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Relevant bibliographies by topics / Mechanism of action of melatonin

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Academic literature on the topic 'Mechanism of action of melatonin'

Author: Grafiati

Published: 5 June 2025

Last updated: 2 August 2025

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Journal articles on the topic "Mechanism of action of melatonin"

1

Maharaj, Deepa S., Beverley D. Glass, and Santy Daya. "Melatonin: New Places in Therapy." Bioscience Reports 27, no. 6 (2007): 299–320. http://dx.doi.org/10.1007/s10540-007-9052-1.

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The fact that the full extent of the function of the pineal gland has not yet been elucidated, has stimulated melatonin research worldwide. This review introduces melatonin's mechanism of action, direct and indirect antioxidant actions as well as the antioxidant properties of its metabolites, 6-hydroxymelatonin (6-OHM) and N-acetyl-N-formyl-5-methoxykynurenamine (AFMK). At present the mechanism of action is proposed to be receptor-, protein- and nonprotein-mediated. From its popular role in the treatment of jetlag, melatonin is now implicated in the reduction of oxidative stess, both as a free

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Fernandez-Gil, Beatriz I., Andrea Otamendi-Lopez, Alexandra Bechtle, et al. "Melatonin Treatment Triggers Metabolic and Intracellular pH Imbalance in Glioblastoma." Cells 11, no. 21 (2022): 3467. http://dx.doi.org/10.3390/cells11213467.

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Metabolic rewiring in glioblastoma (GBM) is linked to intra- and extracellular pH regulation. In this study, we sought to characterize the role of melatonin on intracellular pH modulation and metabolic consequences to identify the mechanisms of action underlying melatonin oncostatic effects on GBM tumor initiating cells. GBM tumor initiating cells were treated at different times with melatonin (1.5 and 3.0 mM). We analyzed melatonin’s functional effects on GBM proliferation, cell cycle, viability, stemness, and chemo-radiosensitivity. We then assessed the effects of melatonin on GBM metabolism

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VANECEK, JIRI. "Cellular Mechanisms of Melatonin Action." Physiological Reviews 78, no. 3 (1998): 687–721. http://dx.doi.org/10.1152/physrev.1998.78.3.687.

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Vanecek, Jiri. Cellular Mechanisms of Melatonin Action. Physiol. Rev. 78: 687–721, 1998. — The pineal hormone melatonin is involved in photic regulations of various kinds, including adaptation to light intensity, daily changes of light and darkness, and seasonal changes of photoperiod lengths. The melatonin effects are mediated by the specific high-affinity receptors localized on plasma membrane and coupled to GTP-binding protein. Two different G proteins coupled to the melatonin receptors have been described, one sensitive to pertussis toxin and the other sensitive to cholera toxin. On the ba

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Lee, Jung Goo, Young Sup Woo, Sung Woo Park, Dae-Hyun Seog, Mi Kyoung Seo, and Won-Myong Bahk. "The Neuroprotective Effects of Melatonin: Possible Role in the Pathophysiology of Neuropsychiatric Disease." Brain Sciences 9, no. 10 (2019): 285. http://dx.doi.org/10.3390/brainsci9100285.

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Melatonin is a hormone that is secreted by the pineal gland. To date, melatonin is known to regulate the sleep cycle by controlling the circadian rhythm. However, recent advances in neuroscience and molecular biology have led to the discovery of new actions and effects of melatonin. In recent studies, melatonin was shown to have antioxidant activity and, possibly, to affect the development of Alzheimer’s disease (AD). In addition, melatonin has neuroprotective effects and affects neuroplasticity, thus indicating potential antidepressant properties. In the present review, the new functions of m

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Kumari, Aradhna, Santosh Kumar Singh, Bhupendra Mathpal, et al. "The Biosynthesis, Mechanism of Action, and Physiological Functions of Melatonin in Horticultural Plants: A Review." Horticulturae 9, no. 8 (2023): 913. http://dx.doi.org/10.3390/horticulturae9080913.

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Melatonin, a hormone known for its role in regulating sleep–wake cycles in mammals, has been found to have diverse functions in horticultural plants. In recent years, research has revealed the involvement of melatonin in variousphysiological processes in plants, likeregulation of growth and development, stress tolerance, and antioxidant defense. Melatonin can augment seed germination, roots, shoot growth, and biomass accumulation in horticultural crops. It also performs a vital role in regulating vegetative and reproductive growth stages, floral transition, and leaf senescence. Melatonin impro

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Erland, Lauren A. E., Christopher R. Dumigan, Jillian A. Forsyth, et al. "Mammalian Melatonin Agonist Pharmaceuticals Stimulate Rhomboid Proteins in Plants." Biomolecules 12, no. 7 (2022): 882. http://dx.doi.org/10.3390/biom12070882.

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Melatonin is a human neurotransmitter and plant signalling metabolite that perceives and directs plant metabolism. The mechanisms of melatonin action in plants remain undefined. We hypothesized that roots have a melatonin-specific receptor and/or transporter that can respond to melatonin-mediating pharmaceuticals. To test this hypothesis Arabidopsis seedlings were grown with melatonin pharmaceutical receptor agonists: ramelteon and tasimelteon, and/or antagonists: luzindole and 4-P-PDOT. Ramelteon was found both to mimic and competitively inhibit melatonin metabolism in plants. Due to the high

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Liu, Lifeng, Ying Xu, Russel J. Reiter, et al. "Inhibition of ERK1/2 Signaling Pathway is Involved in Melatonin's Antiproliferative Effect on Human MG-63 Osteosarcoma Cells." Cellular Physiology and Biochemistry 39, no. 6 (2016): 2297–307. http://dx.doi.org/10.1159/000447922.

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Background: In a previous study, we found that melatonin inhibits MG-63 osteosarcoma cell proliferation; however, the underlying mechanisms remain elusive. Mitogen-activated protein kinase (MAPK) and Akt signaling pathways play key roles in the anticancer effects of melatonin. Aims: The present study investigated whether MAPK and Akt signaling pathways are involved in melatonin's antiproliferative actions on the human MG-63 osteosarcoma cells. Methods/Results: Western blot analysis confirmed that melatonin significantly inhibited phosphorylation of ERK1/2 but not p38, JNK, or Akt. The expressi

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Rijal, Santosh, Dong Hyu Cho, Seon-Ah Park, Seon Hui Jang, István M. Ábrahám, and Seong Kyu Han. "Melatonin Suppresses the Kainate Receptor-Mediated Excitation on Gonadotropin-Releasing Hormone Neurons in Female and Male Prepubertal Mice." International Journal of Molecular Sciences 21, no. 17 (2020): 5991. http://dx.doi.org/10.3390/ijms21175991.

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Melatonin, a pineal gland secretion, is an amphiphilic neurohormone involved in the biological and physiologic regulation of bodily functions. Numerous studies have shown the effects of melatonin on the release of gonadotropins and their actions at one or several levels of the hypothalamic–pituitary–gonadal axis. However, direct melatonin action on gonadotropin-releasing hormone (GnRH) neurons and its mechanism of action remain unclear. Here, plasma melatonin levels were measured and the effect of melatonin on GnRH neurons was assessed using brain slice patch clamp techniques. The plasma melat

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Nakano, Masaki, Mika Ikegame, Junko Igarashi-Migitaka, Yusuke Maruyama, Nobuo Suzuki, and Atsuhiko Hattori. "Suppressive effect of melatonin on osteoclast function via osteocyte calcitonin." Journal of Endocrinology 242, no. 2 (2019): 13–23. http://dx.doi.org/10.1530/joe-18-0707.

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Many studies have investigated the actions of melatonin on osteoblasts and osteoclasts. However, the underlying mechanisms, especially regarding osteocyte function, remain largely unknown. Therefore, this study aimed to clarify the underlying mechanisms of melatonin action on bone tissue via osteocyte function. Chick calvariae were employed as a model. In ovo injection of melatonin (5, 50 and 500 µg) dose-dependently decreased the mRNA expression levels of cathepsin K and matrix metalloproteinase 9 (MMP9) in chick calvariae without affecting the expression levels of receptor activator of NF-κB

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Vanecek, Jiri. "Cellular Mechanism of Melatonin Action in Neonatal Rat Pituitary." Neuroendocrinology 61, no. 1 (1995): 27–30. http://dx.doi.org/10.1159/000126823.

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Dissertations / Theses on the topic "Mechanism of action of melatonin"

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Avila, Goñi Leonor. "Human melatonin receptors molecular mechanisms of action and their implication in cell proliferation /." [S.l.] : [s.n.], 2003. http://deposit.ddb.de/cgi-bin/dokserv?idn=968548989.

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Giddins, R. E. "Behavioural and biochemical correlates of melatonin action in the rodent brain." Thesis, University of Bradford, 1985. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.371472.

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Lemus-Wilson, Athena Marie. "Melatonin and breast cancer: Investigation of a potential involvement of prolactin in the mechanism by which melatonin inhibits cell growth." Diss., The University of Arizona, 1993. http://hdl.handle.net/10150/186578.

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The pineal hormone melatonin (MLT) inhibits the promotion of human breast cancer cell growth in vitro by prolactin (PRL). When MCF-7 estrogen receptor (ER) positive human breast cancer cells were grown in a monolayer culture system containing 5% charcoal-stripped fetal bovine serum (CSS) in the presence of PRL and/or MLT for up to 6-days, MLT at each of the time-points tested significantly reduced the mitogenic response to PRL. In fact, in some instances the addition of MLT further reduced growth below the levels of untreated controls. Doses of MLT within the normal nighttime physiological ran

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Thapan, Kavita. "The spectral sensitivity of light-induced melatonin suppression in humans." Thesis, University of Surrey, 2001. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.365184.

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Tatarski, Miloš. "Molecular mechanism of dBigH1 action." Doctoral thesis, Universitat de Barcelona, 2018. http://hdl.handle.net/10803/663021.

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INTRODUCTION: For decades it was known that many species contain embryo specific linker histone H1 variants that replace the somatic H1 during early embryogenesis. This is especially important because the early embryo shows typically zero to very little activity of transcription, and the first cleavages of the embryo depend exclusively on maternally deposited factors that are important for transcription and chromatin assembly. The first species shown to contain an embryo specific histone H1 was the sea urchin. Other species like the mouse, Xenopus or the zebrafish followed. Even in humans t

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Attarzadeh, Yazdi Ghassem. "Molecular mechanism of glucocorticoid action." Thesis, University of Edinburgh, 2006. http://hdl.handle.net/1842/26161.

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The aim of this thesis project was to investigate the mechanisms by which glucocorticoid hormones regulate the activity of BK channels in human embryonic kidney 293 (HEK293) cells as the model system for glucocorticoids-action. It was shown that glucocorticoids act <i>via </i>endogenously expressed type II receptors in a concentration- and time-dependent manner in these cells. Dexamethasone (100 nM) had no significant effect on <i>Dexras1 </i>mRNA but significantly increased serum- and glucocorticoid-induced protein kinase 1 (SGK-1) mRNA. Biochemical analysis showed that SGK-1 protein is incre

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Conti, Lucio. "The molecular mechanism of TFL1 action." Thesis, University of East Anglia, 2005. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.423575.

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During Arabidopsis development the shoot apical meristem (SAM) generates lateral primordia which display stage-specific traits. In long days, wild-type Arabidopsis generates leaves in an initial vegetative phase (V). Upon integration of environmental and endogenous signals, the SAM enters the reproductive phase. First it makes an 11 phase, which consists of 2-3 leaves (cauline) subtending secondary shoots (coflorescences). Next it enters the 12 phase and produces flowers on its flanks. The TFL 1 gene is a key component of the phase change machinery as mutations in TFL 1 affect the timing of ph

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Beastall, J. C. "The mechanism of action of azone." Thesis, University of Nottingham, 1987. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.380112.

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Williams, Daffydd Griffin. "Mechanism of action of penetration enhancers." Thesis, Cardiff University, 1991. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.320625.

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Taylor, Catherine. "A mechanism of action of strigolactone." Thesis, University of Cambridge, 2015. https://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.709140.

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Books on the topic "Mechanism of action of melatonin"

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Hickman, Alison Burgess. Melatonin biosynthesis: The structure of serotonin N-acetyltransferace at 2.5 Å resolution suggests a catalytic mechanism. National Institute of Environmental Health Sciences], 1999.

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1925-, Kuby Stephen Allen, ed. Mechanism of enzyme action. CRC Press, 1991.

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Govil, J. N., Amani S. Awaad, and Geetanjali Kaushik. Mechanism and action of phytoconstituents. Studium Press, 2011.

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Golan, Adam E. Cellulase: Types and action, mechanism, and uses. Nova Science Publishers, 2011.

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1945-, Moudgil V. K., ed. Molecular mechanism of steroid hormone action: Recent advances. Walter de Gruyter, 1985.

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Woo, Junghoon. Interrogating Drug Mechanism of Action Using Network Dysregulation Analysis. [publisher not identified], 2015.

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Deans, Bryan. Studies on the mechanism of action on antitumour imidazotetrazinones. Aston University. Department ofPharmaceutical and Biological Sciences, 1994.

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Hickman, John Angus. Studies of the mechanism of action of antitumour compounds. Aston University. Department of Pharmaceutical Sciences, 1989.

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1946-, Barnes Peter J., ed. The Mechanism of action of Xanthines in respiratory disease. Royal Society of Medicine Services, 1988.

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Lewis, John. Mechanism of action of overbased additives in hydrocarbon media. University of East Anglia, 1991.

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Book chapters on the topic "Mechanism of action of melatonin"

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Niles, Lennard P. "Molecular Mechanisms of Melatonin Action: Targets in Sleep Regulation." In Neuroendocrine Correlates of Sleep/Wakefulness. Springer US, 2006. http://dx.doi.org/10.1007/0-387-23692-9_6.

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Guerrero, J. M., M. Rafi-El-Idrissi, S. Garcia-MauriNo, M. Gil-Haba, D. Pozo, and J. R. Calvo. "Mechanisms of Action of Melatonin on the Human Immune System. Membrane versus Nuclear Receptors." In Frontiers of Hormone Research. KARGER, 1997. http://dx.doi.org/10.1159/000060985.

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Cardinali, Daniel P., Rodolfo A. Cutrera, Luis I. Brusco, and Ana I. Esquifino. "The Role of Melatonin in the Neuroendocrine System: Multiplicity of Sites and Mechanisms of Action." In The Pineal Gland and Cancer. Springer Berlin Heidelberg, 2001. http://dx.doi.org/10.1007/978-3-642-59512-7_3.

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Blask, David E., Samuel Cos, Steven M. Hill, Danny M. Burns, Athena Lemus-Wilson, and David S. Grosso. "Melatonin Action on Oncogenesis." In Role of Melatonin and Pineal Peptides in Neuroimmunomodulation. Springer US, 1991. http://dx.doi.org/10.1007/978-1-4615-3756-4_26.

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Fraschini, Franco, Francesco Scaglione, Daniele Esposti, Germana Demartini, Valeria Lucini, and Bojidar Stankov. "Opioid Involvement in Melatonin Action." In Role of Melatonin and Pineal Peptides in Neuroimmunomodulation. Springer US, 1991. http://dx.doi.org/10.1007/978-1-4615-3756-4_17.

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Safe, Stephen H., Thomas Gasiewicz, and James P. Whitlock. "Mechanism of Action." In Environmental Toxin Series. Springer Berlin Heidelberg, 1990. http://dx.doi.org/10.1007/978-3-642-70556-4_3.

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Ermis, Hande, and Deniz Aksu Arica. "Mechanism of Action." In Jak-Inhibitors in Dermatology. Springer Nature Switzerland, 2025. https://doi.org/10.1007/978-3-031-84274-0_4.

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Maestroni, Georges J. M., and Ario Conti. "Action of Melatonin on Immune System." In Role of Melatonin and Pineal Peptides in Neuroimmunomodulation. Springer US, 1991. http://dx.doi.org/10.1007/978-1-4615-3756-4_22.

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Korf, H. W., C. Schomerus, and J. H. Stehle. "Action, Targets, and Receptors of Melatonin." In Advances in Anatomy, Embryology and Cell Biology. Springer Berlin Heidelberg, 1998. http://dx.doi.org/10.1007/978-3-642-58932-4_6.

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Mostafa, Manal, Amal-Asran, Hassan Almoammar, and Kamel A. Abd-Elsalam. "Nanoantimicrobials Mechanism of Action." In Nanotechnology in the Life Sciences. Springer International Publishing, 2018. http://dx.doi.org/10.1007/978-3-319-91161-8_11.

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Conference papers on the topic "Mechanism of action of melatonin"

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Wu, Wanghui, Tao Lu, Jiaming Wang, Pan Tang, and Fangqun Gao. "Temporal Action Detection with Frequency Attention Mechanism." In 2024 7th International Conference on Mechatronics, Robotics and Automation (ICMRA). IEEE, 2024. https://doi.org/10.1109/icmra62519.2024.10809079.

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Williams, Terry M. "The Mechanism of Action of Isothiazolone Biocides." In CORROSION 2006. NACE International, 2006. https://doi.org/10.5006/c2006-06090.

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Abstract Isothiazolone biocides have proven efficacy and performance for microbial control in a variety of industrial water treatment applications. Understanding the mechanism of action of industrial biocides is important in optimizing their use and combating resistance if encountered. Isothiazolones utilizes a two-step mechanism involving rapid inhibition (minutes) of growth and metabolism, followed by irreversible cell damage resulting in loss of viability (hours). Cells are inhibited by disruption of the metabolic pathways involving dehydrogenase enzymes. Critical physiological functions ar

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Kreshchenko, N. D., and D. E. Mitkovskii. "MELATONIN STIMULATES PHOTORECEPTOR DIFFERENTIATION IN REGENERATION OF PLANARIAN SCHMIDTEA MEDITERRANEA." In THEORY AND PRACTICE OF PARASITIC DISEASE CONTROL. All-Russian Scientific Research Institute for Fundamental and Applied Parasitology of Animals and Plant – a branch of the Federal State Budget Scientific Institution “Federal Scientific Centre VIEV”, 2023. http://dx.doi.org/10.31016/978-5-6048555-6-0.2023.24.229-234.

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The planarian Schmidtea mediterranea (Turbellaria, Platyhelminthes) has a pair of eyes on the anterior part of the body consisting of pigment cells and photoreceptor neurons capable of regeneration. The research represents a study of the effects of melatonin on photoreceptor differentiation after decapitation of the planarian. During the experiment, the worms were decapitated, and the eye regeneration was observed at days 3 and 4 of the regeneration. Different stages of the photoreceptor regeneration were observed such as both eyes in the regenerating

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Đorđević, Neda, Vladana Petković, Otilija Keta, et al. "CYTOTOXIC EFFECTS OF MELATONIN-TREATED MUSCAT HAMBURG WINE ON HT-29 AND PANC-1 CELLS." In 3rd International Symposium on Biotechnology. University of Kragujevac, Faculty of Agronomy in Čačak, 2025. https://doi.org/10.46793/sbt30.56ndj.

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The wine industry advances winemaking techniques to improve wine quality, sensory attributes, and potential health benefits. This study investigates the in vitro cytotoxic effects of Muscat Hamburg red wine enriched with melatonin during vinification. The biological activity was assessed using colorectal cancer (HT-29) and pancreatic cancer (PANC-1) cell lines. Results indicate that the melatonin-enriched wine exhibits cytotoxicity against both cell lines, with a stronger effect on PANC-1 compared to control wine, while both wines had similar effects on HT-29 cells. Further research is needed

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Kaminskaya, Olga V., Edward B. Arushanyan, Karine S. Elbekyan, and Edward V. Beyer. "Morphological evidence of the anti-stress action of melatonin." In II Международная конференция, посвящеенная 100- летию И.А. Држевецкой. СКФУ, 2022. http://dx.doi.org/10.38006/9612-62-6.2022.166.169.

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Cai, Yiheng, Xinran Kong, and Xueyan Wang. "Temporal Action Detection with Long Action Seam Mechanism." In the 2nd International Conference. ACM Press, 2018. http://dx.doi.org/10.1145/3278198.3278224.

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Nelson, Jack, Nick Klein, Andrew Swift, Pete Matthews, and Emily Drapal. "Doptelet Mechanism of Action Animation." In SIGGRAPH '24: ACM SIGGRAPH 2024 Electronic Theater. ACM, 2024. http://dx.doi.org/10.1145/3641230.3653313.

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Wang, Yunlong, Xiang Liu, Chuang Yu, and Zhaowei Guo. "Mechanism Action Detection Based on YOLO." In 2023 International Conference on Image Processing, Computer Vision and Machine Learning (ICICML). IEEE, 2023. http://dx.doi.org/10.1109/icicml60161.2023.10424896.

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Xiaoping, Liu, and Qi Liangqun. "Research on Enterprise's Dynamic Capabilities Action Mechanism." In 2011 International Conference on Information Management, Innovation Management and Industrial Engineering (ICIII). IEEE, 2011. http://dx.doi.org/10.1109/iciii.2011.415.

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Shih, Hsiao-Yi, and Arnost Reiser. "Mechanism of inhibitor action in novolak film." In SPIE's 1995 Symposium on Microlithography, edited by Robert D. Allen. SPIE, 1995. http://dx.doi.org/10.1117/12.210351.

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Reports on the topic "Mechanism of action of melatonin"

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Darrow, Janet M. Melatonin Action on the Circadian Pacemaker in Siberian Hamsters. Defense Technical Information Center, 1991. http://dx.doi.org/10.21236/ada243057.

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Roberts, Jr, and Charles T. A Novel Mechanism of Androgen Receptor Action. Defense Technical Information Center, 2008. http://dx.doi.org/10.21236/ada489364.

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Roberts, Jr, and Charles T. A Novel Mechanism of Androgen Receptor Action. Defense Technical Information Center, 2009. http://dx.doi.org/10.21236/ada503252.

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Bates, Paula J. Mechanism of Action of Novel Antiproliferative Oligonucleotides. Defense Technical Information Center, 2002. http://dx.doi.org/10.21236/ada406133.

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Roberts, Jr, and Charles T. A Novel Mechanism of Androgen Receptor Action. Defense Technical Information Center, 2007. http://dx.doi.org/10.21236/ada466168.

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Kamasani, Uma R., and George Prendergast. Mechanism of RhoB/FTI Action in Breast Cancer. Defense Technical Information Center, 2004. http://dx.doi.org/10.21236/ada446332.

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Rane, Neena S., and George C. Prendergast. Mechanism of RhoB/FTI Action in Breast Cancer. Defense Technical Information Center, 2002. http://dx.doi.org/10.21236/ada412302.

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Rogers, Terry B. Mechanism of Action of the Presynaptic Neurotoxin, Tetanus Toxin. Defense Technical Information Center, 1991. http://dx.doi.org/10.21236/ada246780.

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Rogers, Terry B. Mechanism of Action of the Presynaptic Neurotoxins Tetanus Toxin. Defense Technical Information Center, 1992. http://dx.doi.org/10.21236/ada246495.

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Kaiser, Ivan I. Rattlesnake Neurotoxin Structure, Mechanism of Action, Immunology and Molecular Biology. Defense Technical Information Center, 1990. http://dx.doi.org/10.21236/ada228003.

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