor Babes” in Timisoara, Romania. The objectives include categorizing isolates based on their antibiotic resistance profiles and identifying trends in resi

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Behlul, Rawaa, Emad Saqiq Ali, Raad Abdulameer Alasady, et al. "Survey Study of Multidrug-Resistant, Extensively Drug-Resistant and Pan drug-Resistant Bacteria: Different Clinical Isolates from Hospitals in Najaf City, Iraq." Azerbaijan Pharmaceutical and Pharmacotherapy J 22, no. 1 (2022): 70–74. http://dx.doi.org/10.61336/appj/22-1-15.

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Morbidity and mortality rates due to antimicrobial resistance have been increasing worldwide as a result of the inappropriate use of antimicrobial agents. Hence, understanding and increasing the data about antimicrobial resistance in clinical settings help reduce the risk of resistance and treat patients with more selective antimicrobial agents. Aim: This study aims to examine the clinical isolates that are resistant to nearly all categories of antimicrobials and investigate the frequency of multidrug-resistant (MDR), extensively drug-resistant (XDR), and pan drug-resistant (PDR) bacteria in h

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Pattnaik, Dipti, Subhra Snigdha Panda, Nipa Singh, Smrutilata Sahoo, Ipsa Mohapatra, and Jagadananda Jena. "Multidrug resistant, extensively drug resistant and pan drug resistant gram negative bacteria at a tertiary care centre in Bhubaneswar." International Journal Of Community Medicine And Public Health 6, no. 2 (2019): 567. http://dx.doi.org/10.18203/2394-6040.ijcmph20190170.

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Background: Multidrug resistance has emerged as a challenge in health care settings. Again increasing prevalence of multidrug resistant (MDR), extensively drug resistant (XDR) and pan drug resistant (PDR) gram negative bacteria is making the condition more critical because of limited options of antibiotics, increasing morbidity, mortality and hospital stay of the patients. The present study is carried out with an aim to estimate the prevalence of MDR, XDR, PDR gram negative bacteria in a tertiary care hospital.Methods: Total of 912 gram negative bacterial isolates obtained from various samples

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Alnour, Tarig M. S., Eltayib H. Ahmed-Abakur, Elmutuz H. Elssaig, Faisel M. Abuduhier, and Mohammad Fahad Ullah. "Antimicrobial synergistic effects of dietary flavonoids rutin and quercetin in combination with antibiotics gentamicin and ceftriaxone against E. coli (MDR) and P. mirabilis (XDR) strains isolated from human infections: Implications for food–medicine interactions." Italian Journal of Food Science 34, no. 2 (2022): 34–42. http://dx.doi.org/10.15586/ijfs.v34i2.2196.

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Antimicrobial resistance has emerged as a major global concern for public health in the last two decades, which tends to compromise the existing drug regimens in treating common or severe infections. According to WHO, three million laboratory-confirmed bacterial infections have been reported from 70 countries in 2019, caused by pathogens of concern. The drug-resistant bacterial strains are characterized as multidrug-resistant (MDR), extensively drug-resistant (XDR), and pan drug-resistant (PDR) based on the different patterns of resistance. It is believed that novel strategies are essentially

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Alnour, Tarig M. S., Eltayib H. Ahmed-Abakur, Elmutuz H. Elssaig, Faisel M. Abuduhier, and Mohammad Fahad Ullah. "Antimicrobial synergistic effects of dietary flavonoids rutin and quercetin in combination with antibiotics gentamicin and ceftriaxone against E. coli (MDR) and P. mirabilis (XDR) strains isolated from human infections: Implications for food–medicine interactions." Italian Journal of Food Science 34, no. 2 (2022): 34–42. http://dx.doi.org/10.15586/ijfs.v34i2.2196.

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Antimicrobial resistance has emerged as a major global concern for public health in the last two decades, which tends to compromise the existing drug regimens in treating common or severe infections. According to WHO, three million laboratory-confirmed bacterial infections have been reported from 70 countries in 2019, caused by pathogens of concern. The drug-resistant bacterial strains are characterized as multidrug-resistant (MDR), extensively drug-resistant (XDR), and pan drug-resistant (PDR) based on the different patterns of resistance. It is believed that novel strategies are essentially

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Addis, Tesfa, Yonas Mekonnen, Zeleke Ayenew, Surafel Fentaw, and Habtamu Biazin. "Bacterial uropathogens and burden of antimicrobial resistance pattern in urine specimens referred to Ethiopian Public Health Institute." PLOS ONE 16, no. 11 (2021): e0259602. http://dx.doi.org/10.1371/journal.pone.0259602.

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Background Urinary tract infections (UTIs) are the leading causes of morbidity in the general population, and is the second most common infectious disease after respiratory infections. Appropriate antibiotic therapy is essential to achieving good therapeutic results. Therefore, the purpose of this study was to investigate the profile of pathogens cultured from urinary tract infections and to determine their resistance profiles to commonly prescribed antibiotics. Method A cross-sectional study was carried out at the National Referral Laboratory of the Ethiopian Institute of Public Health from J

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Pérez, Astrid, Eva Gato, José Pérez-Llarena, et al. "High incidence of MDR and XDR Pseudomonas aeruginosa isolates obtained from patients with ventilator-associated pneumonia in Greece, Italy and Spain as part of the MagicBullet clinical trial." Journal of Antimicrobial Chemotherapy 74, no. 5 (2019): 1244–52. http://dx.doi.org/10.1093/jac/dkz030.

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Abstract Objectives To characterize the antimicrobial susceptibility, molecular epidemiology and carbapenem resistance mechanisms in Pseudomonas aeruginosa isolates recovered from respiratory tract samples from patients with ventilator-associated pneumonia enrolled in the MagicBullet clinical trial. Methods Isolates were collected from 53 patients from 12 hospitals in Spain, Italy and Greece. Susceptibility was determined using broth microdilution and Etest. MALDI-TOF MS was used to detect carbapenemase activity and carbapenemases were identified by PCR and sequencing. Molecular epidemiology w

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Waske, Dr Sonali, та Dr Yogyata Marothi. "A Clinico-Microbiological Study of Β-Lactamase Producing Klebsiella Pneumoniae Among Neonates From Neonatal Intensive Care Unit At Tertiary Care Hospital, Ujjain". Middle East Research Journal Microbiology and Biotechnology 1, № 1 (2021): 18–24. http://dx.doi.org/10.36348/merjmb.2021.v01i01.005.

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Abstract: Infection caused by drug resistance Klebsiella pneumoniae is very common now days in community as well as nosocomial environment. K.pneumoniae is second most common pathogen in neonatal septicemia. Our aim to detect drug resistance K.pneumoniae by production of β-lactamase enzymes such as extended spectrum β-lactamase (ESBL), AmpC β-lactamase, metalo β-lactamase (MBL) and carbapenemase in neonatal septicemia. A total 13 isolates of K.pneumoniae detected from neonates admitted in tertiary care centre during study period from February 2015 to July 2016. We analyzed risk factors in K. p

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Mohamed, Amira, Enas Daef, Amany Nafie, Lamia Shaban, and Maggie Ibrahim. "Characteristics of Carbapenem-Resistant Gram-Negative Bacilli in Patients with Ventilator-Associated Pneumonia." Antibiotics 10, no. 11 (2021): 1325. http://dx.doi.org/10.3390/antibiotics10111325.

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Carbapenem-resistant Gram-negative bacilli (CR-GNB) has become a global threat. In hospital settings, the association of CR-GNB with ventilator-associated pneumonia (VAP) is a critical public health concern owing to their high resistance rate to most antibiotics. The present study aims to identify the frequency of carbapenem-resistance and to determine the rate of multidrug resistance (MDR), extensive drug resistance (XDR) and pan-drug resistance (PDR) among CR-GNB infections in VAP. Antimicrobial susceptibility testing was carried out using the disk diffusion method and the detection of carba

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Patel, Bhavikakumari, Narayana Kamath, and Ranga Reddy Burri. "STUDY ON EMERGENCE OF MDR PATHOGEN AND ITS MICROBIOLOGICAL STUDY." International Journal of Advanced Research 11, no. 06 (2023): 876–84. http://dx.doi.org/10.21474/ijar01/17139.

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Antimicrobial resistance is now a major challenge to clinicians for treating patients.Hence, this study was undertaken to detect the incidence of multidrug-resistant (MDR),extensively drug-resistant (XDR) and pandrug-resistant (PDR) bacterial isolates in a tertiary care hospital. Aims and Objectives: This study was undertaken to detect the incidence of MDR, XDR and PDR bacterial isolates in a tertiary care hospital and to help in antibiotic policy of a hospital to guide the clinicians for empirical usage of antibiotics and prevent drug resistance. Methodology: This research study was conducted

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Farrell, David J., Robert K. Flamm, Helio S. Sader, and Ronald N. Jones. "Antimicrobial Activity of Ceftolozane-Tazobactam Tested against Enterobacteriaceae and Pseudomonas aeruginosa with Various Resistance Patterns Isolated in U.S. Hospitals (2011-2012)." Antimicrobial Agents and Chemotherapy 57, no. 12 (2013): 6305–10. http://dx.doi.org/10.1128/aac.01802-13.

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ABSTRACTCeftolozane/tazobactam, a novel antimicrobial agent with activity againstPseudomonas aeruginosa(including drug-resistant strains) and other common Gram-negative pathogens (including most extended-spectrum-β-lactamase [ESBL]-producingEnterobacteriaceaestrains), and comparator agents were susceptibility tested by a reference broth microdilution method against 7,071Enterobacteriaceaeand 1,971P. aeruginosaisolates. Isolates were collected consecutively from patients in 32 medical centers across the United States during 2011 to 2012. Overall, 15.7% and 8.9% ofP. aeruginosaisolates were clas

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Ndukwu, Chidi L. C., and Nedie P. Akani. "Multidrug Resistance in Klebsiella species Isolated from Liquid Herbal Remedies in Port Harcourt, Nigeria." International Journal of Pathogen Research 12, no. 6 (2023): 83–91. http://dx.doi.org/10.9734/ijpr/2023/v12i6256.

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Aims: Klebsiella are lactose fermenting, encapsulated, non-motile, oxidase-negative, gram negative rods; belonging to the family Enterobacteriaceae and the non-taxonomic group, coliforms. Klebsiella isolates numbering 109, recovered from three categories of liquid herbal medicines were analyzed with the intent of ascertaining the prevalence of multidrug resistance (MDR) strains. Study Design: The research is an observational, descriptive, prospective and cross-sectional research. The samples of herbal remedies procured from randomly selected outlets within Port Harcourt metropolis in a c

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Corona, Alberto, Vincenzo De Santis, Andrea Agarossi, et al. "Antibiotic Therapy Strategies for Treating Gram-Negative Severe Infections in the Critically Ill: A Narrative Review." Antibiotics 12, no. 8 (2023): 1262. http://dx.doi.org/10.3390/antibiotics12081262.

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Introduction: Not enough data exist to inform the optimal duration and type of antimicrobial therapy against GN infections in critically ill patients. Methods: Narrative review based on a literature search through PubMed and Cochrane using the following keywords: “multi-drug resistant (MDR)”, “extensively drug resistant (XDR)”, “pan-drug-resistant (PDR)”, “difficult-to-treat (DTR) Gram-negative infection,” “antibiotic duration therapy”, “antibiotic combination therapy” “antibiotic monotherapy” “Gram-negative bacteremia”, “Gram-negative pneumonia”, and “Gram-negative intra-abdominal infection”.

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Maduakor, Uzoamaka, Clara Eleazar, Chidozie Nwafor, and Veronica Emenuga. "Antibiogram of Pseudomonas aeruginosa Clinical Isolates Tested for Pan, Extensive and Multidrug Resistances." Microbiology Research Journal International 33, no. 11-12 (2023): 14–21. http://dx.doi.org/10.9734/mrji/2023/v33i11-121413.

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Background: Pseudomonas aeruginosa usually cause nosocomial infections with concurrent morbidity and mortality and is generally resistant to many antibiotics. Aim: This study was aimed to determine the proportion of pan-drug-resistant (PDR), extensively drug-resistant (XDR), and multidrug-resistant (MDR) P. aeruginosa strains recovered from human samples. Methodology: The retrospective study was conducted in the University of Nigeria Teaching Hospital Enugu in 2023. Clinical samples obtained from patients between October 2022 and April 2023 were analysed. A total of 100 Pseudomonas

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Abd El-Aziz, Norhan K., Ahmed M. Ammar, Mona M. Hamdy, Adil A. Gobouri, Ehab Azab та Alaa H. Sewid. "First Report of aacC5-aadA7Δ4 Gene Cassette Array and Phage Tail Tape Measure Protein on Class 1 Integrons of Campylobacter Species Isolated from Animal and Human Sources in Egypt". Animals 10, № 11 (2020): 2067. http://dx.doi.org/10.3390/ani10112067.

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Campylobacter species are common commensals in the gastrointestinal tract of livestock animals; thus, animal-to-human transmission occurs frequently. We investigated for the first time, class 1 integrons and associated gene cassettes among pan drug-resistant (PDR), extensively drug-resistant (XDR), and multidrug-resistant (MDR) Campylobacter species isolated from livestock animals and humans in Egypt. Campylobacter species were detected in 58.11% of the analyzed chicken samples represented as 67.53% Campylobacter jejuni(C. jejuni) and 32.47% Campylobacter coli (C. coli). C. jejuni isolates wer

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Vulcanescu, Dan Dumitru, Iulia Cristina Bagiu, Tiberiu Liviu Dragomir, et al. "The Impact of the COVID-19 Pandemic on Pediatric Microbial Resistance Patterns and Abandonment Rates in Western Romania—An Interdisciplinary Study." Antibiotics 14, no. 4 (2025): 411. https://doi.org/10.3390/antibiotics14040411.

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Background: The COVID-19 pandemic in Romania exacerbated pediatric antimicrobial resistance (AMR). Overuse of broad-spectrum antibiotics may be related to increased multidrug-resistant bacteria. The main aim of this study was to assess pediatric AMR trends and phenotypes, while a secondary objective was to investigate the potential links with hospital abandonment. Methods: This retrospective study from the Children’s Emergency Hospital “Louis Țurcanu”, Timișoara, focused on AMR patterns in 2019 pre-pandemic, 2021 pandemic, and 2023 post-pandemic. The following phenotypes were assessed: MRSA, M

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Bozhkova, S. A., E. M. Gordina, O. V. Schneider, A. N. Rukina, and V. V. Shabanova. "Resistance of carbapenemase-producing Klebsiella pneumoniae isolated from patients with orthopedic infection." Clinical Microbiology and Antimicrobial Chemotherapy 22, no. 1 (2020): 47–52. http://dx.doi.org/10.36488/cmac.2020.1.47-52.

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Objective. To evaluate the resistance rate and production of carbapenemases in Klebsiella pneumoniae with phenotypic resistance to carbapenems isolated from patients with orthopedic infection. Materials and Methods. The materials for the study were tissue samples, aspirates and removed orthopedic devices of patients with orthopedic infection at the Vreden Russian Research Institute of Traumatology and Orthopedics, between 2017 and 2019. K. pneumoniae strains were identified in Microlatest by iEMS ReaderMF. These strains were tested for susceptibility to 15 antimicrobial agents by disk diffusio

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Haji, Sayran Hamad, Safaa Toma Hanna Aka, and Fattma A. Ali. "Prevalence and characterisation of carbapenemase encoding genes in multidrug-resistant Gram-negative bacilli." PLOS ONE 16, no. 11 (2021): e0259005. http://dx.doi.org/10.1371/journal.pone.0259005.

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Background Emerging worldwide in the past decade, there has been a significant increase in multidrug-resistant bacteria from serious nosocomial infections, especially carbapenemase-producing Gram-negative bacilli that have emerged worldwide. The objective of this study is to investigate carbapenem resistance in Gram-negative bacilli bacteria using phenotypic detection, antimicrobial resistance profiles and genotypic characterisation methods. Methods 200 Gram-negative bacilli isolates were collected from different clinical specimens. All clinical samples were exposed to isolation and identifica

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Moglad, Ehssan H. "Antibiotics Profile, Prevalence of Extended-Spectrum Beta-Lactamase (ESBL), and Multidrug-Resistant Enterobacteriaceae from Different Clinical Samples in Khartoum State, Sudan." International Journal of Microbiology 2020 (October 24, 2020): 1–6. http://dx.doi.org/10.1155/2020/8898430.

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One of the global requirements for controlling the occurrence of resistance to antimicrobial drugs is to understanding the resistivity profile of various clinical isolates. Therefore, this study aimed to deliver the indication of different resistant profiles of clinically isolated Enterobacteriaceae from different sources of samples from Khartoum state, Sudan, and to determine the prevalence rate of extended-spectrum beta-lactamase (ESBL), multidrug-resistant (MDR), extensively drug-resistant (XDR), and pandrug-resistant (PDR) bacteria. A total of 144 Gram-negative bacteria were collected from

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Schimmenti, A., E. Brunetti, E. Seminari, B. Mariani, P. Cambieri, and P. Orsolini. "Prosthetic Joint Infection from Carbapenemase-Resistant Klebsiella pneumoniae Successfully Treated with Ceftazidime-Avibactam." Case Reports in Infectious Diseases 2018 (August 14, 2018): 1–5. http://dx.doi.org/10.1155/2018/1854805.

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Antimicrobial resistance in Gram-negative bacteria, particularly Enterobacteriaceae, has become a leading cause of morbidity and mortality and a serious public health concern. Gram-negative bacteria carrying extended-spectrum beta-lactamase (ESBL) enzymes now represent a significant proportion of all bacteria isolated from different countries worldwide. Furthermore, the increasing number of isolates carrying carbapenemases in recent years includes multidrug-resistant (MDR), extensively drug-resistant (XDR), and pandrug-resistant (PDR) bacteria. Here, we describe what, to our knowledge, is the

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Nolan, Patrick James, Tiffeny Smith, James D. Finklea, Leah Cohen, and Raksha Jain. "1594. Ceftolozane–Tazobactam Demonstrates Higher In Vitro Susceptibility than Ceftazidime–Avibactam Against Pseudomonas aeruginosa Isolated from Respiratory Tract of Adult Cystic Fibrosis Patients." Open Forum Infectious Diseases 6, Supplement_2 (2019): S581—S582. http://dx.doi.org/10.1093/ofid/ofz360.1458.

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Abstract Background Pseudomonas aeruginosa is a commonly isolated pathogen in adults with cystic fibrosis (CF). Antimicrobial resistance is an escalating problem due to chronic colonization and frequent antimicrobial exposure. Ceftolozane–tazobactam (C/T) and ceftazidime–avibactam (CZA) exhibit promising activity against antimicrobial-resistant organisms, including P. aeruginosa. In this study, we compared in vitro activity of C/T and CZA against P. aeruginosa isolated from respiratory cultures obtained from adult patients with CF. Methods This is a retrospective study of respiratory cultures

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Reis, Henry Pablo Lopes Campos e., Ana Beatriz Ferreira Rodrigues, Julio César Castro Silva, et al. "871. Assessment of the Wide-resistant Pseudomonas aeruginosa Outbreak at a University Hospital in Brazil: Have We Lost This War?!" Open Forum Infectious Diseases 7, Supplement_1 (2020): S474. http://dx.doi.org/10.1093/ofid/ofaa439.1060.

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Abstract Background Resistance profile analysis in Pseudomonas aeruginosa isolates is extremely important to prevent its transmission and to detect outbreaks. Broadly resistant strains (BR) have a high mortality rate in invasive infections. By analyzing the clinical and microbiological characteristics of these infections, one can define more effective actions in a nosocomial outbreak setting in a university hospital in Brazil. Methods From January to September 2019, 13 patients from the oncohematology services and intensive care unit (ICU) followed by the stewardship program of a public univer

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Avakh, Asiyeh, Gary D. Grant, Matthew J. Cheesman, Tejaswini Kalkundri, and Susan Hall. "The Art of War with Pseudomonas aeruginosa: Targeting Mex Efflux Pumps Directly to Strategically Enhance Antipseudomonal Drug Efficacy." Antibiotics 12, no. 8 (2023): 1304. http://dx.doi.org/10.3390/antibiotics12081304.

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Pseudomonas aeruginosa (P. aeruginosa) poses a grave clinical challenge due to its multidrug resistance (MDR) phenotype, leading to severe and life-threatening infections. This bacterium exhibits both intrinsic resistance to various antipseudomonal agents and acquired resistance against nearly all available antibiotics, contributing to its MDR phenotype. Multiple mechanisms, including enzyme production, loss of outer membrane proteins, target mutations, and multidrug efflux systems, contribute to its antimicrobial resistance. The clinical importance of addressing MDR in P. aeruginosa is paramo

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E.T., Olaleye, Raheem T.Y., Olowe B.M., Adesina F.C., and Moshood W.K. "Assessment of Microbial Contamination and Antibiotic Resistance Profiles of Bacteria on Nigerian Currency Notes: Implications for Public Health and Antimicrobial Resistance." South Asian Journal of Research in Microbiology 18, no. 12 (2024): 75–84. https://doi.org/10.9734/sajrm/2024/v18i12409.

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Background: Many microbes have been associated with the contamination of Naira notes, and most of these microbes have shown high resistance to antimicrobials, with different resistance profiles including multidrug-resistant (MDR), extensively drug-resistant (XDR), and pandrug-resistant (PDR). Therefore, the aim of this study was to investigate the microbial contamination and antibiotic resistance profiles of isolated microorganisms on Nigerian currency notes, emphasizing their public health implications. Methods: A total of 112 currency notes, spanning all eight denominations, were collected f

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Ramirez, Maria Soledad, Robert A. Bonomo, and Marcelo E. Tolmasky. "Carbapenemases: Transforming Acinetobacter baumannii into a Yet More Dangerous Menace." Biomolecules 10, no. 5 (2020): 720. http://dx.doi.org/10.3390/biom10050720.

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Acinetobacter baumannii is a common cause of serious nosocomial infections. Although community-acquired infections are observed, the vast majority occur in people with preexisting comorbidities. A. baumannii emerged as a problematic pathogen in the 1980s when an increase in virulence, difficulty in treatment due to drug resistance, and opportunities for infection turned it into one of the most important threats to human health. Some of the clinical manifestations of A. baumannii nosocomial infection are pneumonia; bloodstream infections; lower respiratory tract, urinary tract, and wound infect

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Wash, Pari, Asiya Batool, Shah Mulk, et al. "Prevalence of Antimicrobial Resistance and Respective Genes among Bacillus spp., a Versatile Bio-Fungicide." International Journal of Environmental Research and Public Health 19, no. 22 (2022): 14997. http://dx.doi.org/10.3390/ijerph192214997.

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The plant rhizosphere is not only a reservoir of microbes but also a hub of antimicrobial resistance genes. Rhizospheric Bacillus spp. are the potential bio-inoculants with a versatile application in agriculture as bio-fertilizer and bio-fungicide. In the current study, the potential bio-control agent that is the Bacillus species (n = 7) was screened for the antimicrobial resistance pattern to assess their risk before registering them as a bio-inoculant. All of the Bacillus spp. were categorized as multi-drug-resistant (MDR), bacteria but none of them was either pan-drug-resistant (PDR) or ext

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Berdeu, Ion. "Antimicrobial resistance profile of Pseudomonas aeruginosa strains." Public Health, Economy and Management in Medicine, no. 4(101) (October 2024): 63–79. https://doi.org/10.52556/2587-3873.2024.4(101).10.

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Antimicrobial resistance is one of the most serious threats facing humanity today. Th e majority of pathogens on the WHO list with high resistance to antibiotics are Gram-negative bacteria, including Pseudomonas. Data on the etiological structure of septico-purulent infections (SPIs), multiple antibiotic resistance of microorganisms isolated from patients hospitalized at the Institute of Emergency Medicine were analyzed. Gram-positive bacteria accounted for 40,15% among the isolated strains, with a predominance of Enterococcus faecalis, Staphylococcus aureus and Staphylococcus epidermidis spec

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Fayyaz, Muhammad, Hafsa Khalil, Irfan Ali Mirza, Uzma Meral, Humaira Zafar, and Wajid Hussain. "In Vitro Efficacy of Tetracyclines Against Multi Drug Resistant Acinetobacter Baumannii Amongst Intensive Care Patients." Pakistan Armed Forces Medical Journal 72, SUPPL-3 (2022): S663–67. http://dx.doi.org/10.51253/pafmj.v72isuppl-3.9579.

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Objective: To determine the anti-microbial susceptibility and frequency of A.baumannii, especially focusing the efficacy of Doxycycline and Minocycline against multi drug resistant (MDR) and extremely drug resist ant (XDR) A.baumannii in atertiary care hospital. Study Design: It was a descriptive cross sectional study. Place and Duration of Study: Study conducted at the department of Pathology, Armed Forces Institute of Cardiology/National Institute of Heart Diseases (AFIC/NIHD), Rawalpindi Pakistan from Jan 2020 to Dec 2021. Methodology: It was a descriptive cross sectional

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Córdova-Espinoza, María Guadalupe, Silvia Giono-Cerezo, Erika Gabriela Sierra-Atanacio, et al. "Isolation and Identification of Multidrug-Resistant Klebsiella pneumoniae Clones from the Hospital Environment." Pathogens 12, no. 5 (2023): 634. http://dx.doi.org/10.3390/pathogens12050634.

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Global dispersion, hospital outbreaks, and lineage relationships between emerging antibiotic-resistant strains such as Klebsiella pneumoniae are of public health interest. This study aimed to isolate and identify K. pneumoniae clones from third-level healthcare hospitals in Mexico to establish their multidrug-resistant phenotype, phylogeny, and prevalence. Biological and abiotic surface samples were used to isolate K. pneumoniae strains and to test their antibiotic susceptibility to classify them. The housekeeping genes: gapA, InfB, mdh, pgi, phoE, ropB, and tonB were used for multilocus seque

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Amin, Ismail, Adel Abdelkhalek, Azza S. El-Demerdash, Ioan Pet, Mirela Ahmadi, and Norhan K. Abd El-Aziz. "Cellulose Nanocrystal/Zinc Oxide Bio-Nanocomposite Activity on Planktonic and Biofilm Producing Pan Drug-Resistant Clostridium perfringens Isolated from Chickens and Turkeys." Antibiotics 14, no. 6 (2025): 575. https://doi.org/10.3390/antibiotics14060575.

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Background/Objectives: Clostridium perfringens is a normal inhabitant of the intestinal tract of poultry, and it has the potential to induce cholangiohepatitis and necrotic enteritis (NE). The poultry industry suffers significant financial losses because of NE, and treatment becomes more challenging due to resistant C. perfringens strains. Methods: The antimicrobial and antibiofilm activities of cellulose nanocrystals/zinc oxide nanocomposite (CNCs/ZnO) were assesses against pan drug-resistant (PDR) C. perfringens isolated from chickens and turkeys using phenotypic and molecular assays. Result

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Abdelatti, Mohamed A. I., Norhan K. Abd El-Aziz, El-sayed Y. M. El-Naenaeey, et al. "Antibacterial and Anti-Efflux Activities of Cinnamon Essential Oil against Pan and Extensive Drug-Resistant Pseudomonas aeruginosa Isolated from Human and Animal Sources." Antibiotics 12, no. 10 (2023): 1514. http://dx.doi.org/10.3390/antibiotics12101514.

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Pseudomonas aeruginosa is notorious for its ability to develop a high level of resistance to antimicrobial agents. Resistance-nodulation-division (RND) efflux pumps could mediate drug resistance in P. aeruginosa. The present study aimed to evaluate the antibacterial and anti-efflux activities of cinnamon essential oil either alone or combined with ciprofloxacin against drug resistant P. aeruginosa originated from human and animal sources. The results revealed that 73.91% of the examined samples were positive for P. aeruginosa; among them, 77.78% were of human source and 72.73% were recovered f

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Osayi, Eko, Kefas, Ngwai,Yakubu Boyi, Nkene, Istifanus Haruna, Abimiku, Rejoice Helma, and Datok, Danladi Walong. "Antimicrobial Resistance Profile of Uropathogenic Escherichia coli Isolated in Garaku, Keffi and Mararaban-Gurku Healthcentres, Nasarawa-West Senatorial District, Nasarawa State, Nigeria." Journal of Advances in Microbiology 24, no. 4 (2024): 12–24. http://dx.doi.org/10.9734/jamb/2024/v24i4812.

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Aims: This Study is aimed at studying the Antimicrobial Resistance profile of Uropathogenic Escherichia coli isolated in Garaku, Keffi and Mararaban-gurku Healthcentres, Nasarawa-West Senatorial District, Nasarawa State, Nigeria. Study Design: is a survey research. Place and Duration of Study: Department of Microbiology, Nasarawa State University, Keffi, between June, 2021 and January,2024. Methodology: 384 urine samples of patients with suspected cases of UTIs were collected and E. coli was isolated and identified using standard microbiological methods. Antimicrobial Susceptibility Testing of

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Asaduzzaman, Muhammad, Nishat Nasrin, Tania Yeasmin, Sreedam Chandra Das, Sufia Islam, and Mushtaque Ahmed. "Clinical Evidence of Multi-drug Resistant, Extensively Drug Resistant and Pan-drug Resistant Acinetobacter sp. in Bangladesh." Bangladesh Pharmaceutical Journal 27, no. 1 (2024): 67–72. http://dx.doi.org/10.3329/bpj.v27i1.71156.

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Blood borne infections are one of the major health problems in Bangladesh, which requires frequent use of antimicrobials. In most of the cases, diagnosis and treatment with such antimicrobials are done empirically. Therefore, updated information on etiological data for major pathogens and their pattern of antibiotic resistance is required for formulating strategy and guideline for the prescribers. This study was carried out to assess the pattern of antibiotic resistance and to determine the prevalence of resistance phenotypes of different bacterial pathogens, including Acinetobacter sp. previo

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Chadha, A., W. Jamal, and V. O. Rotimi. "Emergence of nosocomial-acquired extensively drug-resistant and pandrug-resistant Enterobacterales in a teaching hospital in Kuwait." African Journal of Clinical and Experimental Microbiology 23, no. 4 (2022): 426–36. http://dx.doi.org/10.4314/ajcem.v23i4.11.

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Background: The emergence and high ascendancy of infections caused by extensively-drug-resistant (XDR) and pandrug-resistant (PDR) Enterobacterales isolates is a serious clinical and public health challenge. Isolation of PDR Gram-negative bacteria (GNB) in clinical setting is very rare and rarer is the infection caused by XDR GNB. Apart from restricted therapeutic options, these infections are associated with increased mortality and morbidity. Urgent studies to re-evaluate existing therapeutic options and research into new antibiotic molecules are desperately needed. The objectives of this stu

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Prasad, Minakshi, Mayukh Ghosh, Rajesh Kumar, et al. "The Importance of Nanomedicine in Prophylactic and Theranostic Intervention of Bacterial Zoonoses and Reverse Zoonoses in the Era of Microbial Resistance." Journal of Nanoscience and Nanotechnology 21, no. 6 (2021): 3404–52. http://dx.doi.org/10.1166/jnn.2021.18999.

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Emergence of multidrug resistance (MDR), extensively drug resistance (XDR) and pandrug resistance (PDR) strains of bacteria in communicable diseases of zoonotic and reverse zoonotic importance is the major hurdle of one health concept. Increasing level of resistance against antibiotics among bacterial population throughout the world, slow pace of new antibacterial drug discovery and enhanced pace of resistance development by pathogenic bacteria possess major challenges for human and animal health as well as life in future. Alternative management strategy in terms of improved prophylactic vacci

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Atea Ajeel, Esraa, and Rana Kadhim Mohammed. "Biofilm Formation of Locales Clinical Multidrug Resistance Klebsiella pneumoniae Isolated from Different Sources deals with Antimicrobial Resistance." Sumer 4 8, CSS 4 (2023): 1–12. http://dx.doi.org/10.21931/rb/css/2023.08.04.54.

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The goal of this study was to detect antibiotic resistance and determine the ability of clinical isolates Klebsiella pneumoniae (K. pneumoniae) to form biofilms and detect the relationship between biofilm formation and antimicrobial resistance that depends on the specimen sources at the localized Baghdad Hospitals. This gram-negative rod bacterium is an opportunistic pathogen that can cause various illnesses in people and animals, such as important respiratory tract infections. For these reasons, our study included 87 isolates of K. pneumoniae from different clinical cases. The number and perc

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Jibril, Abubakar, Mairo Usman Kadaura, Suleiman Farida Gachi, et al. "Multi Drug Resistance, Extensive Drug Resistance, and Pan Drug Resistance Enterobacterales from Clinical Samples in Usmanu Danfodiyo University Teaching Hospital Sokoto." EAS Journal of Parasitology and Infectious Diseases 7, no. 01 (2025): 1–6. https://doi.org/10.36349/easjpid.2025.v07i01.001.

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Antimicrobial resistance (AMR) is now recognized as one of the most serious global threats to human health in the 21st century. This study is set out to investigate the resistance pattern of Enterobacterales from clinical isolates in Usmanu Danfodiyo University Teaching Hospital, Sokoto, Nigeria. Three hundred and twenty isolates of Enterobacterales were isolated from different clinical samples and identified using the Analytical Profile Index 20E. Antimicrobial susceptibility testing was performed using the modified Kirby-Bauer disk diffusion method, and the antibiotics tested include Augment

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Silva, Líllian Oliveira Pereira da, Jaime Antonio Abrantes, and Joseli Maria da Rocha Nogueira. "Antimicrobial Susceptibility Profile of Bacteria Isolated from Raw Sewage at a Wastewater Treatment Plant in Rio de Janeiro." Journal of Advances in Medicine and Medical Research 36, no. 12 (2024): 141–52. https://doi.org/10.9734/jammr/2024/v36i125661.

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Background and Aim: Given the concentration of microorganisms and emerging micropollutants, wastewater is a favorable environment for the exchange of resistance genes and the selection of antimicrobial-resistant strains, one of the most significant global threats of the 21st century, since inadequate environmental sanitation causes around 88% of deaths worldwide. The present study aimed to identify bacteria isolated from a sewage treatment plant located in Rio de Janeiro and determine their susceptibility profile to antimicrobials. Methods: A 10 µL aliquot of raw sewage was inoculated onto chr

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Hafiz, Taghreed A., Eman A. Bin Essa, Sarah R. Alharbi, et al. "Epidemiological, Microbiological, and Clinical Characteristics of Multi-Resistant Pseudomonas aeruginosa Isolates in King Fahad Medical City, Riyadh, Saudi Arabia." Tropical Medicine and Infectious Disease 8, no. 4 (2023): 205. http://dx.doi.org/10.3390/tropicalmed8040205.

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Increasing rates of serious multi-drug resistant (MDR) Pseudomonas aeruginosa infections have been reported globally, including in Saudi Arabia. This retrospective study investigates the epidemiological, microbiological, and clinical characteristics of multi-resistant P. aeruginosa (n3579 clinical isolates) in King Fahad Medical City, Riyadh, Saudi Arabia (2019–2021). Information on antimicrobial susceptibility and medical history was collected from the hospital database. P. aeruginosa infections occurred in 55.6% of males and 44.4% of females, and P. aeruginosa was more prevalent in children

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Nicolosi, Daria, Giulio Petronio Petronio, Stefano Russo, et al. "Innovative Phospholipid Carriers: A Viable Strategy to Counteract Antimicrobial Resistance." International Journal of Molecular Sciences 24, no. 21 (2023): 15934. http://dx.doi.org/10.3390/ijms242115934.

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The overuse and misuse of antibiotics have led to the emergence and spread of multidrug-resistant (MDR), extensively drug-resistant (XDR), and pan-drug-resistant (PDR) bacteria strains, usually associated with poorer patient outcomes and higher costs. In order to preserve the usefulness of these life-saving drugs, it is crucial to use them appropriately, as also recommended by the WHO. Moreover, innovative, safe, and more effective approaches are being investigated, aiming to revise drug treatments to improve their pharmacokinetics and distribution and to reduce the onset of drug resistance. G

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Rojas, Laura J., Mohamad Yasmin, Jacquelynn Benjamino, et al. "1458. Uncharted territories: applying “precision medicine” to understand the treacherous landscape of extensively and multidrug resistant (XDR and MDR) Pseudomonas aeruginosa in a patient with cystic fibrosis and lung transplantation." Open Forum Infectious Diseases 7, Supplement_1 (2020): S731. http://dx.doi.org/10.1093/ofid/ofaa439.1639.

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Abstract Background Pseudomonas aeruginosa is a persistent and difficult-to-treat pathogen in many patients, especially those with cystic fibrosis (CF). Herein, we describe our experience managing a young woman suffering from CF with XDR P. aeruginosa who underwent lung transplantation. We highlight the contemporary difficulties reconciling the clinical, microbiological, and genetic information. Methods Mechanism-based-susceptibility disk diffusion synergy testing with double and triple antibiotic combinations aided in choosing tailored antimicrobial combinations to control the infection in th

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