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1

TSUTSUMI, TOMOAKI, RIKA ADACHI, RIEKO MATSUDA, TAKAHIRO WATANABE, REIKO TESHIMA, and HIROSHI AKIYAMA. "Concentrations of Polycyclic Aromatic Hydrocarbons in Smoked Foods in Japan." Journal of Food Protection 83, no. 4 (2019): 692–701. http://dx.doi.org/10.4315/jfp-19-486.

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ABSTRACT We evaluated the performance of a gas chromatography–tandem mass spectrometry method for quantifying 16 polycyclic aromatic hydrocarbons (PAHs), which the Scientific Committee on Food and the Joint Food and Agriculture Organization of the United Nations/World Health Organization Expert Committee on Food Additives have considered to be of concern to human health and used the method to determine the PAH concentrations in smoked foods. Eighty-seven samples of smoked fish, smoked meat, smoked eggs, dried bonito flakes, and dried bonito–related soup-stock products (disposable powder packet
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Heiss, John D., Davis P. Argersinger, William H. Theodore, John A. Butman, Susumu Sato, and Omar I. Khan. "Convection-Enhanced Delivery of Muscimol in Patients with Drug-Resistant Epilepsy." Neurosurgery 85, no. 1 (2018): E4—E15. http://dx.doi.org/10.1093/neuros/nyy480.

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Abstract BACKGROUND Minimally invasive therapies for drug-resistant epilepsy (DRE) have been advocated. A study of convection-enhanced delivery (CED) of muscimol, a GABAA receptor agonist, was previously completed in non-human primates. OBJECTIVE To investigate the safety and anti-epileptic effects of intracerebral muscimol infusion into the epileptic focus of patients with DRE. METHODS In this phase 1 clinical trial, 3 adult patients with DRE underwent CED into the seizure focus of artificial CSF vehicle followed by muscimol for 12 to 24 h each using a crossover design. Basic pathophysiology
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Kalantarinia, Kambiz, J. Todd Belcik, James T. Patrie, and Kevin Wei. "Real-time measurement of renal blood flow in healthy subjects using contrast-enhanced ultrasound." American Journal of Physiology-Renal Physiology 297, no. 4 (2009): F1129—F1134. http://dx.doi.org/10.1152/ajprenal.00172.2009.

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Current methods for measuring renal blood flow (RBF) are time consuming and not widely available. Contrast-enhanced ultrasound (CEU) is a safe and noninvasive imaging technique suitable for assessment of tissue blood flow, which has been used clinically to assess myocardial blood flow. We tested the utility of CEU in monitoring changes in RBF in healthy volunteers. We utilized CEU to monitor the expected increase in RBF following a high protein meal in healthy adults. Renal cortical perfusion was assessed by CEU using low mechanical index (MI) power modulation Angio during continuous infusions
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Kurniati, Nining. "Inhibitory Power of Papaya Leaves to the Adhesion of Streptococcus Mutans Bacteria to Neutrophils." Biomedical and Pharmacology Journal 14, no. 3 (2021): 1381–87. http://dx.doi.org/10.13005/bpj/2240.

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Papaya leaves contain several active substances that are thought to inhibit bacterial adhesion. This study aims to determine the inhibitory power of papaya leaf extraction and papaya leaf infusion to the adhesion of Streptococcus mutans bacteria to neutrophils and differences in inhibition in various concentrations. The method used is an in vitro experimental laboratory with a post-test-only control group design. The sample consisted of several concentrations of papaya leaf extraction and papaya leaf infusion (control, 25%, 50%, 75%, and 100%). The treatment group was added with neutrophil iso
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Crispie, Fiona, Denis Twomey, James Flynn, Colin Hill, Paul Ross, and William Meaney. "The lantibiotic lacticin 3147 produced in a milk-based medium improves the efficacy of a bismuth-based teat seal in cattle deliberately infected with Staphylococcus aureus." Journal of Dairy Research 72, no. 2 (2005): 159–67. http://dx.doi.org/10.1017/s0022029905000816.

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A preparation of the bacteriocin lacticin 3147 (prepared from a demineralized whey protein fermentation liquor) was combined as a powder with a bismuth-based intramammary teat seal and evaluated for its potential as an antimicrobial in non-lactating cows. The lacticin/teat seal formulation enabled significant bacteriocin release from the seal without the requirement for a surfactant. Studies in vivo in lactating cows demonstrated that this formulation was effective in reducing bacterial recoveries (~20-fold) from teats deliberately inoculated with Staphylococcus aureus after infusion. Moreover
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van den Horn, G. J., N. Westerhof, and G. Elzinga. "Feline left ventricle does not always operate at optimum power output." American Journal of Physiology-Heart and Circulatory Physiology 250, no. 6 (1986): H961—H967. http://dx.doi.org/10.1152/ajpheart.1986.250.6.h961.

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In a previous study we showed that under a variety of conditions the feline left ventricle operates at optimum external power. This condition was defined as matching. In the present study matching of left ventricle and systemic arterial tree has been further investigated in the open-thorax cat during control, after volume loading (n = 8), and during norepinephrine infusion (n = 8). The pump-function graph relating mean left ventricular pressure and mean flow was fitted with a parabola characterized by two parameters, the pressure axis and the flow axis intercepts (Pmax and Fmax, respectively).
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7

Fabus, M. S., D. Casey, K. Warnaby, M. Woolrich, and R. McShane. "Electroencephalogram monitoring during ketamine antidepressant treatment: a pilot study." European Psychiatry 67, S1 (2024): S378—S379. http://dx.doi.org/10.1192/j.eurpsy.2024.778.

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Introduction Depression is a major cause of disability world-wide. Up to a third of patients have a treatment-resistant form (TRD), presenting a major challenge. Ketamine has been introduced as a novel rapid-acting antidepressant effective in this population. However, at present, ketamine treatment is not routinely informed by any objective neural markers. Basic research has shown promising electroencephalogram (EEG) changes including a decrease in alpha power. However, clinical translation is lacking.ObjectivesAssess the feasibility of identifying EEG correlates of ketamine infusions in a rou
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Meyer, Jürgen, Jeppe Sturis, Martin Katschinski, Rudolf Arnold, Burkhard Göke та Maria M. Byrne. "Acute hyperglycemia alters the ability of the normal β-cell to sense and respond to glucose". American Journal of Physiology-Endocrinology and Metabolism 282, № 4 (2002): E917—E922. http://dx.doi.org/10.1152/ajpendo.00427.2001.

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Impaired glucose tolerance (IGT) and non-insulin-dependent diabetes mellitus (NIDDM) are associated with an impaired ability of the β-cell to sense and respond to small changes in plasma glucose. The aim of this study was to establish whether acute hyperglycemia per se plays a role in inducing this defect in β-cell response. Seven healthy volunteers with no family history of NIDDM were studied on two occasions during a 12-h oscillatory glucose infusion with a periodicity of 144 min. Once, low-dose glucose was infused at a mean rate of 6 mg · kg−1 · min−1 and amplitude 33% above and below the m
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9

SA, Belal, MK Hasan, MS Islam, MS Islam, and MA Islam. "EFFECT OF GINGER (ZINGIBER OFFICINALE) AND GARLIC (ALLIUM SATIVUM) ON PRODUCTIVE PERFORMANCE AND HEMATOLOGICAL PARAMETERS OF BROILER." EPH - International Journal of Agriculture and Environmental Research 3, no. 1 (2018): 9–16. http://dx.doi.org/10.53555/eijaer.v4i1.23.

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The present study was carried out to investigate the effect of ginger and garlic on the productive performance, carcass characteristics and hematological parameters of broilers. Ginger and garlic were provided alone and combination of both through the diet and drinking water in the form of powder and infusion respectively. A total of 200 one-day-old Cobb-500 straight-run broiler chicks were randomly allocated to five experimental treatments with four replications of 10 chicks per replicate (n=40). Treatments were: T0 (control group without test ingredients), T1 and T2 : (birds received 15 g kg
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10

Rajiv, D., Diana Prem, Maya Ramesh, Mathew Jacob, and K. Indrapriyadharshini. "Fluoride content in various types of tea used by tea stalls in Salem district – An in vitro cross sectional study." Journal of Oral and Maxillofacial Pathology 27, no. 2 (2023): 328–32. http://dx.doi.org/10.4103/jomfp.jomfp_346_22.

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Background: Tea leaves are natural rich source of fluoride and are known as fluorine absorbants. It is consumed on large scale in India and thus needs to be monitored for its daily fluoride consumption by customers. Tea manufacturers should mention fluoride concentrations on the packages to avoid overdose through unknown consumption by consumers. Objectives: To detect the levels of fluoride in tea at different periods of boiling and to compare the fluoride levels in various brands of tea at different periods of boiling. Methodology: A survey was conducted in 25 tea stalls of Salem on the type
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11

Quezado, Z. M., W. D. Hoffman, J. A. Winkelstein, et al. "The third component of complement protects against Escherichia coli endotoxin-induced shock and multiple organ failure." Journal of Experimental Medicine 179, no. 2 (1994): 569–78. http://dx.doi.org/10.1084/jem.179.2.569.

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We investigated whether the third component of complement (C3) is involved in the pathophysiology of endotoxic shock, and if it is involved, whether it plays a protective role or whether it mediates shock and multiple organ failure. In a prospective, controlled investigation, six Brittany spaniels that were homozygous for a genetically determined deficiency of C3 (C3 deficient, < 0.003% of normal serum C3 levels) and six heterozygous littermates (controls, approximately 50% of mean normal serum C3 level) were given 2 mg/kg of reconstituted Escherichia coli 026:B6 acetone powder as a sou
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Edenfield, W. Jeffrey, Bassam Mattar, Stephen P. Anthony, Peter Mutch, Brian Chanas, and Mark Smith. "Phase 1, Open-Label, Randomized, Bioequivalence Study of 2 Bendamustine Hydrochloride Formulations; A Ready-to-Dilute Low-Volume, Rapid Infusion Solution and a Lyophilized Powder Formulation." Blood 126, no. 23 (2015): 4857. http://dx.doi.org/10.1182/blood.v126.23.4857.4857.

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Abstract Introduction: This phase 1, open-label, randomized, crossover study assessed the bioequivalence (BE) and safety of an investigational, ready-to-dilute, rapid infusion, low-volume solution of bendamustine hydrochloride (test product [T]) and the approved bendamustine lyophilized powder formulation (reference product [R]). [CT.gov ID NCT02162888] Methods: Eligible patients (Pts) were aged 18 years or older with relapsed or refractory solid tumors or hematologic malignancies excluding chronic lymphocytic leukemia. All Pts received bendamustine 120 mg/m2 intravenously as T (in 50 mL; 0.9%
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Tulppo, Mikko P., Heikki V. Huikuri, Elli Tutungi, et al. "Feedback effects of circulating norepinephrine on sympathetic outflow in healthy subjects." American Journal of Physiology-Heart and Circulatory Physiology 288, no. 2 (2005): H710—H715. http://dx.doi.org/10.1152/ajpheart.00540.2004.

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The amplitude of low-frequency (LF) oscillations of heart rate (HR) usually reflects the magnitude of sympathetic activity, but during some conditions, e.g., physical exercise, high sympathetic activity results in a paradoxical decrease of LF oscillations of HR. We tested the hypothesis that this phenomenon may result from a feedback inhibition of sympathetic outflow caused by circulating norepinephrine (NE). A physiological dose of NE (100 ng·kg−1·min−1) was infused into eight healthy subjects, and infusion was continued after α-adrenergic blockade [with phentolamine (Phe)]. Muscle sympatheti
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Godeau, Bertrand, Olivier Fain, Raphael Porcher, et al. "Rituximab Is an Alternative to Splenectomy in Adults with Chronic Immune Thrombocytopenic Purpura: Results of a Multicenter Prospective Phase 2 Study." Blood 108, no. 11 (2006): 478. http://dx.doi.org/10.1182/blood.v108.11.478.478.

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Abstract Background : Rituximab, a monoclonal anti-CD20 antibody, is a promising therapeutic agent for adults with immune thrombocytopenic purpura (ITP). Pooling results of the published literature suggest that rituximab achieves an initial response in about 50 % of adults with chronic ITP, with a 25–40% rate of sustained response. However, heterogeneity of patient pre-treatment status, short follow up and bias due to retrospective studies limit the interpretation of the data. Objective : To assess the safety and efficacy of rituximab in adults with chronic ITP (duration ≥ 6 months) and platel
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Galinsky, Robert, Vittoria Draghi, Guido Wassink, et al. "Magnesium sulfate reduces EEG activity but is not neuroprotective after asphyxia in preterm fetal sheep." Journal of Cerebral Blood Flow & Metabolism 37, no. 4 (2016): 1362–73. http://dx.doi.org/10.1177/0271678x16655548.

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Magnesium sulfate is now widely recommended for neuroprotection for preterm birth; however, this has been controversial because there is little evidence that magnesium sulfate is neuroprotective. Preterm fetal sheep (104 days gestation; term is 147 days) were randomly assigned to receive sham occlusion (n = 7), i.v. magnesium sulfate (n = 10) or saline (n = 8) starting 24 h before asphyxia until 24 h after asphyxia. Sheep were killed 72 h after asphyxia. Magnesium sulfate infusion reduced electroencephalograph power and fetal movements before asphyxia. Magnesium sulfate infusion did not affect
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16

James, L. P., M. G. Kris, R. T. Heelan, et al. "A phase II study to determine if sensory neuropathy of nab-paclitaxel can be reduced by prolonging infusion in patients with non-small cell lung cancer (NSCLC)." Journal of Clinical Oncology 25, no. 18_suppl (2007): 18087. http://dx.doi.org/10.1200/jco.2007.25.18_suppl.18087.

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18087 Background: We have previously reported that nab-paclitaxel (ABI-007; Abraxane) administered at 125 mg/m2 over 30 minutes on days 1, 8, and 15 every 28 days has a response rate (RR) of 30% and median survival of 11 months [Rizvi, Proc. ASCO 2006]. We also observed 15/40 (38%) patients developed grade 2/3 sensory neuropathy with a 30 minute infusion. We hypothesize that a longer infusion with nab-paclitaxel may reduce peak plasma levels and accordingly reduce sensory neuropathy. Methods: After enrollment of 40 patients at 125 mg/m2 over 30 minutes on days 1, 8, and 15 every 28 days, we am
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Testoni, S., L. Magnani, A. Spinella, C. Salvarani, D. Giuggioli, and P. Macchioni. "AB0840 ACUTE VASCULAR EFFECTS OF INTRAVENOUS ILOPROST IN SCLERODERMA PATIENTS CAN BE DETECTED BY POWER DOPPLER EXAMINATION OF THE FINGER SUBCUTANEOUS TISSUE." Annals of the Rheumatic Diseases 82, Suppl 1 (2023): 1633.1–1633. http://dx.doi.org/10.1136/annrheumdis-2023-eular.5735.

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BackgroundIntravenous iloprost (ILO) is used in the treatment of refractory Raynaud phenomenon and scleroderma (SSc) digital ulcers. To date, there are no recommended imaging modalities to monitor ILO vascular effects. So far few studies explored ultrasound (US) as a tool to assess vascular subcutaneous involvement in patients affected by SSc.ObjectivesWe aim to evaluate the acute vascular effects of intravenous ILO infusion by power Doppler US (PDUS) examination at periungual (PU) and finger pulp (FP) subcutaneous areas in a consecutive series of SSc patients.MethodsTen consecutive SSc patien
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Paul, Surajit, and Vaskar Majumdar. "Comparison of Dexmedetomidine, midazolam and propofol for sedation of post operative patients on mechanical ventilation- An open label randomised control trial." Indian Journal of Clinical Anaesthesia 8, no. 3 (2021): 392–95. http://dx.doi.org/10.18231/j.ijca.2021.075.

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Mechanical ventilation is a life-sustaining therapy for the treatment of patients with acute respiratory failure. One of the key factors for good clinical practice in the ICU is to provide adequate sedation. An ideal sedative should provide a rapid onset, a rapid recovery. On this background the present study is designed to evaluate the efficacy and safety of dexmedetomidine, propofol and midazolam for sedating property, hemodynamic effects and analgesic. It is an open label, single blinded randomized control trial. Census sampling is planned for recruitment which will have maximum power and t
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Diez-Fernández, Raúl, Rocío Vázquez-Sánchez, Laura López-Esteban, et al. "Ethanol-induced symptoms in patients receiving gemcitabine diluted from a concentrate for solution for infusion containing ethanol." Journal of Oncology Pharmacy Practice 24, no. 7 (2017): 511–16. http://dx.doi.org/10.1177/1078155217715790.

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Purpose Ethanol as an excipient is used to enhance the solubility of gemcitabine, but, sometimes, the dose of ethanol a patient may be given is much higher than the dose considered to be toxic. We aimed to assess ethanol-related symptoms and signs in patients receiving two formulations of gemcitabine, with and without ethanol. Methods A randomized double blind cross-over study was conducted. All patients being treated with gemcitabine received two consecutive doses of the drug, one diluted from a concentrate for solution for infusion (CSI) containing ethanol and the other from a lyophilized po
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Ploysongsang, Y., R. P. Michel, A. Rossi, L. Zocchi, J. Milic-Emili, and N. C. Staub. "Early detection of pulmonary congestion and edema in dogs by using lung sounds." Journal of Applied Physiology 66, no. 5 (1989): 2061–70. http://dx.doi.org/10.1152/jappl.1989.66.5.2061.

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Five mongrel dogs (2 interstitial and 3 alveolar edema) were studied. Lung mechanics were measured by recording the flow, volume, and esophageal pressure according to the standard technique. Edema was produced by infusion of Ringer lactate solution. Lung sounds were recorded on tape from the dependent part of the chest wall. Lung sound signals were high-pass filtered at 100 Hz and subjected to fast Fourier transform. Samples of lung sounds were analyzed before (control) and at 5, 10, 20, 30, and 40 min after the infusion. The mean, median, and mode frequencies of sound power spectra at the con
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Goldblum, S. E., D. A. Cohen, M. N. Gillespie, and C. J. McClain. "Interleukin-1-induced granulocytopenia and pulmonary leukostasis in rabbits." Journal of Applied Physiology 62, no. 1 (1987): 122–28. http://dx.doi.org/10.1152/jappl.1987.62.1.122.

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Pulmonary leukostasis is a postulated prerequisite lesion for acute lung injury. Interleukin-1 (IL-1) mediates components of the acute-phase response, stimulates granulocyte metabolism and secretion, and augments endothelial adhesiveness. We studied the effects of murine IL-1 infusion on circulating granulocytes, their sequestration within the pulmonary microvasculature, lung water, and bronchoalveolar lavage fluid (BALF) protein concentration in rabbits at 3 and 24 h after infusion. IL-1 administration induced significant (P less than 0.01) granulocytopenia compared with saline-injected contr
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22

OKUTSU, I., I. HAMANAKA, and A. YOSHIDA. "Pre- and Postoperative Guyon’s Canal Pressure Change in Endoscopic Carpal Tunnel Release: Correlation with Transient Postoperative Guyon’s Canal Syndrome." Journal of Hand Surgery (European Volume) 34, no. 2 (2009): 208–11. http://dx.doi.org/10.1177/1753193408100122.

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Perioperative Guyon’s canal and carpal canal pressure in one-forearm portal endoscopic carpal tunnel release surgery were measured in resting position and during active power gripping in 66 hands. This was done using the continuous infusion technique with a local anaesthetic and without pneumatic tourniquet. Immediate mean postoperative Guyon’s canal and carpal canal pressure decreased in both measurements. During active power gripping, postoperative Guyon’s canal pressure was less than 40 mmHg in 61 hands, however, this increased to over 40 mmHg in five hands. In these five hands, Guyon’s can
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23

Akeju, Oluwaseun, Kara J. Pavone, M. Brandon Westover, et al. "A Comparison of Propofol- and Dexmedetomidine-induced Electroencephalogram Dynamics Using Spectral and Coherence Analysis." Anesthesiology 121, no. 5 (2014): 978–89. http://dx.doi.org/10.1097/aln.0000000000000419.

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Abstract Background Electroencephalogram patterns observed during sedation with dexmedetomidine appear similar to those observed during general anesthesia with propofol. This is evident with the occurrence of slow (0.1 to 1 Hz), delta (1 to 4 Hz), propofol-induced alpha (8 to 12 Hz), and dexmedetomidine-induced spindle (12 to 16 Hz) oscillations. However, these drugs have different molecular mechanisms and behavioral properties and are likely accompanied by distinguishing neural circuit dynamics. Methods The authors measured 64-channel electroencephalogram under dexmedetomidine (n = 9) and pro
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Goldman, Ernesto, Christer Sinderby, Lars Lindstrom, and Alex Grassino. "Influence of Atracurium on the Diaphragm Mean Action Potential Conduction Velocity in Canines." Anesthesiology 90, no. 3 (1999): 855–62. http://dx.doi.org/10.1097/00000542-199903000-00029.

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Background It has been shown that progressive neuromuscular blockade (NMB) affects the electromyogram power spectrum and compound muscle action potential duration in skeletal muscle. These measures are linked to the mean muscle action potential conduction velocity (APCV), but no studies have confirmed a relation between the mean APCV and NMB. The aim of this study was to determine whether diaphragm mean APCV is affected by NMB. Methods The effects of NMB on diaphragm mean APCV were evaluated in five mongrel dogs. Progressive NMB was induced by slow intravenous infusion of atracurium. During sp
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Macedo, Julia Borges de, Edmar Miyoshi, Sinvaldo Baglie, and Thomas Markus D'Haese. "Evaluation of vasopressin use in the management of refractory shock in patients admitted to the intensive care unit." Research, Society and Development 11, no. 9 (2022): e12611932418. http://dx.doi.org/10.33448/rsd-v11i9.32418.

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Refractory shock is characterized by hemodynamic instability unresponsive to norepinephrine with a high mortality rate. As there are still doubts regarding the pharmacological benefit of the vasopressin addition, this retrospective study aimed to assess the profile of vasopressin use in the intensive care unit of a university hospital in Paraná, Brazil. The information collected was obtained through the analysis of electronic medical records. 73 patients with refractory shock, mainly of septic etiology (61.6%), were included. The dose (μg/Kg/minute) and duration of norepinephrine, upon finding
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S. Raheem, Sahar, Mufeda AL-Ammar, and Muayad Sarbeet. "Leukemia Inhibitory Factor as an Indicator for Determination of the Optimal Time of Intrauterine PRP Infusion in ICSI Cases." IraQi Journal of Embryos and Infertility Researches 13, no. 2 (2023): 1–15. http://dx.doi.org/10.28969/ijeir.v13.i2.r1.23.

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The compromise of uterine receptivity is one of the main reasons for the failure of assisted reproduction techniques. Leukemia inhibitory factor is one of those molecular parameters that allow us to identify an endometrium as receptive. Platelet rich plasma (PRP) contains a range of cytokines and growth factors including leukemia inhibitory factor that encourage the migration, proliferation, and differentiation of cells. Treatments for antagonist ovarian stimulation were administered to 75 women under the age of 40, and 2-D power doppler ultrasound was used to guide the oocyte harvest. Patient
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Yusof, Mahsyuri, and Muhammad Afifi Amalina. "Effect of Filler Size on Flexural Properties of Calcium Carbonate Derived from Clam Shell Filled with Unsaturated Polyester Composites." Key Engineering Materials 594-595 (December 2013): 57–62. http://dx.doi.org/10.4028/www.scientific.net/kem.594-595.57.

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The effect of filler size to the flexural properties of the calcium carbonate (CaCO3) filled with unsaturated polyester (UP) composites have been experimentally investigated. The filler was derived from the shell of local clam known asPolymesoda bengalensis. The ground shells were graded into eight different sizes according to the sieve aperture size of which they could pass through. The sample with 4 wt% CaCO3reinforced with UP was fabricated. Then, the flexural test was done according to the ASTM D790. The result shows that for micron size filler, the flexural modulus was improved as the pow
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Cho, Kenta H. T., Natalya Hounsell, Evelyn McClendon, et al. "Postischemic Infusion of Apigenin Reduces Seizure Burden in Preterm Fetal Sheep." International Journal of Molecular Sciences 24, no. 23 (2023): 16926. http://dx.doi.org/10.3390/ijms242316926.

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Seizures are common in preterm newborns and are associated with poor neurodevelopmental outcomes. Current anticonvulsants have poor efficacy, and many have been associated with upregulation of apoptosis in the developing brain. Apigenin, a natural bioactive flavonoid, is a potent inhibitor of hyaluronidase and reduces seizures in adult animal models. However, its impact on perinatal seizures is unclear. In the present study, we examined the effect of apigenin and S3, a synthetic, selective hyaluronidase inhibitor, on seizures after cerebral ischemia in preterm fetal sheep at 0.7 gestation (98–
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Czosnyka, Marek, Zofia Czosnyka, Nicole Keong, et al. "Pulse pressure waveform in hydrocephalus: what it is and what it isn't." Neurosurgical Focus 22, no. 4 (2007): 1–7. http://dx.doi.org/10.3171/foc.2007.22.4.3.

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Object Apart from its mean value, the pulse waveform of intracranial pressure (ICP) is an essential element of pressure recording. The authors reviewed their experience with the measurement and interpretation of ICP pulse amplitude by referring to a database of recordings in hydrocephalic patients. Methods The database contained computerized pressure recordings from 2100 infusion studies (either lumbar or intraventricular) or overnight ICP monitoring sessions in patients suffering from hydrocephalus of various types (both communicating and noncommunicating), origins, and stages of management (
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TENLİK, İlyas, Ömer ÖZTÜRK, Derya ARI, et al. "Jejunal levodopa infüzyonu alan Parkinson hastalarında PEG-J tüpünün kısa ve uzun dönem güvenilirliği ve devamlılığı." Journal of Medicine and Palliative Care 4, no. 5 (2023): 389–94. http://dx.doi.org/10.47582/jompac.1332644.

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Aims: To investigate PEG-J related adverse events and tube durability in patients with Parkinson’s disease who underwent PEG-J procedure for jejunal drug infusion. 
 Methods: PEG-J implanted patients, who were planned jejunal levodopa infusion, were included in the study. The demographic characteristics of the patients, tube durability, tube replacement, reason for tube replacement, number of procedures, and adverse events related to procedures were retrospectively analyzed. 
 Results: Thirty-four patients with a mean age of 65.7±9.8 years included in the study. The mean total PEG-J
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Valdez-Solana, Mónica A., Verónica Y. Mejía-García, Alfredo Téllez-Valencia, et al. "Nutritional Content and Elemental and Phytochemical Analyses ofMoringa oleiferaGrown in Mexico." Journal of Chemistry 2015 (2015): 1–9. http://dx.doi.org/10.1155/2015/860381.

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Moringa oleiferais a tree distributed in Mexican semiarid and coastal regions.M. oleiferais used in practice in the treatment of various diseases and is available without a medical prescription, often in the form of an herbal infusion for everyday use. The aim of the present study was to evaluate the chemical composition and nutritional values of driedM. oleiferaleaf powder collected from two different regions in Mexico. All samples ofM. oleiferaexhibited moisture levels varying from 3.06 to 3.34%, lipids from 10.21 to 10.31%, fiber from 7.29 to 9.46%, ashes from 10.71 to 11.18%, crude protein
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PAOLISSO, Giuseppe, Daniela MANZELLA, Maria Rosaria RIZZO, et al. "Effects of insulin on the cardiac autonomic nervous system in insulin-resistant states." Clinical Science 98, no. 2 (2000): 129–36. http://dx.doi.org/10.1042/cs0980129.

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The effects of insulin infusion on cardiac autonomic nervous system (ANS) activity were investigated in healthy subjects (n = 15) and in patients with various types of insulin-resistance, such as obese subjects (n = 20) and those with hypertension (n = 15) or type II (non-insulin-dependent) diabetes (n = 22). Healthy subjects and patients underwent euglycaemic hyperinsulinaemic glucose clamp, and cardiac ANS and haemodynamic changes were investigated by continuous recording of heart rate variability by the Holter technique and by venous occlusion plethysmography respectively. At baseline, heal
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Rahmatullah, Wafaa, Manal Al-Obaidi, and Huda Hussaini. "Effect of Autologous Platelet-Rich Plasma (PRP) Treatment on Endometrial Receptivity in ICSI cases." Iraqi Journal of Embryos and Infertility Researches 10, no. 2 (2021): 73–89. http://dx.doi.org/10.28969/ijeir.v10.i2.r6.

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The crosstalk between a receptive endometrium and a functional blastocyst during human embryo implantation is crucial for conception. Because platelets rich plasma (PRP) with concentrated platelets 4-5 times higher than normal, when release of granules containing growth factors including VEGF, TGF, PDGF, IGF, and EGF, these factors involved for sub endometrial angiogenesis and endometrial receptivity. 44 women under the age of 40 were given antagonist ovarian stimulation treatments, the oocytes were harvested utilizing 2-D power doppler ultrasound guidance, then ICSI done for them. On the hCG
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EHIELU, R. O., H. I. AJAYI, J. I. IMOUOKHOME, and I. I. ILABOYA. "EFFECT OF Vernonia Amygdalina LEAF MEAL EXTRACT IN DRINKING WATER ON POST-WEANING DIARRHEA OCCURRENCE IN PIGLETS." FUDMA Journal of Agriculture and Agricultural Technology 9, no. 2 (2023): 29–39. http://dx.doi.org/10.33003/jaat.2023.0902.04.

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This study was aimed at determining the effect of Vernonia amygdalina leaf meal (VALM) extract in drinking water on the faecal microbial load on post-weaning diarrhea occurrence in piglets using different agar. Forty-five piglets of Large white X Duroc breed were given Vernonia amygdalina (VA) through water infusion. Three levels of 0.0g, 1.2g, and 2.4g of VA per 1000ml of clean drinking water designated as T1, T2, and T3 were used. Nine piglets weaned at different ages of 2nd, 3rd, 4th, 5th, and 6th week of age were randomly allotted to three treatments with each treatment replicated three ti
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Braughler, J. Mark, Edward D. Hall, Eugene D. Means, Thomas R. Waters, and Douglas K. Anderson. "Evaluation of an intensive methylprednisolone sodium succinate dosing regimen in experimental spinal cord injury." Journal of Neurosurgery 67, no. 1 (1987): 102–5. http://dx.doi.org/10.3171/jns.1987.67.1.0102.

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✓ Beginning 30 minutes after compression trauma of the upper lumbar (L-2) spinal cord, cats were treated with either a high-dose regimen of methylprednisolone (MP) administered as the sodium salt of the 21-succinate ester (Solu-Medrol sterile powder) or the MP vehicle. Animals were randomly assigned to either treatment group (10 cats per group), and all personnel were blind as to which animals received vehicle or drug. The intensive 48-hour dosing regimen was designed to maintain therapeutic tissue levels of MP and consisted of an initial 30 mg/kg intravenous bolus of MP; 2 and 6 hours later a
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Goldblum, S. E., M. Jay, K. Yoneda, D. A. Cohen, C. J. McClain, and M. N. Gillespie. "Monokine-induced acute lung injury in rabbits." Journal of Applied Physiology 63, no. 5 (1987): 2093–100. http://dx.doi.org/10.1152/jappl.1987.63.5.2093.

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Interleukin-1 (IL-1) mediates components of the acute phase response, stimulates granulocyte metabolism, and induces endothelial cell surface changes. We studied in unanesthetized rabbits the effects of intravenous divided dose infusions of a murine monokine preparation containing IL-1 activity, on circulating granulocytes, their sequestration within the pulmonary microvasculature, pulmonary edema formation, and changes in pulmonary vascular permeability. Monokine administration induced significant (P less than 0.01) granulocytopenia as well as a significant (P less than 0.001) increase in mea
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Pagtalunan, M. E., R. Rasch, H. G. Rennke, and T. W. Meyer. "Morphometric analysis of effects of angiotensin II on glomerular structure in rats." American Journal of Physiology-Renal Physiology 268, no. 1 (1995): F82—F88. http://dx.doi.org/10.1152/ajprenal.1995.268.1.f82.

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Micropuncture and morphometric studies related the effects of angiotensin II (ANG II) on glomerular function and structure. Compared with control animals, rats receiving an intrarenal infusion of ANG II at 40 ng.kg-1.min-1 exhibited a marked reduction in the glomerular ultrafiltration coefficient (Kf) (0.84 +/- 0.13 vs. 1.43 +/- 0.05 microliters.s-1.mmHg-1, ANG II vs. control), which caused a decrease in glomerular filtration rate (GFR) (1.04 +/- 0.11 vs. 1.27 +/- 0.11 ml/min) despite an increase in glomerular transcapillary hydraulic pressure difference (46 +/- 1 vs. 40 +/- 1 mmHg). Morphomet
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Yoshigi, M., N. Hu, and B. B. Keller. "Dorsal aortic impedance in stage 24 chick embryo following acute changes in circulating blood volume." American Journal of Physiology-Heart and Circulatory Physiology 270, no. 5 (1996): H1597—H1606. http://dx.doi.org/10.1152/ajpheart.1996.270.5.h1597.

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The effects of acute changes in circulating blood volume on embryonic vascular hemodynamics were evaluated with the use of input impedance. We simultaneously measured dorsal aortic pressure with a servo-null system and flow velocity with a 20-MHz pulsed Doppler system in n = 90 stage 24 chick embryos. We withdrew or infused 1,3, or 5 microliters of blood via a second-order vitelline vein (n = 10 per group). In addition, we withdrew and then infused or infused and then withdrew 3 microliters (n = 5 per group). Characteristic impedance, peripheral resistance, arterial compliance and elastance, a
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Hailu, Seyoum, Shimelis Abbabu, Ashenafi Seifu, Naol Gorde, and Aschalew Besha. "Effectiveness of different doses of dexmedetomidine on intraoperative haemodynamic profiles and postoperative pain in patients undergoing abdominal surgery at Dilla University Referral Hospital, Ethiopia, 2024: a double-blind randomized controlled trial." Annals of Medicine & Surgery 86, no. 8 (2024): 4495–504. http://dx.doi.org/10.1097/ms9.0000000000002094.

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Background and objective: Abdominal surgery stands as one of the most frequently conducted procedures across surgical specialties, accounting for up to half of surgery-related expenses. Hemodynamic instability emerges as a significant concern during anaesthesia and surgery, provoked by the stress of intubation, surgical incision, and anaesthetic agents. Following abdominal surgery, pain is an inevitable consequence, typically managed with opioid-based analgesia. However, the adverse effects associated with opioids often overshadow their analgesic benefits, particularly in the context of abdomi
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CHIFAMBA, J., A. MUTAMBA, and R. MUTUNGA. "Antifertility Activity of Crude Extracts of Pouzolzia mixta in Female Rats." Journal of Complementary and Alternative Medical Research 26, no. 7 (2025): 83–91. https://doi.org/10.9734/jocamr/2025/v26i7676.

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Pouzolzia Mixta (hypoleuca), is a small multi- stemmed shrub tree from the Urticaceae family found throughout Southern Africa. The dried shrub’s root powder has been the traditional contraception for Zimbabwean women for centuries. Traditionally believed to possess postcoital anti-fertility activity, the dried ground powder is taken in mealie meal porridge the morning after sexual intercourse to prevent pregnancy or as an infusion in beverages. The root powder efficacy and safety however remain scientifically unsubstantiated. Apart from poor adherence issues, current conventional emergency con
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Ke, Jing-Dong, Min Xu, Pei-Pei Wang, Min Wang, Ming Tian, and Andrew C. N. Chen. "Influence of propofol on the electroencephalogram default mode network in patients of advanced age." Journal of International Medical Research 46, no. 11 (2018): 4660–68. http://dx.doi.org/10.1177/0300060518788241.

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Objective This study was performed to evaluate the effects of propofol on the electroencephalogram (EEG) default mode network (DMN) in patients of advanced age. Methods Fifteen men aged >60 years (mean, 70 years) were selected. Propofol target-controlled infusion was performed under EEG bispectral index monitoring. The propofol target effect-site concentration, blood pressure, heart rate, and distributions and powers of the EEG spectrum were recorded in an awake state and under anesthesia. The EEG included seven bands: delta (0.5–3.5 Hz), theta (4.0–7.0 Hz), alpha-1 (7.5–9.5 Hz), alpha-2 (1
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Dempsey, Eugene M., Keith J. Barrington, Neil Marlow, et al. "Hypotension in Preterm Infants (HIP) randomised trial." Archives of Disease in Childhood - Fetal and Neonatal Edition 106, no. 4 (2021): 398–403. http://dx.doi.org/10.1136/archdischild-2020-320241.

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ObjectiveTo determine whether restricting the use of inotrope after diagnosis of low blood pressure (BP) in the first 72 hours of life affects survival without significant brain injury at 36 weeks of postmenstrual age (PMA) in infants born before 28 weeks of gestation.DesignDouble-blind, placebo-controlled randomised trial. Caregivers were masked to group assignment.Setting10 sites across Europe and Canada.ParticipantsInfants born before 28 weeks of gestation were eligible if they had an invasive mean BP less than their gestational age that persisted for ≥15 min in the first 72 hours of life a
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Singh, Pragya, Erica Mamauag, Deirdre Nolfi-Donegan, and Frederico Xavier. "Post-Immune Tolerance Induction Prophylactic FVIII Infusions May Not be Necessary for Tolerized Hemophilia a Patients on Emicizumab." Blood 142, Supplement 1 (2023): 5476. http://dx.doi.org/10.1182/blood-2023-179255.

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Background: Hemophilia A is a hereditary bleeding disorder characterized by low factor VIII (FVIII) activity. Patients with severe bleeding phenotypes are at risk for significant bleeding-related morbidity and mortality including the development of hemophilic arthropathy. In recent years, prophylaxis with emicizumab, a bispecific monoclonal antibody, has supplanted prophylactic FVIII infusions due to its ease of self-administration, long half-life, and low annual bleeding rate (ABR), independent of tolerization status to alloantibodies against FVIII (inhibitors). However, it is unclear if emic
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44

Blecha, Sebastian, Anna Hager, Verena Gross, et al. "Effects of Individualised High Positive End-Expiratory Pressure and Crystalloid Administration on Postoperative Pulmonary Function in Patients Undergoing Robotic-Assisted Radical Prostatectomy: A Prospective Randomised Single-Blinded Pilot Study." Journal of Clinical Medicine 12, no. 4 (2023): 1460. http://dx.doi.org/10.3390/jcm12041460.

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Objectives: Robotic-assisted laparoscopic prostatectomy (RALP) is typically conducted in steep Trendelenburg position (STP). The aim of the study was to evaluate whether crystalloid administration and individual management of positive end-expiratory pressure (PEEP) improve peri- and post-operative pulmonary function in patients undergoing RALP. Design: Prospective randomised single-centre single-blinded explorative study. Setting: Patients were either allocated to a standard PEEP (5 cmH2O) group or an individualised high PEEP group. Furthermore, each group was divided into a liberal and a rest
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Chophel, Ugyen. "Literature Review on Modeling of Integrated T&D System using Dynamic Phasor Technique." Zorig Melong | A Technical Journal of Science, Engineering and Technology 8, no. 1 (2025): 68–76. https://doi.org/10.17102/zmv8.i1.010.

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With the advent of transitioning from conventional to the modern structure of electrical power systems, the systems are prone to numerous electrical dynamics that no longer have the luxury to be neglected. As a result , the existing time domain simulation software, such as Electromagnetic Transient (EMT) and Root Mean Square (RMS) programs, are becoming inefficient for larger and complex systems. Moreover, the need for integrated Transmission and Distribution (iT&D) research is becoming an obvious trend with more distributed energy resources connecting to the system. The previous researche
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46

Galinsky, Robert, Simerdeep K. Dhillon, Christopher A. Lear, et al. "Magnesium sulfate and sex differences in cardiovascular and neural adaptations during normoxia and asphyxia in preterm fetal sheep." American Journal of Physiology-Regulatory, Integrative and Comparative Physiology 315, no. 2 (2018): R205—R217. http://dx.doi.org/10.1152/ajpregu.00390.2017.

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Magnesium sulfate (MgSO4) is recommended for preterm neuroprotection, preeclampsia, and preterm labor prophylaxis. There is an important, unmet need to carefully test clinical interventions in both sexes. Therefore, we aimed to investigate cardiovascular and neurophysiological adaptations to MgSO4 during normoxia and asphyxia in preterm male and female fetal sheep. Fetuses were instrumented at 98 ± 1 days of gestation (term = 147 days). At 104 days, unanesthetized fetuses were randomly assigned to intravenous MgSO4 ( n = 12 female, 10 male) or saline ( n = 13 female, 10 male). At 105 days fetu
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Takagi, Miki, Yasushi Tanaka, Yoshimitsu Yamasaki, et al. "Responsiveness of insulin-induced cardiac sympathetic nerve activation associates with blood pressure regulation in diabetics." American Journal of Physiology-Endocrinology and Metabolism 284, no. 5 (2003): E1022—E1026. http://dx.doi.org/10.1152/ajpendo.00169.2002.

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To quantitatively evaluate the effect of insulin on cardiac sympathetic nerve activity (SNA) and analyze clinical factors associated with insulin sensitivity for the regulation of SNA in diabetics, 29 Japanese type 2 diabetics without neuropathy were recruited. A 2-h control study and a 2-h hyperinsulinemic euglycemic glucose clamp study were performed. From the power spectral analysis of R-R intervals on ECG during both studies, two major components, the low-frequency (LF) and the high-frequency component (HF), were obtained. Then %LF was calculated as LF/(LF +HF), and the ratio of the averag
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Hubbard, J., W. E. A. Saad, S. S. Sabri, et al. "Rheolytic Thrombectomy with or without Adjunctive Indwelling Pharmacolysis in Patients Presenting with Acute Pulmonary Embolism Presenting with Right Heart Strain and/or Pulseless Electrical Activity." Thrombosis 2011 (December 28, 2011): 1–7. http://dx.doi.org/10.1155/2011/246410.

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Purpose. To evaluate the safety and efficacy of the Possis rheolytic thrombectomy with or without indwelling catheter-directed pharmacolysis for the treatment of massive pulmonary embolus in patients presenting with right heart strain and/or a pulseless electrical activity (PEA). Materials and Methods. Retrospective review of patients undergoing pulmonary pharmacolysis was performed (07/2004–06/2009). Pre- and posttreatment Miller index scoring weres calculated and compared. Patients were evaluated for tPA doses, ICU stay, hospital stay, and survival by Kaplan-Meier analysis. Results. 11 patie
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Shatzel, Joseph J., Jamie O. Lo, Kylee L. Martens, Thalia Padilla, Ashley E. Benson, and Monica Rincon. "Single-Dose IV Ferric Derisomaltose (1000mg given over 20 minutes) for the Treatment of Iron Deficiency Anemia in Pregnancy: A Prospective Interventional Clinical Trial (NCT05763043)." Blood 144, Supplement 1 (2024): 5256. https://doi.org/10.1182/blood-2024-206261.

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Background: Iron deficiency is a significant and prevalent health condition impacting nearly half of pregnant individuals globally. It is the leading cause of chronic disability in women, contributing to fatigue, diminished concentration, and adverse maternal and fetal outcomes during pregnancy and postpartum. Despite its high prevalence, oral iron repletion strategies in pregnancy often have limited efficacy and significant side effects. Intravenous (IV) iron formulations are more effective in restoring iron levels and have been shown to be safe during pregnancy but most are typically resourc
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Ordoudi, Stella A., Maria Papapostolou, Nikolaos Nenadis, Fani Th Mantzouridou, and Maria Z. Tsimidou. "Bay Laurel (Laurus nobilis L.) Essential Oil as a Food Preservative Source: Chemistry, Quality Control, Activity Assessment, and Applications to Olive Industry Products." Foods 11, no. 5 (2022): 752. http://dx.doi.org/10.3390/foods11050752.

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Essential oils (EOs) find application as flavoring agents in the food industry and are also desirable ingredients as they possess preservative properties. The Mediterranean diet involves the use of a lot of herbs and spices and their products (infusions, EOs) as condiments and for the preservation of foods. Application of EOs has the advantage of homogeneous dispersion in comparison with dry leaf use in small pieces or powder. Among them, Laurus nobilis (bay laurel) L. EO is an interesting source of volatiles, such as 1,8-cineole and eugenol, which are known for their preservative properties.
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