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Dissertations / Theses on the topic 'Mechanism of action of drugs'

Author: Grafiati

Published: 5 June 2025

Last updated: 2 August 2025

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1

Matkar, Smita S. "Mechanism of action of potential anticancer drugs." Scholarly Commons, 2008. https://scholarlycommons.pacific.edu/uop_etds/2368.

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Traditionally, inoperable or metastatic cancers have been treated by causing massive DNA damage in order to induce self-destruction (apoptosis) of the rapidly multiplying cancer cells. Initially, this strategy works for many cancers, in particular those which express normal p53 tumor suppressor protein. However, most cancers eventually aquire mutations in either p53 or other signaling molecules and fail to initiate apoptosis in response to severe DNA damage. During this study three types of compounds were investigated for their DNA damaging and anticancer effects: a pair of novel metal contain

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2

Kelland, Lloyd R. "Antitumour and mechanism of action studies with novel cancer drugs." Thesis, University of Bath, 2000. https://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.760737.

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3

Beverly, Bart J. "Mechanism of action of aurothioalkyl antiarthritic drugs : role of myeloproxidase /." The Ohio State University, 1987. http://rave.ohiolink.edu/etdc/view?acc_num=osu1487330761219101.

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4

Elayadi, Anissa N. "Metabolism and mechanism of action of acylfulvenes, novel antitumor drugs /." Diss., Connect to a 24 p. preview or request complete full text in PDF format. Access restricted to UC campuses, 1999. http://wwwlib.umi.com/cr/ucsd/fullcit?p9952666.

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5

CONSONNI, ELISA. "Anticancer drugs mechanism of action investigated by advanced biomolecular tools." Doctoral thesis, Università degli Studi di Milano, 2005. http://hdl.handle.net/2434/61944.

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Pixantrone (BBR2778), a DNA intercalating agent topoisomerase II inhibitor, belongs to the aza-anthracenedione chemical class and is currently under clinical investigation in non-dgkn iymphomas (NHLs)

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6

Christie, Andrew W. "Mechanism of action of selected anti-lipolytic agents in adipocytes." Thesis, University of Newcastle Upon Tyne, 1995. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.282761.

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7

Chen, Yu. "Mechanism of action of platinum anticancer drugs : from kinetic to structural studies." Thesis, University of Edinburgh, 1999. http://hdl.handle.net/1842/14521.

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Cisplatin, <I>cis</I>-[Pt(NH<SUB>3</SUB>)<SUB>2</SUB>Cl<SUB>2</SUB>], has been a successful and most widely used anticancer drug since its first discovery 30 years ago. Up to now the mechanism of action of this drug is still not well understood. In this thesis, pH dependent platinum-sulfur interactions, the solution structure of cisplatin DNA GpG intrastrand adduct and the chemistry of a new anticancer active drug have been investigated. Using [<SUP>1</SUP>H, <SUP>15</SUP>N] 2D NMR spectroscopy and HPLC, together with <SUP>15</SUP>N-labelled amine ligands highly pH dependent interconversion be

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8

Di, Daniel Elena. "Mechanisms of action of mood-stabilizing drugs." Thesis, University College London (University of London), 2007. http://discovery.ucl.ac.uk/1445413/.

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Bipolar disorder or manic-depression is a severe and common psychiatric illness that is often treated with mood-stabilizing drugs. Several molecular targets and signalling pathways have been implicated in the pathophysiology of the illness and in the mechanism of action of these drugs. However, the precise targets that are responsible for the therapeutic action and side-effects of the drugs are not known. In this PhD thesis we have analysed some of the potential drug targets, in particular extracellular signal-regulated kinase mitogen-activated protein kinase (ERK/MAPK) and glycogen synthase k

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9

Chan, Wing Chi. "Chemical studies on mechanism of action of the Chinese antimalarial artemisinin and its derivatives /." View abstract or full-text, 2005. http://library.ust.hk/cgi/db/thesis.pl?CHEM%202005%20CHAN.

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10

Teran, Claudia. "Efficacy and Mechanism of Action of a Novel Class of Antic-Cancer Drugs." Thesis, Université d'Ottawa / University of Ottawa, 2016. http://hdl.handle.net/10393/34412.

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The incidence of cancer worldwide has increased over the years, and gastrointestinal cancers (G.I.) are amongst the most common forms of cancer. Nevertheless, there is still no curative treatments for this group of tumors. Nucleoside analogues are widely used in cancer treatment. The prevailing compounds are Gemcitabine (used for pancreatic cancer and other carcinomas), 5-Fluorouracil (used in breast, colon, and other cancers), Cytarabine and Clofarabine (used in leukemias). Gemcitabine, the current standard of care for various forms of solid tumors, has a limited efficacy against pancreatic c

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11

Gruber, Susanne H. M. "Novel mechanism of action of antipsychotic drugs : effects on neuropeptides in rat brain /." Stockholm : [Karolinska institutets bibliotek], 2002. http://diss.kib.ki.se/2002/91-7349-229-9.

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12

Purfield, Anne Elizabeth Meshnick Steven R. "A mechanism of resistance and mode of action for drugs against Plasmodium falciparum." Chapel Hill, N.C. : University of North Carolina at Chapel Hill, 2007. http://dc.lib.unc.edu/u?/etd,1398.

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Thesis (Ph. D.)--University of North Carolina at Chapel Hill, 2007.<br>Title from electronic title page (viewed Apr. 25, 2008). "... in partial fulfillment of the requirements for the degree of Doctor of Philosophy in the Department of Microbiology and Immunology." Discipline: Microbiology and Immunology; Department/School: Medicine.

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13

Lohmeyer, Matthias. "The mechanism of action of antitumour lipid agents related to platelet-activating factor (PAF)." Thesis, University of Cambridge, 1994. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.319528.

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14

Mungthin, Mathirut. "Studies on the mechanism of action and mechanism of resistance to quinoline-containing antimalarial drugs in Plasmodium falciparum." Thesis, University of Liverpool, 1998. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.263874.

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15

Rickardson, Linda. "New Methods to Screen for Cancer Drugs and to Evaluate their Mechanism of Action." Doctoral thesis, Uppsala University, Clinical Pharmacology, 2008. http://urn.kb.se/resolve?urn=urn:nbn:se:uu:diva-8440.

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<p>Cancer is a common disease and due to problems with resistance against cancer drugs and the limited benefit from chemotherapy in many diagnoses, there is a need to develop new cancer drugs. In this thesis new methods to screen for cancer drugs and to evaluate their mechanism of action are discussed. </p><p>In Paper I, it was found that by studying the gene expression of a cell line panel and combining the data with sensitivity data of a number of cytotoxic drugs, it was possible to cluster compounds according to mechanism of action as well as identifying genes associated with chemosensitivi

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16

Saidu, Dauda Kapu. "Studies on the mechanism of action and accumulation of structurally-distinct haeme-binding drugs." Thesis, University of Liverpool, 2006. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.430890.

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17

Mann, Catherine. "Mechanisms of action of antidepressant drugs: Presynaptic and postreceptor mechanisms." Thesis, University of Ottawa (Canada), 1992. http://hdl.handle.net/10393/10600.

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The etiology of clinical depression is unknown, but thought to be related to an impairment in brain transmission of monoamines. Depression is treated with antidepressant drugs which, regardless of classification, ultimately result in increased efficacy of aminergic transmission. Tricyclic antidepressants are known to inhibit the presynaptic uptake of amines. [3H]Imipramine, the prototype tricyclic antidepressant and a potential biological marker in depression, binds to both high- and a low-affinity sites in the brain. The high-affinity binding of [3H]imipramine to its binding site on the serot

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18

Lakey, Rachel Louisa. "The effects of anti-inflammatory drugs on cartilage breakdown and their mechanism of action chondrocytes." Thesis, Northumbria University, 2008. http://nrl.northumbria.ac.uk/3118/.

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The progressive loss of cartilage matrix is a major characteristic of arthritic disease, ultimately leading to a loss of joint function. A number of therapeutics are used in the treatment of arthritic disease, with non-steroidal anti-inflammatory drugs used to treat the pain and inflammation seen in osteoarthritis and rheumatoid arthritis, whilst disease modifying anti-rheumatic drugs are used to slow disease progression. However it is not fully understood if and how many of these drugs effect the disease processes in arthritis. The objective of this study is to look at a number of therapeutic

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19

Williams, Daffydd Griffin. "Mechanism of action of penetration enhancers." Thesis, Cardiff University, 1991. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.320625.

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20

Miller, Mark Russell. "The mechanism of action and therapeutic potential of S-nitrosothiols as novel nitric oxide donor drugs." Thesis, University of Edinburgh, 2003. http://hdl.handle.net/1842/24981.

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Recently, two novel S-nitrosothiols, N-(S-nitroso-<i>N</i>-acetylpenicillamine)-2-amino-2-deoxy-1,3,4,6,tetra-<i>O</i>-acetyl-β-D-glucopyranose (RIG200) and S-nitroso-<i>N</i>-valerylpenicillamine (SNVP), have been described to have selectivity for endothelium-denuded blood vessels. Therefore, they are particularly appealing in the treatment of conditions where the vascular endothelium is damaged. This thesis describes experiments which further elucidate the mechanism of action and therapeutic of these novel S-nitrosothiols, by comparison to conventional NO donors. The key findings were that

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21

Shao, Xingwu. "Reverse transcriptase assays for analysis of resistance to anti-HIV drugs and their mechanism of action /." Stockholm, 2003. http://diss.kib.ki.se/2003/91-7349-489-5.

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22

Atherton, Richard Roy Dalzell. "Mechanisms of action of nitazoxanide and related drugs against helminths." Thesis, London School of Hygiene and Tropical Medicine (University of London), 2004. http://researchonline.lshtm.ac.uk/682323/.

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The 5-nitrothiazole, nitazoxanide, is a novel compound with a broad spectrum of activity; effective against anaerobic/microaerophilic intestinal protozoa and bacteria. The mechanism of nitazoxanide's anthelmintic activity is unknown. This study examined the mode of action of nitazoxanide and analogues against nematodes, trematodes and cestodes. Caenorhabditis elegans, a free living nematode, was used as a model. Nitazoxanide was found to exert a transient spastic paralytic effect, particularly at the posterior end of the nematode, with 50% effect at 4.62µM. This effect is similar to that of le

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23

Sadeghi, Mahsa. "Mechanisms of action of novel analgesic drugs in pain pathways." Thesis, The University of Sydney, 2014. http://hdl.handle.net/2123/12329.

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Chronic pain is a significant health burden and despite all the attempts and progress, drugs used to treat chronic pain have relatively poor clinical efficacy. This thesis seeks to investigate the mechanisms of action of novel analgesic drugs that seem promising for pain management. Opioids acting through μ-opioid receptors (MOPr) are effective treatments for acute pain state but their side effect profiles and limited efficacy in chronic pain states reduce their therapeutic potential. On the other hand, inhibiting the uptake of noradrenaline (NA) or activating α2-adrenoceptors seems to be eff

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24

Martin, Duncan J. "Mechanism of action of the anticonvulsant drug gabapentin." Thesis, University of Aberdeen, 2002. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.395181.

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In this study, the whole-cell patch clamp technique and Fura-2 calcium (Ca<sup>2+</sup>) imaging techniques were employed to investigate the involvement of voltage activated calcium currents (VACCs) in the mechanism of action of the anticonvulsant drug gabapentin. Molecular biology studies were also carried out to assess which VACC subunits were required for drug sensitivity in particular cell cultures. Also investigated were the effects, if any, of gabapentin at GABA receptors and on cells of the F11 line. Voltage activated calcium currents were activated in cultured DRG neurones until a cons

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25

Mustafa, M. R. "Involvement of noradrenergic mechanisms in the antidepressant action of rolipram." Thesis, Cardiff University, 1987. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.378451.

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26

Schroeder, Frederick Albert. "A Role for Histone Modification in the Mechanism of Action of Antidepressant and Stimulant Drugs: a Dissertation." eScholarship@UMMS, 2007. https://escholarship.umassmed.edu/gsbs_diss/370.

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Depression and stimulant drug addiction each result in massive losses of health, productivity and human lives every year. Despite decades of research, current treatment regimes for depression are ineffective in approximately half of all patients. Therapy available to stimulant drug addicts is largely ineffective and moreover, dedicated treatments for drug dependence (including abuse of cocaine) are non-existent. Thus, there is a pressing need to further understanding of the molecular mechanisms underlying these disorders in order to develop novel, targeted therapeutic strategies. Chromatin rem

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27

Southerton, J. S. "Studies on the mechanisms of action of some smooth muscle relaxants." Thesis, University of Manchester, 1988. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.237287.

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28

Tchesnokov, Egor Petrovitch. "Mechanisms of action of drugs with dual or multiple antiviral activities." Thesis, McGill University, 2009. http://digitool.Library.McGill.CA:80/R/?func=dbin-jump-full&object_id=66639.

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Viral enzymes that catalyze replication of the viral genome remain the main subject of currently available antiviral therapies. This work focuses on three anti-viral agents that target viral DNA polymerases: foscarnet, acyclovir and entecavir. Though the broad spectrum of antiviral activities of foscarnet has been recognized for decades, only recently has it been shown that the anti-herpesvirus drug acyclovir and the anti-hepatitis B virus drug entecavir are also active against the human immunodeficiency virus (HIV) 1. The clinical benefits of the multiple antiviral activitie

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29

Febbo, Stacy M. "Effects of stimulant drugs on self-control choices in pigeons : determining behavioral mechanisms of drug action /." Electronic version (PDF), 2003. http://dl.uncw.edu/etd/2003/febbos/stacyfebbo.pdf.

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30

CASTELLI, SILVIA. "QUANTITATIVE PROTEOMIC APPROACHES TO STUDY DRUG MECHANISM OF ACTION." Doctoral thesis, Università degli Studi di Milano, 2023. https://hdl.handle.net/2434/950653.

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In recent years an increased number of covalent protein kinase inhibitors has been approved for cancer therapy and many more are undertaking clinical trials. Covalent binding is usually obtained by introducing in these drugs an electrophilic warhead able to bind specific nucleophilic sites in the protein target. Covalent inhibition of oncogenic protein kinases allows to obtain a stronger and prolonged therapeutic effect compared to reversible inhibition; however, the choice of the dose to be administered to patients and the evaluation of the selectivity among the kinase family are mandatory t

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31

Yang, Jianning. "Mechanism-Based Computational Models to Study Pharmacological Actions of Anticancer Drugs." The Ohio State University, 2009. http://rave.ohiolink.edu/etdc/view?acc_num=osu1249622434.

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32

Marcus, Monica M. "Mechanism of action of antipsychotic drugs: focus on the nucleus accumbens and the prefrontal cortex : an experimental study /." Stockholm, 2005. http://diss.kib.ki.se/2005/91-7140-284-5/.

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33

Hertel, Peter. "On the mechanisms of action of atypical antipsychotic drugs : an experimental study /." Stockholm, 1999. http://diss.kib.ki.se/1999/91-628-3634-X/.

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34

Haddjeri, Nasser. "Auto- and heteromodulation of the rat brain 5-HT system : involvement in the mechanism of action of antidepressant drugs." Thesis, National Library of Canada = Bibliothèque nationale du Canada, 1997. http://www.collectionscanada.ca/obj/s4/f2/dsk2/ftp02/NQ36978.pdf.

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35

Xie, Yan. "A PhenoTarget Approach for Identifying Bioactive Compounds that Interact with TB Proteins." Thesis, Griffith University, 2021. http://hdl.handle.net/10072/407560.

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Tuberculosis (TB) is the number one cause of human death from infectious disease in the world. Current treatments are challenged by the high levels of drug-resistant Mtb infection, which including rifampicin-resistant TB (RR-TB), multidrug-resistant TB (MDR-TB), and extensively drug resistant TB (XDR-TB). New drugs with mechanism of action (MOA) are required for more effective treatments. The literature review covered TB disease, the discovery of current treatments and clinic candidates, natural products in TB drugs, two drug discovery strategies phenotypic based drug discovery (PDD) and targe

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36

Slaughter, Alison Paige. "Mechanism of action of allosteric HIV-1 integrase inhibitors." The Ohio State University, 2015. http://rave.ohiolink.edu/etdc/view?acc_num=osu1428684473.

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37

Holtkamp, Dominik [Verfasser]. "Mechanisms of action of novel antiepileptic drugs in chronic epileptic hippocampus / Dominik Holtkamp." Bonn : Universitäts- und Landesbibliothek Bonn, 2019. http://d-nb.info/1188726315/34.

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38

Shanmugarajah, Dakshine. "Mechanism of action of BNP7787, a novel chemoprotective agent : a dissertation /." San Antonio : UTHSC, 2007. http://proquest.umi.com.libproxy.uthscsa.edu/pqdweb?did=1475179031&sid=1&Fmt=2&clientId=70986&RQT=309&VName=PQD.

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Dissertation (Ph.D.).--University of Texas Graduate School of Biomedical Sciences at San Antonio, 2007.<br>Vita. Briscoe Library received only one copy of this dissertation. It is shelved in the Archives for safekeeping. Includes bibliographical references.

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39

Rooke, Ronald. "Studies on mechanism of action of AZT and HIV-1 drug resistance." Thesis, McGill University, 1991. http://digitool.Library.McGill.CA:80/R/?func=dbin-jump-full&object_id=70202.

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The great adaptability of the Human Immunodeficiency Virus type 1 (HIV-1) and the exclusive use of zidovudine (3$ sp prime$azido-3$ sp prime$deoxythymidine or AZT) in the treatment of AIDS has motivated our search for HIV-1 strains resistant to this drug.<br>Our first attempt at obtaining such strains was made by using an in vitro approach in which a lymphoid cell line, chronically infected with HIV-1, was exposed to various drug concentrations. Although this system has never generated such mutants, we found that the progeny virus population, present in the culture fluids of these chronically

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40

Di, Pasqua Anthony J. "Carboplatin Exploring mechanism of action and improved drug delivery 1. Role of carbonate in the mechanism of action of carboplatin 2. Cytotoxicity of mesoporous silica nanomaterials /." Related electronic resource: Current Research at SU : database of SU dissertations, recent titles available full text, 2008. http://wwwlib.umi.com/cr/syr/main.

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41

Ghavami, Maryam. "Antimalarial Agents: New Mechanisms of Actions for Old and New Drugs." Diss., Virginia Tech, 2018. http://hdl.handle.net/10919/96192.

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Worldwide, malaria is one of the deadliest diseases. In 2016 it sickened 216 million people and caused 445,000 deaths. In order to control the spread of this deadly diseases to human, we can either target the mosquito vector (Anopheles gambiae) or the parasite (Plasmodium falciparum). Due to recent emergence of resistance to current insecticides and antimalarial drugs there is a pressing need to discover and develop new agents that engage new targets in these organisms. To circumvent the effect of resistance to pyrethroid insecticides on the efficacy of insecticide treated nets (ITNs), the us

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42

Errington, Adam C., and n/a. "Electrophysiological studies on the mechanism of action of the novel antiepileptic drug lacosamide." University of Otago. Department of Pharmacology & Toxicology, 2007. http://adt.otago.ac.nz./public/adt-NZDU20080613.162038.

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Lacosamide (LCM) is a new antiepileptic drug with a previously unknown mode of action. Using electrophysiological recording techniques in a range of in vitro preparations I have determined a mechanism of action of the new drug. In a 4-aminopyridine model of tonic-clonic seizures in rat visual cortex in vitro, LCM stereoselectively reduced maximal frequency and duration of tonic activity with EC[50�s] of 71 and 41 [mu]M respectively. LCM (100 [mu]M) significantly reduced excitability in whole cell patch clamped neurons producing non-selective reduction in the incidence of excitatory/inhibitor

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43

Urban, Jonathan Douglas Mailman Richard B. "Dopamine D2 receptor functional selectivity as a mechanism of atypical antipsychotic drug action." Chapel Hill, N.C. : University of North Carolina at Chapel Hill, 2006. http://dc.lib.unc.edu/u?/etd,688.

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Thesis (Ph. D.)--University of North Carolina at Chapel Hill, 2006.<br>Title from electronic title page (viewed Oct. 10, 2007). "... in partial fulfillment of the requirements for the degree of Doctor of Philosophy in the Curriculum of Toxicology." Discipline: Toxicology; Department/School: Medicine. On title page "2" appears as subscript.

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McHardy, Lianne M. "A study of the mechanism of action of novel inhibitors of tumour cell invasion." Thesis, University of British Columbia, 2007. http://hdl.handle.net/2429/252.

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Metastasis is the leading cause of death in cancer patients. Tumour invasion and migration are critical aspects of metastatic progression. A forward chemical genetics project was initiated in an effort to identify novel compounds that inhibit tumour invasion. After screening a natural extract library, two novel inhibitors were identified: motuporamine C (MotC) and strongylophorine-26 (STP-26). Structure-activity studies identified dihdyromotuporamine C (dhMotC) as a potent and easily synthesized analogue. In this work, the mechanism of activity of dhMotC and STP-26 was investigated. It was fou

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Nguyen, Albert Thu. "The molecular mechanism of action of bevirimat : a prototype HIV-1 maturation inhibitor /." Oklahoma City : [s.n.], 2009.

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Pariante, Carmine Maria. "The in vitro effects of antidepressants on the glucocorticoid receptor and the potential relevance for the mechanism of action of this class of drugs." Thesis, King's College London (University of London), 2003. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.406497.

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47

Petinou, Viviana. "Anti-cancer effects and mechanism of actions of aspirin-like drugs in the treatment of gliomas." Thesis, University of Central Lancashire, 2015. http://clok.uclan.ac.uk/12119/.

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In the past two decades only modest advancements in glioma treatment have been made, with patient prognosis and median survival time following diagnosis only increasing from 3 to 7 months. A substantial body of clinical and preclinical evidence has suggested a role for aspirin in the treatment of cancer with multiple mechanisms of action. Aspirin is one of the most widely used drugs, successfully taken as an analgesic, antipyretic, anti-inflammatory agent and for prevention of strokes and ischemic diseases. The effects on cell viability, proliferation, apoptosis and migration of aspirin and as

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48

Dierickx, Karen. "Contribution to the study of the efficacy and the mechanism of action of the alkylating peptide prolyl-m-sarcolysyl-p-fluorophenylalanine (PSF)." Doctoral thesis, Universite Libre de Bruxelles, 2008. http://hdl.handle.net/2013/ULB-DIPOT:oai:dipot.ulb.ac.be:2013/210390.

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The search for more effective treatment strategies in melanoma led to many new innovative approaches aiming at different molecular targets. Chemotherapy still remains the most effective treatment and many efforts are put in order to improve targeting and delivery of the chemotherapeutic agents. Among these, peptide conjugates of anticancer drugs were designed to increase stability, cell penetration, specificity and accumulation in cancer cells. We as well as others evaluated such a conjugate, termed PSF (L-prolyl-m-L-sarcolysyl-L-p-fluorophenylalanine-ethylester) in terms of its cytotoxicity i

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49

Mello, Jill Ann 1966. "Transcription and mismatch repair in the mechanism of action of the anticancer drug cisplatin." Thesis, Massachusetts Institute of Technology, 1997. http://hdl.handle.net/1721.1/42993.

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Thesis (Ph. D.)--Massachusetts Institute of Technology, Dept. of Chemistry, 1997.<br>Vita.<br>Includes bibliographical references (leaves 188-212).<br>cis-Diamminedichloroplatinum(II) (cis-DDP or cisplatin) is a powerful cytotoxin and anticancer therapeutic, used most effectively in the treatment of testicular and ovarian cancers. By contrast, the geometric isomer of cisplatin, trans- DDP, is comparatively non-toxic and fails to show significant antitumor activity. Cisplatin is believed to derive its cytotoxic effects from processes triggered by its reaction with DNA. The formation of cisplati

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Cooper, David L., Derek E. Murrell, David Roane, and Sam Harirforoosh. "Effects of Formulation Design on Niacin Therapeutics: Mechanism of Action, Metabolism, and Drug Delivery." Digital Commons @ East Tennessee State University, 2015. https://dc.etsu.edu/etsu-works/7166.

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Niacin is a highly effective, lipid regulating drug associated with a number of metabolically induced side effects such as prostaglandin (PG) mediated flushing and hepatic toxicity. In an attempt to reduce the development of these adverse effects, scientists have investigated differing methods of niacin delivery designed to control drug release and alter metabolism. However, despite successful formulation of various orally based capsule and tablet delivery systems, patient adherence to niacin therapy is still compromised by adverse events such as PG-induced flushing. While the primary advantag

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