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Dissertations / Theses on the topic 'MDSC'

Author: Grafiati
Published: 4 June 2021
Last updated: 25 July 2025

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1

Limagne, Emeric. "Implication des cellules myéloïdes immunosuppressives (MDSC) et des lymphocytes TH17 dans l’efficacité des chimiothérapies et de l’immunothérapie." Thesis, Paris Sciences et Lettres (ComUE), 2017. http://www.theses.fr/2017PSLEP004/document.

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L’oncologie actuelle est encore confrontée à la résistance et à la progression rapide des cancers. Les mécanismes de résistance intrinsèque développés par les cellules tumorales peuvent compromettre l’efficacité des chimiothérapies et des immunothérapies. Il est maintenant admis que l’état de la réponse immunitaire de l’hôte détermine en partie l’issue thérapeutique des patients. L’objectif de notre équipe de recherche est donc de caractériser cette réponse et d’étudier l’impact des thérapies conventionnelles sur celle-ci dans le but d’identifier les mécanismes liés à un échappement futur de l
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2

Metzger, Philipp [Verfasser], and Max [Akademischer Betreuer] Schnurr. "Myeloid-derived suppressor cells (MDSC) in murine pancreatic cancer: Role of IRF4 in development and function of MDSC in RIG-I-like helicase-based immunotherapy / Philipp Metzger ; Betreuer: Max Schnurr." München : Universitätsbibliothek der Ludwig-Maximilians-Universität, 2019. http://d-nb.info/1213245826/34.

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3

Mundy-Bosse, Bethany L. "Myeloid-Derived Suppressor Cells in Tumor Immunology." The Ohio State University, 2011. http://rave.ohiolink.edu/etdc/view?acc_num=osu1311261626.

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4

Papalini, Francesca. "Analisi del programma tollerogenico delle cellule soppressorie di origine mieloide." Doctoral thesis, Università degli studi di Padova, 2011. http://hdl.handle.net/11577/3423333.

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SUMMARY Tumor can activate a complex network of negative control of the immune response, inducing immunological tolerance. Antitumor chemotherapy causes immunosuppression but also favours activation of immune effectors by either triggering immunogenic cancer cell death or removing immunosoppressive constraints established in the host by growing tumors. In this work we demonstrated that the antimetabolite 5-fluoruracil can reduce for a long time the number of myeloid derived suppressor cells (MDSCs) residing in the spleen. This chemothrapeutic drug does not affect directly cancer cells but
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5

Assimacopoulos, Evangelia Maria. "Monitoring and Targeting of Myeloid-Derived Suppressor Cells (MDSC) in Different Mouse Cancer Models." Thesis, The University of Arizona, 2014. http://hdl.handle.net/10150/318817.

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6

Lereclus, Emilie. "Origine et rôles des cellules myéloïdes suppressives dans le sepsis." Thesis, Limoges, 2018. http://www.theses.fr/2018LIMO0060/document.

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Les Myeloid-Derived Suppressor Cells (MDSC) sont une population hétérogène de cellules myéloïdes immatures, regroupées en deux sous-populations : les monocytiques-MDSC (M-MDSC) et les polymorphonucléaires-MDSC (PMN-MDSC). Ces cellules ont des capacités immunosuppressives et peuvent exprimer le ligand PD-L1 induisant l’anergie des lymphocytes T qui expriment le marqueur PD-1. Au cours du sepsis, divers bouleversements immunologiques surviennent, et la fonction majeure des MDSC est probablement de réguler l’hyper-inflammation en participant à l’état d’immunodépression rencontré chez les patients
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7

Falisi, Erika. "Caratterizzazione di una sottopopolazione mieloide umana analoga ai promielociti e dotata di attività immunosoppressoria." Doctoral thesis, Università degli studi di Padova, 2011. http://hdl.handle.net/11577/3421993.

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The ability of the immune system to avoid self-reactivity and autoimmune diseases is achieved by central and peripheral tolerance. Immune tolerance is susteined by different population, one of which is represented by myeloid-derived suppressor cells (MDSC). MDSC are a heterogeneous population of cells consisting of myeloid progenitor cells and immature myeloid cells that are able to suppress both adaptative and innate immunity. In pathological conditions, such as cancer, various infectious diseases and autoimmune diseases, the release of soluble factors induce the increase of myelopoiesis and
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8

Schlecker, Eva [Verfasser], and Viktor [Akademischer Betreuer] Umansky. "The role of tumor-infiltrating MDSC subsets in tumor progression / Eva Schlecker ; Betreuer: Viktor Umansky." Heidelberg : Universitätsbibliothek Heidelberg, 2011. http://d-nb.info/1179229649/34.

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9

Wang, Ninghua. "Evidence for the Intermediate Phase in Bulk (K2O)x(GeO2)1-x glasses and its consequences on Electrical and Thermal Properties." University of Cincinnati / OhioLINK, 2007. http://rave.ohiolink.edu/etdc/view?acc_num=ucin1187020710.

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10

Vincent, Julie. "Rôles des cellules myéloïdes suppressives et des infiltrats immunitaires dans le cancer." Phd thesis, Université de Bourgogne, 2013. http://tel.archives-ouvertes.fr/tel-00967901.

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Le système immunitaire joue un double rôle dans le cancer : il peut non seulement supprimer la croissance tumorale en détruisant les cellules cancéreuses, mais aussi promouvoir la progression de la tumeur en sélectionnant les cellules tumorales ou en créant un microenvironnement tumoral immunosuppresseur. Notre idée principale est de développer des stratégies pour mieux comprendre l'immunologie du cancer colique.Au cours de ma thèse, je me suis tout d'abord intéressée à une population du système immunitaire : les MDSC (Myeloïd Derived Suppressor Cells). Nous avons exploré des stratégies pour r
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11

Weber, Rebekka Renate [Verfasser], and Viktor [Akademischer Betreuer] Umansky. "Regulation of CCR5 expression and immunosuppressive phenotype of MDSC in melanoma / Rebekka Renate Weber ; Betreuer: Viktor Umansky." Heidelberg : Universitätsbibliothek Heidelberg, 2020. http://d-nb.info/1203716168/34.

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12

Weber, Rebekka [Verfasser], and Viktor [Akademischer Betreuer] Umansky. "Regulation of CCR5 expression and immunosuppressive phenotype of MDSC in melanoma / Rebekka Renate Weber ; Betreuer: Viktor Umansky." Heidelberg : Universitätsbibliothek Heidelberg, 2020. http://d-nb.info/1203716168/34.

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13

Sherger, Matthew George. "Identification of Myeloid Derived Suppressor Cells in Tumor Bearing Dogs." The Ohio State University, 2012. http://rave.ohiolink.edu/etdc/view?acc_num=osu1337617975.

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14

Lotfi-Emran, Sahar. "Transformation of human mast cells by interferon-gamma and the potential role of myeloid derived suppressor cells in mastocytosis." VCU Scholars Compass, 2014. http://scholarscompass.vcu.edu/etd/4077.

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Mast cells respond to a variety of signals, are associated with both increased inflammation and regulation of the immune response, and are able to interact with a variety of hematopoietic and non-hematopoietic cells. The majority of the work that highlights mast cell pleiotropic abilities has been completed in murine models. Though these models have significantly advanced our understanding of what mast cells can do, they cannot inform us as to what mast cells actually do in human beings. The goal of this dissertation is to assess fully mature, primary human mast cell function beyond the well-d
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15

Solito, Samantha. "Cellule soppressorie di derivazione mieloide: espansione nei pazienti con tumore, induzione in vitro con fattori di crescita ed analisi dei meccanismi molecolari coinvolti nell'immunosoppressione." Doctoral thesis, Università degli studi di Padova, 2010. http://hdl.handle.net/11577/3426978.

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Myeloid-derived suppressor cells (MDSC) are a heterogeneous population of cells that expands during cancer, inflammation and infection and are potent inhibitors of T-cell-mediated antitumor immunity. MDSC accumulate in the blood, lymph nodes and bone marrow and at tumor sites in most patients and experimental animals with cancer and inhibit both adaptative and innate immunity. Expansion, mobilization and activaction of MDSC is driven by tumors-secreted growth factors, and by a profound alteration of myelopoiesis. In cancer patients the nature of MDSC is still poorly defined since evidence e
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16

Blattner, Carolin [Verfasser], and Viktor [Akademischer Betreuer] Umansky. "The Role of CCR5 in the Recruitment of MDSC to the Tumor Microenvironment / Carolin Blattner ; Betreuer: Viktor Umansky." Heidelberg : Universitätsbibliothek Heidelberg, 2016. http://d-nb.info/1180617428/34.

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17

Dumont, Adélie. "L'action ambivalente de l'agent anti-cancéreux 5-Fluorouracile sur les cellules myéloïdes immunosuppressives sous contrôle de l'acide docosahexaénoïque : Rôle de l'inflammasome NLRP3 et de la voie JNK dans la sécrétion de l'IL-1beta." Thesis, Bourgogne Franche-Comté, 2018. http://www.theses.fr/2018UBFCI013/document.

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Selon une étude précédente, une limitation à l'efficacité anticancéreuse du 5-Fluorouracile (5-FU) repose sur la sécrétion d'IL-1β par des cellules myéloïdes immunosuppressives (MDSC). La libération d'IL-1β mature provient de l'activation de NLRP3 induite par le 5- FU et de l’augmentation de l’activité de la caspase-1 dans les MDSC, qui favorise la reprise de la croissance tumorale chez des souris traitées avec 5-FU. L'acide docosahexaénoïque (DHA) appartient à la famille des acides gras oméga-3 et possède des propriétés anticancéreuses et anti-inflammatoires qui pourraient améliorer la chimio
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18

Giallongo, Cesarina. "Immune escape mechanisms in hematological diseades: role of the myeloid derived suppressor cells and tumor microenvironment." Doctoral thesis, Università di Catania, 2017. http://hdl.handle.net/10761/3889.

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The interactions between the immune system and the tumor cells occur through complex events that lead to tumor eradication or immune evasion by cancer. Recently, the prognostic role of Myeloid derived suppressor cells (MDSC) accumulation has been documented for some hematological malignancies where they correlates with disease progression and persistence of minimal residual disease. We first evaluated the change of MDSC frequency in hematological patients during therapy founding a significant correlation between the number of persistent monocytic-MDSC and major molecular response (MMR) value i
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19

Spieles, Helen [Verfasser], and Christian [Akademischer Betreuer] Gille. "Der postpartal steigende Sauerstoffpartialdruck hemmt myeloide Supressorzellen (MDSC) und reguliert die Immunadaptation des Neugeborenen / Helen Spieles ; Betreuer: Christian Gille." Tübingen : Universitätsbibliothek Tübingen, 2019. http://d-nb.info/1200916727/34.

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20

Dietz, Stefanie [Verfasser]. "Die Bedeutung von HLA-G/Qa2 für die MDSC-Akkumulation während der Schwangerschaft und für den Schwangerschaftserfolg / Stefanie Dietz." Tübingen : Universitätsbibliothek Tübingen, 2021. http://d-nb.info/1241537135/34.

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21

Dash, Shreeram J. "Aging of Selenium glass probed by MDSC and Raman Scattering Experiments: Growth of inter-chain structural correlations leading to network compaction." University of Cincinnati / OhioLINK, 2017. http://rave.ohiolink.edu/etdc/view?acc_num=ucin1490354472387536.

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22

Snell, Andrew John Roger. "Application of Differential Scanning Calorimetry to Characterize Thin Film Deposition Processes." Cleveland State University / OhioLINK, 2010. http://rave.ohiolink.edu/etdc/view?acc_num=csu1280943337.

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23

Bhosle, Siddhesh V. "Direct evidence for abrupt rigidity and stress transitions in dry and homogeneous bulk GexSe100-x glasses." University of Cincinnati / OhioLINK, 2011. http://rave.ohiolink.edu/etdc/view?acc_num=ucin1307106143.

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24

Holokai, Loryn. "Organoid Models of Digestive Diseases." University of Cincinnati / OhioLINK, 2019. http://rave.ohiolink.edu/etdc/view?acc_num=ucin1563437019338307.

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25

Basu, Debasmita. "EX VIVO EXPANSION OF TUMOR-SPECIFIC T CELLS WITH SEQUENTIAL COMMON GAMMA CHAIN CYTOKINES RENDER THEM REFRACTORY TO MDSC UPON ADOPTIVE IMMUNOTHERAPY." VCU Scholars Compass, 2010. http://scholarscompass.vcu.edu/etd/2198.

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Myeloid derived suppressor cells (MDSCs) are heterogeneous population of immature cells at various stages of differentiation, characterized by the presence of CD11b and Gr1 in mice. They are major contributors of the tumor-induced immune suppression against the tumors. So far, various strategies have been introduced to overcome the endogenous MDSCs. Most of these approaches rely on the elimination of MDSCs and it is not clear whether tumor-reactive T cells may be differentiated towards phenotypes that are refractory to MDSCc. Our laboratory has previously shown that high affinity T cells der
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26

Inamoto, Susumu. "Loss of SMAD4 Promotes Colorectal Cancer Progression by Accumulation of Myeloid-Derived Suppressor Cells through CCL15-CCR1 Chemokine Axis." Kyoto University, 2016. http://hdl.handle.net/2433/215386.

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27

Centuori, Sara Mozelle. "NEGATIVE REGULATION OF REGULATORY T CELLS BY MYELOID-DERIVED SUPPRESSOR CELLS IN CANCER." Diss., The University of Arizona, 2011. http://hdl.handle.net/10150/145099.

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Myeloid-derived suppressor cells (MDSC) and regulatory T cells (Treg) play an essential role in the immunosuppressive networks that contribute to tumor immune evasion. The mechanisms by which tumors promote the expansion and/or function of these suppressive cells and the cross-regulation between MDSC and Treg remain incompletely defined. The current work evaluates the influence of MDSC, expanded in two mouse cancer models, on immunosuppressive Treg. We demonstrate that tumor-induced MDSC endowed with the potential of suppressing conventional T lymphocytes surprisingly impair TGF-β1-mediated ge
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28

Telatin, Valentina. "Immunological restoration in chronic HCV-infected patients treated with different antiviral therapies." Doctoral thesis, Università degli studi di Padova, 2018. http://hdl.handle.net/11577/3423262.

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SUMMARY OF THE STUDY The World Health Organization (WHO) estimates that approximately 3% of the global population is chronically infected with Hepatitis C Virus (HCV) and that approximately 3-4 million new cases of hepatitis C occur each year worldwide. While African countries have the highest prevalence of HCV infection (up to 26%) in the world, however, HCV infection represents a global health challenge from which no country, rich or poor, is spared. The acute phase of HCV infection is asymptomatic in the majority of infected individuals (75-80%), and except few cases of acute hepatitis C
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29

Zilio, Serena. "Role of Arginase 1 and Nitric Oxide Synthase 2 as enzymatic mediators of the immunosuppressive activity in tumor-infiltrating myeloid derived suppressor cells." Doctoral thesis, Università degli studi di Padova, 2012. http://hdl.handle.net/11577/3422192.

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MDSCs (myeloid derived suppressor cells) are one of the most important immunoregulatory populations involved in the generation of a permissive environment allowing tumor escape, progression and spreading. In physiologic conditions MDSCs protect the organism from exacerbated immune responses in order to protect surrounding tissues from damage. During tumor growth, cancer cells produce TDSFs (tumor derived soluble factors), which induce MDSC accumulation and their acquisition of a persistent suppressive activity. Among the several mechanisms exploited by MDSCs to exert their suppressive function
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30

Ryan, Nathan M. "Macrophage Migration Inhibitory Factor and Myeloid Derived Suppressor Cell Function in Oral Carcinogenesis." The Ohio State University, 2021. http://rave.ohiolink.edu/etdc/view?acc_num=osu1618413341944817.

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31

Kugel, Hellen Anna [Verfasser], and Christian [Akademischer Betreuer] Gille. "Untersuchungen zur Expression von Myeloiden Suppressorzellen (MDSC) in der humanen Schwangerschaft und ihre Bedeutung für die materno-fetale Toleranz / Hellen Anna Kugel ; Betreuer: Christian Gille." Tübingen : Universitätsbibliothek Tübingen, 2018. http://d-nb.info/1196700745/34.

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32

Kugel, Hellen [Verfasser], and Christian [Akademischer Betreuer] Gille. "Untersuchungen zur Expression von Myeloiden Suppressorzellen (MDSC) in der humanen Schwangerschaft und ihre Bedeutung für die materno-fetale Toleranz / Hellen Anna Kugel ; Betreuer: Christian Gille." Tübingen : Universitätsbibliothek Tübingen, 2018. http://d-nb.info/1196700745/34.

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33

Chakravarty, Soumendu. "Correlating Melt Dynamics and Configurational Entropy Change with Topological Phases of AsxS100-x Glasses and the Crucial Role of Melt/Glass Homogenization." University of Cincinnati / OhioLINK, 2021. http://rave.ohiolink.edu/etdc/view?acc_num=ucin1623241710778164.

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34

Ortiz, Myrna Lillian. "Immature Myeloid Cells Promote Tumor Formation Via Non-Suppressive Mechanism." Scholar Commons, 2014. https://scholarcommons.usf.edu/etd/5089.

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ABSTRACT Although there is ample evidence linking chronic inflammation with cancer, the cellular mechanisms involved in early events leading to tumor development remain unclear. Myeloid cells are an intricate part of inflammation. They consist of mature cells represented by macrophages, dendritic cells and granulocytes and a population of Immature Myeloid Cells (IMC), which in healthy individuals are cells in transition to mature cells. There is a substantial expansion of IMC in cancer and many other pathological conditions which is associated with pathologic activation of these cells. As a re
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35

Siddans, Bradley. "Epoxy/Clay Nanocomposites: Effect of Clay and Resin Chemistry on Cure and Properties." Thesis, Queensland University of Technology, 2005. https://eprints.qut.edu.au/16024/1/Bradley_Siddans_Thesis.pdf.

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Polymer/clay nanocomposites consisting of an epoxy resin matrix filled with organoclays have been investigated. The main objective of this study was to determine which combination of components led to the greatest enhancement in properties of the epoxy resin. Exfoliation of the clay was desired, as exfoliated nanocomposites are known to exhibit great improvements in mechanical properties [1]. The epoxy resins studied were di-functional DGEBA and tetra-functional TGDDM. The epoxy resin was cured with three different hardeners, these included: the high functionality amine hardener, TETA, a
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Siddans, Bradley. "Epoxy/Clay Nanocomposites: Effect of Clay and Resin Chemistry on Cure and Properties." Queensland University of Technology, 2005. http://eprints.qut.edu.au/16024/.

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Polymer/clay nanocomposites consisting of an epoxy resin matrix filled with organoclays have been investigated. The main objective of this study was to determine which combination of components led to the greatest enhancement in properties of the epoxy resin. Exfoliation of the clay was desired, as exfoliated nanocomposites are known to exhibit great improvements in mechanical properties [1]. The epoxy resins studied were di-functional DGEBA and tetra-functional TGDDM. The epoxy resin was cured with three different hardeners, these included: the high functionality amine hardener, TETA, a
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37

Pöhlmann, Milena. "Thermisch härtende Polymerverbundmaterialien als Basis für neue Befestigungssysteme." Doctoral thesis, Saechsische Landesbibliothek- Staats- und Universitaetsbibliothek Dresden, 2006. http://nbn-resolving.de/urn:nbn:de:swb:14-1165492370619-99312.

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Mit der Entwicklung und Einführung ökologischer Bauweise im Neubau sowie neuen Baustoffsystemen in Sandwichbauweise wird es zunehmend erforderlich, neue effektive Befestigungsvarianten zu entwickeln, die eine dauerhafte Fixierung auch unter sicherheitstechnischen Bestimmungen sowie aus Garantie- bzw. haftungsrechtlichen Gründen ermöglichen. Die aus der Praxis bisher bekannten chemischen Befestigungssysteme (Zweikomponentenverbundmörtel, Verbundankerpatronen) weisen hinsichtlich der Applikation unter bautechnischen Bedingungen noch einige Nachteile auf. Dazu gehören vor allem längere Aushärtung
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38

Dajon, Marion. "Rôle de TLR7 dans la progression tumorale dans le cancer du poumon." Thesis, Paris 6, 2017. http://www.theses.fr/2017PA066272/document.

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De nombreuses études ont impliqué des TLR dans le développement et la progression tumorale. Précédemment, il a été démontré que les cellules tumorales expriment TLR7, un récepteur à ARNsb, et qu’une forte expression de TLR7 par les cellules tumorales de patients atteints de cancer du poumon est associée à un mauvais pronostic. Dans un modèle murin de cancer du poumon, cet effet pro-tumoral a été reproduit lors de l’injection d’agoniste de TLR7. Mes travaux de thèse ont eu pour objectif de déterminer les mécanismes impliqués dans les effets pro-tumoraux de TLR7. La stimulation de ce récepteur a
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39

Martin, Rebecca. "The Role of ADAM10 in the Immune System: Maintenance of Lymphoid Architecture, MDSC Development and Function, B cell Derived Exosomal Antigen Presentation, and B1 cell IgE Production." VCU Scholars Compass, 2014. http://scholarscompass.vcu.edu/etd/588.

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ADAM10 is a zinc-dependent metalloprotease. ADAM10 has emerged as a key regulator of cellular processes by cleaving and shedding extracellular domains of multiple transmembrane receptors and ligands. In this study, we examined the role of ADAM10 in the immune system. Here, we show that knocking out ADAM10 on the mature B2 cell causes a defect in the development of secondary lymphoid architecture that becomes more severe post-immunization. We also show that overexpression of ADAM10 leads to a defect in hematopoiesis, which eliminates B2 lymphocyte development. This defect additionally indu
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Fornasari, Benoît Chérel Yan Rouger Karl. "Les cellules souches dérivées du muscle (MDSC) isolement dans deux modèles gros animaux et évaluation comme candidates à la thérapie de la Dystrophie Musculaire de Duchenne (DMD) /." [S.l.] : [s.n.], 2008. http://castore.univ-nantes.fr/castore/GetOAIRef?idDoc=50816.

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Fornasari, Benoît. "Les cellules souches dérivées du muscle (MDSC) : isolement dans deux modèles gros animaux et évaluation comme candidates à la thérapie de la Dystrophie Musculaire de Duchenne (DMD)." Nantes, 2008. https://archive.bu.univ-nantes.fr/pollux/show/show?id=3d5cd2fe-7068-4cd9-8e37-7618e6017684.

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Les approches thérapeutiques de la DMD basées sur la transplantation de myoblastes se sont heurtées à un faible taux de survie cellulaire et une dispersion limitée des cellules. L'identification de cellules souches au sein de tissus adultes et la définition de leur potentiel myogénique ont ouvert de nouvelles perspectives. Dans un 1er temps, nous avons utilisé les propriétés d'adhérence des cellules dérivées du muscle afin d'isoler dans un modèle aviaire des cellules progénitrices résidantes du muscle distinctes des myoblastes, les LAC (late adherent cells). En utilisant la technique de prépla
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42

Arenz, Lukas Philipp [Verfasser], and Rika [Akademischer Betreuer] Draenert. "Die Rolle von Interleukin-10 für den Wirkmechanismus von monozytären myeloid-derived suppressor cells (M-MDSC) in der chronischen HIV-1 Infektion / Lukas Philipp Arenz ; Betreuer: Rika Draenert." München : Universitätsbibliothek der Ludwig-Maximilians-Universität, 2019. http://d-nb.info/1196529108/34.

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Plagge, Julia [Verfasser], and Rika [Akademischer Betreuer] Draenert. "Untersuchung der Bedeutung von Interleukin-10 für den Wirkmechanismus von polymorphonuclear Myeloid-derived suppressor cells (PMN-MDSC) in der chronischen HIV-1 Infektion / Julia Plagge ; Betreuer: Rika Draenert." München : Universitätsbibliothek der Ludwig-Maximilians-Universität, 2018. http://d-nb.info/1163949043/34.

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44

Saleem, Sheinei. "ADAM10 overexpression dysregulates Notch signaling in favor of myeloid derived suppressor cell (MDSC) accumulation that deferentially modulates the host response depending on immune stimuli and interaction with mast cells." VCU Scholars Compass, 2013. http://scholarscompass.vcu.edu/etd/3196.

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Although the physiological consequences of Notch signaling in hematopoiesis have been extensively studied, the differential effects of individual notch cleavage products remain to be elucidated. Given that a disintegrin and metalloproteinase 10 (ADAM10) is a critical regulator of Notch and that its deletion is embryonically lethal, we generated transgenic mice that overexpress ADAM10 at early stages of lymphoid and myeloid development (A10Tg). ADAM10 transgene expression alters hematopoiesis post-hematopoietic Lineage-Sca-1+c-kit+ (LSK) subset differentiation but prior to lineage commitment of
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45

Spehner, Laurie. "Caractérisation des réponses immunitaires périphériques des cancers épithéliaux exprimant les papillomavirus humains." Thesis, Bourgogne Franche-Comté, 2019. http://www.theses.fr/2019UBFCE011.

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L’augmentation de l’incidence et l’absence de ressources thérapeutiques pour les formes non opérables de patients atteints d’un cancer HPV+ est un enjeu important. La forte immunosurveillance au sein des tumeurs associées aux HPV ainsi que la présence d’antigènes viraux associée à l’oncogenèse de ces cancers devraient privilégier le développement de stratégies d’immunothérapies comme la vaccination anti tumorale ainsi que le transfert adoptif de TILs. Ces avancées technologiques incitent à mieux comprendre les réponses immunitaires dans ces pathologies et à développer des stratégies combinant
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Chalmin, Fanny. "Rôles des cellules myéloïdes suppressives et des lymphocytes Th17 dans le cancer." Thesis, Dijon, 2012. http://www.theses.fr/2012DIJOMU01.

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Le système immunitaire joue un double rôle dans le cancer: il peut non seulement supprimer la croissance tumorale en détruisant les cellules cancéreuses, mais aussi promouvoir la progression de la tumeur en sélectionnant les cellules tumorales ou en créant un microenvironnement tumoral immunosuppresseur. Au cours de ma thèse, je me suis intéressée à deux populations du système immunitaire : les MDSC (Myeloïd Derived Suppressor Cells) et les lymphocytes Th17. Dans ce travail, nous avons exploré les mécanismes impliqués dans l’activation et dans les fonctions suppressives de ces deux populations
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47

Boyer, Thomas. "Impact des cellules myéloïdes immunosuppressives dans l’induction de cellules souches cancéreuses." Electronic Thesis or Diss., Bordeaux, 2024. http://www.theses.fr/2024BORD0221.

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Le micro-environnement tumoral est fortement influencé par les cellules myéloïdes, dont les macrophages, les neutrophiles et les monocytes sont des représentants majeurs. Les recherches des dernières décennies ont montré que presque toutes les tumeurs sont infiltrées par des cellules myéloïdes, rendant impossible l'existence de tumeurs "froides" en ce qui concerne ces cellules. De plus, les résultats de nombreuses études cliniques se focalisant sur le compartiment immunitaire myéloïde montrent clairement que ces cellules sont presque universellement associées avec un pronostique clinique négat
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48

Bleve, Augusto. "Decoding of epigenetic and metabolic events driving immune diversion of myeloid cells in cancer." Doctoral thesis, Università del Piemonte Orientale, 2020. http://hdl.handle.net/11579/114772.

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Cancers induce ‘emergency’ hematopoiesis and expansion of myeloid-derived suppressor cells (MDSC) and tumor-associated macrophages (TAM), immunosuppressive and tumor-promoting cell populations, correlated with poor prognosis and resistance to chemo-immunotherapies. Molecular characterization of these cells offers new potential therapeutic opportunities. Previously, we showed that nuclear accumulation of p50 NF-kB transcription factor in TAM regulates expression of anti-inflammatory, pro-tumoral genes. Monocytic MDSC share myeloid progenitor and immunosuppressive properties with TAM. Here, we d
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49

marigo, ilaria. "Il programma tollerogenico delle cellule soppressorie di origine mieloide dipende dal fattore di trascrizione C/EBPbeta." Doctoral thesis, Università degli studi di Padova, 2010. http://hdl.handle.net/11577/3422376.

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Tumor growth is associated with a profound alteration of myelopoiesis, leading to recruitment of immunosuppressive cells known as myeloid-derived suppressor cells (MDSCs). Analyzing the cytokines affecting myelo-monocytic differentiation produced by various experimental tumors, we found that GM-CSF, G-CSF and IL-6 allowed a rapid generation of MDSCs from precursors present in mouse bone marrow (BM). BM-MDSCs induced by GM-CSF+IL-6 possessed the highest tolerogenic activity, as revealed by their ability to impair priming of IFN-gamma-producing CD8+ T cells upon in vivo adoptive transfer. Moreo
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50

Peranzoni, Elisa. "Studio dei circuiti di controllo in sottopopolazioni di cellule mieloidi soppressive indotte dalla crescita tumorale." Doctoral thesis, Università degli studi di Padova, 2010. http://hdl.handle.net/11577/3427039.

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Aim of this work was to phenotypically and functionally distinguish myeloid-derived suppressor cell (MDSC) subsets and study their cytokine- and microRNA-mediated regulation. In the first part of the work we silenced granulocyte-macrophage colony stimulating factor (GM-CSF) in 4T1 mammary carcinoma line by means of RNA interference (RNAi), highlighting the relevance of this factor in the preferential induction of suppressive myeloid subpopulations and in the control of their maturation and functional properties. By using this in vivo model, we were also able to show that GM-CSF released by can
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