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Journal articles on the topic 'Mechanical properties of allografts'

Author: Grafiati

Published: 3 June 2025

Last updated: 31 July 2025

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1

Sacks, M. S., M. C. Jimenez Hamann, S. E. Otan˜no-Lata, and T. I. Malinin. "Local Mechanical Anisotropy in Human Cranial Dura Mater Allografts." Journal of Biomechanical Engineering 120, no. 4 (1998): 541–44. http://dx.doi.org/10.1115/1.2798027.

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Human cranial dura mater (CDM) allograft’s success as a repair biomaterial is partly due to its high mechanical strength, which facilitates its ability to form water-tight barriers and resist high in-vivo mechanical loads. Previous studies on CDM allograft mechanical behavior used large test specimens and concluded that the allograft was mechanically isotropic. However, we have quantified CDM microstructure using small angle light scattering (SALS) and found regions of well-aligned fibers displaying structural symmetry between the right and left halves (Jimenez et al., 1998). The high degree o

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2

Weber, Alexander E., Erik N. Mayer, Amit Nathani, et al. "How Variable Are Achilles Allografts Used for Anterior Cruciate Ligament Reconstruction? A Biomechanical Study." American Journal of Sports Medicine 46, no. 8 (2018): 1870–76. http://dx.doi.org/10.1177/0363546518768780.

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Background: Allograft tendon used in anterior cruciate ligament reconstruction (ACLR) requires sterilization before implantation. Low-dose gamma irradiation is a means of sterilization that may minimize tissue damage. Purpose: To quantify the variability in mechanical properties between low-dose irradiated Achilles tendon allografts used for ACLR. Study Design: Descriptive laboratory study. Methods: A total of 15 intact outer-third Achilles tendon allograft specimens were collected from the remains of full Achilles allografts used for intraoperative ACLR at a single hospital. All grafts were o

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3

Kovács, Gergely Imre, László Hidi, Evelin Forró, et al. "Multi-Scale Mechanics of Cryopreserved Human Arterial Allografts Across a Six-Month Period." Journal of Functional Biomaterials 16, no. 6 (2025): 198. https://doi.org/10.3390/jfb16060198.

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Operating under septic conditions poses significant challenges in vascular surgery. Infection is a serious risk when handling synthetic vessel prostheses and is one of the most dreaded complications. In the event of graft infection, an infection-resistant alternative is necessary. Cryopreserved vascular allografts offer a suitable alternative to replace an infected vessel or a section of a synthetic graft. However, there are no international guidelines for the preparation, storage, and thawing of such vessel grafts. Here, we aimed to investigate the mechanical properties of human cryopreserved

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4

Guillaume, Villatte, Erivan Roger, Cueff Regis, Wittrant Yohann, Boisgard Stéphane, and Descamps Stéphane. "Evaluation of the biomechanical and structural properties of bone allografts treated with a new cleaning process." World Journal of Advanced Research and Reviews 14, no. 3 (2022): 608–16. https://doi.org/10.5281/zenodo.7732961.

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The use of allograft bone is becoming increasingly common. The intrinsic mechanical and structural properties of the graft are of major importance for osseointegration. Current cleaning treatments using chemical or physical products increase biosafety but may disturb these bone characteristics. A new cleaning treatment for cancellous and cortical bone by simple mechanical washing (sonication and centrifugation) and supercritical carbon dioxide (scCO2) treatment was developed. The mechanical and structural properties of allografts cleaned with this treatment were compared with those obtained af

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Wang, Jinping, Haixiang Zhang, Yang Sun, Pengfei Liu, Shuqin Li, and Pengcheng Cui. "Mechanical properties of de-epithelialized tracheal allografts." Journal of Thoracic Disease 13, no. 2 (2021): 1066–74. http://dx.doi.org/10.21037/jtd-20-2739.

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6

Wisnewski, Paul J., Dennis L. Powers, and John M. Kennedy. "Glutaraldehyde-Cross-linked Meniscal Allografts: Mechanical Properties." Journal of Investigative Surgery 1, no. 4 (1988): 259–66. http://dx.doi.org/10.3109/08941938809141091.

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7

Kubíková, Tereza, Petra Kochová, Radovan Fiala, et al. "Histological Composition and Mechanical Properties of Cryopreserved Samples of Aortic and Pulmonary Valves." Solid State Phenomena 258 (December 2016): 341–44. http://dx.doi.org/10.4028/www.scientific.net/ssp.258.341.

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Human cryopreserved allografts of pulmonary and aortic valves are routinely used as total valve replacement. For successful surgery it is needed to sufficiently preserve biomechanical properties and histological structures of allografts. However, it is not known how the mechanical properties of these allografts relate to their histological composition. The aim of our study was to compare the histological composition and mechanical properties of the valves. From allografts we prepared 2 valve cusps and samples of aorta or pulmonary trunk. In a previous study we had measured following parameters

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8

Yanke, Adam, Rebecca Bell, Andrew Lee, Elizabeth F. Shewman, Vincent Wang, and Bernard R. Bach. "Regional mechanical properties of human patellar tendon allografts." Knee Surgery, Sports Traumatology, Arthroscopy 23, no. 4 (2013): 961–67. http://dx.doi.org/10.1007/s00167-013-2768-5.

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9

Snetkov, A. I., M. V. Lekishvili, M. A. Kasymov, et al. "Application of Plastic Material «Perfoost» in Children with Bone Pathology." N.N. Priorov Journal of Traumatology and Orthopedics 10, no. 4 (2003): 74–79. http://dx.doi.org/10.17816/vto200310474-79.

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Osseous-plastic material «Perfoost» - demineralized lyophilized perforated allografs- was elaborated at CITO in 1997. Study of mechanical characteristics showed that «Perfoost» grafts had high plasticity. Mechanical stiffness allowed to use that material for substitution of marginal bone defects. Study in vitro showed high efficacy of cloning that was indirect evidence that demineralized allografts had osteoinductive properties. Between 1998-2002 at the Department of bone pathology for children and adolescents 121 patients, aged 1-18, with primary tumor, tumor-like diseases and systemic inheri

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10

Nuffer, Alicia, Robin Evrard, Thomas Schubert, et al. "Surgical mechanical properties of perfused decellularized massive bone allografts: An comparative in vivo test." PLOS One 20, no. 6 (2025): e0322901. https://doi.org/10.1371/journal.pone.0322901.

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Massive bone allograft decellularized by perfusion is a solution for large bone defect reconstructions. Perfusion-based decellularization offers a solution by removing cellular components while preserving the non-immunogenic matrix. This study evaluates the in vivo integration and mechanical properties of perfusion-decellularized bone grafts compared to “fresh-frozen” grafts, both before implantation and after explantation. Standardized porcine femoral grafts were categorized into non-irradiated, irradiated, and explanted groups, with half undergoing perfusion decellularization. Biomechanical

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11

Smith, C. W., I. S. Young, and J. N. Kearney. "Mechanical Properties of Tendons: Changes With Sterilization and Preservation." Journal of Biomechanical Engineering 118, no. 1 (1996): 56–61. http://dx.doi.org/10.1115/1.2795946.

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Tendon allografts are commonly used to replace damaged anterior cruciate ligaments (ACL). Some of the sterilization and preservation techniques used by tissue banks with tendon allografts are thought to impair the mechanical properties of graft tissues. The tensile mechanical properties of porcine toe extensor tendons were measured using a dynamic testing machine following either freezing, freeze-drying, freezing then irradiation at 25 kGy (2.5 MRad), freeze-drying then irradiation, or freeze-drying then ethylene oxide gas sterilization. There was a small but significant difference in Young’s

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12

Jones, David B., Paul M. Huddleston, Mark E. Zobitz, and Michael J. Stuart. "Mechanical Properties of Patellar Tendon Allografts Subjected to Chemical Sterilization." Arthroscopy: The Journal of Arthroscopic & Related Surgery 23, no. 4 (2007): 400–404. http://dx.doi.org/10.1016/j.arthro.2006.11.031.

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Walker, Mary M., Molly E. Baumann, John H. Alexander, et al. "Mechanical strain induces ex vivo expansion of periosteum." PLOS ONE 17, no. 12 (2022): e0279519. http://dx.doi.org/10.1371/journal.pone.0279519.

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Segmental bone defects present complex clinical challenges. Nonunion, malunion, and infection are common sequalae of autogenous bone grafts, allografts, and synthetic bone implants due to poor incorporation with the patient’s bone. The current project explores the osteogenic properties of periosteum to facilitate graft incorporation. As tissue area is a natural limitation of autografting, mechanical strain was implemented to expand the periosteum. Freshly harvested, porcine periosteum was strained at 5 and 10% per day for 10 days with non-strained and free-floating samples serving as controls.

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14

Conrad, Bryan P., Matthew Rappé, MaryBeth Horodyski, Kevin W. Farmer, and Peter A. Indelicato. "The effect of sterilization on mechanical properties of soft tissue allografts." Cell and Tissue Banking 14, no. 3 (2012): 359–66. http://dx.doi.org/10.1007/s10561-012-9340-2.

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15

Xiong, Zhuang, Léa Rouquier, Christine Chappard, et al. "A New Microarchitecture-Based Parameter to Predict the Micromechanical Properties of Bone Allografts." Materials 16, no. 9 (2023): 3349. http://dx.doi.org/10.3390/ma16093349.

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Scaffolds are an essential component of bone tissue engineering. They provide support and create a physiological environment for cells to proliferate and differentiate. Bone allografts extracted from human donors are promising scaffolds due to their mechanical and structural characteristics. Bone microarchitecture is well known to be an important determinant of macroscopic mechanical properties, but its role at the microscopic, i.e., the trabeculae level is still poorly understood. The present study investigated linear correlations between microarchitectural parameters obtained from X-ray comp

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Garoufalis, Matthew, Darshan Nagesh, Patrick J. Sanchez, et al. "Use of Dehydrated Human Amnion/Chorion Membrane Allografts in More Than 100 Patients with Six Major Types of Refractory Nonhealing Wounds." Journal of the American Podiatric Medical Association 108, no. 2 (2018): 84–89. http://dx.doi.org/10.7547/17-039.

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Background: Biochemical properties of the amniotic membrane help modulate inflammation and enhance soft-tissue healing. In controlled trials, the efficacy of dehydrated human amnion/chorion membrane (dHACM) allografts has been established. Our purpose is to describe our experience with using dHACM to treat nonhealing wounds of various etiologies. Methods: We conducted a retrospective review of deidentified data from 117 consecutive patients treated in an outpatient clinic with dHACM allografts with wounds of various etiologies over 2 years. The decision to use advanced wound-care treatments is

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Vorontsov, Petro, Nataliya Ashukina, Valentyna Maltseva, Zinaida Danуshchuk, Olga Nikolchenko, and Kateryna Samoylova. "HISTOLOGICAL EVALUATION OF REPARATIVE OSTEOGENESIS IN CRITICAL SIZE FEMORAL BONE DEFECTS IN RATS OF DIFFERENT AGES AFTER INTRODUCTION OF ALLOGRAFTS SATURATED WITH BLOOD PLASMA GROWTH FACTORS." ORTHOPAEDICS TRAUMATOLOGY and PROSTHETICS, no. 2 (June 27, 2023): 25–32. http://dx.doi.org/10.15674/0030-59872023225-32.

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The increase in injuries and gunshot wounds because of the war in Ukraine makes it imperative to find methods for optimizing bone regeneration and filling large-size bone defects. Aim. Study morphological features of reparative osteogenesis when critical size femoral bone defects in rats in the early reproductive and mature stages are filled with allografts saturated with blood plasma growth factors (GF). Methods. Defects (3 × 3 mm) were created in the distal femoral metaphysis of 60 white laboratory rats, 3-months-old (n = 30) and 12-months-old (n = 30). The defects were filled with bone allo

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18

Guo, MZ, ZS Xia, and LB Lin. "The mechanical and biological properties of demineralised cortical bone allografts in animals." Journal of Bone and Joint Surgery. British volume 73-B, no. 5 (1991): 791–94. http://dx.doi.org/10.1302/0301-620x.73b5.1894668.

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19

Gehrke, Sergio, Patricia Mazón, Leticia Pérez-Díaz, et al. "Study of Two Bovine Bone Blocks (Sintered and Non-Sintered) Used for Bone Grafts: Physico-Chemical Characterization and In Vitro Bioactivity and Cellular Analysis." Materials 12, no. 3 (2019): 452. http://dx.doi.org/10.3390/ma12030452.

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In this work, the physicochemical properties and in vitro bioactivity and cellular viability of two commercially available bovine bone blocks (allografts materials) with different fabrication processes (sintered and not) used for bone reconstruction were evaluated in order to study the effect of the microstructure in the in vitro behavior. Scanning electron microscopy, X-ray diffraction, Fourier transform infrared spectrometry, mechanical resistance of blocks, mercury porosimetry analysis, in vitro bioactivity, and cell viability and proliferation were performed to compare the characteristics

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20

Koudelka, Petr, Tomáš Doktor, Daniel Kytyr, Nela Fenclova, Josef Sepitka, and Jaroslav Lukes. "Micromechanical Properties of Biocompatible Materials for Bone Tissue Engineering Produced by Direct 3D Printing." Key Engineering Materials 662 (September 2015): 138–41. http://dx.doi.org/10.4028/www.scientific.net/kem.662.138.

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Bone implants in form of artificial scaffolds manufactured from poly-lactic acid (PLA) represent an attractive alternative to traditional surgical treatments of defective bones (i.e. autografts and allografts). In this work factors influencing biocompatibility and primary stability of implants manufactured from PLA using direct 3D printing were assessed using nanoindentation. For this reason bulk sample of the PLA material and a printed object were subjected to nanomechanical measurement. Quasi-static nanoindentation was employed to identify elastic modulus and hardness distribution on surface

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21

Arutyunyan, Marietta, and Berik Tuleubayev. "Impregnation of a Bone Marrow Allograft with an Antibiotic Prepared According to the Marburg System, an Original Method." Research Institute of Traumatology and Orthopedics 1, no. 56 (2021): 25–31. http://dx.doi.org/10.52889/1684-9280-2021-1-56-25-31.

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The aim: To develop an original method of antibiotic impregnation of bone allograft prepared according to the Marburg bone bank system. Methods. The work was divided into three parts (as part of an experimental study). The first part of the study included the collection and preparation of bone allograft, which was carried out on the basis of the Hospital named after professor Makazhanov, where the femoral heads were harvested, removed during arthroplasty and heat-treated according to the Marburg system of the bone bank. The second stage of the study was to select the optimal antibacterial drug

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22

Berberi, Antoine, Malkan Abdrashidova Amkhadova, Antoine Samarani, and Georges Aoun. "PHYSICOCHEMICAL CHARACTERIZATION: COMPARATIVE EVALUATION OF ALLOGRAFT BIOMATERIALS AND AUTOGENOUS BONE." Russian Journal of Dentistry 21, no. 5 (2017): 233–37. http://dx.doi.org/10.18821/1728-2802-2017-21-5-233-237.

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Objectives: bone substitutes used in oral surgery include allografts, xenografts and synthetic materials that are frequently used to compensate bone loss or to reinforce repaired bone by encouraging new bone ingrowth into the defect site. The aim of this study was to evaluate a number ofphysical and chemical properties in a variety of allografts biomaterials used in oral surgery and to compare them with those of autogenous bone. Materials and methods: autogenous bone andfive different allograft biomaterials were studied by high-resolution X-ray diffractometry, atomic absorption spectrometry, l

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Putzer, David, Christoph Gert Ammann, Débora Coraça-Huber, Ricarda Lechner, Werner Schmölz, and Michael Nogler. "The Influence of Liquids on the Mechanical Properties of Allografts in Bone Impaction Grafting." Biopreservation and Biobanking 15, no. 5 (2017): 410–16. http://dx.doi.org/10.1089/bio.2017.0003.

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Vyrva, O. E., Ya O. Golovina, R. V. Malik, M. Yu Karpinsky, and O. D. Karpinska. "Studying the strength of the tibia during the replacement of a post-resection defect with a segmental allograft using locked intramedullary nailing (experimental clinical study)." TRAUMA 22, no. 5 (2022): 25–32. http://dx.doi.org/10.22141/1608-1706.5.22.2021.244464.

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Background. To achieve success in the incorporation of allografts and bone of the recipient, many factors are taken into account, which can be divided into two main groups: those related to sterilization and processing of the bone allograft and factors affecting the reliability of implant fixation in the bone of the recipient. The second important factor is the method for fixing the allografts and the bone of the recipient. The purpose was to determine the mechanical properties of bone after segmental bone alloplasty. Materials and methods. Female patient Sh., 30 years old, diagnosed with oste

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Sun, Yikan, Vedran Lovric, Tian Wang, Rema A. Oliver, and William R. Walsh. "Effects of SCCO2, Gamma Irradiation, and Sodium Dodecyl Sulfate Treatments on the Initial Properties of Tendon Allografts." International Journal of Molecular Sciences 21, no. 5 (2020): 1565. http://dx.doi.org/10.3390/ijms21051565.

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Sterile and decellularized allograft tendons are viable biomaterials used in reconstructive surgeries for dense connective tissue injuries. Established allograft processing techniques including gamma irradiation and sodium dodecyl sulfate (SDS) can affect tissue integrity. Supercritical carbon dioxide (SCCO2) represents a novel alternative that has the potential to decellularize and sterilize tendons with minimized exposure to denaturants, shortened treatment time, lack of toxic residues, and superior tissue penetration, and thus efficacy. This study attempted to develop a single-step hybrid d

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Zobitz, M. E., P. M. Huddleston, and D. B. Jones. "Effect of chemical sterilization on mechanical properties of human cortical bone and patellar tendon allografts." Journal of Biomechanics 39 (January 2006): S472. http://dx.doi.org/10.1016/s0021-9290(06)84926-2.

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Vastel, L., A. Meunier, H. Siney, L. Sedel, and J. P. Courpied. "Effect of different sterilization processing methods on the mechanical properties of human cancellous bone allografts." Biomaterials 25, no. 11 (2004): 2105–10. http://dx.doi.org/10.1016/j.biomaterials.2003.08.067.

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Lee, Kwang Il, Jung Soo Lee, Kyoung Tak Kang, et al. "In Vitro and In Vivo Performance of Tissue-Engineered Tendons for Anterior Cruciate Ligament Reconstruction." American Journal of Sports Medicine 46, no. 7 (2018): 1641–49. http://dx.doi.org/10.1177/0363546518759729.

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Background: Anterior cruciate ligament (ACL) reconstruction is the current standard of care for ACL tears. However, the results are not consistently successful; autografts or allografts have certain disadvantages; and synthetic grafts have had poor clinical results. Purpose: To determine if recellularization of decellularized tendons combined with mechanical stimulation in a bioreactor could replicate the mechanical properties of the native ACL and be successfully used for ACL reconstruction in vivo. Study Design: Controlled laboratory study. Methods: Porcine tibialis tendons were decellulariz

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Jackson, D. W., E. S. Grood, P. Wilcox, D. L. Butler, T. M. Simon, and J. P. Holden. "The effects of processing techniques on the mechanical properties of bone-anterior cruciate ligament-bone allografts." American Journal of Sports Medicine 16, no. 2 (1988): 101–5. http://dx.doi.org/10.1177/036354658801600203.

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Schimizzi, Aimee, Michelle Wedemeyer, Tim Odell, Walter Thomas, Andrew T. Mahar, and Robert Pedowitz. "Effects of a Novel Sterilization Process on Soft Tissue Mechanical Properties for Anterior Cruciate Ligament Allografts." American Journal of Sports Medicine 35, no. 4 (2007): 612–16. http://dx.doi.org/10.1177/0363546506295083.

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Bordet, Marine, Guilhem Rival, Laurence Seveyrat, et al. "Storage of human arterial allografts at +2/+8°C: impact on the 12-month mechanical properties." Annals of Vascular Surgery 116 (July 2025): 149–50. https://doi.org/10.1016/j.avsg.2025.04.006.

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32

Faragó, Dénes, Atilla F. Karácsony, Zsanett Orlovits, Karoly Pap, and Rita M. Kiss. "Changes in the mechanical properties of tibialis anterior and peroneus longus allograft depending on sterilization method and storage time." Bone & Joint Research 14, no. 3 (2025): 270–80. https://doi.org/10.1302/2046-3758.143.bjr-2024-0129.r2.

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AimsThe aim of the present research was to analyze the effects of different sterilization methods and storage times on the mechanical properties (load at first break, strain at first break, maximum load, strain at maximum load, and Young’s modulus of elasticity) of different allografts compared to native groups.MethodsTwo types of grafts were harvested from human cadavers: 165 tibialis anterior (TA) and 166 peroneus longus (PL) tendons. According to the two types of sterilization methods (γ and electron beam irradiation) or the lack of one, and the six types of storage time (one to six months)

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Madhavarapu, Shreya, Rohit Rao, Sarah Libring, Emma Fleisher, Yasonia Yankannah, and Joseph W. Freeman. "Design and characterization of three-dimensional twist-braid scaffolds for anterior cruciate ligament regeneration." TECHNOLOGY 05, no. 02 (2017): 98–106. http://dx.doi.org/10.1142/s2339547817500066.

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The anterior cruciate ligament (ACL) is the most commonly injured ligament in the knee, with more than 350,000 ACL injuries reported annually in the US. Current treatments include the use of autografts and allografts, which have a number of disadvantages. Previous attempts to use synthetic materials in ligament replacement have been unsuccessful due to their inability to replicate the long-term mechanical properties of the native ligament. The focus of this study was to develop twist-braid poly(L-lactic acid) (PLLA) scaffolds for ACL regeneration. Poly(ethylene glycol) diacrylate (PEGDA) was i

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Ma'ruf, Mochammad Taha. "Bioactive Glass Fiber-Reinforced Composite For Bone Regeneration." Odonto : Dental Journal 12, no. 1 (2025): 113. https://doi.org/10.30659/odj.12.1.113-126.

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Background: Bone regeneration remains a critical challenge in tissue engineering, with current solutions such as autografts and allografts facing limitations in availability, cost, and biocompatibility. Bioactive glass fiber-reinforced composites (BGFRC) have emerged as a promising alternative, combining the bioactivity of bioactive glass with the mechanical strength of fiber-reinforced materials.Methods: This literature review synthesizes findings from 46 recent journal articles and books on bioactive glass, bioactive glass fibers, and BGFRC. The review focuses on material composition, mechan

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Manoj, Tyagi, Tyagi Manali, Vashundhara, and Rajkumar. "Evaluating the Role of Bone Grafts and Synthetic Substitutes in Enhancing Fracture Healing: A Systematic Review." International Journal of Pharmaceutical and Clinical Research 16, no. 12 (2024): 1043–48. https://doi.org/10.5281/zenodo.14600218.

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Fracture healing is a complex biological process that often requires intervention to achieve optimal outcomes, particularly in extensive bone loss or non-union cases. Bone grafts, including autografts and allografts, along-side synthetic substitutes such as calcium-based ceramics, bioactive glass, and biomaterials, are integral to mod-ern orthopaedic practice. Autografts remain the gold standard due to their osteogenic, osteoinductive, and oste-oconductive properties, although donor site morbidity and limited availability are significant constraints. Allo-grafts offer a scalable alternative bu

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Bursac, Predrag, Amanda York, Paulette Kuznia, Lauren M. Brown, and Steven P. Arnoczky. "Influence of Donor Age on the Biomechanical and Biochemical Properties of Human Meniscal Allografts." American Journal of Sports Medicine 37, no. 5 (2009): 884–89. http://dx.doi.org/10.1177/0363546508330140.

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Background Although the use of meniscal allografts to replace severely damaged or absent menisci is commonplace, little is known about the effects of donor age on the biochemical and biomechanical properties of human menisci. Hypothesis The mechanical and biochemical properties of human medial and lateral menisci from donors less than 45 years of age do not vary with donor age. Study Design Controlled laboratory study. Methods Thirty-three lateral and 25 medial menisci from 34 donors (26 male and 8 female) ranging from 15 to 44 years of age were harvested and immediately stored at —80°C. The o

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Vastel, L., C. Masse, E. Crozier, et al. "Effects of gamma irradiation on mechanical properties of defatted trabecular bone allografts assessed by speed-of-sound measurement." Cell and Tissue Banking 8, no. 3 (2007): 205–10. http://dx.doi.org/10.1007/s10561-006-9030-z.

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Gibbons, M. J., D. L. Butler, E. S. Grood, D. I. Bylski-Austrow, M. S. Levy, and F. R. Noyes. "Effects of gamma irradiation on the initial mechanical and material properties of goat bone-patellar tendon-bone allografts." Journal of Orthopaedic Research 9, no. 2 (1991): 209–18. http://dx.doi.org/10.1002/jor.1100090209.

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Christie, Grant W., and Brian G. Barratt-Boyes. "Biaxial mechanical properties of explanted aortic allograft leaflets." Annals of Thoracic Surgery 60 (August 1995): S160—S164. http://dx.doi.org/10.1016/0003-4975(95)00259-n.

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40

Schätzlein, Eva, Christoph Kicker, Nicolas Söhling, et al. "3D-Printed PLA-Bioglass Scaffolds with Controllable Calcium Release and MSC Adhesion for Bone Tissue Engineering." Polymers 14, no. 12 (2022): 2389. http://dx.doi.org/10.3390/polym14122389.

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Large bone defects are commonly treated by replacement with auto- and allografts, which have substantial drawbacks including limited supply, donor site morbidity, and possible tissue rejection. This study aimed to improve bone defect treatment using a custom-made filament for tissue engineering scaffolds. The filament consists of biodegradable polylactide acid (PLA) and a varying amount (up to 20%) of osteoconductive S53P4 bioglass. By employing an innovative, additive manufacturing technique, scaffolds with optimized physico-mechanical and biological properties were produced. The scaffolds fe

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Alharbi, N., Shah Fenner Khan, O. Bretcanu, and K. W. Dalgarno. "Processing of Apatite-Wollastonite (AW) Glass-Ceramic for Three Dimensional Printing (3DP)." Applied Mechanics and Materials 754-755 (April 2015): 974–78. http://dx.doi.org/10.4028/www.scientific.net/amm.754-755.974.

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Apatite-wollastonite glass ceramics (AW) in bone regeneration and replacement applications have been seen as a favourable alternative to allografts and autografts. A-W has good biocompatibility, bioactivity, chemical stability and mechanical properties. In this study AW was used to fabricate 3D parts for bone applications by an indirect three dimensional printing (3DP) technique. Various powder blends of AW and maltodextrine (MD) were processed using the Z Corp 3D printing process, with two different liquid binder systems. The green parts were post-processed through using a heat treatment to b

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Paola, Saskia Castañeda Anaya, and Alan Mendoza Sánchez Héctor. "Comparison between the Different Types of Tendon Grafts in Reconstructive Surgery." INTERNATIONAL JOURNAL OF MEDICAL SCIENCE AND CLINICAL RESEARCH STUDIES 03, no. 08 (2023): 1551–53. https://doi.org/10.5281/zenodo.8224245.

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Tendon grafts play a crucial role in reconstructive surgery, restoring function and stability to damaged tendons. This literature review examines the theoretical framework, surgical treatment, and potential complications associated with different types of tendon grafts. Autografts, harvested from the patient's own body, are considered the gold standard due to their biocompatibility and better integration. Allografts and synthetic grafts offer alternatives, eliminating donor site morbidity and providing consistent biomechanical properties. However, considerations include the risk of graft r

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Salmasi, Shima, Leila Nayyer, Alexander M. Seifalian, and Gordon W. Blunn. "Nanohydroxyapatite Effect on the Degradation, Osteoconduction and Mechanical Properties of Polymeric Bone Tissue Engineered Scaffolds." Open Orthopaedics Journal 10, no. 1 (2016): 900–919. http://dx.doi.org/10.2174/1874325001610010900.

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BACKGROUNDStatistical reports show that every year around the world approximately 15 million bone fractures occur; of which up to 10% fail to heal completely and hence lead to complications of non-union healing. In the past, autografts or allografts were used as the “gold standard” of treating such defects. However, due to various limitations and risks associated with these sources of bone grafts, other avenues have been extensively investigated through which bone tissue engineering; in particular engineering of synthetic bone graft substitutes, has been recognised as a promising alternative t

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Vinicius Beserra dos Santos, Marcus, Lorenna Bastos Nogueira Rocha, Ewerton Gomes Vieira, et al. "Development of Composite Scaffolds Based on Cerium Doped-Hydroxyapatite and Natural Gums—Biological and Mechanical Properties." Materials 12, no. 15 (2019): 2389. http://dx.doi.org/10.3390/ma12152389.

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Hydroxyapatite (HAp) is a ceramic material composing the inorganic portion of bones. Ionic substitutions enhance characteristics of HAp, for example, calcium ions (Ca2+) by cerium ions (Ce3+). The use of HAp is potentialized through biopolymers, cashew gum (CG), and gellan gum (GG), since CG/GG is structuring agents in the modeling of structured biocomposites, scaffolds. Ce-HApCG biocomposite was synthesized using a chemical precipitation method. The obtained material was frozen (–20 °C for 24 h), and then vacuum dried for 24 h. The Ce-HApCG was characterized by X-Ray diffractograms (XRD), X-r

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Balsly, Colleen R., Andrew T. Cotter, Lisa A. Williams, Barton D. Gaskins, Mark A. Moore, and Lloyd Wolfinbarger. "Effect of low dose and moderate dose gamma irradiation on the mechanical properties of bone and soft tissue allografts." Cell and Tissue Banking 9, no. 4 (2008): 289–98. http://dx.doi.org/10.1007/s10561-008-9069-0.

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Thornton, Gail M., Xinxin Shao, Marielle E. Kuchison, Linda L. Marchuk, Nigel G. Shrive, and Cyril B. Frank. "Healing ligament mechanical properties are improved by repair with interpositional allografts but not by concomitant treatment with hyaluronic acid." Journal of Orthopaedic Research 27, no. 3 (2008): 400–407. http://dx.doi.org/10.1002/jor.20776.

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Fitzpatrick, John C., Peter M. Clark, and Franco M. Capaldi. "Effect of Decellularization Protocol on the Mechanical Behavior of Porcine Descending Aorta." International Journal of Biomaterials 2010 (2010): 1–11. http://dx.doi.org/10.1155/2010/620503.

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Enzymatic-detergent decellularization treatments may use a combination of chemical reagents to reduce vascular tissue to sterilized scaffolds, which may be seeded with endothelial cells and implanted with a low risk of rejection. However, these chemicals may alter the mechanical properties of the native tissue and contribute to graft compliance mismatch. Uniaxial tensile data obtained from native and decellularized longitudinal aortic tissue samples was analyzed in terms of engineering stress and fit to a modified form of the Yeoh rubber model. One decellularization protocol used SDS, while th

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Rosero-Alzate, Érika Lorena, Miguel Ángel Zapata-Pernett, Duvan Vega-Ortiz, et al. "Influence of porosity on the biomimetic growing patterns of bonelike apatite on the surface of calcium phosphate – calcium titanate – alumina compounds." DYNA 88, no. 218 (2021): 24–33. http://dx.doi.org/10.15446/dyna.v88n218.91651.

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Biomaterials are increasingly used for bone tissue regeneration because of their potential to overcome the morbidity caused by autologous bone grafts and allografts. A combination of properties is required, as biocompatibility, osteoconductivity, good mechanical strength and fracture toughness. In this research, a compound of alumina matrix with calcium titanate and calcium phosphate is proposed. Magnesium stearate was used as porogen agent. The aim of this research was to evaluate the effect of porosity on the crystalline phases formed, as well as the growing pattern and types of calcium phos

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Goertzen, MJ, H. Clahsen, KF Burrig, and KP Schulitz. "Sterilisation of canine anterior cruciate allografts by gamma irradiation in argon. Mechanical and neurohistological properties retained one year after transplantation." Journal of Bone and Joint Surgery. British volume 77-B, no. 2 (1995): 205–12. http://dx.doi.org/10.1302/0301-620x.77b2.7706332.

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Salehpour, A., D. L. Butler, F. S. Proch, et al. "Dose-dependent response of gamma irradiation on mechanical properties and related biochemical composition of goat bone-patellar tendon-bone allografts." Journal of Orthopaedic Research 13, no. 6 (1995): 898–906. http://dx.doi.org/10.1002/jor.1100130614.

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