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Journal articles on the topic 'Mechanism of action of drugs'

Author: Grafiati

Published: 5 June 2025

Last updated: 2 August 2025

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1

Edwards, David I. "Nitroimidazole drugs-action and resistance mechanisms I. Mechanism of action." Journal of Antimicrobial Chemotherapy 31, no. 1 (1993): 9–20. http://dx.doi.org/10.1093/jac/31.1.9.

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2

Luciani, S., S. Bova, and G. Cargnelli. "Mechanism of action of antihypertensive drugs." Pharmacological Research 22 (September 1990): 278. http://dx.doi.org/10.1016/s1043-6618(09)80309-5.

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3

Yaqub, Farhat. "Mechanism of action of anthracycline drugs." Lancet Oncology 14, no. 8 (2013): e296. http://dx.doi.org/10.1016/s1470-2045(13)70118-9.

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4

Nakashima, Shigeru. "Mechanism of Action of Anti-Fungal Drugs." Nippon Ishinkin Gakkai Zasshi 40, no. 3 (1999): 119–23. http://dx.doi.org/10.3314/jjmm.40.119.

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5

Vane, J. R., and R. M. Botting. "Mechanism of Action of Anti-Inflammatory Drugs." Scandinavian Journal of Rheumatology 25, sup102 (1996): 9–21. http://dx.doi.org/10.3109/03009749609097226.

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6

Pleuvry, Barbara J. "Mechanism of action of general anaesthetic drugs." Anaesthesia & Intensive Care Medicine 5, no. 10 (2004): 352–53. http://dx.doi.org/10.1383/anes.5.10.352.52309.

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7

Vane, John R., and Renia M. Botting. "Mechanism of action of aspirin-like drugs." Seminars in Arthritis and Rheumatism 26 (June 1997): 2–10. http://dx.doi.org/10.1016/s0049-0172(97)80046-7.

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8

Samanin, Rosario, and Silvio Garattini. "Neurochemical Mechanism of Action of Anorectic Drugs." Pharmacology & Toxicology 73, no. 2 (1993): 63–68. http://dx.doi.org/10.1111/j.1600-0773.1993.tb01537.x.

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9

Pleuvry, Barbara J. "Mechanism of action of general anaesthetic drugs." Anaesthesia & Intensive Care Medicine 9, no. 4 (2008): 152–53. http://dx.doi.org/10.1016/j.mpaic.2007.08.004.

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10

Best, Sabine L., and Peter J. Sadler. "Gold drugs: Mechanism of action and toxicity." Gold Bulletin 29, no. 3 (1996): 87–93. http://dx.doi.org/10.1007/bf03214741.

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11

Kausar, Shamaila, Fahad Said Khan, Muhammad Ishaq Mujeeb Ur Rehman, et al. "A review: Mechanism of action of antiviral drugs." International Journal of Immunopathology and Pharmacology 35 (January 2021): 205873842110026. http://dx.doi.org/10.1177/20587384211002621.

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Antiviral drugs are a class of medicines particularly used for the treatment of viral infections. Drugs that combat viral infections are called antiviral drugs. Viruses are among the major pathogenic agents that cause number of serious diseases in humans, animals and plants. Viruses cause many diseases in humans, from self resolving diseases to acute fatal diseases. Developing strategies for the antiviral drugs are focused on two different approaches: Targeting the viruses themselves or the host cell factors. Antiviral drugs that directly target the viruses include the inhibitors of virus atta

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12

Woroń, Jarosław. "Drugs containing extracts from Ruscus in chronic venal disease therapy – what's new we know about their effects?" Polish Journal of Surgery 94, no. 1 (2022): 75–78. http://dx.doi.org/10.5604/01.3001.0015.7954.

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Pharmacotherapy of venous insufficiency is based on the use of drugs which, through their mechanism of action, contribute to the complex pathomechanism of this disease. One of the drugs used in the treatment of CVD are extracts of Ruscus. Numerous studies have demonstrated a multidirectional mechanism of action involving the effect of the drug on the adrenergic and cholinergic systems and the intracellular calcium metabolism. All these mechanisms are responsible for the multidirectional mechanism of action of the drug.

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13

Sills, Graeme J., and Martin J. Brodie. "Update on the mechanisms of action of antiepileptic drugs." Epileptic Disorders 3, no. 4 (2001): 165–72. http://dx.doi.org/10.1684/j.1950-6945.2001.tb00392.x.

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ABSTRACT After a hiatus of almost 20 years, nine new antiepileptic drugs were licensed during the last decade of the 20th century. Expansion of the range of drug treatments for epilepsy complicates selection of the most suitable drug, or combination of drugs, for individual patients. Clinical experience suggests that mechanism of action may become an important criterion in this decision‐making process. At the cellular level, three major pharmacological actions are recognised: modulation of voltage‐dependent ion channels, enhancement of inhibitory neurotransmission, and attenuation of excitator

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14

Lyu, Weichen. "Antiviral Resistance in Influenza Virus: Mechanism of Action." Theoretical and Natural Science 4, no. 1 (2023): 634–38. http://dx.doi.org/10.54254/2753-8818/4/20220671.

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The "Spanish flu" pandemic caused by H1N1 virus in 1918 caused 50 million deaths. The best-known drugs for treating influenza viruses are antiviral drugs, including amantadine, rimantadine, zanamivir, and oseltamivir. Amantadine and rimantadine are excellent prophylactic drugs against influenza A. Whereas, Zanamivir and oseltamivir have comparable efficacy against influenza A and B viruses. This paper reviews antiviral drugs, approved for clinical use. This review evaluates neuraminidase inhibitors (NAIs), focusing on their mechanism of action and the emergence of resistance to them. The resul

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15

Kuzmanova, R., and I. Stefanova. "Basic Mechanisms of Action of the Antiepileptic Drugs." Acta Medica Bulgarica 44, no. 2 (2017): 52–58. http://dx.doi.org/10.1515/amb-2017-0020.

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AbstractAvailable antiepileptic drugs interact with a variety of different molecular targets. The mechanism of action of most anticonvulsants is most often complex with a number of affected regions. The combination of mechanisms of action of drugs in particular proportions can possibly determine the showcase of its antiepileptic activity. The common factor between the different supposed mechanisms for a number of drugs includes the possibility for modulating the excitatory and inhibitory neurotransmission through effects upon the voltage-gated ion channels, synaptic plasticity, heterogeneous r

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16

KAMIYA, KOICHIRO. "Simulation of the action mechanism of antiarrhythmic drugs." Japanese Journal of Electrocardiology 10, no. 2 (1990): 163–67. http://dx.doi.org/10.5105/jse.10.163.

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17

Yaksh, Tony L., David M. Dirig, and Annika B. Malmberg. "Mechanism of Action of Nonsteroidal Anti-inflammatory Drugs." Cancer Investigation 16, no. 7 (1998): 509–27. http://dx.doi.org/10.3109/07357909809011705.

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18

Bruera, Eduardo. "Mechanism of Action of Nonsteroidal Anti-inflammatory Drugs." Cancer Investigation 16, no. 7 (1998): 538–39. http://dx.doi.org/10.3109/07357909809011707.

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19

VAGHY, PAL L., KIYOSHI ITAGAKI, KUNIHISA MIWA, EDWARD McKENNA, and ARNOLD SCHWARTZ. "Mechanism of Action of Calcium Channel Modulator Drugs." Annals of the New York Academy of Sciences 522, no. 1 Calcium Antag (1988): 176–86. http://dx.doi.org/10.1111/j.1749-6632.1988.tb33353.x.

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20

Agambar, Lindsay, and Rod Flower. "Anti-inflammatory Drugs: History and mechanism of action." Physiotherapy 76, no. 4 (1990): 198–202. http://dx.doi.org/10.1016/s0031-9406(10)62174-8.

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21

Scholz, H. "Classification and mechanism of action of antiarrhythmic drugs." Fundamental & Clinical Pharmacology 8, no. 5 (1994): 385–90. http://dx.doi.org/10.1111/j.1472-8206.1994.tb00817.x.

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22

Livingston, Alexander. "Mechanism of Action of Nonsteroidal Anti-Inflammatory Drugs." Veterinary Clinics of North America: Small Animal Practice 30, no. 4 (2000): 773–81. http://dx.doi.org/10.1016/s0195-5616(08)70006-8.

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23

Vane, John R., and Regina M. Botting. "Mechanism of Action of Nonsteroidal Anti-inflammatory Drugs." American Journal of Medicine 104, no. 3 (1998): 2S—8S. http://dx.doi.org/10.1016/s0002-9343(97)00203-9.

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24

Luethi, Dino, and Matthias E. Liechti. "Designer drugs: mechanism of action and adverse effects." Archives of Toxicology 94, no. 4 (2020): 1085–133. http://dx.doi.org/10.1007/s00204-020-02693-7.

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25

Casucci, Gerardo, Veronica Villani, and Fabio Frediani. "Central mechanism of action of antimigraine prophylactic drugs." Neurological Sciences 29, S1 (2008): 123–26. http://dx.doi.org/10.1007/s10072-008-0902-9.

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26

Frediani, Fabio, Veronica Villani, and Gerardo Casucci. "Peripheral mechanism of action of antimigraine prophylactic drugs." Neurological Sciences 29, S1 (2008): 127–30. http://dx.doi.org/10.1007/s10072-008-0903-8.

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27

Palumbo, Manlio, Barbara Gatto, Giuseppe Zagotto, and Giorgio Palù. "On the mechanism of action of quinolone drugs." Trends in Microbiology 1, no. 6 (1993): 232–35. http://dx.doi.org/10.1016/0966-842x(93)90138-h.

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28

Meltzer, H. Y. "The Mechanism of Action of Novel Antipsychotic Drugs." Schizophrenia Bulletin 17, no. 2 (1991): 263–87. http://dx.doi.org/10.1093/schbul/17.2.263.

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29

Reedijk, J. "The mechanism of action of platinum antitumor drugs." Pure and Applied Chemistry 59, no. 2 (1987): 181–92. http://dx.doi.org/10.1351/pac198759020181.

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30

Vane, J. R., and R. M. Botting. "Anti-inflammatory drugs and their mechanism of action." Inflammation Research 47 (December 3, 1998): 78–87. http://dx.doi.org/10.1007/s000110050284.

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31

Muralinath, E., Devi Pooja, Chbukdhara Prasanta, et al. "Understanding the Mechanism of Action of Antitussive Drugs." Journal of Advances in Experimental Therapeutics and Neurotherapeutics 2, no. 1 (2024): 17–20. https://doi.org/10.5281/zenodo.10795828.

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<em>Coughing is a natural reflex that assists in clearing the airways of irritants and mucus. Opioid have been used as an effective antitussive compounds namely codeine and hydro condone are helpful in stopping coughing in a wide manner. By binding with mu Opioid receptors, opioid ms stop the release of neurotransmitters particularly participated I'm the cough reflex and decrease the urge to cough. Dextro methorphin ( DXM) is a non_ Opioid derivative that participates in the over the counter cough medications. If performs centrally by blocking N_ methyl_D_ asparate (NMDA) receptors and stoppin

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32

Thomas, Charlotte M., and David J. Timson. "The Mechanism of Action of Praziquantel: Can New Drugs Exploit Similar Mechanisms?" Current Medicinal Chemistry 27, no. 5 (2020): 676–96. http://dx.doi.org/10.2174/0929867325666180926145537.

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Praziquantel (PZQ) is the drug of choice for treating infection with worms from the genus Schistosoma. The drug is effective, cheap and has few side effects. However, despite its use in millions of patients for over 40 years its molecular mechanism of action remains elusive. Early studies demonstrated that PZQ disrupts calcium ion homeostasis in the worm and the current consensus is that it antagonises voltage-gated calcium channels. It is hypothesised that disruption of these channels results in uncontrolled calcium ion influx leading to uncontrolled muscle contraction and paralysis. However,

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33

Ayyad, Rezk R., Ahmed M. Nejm, Yasser Abdel Allem Hassan, and Ahmed R. Ayyad. "Mechanism of Action of Many Drugs Depend on Enzyme Inhibition." Current Research in Medical Sciences 2, no. 4 (2023): 1–9. http://dx.doi.org/10.56397/crms.2023.12.01.

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Enzyme inhibition is an important process in the mode of action of many drugs used in the treatment of various diseases. Antibiotics, anti-hypertensive agents, anti-hyperlipidaemic, anti-glaucoma, and anti-malarial drugs act on specific enzymes, leading to bacteriostatic or bactericidal effects, lower blood pressure, reduce cholesterol levels, and cause smooth muscle relaxation of blood vessels. Understanding the mode of action of these drugs and how they affect enzymes is crucial for the development of new drugs and the optimization of existing therapies. This article highlights some various

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34

Wang, Feng, Robert Langley, Gulcin Gulten, et al. "Mechanism of thioamide drug action against tuberculosis and leprosy." Journal of Experimental Medicine 204, no. 1 (2007): 73–78. http://dx.doi.org/10.1084/jem.20062100.

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Thioamide drugs, ethionamide (ETH) and prothionamide (PTH), are clinically effective in the treatment of Mycobacterium tuberculosis, M. leprae, and M. avium complex infections. Although generally considered second-line drugs for tuberculosis, their use has increased considerably as the number of multidrug resistant and extensively drug resistant tuberculosis cases continues to rise. Despite the widespread use of thioamide drugs to treat tuberculosis and leprosy, their precise mechanisms of action remain unknown. Using a cell-based activation method, we now have definitive evidence that both th

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35

Palko, N., V. Potemkin, and M. Grishina. "Decision Tree for Mechanism of Antitumor Drugs Action Prediction." Bulletin of the South Ural State University series "Chemistry" 11, no. 1 (2019): 18–24. http://dx.doi.org/10.14529/chem190102.

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36

Zeng, Daina, Dmitri Debabov, Theresa L. Hartsell, et al. "Approved Glycopeptide Antibacterial Drugs: Mechanism of Action and Resistance." Cold Spring Harbor Perspectives in Medicine 6, no. 12 (2016): a026989. http://dx.doi.org/10.1101/cshperspect.a026989.

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37

Lieberman, Jeffrey A. "Understanding the Mechanism of Action of Atypical Antipsychotic Drugs." British Journal of Psychiatry 163, S22 (1993): 7–18. http://dx.doi.org/10.1192/s0007125000292544.

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The thrust of development of new antipsychotic drugs has been to identify new compounds that have enhanced antipsychotic efficacy and have lesser side-effects than standard neuroleptic compounds. Drug development strategies no longer concentrate on D2 receptor antagonism but aim to produce novel compounds. The following have been pursued: (a) selective dopamine receptor antagonists; (b) serotonin receptor agonists and antagonists (5-HT1a,e, 5-HT2, 5-HT3) or mixed 5-HT2 - D2 receptor antagonist; (c) selective dopamine agonists or partial agonists; and (d) sigma-site and excitatory amino-acid an

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38

Sulser, F., J. Watts, and Bernard B. Brodie. "ON THE MECHANISM OF ANTIDEPRESSANT ACTION OF IMIPRAMINELIKE DRUGS." Annals of the New York Academy of Sciences 96, no. 1 (2006): 279–88. http://dx.doi.org/10.1111/j.1749-6632.1962.tb50122.x.

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39

CROOKE, STANLEY T. "Evaluating the Mechanism of Action of Antiproliferative Antisense Drugs." Antisense and Nucleic Acid Drug Development 10, no. 2 (2000): 123–26. http://dx.doi.org/10.1089/oli.1.2000.10.123.

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40

Amsterdam, E. A. "Mechanism of Action of Antianginal Drugs: What Is It?" Cardiology 74, no. 6 (1987): 425–26. http://dx.doi.org/10.1159/000174247.

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41

Forrest, Michael, and Peter M. Brooks. "Mechanism of action of non-steroidal anti-rheumatic drugs." Baillière's Clinical Rheumatology 2, no. 2 (1988): 275–94. http://dx.doi.org/10.1016/s0950-3579(88)80015-3.

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42

Meltzer, H. Y. "Mechanism of action of clozapine — like atypical antipsychotic drugs." European Neuropsychopharmacology 1, no. 3 (1991): 351. http://dx.doi.org/10.1016/0924-977x(91)90561-8.

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43

Reglinski, J., and W. E. Smith. "Mechanism of action of the gold drugs in arthritis." Journal of Inorganic Biochemistry 51, no. 1-2 (1993): 418. http://dx.doi.org/10.1016/0162-0134(93)85447-g.

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44

Gregori-Puigjane, E., V. Setola, J. Hert, et al. "Identifying mechanism-of-action targets for drugs and probes." Proceedings of the National Academy of Sciences 109, no. 28 (2012): 11178–83. http://dx.doi.org/10.1073/pnas.1204524109.

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45

Jackson, Richard T. "Mechanism of Action of Some Commonly Used Nasal Drugs." Otolaryngology–Head and Neck Surgery 104, no. 4 (1991): 433–40. http://dx.doi.org/10.1177/019459989110400403.

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46

Meldrum, Brian S. "Update on the Mechanism of Action of Antiepileptic Drugs." Epilepsia 37, s6 (1996): S4—S11. http://dx.doi.org/10.1111/j.1528-1157.1996.tb06038.x.

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47

Contreras-García, Itzel Jatziri, Noemí Cárdenas-Rodríguez, Antonio Romo-Mancillas, et al. "Levetiracetam Mechanisms of Action: From Molecules to Systems." Pharmaceuticals 15, no. 4 (2022): 475. http://dx.doi.org/10.3390/ph15040475.

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Epilepsy is a chronic disease that affects millions of people worldwide. Antiepileptic drugs (AEDs) are used to control seizures. Even though parts of their mechanisms of action are known, there are still components that need to be studied. Therefore, the search for novel drugs, new molecular targets, and a better understanding of the mechanisms of action of existing drugs is still crucial. Levetiracetam (LEV) is an AED that has been shown to be effective in seizure control and is well-tolerable, with a novel mechanism of action through an interaction with the synaptic vesicle protein 2A (SV2A

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48

Coulter, Douglas A. "Antiepileptic Drug Cellular Mechanisms of Action: Where Does Lamotrigine Fit In?" Journal of Child Neurology 12, no. 1_suppl (1997): S2—S9. http://dx.doi.org/10.1177/0883073897012001031.

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Current frontline antiepileptic drugs tend to fall into several cellular mechanistic categories, and these categories often correlate with the clinical spectrum of action of the various antiepileptic drugs. Many antiepileptic drugs effective in control of partial and generalized tonic-clonic seizures are use- and voltage-dependent blockers of sodium channels. This mechanism selectively dampens pathologic activation of sodium channels, without interacting with normal sodium channel function. Examples include phenytoin, carbamazepine, valproic acid, and lamotrigine. Many antiepileptic drugs effe

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49

Asadi‐Pooya, Ali A., Maromi Nei, Ashwini D. Sharan, et al. "Antiepileptic drugs and relapse after epilepsy surgery." Epileptic Disorders 10, no. 3 (2008): 193–98. http://dx.doi.org/10.1684/epd.2008.0198.

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ABSTRACT Purpose To evaluate whether the postoperative, antiepileptic drug (AED) regimen influences seizure recurrence after anterior temporal lobectomy when considering the putative mechanism of action and possible neuroprotective effects. Methods This was a retrospective study. Patients who had an anterior temporal lobectomy for refractory epilepsy, whose preoperative MRI indicated mesial temporal sclerosis, were included. Postoperative AED regimens were compared with regard to seizure‐outcome, considering the putative mechanism of action (sodium channel blockers, non‐sodium channel blockers

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50

Goodin, Susan, Michael P. Kane, and Eric H. Rubin. "Epothilones: Mechanism of Action and Biologic Activity." Journal of Clinical Oncology 22, no. 10 (2004): 2015–25. http://dx.doi.org/10.1200/jco.2004.12.001.

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Drugs that target microtubules are among the most commonly prescribed anticancer therapies. Although the mechanisms by which perturbation of microtubule function leads to selective death of cancer cells remain unclear, several new microtubule-targeting compounds are undergoing clinical testing. In part, these efforts focus on overcoming some of the problems associated with taxane-based therapies, including formulation and administration difficulties and susceptibility to resistance conferred by P-glycoprotein. Epothilones have emerged from these efforts as a promising new class of anticancer d

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