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Journal articles on the topic 'ME163'

Author: Grafiati

Published: 4 June 2021

Last updated: 1 February 2022

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1

Berardelli, A. "ME13 Pathophysiology of dystonia." Clinical Neurophysiology 119 (May 2008): S4. http://dx.doi.org/10.1016/s1388-2457(08)60020-6.

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H-Kittikun, Aran, Poonsuk Prasertsan, Wolfgang Zimmermann, Phisit Seesuriyachan, and Thanongsak Chaiyaso. "Sugar Ester Synthesis by Thermostable Lipase from Streptomyces thermocarboxydus ME168." Applied Biochemistry and Biotechnology 166, no. 8 (2012): 1969–82. http://dx.doi.org/10.1007/s12010-012-9624-9.

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Neilson, Lynn M., Jianquong Zhu, Jianwu Xie, et al. "Coactivation of Janus Tyrosine Kinase (Jak)1 Positively Modulates Prolactin-Jak2 Signaling in Breast Cancer: Recruitment of ERK and Signal Transducer and Activator of Transcription (Stat)3 and Enhancement of Akt and Stat5a/b Pathways." Molecular Endocrinology 21, no. 9 (2007): 2218–32. http://dx.doi.org/10.1210/me.2007-0173.

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Abstract Prolactin (PRL) receptors (PRLRs) have been considered selective activators of Janus tyrosine kinase (Jak)2 but not Jak1, Jak3, or Tyk2. We now report marked PRL-induced tyrosine phosphorylation of Jak1, in addition to Jak2, in a series of human breast cancer cell lines, including T47D, MCF7, and SKBR3. In contrast, PRL did not activate Jak1 in immortalized, noncancerous breast epithelial lines HC11, MCF10A, ME16C, and HBL-100, or in CWR22Rv1 prostate cancer cells or MDA-MB-231 breast cancer cells. However, introduction of exogenous PRLR into MCF10A, ME16C, or MDA-MB-231 cells reconst

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Coulon, Frédéric, Panagiota-Myrsini Chronopoulou, Anne Fahy, et al. "Central Role of Dynamic Tidal Biofilms Dominated by Aerobic Hydrocarbonoclastic Bacteria and Diatoms in the Biodegradation of Hydrocarbons in Coastal Mudflats." Applied and Environmental Microbiology 78, no. 10 (2012): 3638–48. http://dx.doi.org/10.1128/aem.00072-12.

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ABSTRACTMudflats and salt marshes are habitats at the interface of aquatic and terrestrial systems that provide valuable services to ecosystems. Therefore, it is important to determine how catastrophic incidents, such as oil spills, influence the microbial communities in sediment that are pivotal to the function of the ecosystem and to identify the oil-degrading microbes that mitigate damage to the ecosystem. In this study, an oil spill was simulated by use of a tidal chamber containing intact diatom-dominated sediment cores from a temperate mudflat. Changes in the composition of bacteria and

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YOKOYAMA, T., K. YUYAMA, I. AKOJIMA, and S. MORIYA. "The Rocket Fighter Shusui—as Re-developed from Incomplete and Vague Me163B Data." Transactions of the Newcomen Society 70, no. 1 (1998): 257–76. http://dx.doi.org/10.1179/tns.1998.015.

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Middleton, Douglas. "The profile packThe profile pack Mailing MacDonald et al ME13 8AR FavershamKent£15.95 incl postage." Nursing Standard 6, no. 18 (1992): 44. http://dx.doi.org/10.7748/ns.6.18.44.s53.

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Slingluff, Jr., Craig L., Gina R. Petroni, Kimberly A. Chianese-Bullock, et al. "Trial to evaluate the immunogenicity and safety of a melanoma helper peptide vaccine plus incomplete Freund’s adjuvant, cyclophosphamide, and polyICLC (Mel63)." Journal for ImmunoTherapy of Cancer 9, no. 1 (2021): e000934. http://dx.doi.org/10.1136/jitc-2020-000934.

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BackgroundPeptide vaccines designed to stimulate melanoma-reactive CD4+ T cells can induce T cell and antibody (Ab) responses, associated with enhanced overall survival. We hypothesized that adding toll-like receptor 3 agonist polyICLC to an incomplete Freund’s adjuvant (IFA) would be safe and would support strong, durable CD4+ T cell and Ab responses. We also hypothesized that oral low-dose metronomic cyclophosphamide (mCy) would be safe, would reduce circulating regulatory T cells (T-regs) and would further enhance immunogenicity.Participants and methodsAn adaptive design based on toxicity a

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Guan, Z., J. Sun, Z. Wang, Y. Geng, and W. Xu. "Development of an Open Metadata Schema for Prospective Clinical Research (openPCR) in China." Methods of Information in Medicine 53, no. 01 (2014): 39–46. http://dx.doi.org/10.3414/me13-01-0008.

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SummaryObjectives: In China, deployment of electronic data capture (EDC) and clinical data management system (CDMS) for clinical research (CR) is in its very early stage, and about 90% of clinical studies collected and submitted clinical data manually. This work aims to build an open metadata schema for Prospective Clinical Research (openPCR) in China based on openEHR archetypes, in order to help Chinese researchers easily create specific data entry templates for registration, study design and clinical data collection.Methods: Singapore Framework for Dublin Core Application Profiles (DCAP) is

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Keller, H., M. Müller-Engelmann, M. Heinzel-Gutenbrunner, T. Krones, N. Donner-Banzhoff, and O. Hirsch. "Trying to Optimise the German Version of the OPTION Scale Regarding the Dyadic Aspect of Shared Decision Making." Methods of Information in Medicine 52, no. 06 (2013): 514–21. http://dx.doi.org/10.3414/me13-01-0011.

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Summary Objectives: The OPTION scale (“observing patient involvement in decision making”) assesses the extent to which clinicians involve patients in decisions across a range of situations in clinical practice. It so far just covers physician behavior. We intended to modify the scoring of the OPTION scale to incorpo -rate active patient behavior in consultations. Methods: Modification was done on scoring level, attempting a dyadic, relationship-centred approach in that high ratings can be evoked also by the behaviour of active patients. The German version of the OPTION scale was compared with

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Luzi, D., and F. Pecoraro. "The Integration of the Risk Management Process with the Lifecycle of Medical Device Software." Methods of Information in Medicine 53, no. 02 (2014): 92–98. http://dx.doi.org/10.3414/me13-01-0014.

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SummaryObjectives: The application of software in the Medical Device (MD) domain has become central to the improvement of diagnoses and treatments. The new European regulations that specifically address software as an important component of MD, require complex procedures to make software compliant with safety requirements, introducing thereby new challenges in the qualification and classi -fication of MD software as well as in the performance of risk management activities. Under this perspective, the aim of this paper is to propose an integrated framework that combines the activities to be car

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Bergrath, S., R. Rossaint, S. Thelen, et al. "Employment of Telemedicine in Emergency Medicine." Methods of Information in Medicine 53, no. 02 (2014): 99–107. http://dx.doi.org/10.3414/me13-01-0022.

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SummaryObjectives: Demographic change, rising comorbidity and an increasing number of emer -gencies are the main challenges that emer -gency medical services (EMS) in several countries worldwide are facing. In order to improve quality in EMS, highly trained personnel and well-equipped ambulances are essential. However several studies have shown a deficiency in qualified EMS physicians. Telemedicine emerges as a complementary system in EMS that may provide expertise and improve quality of medical treatment on the scene. Hence our aim is to develop and test a specific teleconsultation system.Met

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Liu, K. E., C. L. Lo, and Y. H. Hu. "Improvement of Adequate Use of Warfarin for the Elderly Using Decision Tree-based Approaches." Methods of Information in Medicine 53, no. 01 (2014): 47–53. http://dx.doi.org/10.3414/me13-01-0027.

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SummaryObjectives: Due to the narrow therapeutic range and high drug-to-drug interactions (DDIs), improving the adequate use of warfarin for the elderly is crucial in clinical practice. This study examines whether the effectiveness of using warfarin among elderly inpatients can be improved when machine learning techniques and data from the laboratory information system are incorporated.Methods: Having employed 288 validated clinical cases in the DDI group and 89 cases in the non-DDI group, we evaluate the prediction performance of seven classification techniques, with and without an Adaptive B

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Kamper, C. H., N. H. Rasmussen, P. Ahrendt, T. S. Toftegaard, O. W. Bertelsen, and S. Wagner. "Reliable Blood Pressure Self-measurement in the Obstetric Waiting Room." Methods of Information in Medicine 53, no. 03 (2014): 225–34. http://dx.doi.org/10.3414/me13-01-0032.

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SummaryBackground: Patients often fail to adhere to clinical recommendations when using current blood pressure self-measurement (BPSM) methods and equipment. As existing BPSM equipment is not able to detect non-adherent behavior, this could result in mis-diagnosis and treatment error. To overcome this problem, we suggest introducing an alternative method for achieving reliable BPSM by measuring additional context meta-data for validating patient adherence. To facilitate this, we have developed ValidAid, a context-aware system for determining patient adherence levels during BPSM.Objectives: The

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Semjonow, A., E. Oezguer, J. Herden, et al. "An Electronic Specimen Collection Protocol Schema (eSCPS)." Methods of Information in Medicine 53, no. 01 (2014): 29–38. http://dx.doi.org/10.3414/me13-01-0035.

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SummaryBackground: The integrity of collection protocols in biobanking is essential for a high-quality sample preparation process. However, there is not currently a well-defined universal method for integrating collection protocols in the biobanking information system (BIMS). Therefore, an electronic schema of the collection protocol that is based on Extensible Markup Language (XML) is required to maintain the integrity and enable the exchange of collection protocols.Materials and Methods: The development and implementation of an electronic specimen collection protocol schema (eSCPS) was perfo

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Brown, S. H., G. Wright, and P. L. Elkin. "Biomedical Informatics: We Are What We Publish." Methods of Information in Medicine 52, no. 06 (2013): 538–46. http://dx.doi.org/10.3414/me13-01-0041.

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SummaryIntroduction: This article is part of a For-Discussion-Section of Methods of Information in Medicine on “Biomedical Informatics: We are what we publish“. It is introduced by an editorial and followed by a commentary paper with invited comments. In subsequent issues the discussion may continue through letters to the editor.Objective: Informatics experts have attempted to define the field via consensus projects which has led to consensus statements by both AMIA. and by IMIA. We add to the output of this process the results of a study of the Pubmed publications with abstracts from the fiel

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Sikora, M., and Ł. Wróbel. "Censoring Weighted Separate-and-Conquer Rule Induction from Survival Data." Methods of Information in Medicine 53, no. 02 (2014): 137–48. http://dx.doi.org/10.3414/me13-01-0046.

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SummaryObjectives: Rule induction is one of the major methods of machine learning. Rule-based models can be easily read and interpreted by humans, that makes them particularly useful in survival studies as they can help clinicians to better understand analysed data and make informed decisions about patient treatment. Although of such usefulness, there is still a little research on rule learning in survival analysis. In this paper we take a step towards rule-based analysis of survival data.Methods: We investigate so-called covering or separate-and-conquer method of rule induction in combination

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Karvounis, E. C., M. G. Tsipouras, A. T. Tzallas, et al. "A Decision Support System for the Treatment of Patients with Ventricular Assist Device Support." Methods of Information in Medicine 53, no. 02 (2014): 121–36. http://dx.doi.org/10.3414/me13-01-0047.

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SummaryBackground: Heart failure (HF) is affecting millions of people every year and it is characterized by impaired ventricular performance, exercise intolerance and shortened life expectancy. Despite significant advancements in drug therapy, mortality of the disease remains excessively high, as heart transplant remains the gold standard treatment for end-stage HF when no contraindications subsist. Traditionally, implanted Ventricular Assist Devices (VADs) have been employed in order to provide circulatory support to patients who cannot survive the waiting time to transplantation, reducing th

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Choi, Y., C. Jung, Y. Chae, et al. "Comparison of Validity of Mapping between Drug Indications and ICD-10." Methods of Information in Medicine 53, no. 03 (2014): 195–201. http://dx.doi.org/10.3414/me13-01-0053.

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SummaryBackground: Mapping of drug indications to ICD-10 was undertaken in Korea by a public and a private institution for their own purposes. A different mapping approach was used by each institution, which presented a good opportunity to compare the validity of the two approaches.Objectives: This study was undertaken to compare the validity of a direct mapping approach and an indirect terminology based mapping approach of drug indications against the gold standard drawn from the results of the two mapping processes.Methods: Three hundred and seventy-five cardiovascular reference drugs were s

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Liu, Y., S. Chiu, Y. Lin, and W. K. Chiou. "Pictogram-based Method of Visualizing Dietary Intake." Methods of Information in Medicine 53, no. 06 (2014): 493–500. http://dx.doi.org/10.3414/me13-01-0072.

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SummaryBackground: Pictograms have been shown by many studies to be an effective way of conveying information. An easy-to-understand pictorial description is essential for communication of dietary intake in the computer era.Objectives: We proposed a novel approach that represents textual descriptions of dietary intake into a pictorial representation with the concept of pictograms. The computational implementation in terms of a web-based tool was investigated on how well the pictograms carry their intended message.Methods: 1) We investigated how well the pictograms are comprehended in terms of

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Preuß, M., and A. Ziegler. "A Simplification and Implementation of Random-effects Meta-analyses Based on the Exact Distribution of Cochran’s Q." Methods of Information in Medicine 53, no. 01 (2014): 54–61. http://dx.doi.org/10.3414/me13-01-0073.

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SummaryBackground: The random-effects (RE) model is the standard choice for meta-analysis in the presence of heterogeneity, and the stand ard RE method is the DerSimonian and Laird (DSL) approach, where the degree of heterogeneity is estimated using a moment-estimator. The DSL approach does not take into account the variability of the estimated heterogeneity variance in the estimation of Cochran’s Q. Biggerstaff and Jackson derived the exact cumulative distribution function (CDF) of Q to account for the variability of Ť 2.Objectives: The first objective is to show that the explicit numerical c

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Haag, M., L. R. Pilz, and D. Schrimpf. "Possible Combinations of Electronic Data Capture and Randomization Systems." Methods of Information in Medicine 53, no. 03 (2014): 202–7. http://dx.doi.org/10.3414/me13-01-0074.

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SummaryBackground: Clinical trials (CT) are in a wider sense experiments to prove and establish clinical benefit of treatments. Nowadays electronic data capture systems (EDCS) are used more often bringing a better data management and higher data quality into clinical practice. Also electronic systems for the randomization are used to assign the patients to the treatments.Objectives: If the mentioned randomization system (RS) and EDCS are used, possibly identical data are collected in both, especially by stratified randomization. This separated data storage may lead to data inconsistency and in

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Cimino, J. J., and X. Jing. "A Complementary Graphical Method for Reducing and Analyzing Large Data Sets." Methods of Information in Medicine 53, no. 03 (2014): 173–85. http://dx.doi.org/10.3414/me13-01-0075.

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SummaryObjectives: Graphical displays can make data more understandable; however, large graphs can challenge human comprehension. We have previously described a filtering method to provide high-level summary views of large data sets. In this paper we demonstrate our method for setting and selecting thresholds to limit graph size while retaining important information by applying it to large single and paired data sets, taken from patient and bibliographic databases.Methods: Four case studies are used to illustrate our method. The data are either patient discharge diagnoses (coded using the Inte

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Abdekhoda, M., A. Dehnad, A. F. Hosseini, and M. Ahmadi. "Information Technology Acceptance in Health Information Management." Methods of Information in Medicine 53, no. 01 (2014): 14–20. http://dx.doi.org/10.3414/me13-01-0079.

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SummaryObjective: User acceptance of information technology has been a significant area of research for more than two decades in the field of information technology. This study assessed the acceptance of information technology in the context of Health Information Management (HIM) by utilizing Technology Acceptance Model (TAM) which was modified and applied to assess user acceptance of health information technology as well as viability of TAM as a research construct in the context of HIM.Methods: This was a descriptive- analytical study in which a sample of 187 personnel from a population of 36

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Kalpathy-Cramer, J., S. You, K. Keck, D. Erdogmus, M. F. Chiang, and E. Ataer-Cansizoglu. "Analysis of Underlying Causes of Inter-expert Disagreement in Retinopathy of Prematurity Diagnosis." Methods of Information in Medicine 54, no. 01 (2015): 93–102. http://dx.doi.org/10.3414/me13-01-0081.

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SummaryObjective: Inter-expert variability in image-based clinical diagnosis has been demonstrated in many diseases including retinopathy of prematurity (ROP), which is a disease affecting low birth weight infants and is a major cause of childhood blindness. In order to better understand the underlying causes of variability among experts, we propose a method to quantify the variability of expert decisions and analyze the relationship between expert diagnoses and features computed from the images. Identification of these features is relevant for development of computer-based decision support sy

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Wilk, S., W. Michalowski, R. Slowinski, et al. "Learning the Preferences of Physicians for the Organization of Result Lists of Medical Evidence Articles." Methods of Information in Medicine 53, no. 05 (2014): 344–56. http://dx.doi.org/10.3414/me13-01-0085.

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SummaryBackground: Online medical knowledge repositories such as MEDLINE and The Cochrane Library are increasingly used by physicians to retrieve articles to aid with clinical decision making. The prevailing approach for organizing retrieved articles is in the form of a rank-ordered list, with the assumption that the higher an article is presented on a list, the more relevant it is.Objectives: Despite this common list-based organization, it is seldom studied how physicians perceive the association between the relevance of articles and the order in which articles are presented. In this paper we

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König, J., M. Blettner, P. Wild, et al. "Combining Cross-sectional Data on Prevalence with Risk Estimates from a Prediction Model." Methods of Information in Medicine 53, no. 05 (2014): 371–79. http://dx.doi.org/10.3414/me13-01-0088.

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SummaryObjectives: Estimation of the attributable risk for fatal diseases by combining two different data sources.Methods: We derive a method to estimate the attributable risks of different risk factors by combining general mortality risks with upto-date prevalences of the risk factors using estimates from a risk prediction model and cross-sectional data of a cohort study. Partial attributable risks have been used to illustrate the proportions of the different risk factors for the attributable risk. In addition we derive standard errors for the attributable risk based on the Taylor series expa

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Marceglia, S., F. Pinciroli, and S. Bonacina. "A Pictorial Schema for a Comprehensive User-oriented Identification of Medical Apps." Methods of Information in Medicine 53, no. 03 (2014): 208–24. http://dx.doi.org/10.3414/me13-01-0093.

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SummaryObjectives: The huge amount of released medical apps prevents medical app users from believing that medical scientific societies and other accreditation bodies as well, have the resources and the power for assigning to any medical app a quality score. By the time being, any medical app user has to take the risks related to the frequently insufficient accreditation of that app. Providing clear user-oriented schemas, to be adopted both when putting a medical App on the market and when an App comes to be evaluated by a cohort or single users, becomes crucial. The aim of our research was to

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Thomas, A. M., J. M. Dean, L. M. Olson, and L. J. Cook. "The Utility of Imputed Matched Sets." Methods of Information in Medicine 53, no. 03 (2014): 186–94. http://dx.doi.org/10.3414/me13-01-0094.

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SummaryObjective: To compare results from high probability matched sets versus imputed matched sets across differing levels of linkage information.Methods: A series of linkages with varying amounts of available information were performed on two simulated datasets derived from multiyear motor vehicle crash (MVC) and hospital databases, where true matches were known. Distributions of high probability and imputed matched sets were compared against the true match population for occupant age, MVC county, and MVC hour. Regression models were fit to simulated log hospital charges and hospitalization

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Ryan, P., J. E. Hiller, and G. Mnatzaganian. "Does Co-morbidity Provide Significant Improvement on Age Adjustment when Predicting Medical Outcomes?" Methods of Information in Medicine 53, no. 02 (2014): 115–20. http://dx.doi.org/10.3414/me13-01-0095.

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SummaryObjective: Using three risk-adjustment methods we evaluated whether co-morbidity derived from electronic hospital patient data provided significant improvement on age adjustment when predicting major outcomes following an elective total joint replacement (TJR) due to osteoarthritis.Methods: Longitudinal data from 819 elderly men who had had a TJR were integrated with hospital morbidity data (HMD) and mortality records. For each participant, any mor bidity or health-related outcome was retrieved from the linked data in the period 1970 through to 2007 and this enabled us to better account

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Goñi, A., A. Illarramendi, and D. Antón. "Exercise Recognition for Kinect-based Telerehabilitation." Methods of Information in Medicine 54, no. 02 (2015): 145–55. http://dx.doi.org/10.3414/me13-01-0109.

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SummaryBackground: An aging population and people’s higher survival to diseases and traumas that leave physical consequences are challenging aspects in the context of an efficient health management. This is why telerehabilitation systems are being developed, to allow monitoring and support of physiotherapy sessions at home, which could reduce healthcare costs while also improving the quality of life of the users.Objectives: Our goal is the development of a Kinect-based algorithm that provides a very accurate real-time monitoring of physical rehabilitation exercises and that also provides a fri

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Arias, M., and F. J. Díez. "Cost-effectiveness Analysis with Influence Diagrams." Methods of Information in Medicine 54, no. 04 (2015): 353–58. http://dx.doi.org/10.3414/me13-01-0121.

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Summary Background: Cost-effectiveness analysis (CEA) is used increasingly in medicine to determine whether the health benefit of an intervention is worth the economic cost. Decision trees, the standard decision modeling technique for non-temporal domains, can only perform CEA for very small problems. Objective: To develop a method for CEA in problems involving several dozen variables. Methods: We explain how to build influence diagrams (IDs) that explicitly represent cost and effectiveness. We propose an algorithm for evaluating cost-effectiveness IDs directly, i.e., without expanding an equi

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Binder, H., O. Gefeller, M. Schmid, and A. Mayr. "The Evolution of Boosting Algorithms." Methods of Information in Medicine 53, no. 06 (2014): 419–27. http://dx.doi.org/10.3414/me13-01-0122.

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SummaryBackground: The concept of boosting emerged from the field of machine learning. The basic idea is to boost the accuracy of a weak classifying tool by combining various instances into a more accurate prediction. This general concept was later adapted to the field of statistical modelling. Nowadays, boosting algorithms are often applied to estimate and select predictor effects in statistical regression models.Objectives: This review article attempts to highlight the evolution of boosting algorithms from machine learning to statistical modelling.Methods: We describe the AdaBoost algorithm

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Binder, H., O. Gefeller, M. Schmid, and A. Mayr. "Extending Statistical Boosting." Methods of Information in Medicine 53, no. 06 (2014): 428–35. http://dx.doi.org/10.3414/me13-01-0123.

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SummaryBackground: Boosting algorithms to simultaneously estimate and select predictor effects in statistical models have gained substantial interest during the last decade.Objectives: This review highlights recent methodological developments regarding boosting algorithms for statistical modelling especially focusing on topics relevant for biomedical research.Methods: We suggest a unified framework for gradient boosting and likelihood-based boosting (statistical boosting) which have been addressed separately in the literature up to now.Results: The methodological developments on statistical bo

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Rühaak, J., R. Werner, H. Handels, J. Modersitzki, and T. Polzin. "Lung Registration Using Automatically Detected Landmarks." Methods of Information in Medicine 53, no. 04 (2014): 250–56. http://dx.doi.org/10.3414/me13-01-0125.

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SummaryObjectives: Accurate registration of lung CT images is inevitable for numerous clinical applications. Usually, nonlinear intensity-based methods are used. Their accuracy is typically evaluated using corresponding anatomical points (landmarks; e.g. bifurcations of bronchial and vessel trees) annotated by medical experts in the images to register. As image registration can be interpreted as correspond ence finding problem, these corresponding landmarks can also be used in feature-based registration techniques. Recently, approaches for automated identification of such landmark corresponden

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Palmerini, L., L. Chiari, and P. Palumbo. "A Probabilistic Model to Investigate the Properties of Prognostic Tools for Falls." Methods of Information in Medicine 54, no. 02 (2015): 189–97. http://dx.doi.org/10.3414/me13-01-0127.

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SummaryBackground: Falls are a prevalent and burdensome problem in the elderly. Tools for the assessment of fall risk are fundamental for fall prevention. Clinical studies for the development and evaluation of prognostic tools for falls show high heterogeneity in the settings and in the reported results. Newly developed tools are susceptible to over- optimism.Objectives: This study proposes a probabilistic model to address critical issues about fall prediction through the analysis of the properties of an ideal prognostic tool for falls.Methods: The model assumes that falls occur within a popul

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Hao, T., and C. Weng. "Adaptive Semantic Tag Mining from Heterogeneous Clinical Research Texts." Methods of Information in Medicine 54, no. 02 (2015): 164–70. http://dx.doi.org/10.3414/me13-01-0130.

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SummaryObjectives: To develop an adaptive approach to mine frequent semantic tags (FSTs) from heterogeneous clinical research texts.Methods: We develop a “plug-n-play” framework that integrates replaceable un-supervised kernel algorithms with formatting, functional, and utility wrappers for FST mining. Temporal information identification and semantic equivalence detection were two example functional wrappers. We first compared this approach’s recall and efficiency for mining FSTs from ClinicalTrials.gov to that of a recently published tag-mining algorithm. Then we assessed this approach’s adap

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Ohlmeier, C., R. Linder, D. Enders, et al. "Evaluating Methods for Intersectoral Comparison of Quality of Care." Methods of Information in Medicine 53, no. 04 (2014): 269–77. http://dx.doi.org/10.3414/me13-01-0132.

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Summary Objectives: To compare the quality of care regarding the use of elective percutaneous coronary interventions (PCIs) in the inpatient and outpatient setting and to evaluate different methods of confounder control in this context. Methods: Based on data of three statutory health insurances including more than nine million insurance members, a retrospective cohort study between 2005 and 2009 was conducted. The occurrence of myocardial infarction, stroke, further coronary intervention and death was ascertained following the first PCI in the study period, which was preceded by a one-year pe

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Christoph, J., L. Griebel, I. Leb, et al. "Secure Secondary Use of Clinical Data with Cloud-based NLP Services." Methods of Information in Medicine 54, no. 03 (2015): 276–82. http://dx.doi.org/10.3414/me13-01-0133.

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SummaryObjectives: The secondary use of clinical data provides large opportunities for clinical and translational research as well as quality assurance projects. For such purposes, it is necessary to provide a flexible and scalable infrastructure that is compliant with privacy requirements. The major goals of the cloud4health project are to define such an architecture, to implement a technical prototype that fulfills these requirements and to evaluate it with three use cases.Methods: The architecture provides components for multiple data provider sites such as hospitals to extract free text as

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Bache, R., M. McGilchrist, C. Daniel, M. Dugas, F. Fritz, and J. Doods. "Piloting the EHR4CR Feasibility Platform across Europe." Methods of Information in Medicine 53, no. 04 (2014): 264–68. http://dx.doi.org/10.3414/me13-01-0134.

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SummaryBackground: Pharmaceutical clinical trials are primarily conducted across many countries, yet recruitment numbers are frequently not met in time. Electronic health records store large amounts of potentially useful data that could aid in this process. The EHR4CR project aims at re-using EHR data for clinical research purposes.Objective: To evaluate whether the protocol feasibility platform produced by the Electronic Health Records for Clinical Research (EHR4CR) project can be installed and set up in accordance with local technical and governance requirements to execute protocol feasibili

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Otte, S., L. Wittig, G. Hüttmann, et al. "Investigating Recurrent Neural Networks for OCT A-scan Based Tissue Analysis." Methods of Information in Medicine 53, no. 04 (2014): 245–49. http://dx.doi.org/10.3414/me13-01-0135.

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Summary Objectives: Optical Coherence Tomography (OCT) has been proposed as a high resolution image modality to guide transbronchial biopsies. In this study we address the question, whether individual A-scans obtained in needle direction can contribute to the identification of pulmonary nodules. Methods: OCT A-scans from freshly resected human lung tissue specimen were recorded through a customized needle with an embedded optical fiber. Bidirectional Long Short Term Memory networks (BLSTMs) were trained on randomly distributed training and test sets of the acquired A-scans. Patient specific tr

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Werner, R., M. Blendowski, J. Ortmüller, H. Handels, and M. Wilms. "Simulation of Range Imaging-based Estimation of Respiratory Lung Motion." Methods of Information in Medicine 53, no. 04 (2014): 257–63. http://dx.doi.org/10.3414/me13-01-0137.

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SummaryObjectives: A major problem associated with the irradiation of thoracic and abdominal tumors is respiratory motion. In clinical practice, motion compensation approaches are frequently steered by low-dimensional breathing signals (e.g., spirometry) and patient-specific correspondence models, which are used to estimate the sought internal motion given a signal measurement. Recently, the use of multidimensional signals derived from range images of the moving skin surface has been proposed to better account for complex motion patterns. In this work, a simulation study is carried out to inve

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Brannath, W., and S. Schmidt. "Informative Simultaneous Confidence Intervals in Hierarchical Testing." Methods of Information in Medicine 53, no. 04 (2014): 278–83. http://dx.doi.org/10.3414/me13-01-0140.

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SummaryBackground and Objectives: In clinical trials involving multiple tests it is often difficult to obtain informative simultaneous confidence intervals (SCIs). In particular in hierarchical testing, no quantification of effects is possible for the first tested (and most important) hypothesis after its rejection. Our goal is a construction of SCIs that are always informative.Methods: We present an approach where the level is split after rejection of each hypothesis to obtain an informative confidence bound. The splitting weights are continuous functions of the parameters. Our method is real

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Fiehler, J., S. Suniaga, H. Wersching, S. Knecht, A. Kemmling, and N. D. Forkert. "A Statistical Cerebroarterial Atlas Derived from 700 MRA Datasets." Methods of Information in Medicine 52, no. 06 (2013): 467–74. http://dx.doi.org/10.3414/me13-02-0001.

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SummaryObjectives: The cerebroarterial system is a complex network of arteries that supply the brain cells with vitally important nutrients and oxygen. The inter-individual differences of the cerebral arteries, especially at a finer level, are still not understood sufficiently. The aim of this work is to present a statistical cerebroarterial atlas that can be used to overcome this problem.Methods: Overall, 700 Time-of-Flight (TOF) magnetic resonance angiography (MRA) data sets of healthy subjects were used for atlas generation. Therefore, the cerebral arteries were automatically segmented in e

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Plischke, M., B. Haarbrandt, M. Rochon, et al. "The Lower Saxony Bank of Health." Methods of Information in Medicine 53, no. 02 (2014): 73–81. http://dx.doi.org/10.3414/me13-02-0003.

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SummaryIntroduction: This article is part of a Focus Theme of Methods of Information in Medicine on Health Record Banking.Background: Poor communication of health care information between health care providers (HCP) is still a major problem. One recent approach is the concept of Health Record Banking.Objectives: With this report we want to introduce the Lower Saxony Bank of Health (LSBH) to the international community. The main objective of this paper is to report and explain: 1) why this organization has been founded, 2) which basic principles have been set, 3) which services will be provided

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von Bargen, T., M. Kohlmann, M. Marschollek, et al. "Home-centered Health-enabling Technologies and Regional Health Information Systems." Methods of Information in Medicine 53, no. 03 (2014): 160–66. http://dx.doi.org/10.3414/me13-02-0008.

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SummaryIntroduction: This article is part of the Focus Theme of Methods of Information in Medicine on “Using Data from Ambient Assisted Living and Smart Homes in Electronic Health Records”.Objectives: In this paper, we present a prototype of a Home-Centered Health- Enabling Technology (HET-HC), which is able to capture, store, merge and process data from various sensor systems at people’s home. In addition, we present an architecture designed to integrate HET-HC into an exem -plary regional Health Information System (rHIS).Methods: rHIS are traditionally document-based to fit to the needs in a

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Chung, J., T. Le, H. Thompson, G. Demiris, and B. Reeder. "Assessing Older Adults’ Perceptions of Sensor Data and Designing Visual Displays for Ambient Environments." Methods of Information in Medicine 53, no. 03 (2014): 152–59. http://dx.doi.org/10.3414/me13-02-0009.

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SummaryIntroduction: This article is part of the Focus Theme of Methods of Information in Medicine on “Using Data from Ambient Assisted Living and Smart Homes in Electronic Health Records“.Objectives: Our objectives were to: 1) characterize older adult participants’ perceived usefulness of in-home sensor data and 2) develop novel visual displays for sensor data from Ambient Assisted Living environments that can become part of electronic health records.Methods: Semi-structured interviews were conducted with community-dwelling older adult participants during three and six-month visits. We engage

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Thiele, S., A. Häber, A. Winter, and T. Nitzsche. "Communication Architecture for AAL." Methods of Information in Medicine 53, no. 03 (2014): 167–72. http://dx.doi.org/10.3414/me13-02-0010.

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SummaryIntroduction: This article is part of the Focus Theme of Methods of Information in Medicine on “Using Data from Ambient Assisted Living and Smart Homes in Electronic Health Records”.Background: Concepts of Ambient Assisted Living (AAL) support a long-term health monitoring and further medical and other services for multi-morbid patients with chronic diseases. In Germany many AAL and telemedical applications exist. Synergy effects by common agreements for essential application components and standards are not achieved.Objectives: It is necessary to define a communication architecture whi

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Evans, J., T. A. Oniki, J. F. Coyle, et al. "Harmonization of Detailed Clinical Models with Clinical Study Data Standards." Methods of Information in Medicine 54, no. 01 (2015): 65–74. http://dx.doi.org/10.3414/me13-02-0019.

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SummaryIntroduction: This article is part of the Focus Theme of Methods of Information in Medicine on “Managing Interoperability and Complexity in Health Systems”.Background: Data sharing and integration between the clinical research data management system and the electronic health record system remains a challenging issue. To approach the issue, there is emerging interest in utilizing the Detailed Clinical Model (DCM) approach across a variety of contexts. The Intermountain Healthcare Clinical Element Models (CEMs) have been adopted by the Office of the National Coordinator awarded Strategic

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García-Remesal, M., D. de la Iglesia, N. Graf, V. Maojo, and A. Anguita. "Toward a View-oriented Approach for Aligning RDF-based Biomedical Repositories." Methods of Information in Medicine 54, no. 01 (2015): 50–55. http://dx.doi.org/10.3414/me13-02-0020.

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SummaryIntroduction: This article is part of the Focus Theme of Methods of Information in Medicine on “Managing Interoperability and Complexity in Health Systems”.Background: The need for complementary access to multiple RDF databases has fostered new lines of research, but also entailed new challenges due to data representation disparities. While several approaches for RDF-based database integration have been proposed, those focused on schema alignment have become the most widely adopted. All state-of-the-art solutions for aligning RDF-based sources resort to a simple technique inherited from

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Vanhove, T., E. Dejonghe, M. Feys, et al. "Platform for Efficient Switching between Multiple Devices in the Intensive Care Unit." Methods of Information in Medicine 54, no. 01 (2015): 05–15. http://dx.doi.org/10.3414/me13-02-0021.

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SummaryIntroduction: This article is part of the Focus Theme of Methods of Information in Medicine on “Managing Interoperability and Complexity in Health Systems”.Objectives: Handheld computers, such as tablets and smartphones, are becoming more and more accessible in the clinical care setting and in Intensive Care Units (ICUs). By making the most useful and appropriate data available on multiple devices and facilitate the switching between those devices, staff members can efficiently integrate them in their workflow, allowing for faster and more accurate decisions. This paper addresses the de

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